TYR_BTK (Tyrosine-protein kinase BTK)

Total number of chains: 147
Active chains: 2
Uniprot: BTK_HUMAN
Kinase Domain Residues: 402 - 653
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 133 90.5% 6DI1A
DFGin BLAplus 4 2.7% 1K2PA
DFGinter BABtrans 4 2.7% 7YC9A
DFGin BLAminus 2 1.4% AF-Q06187-K1A
DFGin None 2 1.4% 3PIYA
DFGinter None 1 0.7% 6NFIA
None None 1 0.7% 3PJ3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q06187-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 394 - 659 0 None None Tyrosine-protein kinase BTK
AF-Q06187-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 394 - 659 0 None None Tyrosine-protein kinase BTK
1K2PA 2.1 Inactive DFGin‑BLAplus out-out in-out TYR APEdihe_iiiai APEdist_aaao No_ligand No_ligand 397 - 654 0 None None Tyrosine-protein kinase BTK
3K54A 1.94 Inactive DFGin‑BLAplus in-out none-out TYR APEdihe_nniai APEdist_aaao 1N1 Type1 392 - 658 0 None Y551E Tyrosine-protein kinase BTK
3PIZA 2.21 Inactive DFGin‑BLAplus in-in none-out TYR APEdihe_nniai APEdist_aaao 03C Type1 391 - 659 0 None None Tyrosine-protein kinase BTK
3PJ1A 2.0 Inactive DFGin‑BLAplus in-in none-out TYR APEdihe_nniai APEdist_aaao LHL, LHL Type1, Allosteric 391 - 659 0 None None Tyrosine-protein kinase BTK
1K2PB 2.1 Inactive DFGin‑BLBplus out-out in-out TYR APEdihe_iioao APEdist_aaai No_ligand No_ligand 397 - 654 0 None None Tyrosine-protein kinase BTK
8YVVA 2.25 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_oiiai APEdist_aaao No_ligand No_ligand 394 - 658 0 None None Tyrosine-protein kinase BTK
8YVVB 2.25 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 395 - 658 0 None None Tyrosine-protein kinase BTK
3P08A 2.3 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao No_ligand No_ligand 394 - 658 0 None None Tyrosine-protein kinase BTK
3P08B 2.3 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 395 - 658 0 None None Tyrosine-protein kinase BTK
6W8IA 3.8 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_niiai APEdist_aaao No_ligand No_ligand 393 - 657 0 None None Tyrosine-protein kinase BTK
6W8IB 3.8 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 395 - 657 0 None None Tyrosine-protein kinase BTK
4NWMA 2.03 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 2P5 Type1 396 - 657 0 None None Tyrosine-protein kinase BTK
4NWMB 2.03 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 2P5 Type1 396 - 657 0 None None Tyrosine-protein kinase BTK
6AUBA 1.65 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao BXM Type1 395 - 657 0 None None Tyrosine-protein kinase BTK
6S90A 1.82 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao L0Z Type1 395 - 656 0 None None Tyrosine-protein kinase BTK
6S90B 1.82 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao L0Z Type1 395 - 656 0 None None Tyrosine-protein kinase BTK
5BPYA 2.31 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 4UQ Type1 396 - 657 0 None None Tyrosine-protein kinase BTK
5BPYB 2.31 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_nooai APEdist_aaao 4UQ Type1 396 - 657 0 None None Tyrosine-protein kinase BTK
5JRSA 1.97 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 6MV Type1 396 - 656 0 None None Tyrosine-protein kinase BTK
5JRSB 1.97 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_nooai APEdist_aaao 6MV Type1 396 - 655 0 None None Tyrosine-protein kinase BTK
5T18A 1.5 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 73T Type1 396 - 658 0 None None Tyrosine-protein kinase BTK
7KXNA 1.34 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao X9P Type1 394 - 659 0 None None Tyrosine-protein kinase BTK
7KXOA 1.94 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao X9S Type1 395 - 659 0 None None Tyrosine-protein kinase BTK
7LTYA 1.69 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao YD7 Type1 393 - 658 0 None None Tyrosine-protein kinase BTK
7LTZA 1.53 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao YDA Type1 394 - 658 0 None None Tyrosine-protein kinase BTK
7KXLA 1.84 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao X9J Type1 392 - 658 0 None None Tyrosine-protein kinase BTK
5ZZ4A 2.9 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 9M3 Type1 395 - 655 0 None None Tyrosine-protein kinase BTK
5ZZ4B 2.9 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 9M3 Type1 393 - 655 0 None None Tyrosine-protein kinase BTK
5ZZ4C 2.9 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 9M3 Type1 394 - 655 0 None None Tyrosine-protein kinase BTK
5ZZ4D 2.9 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 9M3 Type1 393 - 655 0 None None Tyrosine-protein kinase BTK
5ZZ4E 2.9 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 9M3 Type1 394 - 655 0 None None Tyrosine-protein kinase BTK
5ZZ4F 2.9 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 9M3 Type1 393 - 655 0 None None Tyrosine-protein kinase BTK
6O8IA 1.42 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_iiiai APEdist_aaao LTJ Type1 391 - 658 0 None None Tyrosine-protein kinase BTK
7N4QA 1.5 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 0B9 Type1 392 - 658 0 None None Tyrosine-protein kinase BTK
7N4RA 1.62 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao 0BG Type1 393 - 658 0 None None Tyrosine-protein kinase BTK
7N4SA 2.05 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 0B0 Type1 394 - 658 0 None None Tyrosine-protein kinase BTK
4RX5A 1.356 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 3YO Type1 394 - 657 0 None None Tyrosine-protein kinase BTK
5KUPA 1.389 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 6XL Type1 394 - 657 0 None None Tyrosine-protein kinase BTK
5VGOA 1.621 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 9B1 Type1 394 - 657 0 None None Tyrosine-protein kinase BTK
7KXQA 1.38 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao X9Y Type1 390 - 659 0 None None Tyrosine-protein kinase BTK
3OCSA 1.8 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 746 Type1 395 - 656 0 None None Tyrosine-protein kinase BTK
4OTFA 1.95 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 2VL Type1 396 - 657 0 None None Tyrosine-protein kinase BTK
4ZLYA 1.65 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 4RU Type1 389 - 658 0 None None Tyrosine-protein kinase BTK
4ZLZA 2.0 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 4RV Type1 389 - 658 0 None None Tyrosine-protein kinase BTK
8GC7A 1.9 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao YXJ Type1 389 - 658 0 None None Tyrosine-protein kinase BTK
8U2DA 1.95 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao UQX Type1 389 - 658 0 None None Tyrosine-protein kinase BTK
8U2EA 1.9 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao UP9 Type1 389 - 658 0 None None Tyrosine-protein kinase BTK
5U9DA 1.33 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 83P Type1 389 - 659 0 None None Tyrosine-protein kinase BTK
5VFIA 1.59 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 9AJ Type1 389 - 659 0 None None Tyrosine-protein kinase BTK
6DI0A 1.3 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao GJG Type1 389 - 659 0 None None Tyrosine-protein kinase BTK
6DI1A 1.1 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao GJD Type1 389 - 659 0 None None Tyrosine-protein kinase BTK
6DI9A 1.25 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_niiai APEdist_aaao GJJ Type1 392 - 659 0 None None Tyrosine-protein kinase BTK
6NFHA 1.4 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao KLM Type1 389 - 659 0 None None Tyrosine-protein kinase BTK
7KXMA 1.33 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao X9M Type1 389 - 659 0 None None Tyrosine-protein kinase BTK
7KXPA 1.83 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao X9V Type1 389 - 659 0 None None Tyrosine-protein kinase BTK
3PIXA 1.85 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_iiiai APEdist_aaao 027 Type1 391 - 658 0 None None Tyrosine-protein kinase BTK
5J87A 1.59 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao N42 Type1 396 - 658 0 None None Tyrosine-protein kinase BTK
5J87B 1.59 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao N42 Type1 385 - 658 0 None None Tyrosine-protein kinase BTK
5J87C 1.59 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao N42 Type1 396 - 656 0 None None Tyrosine-protein kinase BTK
5J87D 1.59 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao N42 Type1 396 - 658 0 None None Tyrosine-protein kinase BTK
6TFPA 2.0 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao N6Z Type1 393 - 658 0 None None Tyrosine-protein kinase BTK
6TFPB 2.0 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao N6Z Type1 385 - 658 0 None None Tyrosine-protein kinase BTK
6TFPC 2.0 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao N6Z Type1 394 - 657 0 None None Tyrosine-protein kinase BTK
6TFPD 2.0 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao N6Z Type1 392 - 657 0 None None Tyrosine-protein kinase BTK
6TFPE 2.0 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao N6Z Type1 394 - 657 0 None None Tyrosine-protein kinase BTK
5P9FA 1.71 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 2VL Type1 394 - 659 0 None None Tyrosine-protein kinase BTK
5P9GA 1.75 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 7G6 Type1 394 - 658 0 None None Tyrosine-protein kinase BTK
5P9HA 1.95 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 7G7 Type1 395 - 658 0 None None Tyrosine-protein kinase BTK
5P9KA 1.28 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 7G8 Type1 389 - 659 0 None None Tyrosine-protein kinase BTK
5P9LA 1.25 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_niiai APEdist_aaao 7G9 Type1 392 - 657 0 None None Tyrosine-protein kinase BTK
6AUAA 1.66 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao BXJ Type1 394 - 656 0 None None Tyrosine-protein kinase BTK
6NZMA 1.72 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao L9S Type1 395 - 659 0 None None Tyrosine-protein kinase BTK
6NZMD 1.72 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao L9S Type1 395 - 659 0 None None Tyrosine-protein kinase BTK
5BQ0A 1.57 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao 4US Type1 389 - 659 0 None None Tyrosine-protein kinase BTK
8FLHA 1.55 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao Y8H Type1 392 - 658 0 None None Tyrosine-protein kinase BTK
8FLVA 1.3 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao ZB9 Type1 393 - 659 0 None None Tyrosine-protein kinase BTK
8TU3A 1.7 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao UEO Type1 394 - 659 0 None None Tyrosine-protein kinase BTK
8TU4A 1.6 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao V72 Type1 394 - 659 0 None None Tyrosine-protein kinase BTK
8TU5A 2.1 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_nniai APEdist_aaao V7I Type1 395 - 657 0 None None Tyrosine-protein kinase BTK
4Z3VA 1.6 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 4L6 Type1 389 - 659 0 None None Tyrosine-protein kinase BTK
7N5OA 1.25 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 0BQ Type1 389 - 658 0 None None Tyrosine-protein kinase BTK
7N5RA 1.55 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 0UW Type1 389 - 658 0 None None Tyrosine-protein kinase BTK
7N5XA 1.6 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 0GW Type1 389 - 658 0 None None Tyrosine-protein kinase BTK
7N5YA 1.85 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 0CI Type1 389 - 658 0 None None Tyrosine-protein kinase BTK
6BIKA 1.901 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao DTJ Type1 395 - 657 0 None None Tyrosine-protein kinase BTK
6BKEA 1.95 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao DVJ Type1 395 - 657 0 None None Tyrosine-protein kinase BTK
6BKHA 1.792 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao DVD Type1 396 - 657 0 None None Tyrosine-protein kinase BTK
6BLNA 1.3 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao DY4 Type1 395 - 657 0 None None Tyrosine-protein kinase BTK
6XE4A 1.6 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao V1G Type1 395 - 657 0 None None Tyrosine-protein kinase BTK
6VXQA 1.4 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao RQS Type1 392 - 658 0 None None Tyrosine-protein kinase BTK
6W06A 1.55 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao S5M Type1 393 - 659 0 None None Tyrosine-protein kinase BTK
6W07A 1.51 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao S9A Type1 393 - 658 0 None None Tyrosine-protein kinase BTK
8FLGA 2.2 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao Y8C Type1 395 - 659 0 None None Tyrosine-protein kinase BTK
4OT5A 1.55 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 481 Type1 396 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK
4OT6A 2.05 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 2V1 Type1 394 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK
4OTQA 1.55 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 2V2 Type1 396 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK
4OTRA 1.95 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 2V3 Type1 396 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK
4RFYA 1.7 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 3OU Type1 396 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK
4RFZA 1.17 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 3OV Type1 396 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK
4RG0A 2.5 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 3P0 Type1 396 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK
6EP9A 2.01 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao BNB Type1 396 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK
6HRPA 1.12 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao GMQ Type1 396 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK
6HRTA 1.36 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao GMW Type1 396 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK
8GC8A 1.75 Inactive DFGin‑BLBplus out-none none-out TYR APEdihe_niiai APEdist_aaao YXJ Type1 392 - 658 0 None L528W Tyrosine-protein kinase BTK
8EJBA 1.58 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao WKC, PD Type1, Allosteric 389 - 658 0 None None Tyrosine-protein kinase BTK
6X3NA 1.95 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_niiai APEdist_aaai ULV, 5WE Type1, Allosteric 392 - 659 0 None None Tyrosine-protein kinase BTK
6BKWA 1.499 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao DXM, FPZ Type1, Type1 393 - 657 0 None None Tyrosine-protein kinase BTK
6J6MA 1.25 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao BA0 Type1.5_Back 393 - 659 0 None None Tyrosine-protein kinase BTK
7R61A 1.52 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 2IJ Type1.5_Back 390 - 659 0 None None Tyrosine-protein kinase BTK
6DI3A 2.0 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao GJA Type1.5_Back 393 - 659 0 None None Tyrosine-protein kinase BTK
6DI5A 1.42 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao GJ7 Type1.5_Back 389 - 659 0 None None Tyrosine-protein kinase BTK
6N9PA 2.23 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao KHD Type1.5_Back 389 - 659 0 None None Tyrosine-protein kinase BTK
6OMUA 1.41 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao MZJ Type1.5_Back 389 - 659 0 None None Tyrosine-protein kinase BTK
7L5OA 1.21 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao R1L Type1.5_Back 389 - 658 0 None None Tyrosine-protein kinase BTK
7L5PA 2.14 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao R1L Type1.5_Back 392 - 659 0 None None Tyrosine-protein kinase BTK
7L5PB 2.14 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao R1L Type1.5_Back 393 - 658 0 None None Tyrosine-protein kinase BTK
7R60A 1.94 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 2IE Type1.5_Back 389 - 659 0 None None Tyrosine-protein kinase BTK
8E2MA 1.904 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao UB6 Type1.5_Back 389 - 658 0 None None Tyrosine-protein kinase BTK
6W7OA 2.17 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao TL7 Type1.5_Back 396 - 656 0 None None Tyrosine-protein kinase BTK
6W7OB 2.17 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao TL7 Type1.5_Back 396 - 658 0 None None Tyrosine-protein kinase BTK
6W8IC 3.8 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao TKY Type1.5_Back 395 - 657 0 None None Tyrosine-protein kinase BTK
8DSOB 2.334 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_iooai APEdist_aaao TOO Type1.5_Back 392 - 659 0 None None Tyrosine-protein kinase BTK
4YHFA 2.2 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 4C9 Type1.5_Back 391 - 658 0 None None Tyrosine-protein kinase BTK
4YHFB 2.2 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 4C9 Type1.5_Back 390 - 658 0 None None Tyrosine-protein kinase BTK
5P9IA 1.11 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 1E8 Type1.5_Back 389 - 659 0 None None Tyrosine-protein kinase BTK
5P9JA 1.08 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 8E8 Type1.5_Back 394 - 659 0 None None Tyrosine-protein kinase BTK
5P9MA 1.41 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 7GB Type1.5_Back 389 - 659 0 None None Tyrosine-protein kinase BTK
3GENA 1.6 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao B43 Type1.5_Back 392 - 658 0 None None Tyrosine-protein kinase BTK
6E4FA 1.15 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao HRA Type1.5_Back 389 - 658 0 None None Tyrosine-protein kinase BTK
5FBOA 1.894 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_oiiai APEdist_aaao 5WH, 5WE Type1.5_Back, Allosteric 392 - 659 0 None None Tyrosine-protein kinase BTK
8FLNA 1.334 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao Y7W, BTB Type1.5_Front, Allosteric 395 - 657 0 None None Tyrosine-protein kinase BTK
5FBNC 1.8 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 5WF, 5WE Type1.5_Front, Allosteric 395 - 658 0 None None Tyrosine-protein kinase BTK
6X3OA 1.9 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao ULY, 5WE Type1.5_Front, Allosteric 395 - 659 0 None None Tyrosine-protein kinase BTK
6X3OB 1.9 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao ULY, 5WE Type1.5_Front, Allosteric 393 - 659 0 None None Tyrosine-protein kinase BTK
