Ligand: LHL

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 3KMMA
DFGin BLAplus 1 50.0% 3PJ1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR BTK BTK_HUMAN 3PJ1A 2.0 Inactive DFGin‑BLAplus in-in none-out TYR APEdihe_nniai APEdist_aaao LHL, LHL Type1, Allosteric 391 - 659 0 None None Tyrosine-protein kinase BTK
TYR LCK LCK_HUMAN 3KMMA 2.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai LHL Type1.5_Back 231 - 501 0 PTR394 Y505F Tyrosine-protein kinase Lck

Ligand: LHL

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 3KMMA
DFGin BLAplus 1 50.0% 3PJ1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR BTK BTK_HUMAN 3PJ1A 2.0 Inactive DFGin‑BLAplus in-in none-out TYR APEdihe_nniai APEdist_aaao LHL, LHL Type1, Allosteric 391 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
TYR LCK LCK_HUMAN 3KMMA 2.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai LHL Type1.5_Back 231 - 501 0 PTR394 Y505F Tyrosine-protein kinase Lck Homo sapiens

Ligand: LHL

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism