6UYA

IRAK4 (Interleukin-1 receptor-associated kinase 4)
Group: TKL
Uniprot: IRAK4_HUMAN
Organism: Homo sapiens
Domain boundary: 175 - 456
Resolu: 1.74

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAminus in-out in-in QL7 Type1 163 - 458 5
B Inactive DFGin BLAminus in-out in-in QL7 Type1 165 - 458 4
C Active DFGin BLAminus in-in in-in QL7 Type1 162 - 458 6
D Inactive DFGin BLAminus in-out in-in QL7 Type1 162 - 458 6
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain D
         -        163        173        183 
mhhhhhhgen lyfqgsvsDT RFHSFSFYEL KNVTNNFDER 
       193        203        213        223 
PISVGGNKMG EGGFGVVYKG YVNNTTVAVK KLAAMVDITT 
       233        243        253        263 
EELKQQFDQE IKVMAKCQHE NLVELLGFSS DGDDLCLVYV 
       273        283        293        303 
YMPNGSLLDR LSCLDGTPPL SWHMRCKIAQ GAANGINFLH 
       313        323        333        343 
ENHHIHRDIK SANILLDEAF TAKISDFGLA RAsekfaqTV 
       353        363        373        383 
MTSRIVGTTA YMAPEALRGE ITPKSDIYSF GVVLLEIITG 
       393        403        413        423 
LPAVDEHREP QLLLDIKEEI EDEEKTIEDY IDKKMNDADS 
       433        443        453          - 
TSVEAMYSVA SQCLHEKKNK RPDIKKVQQL LQEMTasgns


Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X342,X345,X346