8FLLA 1.498 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao Y7W, BTB Type1.5_Front, Allosteric 395 - 658 0 None None Tyrosine-protein kinase BTK
5FBND 1.8 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai 5WF, 5WE, 5WE, 5WE Type1.5_Front, Allosteric, Allosteric, Allosteric 394 - 658 0 None None Tyrosine-protein kinase BTK
6X3PA 1.34 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao UM4, UM4, BTB Type1.5_Front, Allosteric, Type1 394 - 659 0 None None Tyrosine-protein kinase BTK
3PIYA 2.55 Inactive DFGin‑None out-out out-out TYR APEdihe_oiiai APEdist_aaao 585 Type1 391 - 658 0 None None Tyrosine-protein kinase BTK
3PJ2A 1.75 Inactive DFGin‑None out-out none-out TYR APEdihe_nniai APEdist_aaao 04K Type1.5_Back 391 - 659 0 None None Tyrosine-protein kinase BTK
5XYZA 2.64 Inactive DFGinter‑BABtrans out-out out-none TYR APEdihe_nniai APEdist_aaai GYL Type1 394 - 656 0 None None Tyrosine-protein kinase BTK
5XYZB 2.64 Inactive DFGinter‑BABtrans out-out out-none TYR APEdihe_nniai APEdist_aaai GYL Type1 394 - 656 0 None None Tyrosine-protein kinase BTK
7YC9A 1.4 Inactive DFGinter‑BABtrans out-out out-in TYR APEdihe_iiiai APEdist_aaai IS4 Type1 395 - 658 0 None None Tyrosine-protein kinase BTK
3OCTA 1.95 Inactive DFGinter‑BABtrans in-out out-none TYR APEdihe_nniai APEdist_aaai 1N1 Type1 394 - 656 0 None V555R Tyrosine-protein kinase BTK
6NFIA 2.41 Inactive DFGinter‑None out-out none-out TYR APEdihe_niiai APEdist_aaao KLP Type1 392 - 659 0 None None Tyrosine-protein kinase BTK
3PJ3A 1.85 Inactive None‑None in-in none-out TYR APEdihe_nniai APEdist_aaao 04L Type1 391 - 659 0 None None Tyrosine-protein kinase BTK

TYR_BTK (Tyrosine-protein kinase BTK)

Total number of chains: 171
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 155 90.6% 6DI1A
DFGinter BABtrans 6 3.5% 7YC9A
DFGin BLAplus 4 2.3% 1K2PA
DFGin BLAminus 2 1.2% AF-Q06187-K1A
DFGin None 2 1.2% 3PIYA
DFGinter None 1 0.6% 6NFIA
None None 1 0.6% 3PJ3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
Q3ZC95_BOVIN 4Y95A 1.599 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 746 Type1 395 - 659 0 None L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase Bos taurus
Q3ZC95_BOVIN 4Y95D 1.599 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 746 Type1 395 - 659 0 None L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase Bos taurus
Q3ZC95_BOVIN 4Y93A 1.695 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 746 Type1 1 - 658 0 None L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase Bos taurus
Q3ZC95_BOVIN 4Y95B 1.599 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 746, PE4 Type1, Allosteric 395 - 659 0 None L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase Bos taurus
Q3ZC95_BOVIN 4Y95C 1.599 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 746, PE4 Type1, Allosteric 395 - 659 0 None L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase Bos taurus
BTK_HUMAN AF-Q06187-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 394 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN AF-Q06187-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 394 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 1K2PA 2.1 Inactive DFGin‑BLAplus out-out in-out TYR APEdihe_iiiai APEdist_aaao No_ligand No_ligand 397 - 654 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 3K54A 1.94 Inactive DFGin‑BLAplus in-out none-out TYR APEdihe_nniai APEdist_aaao 1N1 Type1 392 - 658 0 None Y551E Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 3PIZA 2.21 Inactive DFGin‑BLAplus in-in none-out TYR APEdihe_nniai APEdist_aaao 03C Type1 391 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 3PJ1A 2.0 Inactive DFGin‑BLAplus in-in none-out TYR APEdihe_nniai APEdist_aaao LHL, LHL Type1, Allosteric 391 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 1K2PB 2.1 Inactive DFGin‑BLBplus out-out in-out TYR APEdihe_iioao APEdist_aaai No_ligand No_ligand 397 - 654 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 8YVVA 2.25 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_oiiai APEdist_aaao No_ligand No_ligand 394 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 8YVVB 2.25 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 395 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 3P08A 2.3 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao No_ligand No_ligand 394 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 3P08B 2.3 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 395 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6W8IA 3.8 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_niiai APEdist_aaao No_ligand No_ligand 393 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6W8IB 3.8 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 395 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 4NWMA 2.03 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 2P5 Type1 396 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 4NWMB 2.03 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 2P5 Type1 396 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6AUBA 1.65 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao BXM Type1 395 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6S90A 1.82 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao L0Z Type1 395 - 656 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6S90B 1.82 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao L0Z Type1 395 - 656 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5BPYA 2.31 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 4UQ Type1 396 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5BPYB 2.31 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_nooai APEdist_aaao 4UQ Type1 396 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5JRSA 1.97 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 6MV Type1 396 - 656 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5JRSB 1.97 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_nooai APEdist_aaao 6MV Type1 396 - 655 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5T18A 1.5 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 73T Type1 396 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7KXNA 1.34 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao X9P Type1 394 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7KXOA 1.94 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao X9S Type1 395 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7LTYA 1.69 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao YD7 Type1 393 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7LTZA 1.53 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao YDA Type1 394 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7KXLA 1.84 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao X9J Type1 392 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5ZZ4A 2.9 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 9M3 Type1 395 - 655 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5ZZ4B 2.9 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 9M3 Type1 393 - 655 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5ZZ4C 2.9 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 9M3 Type1 394 - 655 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5ZZ4D 2.9 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 9M3 Type1 393 - 655 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5ZZ4E 2.9 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 9M3 Type1 394 - 655 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5ZZ4F 2.9 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 9M3 Type1 393 - 655 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6O8IA 1.42 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_iiiai APEdist_aaao LTJ Type1 391 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7N4QA 1.5 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 0B9 Type1 392 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7N4RA 1.62 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao 0BG Type1 393 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7N4SA 2.05 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 0B0 Type1 394 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 4RX5A 1.356 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 3YO Type1 394 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5KUPA 1.389 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 6XL Type1 394 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5VGOA 1.621 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 9B1 Type1 394 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7KXQA 1.38 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao X9Y Type1 390 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 3OCSA 1.8 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 746 Type1 395 - 656 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 4OTFA 1.95 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 2VL Type1 396 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 4ZLYA 1.65 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 4RU Type1 389 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 4ZLZA 2.0 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 4RV Type1 389 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 8GC7A 1.9 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao YXJ Type1 389 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 8U2DA 1.95 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao UQX Type1 389 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 8U2EA 1.9 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao UP9 Type1 389 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5U9DA 1.33 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 83P Type1 389 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5VFIA 1.59 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 9AJ Type1 389 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6DI0A 1.3 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao GJG Type1 389 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6DI1A 1.1 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao GJD Type1 389 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6DI9A 1.25 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_niiai APEdist_aaao GJJ Type1 392 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6NFHA 1.4 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao KLM Type1 389 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7KXMA 1.33 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao X9M Type1 389 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7KXPA 1.83 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao X9V Type1 389 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 3PIXA 1.85 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_iiiai APEdist_aaao 027 Type1 391 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5J87A 1.59 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao N42 Type1 396 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5J87B 1.59 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao N42 Type1 385 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5J87C 1.59 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao N42 Type1 396 - 656 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5J87D 1.59 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao N42 Type1 396 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6TFPA 2.0 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao N6Z Type1 393 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6TFPB 2.0 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao N6Z Type1 385 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6TFPC 2.0 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao N6Z Type1 394 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6TFPD 2.0 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao N6Z Type1 392 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6TFPE 2.0 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao N6Z Type1 394 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5P9FA 1.71 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 2VL Type1 394 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5P9GA 1.75 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 7G6 Type1 394 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5P9HA 1.95 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 7G7 Type1 395 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5P9KA 1.28 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 7G8 Type1 389 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5P9LA 1.25 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_niiai APEdist_aaao 7G9 Type1 392 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6AUAA 1.66 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao BXJ Type1 394 - 656 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6NZMA 1.72 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao L9S Type1 395 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6NZMD 1.72 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao L9S Type1 395 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5BQ0A 1.57 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao 4US Type1 389 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 8FLHA 1.55 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao Y8H Type1 392 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 8FLVA 1.3 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao ZB9 Type1 393 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 8TU3A 1.7 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao UEO Type1 394 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 8TU4A 1.6 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao V72 Type1 394 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 8TU5A 2.1 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_nniai APEdist_aaao V7I Type1 395 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 4Z3VA 1.6 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 4L6 Type1 389 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7N5OA 1.25 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 0BQ Type1 389 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7N5RA 1.55 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 0UW Type1 389 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7N5XA 1.6 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 0GW Type1 389 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7N5YA 1.85 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 0CI Type1 389 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6BIKA 1.901 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao DTJ Type1 395 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6BKEA 1.95 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao DVJ Type1 395 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6BKHA 1.792 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao DVD Type1 396 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6BLNA 1.3 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao DY4 Type1 395 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6XE4A 1.6 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao V1G Type1 395 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6VXQA 1.4 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao RQS Type1 392 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6W06A 1.55 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao S5M Type1 393 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6W07A 1.51 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao S9A Type1 393 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 8FLGA 2.2 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao Y8C Type1 395 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 4OT5A 1.55 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 481 Type1 396 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 4OT6A 2.05 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 2V1 Type1 394 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 4OTQA 1.55 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 2V2 Type1 396 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 4OTRA 1.95 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 2V3 Type1 396 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 4RFYA 1.7 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 3OU Type1 396 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 4RFZA 1.17 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 3OV Type1 396 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 4RG0A 2.5 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 3P0 Type1 396 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6EP9A 2.01 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao BNB Type1 396 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6HRPA 1.12 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao GMQ Type1 396 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6HRTA 1.36 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao GMW Type1 396 - 658 0 None M489A,R492A,E624A,K625A Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 8GC8A 1.75 Inactive DFGin‑BLBplus out-none none-out TYR APEdihe_niiai APEdist_aaao YXJ Type1 392 - 658 0 None L528W Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 8EJBA 1.58 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao WKC, PD Type1, Allosteric 389 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6X3NA 1.95 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_niiai APEdist_aaai ULV, 5WE Type1, Allosteric 392 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6BKWA 1.499 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao DXM, FPZ Type1, Type1 393 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6J6MA 1.25 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao BA0 Type1.5_Back 393 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7R61A 1.52 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 2IJ Type1.5_Back 390 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6DI3A 2.0 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao GJA Type1.5_Back 393 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6DI5A 