8W3X

IRAK4 (Interleukin-1 receptor-associated kinase 4)
Group: TKL
Uniprot: IRAK4_HUMAN
Organism: Homo sapiens
Domain boundary: 175 - 456
Resolu: 1.765

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAminus in-out in-in A1AFH Type1 162 - 460 5
B Inactive DFGin BLAminus in-out in-in A1AFH Type1 162 - 459 5
C Inactive DFGin BLAminus in-out in-in A1AFH Type1 164 - 459 4
D Inactive DFGin BLAminus in-out in-in A1AFH Type1 164 - 459 4
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain D
         -        157        167        177 
mhhhhhhgge nlyfqgenks levsdtRFHS FSFYELKNVT 
       187        197        207        217 
NNFDERPISV GGNKMGEGGF GVVYKGYVNN TTVAVKKLAa 
       227        237        247        257 
mvdiTTEELK QQFDQEIKVM AKCQHENLVE LLGFSSDGDD 
       267        277        287        297 
LCLVYVYMPN GSLLDRLSCL DGTPPLSWHM RCKIAQGAAN 
       307        317        327        337 
GINFLHENHH IHRDIKSANI LLDEAFTAKI SDFGLARASE 
       347        357        367        377 
kfaqTVMTSR IVGTTAYMAP EALRGEITPK SDIYSFGVVL 
       387        397        407        417 
LEIITGLPAV DEHREPQLLL DIKEEIEDEE KTIEDYIDKK 
       427        437        447        457 
MNDADSTSVE AMYSVASQCL HEKKNKRPDI KKVQQLLQEM 

TAs
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X342,X345,X346