1.42 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao GJ7 Type1.5_Back 389 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6N9PA 2.23 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao KHD Type1.5_Back 389 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6OMUA 1.41 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao MZJ Type1.5_Back 389 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7L5OA 1.21 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao R1L Type1.5_Back 389 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7L5PA 2.14 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao R1L Type1.5_Back 392 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7L5PB 2.14 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao R1L Type1.5_Back 393 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7R60A 1.94 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 2IE Type1.5_Back 389 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 8E2MA 1.904 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao UB6 Type1.5_Back 389 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6W7OA 2.17 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao TL7 Type1.5_Back 396 - 656 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6W7OB 2.17 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao TL7 Type1.5_Back 396 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6W8IC 3.8 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao TKY Type1.5_Back 395 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 8DSOB 2.334 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_iooai APEdist_aaao TOO Type1.5_Back 392 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 4YHFA 2.2 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 4C9 Type1.5_Back 391 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 4YHFB 2.2 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 4C9 Type1.5_Back 390 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5P9IA 1.11 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 1E8 Type1.5_Back 389 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5P9JA 1.08 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 8E8 Type1.5_Back 394 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5P9MA 1.41 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 7GB Type1.5_Back 389 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 3GENA 1.6 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao B43 Type1.5_Back 392 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6E4FA 1.15 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao HRA Type1.5_Back 389 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5FBOA 1.894 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_oiiai APEdist_aaao 5WH, 5WE Type1.5_Back, Allosteric 392 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 8FLNA 1.334 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao Y7W, BTB Type1.5_Front, Allosteric 395 - 657 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5FBNC 1.8 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 5WF, 5WE Type1.5_Front, Allosteric 395 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6X3OA 1.9 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao ULY, 5WE Type1.5_Front, Allosteric 395 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6X3OB 1.9 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao ULY, 5WE Type1.5_Front, Allosteric 393 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 8FLLA 1.498 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao Y7W, BTB Type1.5_Front, Allosteric 395 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5FBND 1.8 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai 5WF, 5WE, 5WE, 5WE Type1.5_Front, Allosteric, Allosteric, Allosteric 394 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6X3PA 1.34 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao UM4, UM4, BTB Type1.5_Front, Allosteric, Type1 394 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 3PIYA 2.55 Inactive DFGin‑None out-out out-out TYR APEdihe_oiiai APEdist_aaao 585 Type1 391 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 3PJ2A 1.75 Inactive DFGin‑None out-out none-out TYR APEdihe_nniai APEdist_aaao 04K Type1.5_Back 391 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5XYZA 2.64 Inactive DFGinter‑BABtrans out-out out-none TYR APEdihe_nniai APEdist_aaai GYL Type1 394 - 656 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 5XYZB 2.64 Inactive DFGinter‑BABtrans out-out out-none TYR APEdihe_nniai APEdist_aaai GYL Type1 394 - 656 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 7YC9A 1.4 Inactive DFGinter‑BABtrans out-out out-in TYR APEdihe_iiiai APEdist_aaai IS4 Type1 395 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 3OCTA 1.95 Inactive DFGinter‑BABtrans in-out out-none TYR APEdihe_nniai APEdist_aaai 1N1 Type1 394 - 656 0 None V555R Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 6NFIA 2.41 Inactive DFGinter‑None out-out none-out TYR APEdihe_niiai APEdist_aaao KLP Type1 392 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_HUMAN 3PJ3A 1.85 Inactive None‑None in-in none-out TYR APEdihe_nniai APEdist_aaao 04L Type1 391 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
BTK_MOUSE 6MNYB 2.8 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 395 - 656 0 None None Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 4XI2A 2.6 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao No_ligand No_ligand 214 - 657 0 None None Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 8S93A 2.1 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 9AJ Type1 1 - 659 0 None Q91A,I92A,I94A,I95A,K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 8GMBA 3.4 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 9AJ Type1 214 - 659 0 None E298A,K300A,E301A,A384P,S386P,T387P,A388P,L390F,K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 6MNYA 2.8 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao JVP Type1.5_Back 395 - 656 0 None None Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 8FD9A 1.7 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao XQQ Type1.5_Back 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 8FF0A 2.6 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 7GB Type1.5_Back 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9EJXA 2.86 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao A1BI1 Type1.5_Back 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9ME2A 3.38 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao A1BKW Type1.5_Back 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9ME3A 3.05 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao A1BJE Type1.5_Back 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9EJJA 2.03 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oooai APEdist_aaao A1BIZ Type1.5_Front 394 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9EJJB 2.03 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_iooai APEdist_aaao A1BIZ Type1.5_Front 394 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9EJRA 2.1 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_iooai APEdist_aaao A1BI0 Type1.5_Front 394 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9EJRB 2.1 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_iooai APEdist_aaao A1BI0 Type1.5_Front 394 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9EJSA 2.26 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao A1BI0 Type1.5_Front 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9EJSB 2.26 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao A1BI0 Type1.5_Front 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9EJSC 2.26 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao A1BI0 Type1.5_Front 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 8S9FA 2.6 Inactive DFGinter‑BABtrans out-out out-none TYR APEdihe_nnnai APEdist_aaan 1N1 Type1 392 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 8S9FB 2.6 Inactive DFGinter‑BABtrans out-out out-out TYR APEdihe_niiai APEdist_aaao 1N1 Type1 392 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus

TYR_BTK (Tyrosine-protein kinase BTK)

Total number of chains: 24
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 22 91.7% 4Y95A
DFGinter BABtrans 2 8.3% 8S9FB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
Q3ZC95_BOVIN 4Y95A 1.599 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 746 Type1 395 - 659 0 None L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase Bos taurus
Q3ZC95_BOVIN 4Y95D 1.599 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 746 Type1 395 - 659 0 None L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase Bos taurus
Q3ZC95_BOVIN 4Y93A 1.695 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 746 Type1 1 - 658 0 None L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase Bos taurus
Q3ZC95_BOVIN 4Y95B 1.599 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 746, PE4 Type1, Allosteric 395 - 659 0 None L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase Bos taurus
Q3ZC95_BOVIN 4Y95C 1.599 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 746, PE4 Type1, Allosteric 395 - 659 0 None L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase Bos taurus
BTK_MOUSE 6MNYB 2.8 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 395 - 656 0 None None Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 4XI2A 2.6 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao No_ligand No_ligand 214 - 657 0 None None Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 8S93A 2.1 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 9AJ Type1 1 - 659 0 None Q91A,I92A,I94A,I95A,K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 8GMBA 3.4 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 9AJ Type1 214 - 659 0 None E298A,K300A,E301A,A384P,S386P,T387P,A388P,L390F,K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 6MNYA 2.8 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao JVP Type1.5_Back 395 - 656 0 None None Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 8FD9A 1.7 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao XQQ Type1.5_Back 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 8FF0A 2.6 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao 7GB Type1.5_Back 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9EJXA 2.86 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao A1BI1 Type1.5_Back 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9ME2A 3.38 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao A1BKW Type1.5_Back 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9ME3A 3.05 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao A1BJE Type1.5_Back 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9EJJA 2.03 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oooai APEdist_aaao A1BIZ Type1.5_Front 394 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9EJJB 2.03 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_iooai APEdist_aaao A1BIZ Type1.5_Front 394 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9EJRA 2.1 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_iooai APEdist_aaao A1BI0 Type1.5_Front 394 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9EJRB 2.1 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_iooai APEdist_aaao A1BI0 Type1.5_Front 394 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9EJSA 2.26 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao A1BI0 Type1.5_Front 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9EJSB 2.26 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao A1BI0 Type1.5_Front 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 9EJSC 2.26 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao A1BI0 Type1.5_Front 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 8S9FA 2.6 Inactive DFGinter‑BABtrans out-out out-none TYR APEdihe_nnnai APEdist_aaan 1N1 Type1 392 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
BTK_MOUSE 8S9FB 2.6 Inactive DFGinter‑BABtrans out-out out-out TYR APEdihe_niiai APEdist_aaao 1N1 Type1 392 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus