TYR_BTK (Tyrosine-protein kinase BTK)

Total number of chains: 147
Active chains: 2
Uniprot: BTK_HUMAN
Kinase Domain Residues: 402 - 653
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 133 90.5% 6DI1A
DFGin BLAplus 4 2.7% 1K2PA
DFGinter BABtrans 4 2.7% 7YC9A
DFGin BLAminus 2 1.4% AF-Q06187-K1A
DFGin None 2 1.4% 3PIYA
DFGinter None 1 0.7% 6NFIA
None None 1 0.7% 3PJ3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
BTK AF-Q06187-K1A Q06187 394 659 659.0 No_ligand No_ligand Active DFGin 6.6004 13.573 BLAminus -136.86, -178.35 58.88, 65.72 -79.63, 17.44 303.15, 95.81 -59.47, -35.89 in-in in 8.3739 Saltbr-in 2.6582 HRD-in -82.15, -43.22 66.84, -17.66 in-in-in SNCiii in-in ActLoopNT-in 2.8953 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.5, 145.43 APE9-dihe-in -141.06, 156.51 APE8-dihe-in -76.86, 86.05 APE8-rot-na 33.19 APE67-dihe-in -71.15, -13.64 -39.83, -42.64 APE12-dist-na 14.9168 APE11-dist-na 10.113 APE10-dist-na 11.7731 APE9-dist-in 6.7406 None None None AF2 -1.0 1.0 1.0 A 266.0 266.0 0 29 29 0 [[402, 653]] 1.0 AF-Q06187-K1 TYR_BTK_HUMAN TYR 5.6e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK AF-Q06187-K3A Q06187 394 659 659.0 No_ligand No_ligand Active DFGin 6.1019 13.8994 BLAminus -145.41, -175.94 66.17, 62.18 -83.37, 7.8 301.85, 98.96 -63.25, -28.92 in-in in 8.3689 Saltbr-in 2.681 HRD-in -81.43, -44.92 68.23, -10.51 in-in-in SNCiii in-in ActLoopNT-in 2.8809 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.17, 138.32 APE9-dihe-in -148.99, 160.92 APE8-dihe-in -83.4, 78.18 APE8-rot-na 37.74 APE67-dihe-in -68.88, -18.16 -34.0, -49.11 APE12-dist-na 14.4676 APE11-dist-na 9.7184 APE10-dist-na 9.98 APE9-dist-in 5.5801 None None None AF2 -1.0 1.0 1.0 A 266.0 266.0 0 29 29 0 [[402, 653]] 1.0 AF-Q06187-K3 TYR_BTK_HUMAN TYR 5.6e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 1K2PA Q06187 397 654 659.0 No_ligand No_ligand Inactive DFGin 6.2691 13.6092 BLAplus -137.21, -161.69 45.76, 46.11 -111.57, 23.49 52.19, 85.05 -57.85, -62.14 out-out out 13.2869 Saltbr-out 10.6239 HRD-out -102.12, 102.51 -76.81, 5.84 out-in-out SNCoio in-out ActLoopNT-in 3.3416 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -178.37, 168.38 APE9-dihe-in -137.01, 135.64 APE8-dihe-in -77.95, 68.38 APE8-rot-na 27.72 APE67-dihe-in -66.74, -7.07 -47.38, -37.03 APE12-dist-na 14.5076 APE11-dist-na 13.5124 APE10-dist-na 15.7561 APE9-dist-out 8.121 None None None XRAY 2.1 0.28 0.287 A 263.0 258.0 0 29 29 0 [[402, 653]] 1.0 1k2p TYR_BTK_HUMAN TYR 5.4e-93 317.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 3K54A Q06187 392 658 659.0 1N1:1 Type1 Inactive DFGin 4.6816 13.9981 BLAplus -132.68, -179.17 50.27, 30.98 -93.41, -0.42 58.12, 86.77 -82.65, 999.0 in-out in 8.7866 Saltbr-out 3.7709 HRD-in -69.54, -47.61 72.38, -12.01 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.06 APE8-dihe-in -84.11, 69.82 APE8-rot-na 29.89 APE67-dihe-in -70.22, -9.36 -47.67, -47.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1055 Y551E None None XRAY 1.94 0.202 0.258 A 283.0 243.0 24 29 12 17 [[402, 653]] 1.0 3k54 TYR_BTK_HUMAN TYR 1.6e-92 315.4 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 3PIZA Q06187 391 659 659.0 03C:1 Type1 Inactive DFGin 4.8889 14.1264 BLAplus -126.33, -179.6 57.13, 22.66 -85.31, -11.74 58.57, 94.3 -83.53, -14.98 in-in in 7.9755 Saltbr-in 2.76 HRD-in -82.17, -49.28 74.06, -8.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.57 APE8-dihe-in -71.57, 69.01 APE8-rot-na 28.32 APE67-dihe-in -70.88, -14.79 -58.9, -38.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2112 None None None XRAY 2.21 0.228 0.282 A 274.0 245.0 24 29 13 16 [[402, 653]] 1.0 3piz TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 3PJ1A Q06187 391 659 659.0 LHL:1,LHL:2 Type1,Allosteric Inactive DFGin 4.6315 13.9108 BLAplus -125.24, -177.97 47.53, 37.44 -91.22, -16.21 57.77, 94.29 -84.9, -7.73 in-in in 8.2391 Saltbr-in 3.0498 HRD-in -71.17, -51.36 76.56, -15.56 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.95 APE8-dihe-in -68.38, 60.28 APE8-rot-na 27.48 APE67-dihe-in -69.28, -12.51 -52.55, -45.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1998 None None None XRAY 2.0 0.223 0.257 A 274.0 241.0 28 29 13 16 [[402, 653]] 1.0 3pj1 TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 1K2PB Q06187 397 654 659.0 No_ligand No_ligand Inactive DFGin 6.457 13.1625 BLBplus -139.6, -161.19 59.0, 26.74 -105.15, 158.18 56.54, 91.73 152.19, -71.86 out-out out 12.9943 Saltbr-out 10.301 HRD-in -87.21, -28.6 73.87, -41.31 out-in-out SNCoio in-out ActLoopNT-in 2.7353 ActLoopCT-out TYR APEdihe_iioao APEdist_aaai APE10-dihe-in -120.27, 103.13 APE9-dihe-in -86.88, 165.1 APE8-dihe-out -60.59, -22.28 APE8-rot-na 27.98 APE67-dihe-out -58.09, -40.25 73.96, -61.99 APE12-dist-na 16.6499 APE11-dist-na 13.4797 APE10-dist-na 16.127 APE9-dist-in 7.2691 None None None XRAY 2.1 0.28 0.287 B 263.0 258.0 0 29 29 0 [[402, 653]] 1.0 1k2p TYR_BTK_HUMAN TYR 5.4e-93 317.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 8YVVA Q06187 394 658 659.0 No_ligand No_ligand Inactive DFGin 5.9975 13.8277 BLBplus -134.73, -178.16 59.38, 44.59 -109.86, 142.64 55.87, 84.85 77.65, -67.74 out-out out 14.3246 Saltbr-out 15.544 HRD-in -75.34, -58.82 89.51, -11.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -123.34, 14.3 APE9-dihe-in -77.59, 136.04 APE8-dihe-in -77.96, 72.48 APE8-rot-na 34.0 APE67-dihe-in -72.74, -9.49 -60.94, -40.0 APE12-dist-na 22.471 APE11-dist-na 19.5489 APE10-dist-na 15.1318 APE9-dist-out 8.4964 None None None XRAY 2.25 0.211 0.266 A 266.0 262.0 3 29 28 1 [[402, 653]] 1.0 8yvv TYR_BTK_HUMAN TYR 5.6e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 8YVVB Q06187 395 658 659.0 No_ligand No_ligand Inactive DFGin 6.0135 13.8585 BLBplus -134.8, -177.27 59.8, 43.75 -110.54, 141.4 55.94, 96.02 79.54, -66.86 out-out out 14.2328 Saltbr-out 14.8275 HRD-in -75.12, -58.7 89.76, -10.72 out-out-none SNCoon out-none ActLoopNT-out 12.1423 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 69.43 APE8-rot-na 32.53 APE67-dihe-in -73.72, -9.32 -60.74, -39.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.211 0.266 B 266.0 247.0 17 29 14 15 [[402, 653]] 1.0 8yvv TYR_BTK_HUMAN TYR 5.6e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 3P08A Q06187 394 658 659.0 No_ligand No_ligand Inactive DFGin 5.9549 13.9444 BLBplus -128.06, -177.49 61.21, 39.22 -106.08, 150.25 54.53, 96.35 80.6, -131.41 out-out out 14.116 Saltbr-out 14.9362 HRD-in -72.42, -56.09 86.22, -18.05 out-out-out SNCooo out-out ActLoopNT-out 9.5034 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -55.21 APE9-dihe-in -164.04, 136.13 APE8-dihe-in -66.05, 54.59 APE8-rot-na 27.48 APE67-dihe-in -71.49, -7.26 -51.24, -42.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 19.3141 APE9-dist-out 8.5786 None None None XRAY 2.3 0.228 0.278 A 267.0 252.0 13 29 16 13 [[402, 653]] 1.0 3p08 TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 3P08B Q06187 395 658 659.0 No_ligand No_ligand Inactive DFGin 5.9243 13.8923 BLBplus -127.17, -176.76 62.02, 37.83 -105.43, 144.29 55.2, 95.38 69.79, -51.59 out-out out 14.0388 Saltbr-out 15.0143 HRD-in -68.66, -56.62 86.42, -18.8 out-out-out SNCooo out-out ActLoopNT-out 10.4665 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.87 APE8-dihe-in -65.06, 55.73 APE8-rot-na 340.87 APE67-dihe-in -75.43, -6.18 -53.16, -39.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.4743 None None None XRAY 2.3 0.228 0.278 B 267.0 258.0 6 29 23 6 [[402, 653]] 1.0 3p08 TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6W8IA Q06187 393 657 659.0 No_ligand No_ligand Inactive DFGin 5.4944 13.1493 BLBplus -141.69, -178.02 52.95, 31.02 -75.34, 135.29 30.84, 76.13 77.64, -19.59 out-none out 11.5703 Saltbr-none 999.0 HRD-in -72.89, -30.35 63.34, -9.06 none-out-out SNCnoo out-out ActLoopNT-out 8.0199 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -49.9 APE9-dihe-in -70.68, 142.5 APE8-dihe-in -77.28, 76.89 APE8-rot-na 26.43 APE67-dihe-in -62.4, -20.85 -66.35, -47.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.3527 APE9-dist-out 8.7279 None None None XRAY 3.8 0.213 0.251 A 277.0 254.0 11 29 18 11 [[402, 653]] 1.0 6w8i TYR_BTK_HUMAN TYR 6.6e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6W8IB Q06187 395 657 659.0 No_ligand No_ligand Inactive DFGin 5.525 13.3295 BLBplus -125.64, 175.83 52.48, 26.01 -70.56, 126.21 48.5, 99.48 77.88, -23.39 out-out out 14.815 Saltbr-out 11.6934 HRD-in -73.94, -52.14 71.09, -15.22 out-out-out SNCooo out-out ActLoopNT-out 7.3025 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.0 APE8-dihe-in -77.84, 75.97 APE8-rot-na 24.72 APE67-dihe-in -59.64, -37.38 -63.18, -50.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.3414 None None None XRAY 3.8 0.213 0.251 B 277.0 251.0 12 29 17 12 [[402, 653]] 1.0 6w8i TYR_BTK_HUMAN TYR 6.6e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 4NWMA Q06187 396 657 659.0 2P5:60701 Type1 Inactive DFGin 6.2366 13.5473 BLBplus -124.36, 162.2 58.0, 30.8 -65.9, 131.67 37.39, 93.38 75.76, -5.81 out-none out 15.7388 Saltbr-none 999.0 HRD-in -75.22, -56.08 81.81, -11.35 none-out-out SNCnoo out-out ActLoopNT-out 7.4406 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -104.06, -3.18 APE9-dihe-in -62.5, 137.94 APE8-dihe-in -76.17, 67.69 APE8-rot-na 29.81 APE67-dihe-in -67.16, -10.51 -55.62, -44.66 APE12-dist-na 17.5081 APE11-dist-na 19.1435 APE10-dist-na 14.0443 APE9-dist-out 8.5218 None None OCS481 XRAY 2.03 0.197 0.234 A 263.0 261.0 1 29 29 0 [[402, 653]] 1.0 4nwm TYR_BTK_HUMAN TYR 5.4e-93 317.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 4NWMB Q06187 396 657 659.0 2P5:60701 Type1 Inactive DFGin 6.136 13.8027 BLBplus -123.62, 161.4 58.54, 30.74 -65.95, 131.21 37.43, 94.6 74.49, -3.43 out-none out 14.7614 Saltbr-none 999.0 HRD-in -74.43, -56.79 83.89, -12.84 none-out-out SNCnoo out-out ActLoopNT-out 7.4869 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -104.71, -3.65 APE9-dihe-in -64.14, 139.49 APE8-dihe-in -76.31, 69.39 APE8-rot-na 29.79 APE67-dihe-in -66.98, -8.96 -53.75, -47.41 APE12-dist-na 17.2896 APE11-dist-na 19.1988 APE10-dist-na 14.1826 APE9-dist-out 8.4816 None None OCS481 XRAY 2.03 0.197 0.234 B 263.0 261.0 1 29 29 0 [[402, 653]] 1.0 4nwm TYR_BTK_HUMAN TYR 5.4e-93 317.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6AUBA Q06187 395 657 659.0 BXM:60703 Type1 Inactive DFGin 6.181 13.7035 BLBplus -120.63, 149.92 61.48, 31.96 -57.12, 132.62 37.58, 95.01 82.18, -15.5 out-out out 16.4107 Saltbr-out 16.4116 HRD-in -73.54, -57.51 84.74, -16.58 out-out-out SNCooo out-out ActLoopNT-out 7.6247 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -104.04, -6.45 APE9-dihe-in -61.75, 141.0 APE8-dihe-in -78.36, 61.51 APE8-rot-na 29.02 APE67-dihe-in -70.89, -7.8 -56.63, -43.29 APE12-dist-na 17.6153 APE11-dist-na 19.0984 APE10-dist-na 13.8646 APE9-dist-out 8.5418 None None None XRAY 1.65 0.166 0.199 A 264.0 263.0 0 29 29 0 [[402, 653]] 1.0 6aub TYR_BTK_HUMAN TYR 5.5e-93 317.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6S90A Q06187 395 656 659.0 L0Z:701 Type1 Inactive DFGin 6.1122 13.79 BLBplus -115.31, 156.37 55.47, 33.74 -62.04, 130.58 34.96, 96.83 75.01, -11.68 out-out out 16.0674 Saltbr-out 16.1976 HRD-in -72.51, -52.76 82.17, -15.84 out-out-out SNCooo out-out ActLoopNT-out 7.4778 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -106.99, -6.85 APE9-dihe-in -64.19, 138.56 APE8-dihe-in -76.5, 60.12 APE8-rot-na 32.24 APE67-dihe-in -73.04, -6.49 -53.3, -46.98 APE12-dist-na 17.3407 APE11-dist-na 18.6749 APE10-dist-na 13.5553 APE9-dist-out 8.3686 None None None XRAY 1.82 0.169 0.201 A 266.0 262.0 0 29 29 0 [[402, 653]] 1.0 6s90 TYR_BTK_HUMAN TYR 5.6e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6S90B Q06187 395 656 659.0 L0Z:701 Type1 Inactive DFGin 6.1085 13.8622 BLBplus -116.19, 155.66 56.11, 33.52 -61.22, 131.45 35.37, 97.17 75.29, -12.88 out-out out 16.087 Saltbr-out 16.1894 HRD-in -72.06, -53.36 83.12, -14.11 out-out-out SNCooo out-out ActLoopNT-out 7.4687 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -104.9, -7.1 APE9-dihe-in -63.27, 138.96 APE8-dihe-in -77.53, 59.25 APE8-rot-na 32.06 APE67-dihe-in -69.99, -10.14 -54.04, -43.78 APE12-dist-na 17.3739 APE11-dist-na 18.7144 APE10-dist-na 13.5827 APE9-dist-out 8.3819 None None None XRAY 1.82 0.169 0.201 B 266.0 262.0 0 29 29 0 [[402, 653]] 1.0 6s90 TYR_BTK_HUMAN TYR 5.6e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5BPYA Q06187 396 657 659.0 4UQ:64000 Type1 Inactive DFGin 6.3602 13.3055 BLBplus -124.65, 164.88 51.29, 37.75 -70.0, 127.36 35.13, 98.17 69.78, 12.96 out-out out 15.0418 Saltbr-out 16.1326 HRD-in -71.75, -58.49 82.06, -15.91 out-out-out SNCooo out-out ActLoopNT-out 7.8951 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.29, -6.51 APE9-dihe-in -62.22, 139.35 APE8-dihe-in -81.26, 69.56 APE8-rot-na 30.14 APE67-dihe-in -66.47, -13.16 -61.31, -41.9 APE12-dist-na 17.2653 APE11-dist-na 19.274 APE10-dist-na 14.23 APE9-dist-out 8.7636 None None None XRAY 2.31 0.215 0.242 A 267.0 262.0 0 29 29 0 [[402, 653]] 1.0 5bpy TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5BPYB Q06187 396 657 659.0 4UQ:64000 Type1 Inactive DFGin 6.0407 13.3553 BLBplus -124.21, 164.45 49.48, 38.96 -70.05, 125.98 33.54, 98.82 68.93, 10.8 out-none out 14.6981 Saltbr-none 999.0 HRD-in -73.63, -56.78 81.23, -14.54 none-out-out SNCnoo out-out ActLoopNT-out 7.9375 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -33.35 APE9-dihe-out -59.81, -45.04 APE8-dihe-out -62.46, 0.27 APE8-rot-na 341.31 APE67-dihe-in -65.96, -13.01 -56.63, -35.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.1618 APE9-dist-out 11.0675 None None None XRAY 2.31 0.215 0.242 B 267.0 246.0 16 29 18 11 [[402, 653]] 1.0 5bpy TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5JRSA Q06187 396 656 659.0 6MV:64000 Type1 Inactive DFGin 6.0609 13.3395 BLBplus -124.69, 170.12 55.97, 34.2 -67.63, 128.46 35.86, 96.69 69.73, 6.07 out-out out 14.9306 Saltbr-out 13.2279 HRD-in -69.99, -56.03 84.33, -14.06 out-out-out SNCooo out-out ActLoopNT-out 7.7446 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.56, 5.66 APE9-dihe-in -66.64, 144.44 APE8-dihe-in -83.22, 65.57 APE8-rot-na 33.78 APE67-dihe-in -68.72, -13.46 -60.6, -36.2 APE12-dist-na 17.2392 APE11-dist-na 19.1688 APE10-dist-na 14.3888 APE9-dist-out 8.7529 None None None XRAY 1.97 0.203 0.226 A 267.0 257.0 4 29 29 0 [[402, 653]] 1.0 5jrs TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5JRSB Q06187 396 655 659.0 6MV:64000 Type1 Inactive DFGin 5.9654 13.4845 BLBplus -124.08, 170.99 56.24, 32.66 -67.77, 127.61 36.28, 96.89 68.67, 6.72 out-none out 14.8868 Saltbr-none 999.0 HRD-in -69.59, -54.99 82.87, -12.35 none-out-out SNCnoo out-out ActLoopNT-out 7.8699 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -43.7 APE9-dihe-out -53.67, -38.72 APE8-dihe-out -66.14, 0.13 APE8-rot-na 344.61 APE67-dihe-in -68.32, -13.38 -53.75, -36.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 17.8185 APE9-dist-out 11.039 None None None XRAY 1.97 0.203 0.226 B 267.0 239.0 21 29 18 11 [[402, 653]] 1.0 5jrs TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5T18A Q06187 396 658 659.0 73T:60701 Type1 Inactive DFGin 6.0396 13.7879 BLBplus -128.43, 165.54 60.99, 25.86 -63.42, 127.88 36.69, 97.91 80.59, -10.26 out-out out 14.9141 Saltbr-out 15.5279 HRD-in -71.94, -54.27 84.17, -17.74 out-out-out SNCooo out-out ActLoopNT-out 7.7017 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -113.6, 4.76 APE9-dihe-in -68.35, 140.21 APE8-dihe-in -81.87, 60.04 APE8-rot-na 32.7 APE67-dihe-in -71.98, -10.48 -52.94, -39.23 APE12-dist-na 17.4513 APE11-dist-na 18.9457 APE10-dist-na 13.9709 APE9-dist-out 9.2696 None None None XRAY 1.5 0.204 0.223 A 267.0 259.0 4 29 29 0 [[402, 653]] 1.0 5t18 TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7KXNA Q06187 394 659 659.0 X9P:701 Type1 Inactive DFGin 6.3685 13.7083 BLBplus -122.57, 148.94 62.24, 33.0 -62.58, 131.94 36.11, 94.82 84.8, -17.54 out-out out 14.3666 Saltbr-out 15.1599 HRD-in -72.47, -54.42 85.13, -15.06 out-out-out SNCooo out-out ActLoopNT-out 7.9007 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -108.58, 2.74 APE9-dihe-in -69.58, 141.22 APE8-dihe-in -79.75, 64.14 APE8-rot-na 28.99 APE67-dihe-in -72.75, -5.53 -54.22, -44.59 APE12-dist-na 17.4074 APE11-dist-na 18.9131 APE10-dist-na 13.9573 APE9-dist-out 8.6741 None None None XRAY 1.34 0.167 0.197 A 267.0 266.0 0 29 29 0 [[402, 653]] 1.0 7kxn TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7KXOA Q06187 395 659 659.0 X9S:701 Type1 Inactive DFGin 6.3799 13.7442 BLBplus -120.11, 148.11 62.72, 27.77 -59.03, 136.32 33.69, 94.97 76.45, -12.5 out-out out 14.4052 Saltbr-out 15.3218 HRD-in -75.54, -53.57 78.37, -10.38 out-out-out SNCooo out-out ActLoopNT-out 7.8705 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -108.02, -0.92 APE9-dihe-in -67.7, 140.58 APE8-dihe-in -76.71, 60.46 APE8-rot-na 27.44 APE67-dihe-in -76.26, -4.56 -54.52, -42.77 APE12-dist-na 17.3677 APE11-dist-na 18.7268 APE10-dist-na 13.7872 APE9-dist-out 8.4989 None None None XRAY 1.94 0.205 0.248 A 267.0 265.0 0 29 29 0 [[402, 653]] 1.0 7kxo TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7LTYA Q06187 393 658 659.0 YD7:701 Type1 Inactive DFGin 6.0398 13.8841 BLBplus -120.46, 149.15 59.16, 35.87 -61.84, 129.93 32.98, 96.93 84.41, -11.31 out-out out 14.4917 Saltbr-out 15.1964 HRD-in -69.98, -53.95 85.82, -17.9 out-out-out SNCooo out-out ActLoopNT-out 8.131 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.14 APE8-dihe-in -80.21, 65.2 APE8-rot-na 34.31 APE67-dihe-in -75.46, -7.66 -50.97, -45.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0195 None None None XRAY 1.69 0.179 0.208 A 267.0 255.0 11 29 18 11 [[402, 653]] 1.0 7lty TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7LTZA Q06187 394 658 659.0 YDA:701 Type1 Inactive DFGin 6.4478 13.6817 BLBplus -121.71, 151.81 61.43, 29.86 -61.8, 132.15 35.67, 95.63 82.97, -15.81 out-out out 14.383 Saltbr-out 14.8545 HRD-in -72.37, -53.05 82.26, -9.58 out-out-out SNCooo out-out ActLoopNT-out 7.9097 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -106.64, -0.65 APE9-dihe-in -68.21, 140.78 APE8-dihe-in -77.46, 63.64 APE8-rot-na 28.65 APE67-dihe-in -71.62, -8.73 -54.28, -47.48 APE12-dist-na 17.493 APE11-dist-na 18.8132 APE10-dist-na 13.7376 APE9-dist-out 8.5926 None None None XRAY 1.53 0.181 0.213 A 267.0 265.0 0 29 29 0 [[402, 653]] 1.0 7ltz TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7KXLA Q06187 392 658 659.0 X9J:701 Type1 Inactive DFGin 6.0553 13.81 BLBplus -115.19, 156.74 57.55, 31.61 -63.72, 128.43 43.5, 92.5 74.31, -4.58 out-out out 14.3879 Saltbr-out 14.9167 HRD-in -74.96, -55.95 81.49, -10.63 out-out-out SNCooo out-out ActLoopNT-out 7.9012 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.76, -4.08 APE9-dihe-in -65.01, 139.63 APE8-dihe-in -78.45, 60.79 APE8-rot-na 30.76 APE67-dihe-in -67.47, -10.24 -48.14, -50.89 APE12-dist-na 17.4726 APE11-dist-na 18.8749 APE10-dist-na 13.8193 APE9-dist-out 8.4261 None None None XRAY 1.84 0.2 0.229 A 268.0 267.0 0 29 29 0 [[402, 653]] 1.0 7kxl TYR_BTK_HUMAN TYR 5.8e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5ZZ4A Q06187 395 655 659.0 9M3:701 Type1 Inactive DFGin 6.216 13.9816 BLBplus -111.98, 145.41 64.78, 44.4 -74.28, 132.13 32.68, 105.17 78.32, -10.69 out-none out 16.4373 Saltbr-none 999.0 HRD-in -67.71, -61.96 75.17, -0.36 none-out-out SNCnoo out-out ActLoopNT-out 7.2672 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -92.49, -1.0 APE9-dihe-in -77.31, 154.21 APE8-dihe-in -78.66, 60.05 APE8-rot-na 35.97 APE67-dihe-in -57.31, -13.94 -55.76, -59.34 APE12-dist-na 17.6748 APE11-dist-na 19.2789 APE10-dist-na 14.3435 APE9-dist-out 8.53 None None None XRAY 2.9 0.227 0.317 A 268.0 261.0 0 29 29 0 [[402, 653]] 1.0 5zz4 TYR_BTK_HUMAN TYR 5.8e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5ZZ4B Q06187 393 655 659.0 9M3:701 Type1 Inactive DFGin 6.3634 14.2651 BLBplus -109.91, 138.99 65.73, 42.72 -63.28, 144.19 29.05, 106.93 50.75, 21.21 out-out out 17.3213 Saltbr-out 17.0637 HRD-in -73.01, -58.9 82.89, -15.47 out-out-out SNCooo out-out ActLoopNT-out 7.3802 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -97.75, -7.06 APE9-dihe-in -70.79, 144.21 APE8-dihe-in -75.36, 52.84 APE8-rot-na 31.73 APE67-dihe-in -64.34, -20.03 -47.19, -52.63 APE12-dist-na 17.8007 APE11-dist-na 19.0818 APE10-dist-na 14.1976 APE9-dist-out 8.5838 None None None XRAY 2.9 0.227 0.317 B 268.0 263.0 0 29 29 0 [[402, 653]] 1.0 5zz4 TYR_BTK_HUMAN TYR 5.8e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5ZZ4C Q06187 394 655 659.0 9M3:701 Type1 Inactive DFGin 6.2805 14.0992 BLBplus -104.98, 150.07 61.01, 37.07 -61.77, 143.5 31.71, 121.26 50.22, 21.27 out-none out 17.295 Saltbr-none 999.0 HRD-in -60.21, -60.2 78.75, -7.3 none-out-out SNCnoo out-out ActLoopNT-out 7.264 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -87.41, -7.6 APE9-dihe-in -66.98, 152.21 APE8-dihe-in -84.69, 62.42 APE8-rot-na 38.55 APE67-dihe-in -56.47, -17.05 -55.47, -54.33 APE12-dist-na 17.8283 APE11-dist-na 19.1946 APE10-dist-na 14.3144 APE9-dist-out 8.744 None None None XRAY 2.9 0.227 0.317 C 268.0 262.0 0 29 29 0 [[402, 653]] 1.0 5zz4 TYR_BTK_HUMAN TYR 5.8e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5ZZ4D Q06187 393 655 659.0 9M3:701 Type1 Inactive DFGin 6.4453 14.1097 BLBplus -100.32, 149.86 51.9, 44.48 -65.1, 145.39 31.68, 111.22 66.68, 4.44 out-none out 16.7285 Saltbr-none 999.0 HRD-in -71.61, -60.83 82.15, -8.13 none-out-out SNCnoo out-out ActLoopNT-out 7.5175 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -121.96, -10.28 APE9-dihe-in -74.58, 151.07 APE8-dihe-in -81.06, 54.54 APE8-rot-na 34.38 APE67-dihe-in -63.51, -13.9 -54.63, -46.8 APE12-dist-na 17.6647 APE11-dist-na 19.5409 APE10-dist-na 14.4737 APE9-dist-out 8.6596 None None None XRAY 2.9 0.227 0.317 D 268.0 263.0 0 29 29 0 [[402, 653]] 1.0 5zz4 TYR_BTK_HUMAN TYR 5.8e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5ZZ4E Q06187 394 655 659.0 9M3:701 Type1 Inactive DFGin 6.3694 14.1758 BLBplus -106.76, 160.23 63.16, 34.1 -66.11, 143.33 39.49, 104.71 65.03, 2.18 out-out out 16.8801 Saltbr-out 13.6071 HRD-in -60.44, -55.43 77.7, -19.27 out-out-out SNCooo out-out ActLoopNT-out 7.2255 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -89.94, -8.41 APE9-dihe-in -70.93, 148.48 APE8-dihe-in -79.4, 54.28 APE8-rot-na 35.37 APE67-dihe-in -59.43, -11.62 -47.13, -55.11 APE12-dist-na 17.7365 APE11-dist-na 19.4324 APE10-dist-na 14.3472 APE9-dist-out 8.8482 None None None XRAY 2.9 0.227 0.317 E 268.0 262.0 0 29 29 0 [[402, 653]] 1.0 5zz4 TYR_BTK_HUMAN TYR 5.8e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5ZZ4F Q06187 393 655 659.0 9M3:701 Type1 Inactive DFGin 6.5852 13.8504 BLBplus -109.5, 156.48 68.48, 31.68 -62.49, 139.7 30.55, 118.72 67.4, 2.97 out-none out 16.676 Saltbr-none 999.0 HRD-in -67.31, -62.62 74.22, 1.9 none-out-out SNCnoo out-out ActLoopNT-out 7.3474 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.02, 7.66 APE9-dihe-in -87.4, 149.21 APE8-dihe-in -71.07, 57.28 APE8-rot-na 25.91 APE67-dihe-in -61.15, -9.98 -57.23, -56.36 APE12-dist-na 17.4812 APE11-dist-na 19.2176 APE10-dist-na 14.2372 APE9-dist-out 8.5921 None None None XRAY 2.9 0.227 0.317 F 268.0 263.0 0 29 29 0 [[402, 653]] 1.0 5zz4 TYR_BTK_HUMAN TYR 5.8e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6O8IA Q06187 391 658 659.0 LTJ:4000 Type1 Inactive DFGin 5.5354 14.972 BLBplus -129.8, -155.21 58.3, 44.54 -137.09, 133.38 65.53, 96.57 62.04, -135.93 out-out out 11.7759 Saltbr-out 14.169 HRD-in -73.8, -50.46 77.78, -9.81 out-out-out SNCooo out-out ActLoopNT-out 11.6693 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -85.73, 87.18 APE9-dihe-in -85.79, 141.41 APE8-dihe-in -78.4, 64.22 APE8-rot-na 30.1 APE67-dihe-in -70.0, -10.62 -49.55, -46.25 APE12-dist-na 16.2014 APE11-dist-na 19.9778 APE10-dist-na 18.3131 APE9-dist-out 8.2749 None None None XRAY 1.42 0.195 0.222 A 269.0 260.0 8 29 29 0 [[402, 653]] 1.0 6o8i TYR_BTK_HUMAN TYR 5.9e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7N4QA Q06187 392 658 659.0 0B9:701 Type1 Inactive DFGin 6.3971 14.1185 BLBplus -122.39, 161.75 60.23, 32.62 -65.83, 123.81 35.6, 99.1 82.08, -3.68 out-out out 14.9072 Saltbr-out 15.0285 HRD-in -69.31, -52.59 79.69, -10.12 out-out-out SNCooo out-out ActLoopNT-out 8.1292 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -122.02, 17.35 APE9-dihe-in -74.51, 145.27 APE8-dihe-in -76.82, 64.99 APE8-rot-na 26.09 APE67-dihe-in -72.23, -8.19 -50.78, -45.54 APE12-dist-na 16.7811 APE11-dist-na 18.9095 APE10-dist-na 14.1374 APE9-dist-out 8.7807 None None None XRAY 1.5 0.19 0.22 A 269.0 260.0 7 29 22 7 [[402, 653]] 1.0 7n4q TYR_BTK_HUMAN TYR 5.9e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7N4RA Q06187 393 658 659.0 0BG:701 Type1 Inactive DFGin 6.6442 13.591 BLBplus -121.88, 151.91 59.51, 33.13 -66.38, 128.39 34.2, 97.49 85.55, -12.93 out-out out 14.6027 Saltbr-out 14.5917 HRD-in -66.86, -50.22 79.11, -13.03 out-out-out SNCooo out-out ActLoopNT-out 8.1255 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 9.87 APE9-dihe-in -72.51, 150.22 APE8-dihe-in -80.29, 61.71 APE8-rot-na 33.0 APE67-dihe-in -75.91, -4.86 -49.09, -45.45 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.9207 APE9-dist-out 8.5637 None None None XRAY 1.62 0.194 0.222 A 269.0 257.0 9 29 20 9 [[402, 653]] 1.0 7n4r TYR_BTK_HUMAN TYR 5.9e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7N4SA Q06187 394 658 659.0 0B0:701 Type1 Inactive DFGin 5.8001 13.9364 BLBplus -122.05, 156.1 62.66, 32.76 -66.63, 129.34 36.7, 93.58 75.05, 4.48 out-out out 15.3953 Saltbr-out 15.6555 HRD-in -79.25, -45.64 74.9, -11.58 out-out-out SNCooo out-out ActLoopNT-out 8.105 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.81, 4.43 APE9-dihe-in -71.06, 136.98 APE8-dihe-in -70.71, 71.79 APE8-rot-na 16.05 APE67-dihe-in -70.12, -9.25 -59.1, -43.07 APE12-dist-na 999.0 APE11-dist-na 18.2877 APE10-dist-na 13.6886 APE9-dist-out 8.5751 None None None XRAY 2.05 0.245 0.276 A 269.0 257.0 8 29 21 8 [[402, 653]] 1.0 7n4s TYR_BTK_HUMAN TYR 5.9e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 4RX5A Q06187 394 657 659.0 3YO:60706 Type1 Inactive DFGin 6.1509 13.7538 BLBplus -119.61, 155.3 63.7, 23.65 -58.56, 129.53 37.72, 94.55 82.48, -13.46 out-out out 16.0169 Saltbr-out 16.2541 HRD-in -71.68, -55.75 80.97, -13.81 out-out-out SNCooo out-out ActLoopNT-out 7.5177 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.63, -6.43 APE9-dihe-in -63.26, 139.9 APE8-dihe-in -79.02, 60.45 APE8-rot-na 28.53 APE67-dihe-in -70.61, -10.64 -53.72, -41.1 APE12-dist-na 17.6828 APE11-dist-na 19.4317 APE10-dist-na 14.1078 APE9-dist-out 8.6708 None None None XRAY 1.356 0.161 0.179 A 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 4rx5 TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5KUPA Q06187 394 657 659.0 6XL:60706 Type1 Inactive DFGin 6.2956 13.7472 BLBplus -121.84, 153.05 63.8, 26.94 -58.44, 133.71 38.07, 94.47 79.47, -12.97 out-out out 16.2267 Saltbr-out 16.085 HRD-in -69.81, -54.6 79.56, -14.26 out-out-out SNCooo out-out ActLoopNT-out 7.6659 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.61, -4.77 APE9-dihe-in -65.98, 139.47 APE8-dihe-in -77.7, 59.33 APE8-rot-na 29.77 APE67-dihe-in -70.19, -9.37 -54.33, -41.62 APE12-dist-na 17.7421 APE11-dist-na 19.533 APE10-dist-na 14.1705 APE9-dist-out 8.7926 None None None XRAY 1.389 0.166 0.177 A 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 5kup TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5VGOA Q06187 394 657 659.0 9B1:60707 Type1 Inactive DFGin 6.2976 13.7236 BLBplus -124.76, 153.57 59.44, 28.24 -58.41, 134.91 40.66, 94.7 81.7, -15.25 out-out out 16.2462 Saltbr-out 16.3337 HRD-in -75.44, -56.53 79.92, -9.42 out-out-out SNCooo out-out ActLoopNT-out 7.6431 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -105.93, -6.17 APE9-dihe-in -64.13, 137.95 APE8-dihe-in -77.1, 60.07 APE8-rot-na 30.41 APE67-dihe-in -71.15, -9.42 -53.89, -41.55 APE12-dist-na 17.6088 APE11-dist-na 19.3082 APE10-dist-na 14.0442 APE9-dist-out 8.6423 None None None XRAY 1.621 0.162 0.184 A 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 5vgo TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7KXQA Q06187 390 659 659.0 X9Y:703 Type1 Inactive DFGin 6.2549 13.7675 BLBplus -126.01, 147.88 61.52, 30.89 -60.2, 130.5 35.64, 94.85 85.11, -16.52 out-out out 14.2933 Saltbr-out 14.8214 HRD-in -75.06, -57.63 85.91, -13.2 out-out-out SNCooo out-out ActLoopNT-out 7.8389 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.85, 1.09 APE9-dihe-in -69.41, 138.95 APE8-dihe-in -78.42, 60.95 APE8-rot-na 30.16 APE67-dihe-in -73.09, -6.69 -50.35, -45.55 APE12-dist-na 17.3268 APE11-dist-na 18.7507 APE10-dist-na 13.7945 APE9-dist-out 8.458 None None None XRAY 1.38 0.154 0.182 A 270.0 270.0 0 29 29 0 [[402, 653]] 1.0 7kxq TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 3OCSA Q06187 395 656 659.0 746:60999 Type1 Inactive DFGin 6.2221 13.6312 BLBplus -114.93, 147.94 62.96, 29.79 -55.44, 130.74 36.97, 95.37 87.07, -21.36 out-none out 16.4267 Saltbr-none 999.0 HRD-in -76.09, -57.01 85.33, -17.49 none-out-out SNCnoo out-out ActLoopNT-out 7.6466 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.37, -6.26 APE9-dihe-in -68.03, 138.81 APE8-dihe-in -76.92, 61.1 APE8-rot-na 27.82 APE67-dihe-in -69.57, -9.84 -52.96, -47.05 APE12-dist-na 17.4303 APE11-dist-na 19.0778 APE10-dist-na 13.7719 APE9-dist-out 8.4504 None None None XRAY 1.8 0.184 0.213 A 271.0 262.0 0 29 29 0 [[402, 653]] 1.0 3ocs TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 4OTFA Q06187 396 657 659.0 2VL:60704 Type1 Inactive DFGin 6.1809 13.7558 BLBplus -118.16, 151.16 61.72, 28.57 -55.11, 129.8 38.1, 96.01 83.0, -13.47 out-out out 16.4557 Saltbr-out 16.2069 HRD-in -75.92, -56.91 83.51, -16.44 out-out-out SNCooo out-out ActLoopNT-out 7.7345 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.77, -4.68 APE9-dihe-in -64.45, 137.09 APE8-dihe-in -77.9, 61.16 APE8-rot-na 31.4 APE67-dihe-in -69.89, -12.66 -52.32, -42.22 APE12-dist-na 17.474 APE11-dist-na 19.1296 APE10-dist-na 13.8482 APE9-dist-out 8.5545 None None OCS481 XRAY 1.95 0.167 0.203 A 271.0 262.0 0 29 29 0 [[402, 653]] 1.0 4otf TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 4ZLYA Q06187 389 658 659.0 4RU:705 Type1 Inactive DFGin 5.9412 13.5981 BLBplus -121.18, 160.02 59.56, 31.08 -62.35, 130.02 31.68, 94.98 79.06, -10.8 out-out out 14.6598 Saltbr-out 14.8697 HRD-in -71.97, -48.27 77.4, -11.56 out-out-out SNCooo out-out ActLoopNT-out 8.1494 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -118.15, 9.43 APE9-dihe-in -68.3, 142.82 APE8-dihe-in -77.25, 62.27 APE8-rot-na 27.81 APE67-dihe-in -73.91, -8.89 -51.8, -41.84 APE12-dist-na 17.2087 APE11-dist-na 19.1134 APE10-dist-na 14.2942 APE9-dist-out 9.0104 None None None XRAY 1.65 0.165 0.197 A 270.0 270.0 0 29 29 0 [[402, 653]] 1.0 4zly TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 4ZLZA Q06187 389 658 659.0 4RV:705 Type1 Inactive DFGin 6.2531 13.2938 BLBplus -122.49, 170.08 52.61, 30.14 -62.21, 131.07 34.71, 101.16 74.57, -3.58 out-out out 14.459 Saltbr-out 14.9983 HRD-in -65.3, -50.04 78.77, -11.8 out-out-out SNCooo out-out ActLoopNT-out 8.0339 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -112.73, 3.53 APE9-dihe-in -65.61, 144.48 APE8-dihe-in -79.64, 61.07 APE8-rot-na 29.52 APE67-dihe-in -68.16, -13.9 -50.41, -45.39 APE12-dist-na 17.2074 APE11-dist-na 19.0726 APE10-dist-na 14.1434 APE9-dist-out 9.0698 None None None XRAY 2.0 0.179 0.241 A 270.0 270.0 0 29 29 0 [[402, 653]] 1.0 4zlz TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 8GC7A Q06187 389 658 659.0 YXJ:701 Type1 Inactive DFGin 5.6598 13.9628 BLBplus -123.08, 158.81 53.31, 37.71 -60.57, 129.19 31.38, 95.07 80.32, -8.0 out-out out 14.8859 Saltbr-out 15.5036 HRD-in -76.19, -49.65 80.71, -9.04 out-out-out SNCooo out-out ActLoopNT-out 8.2683 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -113.49, 3.29 APE9-dihe-in -66.04, 143.07 APE8-dihe-in -74.0, 58.89 APE8-rot-na 25.36 APE67-dihe-in -71.36, -7.54 -54.52, -45.09 APE12-dist-na 17.2668 APE11-dist-na 18.8132 APE10-dist-na 13.9629 APE9-dist-out 8.7982 None None None XRAY 1.9 0.195 0.227 A 270.0 270.0 0 29 29 0 [[402, 653]] 1.0 8gc7 TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 8U2DA Q06187 389 658 659.0 UQX:701 Type1 Inactive DFGin 7.1017 13.2298 BLBplus -128.23, 153.12 56.97, 29.42 -62.44, 128.51 31.85, 99.81 83.8, -5.53 out-out out 14.7563 Saltbr-out 15.0744 HRD-in -72.87, -50.82 82.88, -13.96 out-out-out SNCooo out-out ActLoopNT-out 8.0979 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -113.19, 3.51 APE9-dihe-in -71.67, 146.89 APE8-dihe-in -77.7, 65.34 APE8-rot-na 28.87 APE67-dihe-in -74.92, -7.55 -56.99, -42.42 APE12-dist-na 16.9189 APE11-dist-na 18.7168 APE10-dist-na 13.7531 APE9-dist-out 8.5231 None None None XRAY 1.95 0.193 0.238 A 270.0 270.0 0 29 29 0 [[402, 653]] 1.0 8u2d TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 8U2EA Q06187 389 658 659.0 UP9:701 Type1 Inactive DFGin 6.0351 13.7892 BLBplus -127.58, 160.55 59.05, 29.98 -57.52, 130.4 29.31, 94.56 75.81, -4.4 out-out out 14.7822 Saltbr-out 15.5044 HRD-in -77.1, -53.33 80.92, -10.78 out-out-out SNCooo out-out ActLoopNT-out 8.1939 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -112.67, -1.09 APE9-dihe-in -65.62, 144.23 APE8-dihe-in -80.07, 66.77 APE8-rot-na 30.11 APE67-dihe-in -75.14, -6.63 -56.97, -42.88 APE12-dist-na 17.3026 APE11-dist-na 18.8593 APE10-dist-na 13.7868 APE9-dist-out 8.6931 None None None XRAY 1.9 0.193 0.238 A 270.0 270.0 0 29 29 0 [[402, 653]] 1.0 8u2e TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5U9DA Q06187 389 659 659.0 83P:701 Type1 Inactive DFGin 6.7004 13.116 BLBplus -123.64, 150.09 55.97, 32.63 -63.54, 131.47 34.45, 103.74 78.09, -3.54 out-out out 14.2631 Saltbr-out 14.8107 HRD-in -67.17, -50.39 78.01, -10.04 out-out-out SNCooo out-out ActLoopNT-out 8.1234 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.17, 9.75 APE9-dihe-in -69.32, 141.87 APE8-dihe-in -78.71, 66.26 APE8-rot-na 32.23 APE67-dihe-in -72.99, -7.55 -56.98, -43.33 APE12-dist-na 16.7205 APE11-dist-na 18.5344 APE10-dist-na 13.6493 APE9-dist-out 8.556 None None None XRAY 1.33 0.151 0.178 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 5u9d TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5VFIA Q06187 389 659 659.0 9AJ:701 Type1 Inactive DFGin 6.5486 13.7613 BLBplus -143.36, 153.96 60.49, 23.59 -61.26, 135.3 42.85, 92.4 77.99, -13.58 out-out out 14.4232 Saltbr-out 14.9707 HRD-in -71.46, -59.58 77.98, -9.84 out-out-out SNCooo out-out ActLoopNT-out 7.9475 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -110.2, -1.65 APE9-dihe-in -67.19, 139.63 APE8-dihe-in -76.43, 58.0 APE8-rot-na 29.74 APE67-dihe-in -70.96, -8.66 -49.99, -48.99 APE12-dist-na 17.2786 APE11-dist-na 18.5334 APE10-dist-na 13.6333 APE9-dist-out 8.36 None None None XRAY 1.59 0.189 0.216 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 5vfi TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6DI0A Q06187 389 659 659.0 GJG:701 Type1 Inactive DFGin 6.001 13.4805 BLBplus -124.53, 155.05 55.99, 32.11 -59.72, 127.96 33.47, 95.09 76.24, -5.83 out-out out 14.5371 Saltbr-out 14.8977 HRD-in -71.27, -49.47 78.19, -10.98 out-out-out SNCooo out-out ActLoopNT-out 8.1761 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -120.35, 18.42 APE9-dihe-in -71.2, 144.69 APE8-dihe-in -78.31, 63.76 APE8-rot-na 23.97 APE67-dihe-in -70.97, -7.34 -53.14, -44.3 APE12-dist-na 17.0042 APE11-dist-na 19.0119 APE10-dist-na 14.4067 APE9-dist-out 8.9062 None None None XRAY 1.3 0.18 0.202 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 6di0 TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6DI1A Q06187 389 659 659.0 GJD:701 Type1 Inactive DFGin 6.2305 13.4862 BLBplus -129.14, 171.13 57.85, 25.92 -61.75, 129.84 37.28, 94.65 77.09, -10.81 out-out out 14.5685 Saltbr-out 14.4879 HRD-in -69.39, -51.57 79.83, -12.8 out-out-out SNCooo out-out ActLoopNT-out 8.1849 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -115.3, 12.92 APE9-dihe-in -67.7, 143.91 APE8-dihe-in -78.96, 63.72 APE8-rot-na 24.89 APE67-dihe-in -71.41, -7.04 -52.39, -43.7 APE12-dist-na 16.9326 APE11-dist-na 19.0324 APE10-dist-na 14.3263 APE9-dist-out 8.9973 None None None XRAY 1.1 0.174 0.186 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 6di1 TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6DI9A Q06187 392 659 659.0 GJJ:701 Type1 Inactive DFGin 6.1303 13.648 BLBplus -124.28, 163.6 63.95, 24.4 -60.78, 124.97 34.06, 99.32 80.75, -11.12 out-none out 14.6651 Saltbr-none 999.0 HRD-in -70.18, -51.73 78.49, -12.84 none-out-out SNCnoo out-out ActLoopNT-out 8.1927 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 21.73 APE9-dihe-in -69.29, 145.05 APE8-dihe-in -84.76, 65.19 APE8-rot-na 29.95 APE67-dihe-in -73.47, -7.76 -50.52, -43.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.8553 APE9-dist-out 8.7836 None None None XRAY 1.25 0.194 0.207 A 271.0 252.0 16 29 19 10 [[402, 653]] 1.0 6di9 TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6NFHA Q06187 389 659 659.0 KLM:701 Type1 Inactive DFGin 5.6079 13.7659 BLBplus -122.24, 167.43 56.46, 32.17 -63.92, 123.57 34.29, 93.69 76.16, -3.03 out-out out 14.414 Saltbr-out 15.0093 HRD-in -72.27, -50.37 78.42, -8.53 out-out-out SNCooo out-out ActLoopNT-out 8.2846 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -124.53, 20.7 APE9-dihe-in -70.48, 146.89 APE8-dihe-in -82.32, 66.08 APE8-rot-na 28.28 APE67-dihe-in -74.58, -9.13 -54.47, -43.06 APE12-dist-na 16.9382 APE11-dist-na 18.9631 APE10-dist-na 14.2595 APE9-dist-out 8.8859 None None None XRAY 1.4 0.16 0.205 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 6nfh TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7KXMA Q06187 389 659 659.0 X9M:701 Type1 Inactive DFGin 6.3052 13.843 BLBplus -121.85, 153.64 56.09, 34.54 -59.98, 133.3 35.17, 95.47 76.06, -13.01 out-out out 14.6261 Saltbr-out 14.8271 HRD-in -72.42, -51.07 84.95, -19.15 out-out-out SNCooo out-out ActLoopNT-out 7.9372 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -109.49, -3.77 APE9-dihe-in -64.16, 140.71 APE8-dihe-in -76.56, 62.39 APE8-rot-na 28.45 APE67-dihe-in -70.14, -7.98 -53.04, -47.05 APE12-dist-na 17.5229 APE11-dist-na 18.8636 APE10-dist-na 13.8097 APE9-dist-out 8.4939 None None None XRAY 1.33 0.203 0.247 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 7kxm TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7KXPA Q06187 389 659 659.0 X9V:701 Type1 Inactive DFGin 6.6297 13.9869 BLBplus -119.7, 149.25 58.77, 30.75 -61.21, 130.4 38.19, 97.75 88.64, -21.79 out-out out 14.8008 Saltbr-out 15.3308 HRD-in -76.62, -57.43 86.07, -11.6 out-out-out SNCooo out-out ActLoopNT-out 7.9946 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.88, 2.42 APE9-dihe-in -67.56, 139.77 APE8-dihe-in -78.6, 62.9 APE8-rot-na 31.66 APE67-dihe-in -75.97, -4.4 -55.17, -43.17 APE12-dist-na 17.8339 APE11-dist-na 19.0914 APE10-dist-na 14.0948 APE9-dist-out 8.693 None None None XRAY 1.83 0.177 0.215 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 7kxp TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 3PIXA Q06187 391 658 659.0 027:1 Type1 Inactive DFGin 5.3666 15.249 BLBplus -130.02, -152.34 55.93, 45.93 -136.81, 147.54 66.75, 93.53 55.33, -135.04 out-out out 12.0196 Saltbr-out 13.9583 HRD-in -74.08, -51.7 83.0, -20.73 out-out-out SNCooo out-out ActLoopNT-out 11.5369 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -88.13, 91.42 APE9-dihe-in -86.77, 138.09 APE8-dihe-in -74.57, 63.36 APE8-rot-na 25.87 APE67-dihe-in -73.26, -10.96 -50.46, -44.46 APE12-dist-na 16.7616 APE11-dist-na 19.9367 APE10-dist-na 18.4933 APE9-dist-out 8.2339 None None None XRAY 1.85 0.229 0.266 A 274.0 268.0 0 29 29 0 [[402, 653]] 1.0 3pix TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5J87A Q06187 396 658 659.0 N42:701 Type1 Inactive DFGin 6.3334 13.6498 BLBplus -123.42, 149.38 64.52, 28.82 -63.82, 130.7 36.78, 95.48 84.02, -10.49 out-out out 16.4042 Saltbr-out 14.4358 HRD-in -71.23, -53.8 79.96, -6.34 out-out-out SNCooo out-out ActLoopNT-out 7.667 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.16, -6.26 APE9-dihe-in -66.24, 144.47 APE8-dihe-in -83.41, 68.08 APE8-rot-na 29.78 APE67-dihe-in -68.04, -20.26 -62.31, -40.48 APE12-dist-na 17.3078 APE11-dist-na 18.9168 APE10-dist-na 13.8038 APE9-dist-out 8.4943 None None None XRAY 1.59 0.22 0.248 A 274.0 263.0 0 29 29 0 [[402, 653]] 1.0 5j87 TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5J87B Q06187 385 658 659.0 N42:701 Type1 Inactive DFGin 6.3073 13.5658 BLBplus -116.27, 147.16 64.48, 33.44 -63.72, 133.38 37.03, 94.6 70.54, 9.28 out-out out 16.6033 Saltbr-out 18.4992 HRD-in -71.08, -49.77 81.97, -10.6 out-out-out SNCooo out-out ActLoopNT-out 7.4852 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.87, 1.28 APE9-dihe-in -69.91, 147.55 APE8-dihe-in -80.31, 62.9 APE8-rot-na 20.94 APE67-dihe-in -70.97, -11.78 -58.07, -42.19 APE12-dist-na 17.5467 APE11-dist-na 18.8381 APE10-dist-na 14.0075 APE9-dist-out 8.5454 None None None XRAY 1.59 0.22 0.248 B 274.0 274.0 0 29 29 0 [[402, 653]] 1.0 5j87 TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5J87C Q06187 396 656 659.0 N42:701 Type1 Inactive DFGin 6.4048 13.5465 BLBplus -126.4, 157.43 65.83, 26.36 -68.75, 129.53 36.85, 83.12 64.87, 13.16 out-out out 14.9009 Saltbr-out 13.3145 HRD-in -69.99, -46.79 81.42, -9.8 out-out-out SNCooo out-out ActLoopNT-out 7.7099 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -109.62, 3.15 APE9-dihe-in -83.23, 132.48 APE8-dihe-in -75.66, 67.36 APE8-rot-na 16.98 APE67-dihe-in -69.08, -9.78 -57.68, -42.7 APE12-dist-na 17.6117 APE11-dist-na 18.9693 APE10-dist-na 13.9416 APE9-dist-out 8.3626 None None None XRAY 1.59 0.22 0.248 C 274.0 261.0 0 29 29 0 [[402, 653]] 1.0 5j87 TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5J87D Q06187 396 658 659.0 N42:701 Type1 Inactive DFGin 6.0296 14.2516 BLBplus -123.89, 170.41 74.82, 20.6 -71.67, 132.66 44.67, 90.2 89.11, -16.56 out-out out 16.2582 Saltbr-out 13.8793 HRD-in -99.01, -51.17 80.74, -9.08 out-out-out SNCooo out-out ActLoopNT-out 7.7879 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -126.19, -24.51 APE9-dihe-in -55.82, 128.59 APE8-dihe-in -67.92, 50.84 APE8-rot-na 21.56 APE67-dihe-in -78.89, -3.66 -45.75, -40.96 APE12-dist-na 17.2101 APE11-dist-na 18.9448 APE10-dist-na 13.5524 APE9-dist-out 8.5228 None None None XRAY 1.59 0.22 0.248 D 274.0 263.0 0 29 29 0 [[402, 653]] 1.0 5j87 TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6TFPA Q06187 393 658 659.0 N6Z:60702 Type1 Inactive DFGin 6.327 13.6595 BLBplus -118.44, 153.59 59.47, 29.92 -60.13, 129.75 36.78, 92.22 75.92, -11.76 out-out out 16.0171 Saltbr-out 16.6878 HRD-in -72.75, -58.51 83.1, -15.47 out-out-out SNCooo out-out ActLoopNT-out 7.6876 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.23, -2.15 APE9-dihe-in -63.02, 134.87 APE8-dihe-in -76.81, 63.19 APE8-rot-na 30.22 APE67-dihe-in -65.58, -11.41 -51.73, -47.33 APE12-dist-na 17.5277 APE11-dist-na 19.1405 APE10-dist-na 13.9471 APE9-dist-out 8.6424 None None None XRAY 2.0 0.187 0.204 A 276.0 266.0 0 29 29 0 [[402, 653]] 1.0 6tfp TYR_BTK_HUMAN TYR 6.5e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6TFPB Q06187 385 658 659.0 N6Z:60701 Type1 Inactive DFGin 6.1662 13.6678 BLBplus -118.0, 154.73 59.63, 30.17 -62.33, 132.22 37.59, 92.25 73.87, -0.71 out-out out 15.8408 Saltbr-out 17.7523 HRD-in -74.6, -59.47 81.53, -13.42 out-out-out SNCooo out-out ActLoopNT-out 7.53 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.86, -1.96 APE9-dihe-in -63.72, 134.46 APE8-dihe-in -76.89, 63.04 APE8-rot-na 31.07 APE67-dihe-in -66.15, -10.82 -52.17, -45.8 APE12-dist-na 17.7066 APE11-dist-na 19.235 APE10-dist-na 14.024 APE9-dist-out 8.8483 None None None XRAY 2.0 0.187 0.204 B 276.0 274.0 0 29 29 0 [[402, 653]] 1.0 6tfp TYR_BTK_HUMAN TYR 6.5e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6TFPC Q06187 394 657 659.0 N6Z:60702 Type1 Inactive DFGin 6.2006 13.7005 BLBplus -117.6, 153.94 59.07, 30.48 -61.34, 130.98 37.37, 83.09 74.02, -4.64 out-none out 16.1105 Saltbr-none 999.0 HRD-in -74.15, -57.57 80.85, -14.64 none-out-out SNCnoo out-out ActLoopNT-out 7.6494 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -105.77, -3.85 APE9-dihe-in -63.13, 135.07 APE8-dihe-in -77.67, 62.93 APE8-rot-na 30.6 APE67-dihe-in -66.7, -11.3 -51.86, -46.0 APE12-dist-na 17.5254 APE11-dist-na 19.1212 APE10-dist-na 13.9265 APE9-dist-out 8.6334 None None None XRAY 2.0 0.187 0.204 C 276.0 264.0 0 29 29 0 [[402, 653]] 1.0 6tfp TYR_BTK_HUMAN TYR 6.5e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6TFPD Q06187 392 657 659.0 N6Z:60701 Type1 Inactive DFGin 6.4438 13.6643 BLBplus -117.89, 154.44 59.45, 29.6 -61.22, 132.28 38.37, 92.33 75.2, -12.98 out-none out 15.8644 Saltbr-none 999.0 HRD-in -73.87, -57.83 81.15, -12.26 none-out-out SNCnoo out-out ActLoopNT-out 7.4869 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.06, -4.9 APE9-dihe-in -61.09, 135.98 APE8-dihe-in -77.04, 64.98 APE8-rot-na 31.67 APE67-dihe-in -68.88, -9.49 -51.15, -46.71 APE12-dist-na 17.6695 APE11-dist-na 19.1253 APE10-dist-na 13.9019 APE9-dist-out 8.6191 None None None XRAY 2.0 0.187 0.204 D 276.0 266.0 0 29 29 0 [[402, 653]] 1.0 6tfp TYR_BTK_HUMAN TYR 6.5e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6TFPE Q06187 394 657 659.0 N6Z:60701 Type1 Inactive DFGin 6.3443 13.7202 BLBplus -119.29, 154.3 57.93, 31.21 -61.51, 131.73 36.79, 91.21 74.06, -7.73 out-none out 16.0071 Saltbr-none 999.0 HRD-in -74.54, -59.23 82.44, -13.81 none-out-out SNCnoo out-out ActLoopNT-out 7.529 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.89, -3.77 APE9-dihe-in -61.76, 133.54 APE8-dihe-in -77.43, 62.05 APE8-rot-na 31.22 APE67-dihe-in -64.03, -12.65 -49.68, -49.32 APE12-dist-na 17.6877 APE11-dist-na 19.1528 APE10-dist-na 13.9211 APE9-dist-out 8.8674 None None None XRAY 2.0 0.187 0.204 E 276.0 264.0 0 29 29 0 [[402, 653]] 1.0 6tfp TYR_BTK_HUMAN TYR 6.5e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5P9FA Q06187 394 659 659.0 2VL:701 Type1 Inactive DFGin 6.6211 13.7553 BLBplus -119.02, 151.22 61.15, 24.35 -53.19, 127.83 42.31, 92.54 85.51, -16.73 out-out out 14.4003 Saltbr-out 15.0261 HRD-in -75.39, -58.81 80.41, -9.12 out-out-out SNCooo out-out ActLoopNT-out 8.005 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.51, 4.62 APE9-dihe-in -72.87, 137.83 APE8-dihe-in -76.24, 65.65 APE8-rot-na 33.67 APE67-dihe-in -72.92, -8.6 -57.83, -44.5 APE12-dist-na 17.3063 APE11-dist-na 18.6164 APE10-dist-na 13.6802 APE9-dist-out 8.3054 None None None XRAY 1.71 0.15 0.223 A 279.0 266.0 0 29 29 0 [[402, 653]] 1.0 5p9f TYR_BTK_HUMAN TYR 6.7e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5P9GA Q06187 394 658 659.0 7G6:701 Type1 Inactive DFGin 6.4719 13.8004 BLBplus -121.54, 153.43 59.66, 31.06 -64.75, 135.12 38.33, 95.17 81.68, -18.33 out-out out 14.5727 Saltbr-out 14.953 HRD-in -71.17, -55.56 80.66, -15.66 out-out-out SNCooo out-out ActLoopNT-out 7.9688 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.63, -5.03 APE9-dihe-in -65.5, 140.21 APE8-dihe-in -77.62, 62.47 APE8-rot-na 26.45 APE67-dihe-in -75.18, -9.51 -50.31, -43.78 APE12-dist-na 17.3031 APE11-dist-na 18.8532 APE10-dist-na 13.8123 APE9-dist-out 8.5895 None None None XRAY 1.75 0.179 0.213 A 279.0 265.0 0 29 29 0 [[402, 653]] 1.0 5p9g TYR_BTK_HUMAN TYR 6.7e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5P9HA Q06187 395 658 659.0 7G7:701 Type1 Inactive DFGin 6.3198 13.8105 BLBplus -118.55, 159.68 43.16, 40.92 -70.17, 128.34 37.0, 93.74 78.75, -7.22 out-none out 15.1498 Saltbr-none 999.0 HRD-in -82.15, -48.19 78.47, -9.65 none-out-out SNCnoo out-out ActLoopNT-out 8.2168 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.58, -14.37 APE9-dihe-in -56.69, 135.42 APE8-dihe-in -75.24, 63.1 APE8-rot-na 30.9 APE67-dihe-in -69.63, -24.38 -50.99, -52.47 APE12-dist-na 17.4616 APE11-dist-na 18.8205 APE10-dist-na 13.5339 APE9-dist-out 8.6019 None None None XRAY 1.95 0.269 0.313 A 279.0 264.0 0 29 29 0 [[402, 653]] 1.0 5p9h TYR_BTK_HUMAN TYR 6.7e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5P9KA Q06187 389 659 659.0 7G8:701 Type1 Inactive DFGin 5.9055 13.8153 BLBplus -123.17, 157.03 60.3, 30.92 -61.09, 126.3 32.87, 95.3 80.22, -7.56 out-out out 14.7026 Saltbr-out 14.3026 HRD-in -69.5, -51.33 77.8, -10.26 out-out-out SNCooo out-out ActLoopNT-out 8.2343 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -124.98, 19.37 APE9-dihe-in -73.18, 146.14 APE8-dihe-in -78.75, 62.96 APE8-rot-na 28.96 APE67-dihe-in -72.55, -8.33 -49.89, -44.34 APE12-dist-na 16.7887 APE11-dist-na 19.0498 APE10-dist-na 14.4236 APE9-dist-out 8.789 None None None XRAY 1.28 0.18 0.195 A 279.0 271.0 0 29 29 0 [[402, 653]] 1.0 5p9k TYR_BTK_HUMAN TYR 6.7e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5P9LA Q06187 392 657 659.0 7G9:701 Type1 Inactive DFGin 6.0865 13.7982 BLBplus -122.11, 164.8 58.63, 30.82 -60.7, 123.17 37.36, 89.52 81.48, -10.88 out-none out 14.5981 Saltbr-none 999.0 HRD-in -66.82, -52.81 82.97, -17.59 none-out-out SNCnoo out-out ActLoopNT-out 8.2767 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 121.97 APE9-dihe-in -75.24, 140.2 APE8-dihe-in -82.91, 65.05 APE8-rot-na 32.95 APE67-dihe-in -69.39, -8.36 -46.7, -47.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.3777 APE9-dist-out 8.43 None None None XRAY 1.25 0.266 0.28 A 279.0 252.0 14 29 19 10 [[402, 653]] 1.0 5p9l TYR_BTK_HUMAN TYR 6.7e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6AUAA Q06187 394 656 659.0 BXJ:60704 Type1 Inactive DFGin 6.0347 13.8462 BLBplus -113.46, 143.81 62.23, 31.25 -55.6, 131.48 39.5, 93.47 79.78, -7.69 out-out out 15.9647 Saltbr-out 16.1685 HRD-in -76.15, -57.98 83.66, -10.89 out-out-out SNCooo out-out ActLoopNT-out 7.689 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -108.59, -5.57 APE9-dihe-in -65.02, 138.16 APE8-dihe-in -78.22, 60.51 APE8-rot-na 28.78 APE67-dihe-in -70.24, -9.7 -52.84, -43.32 APE12-dist-na 17.8975 APE11-dist-na 19.5071 APE10-dist-na 14.1964 APE9-dist-out 8.6725 None None None XRAY 1.66 0.158 0.185 A 265.0 263.0 0 29 29 0 [[402, 653]] 1.0 6aua TYR_BTK_HUMAN TYR 2.5e-92 314.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6NZMA Q06187 395 659 659.0 L9S:701 Type1 Inactive DFGin 6.1954 13.4061 BLBplus -127.43, 159.91 61.39, 26.55 -69.03, 132.98 44.91, 93.72 80.46, -12.65 out-none out 14.3945 Saltbr-none 999.0 HRD-in -68.73, -54.84 83.57, -10.4 none-out-out SNCnoo out-out ActLoopNT-out 8.1073 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -121.71, 16.48 APE9-dihe-in -71.64, 143.15 APE8-dihe-in -80.68, 63.75 APE8-rot-na 25.92 APE67-dihe-in -79.55, -7.2 -50.65, -39.49 APE12-dist-na 17.0531 APE11-dist-na 19.2307 APE10-dist-na 14.512 APE9-dist-out 8.7338 None None None XRAY 1.72 0.179 0.248 A 280.0 263.0 2 29 29 0 [[402, 653]] 1.0 6nzm TYR_BTK_HUMAN TYR 6.8e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6NZMD Q06187 395 659 659.0 L9S:701 Type1 Inactive DFGin 6.4985 13.2753 BLBplus -122.27, 161.21 59.21, 28.98 -64.38, 134.47 41.01, 97.39 85.68, -23.76 out-none out 14.1566 Saltbr-none 999.0 HRD-in -71.79, -59.45 78.27, -11.98 none-out-out SNCnoo out-out ActLoopNT-out 8.112 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -112.69, 14.7 APE9-dihe-in -72.11, 142.63 APE8-dihe-in -71.57, 65.61 APE8-rot-na 26.12 APE67-dihe-in -72.16, -8.93 -55.34, -48.1 APE12-dist-na 17.0086 APE11-dist-na 19.3322 APE10-dist-na 14.4792 APE9-dist-out 8.5308 None None None XRAY 1.72 0.179 0.248 D 280.0 264.0 1 29 29 0 [[402, 653]] 1.0 6nzm TYR_BTK_HUMAN TYR 6.8e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5BQ0A Q06187 389 659 659.0 4US:701 Type1 Inactive DFGin 5.711 14.0136 BLBplus -117.6, 165.11 53.91, 38.74 -59.87, 121.33 28.42, 97.88 75.49, -0.27 out-out out 14.9455 Saltbr-out 16.0917 HRD-in -77.3, -50.19 77.41, -8.91 out-out-out SNCooo out-out ActLoopNT-out 8.3116 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 12.37 APE9-dihe-in -68.79, 138.87 APE8-dihe-in -78.23, 64.02 APE8-rot-na 30.42 APE67-dihe-in -72.74, -6.77 -51.3, -44.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.7299 APE9-dist-out 8.6904 None None None XRAY 1.57 0.19 0.219 A 283.0 265.0 6 29 23 6 [[402, 653]] 1.0 5bq0 TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 8FLHA Q06187 392 658 659.0 Y8H:703 Type1 Inactive DFGin 7.0006 13.7342 BLBplus -127.47, 151.88 58.58, 32.99 -67.63, 130.52 34.3, 97.77 79.25, -6.93 out-out out 14.6904 Saltbr-out 14.7005 HRD-in -69.17, -50.0 76.15, -10.29 out-out-out SNCooo out-out ActLoopNT-out 8.0494 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.61, 11.99 APE9-dihe-in -73.04, 144.49 APE8-dihe-in -77.86, 68.14 APE8-rot-na 28.99 APE67-dihe-in -72.4, -8.49 -56.82, -41.52 APE12-dist-na 16.7703 APE11-dist-na 18.9554 APE10-dist-na 13.9252 APE9-dist-out 8.7506 None None None XRAY 1.55 0.197 0.229 A 283.0 266.0 1 29 28 1 [[402, 653]] 1.0 8flh TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 8FLVA Q06187 393 659 659.0 ZB9:701 Type1 Inactive DFGin 5.669 14.2437 BLBplus -122.23, 158.44 56.54, 34.26 -67.16, 128.51 35.91, 92.8 76.32, -0.09 out-out out 14.9439 Saltbr-out 15.2811 HRD-in -72.16, -49.95 77.25, -10.81 out-out-out SNCooo out-out ActLoopNT-out 8.151 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.66, 2.02 APE9-dihe-in -69.36, 139.1 APE8-dihe-in -76.14, 67.4 APE8-rot-na 26.98 APE67-dihe-in -72.71, -7.5 -54.62, -43.72 APE12-dist-na 16.6787 APE11-dist-na 18.3869 APE10-dist-na 13.4155 APE9-dist-out 8.5691 None None None XRAY 1.3 0.195 0.218 A 283.0 267.0 0 29 29 0 [[402, 653]] 1.0 8flv TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 8TU3A Q06187 394 659 659.0 UEO:701 Type1 Inactive DFGin 5.7847 13.6177 BLBplus -118.94, 154.76 59.04, 31.29 -57.96, 130.06 31.96, 96.16 75.95, -6.59 out-out out 14.696 Saltbr-out 15.5429 HRD-in -75.98, -52.49 80.0, -9.2 out-out-out SNCooo out-out ActLoopNT-out 8.3403 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 12.55 APE9-dihe-in -80.8, 143.02 APE8-dihe-in -72.08, 65.2 APE8-rot-na 27.74 APE67-dihe-in -71.72, -7.13 -52.35, -43.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.9327 APE9-dist-out 8.3609 None None None XRAY 1.7 0.23 0.277 A 283.0 256.0 10 29 19 10 [[402, 653]] 1.0 8tu3 TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 8TU4A Q06187 394 659 659.0 V72:701 Type1 Inactive DFGin 5.7649 13.7108 BLBplus -117.24, 150.52 56.84, 36.3 -61.24, 131.28 29.95, 97.51 78.97, -10.08 out-out out 14.6134 Saltbr-out 14.8418 HRD-in -73.78, -51.72 77.75, -7.8 out-out-out SNCooo out-out ActLoopNT-out 8.2634 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 15.07 APE9-dihe-in -78.81, 146.79 APE8-dihe-in -82.47, 66.86 APE8-rot-na 32.41 APE67-dihe-in -75.78, -8.88 -52.09, -40.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.931 APE9-dist-out 8.69 None None None XRAY 1.6 0.222 0.259 A 283.0 256.0 10 29 19 10 [[402, 653]] 1.0 8tu4 TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 8TU5A Q06187 395 657 659.0 V7I:701 Type1 Inactive DFGin 5.6233 13.5299 BLBplus -125.91, 165.44 53.12, 36.0 -67.69, 121.08 34.15, 91.54 83.04, -3.54 out-none out 14.8728 Saltbr-none 999.0 HRD-in -74.47, -48.63 79.73, -8.49 none-out-out SNCnoo out-out ActLoopNT-out 8.1081 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.82 APE8-dihe-in -71.81, 67.92 APE8-rot-na 29.27 APE67-dihe-in -66.51, -10.87 -61.85, -41.92 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.6497 None None None XRAY 2.1 0.259 0.272 A 283.0 256.0 7 29 22 7 [[402, 653]] 1.0 8tu5 TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 4Z3VA Q06187 389 659 659.0 4L6:705 Type1 Inactive DFGin 6.4376 13.3172 BLBplus -121.73, 164.54 60.71, 27.14 -64.95, 131.66 31.2, 100.94 74.09, -7.1 out-out out 14.3362 Saltbr-out 14.6407 HRD-in -70.4, -49.08 77.3, -11.43 out-out-out SNCooo out-out ActLoopNT-out 8.1113 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -114.32, 5.17 APE9-dihe-in -67.18, 142.05 APE8-dihe-in -78.94, 63.22 APE8-rot-na 30.53 APE67-dihe-in -72.22, -6.74 -50.76, -45.21 APE12-dist-na 17.2803 APE11-dist-na 18.9098 APE10-dist-na 14.1045 APE9-dist-out 8.942 None None None XRAY 1.6 0.166 0.198 A 283.0 271.0 0 29 29 0 [[402, 653]] 1.0 4z3v TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7N5OA Q06187 389 658 659.0 0BQ:703 Type1 Inactive DFGin 5.8074 13.9825 BLBplus -123.29, 163.38 59.79, 31.01 -63.34, 125.86 32.98, 94.63 79.65, -4.58 out-out out 14.8608 Saltbr-out 15.1937 HRD-in -72.05, -49.82 80.66, -12.55 out-out-out SNCooo out-out ActLoopNT-out 8.2065 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -120.67, 12.19 APE9-dihe-in -72.74, 144.88 APE8-dihe-in -78.42, 64.27 APE8-rot-na 27.8 APE67-dihe-in -73.8, -6.15 -52.47, -44.34 APE12-dist-na 17.0828 APE11-dist-na 18.9824 APE10-dist-na 14.172 APE9-dist-out 8.9063 None None None XRAY 1.25 0.179 0.196 A 283.0 270.0 0 29 29 0 [[402, 653]] 1.0 7n5o TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7N5RA Q06187 389 658 659.0 0UW:704 Type1 Inactive DFGin 5.8484 14.0833 BLBplus -120.44, 160.96 61.17, 29.05 -63.79, 128.58 33.86, 93.89 78.98, -6.22 out-out out 14.8311 Saltbr-out 14.6152 HRD-in -71.43, -50.09 81.43, -11.02 out-out-out SNCooo out-out ActLoopNT-out 8.2236 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -117.5, 12.88 APE9-dihe-in -70.22, 144.62 APE8-dihe-in -82.33, 64.59 APE8-rot-na 28.16 APE67-dihe-in -75.2, -6.05 -52.81, -44.49 APE12-dist-na 17.1763 APE11-dist-na 19.0205 APE10-dist-na 14.2056 APE9-dist-out 8.9693 None None None XRAY 1.55 0.172 0.195 A 283.0 270.0 0 29 29 0 [[402, 653]] 1.0 7n5r TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7N5XA Q06187 389 658 659.0 0GW:705 Type1 Inactive DFGin 5.8249 14.1413 BLBplus -122.98, 162.6 61.95, 30.97 -64.19, 123.83 32.93, 94.28 81.06, -6.49 out-out out 14.9169 Saltbr-out 14.9652 HRD-in -71.63, -54.05 81.79, -7.95 out-out-out SNCooo out-out ActLoopNT-out 8.1748 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -119.58, 14.9 APE9-dihe-in -74.21, 146.6 APE8-dihe-in -81.36, 66.06 APE8-rot-na 31.26 APE67-dihe-in -73.27, -8.48 -54.05, -44.57 APE12-dist-na 17.1686 APE11-dist-na 19.0472 APE10-dist-na 14.1696 APE9-dist-out 8.8049 None None None XRAY 1.6 0.167 0.188 A 283.0 269.0 1 29 28 1 [[402, 653]] 1.0 7n5x TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7N5YA Q06187 389 658 659.0 0CI:702 Type1 Inactive DFGin 5.8503 13.9269 BLBplus -119.73, 159.64 61.05, 31.21 -60.16, 124.56 30.4, 95.67 76.7, -6.8 out-out out 14.8465 Saltbr-out 14.0387 HRD-in -69.54, -53.84 78.09, -6.42 out-out-out SNCooo out-out ActLoopNT-out 8.2102 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -118.04, 12.35 APE9-dihe-in -69.71, 142.6 APE8-dihe-in -78.04, 68.29 APE8-rot-na 29.87 APE67-dihe-in -74.58, -10.82 -57.15, -42.34 APE12-dist-na 17.1239 APE11-dist-na 19.0224 APE10-dist-na 14.2529 APE9-dist-out 8.892 None None None XRAY 1.85 0.165 0.202 A 283.0 270.0 0 29 29 0 [[402, 653]] 1.0 7n5y TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6BIKA Q06187 395 657 659.0 DTJ:60703 Type1 Inactive DFGin 6.3841 14.0002 BLBplus -119.8, 152.4 60.52, 28.21 -56.87, 131.18 36.5, 96.72 81.2, -12.47 out-none out 16.6842 Saltbr-none 999.0 HRD-in -74.16, -57.25 88.25, -17.53 none-out-out SNCnoo out-out ActLoopNT-out 7.6051 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.83, -2.2 APE9-dihe-in -67.83, 138.28 APE8-dihe-in -73.88, 59.52 APE8-rot-na 27.43 APE67-dihe-in -69.41, -12.39 -52.91, -44.34 APE12-dist-na 17.3939 APE11-dist-na 18.9683 APE10-dist-na 13.8335 APE9-dist-out 8.5211 None None OCS481 XRAY 1.901 0.164 0.222 A 287.0 263.0 0 29 29 0 [[402, 653]] 1.0 6bik TYR_BTK_HUMAN TYR 7.5e-93 316.5 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6BKEA Q06187 395 657 659.0 DVJ:60704 Type1 Inactive DFGin 6.4876 13.9383 BLBplus -126.32, 153.83 60.67, 32.8 -70.23, 116.75 39.9, 95.03 97.51, -8.65 out-none out 16.4001 Saltbr-none 999.0 HRD-in -77.9, -59.26 85.69, -8.86 none-out-out SNCnoo out-out ActLoopNT-out 7.605 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.43, -4.68 APE9-dihe-in -63.91, 139.08 APE8-dihe-in -79.1, 67.74 APE8-rot-na 29.94 APE67-dihe-in -71.93, -10.38 -60.35, -42.97 APE12-dist-na 17.3132 APE11-dist-na 18.7054 APE10-dist-na 13.6717 APE9-dist-out 8.3796 None None OCS481 XRAY 1.95 0.195 0.21 A 287.0 263.0 0 29 29 0 [[402, 653]] 1.0 6bke TYR_BTK_HUMAN TYR 7.5e-93 316.5 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6BKHA Q06187 396 657 659.0 DVD:60705 Type1 Inactive DFGin 6.1988 13.9213 BLBplus -120.76, 152.75 61.05, 28.99 -60.38, 133.58 37.31, 96.56 79.08, -14.5 out-none out 16.3231 Saltbr-none 999.0 HRD-in -71.21, -59.82 85.99, -15.66 none-out-out SNCnoo out-out ActLoopNT-out 7.4761 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -104.4, -2.91 APE9-dihe-in -63.79, 139.55 APE8-dihe-in -76.66, 61.14 APE8-rot-na 31.95 APE67-dihe-in -72.41, -9.9 -54.11, -43.03 APE12-dist-na 17.4099 APE11-dist-na 18.7351 APE10-dist-na 13.6543 APE9-dist-out 8.5138 None None OCS481 XRAY 1.792 0.155 0.201 A 287.0 262.0 0 29 29 0 [[402, 653]] 1.0 6bkh TYR_BTK_HUMAN TYR 7.5e-93 316.5 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6BLNA Q06187 395 657 659.0 DY4:60704 Type1 Inactive DFGin 6.5839 13.9111 BLBplus -124.8, 153.54 63.35, 26.73 -64.52, 129.72 38.37, 96.67 86.35, -14.36 out-none out 16.3978 Saltbr-none 999.0 HRD-in -71.3, -59.79 85.0, -16.09 none-out-out SNCnoo out-out ActLoopNT-out 7.6162 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.97, -4.42 APE9-dihe-in -63.01, 141.51 APE8-dihe-in -78.86, 60.98 APE8-rot-na 31.85 APE67-dihe-in -70.4, -8.96 -53.74, -45.58 APE12-dist-na 17.3722 APE11-dist-na 18.7594 APE10-dist-na 13.7412 APE9-dist-out 8.4961 None None OCS481 XRAY 1.3 0.157 0.176 A 287.0 263.0 0 29 29 0 [[402, 653]] 1.0 6bln TYR_BTK_HUMAN TYR 7.5e-93 316.5 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6XE4A Q06187 395 657 659.0 V1G:60701 Type1 Inactive DFGin 6.1943 13.6407 BLBplus -118.24, 147.72 59.06, 30.5 -55.62, 131.44 40.31, 93.31 84.57, -17.21 out-out out 16.4477 Saltbr-out 16.2729 HRD-in -71.74, -55.94 86.25, -14.57 out-out-out SNCooo out-out ActLoopNT-out 7.5294 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.94, -7.76 APE9-dihe-in -61.33, 140.85 APE8-dihe-in -79.95, 62.63 APE8-rot-na 31.88 APE67-dihe-in -68.74, -9.88 -56.03, -45.01 APE12-dist-na 17.4824 APE11-dist-na 18.9134 APE10-dist-na 13.7082 APE9-dist-out 8.5057 None None None XRAY 1.6 0.159 0.18 A 287.0 263.0 0 29 29 0 [[402, 653]] 1.0 6xe4 TYR_BTK_HUMAN TYR 7.5e-93 316.5 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6VXQA Q06187 392 658 659.0 RQS:702 Type1 Inactive DFGin 5.9063 13.6898 BLBplus -122.83, 157.58 57.26, 33.98 -59.89, 127.74 30.82, 94.77 79.05, -7.39 out-out out 14.3059 Saltbr-out 14.854 HRD-in -69.21, -50.72 77.9, -12.04 out-out-out SNCooo out-out ActLoopNT-out 8.1677 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -106.85, 10.15 APE9-dihe-in -68.94, 144.76 APE8-dihe-in -79.49, 60.01 APE8-rot-na 30.12 APE67-dihe-in -70.66, -9.2 -48.35, -45.21 APE12-dist-na 999.0 APE11-dist-na 18.1042 APE10-dist-na 13.7832 APE9-dist-out 8.6338 None None None XRAY 1.4 0.186 0.224 A 293.0 258.0 9 29 20 9 [[402, 653]] 1.0 6vxq TYR_BTK_HUMAN TYR 8e-93 316.4 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6W06A Q06187 393 659 659.0 S5M:1103 Type1 Inactive DFGin 6.3583 13.8219 BLBplus -123.71, 156.56 59.73, 31.74 -64.1, 135.24 36.24, 95.13 79.05, -18.5 out-out out 14.6291 Saltbr-out 15.2181 HRD-in -69.12, -54.37 83.0, -13.71 out-out-out SNCooo out-out ActLoopNT-out 7.9362 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -108.14, 1.34 APE9-dihe-in -68.88, 143.25 APE8-dihe-in -80.0, 64.87 APE8-rot-na 30.09 APE67-dihe-in -71.63, -9.29 -52.57, -44.76 APE12-dist-na 17.3783 APE11-dist-na 19.112 APE10-dist-na 14.0739 APE9-dist-out 8.6361 None None None XRAY 1.55 0.197 0.225 A 293.0 267.0 0 29 29 0 [[402, 653]] 1.0 6w06 TYR_BTK_HUMAN TYR 8e-93 316.4 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6W07A Q06187 393 658 659.0 S9A:901 Type1 Inactive DFGin 5.8952 13.8117 BLBplus -121.55, 148.3 60.83, 28.42 -56.86, 131.76 40.16, 94.44 81.08, -19.73 out-out out 14.6151 Saltbr-out 15.5547 HRD-in -64.74, -55.07 81.47, -10.71 out-out-out SNCooo out-out ActLoopNT-out 7.9129 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -97.59, 1.54 APE9-dihe-in -71.47, 144.5 APE8-dihe-in -78.84, 63.09 APE8-rot-na 27.44 APE67-dihe-in -79.6, -3.04 -59.76, -38.2 APE12-dist-na 17.4025 APE11-dist-na 18.9013 APE10-dist-na 13.7933 APE9-dist-out 8.7012 None None None XRAY 1.51 0.231 0.267 A 293.0 264.0 2 29 29 0 [[402, 653]] 1.0 6w07 TYR_BTK_HUMAN TYR 8e-93 316.4 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 8FLGA Q06187 395 659 659.0 Y8C:702 Type1 Inactive DFGin 5.8019 14.0811 BLBplus -120.07, 171.21 57.33, 28.78 -64.54, 135.98 37.48, 93.3 76.87, -5.06 out-out out 15.1689 Saltbr-out 14.6997 HRD-in -72.29, -50.51 73.76, -11.04 out-out-out SNCooo out-out ActLoopNT-out 8.2217 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.78, 12.49 APE9-dihe-in -73.43, 144.93 APE8-dihe-in -74.0, 67.63 APE8-rot-na 352.82 APE67-dihe-in -69.94, -9.06 -58.47, -43.92 APE12-dist-na 16.651 APE11-dist-na 18.7009 APE10-dist-na 13.8353 APE9-dist-out 8.7046 None None None XRAY 2.2 0.198 0.254 A 293.0 261.0 4 29 29 0 [[402, 653]] 1.0 8flg TYR_BTK_HUMAN TYR 8e-93 316.4 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 4OT5A Q06187 396 658 659.0 481:701 Type1 Inactive DFGin 6.798 13.802 BLBplus -124.36, 153.13 64.4, 22.83 -60.17, 134.59 35.61, 95.76 78.16, -11.12 out-out out 14.3644 Saltbr-out 14.7935 HRD-in -77.95, -53.68 73.97, -6.47 out-out-out SNCooo out-out ActLoopNT-out 7.7941 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.42, 0.06 APE9-dihe-in -66.16, 143.44 APE8-dihe-in -81.04, 65.47 APE8-rot-na 30.95 APE67-dihe-in -72.59, -7.35 -55.28, -46.28 APE12-dist-na 17.5583 APE11-dist-na 19.1681 APE10-dist-na 14.0056 APE9-dist-out 8.3931 M489A,R492A,E624A,K625A None None XRAY 1.55 0.143 0.194 A 283.0 263.0 0 29 29 0 [[402, 653]] 1.0 4ot5 TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 4OT6A Q06187 394 658 659.0 2V1:701 Type1 Inactive DFGin 6.4725 13.7394 BLBplus -120.83, 155.02 54.77, 30.09 -59.69, 128.73 35.37, 98.86 78.94, -1.38 out-out out 15.5686 Saltbr-out 16.2187 HRD-in -74.99, -53.47 75.85, -9.95 out-out-out SNCooo out-out ActLoopNT-out 7.9105 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -123.76, 12.12 APE9-dihe-in -69.26, 136.59 APE8-dihe-in -72.58, 60.99 APE8-rot-na 26.45 APE67-dihe-in -70.3, -14.09 -50.44, -42.82 APE12-dist-na 17.4004 APE11-dist-na 19.2434 APE10-dist-na 14.4215 APE9-dist-out 8.5641 M489A,R492A,E624A,K625A None None XRAY 2.05 0.219 0.278 A 283.0 265.0 0 29 29 0 [[402, 653]] 1.0 4ot6 TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 4OTQA Q06187 396 658 659.0 2V2:701 Type1 Inactive DFGin 6.6664 13.9201 BLBplus -120.48, 151.21 61.07, 26.68 -61.61, 135.39 39.54, 95.11 81.03, -13.62 out-out out 14.3287 Saltbr-out 14.647 HRD-in -78.07, -55.02 76.57, -9.58 out-out-out SNCooo out-out ActLoopNT-out 7.6891 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -114.08, -3.11 APE9-dihe-in -65.13, 140.69 APE8-dihe-in -79.51, 63.96 APE8-rot-na 32.39 APE67-dihe-in -73.32, -5.64 -54.47, -47.5 APE12-dist-na 17.5552 APE11-dist-na 19.0077 APE10-dist-na 13.8866 APE9-dist-out 8.2582 M489A,R492A,E624A,K625A None None XRAY 1.55 0.15 0.189 A 283.0 263.0 0 29 29 0 [[402, 653]] 1.0 4otq TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 4OTRA Q06187 396 658 659.0 2V3:701 Type1 Inactive DFGin 6.3496 13.7746 BLBplus -119.48, 149.94 64.46, 21.96 -55.92, 130.38 40.22, 95.71 83.39, -9.14 out-out out 15.6674 Saltbr-out 16.3264 HRD-in -80.64, -53.94 77.44, -10.65 out-out-out SNCooo out-out ActLoopNT-out 7.7294 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.0, 0.07 APE9-dihe-in -66.03, 138.84 APE8-dihe-in -74.94, 59.43 APE8-rot-na 28.29 APE67-dihe-in -69.85, -12.86 -50.01, -47.21 APE12-dist-na 17.2616 APE11-dist-na 18.998 APE10-dist-na 13.8966 APE9-dist-out 8.2156 M489A,R492A,E624A,K625A None None XRAY 1.95 0.183 0.229 A 283.0 263.0 0 29 29 0 [[402, 653]] 1.0 4otr TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 4RFYA Q06187 396 658 659.0 3OU:701 Type1 Inactive DFGin 6.511 13.8944 BLBplus -125.37, 155.11 59.5, 29.61 -67.87, 135.59 36.18, 99.4 80.78, -11.15 out-out out 14.3118 Saltbr-out 14.8285 HRD-in -73.99, -53.56 68.51, -7.57 out-out-out SNCooo out-out ActLoopNT-out 7.7675 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.93, 5.87 APE9-dihe-in -70.74, 143.29 APE8-dihe-in -76.69, 63.58 APE8-rot-na 29.89 APE67-dihe-in -76.8, -9.05 -56.47, -40.03 APE12-dist-na 17.3167 APE11-dist-na 19.0599 APE10-dist-na 14.088 APE9-dist-out 8.3327 M489A,R492A,E624A,K625A None None XRAY 1.7 0.184 0.219 A 283.0 263.0 0 29 29 0 [[402, 653]] 1.0 4rfy TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 4RFZA Q06187 396 658 659.0 3OV:701 Type1 Inactive DFGin 6.4738 13.8576 BLBplus -122.25, 154.4 62.29, 26.6 -61.76, 133.26 37.14, 97.18 80.17, -12.8 out-out out 14.3953 Saltbr-out 14.7442 HRD-in -73.89, -56.12 78.47, -8.51 out-out-out SNCooo out-out ActLoopNT-out 7.7796 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.55, -1.47 APE9-dihe-in -66.52, 144.01 APE8-dihe-in -81.41, 64.37 APE8-rot-na 27.37 APE67-dihe-in -73.77, -5.98 -53.3, -47.21 APE12-dist-na 17.3043 APE11-dist-na 19.0231 APE10-dist-na 14.0298 APE9-dist-out 8.2995 M489A,R492A,E624A,K625A None None XRAY 1.17 0.158 0.184 A 283.0 263.0 0 29 29 0 [[402, 653]] 1.0 4rfz TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 4RG0A Q06187 396 658 659.0 3P0:701 Type1 Inactive DFGin 6.0584 13.6825 BLBplus -111.63, 164.22 48.59, 22.66 -55.13, 122.3 47.16, 92.54 89.41, -9.26 out-out out 15.7607 Saltbr-out 16.5721 HRD-in -71.22, -55.66 80.23, -5.88 out-out-out SNCooo out-out ActLoopNT-out 7.5255 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.89, 2.41 APE9-dihe-in -69.3, 136.69 APE8-dihe-in -69.65, 64.41 APE8-rot-na 23.23 APE67-dihe-in -66.68, -7.08 -59.2, -53.75 APE12-dist-na 17.4366 APE11-dist-na 19.0132 APE10-dist-na 13.8407 APE9-dist-out 8.2177 M489A,R492A,E624A,K625A None None XRAY 2.5 0.203 0.282 A 283.0 263.0 0 29 29 0 [[402, 653]] 1.0 4rg0 TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6EP9A Q06187 396 658 659.0 BNB:701 Type1 Inactive DFGin 6.1666 13.9342 BLBplus -110.74, 150.79 56.23, 33.93 -61.07, 129.12 39.2, 95.59 79.19, -9.19 out-out out 14.7293 Saltbr-out 14.9123 HRD-in -77.75, -56.4 82.19, -12.26 out-out-out SNCooo out-out ActLoopNT-out 7.7856 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -106.21, 1.04 APE9-dihe-in -68.91, 137.58 APE8-dihe-in -72.36, 63.98 APE8-rot-na 26.41 APE67-dihe-in -73.5, -8.99 -57.91, -45.11 APE12-dist-na 17.7344 APE11-dist-na 19.2826 APE10-dist-na 14.1655 APE9-dist-out 8.3975 M489A,R492A,E624A,K625A None None XRAY 2.01 0.201 0.239 A 283.0 263.0 0 29 29 0 [[402, 653]] 1.0 6ep9 TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6HRPA Q06187 396 658 659.0 GMQ:701 Type1 Inactive DFGin 6.7785 13.8237 BLBplus -120.01, 154.93 63.87, 24.84 -63.8, 130.04 41.5, 95.52 80.52, -10.39 out-out out 14.4441 Saltbr-out 14.7807 HRD-in -76.75, -57.42 80.54, -8.58 out-out-out SNCooo out-out ActLoopNT-out 7.6882 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.6, -4.02 APE9-dihe-in -62.76, 144.95 APE8-dihe-in -81.63, 63.16 APE8-rot-na 29.31 APE67-dihe-in -73.11, -6.75 -53.02, -46.87 APE12-dist-na 17.3398 APE11-dist-na 18.8644 APE10-dist-na 13.8258 APE9-dist-out 8.2717 M489A,R492A,E624A,K625A None None XRAY 1.12 0.175 0.192 A 283.0 263.0 0 29 29 0 [[402, 653]] 1.0 6hrp TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6HRTA Q06187 396 658 659.0 GMW:701 Type1 Inactive DFGin 6.7678 13.6971 BLBplus -129.9, 157.16 58.03, 26.49 -64.79, 131.05 44.36, 88.77 85.95, -9.96 out-out out 14.4075 Saltbr-out 14.6019 HRD-in -77.59, -59.06 79.34, -5.85 out-out-out SNCooo out-out ActLoopNT-out 7.7112 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.93, -3.12 APE9-dihe-in -64.76, 141.34 APE8-dihe-in -77.14, 61.89 APE8-rot-na 34.59 APE67-dihe-in -73.94, -5.66 -51.96, -47.3 APE12-dist-na 17.5554 APE11-dist-na 19.0329 APE10-dist-na 14.0211 APE9-dist-out 8.3716 M489A,R492A,E624A,K625A None None XRAY 1.36 0.179 0.201 A 283.0 263.0 0 29 29 0 [[402, 653]] 1.0 6hrt TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 8GC8A Q06187 392 658 659.0 YXJ:701 Type1 Inactive DFGin 5.1834 15.1378 BLBplus -134.69, 175.7 58.6, 34.59 -69.33, 126.95 30.22, 92.4 68.12, 26.22 out-none out 10.2731 Saltbr-none 999.0 HRD-in -70.76, -51.81 78.81, -13.3 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -7.44 APE9-dihe-in -63.53, 136.38 APE8-dihe-in -74.86, 62.75 APE8-rot-na 28.86 APE67-dihe-in -70.09, -12.77 -52.21, -44.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.8226 APE9-dist-out 8.2583 L528W None None XRAY 1.75 0.197 0.223 A 270.0 253.0 14 29 15 14 [[402, 653]] 1.0 8gc8 TYR_BTK_HUMAN TYR 1e-91 312.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 8EJBA Q06187 389 658 659.0 WKC:701,PD:704 Type1,Allosteric Inactive DFGin 5.8635 14.131 BLBplus -124.35, 159.5 59.65, 31.06 -60.28, 129.86 32.43, 98.92 80.65, -9.58 out-out out 15.03 Saltbr-out 15.0205 HRD-in -75.99, -52.85 80.07, -7.93 out-out-out SNCooo out-out ActLoopNT-out 8.2475 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.26, -3.27 APE9-dihe-in -67.08, 143.23 APE8-dihe-in -76.66, 62.81 APE8-rot-na 33.31 APE67-dihe-in -73.82, -6.2 -53.78, -45.31 APE12-dist-na 17.3567 APE11-dist-na 18.9197 APE10-dist-na 13.9181 APE9-dist-out 8.7469 None None None XRAY 1.58 0.169 0.191 A 270.0 270.0 0 29 29 0 [[402, 653]] 1.0 8ejb TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6X3NA Q06187 392 659 659.0 ULV:701,5WE:702 Type1,Allosteric Inactive DFGin 4.8348 13.7977 BLBplus -128.18, -176.06 44.41, 34.78 -60.88, 111.95 32.8, 95.06 63.47, 33.77 out-out out 11.6687 Saltbr-out 11.8984 HRD-in -66.13, -43.52 63.4, 23.37 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -10.53 APE9-dihe-in -64.61, 137.44 APE8-dihe-in -75.97, 67.43 APE8-rot-na 33.99 APE67-dihe-in -69.55, -8.99 -53.26, -46.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.6731 APE9-dist-in 7.8964 None None None XRAY 1.95 0.215 0.242 A 271.0 254.0 14 29 15 14 [[402, 653]] 1.0 6x3n TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6BKWA Q06187 393 657 659.0 DXM:60704,FPZ:60705 Type1,Type1 Inactive DFGin 6.1862 13.6782 BLBplus -124.67, 165.61 61.44, 24.6 -62.17, 130.9 37.63, 93.68 82.92, -15.3 out-out out 15.9212 Saltbr-out 16.2424 HRD-in -73.62, -59.24 85.68, -13.49 out-out-out SNCooo out-out ActLoopNT-out 7.602 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -105.25, -3.91 APE9-dihe-in -65.93, 143.9 APE8-dihe-in -79.36, 62.05 APE8-rot-na 31.29 APE67-dihe-in -73.0, -8.66 -54.79, -43.17 APE12-dist-na 17.3041 APE11-dist-na 18.8657 APE10-dist-na 13.7968 APE9-dist-out 8.4671 None None OCS481 XRAY 1.499 0.164 0.19 A 287.0 265.0 0 29 29 0 [[402, 653]] 1.0 6bkw TYR_BTK_HUMAN TYR 7.5e-93 316.5 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6J6MA Q06187 393 659 659.0 BA0:701 Type1.5_Back Inactive DFGin 5.8121 13.0541 BLBplus -135.59, 169.19 55.61, 26.97 -64.95, 126.62 36.43, 91.43 74.18, -5.22 out-out out 14.6197 Saltbr-out 14.7674 HRD-in -71.43, -50.77 78.61, -11.37 out-out-out SNCooo out-out ActLoopNT-out 8.254 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -126.1, 23.72 APE9-dihe-in -77.33, 146.88 APE8-dihe-in -77.55, 62.03 APE8-rot-na 27.93 APE67-dihe-in -71.72, -9.7 -50.99, -43.68 APE12-dist-na 16.9263 APE11-dist-na 19.0797 APE10-dist-na 14.3364 APE9-dist-out 8.9377 None None None XRAY 1.25 0.158 0.164 A 269.0 267.0 0 29 29 0 [[402, 653]] 1.0 6j6m TYR_BTK_HUMAN TYR 5.9e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7R61A Q06187 390 659 659.0 2IJ:701 Type1.5_Back Inactive DFGin 6.1667 13.5106 BLBplus -130.09, 168.71 60.32, 26.86 -63.86, 125.8 36.94, 90.04 75.65, -5.37 out-out out 14.7698 Saltbr-out 14.6152 HRD-in -71.44, -55.62 86.29, -18.58 out-out-out SNCooo out-out ActLoopNT-out 8.1523 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -114.85, 23.78 APE9-dihe-in -75.91, 149.83 APE8-dihe-in -77.54, 62.5 APE8-rot-na 24.68 APE67-dihe-in -73.5, -9.4 -54.0, -41.43 APE12-dist-na 999.0 APE11-dist-na 18.7924 APE10-dist-na 14.2029 APE9-dist-out 8.6175 None None None XRAY 1.52 0.21 0.241 A 270.0 266.0 4 29 27 2 [[402, 653]] 1.0 7r61 TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6DI3A Q06187 393 659 659.0 GJA:701 Type1.5_Back Inactive DFGin 5.8529 13.4924 BLBplus -126.21, 173.61 50.38, 39.23 -74.31, 132.3 30.93, 92.98 76.94, -5.97 out-out out 14.9262 Saltbr-out 15.0816 HRD-in -71.76, -54.07 76.6, -13.3 out-out-out SNCooo out-out ActLoopNT-out 8.1118 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -115.63, 22.9 APE9-dihe-in -80.38, 148.06 APE8-dihe-in -74.58, 62.62 APE8-rot-na 35.13 APE67-dihe-in -75.74, -14.01 -52.62, -40.19 APE12-dist-na 999.0 APE11-dist-na 19.1774 APE10-dist-na 14.2129 APE9-dist-out 8.7964 None None None XRAY 2.0 0.2 0.235 A 271.0 256.0 11 29 20 9 [[402, 653]] 1.0 6di3 TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6DI5A Q06187 389 659 659.0 GJ7:701 Type1.5_Back Inactive DFGin 6.1367 13.6489 BLBplus -124.76, 169.41 59.33, 26.21 -64.33, 120.35 41.58, 90.2 76.26, -4.53 out-out out 15.3445 Saltbr-out 15.1813 HRD-in -67.75, -53.44 78.09, -12.96 out-out-out SNCooo out-out ActLoopNT-out 8.476 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -124.36, 15.12 APE9-dihe-in -72.97, 147.27 APE8-dihe-in -78.03, 63.48 APE8-rot-na 28.51 APE67-dihe-in -70.11, -10.04 -51.62, -44.66 APE12-dist-na 17.3116 APE11-dist-na 19.4898 APE10-dist-na 14.5459 APE9-dist-out 9.0259 None None None XRAY 1.42 0.179 0.195 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 6di5 TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6N9PA Q06187 389 659 659.0 KHD:701 Type1.5_Back Inactive DFGin 6.022 13.1488 BLBplus -135.16, 168.56 61.05, 24.76 -60.32, 126.3 32.73, 92.73 82.64, -10.27 out-out out 14.884 Saltbr-out 14.4647 HRD-in -74.58, -57.02 87.46, -11.61 out-out-out SNCooo out-out ActLoopNT-out 8.2289 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -130.81, 21.92 APE9-dihe-in -81.87, 143.99 APE8-dihe-in -76.35, 61.7 APE8-rot-na 35.11 APE67-dihe-in -69.01, -14.75 -47.64, -43.95 APE12-dist-na 16.9695 APE11-dist-na 19.0983 APE10-dist-na 14.2677 APE9-dist-out 8.6791 None None None XRAY 2.23 0.18 0.24 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 6n9p TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6OMUA Q06187 389 659 659.0 MZJ:702 Type1.5_Back Inactive DFGin 5.9379 13.0956 BLBplus -133.61, 168.19 58.61, 26.15 -63.54, 125.97 38.78, 91.6 73.79, -2.97 out-out out 14.6658 Saltbr-out 14.6318 HRD-in -71.55, -50.68 78.17, -9.02 out-out-out SNCooo out-out ActLoopNT-out 8.1849 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -122.21, 19.83 APE9-dihe-in -75.51, 145.29 APE8-dihe-in -79.05, 64.22 APE8-rot-na 21.1 APE67-dihe-in -72.7, -8.26 -51.72, -43.25 APE12-dist-na 16.9433 APE11-dist-na 18.9908 APE10-dist-na 14.3602 APE9-dist-out 8.9297 None None None XRAY 1.41 0.192 0.226 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 6omu TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7L5OA Q06187 389 658 659.0 R1L:701 Type1.5_Back Inactive DFGin 5.8499 13.5104 BLBplus -127.43, 169.25 53.97, 29.73 -65.91, 123.67 36.33, 92.05 77.24, -5.04 out-out out 15.1083 Saltbr-out 16.4449 HRD-in -71.18, -52.4 80.56, -12.24 out-out-out SNCooo out-out ActLoopNT-out 8.264 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -118.38, 16.38 APE9-dihe-in -74.36, 147.1 APE8-dihe-in -80.26, 62.57 APE8-rot-na 28.52 APE67-dihe-in -70.42, -8.96 -52.75, -44.25 APE12-dist-na 16.7737 APE11-dist-na 18.8715 APE10-dist-na 14.0889 APE9-dist-out 8.8053 None None None XRAY 1.21 0.166 0.178 A 271.0 267.0 3 29 29 0 [[402, 653]] 1.0 7l5o TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7L5PA Q06187 392 659 659.0 R1L:701 Type1.5_Back Inactive DFGin 6.1034 13.0374 BLBplus -151.23, 168.83 53.15, 32.8 -79.38, 131.65 40.46, 88.14 71.41, 6.82 out-out out 15.3658 Saltbr-out 15.5545 HRD-in -68.01, -52.65 77.95, -4.37 out-out-out SNCooo out-out ActLoopNT-out 7.2856 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -109.51, 12.03 APE9-dihe-in -74.87, 144.93 APE8-dihe-in -82.28, 79.26 APE8-rot-na 33.38 APE67-dihe-in -67.12, -16.82 -64.07, -43.92 APE12-dist-na 16.6835 APE11-dist-na 18.5176 APE10-dist-na 13.7311 APE9-dist-out 8.389 None None None XRAY 2.14 0.226 0.258 A 271.0 268.0 0 29 29 0 [[402, 653]] 1.0 7l5p TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7L5PB Q06187 393 658 659.0 R1L:701 Type1.5_Back Inactive DFGin 5.7994 12.6273 BLBplus -137.35, 172.01 53.29, 29.88 -71.22, 123.27 32.45, 86.8 75.33, 2.9 out-out out 13.9887 Saltbr-out 12.1619 HRD-in -68.95, -53.54 83.16, -11.2 out-out-out SNCooo out-out ActLoopNT-out 7.0472 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -108.72, 11.71 APE9-dihe-in -76.28, 141.09 APE8-dihe-in -79.7, 72.15 APE8-rot-na 35.54 APE67-dihe-in -64.78, -14.16 -60.89, -45.58 APE12-dist-na 16.8433 APE11-dist-na 18.4238 APE10-dist-na 13.4267 APE9-dist-out 8.5327 None None None XRAY 2.14 0.226 0.258 B 271.0 266.0 0 29 29 0 [[402, 653]] 1.0 7l5p TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7R60A Q06187 389 659 659.0 2IE:701 Type1.5_Back Inactive DFGin 6.5148 13.922 BLBplus -135.67, 177.92 55.11, 25.57 -60.25, 122.41 40.83, 93.29 81.76, -7.18 out-out out 15.2299 Saltbr-out 17.2398 HRD-in -74.28, -48.51 76.99, -14.13 out-out-out SNCooo out-out ActLoopNT-out 8.4373 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -124.24, 13.12 APE9-dihe-in -74.74, 147.74 APE8-dihe-in -82.8, 65.47 APE8-rot-na 27.45 APE67-dihe-in -72.09, -9.98 -50.36, -44.52 APE12-dist-na 17.2612 APE11-dist-na 19.3353 APE10-dist-na 14.3601 APE9-dist-out 9.0243 None None None XRAY 1.94 0.218 0.265 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 7r60 TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 8E2MA Q06187 389 658 659.0 UB6:701 Type1.5_Back Inactive DFGin 6.4168 13.2774 BLBplus -135.95, 175.73 60.58, 22.64 -69.16, 126.37 33.8, 94.14 80.52, -5.26 out-out out 14.842 Saltbr-out 14.6938 HRD-in -72.17, -50.81 78.81, -7.29 out-out-out SNCooo out-out ActLoopNT-out 8.3035 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -121.77, 12.85 APE9-dihe-in -73.25, 147.46 APE8-dihe-in -80.05, 65.27 APE8-rot-na 31.24 APE67-dihe-in -71.17, -9.43 -53.33, -45.23 APE12-dist-na 16.919 APE11-dist-na 19.0484 APE10-dist-na 14.2362 APE9-dist-out 9.0535 None None None XRAY 1.904 0.158 0.199 A 271.0 270.0 0 29 29 0 [[402, 653]] 1.0 8e2m TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6W7OA Q06187 396 656 659.0 TL7:60701 Type1.5_Back Inactive DFGin 5.9641 13.0637 BLBplus -130.77, 168.26 53.04, 30.28 -64.21, 121.6 37.17, 91.44 71.98, 4.56 out-out out 14.4625 Saltbr-out 15.2427 HRD-in -75.45, -50.93 78.96, -16.73 out-out-out SNCooo out-out ActLoopNT-out 8.1876 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -125.26, 14.94 APE9-dihe-in -73.36, 139.85 APE8-dihe-in -76.55, 60.58 APE8-rot-na 30.86 APE67-dihe-in -64.34, -12.26 -50.1, -48.74 APE12-dist-na 17.1583 APE11-dist-na 18.3158 APE10-dist-na 13.6743 APE9-dist-out 8.8077 None None None XRAY 2.17 0.198 0.24 A 277.0 261.0 0 29 29 0 [[402, 653]] 1.0 6w7o TYR_BTK_HUMAN TYR 6.6e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6W7OB Q06187 396 658 659.0 TL7:60701 Type1.5_Back Inactive DFGin 5.6958 13.0469 BLBplus -127.43, 170.84 53.49, 29.22 -63.0, 121.63 37.69, 90.95 76.44, -4.99 out-out out 14.4002 Saltbr-out 16.3289 HRD-in -75.03, -53.49 79.63, -12.46 out-out-out SNCooo out-out ActLoopNT-out 8.3144 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -125.25, 8.08 APE9-dihe-in -68.1, 141.15 APE8-dihe-in -74.31, 63.69 APE8-rot-na 30.16 APE67-dihe-in -66.96, -10.21 -55.5, -47.35 APE12-dist-na 17.2797 APE11-dist-na 18.9134 APE10-dist-na 14.0197 APE9-dist-out 8.9144 None None None XRAY 2.17 0.198 0.24 B 277.0 263.0 0 29 29 0 [[402, 653]] 1.0 6w7o TYR_BTK_HUMAN TYR 6.6e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6W8IC Q06187 395 657 659.0 TKY:701 Type1.5_Back Inactive DFGin 5.5583 12.8227 BLBplus -117.63, 170.82 49.97, 29.21 -63.96, 116.55 45.17, 88.86 76.02, -3.1 out-out out 14.7388 Saltbr-out 13.2847 HRD-in -79.58, -47.11 69.95, -10.05 out-out-out SNCooo out-out ActLoopNT-out 6.8084 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -64.77, -21.56 APE9-dihe-in -54.94, 130.08 APE8-dihe-in -81.13, 72.07 APE8-rot-na 26.49 APE67-dihe-in -61.37, -40.54 -59.95, -39.87 APE12-dist-na 17.6379 APE11-dist-na 18.4392 APE10-dist-na 13.269 APE9-dist-out 8.4146 None None None XRAY 3.8 0.213 0.251 C 277.0 263.0 0 29 29 0 [[402, 653]] 1.0 6w8i TYR_BTK_HUMAN TYR 6.6e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 8DSOB Q06187 392 659 659.0 TOO:701 Type1.5_Back Inactive DFGin 6.4706 13.1468 BLBplus -138.1, 175.93 59.42, 42.3 -94.78, 139.63 38.49, 72.34 77.13, -32.52 out-none out 16.7743 Saltbr-none 999.0 HRD-in -76.82, -50.13 77.08, -34.25 none-out-out SNCnoo out-out ActLoopNT-out 7.1188 ActLoopCT-out TYR APEdihe_iooai APEdist_aaao APE10-dihe-in -98.57, 164.86 APE9-dihe-out -61.48, -30.65 APE8-dihe-out -63.04, 0.9 APE8-rot-na 339.5 APE67-dihe-in -68.19, -19.53 -60.43, -34.94 APE12-dist-na 21.6921 APE11-dist-na 21.8738 APE10-dist-na 16.2509 APE9-dist-out 11.9043 None None None XRAY 2.334 0.245 0.292 B 277.0 258.0 10 29 21 8 [[402, 653]] 1.0 8dso TYR_BTK_HUMAN TYR 6.6e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 4YHFA Q06187 391 658 659.0 4C9:701 Type1.5_Back Inactive DFGin 6.3243 13.0827 BLBplus -141.4, 166.78 57.13, 26.67 -70.23, 122.45 37.58, 91.72 87.97, -7.25 out-none out 17.516 Saltbr-none 999.0 HRD-in -79.27, -46.14 75.71, -14.06 none-out-out SNCnoo out-out ActLoopNT-out 7.3496 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.55, 11.84 APE9-dihe-in -70.19, 142.86 APE8-dihe-in -78.67, 65.67 APE8-rot-na 30.17 APE67-dihe-in -65.6, -17.22 -53.11, -46.1 APE12-dist-na 16.8548 APE11-dist-na 18.4206 APE10-dist-na 14.5628 APE9-dist-out 8.6149 None None None XRAY 2.2 0.176 0.208 A 278.0 268.0 0 29 29 0 [[402, 653]] 1.0 4yhf TYR_BTK_HUMAN TYR 6.6e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 4YHFB Q06187 390 658 659.0 4C9:703 Type1.5_Back Inactive DFGin 5.4242 12.8527 BLBplus -143.9, 171.03 56.17, 27.88 -72.24, 122.6 39.36, 89.32 83.47, -7.37 out-out out 13.9304 Saltbr-out 11.7697 HRD-in -75.2, -52.89 82.94, -9.58 out-out-out SNCooo out-out ActLoopNT-out 7.105 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -91.15, 0.37 APE9-dihe-in -73.16, 140.31 APE8-dihe-in -80.39, 71.14 APE8-rot-na 31.93 APE67-dihe-in -66.78, -11.99 -60.75, -42.81 APE12-dist-na 17.038 APE11-dist-na 18.4091 APE10-dist-na 13.2525 APE9-dist-out 8.4867 None None None XRAY 2.2 0.176 0.208 B 278.0 269.0 0 29 29 0 [[402, 653]] 1.0 4yhf TYR_BTK_HUMAN TYR 6.6e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5P9IA Q06187 389 659 659.0 1E8:701 Type1.5_Back Inactive DFGin 5.8156 13.143 BLBplus -132.96, 170.25 54.94, 29.06 -65.92, 126.76 36.65, 92.12 73.44, -5.74 out-out out 14.7016 Saltbr-out 15.1827 HRD-in -73.21, -51.74 79.25, -8.77 out-out-out SNCooo out-out ActLoopNT-out 8.1669 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -117.83, 16.54 APE9-dihe-in -74.83, 144.69 APE8-dihe-in -79.03, 64.34 APE8-rot-na 27.14 APE67-dihe-in -70.64, -9.5 -53.48, -42.88 APE12-dist-na 16.9415 APE11-dist-na 18.9306 APE10-dist-na 14.1355 APE9-dist-out 8.8148 None None None XRAY 1.11 0.196 0.211 A 279.0 271.0 0 29 29 0 [[402, 653]] 1.0 5p9i TYR_BTK_HUMAN TYR 6.7e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5P9JA Q06187 394 659 659.0 8E8:701 Type1.5_Back Inactive DFGin 5.9153 13.2884 BLBplus -133.53, 169.05 56.75, 29.39 -67.86, 126.34 32.9, 92.13 74.05, -4.59 out-out out 14.625 Saltbr-out 14.8958 HRD-in -67.96, -50.37 78.37, -13.99 out-out-out SNCooo out-out ActLoopNT-out 8.1935 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -118.06, 10.3 APE9-dihe-in -68.49, 148.63 APE8-dihe-in -85.54, 61.1 APE8-rot-na 26.47 APE67-dihe-in -74.48, -9.93 -47.45, -41.8 APE12-dist-na 16.5244 APE11-dist-na 18.7267 APE10-dist-na 14.0963 APE9-dist-out 8.9073 None None None XRAY 1.08 0.21 0.224 A 279.0 263.0 3 29 26 3 [[402, 653]] 1.0 5p9j TYR_BTK_HUMAN TYR 6.7e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5P9MA Q06187 389 659 659.0 7GB:701 Type1.5_Back Inactive DFGin 5.8516 13.3293 BLBplus -132.36, 168.19 59.41, 28.36 -65.38, 123.69 35.52, 89.9 75.34, -4.93 out-out out 14.7801 Saltbr-out 15.0393 HRD-in -68.48, -50.59 79.48, -16.76 out-out-out SNCooo out-out ActLoopNT-out 8.1708 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -51.99, -28.41 APE9-dihe-in -155.94, 144.77 APE8-dihe-in -76.22, 66.03 APE8-rot-na 26.43 APE67-dihe-in -70.51, -11.44 -52.67, -42.73 APE12-dist-na 16.2836 APE11-dist-na 16.7244 APE10-dist-na 16.1093 APE9-dist-out 8.8831 None None None XRAY 1.41 0.18 0.201 A 279.0 271.0 0 29 29 0 [[402, 653]] 1.0 5p9m TYR_BTK_HUMAN TYR 6.7e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 3GENA Q06187 392 658 659.0 B43:1 Type1.5_Back Inactive DFGin 5.9158 13.0055 BLBplus -134.69, 169.57 56.28, 25.37 -64.74, 122.88 36.07, 90.43 78.22, -5.97 out-out out 14.6829 Saltbr-out 14.598 HRD-in -73.9, -49.88 78.36, -14.16 out-out-out SNCooo out-out ActLoopNT-out 8.1654 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -118.65, 5.65 APE9-dihe-in -71.16, 141.23 APE8-dihe-in -74.25, 62.53 APE8-rot-na 28.89 APE67-dihe-in -70.5, -10.0 -52.03, -42.55 APE12-dist-na 16.9751 APE11-dist-na 18.9384 APE10-dist-na 13.9381 APE9-dist-out 8.8324 None None None XRAY 1.6 0.195 0.232 A 283.0 264.0 3 29 29 0 [[402, 653]] 1.0 3gen TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6E4FA Q06187 389 658 659.0 HRA:701 Type1.5_Back Inactive DFGin 6.1396 13.5953 BLBplus -125.51, 171.21 65.06, 21.65 -65.55, 123.81 39.55, 91.62 75.8, -3.81 out-out out 14.8801 Saltbr-out 17.078 HRD-in -70.37, -51.25 79.25, -11.85 out-out-out SNCooo out-out ActLoopNT-out 8.1679 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.58, 7.18 APE9-dihe-in -70.93, 142.86 APE8-dihe-in -80.71, 63.54 APE8-rot-na 29.0 APE67-dihe-in -70.94, -8.1 -51.86, -45.52 APE12-dist-na 16.8591 APE11-dist-na 18.4793 APE10-dist-na 13.6257 APE9-dist-out 8.7071 None None None XRAY 1.15 0.131 0.15 A 290.0 270.0 0 29 29 0 [[402, 653]] 1.0 6e4f TYR_BTK_HUMAN TYR 7.8e-93 316.5 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5FBOA Q06187 392 659 659.0 5WH:1001,5WE:1002 Type1.5_Back,Allosteric Inactive DFGin 4.9335 14.0794 BLBplus -127.34, -179.25 51.08, 30.68 -63.41, 107.22 34.59, 90.39 57.28, 50.21 out-out out 11.9542 Saltbr-out 14.2301 HRD-in -61.25, -46.68 71.35, -12.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.03, 2.31 APE9-dihe-in -65.0, 140.35 APE8-dihe-in -74.92, 62.27 APE8-rot-na 32.17 APE67-dihe-in -71.92, -9.91 -51.18, -45.3 APE12-dist-na 999.0 APE11-dist-na 17.4062 APE10-dist-na 13.1956 APE9-dist-out 8.1123 None None None XRAY 1.894 0.212 0.236 A 271.0 255.0 13 29 16 13 [[402, 653]] 1.0 5fbo TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 8FLNA Q06187 395 657 659.0 Y7W:701,BTB:705 Type1.5_Front,Allosteric Inactive DFGin 5.5559 14.0954 BLBplus -121.98, 170.19 56.55, 34.27 -69.53, 121.06 33.29, 92.29 82.95, 0.33 out-out out 16.422 Saltbr-out 17.9428 HRD-in -75.91, -54.85 81.87, -11.12 out-out-out SNCooo out-out ActLoopNT-out 7.5944 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -104.55, 8.91 APE9-dihe-in -70.03, 146.41 APE8-dihe-in -76.42, 62.91 APE8-rot-na 20.16 APE67-dihe-in -67.77, -10.54 -54.41, -41.28 APE12-dist-na 16.7992 APE11-dist-na 19.0582 APE10-dist-na 14.3578 APE9-dist-out 8.5866 None None None XRAY 1.334 0.193 0.199 A 273.0 263.0 0 29 29 0 [[402, 653]] 1.0 8fln TYR_BTK_HUMAN TYR 4.6e-93 317.2 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5FBNC Q06187 395 658 659.0 5WF:701,5WE:702 Type1.5_Front,Allosteric Inactive DFGin 6.2343 13.4854 BLBplus -138.97, 172.93 64.41, 21.2 -64.91, 134.85 43.34, 89.93 78.28, -17.1 out-out out 15.0072 Saltbr-out 15.714 HRD-in -67.81, -54.89 86.66, -24.42 out-out-out SNCooo out-out ActLoopNT-out 8.1944 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out 143.31, -31.01 APE9-dihe-in -63.12, 135.49 APE8-dihe-in -76.38, 65.1 APE8-rot-na 32.35 APE67-dihe-in -72.98, -10.12 -50.46, -47.16 APE12-dist-na 999.0 APE11-dist-na 17.8308 APE10-dist-na 12.6083 APE9-dist-out 8.1809 None None None XRAY 1.8 0.182 0.226 C 271.0 256.0 8 29 21 8 [[402, 653]] 1.0 5fbn TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6X3OA Q06187 395 659 659.0 ULY:701,5WE:702 Type1.5_Front,Allosteric Inactive DFGin 6.2723 14.2227 BLBplus -137.77, 172.12 61.73, 21.35 -60.85, 127.83 37.95, 92.24 73.87, -6.38 out-out out 15.17 Saltbr-out 16.0811 HRD-in -75.67, -53.5 81.79, -14.06 out-out-out SNCooo out-out ActLoopNT-out 8.4586 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -109.73, 7.42 APE9-dihe-in -70.0, 142.33 APE8-dihe-in -75.39, 64.77 APE8-rot-na 34.47 APE67-dihe-in -69.38, -11.52 -56.58, -43.22 APE12-dist-na 16.806 APE11-dist-na 18.6039 APE10-dist-na 13.6409 APE9-dist-out 8.5906 None None None XRAY 1.9 0.181 0.213 A 271.0 265.0 0 29 29 0 [[402, 653]] 1.0 6x3o TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6X3OB Q06187 393 659 659.0 ULY:701,5WE:702 Type1.5_Front,Allosteric Inactive DFGin 6.2875 14.0893 BLBplus -138.35, 171.76 61.86, 21.21 -60.49, 128.12 38.08, 92.33 72.6, -5.67 out-out out 15.3768 Saltbr-out 16.6794 HRD-in -75.8, -53.34 80.45, -11.96 out-out-out SNCooo out-out ActLoopNT-out 8.3968 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -114.41, 10.63 APE9-dihe-in -69.48, 144.31 APE8-dihe-in -76.78, 65.24 APE8-rot-na 34.23 APE67-dihe-in -70.15, -10.73 -56.21, -43.96 APE12-dist-na 16.68 APE11-dist-na 18.4631 APE10-dist-na 13.5744 APE9-dist-out 8.483 None None None XRAY 1.9 0.181 0.213 B 271.0 267.0 0 29 29 0 [[402, 653]] 1.0 6x3o TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 8FLLA Q06187 395 658 659.0 Y7W:701,BTB:705 Type1.5_Front,Allosteric Inactive DFGin 5.5931 14.0905 BLBplus -122.49, 170.09 55.08, 30.22 -63.61, 119.39 33.22, 95.24 81.67, 3.52 out-none out 16.3522 Saltbr-none 999.0 HRD-in -74.39, -53.68 82.2, -12.98 none-out-out SNCnoo out-out ActLoopNT-out 7.5618 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.74, 7.32 APE9-dihe-in -70.19, 146.45 APE8-dihe-in -76.31, 63.24 APE8-rot-na 25.19 APE67-dihe-in -68.43, -11.11 -54.01, -42.0 APE12-dist-na 16.7425 APE11-dist-na 18.9367 APE10-dist-na 14.2647 APE9-dist-out 8.5135 None None None XRAY 1.498 0.186 0.202 A 273.0 264.0 0 29 29 0 [[402, 653]] 1.0 8fll TYR_BTK_HUMAN TYR 6.2e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5FBND Q06187 394 658 659.0 5WF:702,5WE:703,5WE:704,5WE:705 Type1.5_Front,Allosteric,Allosteric,Allosteric Inactive DFGin 6.2504 13.4724 BLBplus -137.76, 172.64 65.66, 19.16 -62.24, 135.48 45.56, 88.91 74.32, -16.76 out-out out 15.0558 Saltbr-out 15.7515 HRD-in -65.32, -54.88 86.04, -26.38 out-out-none SNCoon out-none ActLoopNT-out 8.1947 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.18 APE8-dihe-in -78.24, 64.6 APE8-rot-na 31.95 APE67-dihe-in -74.36, -8.3 -50.81, -46.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8979 None None None XRAY 1.8 0.182 0.226 D 271.0 255.0 10 29 19 10 [[402, 653]] 1.0 5fbn TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6X3PA Q06187 394 659 659.0 UM4:701,UM4:702,BTB:704 Type1.5_Front,Allosteric,Type1 Inactive DFGin 6.3555 13.7902 BLBplus -142.49, 179.49 63.69, 18.67 -57.75, 127.0 32.08, 89.29 76.23, -5.08 out-out out 15.1688 Saltbr-out 16.3473 HRD-in -78.69, -54.16 80.75, -12.21 out-out-out SNCooo out-out ActLoopNT-out 8.6625 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -108.53, 5.56 APE9-dihe-in -69.62, 142.82 APE8-dihe-in -80.89, 62.04 APE8-rot-na 33.01 APE67-dihe-in -69.33, -8.25 -49.92, -44.89 APE12-dist-na 16.7678 APE11-dist-na 18.5649 APE10-dist-na 13.5987 APE9-dist-out 8.7681 None None None XRAY 1.34 0.205 0.217 A 271.0 266.0 0 29 29 0 [[402, 653]] 1.0 6x3p TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 3PIYA Q06187 391 658 659.0 585:1 Type1 Inactive DFGin 6.5898 14.8046 None -86.48, 116.32 -39.12, -55.85 -103.57, 159.77 292.78, 91.05 -55.45, 135.27 out-out out 10.5998 Saltbr-out 6.1662 HRD-in -82.22, -47.83 77.57, -19.27 out-out-out SNCooo out-out ActLoopNT-out 14.1198 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.57, 20.38 APE9-dihe-in -77.53, 136.74 APE8-dihe-in -77.13, 67.95 APE8-rot-na 32.82 APE67-dihe-in -63.75, -20.32 -55.08, -51.26 APE12-dist-na 17.7544 APE11-dist-na 17.7304 APE10-dist-na 12.4391 APE9-dist-out 8.1766 None None None XRAY 2.55 0.228 0.295 A 274.0 262.0 6 29 29 0 [[402, 653]] 1.0 3piy TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 3PJ2A Q06187 391 659 659.0 04K:1 Type1.5_Back Inactive DFGin 4.8792 13.7655 None -125.57, -174.91 51.36, 35.37 -74.45, 999.0 30.81, 92.87 999.0, 999.0 out-out out 10.8742 Saltbr-out 6.4644 HRD-in -71.49, -54.79 77.51, -7.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.76 APE8-dihe-in -75.06, 65.46 APE8-rot-na 29.28 APE67-dihe-in -67.05, -14.12 -51.89, -45.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1661 None None None XRAY 1.75 0.231 0.263 A 274.0 248.0 21 29 11 18 [[402, 653]] 1.0 3pj2 TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5XYZA Q06187 394 656 659.0 GYL:701 Type1 Inactive DFGinter 9.3469 8.304 BABtrans -99.77, 139.1 -95.47, 13.14 -102.26, 131.3 176.17, 60.97 88.39, 12.77 out-out out 11.5781 Saltbr-out 9.2547 HRD-in -78.14, -61.12 90.65, -27.42 out-out-none SNCoon out-none ActLoopNT-out 5.2282 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 77.34 APE8-dihe-in -83.17, 111.34 APE8-rot-na 20.92 APE67-dihe-in -73.15, -5.2 -57.61, -54.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.4949 None None None XRAY 2.64 0.268 0.326 A 265.0 230.0 33 29 15 14 [[402, 653]] 1.0 5xyz TYR_BTK_HUMAN TYR 5.5e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 5XYZB Q06187 394 656 659.0 GYL:701 Type1 Inactive DFGinter 9.4328 8.0755 BABtrans -80.9, 137.65 -92.66, -0.21 -77.59, 136.6 176.7, 69.08 72.83, 36.08 out-out out 11.3866 Saltbr-out 9.6743 HRD-in -68.79, -59.6 106.37, -54.65 out-out-none SNCoon out-none ActLoopNT-out 5.327 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 75.53 APE8-dihe-in -66.49, 110.19 APE8-rot-na 22.3 APE67-dihe-in -70.95, -22.66 -57.21, -50.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6562 None None None XRAY 2.64 0.268 0.326 B 265.0 234.0 29 29 15 14 [[402, 653]] 1.0 5xyz TYR_BTK_HUMAN TYR 5.5e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 7YC9A Q06187 395 658 659.0 IS4:701 Type1 Inactive DFGinter 8.002 8.7887 BABtrans -86.32, 131.84 -104.1, 6.91 -65.2, 125.85 176.47, 71.74 60.46, 29.78 out-out out 11.7136 Saltbr-out 13.1685 HRD-in -89.69, -58.41 77.25, -3.96 out-out-in SNCooi out-in ActLoopNT-out 8.7115 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.07, 157.14 APE9-dihe-in -156.9, 156.06 APE8-dihe-in -80.91, 97.28 APE8-rot-na 28.13 APE67-dihe-in -74.5, -5.29 -49.69, -51.23 APE12-dist-na 18.2489 APE11-dist-na 16.1716 APE10-dist-na 13.5257 APE9-dist-in 6.316 None None None XRAY 1.4 0.167 0.187 A 269.0 264.0 0 29 29 0 [[402, 653]] 1.0 7yc9 TYR_BTK_HUMAN TYR 5.9e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 3OCTA Q06187 394 656 659.0 1N1:663 Type1 Inactive DFGinter 9.5513 8.0475 BABtrans -83.49, 139.01 -103.95, 15.92 -87.02, 132.92 181.28, 97.3 77.87, 26.97 in-out in 9.203 Saltbr-out 7.7453 HRD-in -70.28, -48.13 67.57, -13.36 out-out-none SNCoon out-none ActLoopNT-out 5.3805 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 95.42 APE8-dihe-in -60.66, 106.57 APE8-rot-na 28.18 APE67-dihe-in -77.0, -13.84 -55.35, -41.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.7096 V555R None None XRAY 1.95 0.199 0.251 A 265.0 244.0 19 29 15 14 [[402, 653]] 1.0 3oct TYR_BTK_HUMAN TYR 2.3e-93 318.2 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 6NFIA Q06187 392 659 659.0 KLP:701 Type1 Inactive DFGinter 9.1428 7.9961 None -88.38, 102.06 -66.25, -30.62 -22.04, 98.6 180.01, 49.84 74.77, 999.0 out-out out 10.7923 Saltbr-out 7.7832 HRD-in -72.39, -52.0 75.98, -4.69 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 84.4 APE9-dihe-in -72.68, 133.55 APE8-dihe-in -78.11, 68.48 APE8-rot-na 34.66 APE67-dihe-in -67.64, -17.9 -60.47, -41.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.4316 None None None XRAY 2.41 0.22 0.248 A 268.0 243.0 25 29 13 16 [[402, 653]] 1.0 6nfi TYR_BTK_HUMAN TYR 5.8e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK 3PJ3A Q06187 391 659 659.0 04L:1 Type1 Inactive None 999.0 999.0 None -130.95, -155.74 -154.88, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.4381 Saltbr-in 3.5253 HRD-in -72.1, -53.46 75.95, -3.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.29 APE8-dihe-in -70.28, 66.1 APE8-rot-na 28.08 APE67-dihe-in -69.44, -11.85 -54.05, -43.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3186 None None None XRAY 1.85 0.234 0.254 A 274.0 240.0 29 29 10 19 [[402, 653]] 1.0 3pj3 TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK

TYR_BTK (Tyrosine-protein kinase BTK)

Total number of chains: 171
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 155 90.6% 6DI1A
DFGinter BABtrans 6 3.5% 7YC9A
DFGin BLAplus 4 2.3% 1K2PA
DFGin BLAminus 2 1.2% AF-Q06187-K1A
DFGin None 2 1.2% 3PIYA
DFGinter None 1 0.6% 6NFIA
None None 1 0.6% 3PJ3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
BTK Q3ZC95_BOVIN 4Y95A Q3ZC95 395 659 659.0 746:60701 Type1 Inactive DFGin 6.6175 13.8598 BLBplus -121.38, 150.87 56.6, 35.77 -63.21, 129.98 38.15, 94.63 78.92, -1.55 out-out out 14.6244 Saltbr-out 16.1857 HRD-in -73.49, -58.3 84.27, -8.32 out-out-out SNCooo out-out ActLoopNT-out 7.9226 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -110.52, -5.28 APE9-dihe-in -66.23, 137.47 APE8-dihe-in -79.05, 62.77 APE8-rot-na 30.72 APE67-dihe-in -77.89, -2.13 -54.11, -40.82 APE12-dist-na 17.5052 APE11-dist-na 19.1412 APE10-dist-na 14.0853 APE9-dist-out 8.6558 L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P None None XRAY 1.599 0.155 0.184 A 266.0 265.0 0 29 29 0 [[402, 653]] 1.0 4y95 Bos taurus TYR_BTK_BOVIN TYR 1.4e-93 318.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase
BTK Q3ZC95_BOVIN 4Y95D Q3ZC95 395 659 659.0 746:60701 Type1 Inactive DFGin 6.6489 13.8623 BLBplus -120.58, 150.23 57.17, 35.26 -62.33, 130.63 38.01, 95.62 77.89, -2.4 out-out out 14.6289 Saltbr-out 16.219 HRD-in -73.6, -57.75 84.35, -9.39 out-out-out SNCooo out-out ActLoopNT-out 7.9005 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -110.57, -5.62 APE9-dihe-in -65.7, 137.52 APE8-dihe-in -78.52, 62.83 APE8-rot-na 30.81 APE67-dihe-in -77.8, -1.14 -54.26, -41.32 APE12-dist-na 17.5167 APE11-dist-na 19.15 APE10-dist-na 14.0784 APE9-dist-out 8.6269 L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P None None XRAY 1.599 0.155 0.184 D 266.0 265.0 0 29 29 0 [[402, 653]] 1.0 4y95 Bos taurus TYR_BTK_BOVIN TYR 1.4e-93 318.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase
BTK Q3ZC95_BOVIN 4Y93A Q3ZC95 1 658 659.0 746:60702 Type1 Inactive DFGin 6.8872 13.6546 BLBplus -120.16, 153.49 55.57, 32.74 -63.12, 134.52 38.43, 96.44 76.83, -2.76 out-out out 15.7792 Saltbr-out 13.6789 HRD-in -75.84, -56.25 76.77, -5.42 out-out-out SNCooo out-out ActLoopNT-out 7.8847 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.38, -2.7 APE9-dihe-in -68.4, 140.07 APE8-dihe-in -79.2, 65.9 APE8-rot-na 33.51 APE67-dihe-in -78.01, -3.3 -55.32, -41.07 APE12-dist-na 17.5147 APE11-dist-na 19.1062 APE10-dist-na 14.1547 APE9-dist-out 8.5977 L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 1.695 0.159 0.195 A 446.0 426.0 0 29 29 0 [[402, 653]] 1.0 4y93 Bos taurus TYR_BTK_BOVIN TYR 6.5e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase
BTK Q3ZC95_BOVIN 4Y95B Q3ZC95 395 659 659.0 746:60701,PE4:60705 Type1,Allosteric Inactive DFGin 6.2838 14.0698 BLBplus -118.87, 151.9 58.51, 36.48 -63.81, 131.39 36.51, 95.01 77.72, -1.04 out-out out 14.5981 Saltbr-out 16.1022 HRD-in -74.38, -57.15 83.98, -6.38 out-out-out SNCooo out-out ActLoopNT-out 8.1264 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -110.28, -7.21 APE9-dihe-in -68.34, 135.25 APE8-dihe-in -80.18, 64.43 APE8-rot-na 29.96 APE67-dihe-in -80.41, -0.39 -53.51, -41.68 APE12-dist-na 17.4878 APE11-dist-na 18.9412 APE10-dist-na 13.9012 APE9-dist-out 8.7509 L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P None None XRAY 1.599 0.155 0.184 B 266.0 265.0 0 29 29 0 [[402, 653]] 1.0 4y95 Bos taurus TYR_BTK_BOVIN TYR 1.4e-93 318.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase
BTK Q3ZC95_BOVIN 4Y95C Q3ZC95 395 659 659.0 746:61001,PE4:61004 Type1,Allosteric Inactive DFGin 6.2611 14.0342 BLBplus -119.16, 152.8 57.59, 36.19 -63.2, 130.69 37.21, 95.75 78.07, -1.63 out-out out 14.6057 Saltbr-out 16.1522 HRD-in -74.98, -51.44 82.75, -9.25 out-out-out SNCooo out-out ActLoopNT-out 8.1038 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.01, -6.79 APE9-dihe-in -68.05, 136.6 APE8-dihe-in -80.31, 63.53 APE8-rot-na 30.49 APE67-dihe-in -79.73, -0.13 -53.01, -42.36 APE12-dist-na 17.506 APE11-dist-na 18.9727 APE10-dist-na 13.9266 APE9-dist-out 8.8005 L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P None None XRAY 1.599 0.155 0.184 C 266.0 265.0 0 29 29 0 [[402, 653]] 1.0 4y95 Bos taurus TYR_BTK_BOVIN TYR 1.4e-93 318.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase
BTK BTK_HUMAN AF-Q06187-K1A Q06187 394 659 659.0 No_ligand No_ligand Active DFGin 6.6004 13.573 BLAminus -136.86, -178.35 58.88, 65.72 -79.63, 17.44 303.15, 95.81 -59.47, -35.89 in-in in 8.3739 Saltbr-in 2.6582 HRD-in -82.15, -43.22 66.84, -17.66 in-in-in SNCiii in-in ActLoopNT-in 2.8953 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.5, 145.43 APE9-dihe-in -141.06, 156.51 APE8-dihe-in -76.86, 86.05 APE8-rot-na 33.19 APE67-dihe-in -71.15, -13.64 -39.83, -42.64 APE12-dist-na 14.9168 APE11-dist-na 10.113 APE10-dist-na 11.7731 APE9-dist-in 6.7406 None None None AF2 -1.0 1.0 1.0 A 266.0 266.0 0 29 29 0 [[402, 653]] 1.0 AF-Q06187-K1 Homo sapiens TYR_BTK_HUMAN TYR 5.6e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN AF-Q06187-K3A Q06187 394 659 659.0 No_ligand No_ligand Active DFGin 6.1019 13.8994 BLAminus -145.41, -175.94 66.17, 62.18 -83.37, 7.8 301.85, 98.96 -63.25, -28.92 in-in in 8.3689 Saltbr-in 2.681 HRD-in -81.43, -44.92 68.23, -10.51 in-in-in SNCiii in-in ActLoopNT-in 2.8809 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.17, 138.32 APE9-dihe-in -148.99, 160.92 APE8-dihe-in -83.4, 78.18 APE8-rot-na 37.74 APE67-dihe-in -68.88, -18.16 -34.0, -49.11 APE12-dist-na 14.4676 APE11-dist-na 9.7184 APE10-dist-na 9.98 APE9-dist-in 5.5801 None None None AF2 -1.0 1.0 1.0 A 266.0 266.0 0 29 29 0 [[402, 653]] 1.0 AF-Q06187-K3 Homo sapiens TYR_BTK_HUMAN TYR 5.6e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 1K2PA Q06187 397 654 659.0 No_ligand No_ligand Inactive DFGin 6.2691 13.6092 BLAplus -137.21, -161.69 45.76, 46.11 -111.57, 23.49 52.19, 85.05 -57.85, -62.14 out-out out 13.2869 Saltbr-out 10.6239 HRD-out -102.12, 102.51 -76.81, 5.84 out-in-out SNCoio in-out ActLoopNT-in 3.3416 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -178.37, 168.38 APE9-dihe-in -137.01, 135.64 APE8-dihe-in -77.95, 68.38 APE8-rot-na 27.72 APE67-dihe-in -66.74, -7.07 -47.38, -37.03 APE12-dist-na 14.5076 APE11-dist-na 13.5124 APE10-dist-na 15.7561 APE9-dist-out 8.121 None None None XRAY 2.1 0.28 0.287 A 263.0 258.0 0 29 29 0 [[402, 653]] 1.0 1k2p Homo sapiens TYR_BTK_HUMAN TYR 5.4e-93 317.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 3K54A Q06187 392 658 659.0 1N1:1 Type1 Inactive DFGin 4.6816 13.9981 BLAplus -132.68, -179.17 50.27, 30.98 -93.41, -0.42 58.12, 86.77 -82.65, 999.0 in-out in 8.7866 Saltbr-out 3.7709 HRD-in -69.54, -47.61 72.38, -12.01 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.06 APE8-dihe-in -84.11, 69.82 APE8-rot-na 29.89 APE67-dihe-in -70.22, -9.36 -47.67, -47.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1055 Y551E None None XRAY 1.94 0.202 0.258 A 283.0 243.0 24 29 12 17 [[402, 653]] 1.0 3k54 Homo sapiens TYR_BTK_HUMAN TYR 1.6e-92 315.4 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 3PIZA Q06187 391 659 659.0 03C:1 Type1 Inactive DFGin 4.8889 14.1264 BLAplus -126.33, -179.6 57.13, 22.66 -85.31, -11.74 58.57, 94.3 -83.53, -14.98 in-in in 7.9755 Saltbr-in 2.76 HRD-in -82.17, -49.28 74.06, -8.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.57 APE8-dihe-in -71.57, 69.01 APE8-rot-na 28.32 APE67-dihe-in -70.88, -14.79 -58.9, -38.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2112 None None None XRAY 2.21 0.228 0.282 A 274.0 245.0 24 29 13 16 [[402, 653]] 1.0 3piz Homo sapiens TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 3PJ1A Q06187 391 659 659.0 LHL:1,LHL:2 Type1,Allosteric Inactive DFGin 4.6315 13.9108 BLAplus -125.24, -177.97 47.53, 37.44 -91.22, -16.21 57.77, 94.29 -84.9, -7.73 in-in in 8.2391 Saltbr-in 3.0498 HRD-in -71.17, -51.36 76.56, -15.56 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.95 APE8-dihe-in -68.38, 60.28 APE8-rot-na 27.48 APE67-dihe-in -69.28, -12.51 -52.55, -45.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1998 None None None XRAY 2.0 0.223 0.257 A 274.0 241.0 28 29 13 16 [[402, 653]] 1.0 3pj1 Homo sapiens TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 1K2PB Q06187 397 654 659.0 No_ligand No_ligand Inactive DFGin 6.457 13.1625 BLBplus -139.6, -161.19 59.0, 26.74 -105.15, 158.18 56.54, 91.73 152.19, -71.86 out-out out 12.9943 Saltbr-out 10.301 HRD-in -87.21, -28.6 73.87, -41.31 out-in-out SNCoio in-out ActLoopNT-in 2.7353 ActLoopCT-out TYR APEdihe_iioao APEdist_aaai APE10-dihe-in -120.27, 103.13 APE9-dihe-in -86.88, 165.1 APE8-dihe-out -60.59, -22.28 APE8-rot-na 27.98 APE67-dihe-out -58.09, -40.25 73.96, -61.99 APE12-dist-na 16.6499 APE11-dist-na 13.4797 APE10-dist-na 16.127 APE9-dist-in 7.2691 None None None XRAY 2.1 0.28 0.287 B 263.0 258.0 0 29 29 0 [[402, 653]] 1.0 1k2p Homo sapiens TYR_BTK_HUMAN TYR 5.4e-93 317.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 8YVVA Q06187 394 658 659.0 No_ligand No_ligand Inactive DFGin 5.9975 13.8277 BLBplus -134.73, -178.16 59.38, 44.59 -109.86, 142.64 55.87, 84.85 77.65, -67.74 out-out out 14.3246 Saltbr-out 15.544 HRD-in -75.34, -58.82 89.51, -11.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -123.34, 14.3 APE9-dihe-in -77.59, 136.04 APE8-dihe-in -77.96, 72.48 APE8-rot-na 34.0 APE67-dihe-in -72.74, -9.49 -60.94, -40.0 APE12-dist-na 22.471 APE11-dist-na 19.5489 APE10-dist-na 15.1318 APE9-dist-out 8.4964 None None None XRAY 2.25 0.211 0.266 A 266.0 262.0 3 29 28 1 [[402, 653]] 1.0 8yvv Homo sapiens TYR_BTK_HUMAN TYR 5.6e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 8YVVB Q06187 395 658 659.0 No_ligand No_ligand Inactive DFGin 6.0135 13.8585 BLBplus -134.8, -177.27 59.8, 43.75 -110.54, 141.4 55.94, 96.02 79.54, -66.86 out-out out 14.2328 Saltbr-out 14.8275 HRD-in -75.12, -58.7 89.76, -10.72 out-out-none SNCoon out-none ActLoopNT-out 12.1423 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 69.43 APE8-rot-na 32.53 APE67-dihe-in -73.72, -9.32 -60.74, -39.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.211 0.266 B 266.0 247.0 17 29 14 15 [[402, 653]] 1.0 8yvv Homo sapiens TYR_BTK_HUMAN TYR 5.6e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 3P08A Q06187 394 658 659.0 No_ligand No_ligand Inactive DFGin 5.9549 13.9444 BLBplus -128.06, -177.49 61.21, 39.22 -106.08, 150.25 54.53, 96.35 80.6, -131.41 out-out out 14.116 Saltbr-out 14.9362 HRD-in -72.42, -56.09 86.22, -18.05 out-out-out SNCooo out-out ActLoopNT-out 9.5034 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -55.21 APE9-dihe-in -164.04, 136.13 APE8-dihe-in -66.05, 54.59 APE8-rot-na 27.48 APE67-dihe-in -71.49, -7.26 -51.24, -42.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 19.3141 APE9-dist-out 8.5786 None None None XRAY 2.3 0.228 0.278 A 267.0 252.0 13 29 16 13 [[402, 653]] 1.0 3p08 Homo sapiens TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 3P08B Q06187 395 658 659.0 No_ligand No_ligand Inactive DFGin 5.9243 13.8923 BLBplus -127.17, -176.76 62.02, 37.83 -105.43, 144.29 55.2, 95.38 69.79, -51.59 out-out out 14.0388 Saltbr-out 15.0143 HRD-in -68.66, -56.62 86.42, -18.8 out-out-out SNCooo out-out ActLoopNT-out 10.4665 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.87 APE8-dihe-in -65.06, 55.73 APE8-rot-na 340.87 APE67-dihe-in -75.43, -6.18 -53.16, -39.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.4743 None None None XRAY 2.3 0.228 0.278 B 267.0 258.0 6 29 23 6 [[402, 653]] 1.0 3p08 Homo sapiens TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6W8IA Q06187 393 657 659.0 No_ligand No_ligand Inactive DFGin 5.4944 13.1493 BLBplus -141.69, -178.02 52.95, 31.02 -75.34, 135.29 30.84, 76.13 77.64, -19.59 out-none out 11.5703 Saltbr-none 999.0 HRD-in -72.89, -30.35 63.34, -9.06 none-out-out SNCnoo out-out ActLoopNT-out 8.0199 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -49.9 APE9-dihe-in -70.68, 142.5 APE8-dihe-in -77.28, 76.89 APE8-rot-na 26.43 APE67-dihe-in -62.4, -20.85 -66.35, -47.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.3527 APE9-dist-out 8.7279 None None None XRAY 3.8 0.213 0.251 A 277.0 254.0 11 29 18 11 [[402, 653]] 1.0 6w8i Homo sapiens TYR_BTK_HUMAN TYR 6.6e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6W8IB Q06187 395 657 659.0 No_ligand No_ligand Inactive DFGin 5.525 13.3295 BLBplus -125.64, 175.83 52.48, 26.01 -70.56, 126.21 48.5, 99.48 77.88, -23.39 out-out out 14.815 Saltbr-out 11.6934 HRD-in -73.94, -52.14 71.09, -15.22 out-out-out SNCooo out-out ActLoopNT-out 7.3025 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.0 APE8-dihe-in -77.84, 75.97 APE8-rot-na 24.72 APE67-dihe-in -59.64, -37.38 -63.18, -50.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.3414 None None None XRAY 3.8 0.213 0.251 B 277.0 251.0 12 29 17 12 [[402, 653]] 1.0 6w8i Homo sapiens TYR_BTK_HUMAN TYR 6.6e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 4NWMA Q06187 396 657 659.0 2P5:60701 Type1 Inactive DFGin 6.2366 13.5473 BLBplus -124.36, 162.2 58.0, 30.8 -65.9, 131.67 37.39, 93.38 75.76, -5.81 out-none out 15.7388 Saltbr-none 999.0 HRD-in -75.22, -56.08 81.81, -11.35 none-out-out SNCnoo out-out ActLoopNT-out 7.4406 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -104.06, -3.18 APE9-dihe-in -62.5, 137.94 APE8-dihe-in -76.17, 67.69 APE8-rot-na 29.81 APE67-dihe-in -67.16, -10.51 -55.62, -44.66 APE12-dist-na 17.5081 APE11-dist-na 19.1435 APE10-dist-na 14.0443 APE9-dist-out 8.5218 None None OCS481 XRAY 2.03 0.197 0.234 A 263.0 261.0 1 29 29 0 [[402, 653]] 1.0 4nwm Homo sapiens TYR_BTK_HUMAN TYR 5.4e-93 317.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 4NWMB Q06187 396 657 659.0 2P5:60701 Type1 Inactive DFGin 6.136 13.8027 BLBplus -123.62, 161.4 58.54, 30.74 -65.95, 131.21 37.43, 94.6 74.49, -3.43 out-none out 14.7614 Saltbr-none 999.0 HRD-in -74.43, -56.79 83.89, -12.84 none-out-out SNCnoo out-out ActLoopNT-out 7.4869 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -104.71, -3.65 APE9-dihe-in -64.14, 139.49 APE8-dihe-in -76.31, 69.39 APE8-rot-na 29.79 APE67-dihe-in -66.98, -8.96 -53.75, -47.41 APE12-dist-na 17.2896 APE11-dist-na 19.1988 APE10-dist-na 14.1826 APE9-dist-out 8.4816 None None OCS481 XRAY 2.03 0.197 0.234 B 263.0 261.0 1 29 29 0 [[402, 653]] 1.0 4nwm Homo sapiens TYR_BTK_HUMAN TYR 5.4e-93 317.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6AUBA Q06187 395 657 659.0 BXM:60703 Type1 Inactive DFGin 6.181 13.7035 BLBplus -120.63, 149.92 61.48, 31.96 -57.12, 132.62 37.58, 95.01 82.18, -15.5 out-out out 16.4107 Saltbr-out 16.4116 HRD-in -73.54, -57.51 84.74, -16.58 out-out-out SNCooo out-out ActLoopNT-out 7.6247 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -104.04, -6.45 APE9-dihe-in -61.75, 141.0 APE8-dihe-in -78.36, 61.51 APE8-rot-na 29.02 APE67-dihe-in -70.89, -7.8 -56.63, -43.29 APE12-dist-na 17.6153 APE11-dist-na 19.0984 APE10-dist-na 13.8646 APE9-dist-out 8.5418 None None None XRAY 1.65 0.166 0.199 A 264.0 263.0 0 29 29 0 [[402, 653]] 1.0 6aub Homo sapiens TYR_BTK_HUMAN TYR 5.5e-93 317.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6S90A Q06187 395 656 659.0 L0Z:701 Type1 Inactive DFGin 6.1122 13.79 BLBplus -115.31, 156.37 55.47, 33.74 -62.04, 130.58 34.96, 96.83 75.01, -11.68 out-out out 16.0674 Saltbr-out 16.1976 HRD-in -72.51, -52.76 82.17, -15.84 out-out-out SNCooo out-out ActLoopNT-out 7.4778 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -106.99, -6.85 APE9-dihe-in -64.19, 138.56 APE8-dihe-in -76.5, 60.12 APE8-rot-na 32.24 APE67-dihe-in -73.04, -6.49 -53.3, -46.98 APE12-dist-na 17.3407 APE11-dist-na 18.6749 APE10-dist-na 13.5553 APE9-dist-out 8.3686 None None None XRAY 1.82 0.169 0.201 A 266.0 262.0 0 29 29 0 [[402, 653]] 1.0 6s90 Homo sapiens TYR_BTK_HUMAN TYR 5.6e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6S90B Q06187 395 656 659.0 L0Z:701 Type1 Inactive DFGin 6.1085 13.8622 BLBplus -116.19, 155.66 56.11, 33.52 -61.22, 131.45 35.37, 97.17 75.29, -12.88 out-out out 16.087 Saltbr-out 16.1894 HRD-in -72.06, -53.36 83.12, -14.11 out-out-out SNCooo out-out ActLoopNT-out 7.4687 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -104.9, -7.1 APE9-dihe-in -63.27, 138.96 APE8-dihe-in -77.53, 59.25 APE8-rot-na 32.06 APE67-dihe-in -69.99, -10.14 -54.04, -43.78 APE12-dist-na 17.3739 APE11-dist-na 18.7144 APE10-dist-na 13.5827 APE9-dist-out 8.3819 None None None XRAY 1.82 0.169 0.201 B 266.0 262.0 0 29 29 0 [[402, 653]] 1.0 6s90 Homo sapiens TYR_BTK_HUMAN TYR 5.6e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5BPYA Q06187 396 657 659.0 4UQ:64000 Type1 Inactive DFGin 6.3602 13.3055 BLBplus -124.65, 164.88 51.29, 37.75 -70.0, 127.36 35.13, 98.17 69.78, 12.96 out-out out 15.0418 Saltbr-out 16.1326 HRD-in -71.75, -58.49 82.06, -15.91 out-out-out SNCooo out-out ActLoopNT-out 7.8951 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.29, -6.51 APE9-dihe-in -62.22, 139.35 APE8-dihe-in -81.26, 69.56 APE8-rot-na 30.14 APE67-dihe-in -66.47, -13.16 -61.31, -41.9 APE12-dist-na 17.2653 APE11-dist-na 19.274 APE10-dist-na 14.23 APE9-dist-out 8.7636 None None None XRAY 2.31 0.215 0.242 A 267.0 262.0 0 29 29 0 [[402, 653]] 1.0 5bpy Homo sapiens TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5BPYB Q06187 396 657 659.0 4UQ:64000 Type1 Inactive DFGin 6.0407 13.3553 BLBplus -124.21, 164.45 49.48, 38.96 -70.05, 125.98 33.54, 98.82 68.93, 10.8 out-none out 14.6981 Saltbr-none 999.0 HRD-in -73.63, -56.78 81.23, -14.54 none-out-out SNCnoo out-out ActLoopNT-out 7.9375 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -33.35 APE9-dihe-out -59.81, -45.04 APE8-dihe-out -62.46, 0.27 APE8-rot-na 341.31 APE67-dihe-in -65.96, -13.01 -56.63, -35.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.1618 APE9-dist-out 11.0675 None None None XRAY 2.31 0.215 0.242 B 267.0 246.0 16 29 18 11 [[402, 653]] 1.0 5bpy Homo sapiens TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5JRSA Q06187 396 656 659.0 6MV:64000 Type1 Inactive DFGin 6.0609 13.3395 BLBplus -124.69, 170.12 55.97, 34.2 -67.63, 128.46 35.86, 96.69 69.73, 6.07 out-out out 14.9306 Saltbr-out 13.2279 HRD-in -69.99, -56.03 84.33, -14.06 out-out-out SNCooo out-out ActLoopNT-out 7.7446 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.56, 5.66 APE9-dihe-in -66.64, 144.44 APE8-dihe-in -83.22, 65.57 APE8-rot-na 33.78 APE67-dihe-in -68.72, -13.46 -60.6, -36.2 APE12-dist-na 17.2392 APE11-dist-na 19.1688 APE10-dist-na 14.3888 APE9-dist-out 8.7529 None None None XRAY 1.97 0.203 0.226 A 267.0 257.0 4 29 29 0 [[402, 653]] 1.0 5jrs Homo sapiens TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5JRSB Q06187 396 655 659.0 6MV:64000 Type1 Inactive DFGin 5.9654 13.4845 BLBplus -124.08, 170.99 56.24, 32.66 -67.77, 127.61 36.28, 96.89 68.67, 6.72 out-none out 14.8868 Saltbr-none 999.0 HRD-in -69.59, -54.99 82.87, -12.35 none-out-out SNCnoo out-out ActLoopNT-out 7.8699 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -43.7 APE9-dihe-out -53.67, -38.72 APE8-dihe-out -66.14, 0.13 APE8-rot-na 344.61 APE67-dihe-in -68.32, -13.38 -53.75, -36.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 17.8185 APE9-dist-out 11.039 None None None XRAY 1.97 0.203 0.226 B 267.0 239.0 21 29 18 11 [[402, 653]] 1.0 5jrs Homo sapiens TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5T18A Q06187 396 658 659.0 73T:60701 Type1 Inactive DFGin 6.0396 13.7879 BLBplus -128.43, 165.54 60.99, 25.86 -63.42, 127.88 36.69, 97.91 80.59, -10.26 out-out out 14.9141 Saltbr-out 15.5279 HRD-in -71.94, -54.27 84.17, -17.74 out-out-out SNCooo out-out ActLoopNT-out 7.7017 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -113.6, 4.76 APE9-dihe-in -68.35, 140.21 APE8-dihe-in -81.87, 60.04 APE8-rot-na 32.7 APE67-dihe-in -71.98, -10.48 -52.94, -39.23 APE12-dist-na 17.4513 APE11-dist-na 18.9457 APE10-dist-na 13.9709 APE9-dist-out 9.2696 None None None XRAY 1.5 0.204 0.223 A 267.0 259.0 4 29 29 0 [[402, 653]] 1.0 5t18 Homo sapiens TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7KXNA Q06187 394 659 659.0 X9P:701 Type1 Inactive DFGin 6.3685 13.7083 BLBplus -122.57, 148.94 62.24, 33.0 -62.58, 131.94 36.11, 94.82 84.8, -17.54 out-out out 14.3666 Saltbr-out 15.1599 HRD-in -72.47, -54.42 85.13, -15.06 out-out-out SNCooo out-out ActLoopNT-out 7.9007 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -108.58, 2.74 APE9-dihe-in -69.58, 141.22 APE8-dihe-in -79.75, 64.14 APE8-rot-na 28.99 APE67-dihe-in -72.75, -5.53 -54.22, -44.59 APE12-dist-na 17.4074 APE11-dist-na 18.9131 APE10-dist-na 13.9573 APE9-dist-out 8.6741 None None None XRAY 1.34 0.167 0.197 A 267.0 266.0 0 29 29 0 [[402, 653]] 1.0 7kxn Homo sapiens TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7KXOA Q06187 395 659 659.0 X9S:701 Type1 Inactive DFGin 6.3799 13.7442 BLBplus -120.11, 148.11 62.72, 27.77 -59.03, 136.32 33.69, 94.97 76.45, -12.5 out-out out 14.4052 Saltbr-out 15.3218 HRD-in -75.54, -53.57 78.37, -10.38 out-out-out SNCooo out-out ActLoopNT-out 7.8705 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -108.02, -0.92 APE9-dihe-in -67.7, 140.58 APE8-dihe-in -76.71, 60.46 APE8-rot-na 27.44 APE67-dihe-in -76.26, -4.56 -54.52, -42.77 APE12-dist-na 17.3677 APE11-dist-na 18.7268 APE10-dist-na 13.7872 APE9-dist-out 8.4989 None None None XRAY 1.94 0.205 0.248 A 267.0 265.0 0 29 29 0 [[402, 653]] 1.0 7kxo Homo sapiens TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7LTYA Q06187 393 658 659.0 YD7:701 Type1 Inactive DFGin 6.0398 13.8841 BLBplus -120.46, 149.15 59.16, 35.87 -61.84, 129.93 32.98, 96.93 84.41, -11.31 out-out out 14.4917 Saltbr-out 15.1964 HRD-in -69.98, -53.95 85.82, -17.9 out-out-out SNCooo out-out ActLoopNT-out 8.131 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.14 APE8-dihe-in -80.21, 65.2 APE8-rot-na 34.31 APE67-dihe-in -75.46, -7.66 -50.97, -45.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0195 None None None XRAY 1.69 0.179 0.208 A 267.0 255.0 11 29 18 11 [[402, 653]] 1.0 7lty Homo sapiens TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7LTZA Q06187 394 658 659.0 YDA:701 Type1 Inactive DFGin 6.4478 13.6817 BLBplus -121.71, 151.81 61.43, 29.86 -61.8, 132.15 35.67, 95.63 82.97, -15.81 out-out out 14.383 Saltbr-out 14.8545 HRD-in -72.37, -53.05 82.26, -9.58 out-out-out SNCooo out-out ActLoopNT-out 7.9097 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -106.64, -0.65 APE9-dihe-in -68.21, 140.78 APE8-dihe-in -77.46, 63.64 APE8-rot-na 28.65 APE67-dihe-in -71.62, -8.73 -54.28, -47.48 APE12-dist-na 17.493 APE11-dist-na 18.8132 APE10-dist-na 13.7376 APE9-dist-out 8.5926 None None None XRAY 1.53 0.181 0.213 A 267.0 265.0 0 29 29 0 [[402, 653]] 1.0 7ltz Homo sapiens TYR_BTK_HUMAN TYR 5.7e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7KXLA Q06187 392 658 659.0 X9J:701 Type1 Inactive DFGin 6.0553 13.81 BLBplus -115.19, 156.74 57.55, 31.61 -63.72, 128.43 43.5, 92.5 74.31, -4.58 out-out out 14.3879 Saltbr-out 14.9167 HRD-in -74.96, -55.95 81.49, -10.63 out-out-out SNCooo out-out ActLoopNT-out 7.9012 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.76, -4.08 APE9-dihe-in -65.01, 139.63 APE8-dihe-in -78.45, 60.79 APE8-rot-na 30.76 APE67-dihe-in -67.47, -10.24 -48.14, -50.89 APE12-dist-na 17.4726 APE11-dist-na 18.8749 APE10-dist-na 13.8193 APE9-dist-out 8.4261 None None None XRAY 1.84 0.2 0.229 A 268.0 267.0 0 29 29 0 [[402, 653]] 1.0 7kxl Homo sapiens TYR_BTK_HUMAN TYR 5.8e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5ZZ4A Q06187 395 655 659.0 9M3:701 Type1 Inactive DFGin 6.216 13.9816 BLBplus -111.98, 145.41 64.78, 44.4 -74.28, 132.13 32.68, 105.17 78.32, -10.69 out-none out 16.4373 Saltbr-none 999.0 HRD-in -67.71, -61.96 75.17, -0.36 none-out-out SNCnoo out-out ActLoopNT-out 7.2672 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -92.49, -1.0 APE9-dihe-in -77.31, 154.21 APE8-dihe-in -78.66, 60.05 APE8-rot-na 35.97 APE67-dihe-in -57.31, -13.94 -55.76, -59.34 APE12-dist-na 17.6748 APE11-dist-na 19.2789 APE10-dist-na 14.3435 APE9-dist-out 8.53 None None None XRAY 2.9 0.227 0.317 A 268.0 261.0 0 29 29 0 [[402, 653]] 1.0 5zz4 Homo sapiens TYR_BTK_HUMAN TYR 5.8e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5ZZ4B Q06187 393 655 659.0 9M3:701 Type1 Inactive DFGin 6.3634 14.2651 BLBplus -109.91, 138.99 65.73, 42.72 -63.28, 144.19 29.05, 106.93 50.75, 21.21 out-out out 17.3213 Saltbr-out 17.0637 HRD-in -73.01, -58.9 82.89, -15.47 out-out-out SNCooo out-out ActLoopNT-out 7.3802 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -97.75, -7.06 APE9-dihe-in -70.79, 144.21 APE8-dihe-in -75.36, 52.84 APE8-rot-na 31.73 APE67-dihe-in -64.34, -20.03 -47.19, -52.63 APE12-dist-na 17.8007 APE11-dist-na 19.0818 APE10-dist-na 14.1976 APE9-dist-out 8.5838 None None None XRAY 2.9 0.227 0.317 B 268.0 263.0 0 29 29 0 [[402, 653]] 1.0 5zz4 Homo sapiens TYR_BTK_HUMAN TYR 5.8e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5ZZ4C Q06187 394 655 659.0 9M3:701 Type1 Inactive DFGin 6.2805 14.0992 BLBplus -104.98, 150.07 61.01, 37.07 -61.77, 143.5 31.71, 121.26 50.22, 21.27 out-none out 17.295 Saltbr-none 999.0 HRD-in -60.21, -60.2 78.75, -7.3 none-out-out SNCnoo out-out ActLoopNT-out 7.264 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -87.41, -7.6 APE9-dihe-in -66.98, 152.21 APE8-dihe-in -84.69, 62.42 APE8-rot-na 38.55 APE67-dihe-in -56.47, -17.05 -55.47, -54.33 APE12-dist-na 17.8283 APE11-dist-na 19.1946 APE10-dist-na 14.3144 APE9-dist-out 8.744 None None None XRAY 2.9 0.227 0.317 C 268.0 262.0 0 29 29 0 [[402, 653]] 1.0 5zz4 Homo sapiens TYR_BTK_HUMAN TYR 5.8e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5ZZ4D Q06187 393 655 659.0 9M3:701 Type1 Inactive DFGin 6.4453 14.1097 BLBplus -100.32, 149.86 51.9, 44.48 -65.1, 145.39 31.68, 111.22 66.68, 4.44 out-none out 16.7285 Saltbr-none 999.0 HRD-in -71.61, -60.83 82.15, -8.13 none-out-out SNCnoo out-out ActLoopNT-out 7.5175 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -121.96, -10.28 APE9-dihe-in -74.58, 151.07 APE8-dihe-in -81.06, 54.54 APE8-rot-na 34.38 APE67-dihe-in -63.51, -13.9 -54.63, -46.8 APE12-dist-na 17.6647 APE11-dist-na 19.5409 APE10-dist-na 14.4737 APE9-dist-out 8.6596 None None None XRAY 2.9 0.227 0.317 D 268.0 263.0 0 29 29 0 [[402, 653]] 1.0 5zz4 Homo sapiens TYR_BTK_HUMAN TYR 5.8e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5ZZ4E Q06187 394 655 659.0 9M3:701 Type1 Inactive DFGin 6.3694 14.1758 BLBplus -106.76, 160.23 63.16, 34.1 -66.11, 143.33 39.49, 104.71 65.03, 2.18 out-out out 16.8801 Saltbr-out 13.6071 HRD-in -60.44, -55.43 77.7, -19.27 out-out-out SNCooo out-out ActLoopNT-out 7.2255 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -89.94, -8.41 APE9-dihe-in -70.93, 148.48 APE8-dihe-in -79.4, 54.28 APE8-rot-na 35.37 APE67-dihe-in -59.43, -11.62 -47.13, -55.11 APE12-dist-na 17.7365 APE11-dist-na 19.4324 APE10-dist-na 14.3472 APE9-dist-out 8.8482 None None None XRAY 2.9 0.227 0.317 E 268.0 262.0 0 29 29 0 [[402, 653]] 1.0 5zz4 Homo sapiens TYR_BTK_HUMAN TYR 5.8e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5ZZ4F Q06187 393 655 659.0 9M3:701 Type1 Inactive DFGin 6.5852 13.8504 BLBplus -109.5, 156.48 68.48, 31.68 -62.49, 139.7 30.55, 118.72 67.4, 2.97 out-none out 16.676 Saltbr-none 999.0 HRD-in -67.31, -62.62 74.22, 1.9 none-out-out SNCnoo out-out ActLoopNT-out 7.3474 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.02, 7.66 APE9-dihe-in -87.4, 149.21 APE8-dihe-in -71.07, 57.28 APE8-rot-na 25.91 APE67-dihe-in -61.15, -9.98 -57.23, -56.36 APE12-dist-na 17.4812 APE11-dist-na 19.2176 APE10-dist-na 14.2372 APE9-dist-out 8.5921 None None None XRAY 2.9 0.227 0.317 F 268.0 263.0 0 29 29 0 [[402, 653]] 1.0 5zz4 Homo sapiens TYR_BTK_HUMAN TYR 5.8e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6O8IA Q06187 391 658 659.0 LTJ:4000 Type1 Inactive DFGin 5.5354 14.972 BLBplus -129.8, -155.21 58.3, 44.54 -137.09, 133.38 65.53, 96.57 62.04, -135.93 out-out out 11.7759 Saltbr-out 14.169 HRD-in -73.8, -50.46 77.78, -9.81 out-out-out SNCooo out-out ActLoopNT-out 11.6693 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -85.73, 87.18 APE9-dihe-in -85.79, 141.41 APE8-dihe-in -78.4, 64.22 APE8-rot-na 30.1 APE67-dihe-in -70.0, -10.62 -49.55, -46.25 APE12-dist-na 16.2014 APE11-dist-na 19.9778 APE10-dist-na 18.3131 APE9-dist-out 8.2749 None None None XRAY 1.42 0.195 0.222 A 269.0 260.0 8 29 29 0 [[402, 653]] 1.0 6o8i Homo sapiens TYR_BTK_HUMAN TYR 5.9e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7N4QA Q06187 392 658 659.0 0B9:701 Type1 Inactive DFGin 6.3971 14.1185 BLBplus -122.39, 161.75 60.23, 32.62 -65.83, 123.81 35.6, 99.1 82.08, -3.68 out-out out 14.9072 Saltbr-out 15.0285 HRD-in -69.31, -52.59 79.69, -10.12 out-out-out SNCooo out-out ActLoopNT-out 8.1292 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -122.02, 17.35 APE9-dihe-in -74.51, 145.27 APE8-dihe-in -76.82, 64.99 APE8-rot-na 26.09 APE67-dihe-in -72.23, -8.19 -50.78, -45.54 APE12-dist-na 16.7811 APE11-dist-na 18.9095 APE10-dist-na 14.1374 APE9-dist-out 8.7807 None None None XRAY 1.5 0.19 0.22 A 269.0 260.0 7 29 22 7 [[402, 653]] 1.0 7n4q Homo sapiens TYR_BTK_HUMAN TYR 5.9e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7N4RA Q06187 393 658 659.0 0BG:701 Type1 Inactive DFGin 6.6442 13.591 BLBplus -121.88, 151.91 59.51, 33.13 -66.38, 128.39 34.2, 97.49 85.55, -12.93 out-out out 14.6027 Saltbr-out 14.5917 HRD-in -66.86, -50.22 79.11, -13.03 out-out-out SNCooo out-out ActLoopNT-out 8.1255 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 9.87 APE9-dihe-in -72.51, 150.22 APE8-dihe-in -80.29, 61.71 APE8-rot-na 33.0 APE67-dihe-in -75.91, -4.86 -49.09, -45.45 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.9207 APE9-dist-out 8.5637 None None None XRAY 1.62 0.194 0.222 A 269.0 257.0 9 29 20 9 [[402, 653]] 1.0 7n4r Homo sapiens TYR_BTK_HUMAN TYR 5.9e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7N4SA Q06187 394 658 659.0 0B0:701 Type1 Inactive DFGin 5.8001 13.9364 BLBplus -122.05, 156.1 62.66, 32.76 -66.63, 129.34 36.7, 93.58 75.05, 4.48 out-out out 15.3953 Saltbr-out 15.6555 HRD-in -79.25, -45.64 74.9, -11.58 out-out-out SNCooo out-out ActLoopNT-out 8.105 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.81, 4.43 APE9-dihe-in -71.06, 136.98 APE8-dihe-in -70.71, 71.79 APE8-rot-na 16.05 APE67-dihe-in -70.12, -9.25 -59.1, -43.07 APE12-dist-na 999.0 APE11-dist-na 18.2877 APE10-dist-na 13.6886 APE9-dist-out 8.5751 None None None XRAY 2.05 0.245 0.276 A 269.0 257.0 8 29 21 8 [[402, 653]] 1.0 7n4s Homo sapiens TYR_BTK_HUMAN TYR 5.9e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 4RX5A Q06187 394 657 659.0 3YO:60706 Type1 Inactive DFGin 6.1509 13.7538 BLBplus -119.61, 155.3 63.7, 23.65 -58.56, 129.53 37.72, 94.55 82.48, -13.46 out-out out 16.0169 Saltbr-out 16.2541 HRD-in -71.68, -55.75 80.97, -13.81 out-out-out SNCooo out-out ActLoopNT-out 7.5177 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.63, -6.43 APE9-dihe-in -63.26, 139.9 APE8-dihe-in -79.02, 60.45 APE8-rot-na 28.53 APE67-dihe-in -70.61, -10.64 -53.72, -41.1 APE12-dist-na 17.6828 APE11-dist-na 19.4317 APE10-dist-na 14.1078 APE9-dist-out 8.6708 None None None XRAY 1.356 0.161 0.179 A 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 4rx5 Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5KUPA Q06187 394 657 659.0 6XL:60706 Type1 Inactive DFGin 6.2956 13.7472 BLBplus -121.84, 153.05 63.8, 26.94 -58.44, 133.71 38.07, 94.47 79.47, -12.97 out-out out 16.2267 Saltbr-out 16.085 HRD-in -69.81, -54.6 79.56, -14.26 out-out-out SNCooo out-out ActLoopNT-out 7.6659 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.61, -4.77 APE9-dihe-in -65.98, 139.47 APE8-dihe-in -77.7, 59.33 APE8-rot-na 29.77 APE67-dihe-in -70.19, -9.37 -54.33, -41.62 APE12-dist-na 17.7421 APE11-dist-na 19.533 APE10-dist-na 14.1705 APE9-dist-out 8.7926 None None None XRAY 1.389 0.166 0.177 A 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 5kup Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5VGOA Q06187 394 657 659.0 9B1:60707 Type1 Inactive DFGin 6.2976 13.7236 BLBplus -124.76, 153.57 59.44, 28.24 -58.41, 134.91 40.66, 94.7 81.7, -15.25 out-out out 16.2462 Saltbr-out 16.3337 HRD-in -75.44, -56.53 79.92, -9.42 out-out-out SNCooo out-out ActLoopNT-out 7.6431 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -105.93, -6.17 APE9-dihe-in -64.13, 137.95 APE8-dihe-in -77.1, 60.07 APE8-rot-na 30.41 APE67-dihe-in -71.15, -9.42 -53.89, -41.55 APE12-dist-na 17.6088 APE11-dist-na 19.3082 APE10-dist-na 14.0442 APE9-dist-out 8.6423 None None None XRAY 1.621 0.162 0.184 A 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 5vgo Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7KXQA Q06187 390 659 659.0 X9Y:703 Type1 Inactive DFGin 6.2549 13.7675 BLBplus -126.01, 147.88 61.52, 30.89 -60.2, 130.5 35.64, 94.85 85.11, -16.52 out-out out 14.2933 Saltbr-out 14.8214 HRD-in -75.06, -57.63 85.91, -13.2 out-out-out SNCooo out-out ActLoopNT-out 7.8389 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.85, 1.09 APE9-dihe-in -69.41, 138.95 APE8-dihe-in -78.42, 60.95 APE8-rot-na 30.16 APE67-dihe-in -73.09, -6.69 -50.35, -45.55 APE12-dist-na 17.3268 APE11-dist-na 18.7507 APE10-dist-na 13.7945 APE9-dist-out 8.458 None None None XRAY 1.38 0.154 0.182 A 270.0 270.0 0 29 29 0 [[402, 653]] 1.0 7kxq Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 3OCSA Q06187 395 656 659.0 746:60999 Type1 Inactive DFGin 6.2221 13.6312 BLBplus -114.93, 147.94 62.96, 29.79 -55.44, 130.74 36.97, 95.37 87.07, -21.36 out-none out 16.4267 Saltbr-none 999.0 HRD-in -76.09, -57.01 85.33, -17.49 none-out-out SNCnoo out-out ActLoopNT-out 7.6466 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.37, -6.26 APE9-dihe-in -68.03, 138.81 APE8-dihe-in -76.92, 61.1 APE8-rot-na 27.82 APE67-dihe-in -69.57, -9.84 -52.96, -47.05 APE12-dist-na 17.4303 APE11-dist-na 19.0778 APE10-dist-na 13.7719 APE9-dist-out 8.4504 None None None XRAY 1.8 0.184 0.213 A 271.0 262.0 0 29 29 0 [[402, 653]] 1.0 3ocs Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 4OTFA Q06187 396 657 659.0 2VL:60704 Type1 Inactive DFGin 6.1809 13.7558 BLBplus -118.16, 151.16 61.72, 28.57 -55.11, 129.8 38.1, 96.01 83.0, -13.47 out-out out 16.4557 Saltbr-out 16.2069 HRD-in -75.92, -56.91 83.51, -16.44 out-out-out SNCooo out-out ActLoopNT-out 7.7345 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.77, -4.68 APE9-dihe-in -64.45, 137.09 APE8-dihe-in -77.9, 61.16 APE8-rot-na 31.4 APE67-dihe-in -69.89, -12.66 -52.32, -42.22 APE12-dist-na 17.474 APE11-dist-na 19.1296 APE10-dist-na 13.8482 APE9-dist-out 8.5545 None None OCS481 XRAY 1.95 0.167 0.203 A 271.0 262.0 0 29 29 0 [[402, 653]] 1.0 4otf Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 4ZLYA Q06187 389 658 659.0 4RU:705 Type1 Inactive DFGin 5.9412 13.5981 BLBplus -121.18, 160.02 59.56, 31.08 -62.35, 130.02 31.68, 94.98 79.06, -10.8 out-out out 14.6598 Saltbr-out 14.8697 HRD-in -71.97, -48.27 77.4, -11.56 out-out-out SNCooo out-out ActLoopNT-out 8.1494 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -118.15, 9.43 APE9-dihe-in -68.3, 142.82 APE8-dihe-in -77.25, 62.27 APE8-rot-na 27.81 APE67-dihe-in -73.91, -8.89 -51.8, -41.84 APE12-dist-na 17.2087 APE11-dist-na 19.1134 APE10-dist-na 14.2942 APE9-dist-out 9.0104 None None None XRAY 1.65 0.165 0.197 A 270.0 270.0 0 29 29 0 [[402, 653]] 1.0 4zly Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 4ZLZA Q06187 389 658 659.0 4RV:705 Type1 Inactive DFGin 6.2531 13.2938 BLBplus -122.49, 170.08 52.61, 30.14 -62.21, 131.07 34.71, 101.16 74.57, -3.58 out-out out 14.459 Saltbr-out 14.9983 HRD-in -65.3, -50.04 78.77, -11.8 out-out-out SNCooo out-out ActLoopNT-out 8.0339 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -112.73, 3.53 APE9-dihe-in -65.61, 144.48 APE8-dihe-in -79.64, 61.07 APE8-rot-na 29.52 APE67-dihe-in -68.16, -13.9 -50.41, -45.39 APE12-dist-na 17.2074 APE11-dist-na 19.0726 APE10-dist-na 14.1434 APE9-dist-out 9.0698 None None None XRAY 2.0 0.179 0.241 A 270.0 270.0 0 29 29 0 [[402, 653]] 1.0 4zlz Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 8GC7A Q06187 389 658 659.0 YXJ:701 Type1 Inactive DFGin 5.6598 13.9628 BLBplus -123.08, 158.81 53.31, 37.71 -60.57, 129.19 31.38, 95.07 80.32, -8.0 out-out out 14.8859 Saltbr-out 15.5036 HRD-in -76.19, -49.65 80.71, -9.04 out-out-out SNCooo out-out ActLoopNT-out 8.2683 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -113.49, 3.29 APE9-dihe-in -66.04, 143.07 APE8-dihe-in -74.0, 58.89 APE8-rot-na 25.36 APE67-dihe-in -71.36, -7.54 -54.52, -45.09 APE12-dist-na 17.2668 APE11-dist-na 18.8132 APE10-dist-na 13.9629 APE9-dist-out 8.7982 None None None XRAY 1.9 0.195 0.227 A 270.0 270.0 0 29 29 0 [[402, 653]] 1.0 8gc7 Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 8U2DA Q06187 389 658 659.0 UQX:701 Type1 Inactive DFGin 7.1017 13.2298 BLBplus -128.23, 153.12 56.97, 29.42 -62.44, 128.51 31.85, 99.81 83.8, -5.53 out-out out 14.7563 Saltbr-out 15.0744 HRD-in -72.87, -50.82 82.88, -13.96 out-out-out SNCooo out-out ActLoopNT-out 8.0979 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -113.19, 3.51 APE9-dihe-in -71.67, 146.89 APE8-dihe-in -77.7, 65.34 APE8-rot-na 28.87 APE67-dihe-in -74.92, -7.55 -56.99, -42.42 APE12-dist-na 16.9189 APE11-dist-na 18.7168 APE10-dist-na 13.7531 APE9-dist-out 8.5231 None None None XRAY 1.95 0.193 0.238 A 270.0 270.0 0 29 29 0 [[402, 653]] 1.0 8u2d Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 8U2EA Q06187 389 658 659.0 UP9:701 Type1 Inactive DFGin 6.0351 13.7892 BLBplus -127.58, 160.55 59.05, 29.98 -57.52, 130.4 29.31, 94.56 75.81, -4.4 out-out out 14.7822 Saltbr-out 15.5044 HRD-in -77.1, -53.33 80.92, -10.78 out-out-out SNCooo out-out ActLoopNT-out 8.1939 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -112.67, -1.09 APE9-dihe-in -65.62, 144.23 APE8-dihe-in -80.07, 66.77 APE8-rot-na 30.11 APE67-dihe-in -75.14, -6.63 -56.97, -42.88 APE12-dist-na 17.3026 APE11-dist-na 18.8593 APE10-dist-na 13.7868 APE9-dist-out 8.6931 None None None XRAY 1.9 0.193 0.238 A 270.0 270.0 0 29 29 0 [[402, 653]] 1.0 8u2e Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5U9DA Q06187 389 659 659.0 83P:701 Type1 Inactive DFGin 6.7004 13.116 BLBplus -123.64, 150.09 55.97, 32.63 -63.54, 131.47 34.45, 103.74 78.09, -3.54 out-out out 14.2631 Saltbr-out 14.8107 HRD-in -67.17, -50.39 78.01, -10.04 out-out-out SNCooo out-out ActLoopNT-out 8.1234 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.17, 9.75 APE9-dihe-in -69.32, 141.87 APE8-dihe-in -78.71, 66.26 APE8-rot-na 32.23 APE67-dihe-in -72.99, -7.55 -56.98, -43.33 APE12-dist-na 16.7205 APE11-dist-na 18.5344 APE10-dist-na 13.6493 APE9-dist-out 8.556 None None None XRAY 1.33 0.151 0.178 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 5u9d Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5VFIA Q06187 389 659 659.0 9AJ:701 Type1 Inactive DFGin 6.5486 13.7613 BLBplus -143.36, 153.96 60.49, 23.59 -61.26, 135.3 42.85, 92.4 77.99, -13.58 out-out out 14.4232 Saltbr-out 14.9707 HRD-in -71.46, -59.58 77.98, -9.84 out-out-out SNCooo out-out ActLoopNT-out 7.9475 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -110.2, -1.65 APE9-dihe-in -67.19, 139.63 APE8-dihe-in -76.43, 58.0 APE8-rot-na 29.74 APE67-dihe-in -70.96, -8.66 -49.99, -48.99 APE12-dist-na 17.2786 APE11-dist-na 18.5334 APE10-dist-na 13.6333 APE9-dist-out 8.36 None None None XRAY 1.59 0.189 0.216 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 5vfi Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6DI0A Q06187 389 659 659.0 GJG:701 Type1 Inactive DFGin 6.001 13.4805 BLBplus -124.53, 155.05 55.99, 32.11 -59.72, 127.96 33.47, 95.09 76.24, -5.83 out-out out 14.5371 Saltbr-out 14.8977 HRD-in -71.27, -49.47 78.19, -10.98 out-out-out SNCooo out-out ActLoopNT-out 8.1761 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -120.35, 18.42 APE9-dihe-in -71.2, 144.69 APE8-dihe-in -78.31, 63.76 APE8-rot-na 23.97 APE67-dihe-in -70.97, -7.34 -53.14, -44.3 APE12-dist-na 17.0042 APE11-dist-na 19.0119 APE10-dist-na 14.4067 APE9-dist-out 8.9062 None None None XRAY 1.3 0.18 0.202 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 6di0 Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6DI1A Q06187 389 659 659.0 GJD:701 Type1 Inactive DFGin 6.2305 13.4862 BLBplus -129.14, 171.13 57.85, 25.92 -61.75, 129.84 37.28, 94.65 77.09, -10.81 out-out out 14.5685 Saltbr-out 14.4879 HRD-in -69.39, -51.57 79.83, -12.8 out-out-out SNCooo out-out ActLoopNT-out 8.1849 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -115.3, 12.92 APE9-dihe-in -67.7, 143.91 APE8-dihe-in -78.96, 63.72 APE8-rot-na 24.89 APE67-dihe-in -71.41, -7.04 -52.39, -43.7 APE12-dist-na 16.9326 APE11-dist-na 19.0324 APE10-dist-na 14.3263 APE9-dist-out 8.9973 None None None XRAY 1.1 0.174 0.186 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 6di1 Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6DI9A Q06187 392 659 659.0 GJJ:701 Type1 Inactive DFGin 6.1303 13.648 BLBplus -124.28, 163.6 63.95, 24.4 -60.78, 124.97 34.06, 99.32 80.75, -11.12 out-none out 14.6651 Saltbr-none 999.0 HRD-in -70.18, -51.73 78.49, -12.84 none-out-out SNCnoo out-out ActLoopNT-out 8.1927 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 21.73 APE9-dihe-in -69.29, 145.05 APE8-dihe-in -84.76, 65.19 APE8-rot-na 29.95 APE67-dihe-in -73.47, -7.76 -50.52, -43.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.8553 APE9-dist-out 8.7836 None None None XRAY 1.25 0.194 0.207 A 271.0 252.0 16 29 19 10 [[402, 653]] 1.0 6di9 Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6NFHA Q06187 389 659 659.0 KLM:701 Type1 Inactive DFGin 5.6079 13.7659 BLBplus -122.24, 167.43 56.46, 32.17 -63.92, 123.57 34.29, 93.69 76.16, -3.03 out-out out 14.414 Saltbr-out 15.0093 HRD-in -72.27, -50.37 78.42, -8.53 out-out-out SNCooo out-out ActLoopNT-out 8.2846 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -124.53, 20.7 APE9-dihe-in -70.48, 146.89 APE8-dihe-in -82.32, 66.08 APE8-rot-na 28.28 APE67-dihe-in -74.58, -9.13 -54.47, -43.06 APE12-dist-na 16.9382 APE11-dist-na 18.9631 APE10-dist-na 14.2595 APE9-dist-out 8.8859 None None None XRAY 1.4 0.16 0.205 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 6nfh Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7KXMA Q06187 389 659 659.0 X9M:701 Type1 Inactive DFGin 6.3052 13.843 BLBplus -121.85, 153.64 56.09, 34.54 -59.98, 133.3 35.17, 95.47 76.06, -13.01 out-out out 14.6261 Saltbr-out 14.8271 HRD-in -72.42, -51.07 84.95, -19.15 out-out-out SNCooo out-out ActLoopNT-out 7.9372 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -109.49, -3.77 APE9-dihe-in -64.16, 140.71 APE8-dihe-in -76.56, 62.39 APE8-rot-na 28.45 APE67-dihe-in -70.14, -7.98 -53.04, -47.05 APE12-dist-na 17.5229 APE11-dist-na 18.8636 APE10-dist-na 13.8097 APE9-dist-out 8.4939 None None None XRAY 1.33 0.203 0.247 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 7kxm Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7KXPA Q06187 389 659 659.0 X9V:701 Type1 Inactive DFGin 6.6297 13.9869 BLBplus -119.7, 149.25 58.77, 30.75 -61.21, 130.4 38.19, 97.75 88.64, -21.79 out-out out 14.8008 Saltbr-out 15.3308 HRD-in -76.62, -57.43 86.07, -11.6 out-out-out SNCooo out-out ActLoopNT-out 7.9946 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.88, 2.42 APE9-dihe-in -67.56, 139.77 APE8-dihe-in -78.6, 62.9 APE8-rot-na 31.66 APE67-dihe-in -75.97, -4.4 -55.17, -43.17 APE12-dist-na 17.8339 APE11-dist-na 19.0914 APE10-dist-na 14.0948 APE9-dist-out 8.693 None None None XRAY 1.83 0.177 0.215 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 7kxp Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 3PIXA Q06187 391 658 659.0 027:1 Type1 Inactive DFGin 5.3666 15.249 BLBplus -130.02, -152.34 55.93, 45.93 -136.81, 147.54 66.75, 93.53 55.33, -135.04 out-out out 12.0196 Saltbr-out 13.9583 HRD-in -74.08, -51.7 83.0, -20.73 out-out-out SNCooo out-out ActLoopNT-out 11.5369 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -88.13, 91.42 APE9-dihe-in -86.77, 138.09 APE8-dihe-in -74.57, 63.36 APE8-rot-na 25.87 APE67-dihe-in -73.26, -10.96 -50.46, -44.46 APE12-dist-na 16.7616 APE11-dist-na 19.9367 APE10-dist-na 18.4933 APE9-dist-out 8.2339 None None None XRAY 1.85 0.229 0.266 A 274.0 268.0 0 29 29 0 [[402, 653]] 1.0 3pix Homo sapiens TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5J87A Q06187 396 658 659.0 N42:701 Type1 Inactive DFGin 6.3334 13.6498 BLBplus -123.42, 149.38 64.52, 28.82 -63.82, 130.7 36.78, 95.48 84.02, -10.49 out-out out 16.4042 Saltbr-out 14.4358 HRD-in -71.23, -53.8 79.96, -6.34 out-out-out SNCooo out-out ActLoopNT-out 7.667 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.16, -6.26 APE9-dihe-in -66.24, 144.47 APE8-dihe-in -83.41, 68.08 APE8-rot-na 29.78 APE67-dihe-in -68.04, -20.26 -62.31, -40.48 APE12-dist-na 17.3078 APE11-dist-na 18.9168 APE10-dist-na 13.8038 APE9-dist-out 8.4943 None None None XRAY 1.59 0.22 0.248 A 274.0 263.0 0 29 29 0 [[402, 653]] 1.0 5j87 Homo sapiens TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5J87B Q06187 385 658 659.0 N42:701 Type1 Inactive DFGin 6.3073 13.5658 BLBplus -116.27, 147.16 64.48, 33.44 -63.72, 133.38 37.03, 94.6 70.54, 9.28 out-out out 16.6033 Saltbr-out 18.4992 HRD-in -71.08, -49.77 81.97, -10.6 out-out-out SNCooo out-out ActLoopNT-out 7.4852 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.87, 1.28 APE9-dihe-in -69.91, 147.55 APE8-dihe-in -80.31, 62.9 APE8-rot-na 20.94 APE67-dihe-in -70.97, -11.78 -58.07, -42.19 APE12-dist-na 17.5467 APE11-dist-na 18.8381 APE10-dist-na 14.0075 APE9-dist-out 8.5454 None None None XRAY 1.59 0.22 0.248 B 274.0 274.0 0 29 29 0 [[402, 653]] 1.0 5j87 Homo sapiens TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5J87C Q06187 396 656 659.0 N42:701 Type1 Inactive DFGin 6.4048 13.5465 BLBplus -126.4, 157.43 65.83, 26.36 -68.75, 129.53 36.85, 83.12 64.87, 13.16 out-out out 14.9009 Saltbr-out 13.3145 HRD-in -69.99, -46.79 81.42, -9.8 out-out-out SNCooo out-out ActLoopNT-out 7.7099 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -109.62, 3.15 APE9-dihe-in -83.23, 132.48 APE8-dihe-in -75.66, 67.36 APE8-rot-na 16.98 APE67-dihe-in -69.08, -9.78 -57.68, -42.7 APE12-dist-na 17.6117 APE11-dist-na 18.9693 APE10-dist-na 13.9416 APE9-dist-out 8.3626 None None None XRAY 1.59 0.22 0.248 C 274.0 261.0 0 29 29 0 [[402, 653]] 1.0 5j87 Homo sapiens TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5J87D Q06187 396 658 659.0 N42:701 Type1 Inactive DFGin 6.0296 14.2516 BLBplus -123.89, 170.41 74.82, 20.6 -71.67, 132.66 44.67, 90.2 89.11, -16.56 out-out out 16.2582 Saltbr-out 13.8793 HRD-in -99.01, -51.17 80.74, -9.08 out-out-out SNCooo out-out ActLoopNT-out 7.7879 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -126.19, -24.51 APE9-dihe-in -55.82, 128.59 APE8-dihe-in -67.92, 50.84 APE8-rot-na 21.56 APE67-dihe-in -78.89, -3.66 -45.75, -40.96 APE12-dist-na 17.2101 APE11-dist-na 18.9448 APE10-dist-na 13.5524 APE9-dist-out 8.5228 None None None XRAY 1.59 0.22 0.248 D 274.0 263.0 0 29 29 0 [[402, 653]] 1.0 5j87 Homo sapiens TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6TFPA Q06187 393 658 659.0 N6Z:60702 Type1 Inactive DFGin 6.327 13.6595 BLBplus -118.44, 153.59 59.47, 29.92 -60.13, 129.75 36.78, 92.22 75.92, -11.76 out-out out 16.0171 Saltbr-out 16.6878 HRD-in -72.75, -58.51 83.1, -15.47 out-out-out SNCooo out-out ActLoopNT-out 7.6876 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.23, -2.15 APE9-dihe-in -63.02, 134.87 APE8-dihe-in -76.81, 63.19 APE8-rot-na 30.22 APE67-dihe-in -65.58, -11.41 -51.73, -47.33 APE12-dist-na 17.5277 APE11-dist-na 19.1405 APE10-dist-na 13.9471 APE9-dist-out 8.6424 None None None XRAY 2.0 0.187 0.204 A 276.0 266.0 0 29 29 0 [[402, 653]] 1.0 6tfp Homo sapiens TYR_BTK_HUMAN TYR 6.5e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6TFPB Q06187 385 658 659.0 N6Z:60701 Type1 Inactive DFGin 6.1662 13.6678 BLBplus -118.0, 154.73 59.63, 30.17 -62.33, 132.22 37.59, 92.25 73.87, -0.71 out-out out 15.8408 Saltbr-out 17.7523 HRD-in -74.6, -59.47 81.53, -13.42 out-out-out SNCooo out-out ActLoopNT-out 7.53 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.86, -1.96 APE9-dihe-in -63.72, 134.46 APE8-dihe-in -76.89, 63.04 APE8-rot-na 31.07 APE67-dihe-in -66.15, -10.82 -52.17, -45.8 APE12-dist-na 17.7066 APE11-dist-na 19.235 APE10-dist-na 14.024 APE9-dist-out 8.8483 None None None XRAY 2.0 0.187 0.204 B 276.0 274.0 0 29 29 0 [[402, 653]] 1.0 6tfp Homo sapiens TYR_BTK_HUMAN TYR 6.5e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6TFPC Q06187 394 657 659.0 N6Z:60702 Type1 Inactive DFGin 6.2006 13.7005 BLBplus -117.6, 153.94 59.07, 30.48 -61.34, 130.98 37.37, 83.09 74.02, -4.64 out-none out 16.1105 Saltbr-none 999.0 HRD-in -74.15, -57.57 80.85, -14.64 none-out-out SNCnoo out-out ActLoopNT-out 7.6494 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -105.77, -3.85 APE9-dihe-in -63.13, 135.07 APE8-dihe-in -77.67, 62.93 APE8-rot-na 30.6 APE67-dihe-in -66.7, -11.3 -51.86, -46.0 APE12-dist-na 17.5254 APE11-dist-na 19.1212 APE10-dist-na 13.9265 APE9-dist-out 8.6334 None None None XRAY 2.0 0.187 0.204 C 276.0 264.0 0 29 29 0 [[402, 653]] 1.0 6tfp Homo sapiens TYR_BTK_HUMAN TYR 6.5e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6TFPD Q06187 392 657 659.0 N6Z:60701 Type1 Inactive DFGin 6.4438 13.6643 BLBplus -117.89, 154.44 59.45, 29.6 -61.22, 132.28 38.37, 92.33 75.2, -12.98 out-none out 15.8644 Saltbr-none 999.0 HRD-in -73.87, -57.83 81.15, -12.26 none-out-out SNCnoo out-out ActLoopNT-out 7.4869 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.06, -4.9 APE9-dihe-in -61.09, 135.98 APE8-dihe-in -77.04, 64.98 APE8-rot-na 31.67 APE67-dihe-in -68.88, -9.49 -51.15, -46.71 APE12-dist-na 17.6695 APE11-dist-na 19.1253 APE10-dist-na 13.9019 APE9-dist-out 8.6191 None None None XRAY 2.0 0.187 0.204 D 276.0 266.0 0 29 29 0 [[402, 653]] 1.0 6tfp Homo sapiens TYR_BTK_HUMAN TYR 6.5e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6TFPE Q06187 394 657 659.0 N6Z:60701 Type1 Inactive DFGin 6.3443 13.7202 BLBplus -119.29, 154.3 57.93, 31.21 -61.51, 131.73 36.79, 91.21 74.06, -7.73 out-none out 16.0071 Saltbr-none 999.0 HRD-in -74.54, -59.23 82.44, -13.81 none-out-out SNCnoo out-out ActLoopNT-out 7.529 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.89, -3.77 APE9-dihe-in -61.76, 133.54 APE8-dihe-in -77.43, 62.05 APE8-rot-na 31.22 APE67-dihe-in -64.03, -12.65 -49.68, -49.32 APE12-dist-na 17.6877 APE11-dist-na 19.1528 APE10-dist-na 13.9211 APE9-dist-out 8.8674 None None None XRAY 2.0 0.187 0.204 E 276.0 264.0 0 29 29 0 [[402, 653]] 1.0 6tfp Homo sapiens TYR_BTK_HUMAN TYR 6.5e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5P9FA Q06187 394 659 659.0 2VL:701 Type1 Inactive DFGin 6.6211 13.7553 BLBplus -119.02, 151.22 61.15, 24.35 -53.19, 127.83 42.31, 92.54 85.51, -16.73 out-out out 14.4003 Saltbr-out 15.0261 HRD-in -75.39, -58.81 80.41, -9.12 out-out-out SNCooo out-out ActLoopNT-out 8.005 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.51, 4.62 APE9-dihe-in -72.87, 137.83 APE8-dihe-in -76.24, 65.65 APE8-rot-na 33.67 APE67-dihe-in -72.92, -8.6 -57.83, -44.5 APE12-dist-na 17.3063 APE11-dist-na 18.6164 APE10-dist-na 13.6802 APE9-dist-out 8.3054 None None None XRAY 1.71 0.15 0.223 A 279.0 266.0 0 29 29 0 [[402, 653]] 1.0 5p9f Homo sapiens TYR_BTK_HUMAN TYR 6.7e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5P9GA Q06187 394 658 659.0 7G6:701 Type1 Inactive DFGin 6.4719 13.8004 BLBplus -121.54, 153.43 59.66, 31.06 -64.75, 135.12 38.33, 95.17 81.68, -18.33 out-out out 14.5727 Saltbr-out 14.953 HRD-in -71.17, -55.56 80.66, -15.66 out-out-out SNCooo out-out ActLoopNT-out 7.9688 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.63, -5.03 APE9-dihe-in -65.5, 140.21 APE8-dihe-in -77.62, 62.47 APE8-rot-na 26.45 APE67-dihe-in -75.18, -9.51 -50.31, -43.78 APE12-dist-na 17.3031 APE11-dist-na 18.8532 APE10-dist-na 13.8123 APE9-dist-out 8.5895 None None None XRAY 1.75 0.179 0.213 A 279.0 265.0 0 29 29 0 [[402, 653]] 1.0 5p9g Homo sapiens TYR_BTK_HUMAN TYR 6.7e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5P9HA Q06187 395 658 659.0 7G7:701 Type1 Inactive DFGin 6.3198 13.8105 BLBplus -118.55, 159.68 43.16, 40.92 -70.17, 128.34 37.0, 93.74 78.75, -7.22 out-none out 15.1498 Saltbr-none 999.0 HRD-in -82.15, -48.19 78.47, -9.65 none-out-out SNCnoo out-out ActLoopNT-out 8.2168 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.58, -14.37 APE9-dihe-in -56.69, 135.42 APE8-dihe-in -75.24, 63.1 APE8-rot-na 30.9 APE67-dihe-in -69.63, -24.38 -50.99, -52.47 APE12-dist-na 17.4616 APE11-dist-na 18.8205 APE10-dist-na 13.5339 APE9-dist-out 8.6019 None None None XRAY 1.95 0.269 0.313 A 279.0 264.0 0 29 29 0 [[402, 653]] 1.0 5p9h Homo sapiens TYR_BTK_HUMAN TYR 6.7e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5P9KA Q06187 389 659 659.0 7G8:701 Type1 Inactive DFGin 5.9055 13.8153 BLBplus -123.17, 157.03 60.3, 30.92 -61.09, 126.3 32.87, 95.3 80.22, -7.56 out-out out 14.7026 Saltbr-out 14.3026 HRD-in -69.5, -51.33 77.8, -10.26 out-out-out SNCooo out-out ActLoopNT-out 8.2343 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -124.98, 19.37 APE9-dihe-in -73.18, 146.14 APE8-dihe-in -78.75, 62.96 APE8-rot-na 28.96 APE67-dihe-in -72.55, -8.33 -49.89, -44.34 APE12-dist-na 16.7887 APE11-dist-na 19.0498 APE10-dist-na 14.4236 APE9-dist-out 8.789 None None None XRAY 1.28 0.18 0.195 A 279.0 271.0 0 29 29 0 [[402, 653]] 1.0 5p9k Homo sapiens TYR_BTK_HUMAN TYR 6.7e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5P9LA Q06187 392 657 659.0 7G9:701 Type1 Inactive DFGin 6.0865 13.7982 BLBplus -122.11, 164.8 58.63, 30.82 -60.7, 123.17 37.36, 89.52 81.48, -10.88 out-none out 14.5981 Saltbr-none 999.0 HRD-in -66.82, -52.81 82.97, -17.59 none-out-out SNCnoo out-out ActLoopNT-out 8.2767 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 121.97 APE9-dihe-in -75.24, 140.2 APE8-dihe-in -82.91, 65.05 APE8-rot-na 32.95 APE67-dihe-in -69.39, -8.36 -46.7, -47.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.3777 APE9-dist-out 8.43 None None None XRAY 1.25 0.266 0.28 A 279.0 252.0 14 29 19 10 [[402, 653]] 1.0 5p9l Homo sapiens TYR_BTK_HUMAN TYR 6.7e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6AUAA Q06187 394 656 659.0 BXJ:60704 Type1 Inactive DFGin 6.0347 13.8462 BLBplus -113.46, 143.81 62.23, 31.25 -55.6, 131.48 39.5, 93.47 79.78, -7.69 out-out out 15.9647 Saltbr-out 16.1685 HRD-in -76.15, -57.98 83.66, -10.89 out-out-out SNCooo out-out ActLoopNT-out 7.689 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -108.59, -5.57 APE9-dihe-in -65.02, 138.16 APE8-dihe-in -78.22, 60.51 APE8-rot-na 28.78 APE67-dihe-in -70.24, -9.7 -52.84, -43.32 APE12-dist-na 17.8975 APE11-dist-na 19.5071 APE10-dist-na 14.1964 APE9-dist-out 8.6725 None None None XRAY 1.66 0.158 0.185 A 265.0 263.0 0 29 29 0 [[402, 653]] 1.0 6aua Homo sapiens TYR_BTK_HUMAN TYR 2.5e-92 314.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6NZMA Q06187 395 659 659.0 L9S:701 Type1 Inactive DFGin 6.1954 13.4061 BLBplus -127.43, 159.91 61.39, 26.55 -69.03, 132.98 44.91, 93.72 80.46, -12.65 out-none out 14.3945 Saltbr-none 999.0 HRD-in -68.73, -54.84 83.57, -10.4 none-out-out SNCnoo out-out ActLoopNT-out 8.1073 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -121.71, 16.48 APE9-dihe-in -71.64, 143.15 APE8-dihe-in -80.68, 63.75 APE8-rot-na 25.92 APE67-dihe-in -79.55, -7.2 -50.65, -39.49 APE12-dist-na 17.0531 APE11-dist-na 19.2307 APE10-dist-na 14.512 APE9-dist-out 8.7338 None None None XRAY 1.72 0.179 0.248 A 280.0 263.0 2 29 29 0 [[402, 653]] 1.0 6nzm Homo sapiens TYR_BTK_HUMAN TYR 6.8e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6NZMD Q06187 395 659 659.0 L9S:701 Type1 Inactive DFGin 6.4985 13.2753 BLBplus -122.27, 161.21 59.21, 28.98 -64.38, 134.47 41.01, 97.39 85.68, -23.76 out-none out 14.1566 Saltbr-none 999.0 HRD-in -71.79, -59.45 78.27, -11.98 none-out-out SNCnoo out-out ActLoopNT-out 8.112 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -112.69, 14.7 APE9-dihe-in -72.11, 142.63 APE8-dihe-in -71.57, 65.61 APE8-rot-na 26.12 APE67-dihe-in -72.16, -8.93 -55.34, -48.1 APE12-dist-na 17.0086 APE11-dist-na 19.3322 APE10-dist-na 14.4792 APE9-dist-out 8.5308 None None None XRAY 1.72 0.179 0.248 D 280.0 264.0 1 29 29 0 [[402, 653]] 1.0 6nzm Homo sapiens TYR_BTK_HUMAN TYR 6.8e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5BQ0A Q06187 389 659 659.0 4US:701 Type1 Inactive DFGin 5.711 14.0136 BLBplus -117.6, 165.11 53.91, 38.74 -59.87, 121.33 28.42, 97.88 75.49, -0.27 out-out out 14.9455 Saltbr-out 16.0917 HRD-in -77.3, -50.19 77.41, -8.91 out-out-out SNCooo out-out ActLoopNT-out 8.3116 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 12.37 APE9-dihe-in -68.79, 138.87 APE8-dihe-in -78.23, 64.02 APE8-rot-na 30.42 APE67-dihe-in -72.74, -6.77 -51.3, -44.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.7299 APE9-dist-out 8.6904 None None None XRAY 1.57 0.19 0.219 A 283.0 265.0 6 29 23 6 [[402, 653]] 1.0 5bq0 Homo sapiens TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 8FLHA Q06187 392 658 659.0 Y8H:703 Type1 Inactive DFGin 7.0006 13.7342 BLBplus -127.47, 151.88 58.58, 32.99 -67.63, 130.52 34.3, 97.77 79.25, -6.93 out-out out 14.6904 Saltbr-out 14.7005 HRD-in -69.17, -50.0 76.15, -10.29 out-out-out SNCooo out-out ActLoopNT-out 8.0494 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.61, 11.99 APE9-dihe-in -73.04, 144.49 APE8-dihe-in -77.86, 68.14 APE8-rot-na 28.99 APE67-dihe-in -72.4, -8.49 -56.82, -41.52 APE12-dist-na 16.7703 APE11-dist-na 18.9554 APE10-dist-na 13.9252 APE9-dist-out 8.7506 None None None XRAY 1.55 0.197 0.229 A 283.0 266.0 1 29 28 1 [[402, 653]] 1.0 8flh Homo sapiens TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 8FLVA Q06187 393 659 659.0 ZB9:701 Type1 Inactive DFGin 5.669 14.2437 BLBplus -122.23, 158.44 56.54, 34.26 -67.16, 128.51 35.91, 92.8 76.32, -0.09 out-out out 14.9439 Saltbr-out 15.2811 HRD-in -72.16, -49.95 77.25, -10.81 out-out-out SNCooo out-out ActLoopNT-out 8.151 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.66, 2.02 APE9-dihe-in -69.36, 139.1 APE8-dihe-in -76.14, 67.4 APE8-rot-na 26.98 APE67-dihe-in -72.71, -7.5 -54.62, -43.72 APE12-dist-na 16.6787 APE11-dist-na 18.3869 APE10-dist-na 13.4155 APE9-dist-out 8.5691 None None None XRAY 1.3 0.195 0.218 A 283.0 267.0 0 29 29 0 [[402, 653]] 1.0 8flv Homo sapiens TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 8TU3A Q06187 394 659 659.0 UEO:701 Type1 Inactive DFGin 5.7847 13.6177 BLBplus -118.94, 154.76 59.04, 31.29 -57.96, 130.06 31.96, 96.16 75.95, -6.59 out-out out 14.696 Saltbr-out 15.5429 HRD-in -75.98, -52.49 80.0, -9.2 out-out-out SNCooo out-out ActLoopNT-out 8.3403 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 12.55 APE9-dihe-in -80.8, 143.02 APE8-dihe-in -72.08, 65.2 APE8-rot-na 27.74 APE67-dihe-in -71.72, -7.13 -52.35, -43.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.9327 APE9-dist-out 8.3609 None None None XRAY 1.7 0.23 0.277 A 283.0 256.0 10 29 19 10 [[402, 653]] 1.0 8tu3 Homo sapiens TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 8TU4A Q06187 394 659 659.0 V72:701 Type1 Inactive DFGin 5.7649 13.7108 BLBplus -117.24, 150.52 56.84, 36.3 -61.24, 131.28 29.95, 97.51 78.97, -10.08 out-out out 14.6134 Saltbr-out 14.8418 HRD-in -73.78, -51.72 77.75, -7.8 out-out-out SNCooo out-out ActLoopNT-out 8.2634 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 15.07 APE9-dihe-in -78.81, 146.79 APE8-dihe-in -82.47, 66.86 APE8-rot-na 32.41 APE67-dihe-in -75.78, -8.88 -52.09, -40.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.931 APE9-dist-out 8.69 None None None XRAY 1.6 0.222 0.259 A 283.0 256.0 10 29 19 10 [[402, 653]] 1.0 8tu4 Homo sapiens TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 8TU5A Q06187 395 657 659.0 V7I:701 Type1 Inactive DFGin 5.6233 13.5299 BLBplus -125.91, 165.44 53.12, 36.0 -67.69, 121.08 34.15, 91.54 83.04, -3.54 out-none out 14.8728 Saltbr-none 999.0 HRD-in -74.47, -48.63 79.73, -8.49 none-out-out SNCnoo out-out ActLoopNT-out 8.1081 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.82 APE8-dihe-in -71.81, 67.92 APE8-rot-na 29.27 APE67-dihe-in -66.51, -10.87 -61.85, -41.92 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.6497 None None None XRAY 2.1 0.259 0.272 A 283.0 256.0 7 29 22 7 [[402, 653]] 1.0 8tu5 Homo sapiens TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 4Z3VA Q06187 389 659 659.0 4L6:705 Type1 Inactive DFGin 6.4376 13.3172 BLBplus -121.73, 164.54 60.71, 27.14 -64.95, 131.66 31.2, 100.94 74.09, -7.1 out-out out 14.3362 Saltbr-out 14.6407 HRD-in -70.4, -49.08 77.3, -11.43 out-out-out SNCooo out-out ActLoopNT-out 8.1113 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -114.32, 5.17 APE9-dihe-in -67.18, 142.05 APE8-dihe-in -78.94, 63.22 APE8-rot-na 30.53 APE67-dihe-in -72.22, -6.74 -50.76, -45.21 APE12-dist-na 17.2803 APE11-dist-na 18.9098 APE10-dist-na 14.1045 APE9-dist-out 8.942 None None None XRAY 1.6 0.166 0.198 A 283.0 271.0 0 29 29 0 [[402, 653]] 1.0 4z3v Homo sapiens TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7N5OA Q06187 389 658 659.0 0BQ:703 Type1 Inactive DFGin 5.8074 13.9825 BLBplus -123.29, 163.38 59.79, 31.01 -63.34, 125.86 32.98, 94.63 79.65, -4.58 out-out out 14.8608 Saltbr-out 15.1937 HRD-in -72.05, -49.82 80.66, -12.55 out-out-out SNCooo out-out ActLoopNT-out 8.2065 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -120.67, 12.19 APE9-dihe-in -72.74, 144.88 APE8-dihe-in -78.42, 64.27 APE8-rot-na 27.8 APE67-dihe-in -73.8, -6.15 -52.47, -44.34 APE12-dist-na 17.0828 APE11-dist-na 18.9824 APE10-dist-na 14.172 APE9-dist-out 8.9063 None None None XRAY 1.25 0.179 0.196 A 283.0 270.0 0 29 29 0 [[402, 653]] 1.0 7n5o Homo sapiens TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7N5RA Q06187 389 658 659.0 0UW:704 Type1 Inactive DFGin 5.8484 14.0833 BLBplus -120.44, 160.96 61.17, 29.05 -63.79, 128.58 33.86, 93.89 78.98, -6.22 out-out out 14.8311 Saltbr-out 14.6152 HRD-in -71.43, -50.09 81.43, -11.02 out-out-out SNCooo out-out ActLoopNT-out 8.2236 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -117.5, 12.88 APE9-dihe-in -70.22, 144.62 APE8-dihe-in -82.33, 64.59 APE8-rot-na 28.16 APE67-dihe-in -75.2, -6.05 -52.81, -44.49 APE12-dist-na 17.1763 APE11-dist-na 19.0205 APE10-dist-na 14.2056 APE9-dist-out 8.9693 None None None XRAY 1.55 0.172 0.195 A 283.0 270.0 0 29 29 0 [[402, 653]] 1.0 7n5r Homo sapiens TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7N5XA Q06187 389 658 659.0 0GW:705 Type1 Inactive DFGin 5.8249 14.1413 BLBplus -122.98, 162.6 61.95, 30.97 -64.19, 123.83 32.93, 94.28 81.06, -6.49 out-out out 14.9169 Saltbr-out 14.9652 HRD-in -71.63, -54.05 81.79, -7.95 out-out-out SNCooo out-out ActLoopNT-out 8.1748 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -119.58, 14.9 APE9-dihe-in -74.21, 146.6 APE8-dihe-in -81.36, 66.06 APE8-rot-na 31.26 APE67-dihe-in -73.27, -8.48 -54.05, -44.57 APE12-dist-na 17.1686 APE11-dist-na 19.0472 APE10-dist-na 14.1696 APE9-dist-out 8.8049 None None None XRAY 1.6 0.167 0.188 A 283.0 269.0 1 29 28 1 [[402, 653]] 1.0 7n5x Homo sapiens TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7N5YA Q06187 389 658 659.0 0CI:702 Type1 Inactive DFGin 5.8503 13.9269 BLBplus -119.73, 159.64 61.05, 31.21 -60.16, 124.56 30.4, 95.67 76.7, -6.8 out-out out 14.8465 Saltbr-out 14.0387 HRD-in -69.54, -53.84 78.09, -6.42 out-out-out SNCooo out-out ActLoopNT-out 8.2102 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -118.04, 12.35 APE9-dihe-in -69.71, 142.6 APE8-dihe-in -78.04, 68.29 APE8-rot-na 29.87 APE67-dihe-in -74.58, -10.82 -57.15, -42.34 APE12-dist-na 17.1239 APE11-dist-na 19.0224 APE10-dist-na 14.2529 APE9-dist-out 8.892 None None None XRAY 1.85 0.165 0.202 A 283.0 270.0 0 29 29 0 [[402, 653]] 1.0 7n5y Homo sapiens TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6BIKA Q06187 395 657 659.0 DTJ:60703 Type1 Inactive DFGin 6.3841 14.0002 BLBplus -119.8, 152.4 60.52, 28.21 -56.87, 131.18 36.5, 96.72 81.2, -12.47 out-none out 16.6842 Saltbr-none 999.0 HRD-in -74.16, -57.25 88.25, -17.53 none-out-out SNCnoo out-out ActLoopNT-out 7.6051 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.83, -2.2 APE9-dihe-in -67.83, 138.28 APE8-dihe-in -73.88, 59.52 APE8-rot-na 27.43 APE67-dihe-in -69.41, -12.39 -52.91, -44.34 APE12-dist-na 17.3939 APE11-dist-na 18.9683 APE10-dist-na 13.8335 APE9-dist-out 8.5211 None None OCS481 XRAY 1.901 0.164 0.222 A 287.0 263.0 0 29 29 0 [[402, 653]] 1.0 6bik Homo sapiens TYR_BTK_HUMAN TYR 7.5e-93 316.5 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6BKEA Q06187 395 657 659.0 DVJ:60704 Type1 Inactive DFGin 6.4876 13.9383 BLBplus -126.32, 153.83 60.67, 32.8 -70.23, 116.75 39.9, 95.03 97.51, -8.65 out-none out 16.4001 Saltbr-none 999.0 HRD-in -77.9, -59.26 85.69, -8.86 none-out-out SNCnoo out-out ActLoopNT-out 7.605 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.43, -4.68 APE9-dihe-in -63.91, 139.08 APE8-dihe-in -79.1, 67.74 APE8-rot-na 29.94 APE67-dihe-in -71.93, -10.38 -60.35, -42.97 APE12-dist-na 17.3132 APE11-dist-na 18.7054 APE10-dist-na 13.6717 APE9-dist-out 8.3796 None None OCS481 XRAY 1.95 0.195 0.21 A 287.0 263.0 0 29 29 0 [[402, 653]] 1.0 6bke Homo sapiens TYR_BTK_HUMAN TYR 7.5e-93 316.5 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6BKHA Q06187 396 657 659.0 DVD:60705 Type1 Inactive DFGin 6.1988 13.9213 BLBplus -120.76, 152.75 61.05, 28.99 -60.38, 133.58 37.31, 96.56 79.08, -14.5 out-none out 16.3231 Saltbr-none 999.0 HRD-in -71.21, -59.82 85.99, -15.66 none-out-out SNCnoo out-out ActLoopNT-out 7.4761 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -104.4, -2.91 APE9-dihe-in -63.79, 139.55 APE8-dihe-in -76.66, 61.14 APE8-rot-na 31.95 APE67-dihe-in -72.41, -9.9 -54.11, -43.03 APE12-dist-na 17.4099 APE11-dist-na 18.7351 APE10-dist-na 13.6543 APE9-dist-out 8.5138 None None OCS481 XRAY 1.792 0.155 0.201 A 287.0 262.0 0 29 29 0 [[402, 653]] 1.0 6bkh Homo sapiens TYR_BTK_HUMAN TYR 7.5e-93 316.5 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6BLNA Q06187 395 657 659.0 DY4:60704 Type1 Inactive DFGin 6.5839 13.9111 BLBplus -124.8, 153.54 63.35, 26.73 -64.52, 129.72 38.37, 96.67 86.35, -14.36 out-none out 16.3978 Saltbr-none 999.0 HRD-in -71.3, -59.79 85.0, -16.09 none-out-out SNCnoo out-out ActLoopNT-out 7.6162 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.97, -4.42 APE9-dihe-in -63.01, 141.51 APE8-dihe-in -78.86, 60.98 APE8-rot-na 31.85 APE67-dihe-in -70.4, -8.96 -53.74, -45.58 APE12-dist-na 17.3722 APE11-dist-na 18.7594 APE10-dist-na 13.7412 APE9-dist-out 8.4961 None None OCS481 XRAY 1.3 0.157 0.176 A 287.0 263.0 0 29 29 0 [[402, 653]] 1.0 6bln Homo sapiens TYR_BTK_HUMAN TYR 7.5e-93 316.5 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6XE4A Q06187 395 657 659.0 V1G:60701 Type1 Inactive DFGin 6.1943 13.6407 BLBplus -118.24, 147.72 59.06, 30.5 -55.62, 131.44 40.31, 93.31 84.57, -17.21 out-out out 16.4477 Saltbr-out 16.2729 HRD-in -71.74, -55.94 86.25, -14.57 out-out-out SNCooo out-out ActLoopNT-out 7.5294 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.94, -7.76 APE9-dihe-in -61.33, 140.85 APE8-dihe-in -79.95, 62.63 APE8-rot-na 31.88 APE67-dihe-in -68.74, -9.88 -56.03, -45.01 APE12-dist-na 17.4824 APE11-dist-na 18.9134 APE10-dist-na 13.7082 APE9-dist-out 8.5057 None None None XRAY 1.6 0.159 0.18 A 287.0 263.0 0 29 29 0 [[402, 653]] 1.0 6xe4 Homo sapiens TYR_BTK_HUMAN TYR 7.5e-93 316.5 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6VXQA Q06187 392 658 659.0 RQS:702 Type1 Inactive DFGin 5.9063 13.6898 BLBplus -122.83, 157.58 57.26, 33.98 -59.89, 127.74 30.82, 94.77 79.05, -7.39 out-out out 14.3059 Saltbr-out 14.854 HRD-in -69.21, -50.72 77.9, -12.04 out-out-out SNCooo out-out ActLoopNT-out 8.1677 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -106.85, 10.15 APE9-dihe-in -68.94, 144.76 APE8-dihe-in -79.49, 60.01 APE8-rot-na 30.12 APE67-dihe-in -70.66, -9.2 -48.35, -45.21 APE12-dist-na 999.0 APE11-dist-na 18.1042 APE10-dist-na 13.7832 APE9-dist-out 8.6338 None None None XRAY 1.4 0.186 0.224 A 293.0 258.0 9 29 20 9 [[402, 653]] 1.0 6vxq Homo sapiens TYR_BTK_HUMAN TYR 8e-93 316.4 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6W06A Q06187 393 659 659.0 S5M:1103 Type1 Inactive DFGin 6.3583 13.8219 BLBplus -123.71, 156.56 59.73, 31.74 -64.1, 135.24 36.24, 95.13 79.05, -18.5 out-out out 14.6291 Saltbr-out 15.2181 HRD-in -69.12, -54.37 83.0, -13.71 out-out-out SNCooo out-out ActLoopNT-out 7.9362 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -108.14, 1.34 APE9-dihe-in -68.88, 143.25 APE8-dihe-in -80.0, 64.87 APE8-rot-na 30.09 APE67-dihe-in -71.63, -9.29 -52.57, -44.76 APE12-dist-na 17.3783 APE11-dist-na 19.112 APE10-dist-na 14.0739 APE9-dist-out 8.6361 None None None XRAY 1.55 0.197 0.225 A 293.0 267.0 0 29 29 0 [[402, 653]] 1.0 6w06 Homo sapiens TYR_BTK_HUMAN TYR 8e-93 316.4 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6W07A Q06187 393 658 659.0 S9A:901 Type1 Inactive DFGin 5.8952 13.8117 BLBplus -121.55, 148.3 60.83, 28.42 -56.86, 131.76 40.16, 94.44 81.08, -19.73 out-out out 14.6151 Saltbr-out 15.5547 HRD-in -64.74, -55.07 81.47, -10.71 out-out-out SNCooo out-out ActLoopNT-out 7.9129 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -97.59, 1.54 APE9-dihe-in -71.47, 144.5 APE8-dihe-in -78.84, 63.09 APE8-rot-na 27.44 APE67-dihe-in -79.6, -3.04 -59.76, -38.2 APE12-dist-na 17.4025 APE11-dist-na 18.9013 APE10-dist-na 13.7933 APE9-dist-out 8.7012 None None None XRAY 1.51 0.231 0.267 A 293.0 264.0 2 29 29 0 [[402, 653]] 1.0 6w07 Homo sapiens TYR_BTK_HUMAN TYR 8e-93 316.4 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 8FLGA Q06187 395 659 659.0 Y8C:702 Type1 Inactive DFGin 5.8019 14.0811 BLBplus -120.07, 171.21 57.33, 28.78 -64.54, 135.98 37.48, 93.3 76.87, -5.06 out-out out 15.1689 Saltbr-out 14.6997 HRD-in -72.29, -50.51 73.76, -11.04 out-out-out SNCooo out-out ActLoopNT-out 8.2217 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.78, 12.49 APE9-dihe-in -73.43, 144.93 APE8-dihe-in -74.0, 67.63 APE8-rot-na 352.82 APE67-dihe-in -69.94, -9.06 -58.47, -43.92 APE12-dist-na 16.651 APE11-dist-na 18.7009 APE10-dist-na 13.8353 APE9-dist-out 8.7046 None None None XRAY 2.2 0.198 0.254 A 293.0 261.0 4 29 29 0 [[402, 653]] 1.0 8flg Homo sapiens TYR_BTK_HUMAN TYR 8e-93 316.4 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 4OT5A Q06187 396 658 659.0 481:701 Type1 Inactive DFGin 6.798 13.802 BLBplus -124.36, 153.13 64.4, 22.83 -60.17, 134.59 35.61, 95.76 78.16, -11.12 out-out out 14.3644 Saltbr-out 14.7935 HRD-in -77.95, -53.68 73.97, -6.47 out-out-out SNCooo out-out ActLoopNT-out 7.7941 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.42, 0.06 APE9-dihe-in -66.16, 143.44 APE8-dihe-in -81.04, 65.47 APE8-rot-na 30.95 APE67-dihe-in -72.59, -7.35 -55.28, -46.28 APE12-dist-na 17.5583 APE11-dist-na 19.1681 APE10-dist-na 14.0056 APE9-dist-out 8.3931 M489A,R492A,E624A,K625A None None XRAY 1.55 0.143 0.194 A 283.0 263.0 0 29 29 0 [[402, 653]] 1.0 4ot5 Homo sapiens TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 4OT6A Q06187 394 658 659.0 2V1:701 Type1 Inactive DFGin 6.4725 13.7394 BLBplus -120.83, 155.02 54.77, 30.09 -59.69, 128.73 35.37, 98.86 78.94, -1.38 out-out out 15.5686 Saltbr-out 16.2187 HRD-in -74.99, -53.47 75.85, -9.95 out-out-out SNCooo out-out ActLoopNT-out 7.9105 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -123.76, 12.12 APE9-dihe-in -69.26, 136.59 APE8-dihe-in -72.58, 60.99 APE8-rot-na 26.45 APE67-dihe-in -70.3, -14.09 -50.44, -42.82 APE12-dist-na 17.4004 APE11-dist-na 19.2434 APE10-dist-na 14.4215 APE9-dist-out 8.5641 M489A,R492A,E624A,K625A None None XRAY 2.05 0.219 0.278 A 283.0 265.0 0 29 29 0 [[402, 653]] 1.0 4ot6 Homo sapiens TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 4OTQA Q06187 396 658 659.0 2V2:701 Type1 Inactive DFGin 6.6664 13.9201 BLBplus -120.48, 151.21 61.07, 26.68 -61.61, 135.39 39.54, 95.11 81.03, -13.62 out-out out 14.3287 Saltbr-out 14.647 HRD-in -78.07, -55.02 76.57, -9.58 out-out-out SNCooo out-out ActLoopNT-out 7.6891 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -114.08, -3.11 APE9-dihe-in -65.13, 140.69 APE8-dihe-in -79.51, 63.96 APE8-rot-na 32.39 APE67-dihe-in -73.32, -5.64 -54.47, -47.5 APE12-dist-na 17.5552 APE11-dist-na 19.0077 APE10-dist-na 13.8866 APE9-dist-out 8.2582 M489A,R492A,E624A,K625A None None XRAY 1.55 0.15 0.189 A 283.0 263.0 0 29 29 0 [[402, 653]] 1.0 4otq Homo sapiens TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 4OTRA Q06187 396 658 659.0 2V3:701 Type1 Inactive DFGin 6.3496 13.7746 BLBplus -119.48, 149.94 64.46, 21.96 -55.92, 130.38 40.22, 95.71 83.39, -9.14 out-out out 15.6674 Saltbr-out 16.3264 HRD-in -80.64, -53.94 77.44, -10.65 out-out-out SNCooo out-out ActLoopNT-out 7.7294 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.0, 0.07 APE9-dihe-in -66.03, 138.84 APE8-dihe-in -74.94, 59.43 APE8-rot-na 28.29 APE67-dihe-in -69.85, -12.86 -50.01, -47.21 APE12-dist-na 17.2616 APE11-dist-na 18.998 APE10-dist-na 13.8966 APE9-dist-out 8.2156 M489A,R492A,E624A,K625A None None XRAY 1.95 0.183 0.229 A 283.0 263.0 0 29 29 0 [[402, 653]] 1.0 4otr Homo sapiens TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 4RFYA Q06187 396 658 659.0 3OU:701 Type1 Inactive DFGin 6.511 13.8944 BLBplus -125.37, 155.11 59.5, 29.61 -67.87, 135.59 36.18, 99.4 80.78, -11.15 out-out out 14.3118 Saltbr-out 14.8285 HRD-in -73.99, -53.56 68.51, -7.57 out-out-out SNCooo out-out ActLoopNT-out 7.7675 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.93, 5.87 APE9-dihe-in -70.74, 143.29 APE8-dihe-in -76.69, 63.58 APE8-rot-na 29.89 APE67-dihe-in -76.8, -9.05 -56.47, -40.03 APE12-dist-na 17.3167 APE11-dist-na 19.0599 APE10-dist-na 14.088 APE9-dist-out 8.3327 M489A,R492A,E624A,K625A None None XRAY 1.7 0.184 0.219 A 283.0 263.0 0 29 29 0 [[402, 653]] 1.0 4rfy Homo sapiens TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 4RFZA Q06187 396 658 659.0 3OV:701 Type1 Inactive DFGin 6.4738 13.8576 BLBplus -122.25, 154.4 62.29, 26.6 -61.76, 133.26 37.14, 97.18 80.17, -12.8 out-out out 14.3953 Saltbr-out 14.7442 HRD-in -73.89, -56.12 78.47, -8.51 out-out-out SNCooo out-out ActLoopNT-out 7.7796 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.55, -1.47 APE9-dihe-in -66.52, 144.01 APE8-dihe-in -81.41, 64.37 APE8-rot-na 27.37 APE67-dihe-in -73.77, -5.98 -53.3, -47.21 APE12-dist-na 17.3043 APE11-dist-na 19.0231 APE10-dist-na 14.0298 APE9-dist-out 8.2995 M489A,R492A,E624A,K625A None None XRAY 1.17 0.158 0.184 A 283.0 263.0 0 29 29 0 [[402, 653]] 1.0 4rfz Homo sapiens TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 4RG0A Q06187 396 658 659.0 3P0:701 Type1 Inactive DFGin 6.0584 13.6825 BLBplus -111.63, 164.22 48.59, 22.66 -55.13, 122.3 47.16, 92.54 89.41, -9.26 out-out out 15.7607 Saltbr-out 16.5721 HRD-in -71.22, -55.66 80.23, -5.88 out-out-out SNCooo out-out ActLoopNT-out 7.5255 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.89, 2.41 APE9-dihe-in -69.3, 136.69 APE8-dihe-in -69.65, 64.41 APE8-rot-na 23.23 APE67-dihe-in -66.68, -7.08 -59.2, -53.75 APE12-dist-na 17.4366 APE11-dist-na 19.0132 APE10-dist-na 13.8407 APE9-dist-out 8.2177 M489A,R492A,E624A,K625A None None XRAY 2.5 0.203 0.282 A 283.0 263.0 0 29 29 0 [[402, 653]] 1.0 4rg0 Homo sapiens TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6EP9A Q06187 396 658 659.0 BNB:701 Type1 Inactive DFGin 6.1666 13.9342 BLBplus -110.74, 150.79 56.23, 33.93 -61.07, 129.12 39.2, 95.59 79.19, -9.19 out-out out 14.7293 Saltbr-out 14.9123 HRD-in -77.75, -56.4 82.19, -12.26 out-out-out SNCooo out-out ActLoopNT-out 7.7856 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -106.21, 1.04 APE9-dihe-in -68.91, 137.58 APE8-dihe-in -72.36, 63.98 APE8-rot-na 26.41 APE67-dihe-in -73.5, -8.99 -57.91, -45.11 APE12-dist-na 17.7344 APE11-dist-na 19.2826 APE10-dist-na 14.1655 APE9-dist-out 8.3975 M489A,R492A,E624A,K625A None None XRAY 2.01 0.201 0.239 A 283.0 263.0 0 29 29 0 [[402, 653]] 1.0 6ep9 Homo sapiens TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6HRPA Q06187 396 658 659.0 GMQ:701 Type1 Inactive DFGin 6.7785 13.8237 BLBplus -120.01, 154.93 63.87, 24.84 -63.8, 130.04 41.5, 95.52 80.52, -10.39 out-out out 14.4441 Saltbr-out 14.7807 HRD-in -76.75, -57.42 80.54, -8.58 out-out-out SNCooo out-out ActLoopNT-out 7.6882 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.6, -4.02 APE9-dihe-in -62.76, 144.95 APE8-dihe-in -81.63, 63.16 APE8-rot-na 29.31 APE67-dihe-in -73.11, -6.75 -53.02, -46.87 APE12-dist-na 17.3398 APE11-dist-na 18.8644 APE10-dist-na 13.8258 APE9-dist-out 8.2717 M489A,R492A,E624A,K625A None None XRAY 1.12 0.175 0.192 A 283.0 263.0 0 29 29 0 [[402, 653]] 1.0 6hrp Homo sapiens TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6HRTA Q06187 396 658 659.0 GMW:701 Type1 Inactive DFGin 6.7678 13.6971 BLBplus -129.9, 157.16 58.03, 26.49 -64.79, 131.05 44.36, 88.77 85.95, -9.96 out-out out 14.4075 Saltbr-out 14.6019 HRD-in -77.59, -59.06 79.34, -5.85 out-out-out SNCooo out-out ActLoopNT-out 7.7112 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -107.93, -3.12 APE9-dihe-in -64.76, 141.34 APE8-dihe-in -77.14, 61.89 APE8-rot-na 34.59 APE67-dihe-in -73.94, -5.66 -51.96, -47.3 APE12-dist-na 17.5554 APE11-dist-na 19.0329 APE10-dist-na 14.0211 APE9-dist-out 8.3716 M489A,R492A,E624A,K625A None None XRAY 1.36 0.179 0.201 A 283.0 263.0 0 29 29 0 [[402, 653]] 1.0 6hrt Homo sapiens TYR_BTK_HUMAN TYR 1.2e-92 315.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 8GC8A Q06187 392 658 659.0 YXJ:701 Type1 Inactive DFGin 5.1834 15.1378 BLBplus -134.69, 175.7 58.6, 34.59 -69.33, 126.95 30.22, 92.4 68.12, 26.22 out-none out 10.2731 Saltbr-none 999.0 HRD-in -70.76, -51.81 78.81, -13.3 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -7.44 APE9-dihe-in -63.53, 136.38 APE8-dihe-in -74.86, 62.75 APE8-rot-na 28.86 APE67-dihe-in -70.09, -12.77 -52.21, -44.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.8226 APE9-dist-out 8.2583 L528W None None XRAY 1.75 0.197 0.223 A 270.0 253.0 14 29 15 14 [[402, 653]] 1.0 8gc8 Homo sapiens TYR_BTK_HUMAN TYR 1e-91 312.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 8EJBA Q06187 389 658 659.0 WKC:701,PD:704 Type1,Allosteric Inactive DFGin 5.8635 14.131 BLBplus -124.35, 159.5 59.65, 31.06 -60.28, 129.86 32.43, 98.92 80.65, -9.58 out-out out 15.03 Saltbr-out 15.0205 HRD-in -75.99, -52.85 80.07, -7.93 out-out-out SNCooo out-out ActLoopNT-out 8.2475 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.26, -3.27 APE9-dihe-in -67.08, 143.23 APE8-dihe-in -76.66, 62.81 APE8-rot-na 33.31 APE67-dihe-in -73.82, -6.2 -53.78, -45.31 APE12-dist-na 17.3567 APE11-dist-na 18.9197 APE10-dist-na 13.9181 APE9-dist-out 8.7469 None None None XRAY 1.58 0.169 0.191 A 270.0 270.0 0 29 29 0 [[402, 653]] 1.0 8ejb Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6X3NA Q06187 392 659 659.0 ULV:701,5WE:702 Type1,Allosteric Inactive DFGin 4.8348 13.7977 BLBplus -128.18, -176.06 44.41, 34.78 -60.88, 111.95 32.8, 95.06 63.47, 33.77 out-out out 11.6687 Saltbr-out 11.8984 HRD-in -66.13, -43.52 63.4, 23.37 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -10.53 APE9-dihe-in -64.61, 137.44 APE8-dihe-in -75.97, 67.43 APE8-rot-na 33.99 APE67-dihe-in -69.55, -8.99 -53.26, -46.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.6731 APE9-dist-in 7.8964 None None None XRAY 1.95 0.215 0.242 A 271.0 254.0 14 29 15 14 [[402, 653]] 1.0 6x3n Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6BKWA Q06187 393 657 659.0 DXM:60704,FPZ:60705 Type1,Type1 Inactive DFGin 6.1862 13.6782 BLBplus -124.67, 165.61 61.44, 24.6 -62.17, 130.9 37.63, 93.68 82.92, -15.3 out-out out 15.9212 Saltbr-out 16.2424 HRD-in -73.62, -59.24 85.68, -13.49 out-out-out SNCooo out-out ActLoopNT-out 7.602 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -105.25, -3.91 APE9-dihe-in -65.93, 143.9 APE8-dihe-in -79.36, 62.05 APE8-rot-na 31.29 APE67-dihe-in -73.0, -8.66 -54.79, -43.17 APE12-dist-na 17.3041 APE11-dist-na 18.8657 APE10-dist-na 13.7968 APE9-dist-out 8.4671 None None OCS481 XRAY 1.499 0.164 0.19 A 287.0 265.0 0 29 29 0 [[402, 653]] 1.0 6bkw Homo sapiens TYR_BTK_HUMAN TYR 7.5e-93 316.5 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6J6MA Q06187 393 659 659.0 BA0:701 Type1.5_Back Inactive DFGin 5.8121 13.0541 BLBplus -135.59, 169.19 55.61, 26.97 -64.95, 126.62 36.43, 91.43 74.18, -5.22 out-out out 14.6197 Saltbr-out 14.7674 HRD-in -71.43, -50.77 78.61, -11.37 out-out-out SNCooo out-out ActLoopNT-out 8.254 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -126.1, 23.72 APE9-dihe-in -77.33, 146.88 APE8-dihe-in -77.55, 62.03 APE8-rot-na 27.93 APE67-dihe-in -71.72, -9.7 -50.99, -43.68 APE12-dist-na 16.9263 APE11-dist-na 19.0797 APE10-dist-na 14.3364 APE9-dist-out 8.9377 None None None XRAY 1.25 0.158 0.164 A 269.0 267.0 0 29 29 0 [[402, 653]] 1.0 6j6m Homo sapiens TYR_BTK_HUMAN TYR 5.9e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7R61A Q06187 390 659 659.0 2IJ:701 Type1.5_Back Inactive DFGin 6.1667 13.5106 BLBplus -130.09, 168.71 60.32, 26.86 -63.86, 125.8 36.94, 90.04 75.65, -5.37 out-out out 14.7698 Saltbr-out 14.6152 HRD-in -71.44, -55.62 86.29, -18.58 out-out-out SNCooo out-out ActLoopNT-out 8.1523 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -114.85, 23.78 APE9-dihe-in -75.91, 149.83 APE8-dihe-in -77.54, 62.5 APE8-rot-na 24.68 APE67-dihe-in -73.5, -9.4 -54.0, -41.43 APE12-dist-na 999.0 APE11-dist-na 18.7924 APE10-dist-na 14.2029 APE9-dist-out 8.6175 None None None XRAY 1.52 0.21 0.241 A 270.0 266.0 4 29 27 2 [[402, 653]] 1.0 7r61 Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6DI3A Q06187 393 659 659.0 GJA:701 Type1.5_Back Inactive DFGin 5.8529 13.4924 BLBplus -126.21, 173.61 50.38, 39.23 -74.31, 132.3 30.93, 92.98 76.94, -5.97 out-out out 14.9262 Saltbr-out 15.0816 HRD-in -71.76, -54.07 76.6, -13.3 out-out-out SNCooo out-out ActLoopNT-out 8.1118 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -115.63, 22.9 APE9-dihe-in -80.38, 148.06 APE8-dihe-in -74.58, 62.62 APE8-rot-na 35.13 APE67-dihe-in -75.74, -14.01 -52.62, -40.19 APE12-dist-na 999.0 APE11-dist-na 19.1774 APE10-dist-na 14.2129 APE9-dist-out 8.7964 None None None XRAY 2.0 0.2 0.235 A 271.0 256.0 11 29 20 9 [[402, 653]] 1.0 6di3 Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6DI5A Q06187 389 659 659.0 GJ7:701 Type1.5_Back Inactive DFGin 6.1367 13.6489 BLBplus -124.76, 169.41 59.33, 26.21 -64.33, 120.35 41.58, 90.2 76.26, -4.53 out-out out 15.3445 Saltbr-out 15.1813 HRD-in -67.75, -53.44 78.09, -12.96 out-out-out SNCooo out-out ActLoopNT-out 8.476 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -124.36, 15.12 APE9-dihe-in -72.97, 147.27 APE8-dihe-in -78.03, 63.48 APE8-rot-na 28.51 APE67-dihe-in -70.11, -10.04 -51.62, -44.66 APE12-dist-na 17.3116 APE11-dist-na 19.4898 APE10-dist-na 14.5459 APE9-dist-out 9.0259 None None None XRAY 1.42 0.179 0.195 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 6di5 Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6N9PA Q06187 389 659 659.0 KHD:701 Type1.5_Back Inactive DFGin 6.022 13.1488 BLBplus -135.16, 168.56 61.05, 24.76 -60.32, 126.3 32.73, 92.73 82.64, -10.27 out-out out 14.884 Saltbr-out 14.4647 HRD-in -74.58, -57.02 87.46, -11.61 out-out-out SNCooo out-out ActLoopNT-out 8.2289 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -130.81, 21.92 APE9-dihe-in -81.87, 143.99 APE8-dihe-in -76.35, 61.7 APE8-rot-na 35.11 APE67-dihe-in -69.01, -14.75 -47.64, -43.95 APE12-dist-na 16.9695 APE11-dist-na 19.0983 APE10-dist-na 14.2677 APE9-dist-out 8.6791 None None None XRAY 2.23 0.18 0.24 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 6n9p Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6OMUA Q06187 389 659 659.0 MZJ:702 Type1.5_Back Inactive DFGin 5.9379 13.0956 BLBplus -133.61, 168.19 58.61, 26.15 -63.54, 125.97 38.78, 91.6 73.79, -2.97 out-out out 14.6658 Saltbr-out 14.6318 HRD-in -71.55, -50.68 78.17, -9.02 out-out-out SNCooo out-out ActLoopNT-out 8.1849 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -122.21, 19.83 APE9-dihe-in -75.51, 145.29 APE8-dihe-in -79.05, 64.22 APE8-rot-na 21.1 APE67-dihe-in -72.7, -8.26 -51.72, -43.25 APE12-dist-na 16.9433 APE11-dist-na 18.9908 APE10-dist-na 14.3602 APE9-dist-out 8.9297 None None None XRAY 1.41 0.192 0.226 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 6omu Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7L5OA Q06187 389 658 659.0 R1L:701 Type1.5_Back Inactive DFGin 5.8499 13.5104 BLBplus -127.43, 169.25 53.97, 29.73 -65.91, 123.67 36.33, 92.05 77.24, -5.04 out-out out 15.1083 Saltbr-out 16.4449 HRD-in -71.18, -52.4 80.56, -12.24 out-out-out SNCooo out-out ActLoopNT-out 8.264 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -118.38, 16.38 APE9-dihe-in -74.36, 147.1 APE8-dihe-in -80.26, 62.57 APE8-rot-na 28.52 APE67-dihe-in -70.42, -8.96 -52.75, -44.25 APE12-dist-na 16.7737 APE11-dist-na 18.8715 APE10-dist-na 14.0889 APE9-dist-out 8.8053 None None None XRAY 1.21 0.166 0.178 A 271.0 267.0 3 29 29 0 [[402, 653]] 1.0 7l5o Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7L5PA Q06187 392 659 659.0 R1L:701 Type1.5_Back Inactive DFGin 6.1034 13.0374 BLBplus -151.23, 168.83 53.15, 32.8 -79.38, 131.65 40.46, 88.14 71.41, 6.82 out-out out 15.3658 Saltbr-out 15.5545 HRD-in -68.01, -52.65 77.95, -4.37 out-out-out SNCooo out-out ActLoopNT-out 7.2856 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -109.51, 12.03 APE9-dihe-in -74.87, 144.93 APE8-dihe-in -82.28, 79.26 APE8-rot-na 33.38 APE67-dihe-in -67.12, -16.82 -64.07, -43.92 APE12-dist-na 16.6835 APE11-dist-na 18.5176 APE10-dist-na 13.7311 APE9-dist-out 8.389 None None None XRAY 2.14 0.226 0.258 A 271.0 268.0 0 29 29 0 [[402, 653]] 1.0 7l5p Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7L5PB Q06187 393 658 659.0 R1L:701 Type1.5_Back Inactive DFGin 5.7994 12.6273 BLBplus -137.35, 172.01 53.29, 29.88 -71.22, 123.27 32.45, 86.8 75.33, 2.9 out-out out 13.9887 Saltbr-out 12.1619 HRD-in -68.95, -53.54 83.16, -11.2 out-out-out SNCooo out-out ActLoopNT-out 7.0472 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -108.72, 11.71 APE9-dihe-in -76.28, 141.09 APE8-dihe-in -79.7, 72.15 APE8-rot-na 35.54 APE67-dihe-in -64.78, -14.16 -60.89, -45.58 APE12-dist-na 16.8433 APE11-dist-na 18.4238 APE10-dist-na 13.4267 APE9-dist-out 8.5327 None None None XRAY 2.14 0.226 0.258 B 271.0 266.0 0 29 29 0 [[402, 653]] 1.0 7l5p Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7R60A Q06187 389 659 659.0 2IE:701 Type1.5_Back Inactive DFGin 6.5148 13.922 BLBplus -135.67, 177.92 55.11, 25.57 -60.25, 122.41 40.83, 93.29 81.76, -7.18 out-out out 15.2299 Saltbr-out 17.2398 HRD-in -74.28, -48.51 76.99, -14.13 out-out-out SNCooo out-out ActLoopNT-out 8.4373 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -124.24, 13.12 APE9-dihe-in -74.74, 147.74 APE8-dihe-in -82.8, 65.47 APE8-rot-na 27.45 APE67-dihe-in -72.09, -9.98 -50.36, -44.52 APE12-dist-na 17.2612 APE11-dist-na 19.3353 APE10-dist-na 14.3601 APE9-dist-out 9.0243 None None None XRAY 1.94 0.218 0.265 A 271.0 271.0 0 29 29 0 [[402, 653]] 1.0 7r60 Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 8E2MA Q06187 389 658 659.0 UB6:701 Type1.5_Back Inactive DFGin 6.4168 13.2774 BLBplus -135.95, 175.73 60.58, 22.64 -69.16, 126.37 33.8, 94.14 80.52, -5.26 out-out out 14.842 Saltbr-out 14.6938 HRD-in -72.17, -50.81 78.81, -7.29 out-out-out SNCooo out-out ActLoopNT-out 8.3035 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -121.77, 12.85 APE9-dihe-in -73.25, 147.46 APE8-dihe-in -80.05, 65.27 APE8-rot-na 31.24 APE67-dihe-in -71.17, -9.43 -53.33, -45.23 APE12-dist-na 16.919 APE11-dist-na 19.0484 APE10-dist-na 14.2362 APE9-dist-out 9.0535 None None None XRAY 1.904 0.158 0.199 A 271.0 270.0 0 29 29 0 [[402, 653]] 1.0 8e2m Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6W7OA Q06187 396 656 659.0 TL7:60701 Type1.5_Back Inactive DFGin 5.9641 13.0637 BLBplus -130.77, 168.26 53.04, 30.28 -64.21, 121.6 37.17, 91.44 71.98, 4.56 out-out out 14.4625 Saltbr-out 15.2427 HRD-in -75.45, -50.93 78.96, -16.73 out-out-out SNCooo out-out ActLoopNT-out 8.1876 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -125.26, 14.94 APE9-dihe-in -73.36, 139.85 APE8-dihe-in -76.55, 60.58 APE8-rot-na 30.86 APE67-dihe-in -64.34, -12.26 -50.1, -48.74 APE12-dist-na 17.1583 APE11-dist-na 18.3158 APE10-dist-na 13.6743 APE9-dist-out 8.8077 None None None XRAY 2.17 0.198 0.24 A 277.0 261.0 0 29 29 0 [[402, 653]] 1.0 6w7o Homo sapiens TYR_BTK_HUMAN TYR 6.6e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6W7OB Q06187 396 658 659.0 TL7:60701 Type1.5_Back Inactive DFGin 5.6958 13.0469 BLBplus -127.43, 170.84 53.49, 29.22 -63.0, 121.63 37.69, 90.95 76.44, -4.99 out-out out 14.4002 Saltbr-out 16.3289 HRD-in -75.03, -53.49 79.63, -12.46 out-out-out SNCooo out-out ActLoopNT-out 8.3144 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -125.25, 8.08 APE9-dihe-in -68.1, 141.15 APE8-dihe-in -74.31, 63.69 APE8-rot-na 30.16 APE67-dihe-in -66.96, -10.21 -55.5, -47.35 APE12-dist-na 17.2797 APE11-dist-na 18.9134 APE10-dist-na 14.0197 APE9-dist-out 8.9144 None None None XRAY 2.17 0.198 0.24 B 277.0 263.0 0 29 29 0 [[402, 653]] 1.0 6w7o Homo sapiens TYR_BTK_HUMAN TYR 6.6e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6W8IC Q06187 395 657 659.0 TKY:701 Type1.5_Back Inactive DFGin 5.5583 12.8227 BLBplus -117.63, 170.82 49.97, 29.21 -63.96, 116.55 45.17, 88.86 76.02, -3.1 out-out out 14.7388 Saltbr-out 13.2847 HRD-in -79.58, -47.11 69.95, -10.05 out-out-out SNCooo out-out ActLoopNT-out 6.8084 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -64.77, -21.56 APE9-dihe-in -54.94, 130.08 APE8-dihe-in -81.13, 72.07 APE8-rot-na 26.49 APE67-dihe-in -61.37, -40.54 -59.95, -39.87 APE12-dist-na 17.6379 APE11-dist-na 18.4392 APE10-dist-na 13.269 APE9-dist-out 8.4146 None None None XRAY 3.8 0.213 0.251 C 277.0 263.0 0 29 29 0 [[402, 653]] 1.0 6w8i Homo sapiens TYR_BTK_HUMAN TYR 6.6e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 8DSOB Q06187 392 659 659.0 TOO:701 Type1.5_Back Inactive DFGin 6.4706 13.1468 BLBplus -138.1, 175.93 59.42, 42.3 -94.78, 139.63 38.49, 72.34 77.13, -32.52 out-none out 16.7743 Saltbr-none 999.0 HRD-in -76.82, -50.13 77.08, -34.25 none-out-out SNCnoo out-out ActLoopNT-out 7.1188 ActLoopCT-out TYR APEdihe_iooai APEdist_aaao APE10-dihe-in -98.57, 164.86 APE9-dihe-out -61.48, -30.65 APE8-dihe-out -63.04, 0.9 APE8-rot-na 339.5 APE67-dihe-in -68.19, -19.53 -60.43, -34.94 APE12-dist-na 21.6921 APE11-dist-na 21.8738 APE10-dist-na 16.2509 APE9-dist-out 11.9043 None None None XRAY 2.334 0.245 0.292 B 277.0 258.0 10 29 21 8 [[402, 653]] 1.0 8dso Homo sapiens TYR_BTK_HUMAN TYR 6.6e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 4YHFA Q06187 391 658 659.0 4C9:701 Type1.5_Back Inactive DFGin 6.3243 13.0827 BLBplus -141.4, 166.78 57.13, 26.67 -70.23, 122.45 37.58, 91.72 87.97, -7.25 out-none out 17.516 Saltbr-none 999.0 HRD-in -79.27, -46.14 75.71, -14.06 none-out-out SNCnoo out-out ActLoopNT-out 7.3496 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.55, 11.84 APE9-dihe-in -70.19, 142.86 APE8-dihe-in -78.67, 65.67 APE8-rot-na 30.17 APE67-dihe-in -65.6, -17.22 -53.11, -46.1 APE12-dist-na 16.8548 APE11-dist-na 18.4206 APE10-dist-na 14.5628 APE9-dist-out 8.6149 None None None XRAY 2.2 0.176 0.208 A 278.0 268.0 0 29 29 0 [[402, 653]] 1.0 4yhf Homo sapiens TYR_BTK_HUMAN TYR 6.6e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 4YHFB Q06187 390 658 659.0 4C9:703 Type1.5_Back Inactive DFGin 5.4242 12.8527 BLBplus -143.9, 171.03 56.17, 27.88 -72.24, 122.6 39.36, 89.32 83.47, -7.37 out-out out 13.9304 Saltbr-out 11.7697 HRD-in -75.2, -52.89 82.94, -9.58 out-out-out SNCooo out-out ActLoopNT-out 7.105 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -91.15, 0.37 APE9-dihe-in -73.16, 140.31 APE8-dihe-in -80.39, 71.14 APE8-rot-na 31.93 APE67-dihe-in -66.78, -11.99 -60.75, -42.81 APE12-dist-na 17.038 APE11-dist-na 18.4091 APE10-dist-na 13.2525 APE9-dist-out 8.4867 None None None XRAY 2.2 0.176 0.208 B 278.0 269.0 0 29 29 0 [[402, 653]] 1.0 4yhf Homo sapiens TYR_BTK_HUMAN TYR 6.6e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5P9IA Q06187 389 659 659.0 1E8:701 Type1.5_Back Inactive DFGin 5.8156 13.143 BLBplus -132.96, 170.25 54.94, 29.06 -65.92, 126.76 36.65, 92.12 73.44, -5.74 out-out out 14.7016 Saltbr-out 15.1827 HRD-in -73.21, -51.74 79.25, -8.77 out-out-out SNCooo out-out ActLoopNT-out 8.1669 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -117.83, 16.54 APE9-dihe-in -74.83, 144.69 APE8-dihe-in -79.03, 64.34 APE8-rot-na 27.14 APE67-dihe-in -70.64, -9.5 -53.48, -42.88 APE12-dist-na 16.9415 APE11-dist-na 18.9306 APE10-dist-na 14.1355 APE9-dist-out 8.8148 None None None XRAY 1.11 0.196 0.211 A 279.0 271.0 0 29 29 0 [[402, 653]] 1.0 5p9i Homo sapiens TYR_BTK_HUMAN TYR 6.7e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5P9JA Q06187 394 659 659.0 8E8:701 Type1.5_Back Inactive DFGin 5.9153 13.2884 BLBplus -133.53, 169.05 56.75, 29.39 -67.86, 126.34 32.9, 92.13 74.05, -4.59 out-out out 14.625 Saltbr-out 14.8958 HRD-in -67.96, -50.37 78.37, -13.99 out-out-out SNCooo out-out ActLoopNT-out 8.1935 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -118.06, 10.3 APE9-dihe-in -68.49, 148.63 APE8-dihe-in -85.54, 61.1 APE8-rot-na 26.47 APE67-dihe-in -74.48, -9.93 -47.45, -41.8 APE12-dist-na 16.5244 APE11-dist-na 18.7267 APE10-dist-na 14.0963 APE9-dist-out 8.9073 None None None XRAY 1.08 0.21 0.224 A 279.0 263.0 3 29 26 3 [[402, 653]] 1.0 5p9j Homo sapiens TYR_BTK_HUMAN TYR 6.7e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5P9MA Q06187 389 659 659.0 7GB:701 Type1.5_Back Inactive DFGin 5.8516 13.3293 BLBplus -132.36, 168.19 59.41, 28.36 -65.38, 123.69 35.52, 89.9 75.34, -4.93 out-out out 14.7801 Saltbr-out 15.0393 HRD-in -68.48, -50.59 79.48, -16.76 out-out-out SNCooo out-out ActLoopNT-out 8.1708 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -51.99, -28.41 APE9-dihe-in -155.94, 144.77 APE8-dihe-in -76.22, 66.03 APE8-rot-na 26.43 APE67-dihe-in -70.51, -11.44 -52.67, -42.73 APE12-dist-na 16.2836 APE11-dist-na 16.7244 APE10-dist-na 16.1093 APE9-dist-out 8.8831 None None None XRAY 1.41 0.18 0.201 A 279.0 271.0 0 29 29 0 [[402, 653]] 1.0 5p9m Homo sapiens TYR_BTK_HUMAN TYR 6.7e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 3GENA Q06187 392 658 659.0 B43:1 Type1.5_Back Inactive DFGin 5.9158 13.0055 BLBplus -134.69, 169.57 56.28, 25.37 -64.74, 122.88 36.07, 90.43 78.22, -5.97 out-out out 14.6829 Saltbr-out 14.598 HRD-in -73.9, -49.88 78.36, -14.16 out-out-out SNCooo out-out ActLoopNT-out 8.1654 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -118.65, 5.65 APE9-dihe-in -71.16, 141.23 APE8-dihe-in -74.25, 62.53 APE8-rot-na 28.89 APE67-dihe-in -70.5, -10.0 -52.03, -42.55 APE12-dist-na 16.9751 APE11-dist-na 18.9384 APE10-dist-na 13.9381 APE9-dist-out 8.8324 None None None XRAY 1.6 0.195 0.232 A 283.0 264.0 3 29 29 0 [[402, 653]] 1.0 3gen Homo sapiens TYR_BTK_HUMAN TYR 7.1e-93 316.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6E4FA Q06187 389 658 659.0 HRA:701 Type1.5_Back Inactive DFGin 6.1396 13.5953 BLBplus -125.51, 171.21 65.06, 21.65 -65.55, 123.81 39.55, 91.62 75.8, -3.81 out-out out 14.8801 Saltbr-out 17.078 HRD-in -70.37, -51.25 79.25, -11.85 out-out-out SNCooo out-out ActLoopNT-out 8.1679 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.58, 7.18 APE9-dihe-in -70.93, 142.86 APE8-dihe-in -80.71, 63.54 APE8-rot-na 29.0 APE67-dihe-in -70.94, -8.1 -51.86, -45.52 APE12-dist-na 16.8591 APE11-dist-na 18.4793 APE10-dist-na 13.6257 APE9-dist-out 8.7071 None None None XRAY 1.15 0.131 0.15 A 290.0 270.0 0 29 29 0 [[402, 653]] 1.0 6e4f Homo sapiens TYR_BTK_HUMAN TYR 7.8e-93 316.5 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5FBOA Q06187 392 659 659.0 5WH:1001,5WE:1002 Type1.5_Back,Allosteric Inactive DFGin 4.9335 14.0794 BLBplus -127.34, -179.25 51.08, 30.68 -63.41, 107.22 34.59, 90.39 57.28, 50.21 out-out out 11.9542 Saltbr-out 14.2301 HRD-in -61.25, -46.68 71.35, -12.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.03, 2.31 APE9-dihe-in -65.0, 140.35 APE8-dihe-in -74.92, 62.27 APE8-rot-na 32.17 APE67-dihe-in -71.92, -9.91 -51.18, -45.3 APE12-dist-na 999.0 APE11-dist-na 17.4062 APE10-dist-na 13.1956 APE9-dist-out 8.1123 None None None XRAY 1.894 0.212 0.236 A 271.0 255.0 13 29 16 13 [[402, 653]] 1.0 5fbo Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 8FLNA Q06187 395 657 659.0 Y7W:701,BTB:705 Type1.5_Front,Allosteric Inactive DFGin 5.5559 14.0954 BLBplus -121.98, 170.19 56.55, 34.27 -69.53, 121.06 33.29, 92.29 82.95, 0.33 out-out out 16.422 Saltbr-out 17.9428 HRD-in -75.91, -54.85 81.87, -11.12 out-out-out SNCooo out-out ActLoopNT-out 7.5944 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -104.55, 8.91 APE9-dihe-in -70.03, 146.41 APE8-dihe-in -76.42, 62.91 APE8-rot-na 20.16 APE67-dihe-in -67.77, -10.54 -54.41, -41.28 APE12-dist-na 16.7992 APE11-dist-na 19.0582 APE10-dist-na 14.3578 APE9-dist-out 8.5866 None None None XRAY 1.334 0.193 0.199 A 273.0 263.0 0 29 29 0 [[402, 653]] 1.0 8fln Homo sapiens TYR_BTK_HUMAN TYR 4.6e-93 317.2 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5FBNC Q06187 395 658 659.0 5WF:701,5WE:702 Type1.5_Front,Allosteric Inactive DFGin 6.2343 13.4854 BLBplus -138.97, 172.93 64.41, 21.2 -64.91, 134.85 43.34, 89.93 78.28, -17.1 out-out out 15.0072 Saltbr-out 15.714 HRD-in -67.81, -54.89 86.66, -24.42 out-out-out SNCooo out-out ActLoopNT-out 8.1944 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out 143.31, -31.01 APE9-dihe-in -63.12, 135.49 APE8-dihe-in -76.38, 65.1 APE8-rot-na 32.35 APE67-dihe-in -72.98, -10.12 -50.46, -47.16 APE12-dist-na 999.0 APE11-dist-na 17.8308 APE10-dist-na 12.6083 APE9-dist-out 8.1809 None None None XRAY 1.8 0.182 0.226 C 271.0 256.0 8 29 21 8 [[402, 653]] 1.0 5fbn Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6X3OA Q06187 395 659 659.0 ULY:701,5WE:702 Type1.5_Front,Allosteric Inactive DFGin 6.2723 14.2227 BLBplus -137.77, 172.12 61.73, 21.35 -60.85, 127.83 37.95, 92.24 73.87, -6.38 out-out out 15.17 Saltbr-out 16.0811 HRD-in -75.67, -53.5 81.79, -14.06 out-out-out SNCooo out-out ActLoopNT-out 8.4586 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -109.73, 7.42 APE9-dihe-in -70.0, 142.33 APE8-dihe-in -75.39, 64.77 APE8-rot-na 34.47 APE67-dihe-in -69.38, -11.52 -56.58, -43.22 APE12-dist-na 16.806 APE11-dist-na 18.6039 APE10-dist-na 13.6409 APE9-dist-out 8.5906 None None None XRAY 1.9 0.181 0.213 A 271.0 265.0 0 29 29 0 [[402, 653]] 1.0 6x3o Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6X3OB Q06187 393 659 659.0 ULY:701,5WE:702 Type1.5_Front,Allosteric Inactive DFGin 6.2875 14.0893 BLBplus -138.35, 171.76 61.86, 21.21 -60.49, 128.12 38.08, 92.33 72.6, -5.67 out-out out 15.3768 Saltbr-out 16.6794 HRD-in -75.8, -53.34 80.45, -11.96 out-out-out SNCooo out-out ActLoopNT-out 8.3968 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -114.41, 10.63 APE9-dihe-in -69.48, 144.31 APE8-dihe-in -76.78, 65.24 APE8-rot-na 34.23 APE67-dihe-in -70.15, -10.73 -56.21, -43.96 APE12-dist-na 16.68 APE11-dist-na 18.4631 APE10-dist-na 13.5744 APE9-dist-out 8.483 None None None XRAY 1.9 0.181 0.213 B 271.0 267.0 0 29 29 0 [[402, 653]] 1.0 6x3o Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 8FLLA Q06187 395 658 659.0 Y7W:701,BTB:705 Type1.5_Front,Allosteric Inactive DFGin 5.5931 14.0905 BLBplus -122.49, 170.09 55.08, 30.22 -63.61, 119.39 33.22, 95.24 81.67, 3.52 out-none out 16.3522 Saltbr-none 999.0 HRD-in -74.39, -53.68 82.2, -12.98 none-out-out SNCnoo out-out ActLoopNT-out 7.5618 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.74, 7.32 APE9-dihe-in -70.19, 146.45 APE8-dihe-in -76.31, 63.24 APE8-rot-na 25.19 APE67-dihe-in -68.43, -11.11 -54.01, -42.0 APE12-dist-na 16.7425 APE11-dist-na 18.9367 APE10-dist-na 14.2647 APE9-dist-out 8.5135 None None None XRAY 1.498 0.186 0.202 A 273.0 264.0 0 29 29 0 [[402, 653]] 1.0 8fll Homo sapiens TYR_BTK_HUMAN TYR 6.2e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5FBND Q06187 394 658 659.0 5WF:702,5WE:703,5WE:704,5WE:705 Type1.5_Front,Allosteric,Allosteric,Allosteric Inactive DFGin 6.2504 13.4724 BLBplus -137.76, 172.64 65.66, 19.16 -62.24, 135.48 45.56, 88.91 74.32, -16.76 out-out out 15.0558 Saltbr-out 15.7515 HRD-in -65.32, -54.88 86.04, -26.38 out-out-none SNCoon out-none ActLoopNT-out 8.1947 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.18 APE8-dihe-in -78.24, 64.6 APE8-rot-na 31.95 APE67-dihe-in -74.36, -8.3 -50.81, -46.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8979 None None None XRAY 1.8 0.182 0.226 D 271.0 255.0 10 29 19 10 [[402, 653]] 1.0 5fbn Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6X3PA Q06187 394 659 659.0 UM4:701,UM4:702,BTB:704 Type1.5_Front,Allosteric,Type1 Inactive DFGin 6.3555 13.7902 BLBplus -142.49, 179.49 63.69, 18.67 -57.75, 127.0 32.08, 89.29 76.23, -5.08 out-out out 15.1688 Saltbr-out 16.3473 HRD-in -78.69, -54.16 80.75, -12.21 out-out-out SNCooo out-out ActLoopNT-out 8.6625 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -108.53, 5.56 APE9-dihe-in -69.62, 142.82 APE8-dihe-in -80.89, 62.04 APE8-rot-na 33.01 APE67-dihe-in -69.33, -8.25 -49.92, -44.89 APE12-dist-na 16.7678 APE11-dist-na 18.5649 APE10-dist-na 13.5987 APE9-dist-out 8.7681 None None None XRAY 1.34 0.205 0.217 A 271.0 266.0 0 29 29 0 [[402, 653]] 1.0 6x3p Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 3PIYA Q06187 391 658 659.0 585:1 Type1 Inactive DFGin 6.5898 14.8046 None -86.48, 116.32 -39.12, -55.85 -103.57, 159.77 292.78, 91.05 -55.45, 135.27 out-out out 10.5998 Saltbr-out 6.1662 HRD-in -82.22, -47.83 77.57, -19.27 out-out-out SNCooo out-out ActLoopNT-out 14.1198 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.57, 20.38 APE9-dihe-in -77.53, 136.74 APE8-dihe-in -77.13, 67.95 APE8-rot-na 32.82 APE67-dihe-in -63.75, -20.32 -55.08, -51.26 APE12-dist-na 17.7544 APE11-dist-na 17.7304 APE10-dist-na 12.4391 APE9-dist-out 8.1766 None None None XRAY 2.55 0.228 0.295 A 274.0 262.0 6 29 29 0 [[402, 653]] 1.0 3piy Homo sapiens TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 3PJ2A Q06187 391 659 659.0 04K:1 Type1.5_Back Inactive DFGin 4.8792 13.7655 None -125.57, -174.91 51.36, 35.37 -74.45, 999.0 30.81, 92.87 999.0, 999.0 out-out out 10.8742 Saltbr-out 6.4644 HRD-in -71.49, -54.79 77.51, -7.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.76 APE8-dihe-in -75.06, 65.46 APE8-rot-na 29.28 APE67-dihe-in -67.05, -14.12 -51.89, -45.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1661 None None None XRAY 1.75 0.231 0.263 A 274.0 248.0 21 29 11 18 [[402, 653]] 1.0 3pj2 Homo sapiens TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5XYZA Q06187 394 656 659.0 GYL:701 Type1 Inactive DFGinter 9.3469 8.304 BABtrans -99.77, 139.1 -95.47, 13.14 -102.26, 131.3 176.17, 60.97 88.39, 12.77 out-out out 11.5781 Saltbr-out 9.2547 HRD-in -78.14, -61.12 90.65, -27.42 out-out-none SNCoon out-none ActLoopNT-out 5.2282 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 77.34 APE8-dihe-in -83.17, 111.34 APE8-rot-na 20.92 APE67-dihe-in -73.15, -5.2 -57.61, -54.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.4949 None None None XRAY 2.64 0.268 0.326 A 265.0 230.0 33 29 15 14 [[402, 653]] 1.0 5xyz Homo sapiens TYR_BTK_HUMAN TYR 5.5e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 5XYZB Q06187 394 656 659.0 GYL:701 Type1 Inactive DFGinter 9.4328 8.0755 BABtrans -80.9, 137.65 -92.66, -0.21 -77.59, 136.6 176.7, 69.08 72.83, 36.08 out-out out 11.3866 Saltbr-out 9.6743 HRD-in -68.79, -59.6 106.37, -54.65 out-out-none SNCoon out-none ActLoopNT-out 5.327 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 75.53 APE8-dihe-in -66.49, 110.19 APE8-rot-na 22.3 APE67-dihe-in -70.95, -22.66 -57.21, -50.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6562 None None None XRAY 2.64 0.268 0.326 B 265.0 234.0 29 29 15 14 [[402, 653]] 1.0 5xyz Homo sapiens TYR_BTK_HUMAN TYR 5.5e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 7YC9A Q06187 395 658 659.0 IS4:701 Type1 Inactive DFGinter 8.002 8.7887 BABtrans -86.32, 131.84 -104.1, 6.91 -65.2, 125.85 176.47, 71.74 60.46, 29.78 out-out out 11.7136 Saltbr-out 13.1685 HRD-in -89.69, -58.41 77.25, -3.96 out-out-in SNCooi out-in ActLoopNT-out 8.7115 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.07, 157.14 APE9-dihe-in -156.9, 156.06 APE8-dihe-in -80.91, 97.28 APE8-rot-na 28.13 APE67-dihe-in -74.5, -5.29 -49.69, -51.23 APE12-dist-na 18.2489 APE11-dist-na 16.1716 APE10-dist-na 13.5257 APE9-dist-in 6.316 None None None XRAY 1.4 0.167 0.187 A 269.0 264.0 0 29 29 0 [[402, 653]] 1.0 7yc9 Homo sapiens TYR_BTK_HUMAN TYR 5.9e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 3OCTA Q06187 394 656 659.0 1N1:663 Type1 Inactive DFGinter 9.5513 8.0475 BABtrans -83.49, 139.01 -103.95, 15.92 -87.02, 132.92 181.28, 97.3 77.87, 26.97 in-out in 9.203 Saltbr-out 7.7453 HRD-in -70.28, -48.13 67.57, -13.36 out-out-none SNCoon out-none ActLoopNT-out 5.3805 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 95.42 APE8-dihe-in -60.66, 106.57 APE8-rot-na 28.18 APE67-dihe-in -77.0, -13.84 -55.35, -41.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.7096 V555R None None XRAY 1.95 0.199 0.251 A 265.0 244.0 19 29 15 14 [[402, 653]] 1.0 3oct Homo sapiens TYR_BTK_HUMAN TYR 2.3e-93 318.2 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 6NFIA Q06187 392 659 659.0 KLP:701 Type1 Inactive DFGinter 9.1428 7.9961 None -88.38, 102.06 -66.25, -30.62 -22.04, 98.6 180.01, 49.84 74.77, 999.0 out-out out 10.7923 Saltbr-out 7.7832 HRD-in -72.39, -52.0 75.98, -4.69 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 84.4 APE9-dihe-in -72.68, 133.55 APE8-dihe-in -78.11, 68.48 APE8-rot-na 34.66 APE67-dihe-in -67.64, -17.9 -60.47, -41.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.4316 None None None XRAY 2.41 0.22 0.248 A 268.0 243.0 25 29 13 16 [[402, 653]] 1.0 6nfi Homo sapiens TYR_BTK_HUMAN TYR 5.8e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_HUMAN 3PJ3A Q06187 391 659 659.0 04L:1 Type1 Inactive None 999.0 999.0 None -130.95, -155.74 -154.88, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.4381 Saltbr-in 3.5253 HRD-in -72.1, -53.46 75.95, -3.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.29 APE8-dihe-in -70.28, 66.1 APE8-rot-na 28.08 APE67-dihe-in -69.44, -11.85 -54.05, -43.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3186 None None None XRAY 1.85 0.234 0.254 A 274.0 240.0 29 29 10 19 [[402, 653]] 1.0 3pj3 Homo sapiens TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 6MNYB P35991 395 656 659.0 No_ligand No_ligand Inactive DFGin 5.2333 13.7059 BLBplus -125.1, 165.75 52.84, 32.49 -58.38, 102.48 38.24, 93.39 84.1, 10.45 out-out out 15.3597 Saltbr-out 15.3618 HRD-in -76.61, -44.47 72.94, -21.5 out-out-none SNCoon out-none ActLoopNT-out 8.164 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.11 APE8-dihe-in -84.12, 99.31 APE8-rot-na 27.5 APE67-dihe-in -54.63, -7.98 -44.55, -71.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6525 None None None XRAY 2.8 0.199 0.257 B 276.0 253.0 9 29 20 9 [[402, 653]] 1.0 6mny Mus musculus TYR_BTK_MOUSE TYR 2.2e-92 315.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 4XI2A P35991 214 657 659.0 No_ligand No_ligand Inactive DFGin 6.073 13.6172 BLBplus -129.77, 176.3 55.32, 29.33 -68.82, 130.66 33.95, 96.53 79.95, -18.34 out-out out 16.133 Saltbr-out 15.266 HRD-in -76.78, -41.3 82.23, -28.62 out-out-out SNCooo out-out ActLoopNT-out 7.8601 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -123.97, 14.53 APE9-dihe-in -69.24, 140.86 APE8-dihe-in -65.55, 63.89 APE8-rot-na 337.2 APE67-dihe-in -72.94, -14.83 -61.29, -38.22 APE12-dist-na 16.7722 APE11-dist-na 18.9503 APE10-dist-na 14.481 APE9-dist-out 8.7636 None None None XRAY 2.6 0.231 0.248 A 446.0 421.0 0 29 29 0 [[402, 653]] 1.0 4xi2 Mus musculus TYR_BTK_MOUSE TYR 8.6e-92 313.2 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 8S93A P35991 1 659 659.0 9AJ:60701 Type1 Inactive DFGin 5.613 14.0422 BLBplus -138.68, 161.71 56.66, 47.49 -90.96, 127.53 49.22, 88.62 76.51, 0.36 out-none out 14.4956 Saltbr-none 999.0 HRD-in -85.34, -48.23 72.28, -3.13 none-out-out SNCnoo out-out ActLoopNT-out 8.0076 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -98.7, -4.82 APE9-dihe-in -69.1, 134.65 APE8-dihe-in -78.27, 78.56 APE8-rot-na 30.94 APE67-dihe-in -72.61, -7.52 -67.45, -38.51 APE12-dist-na 17.6112 APE11-dist-na 19.3217 APE10-dist-na 14.1247 APE9-dist-out 9.1621 Q91A,I92A,I94A,I95A,K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 2.1 0.201 0.246 A 457.0 422.0 0 29 29 0 [[402, 653]] 1.0 8s93 Mus musculus TYR_BTK_MOUSE TYR 5.9e-92 313.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 8GMBA P35991 214 659 659.0 9AJ:701 Type1 Inactive DFGin 5.509 12.6987 BLBplus -147.75, 172.59 51.29, 39.7 -66.24, 115.12 38.31, 84.34 67.51, 23.9 out-none out 16.0609 Saltbr-none 999.0 HRD-in -54.37, -39.85 77.19, -42.53 none-out-out SNCnoo out-out ActLoopNT-out 7.9557 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -78.99, 5.07 APE9-dihe-in -74.2, 132.98 APE8-dihe-in -77.72, 77.83 APE8-rot-na 351.22 APE67-dihe-in -56.74, -42.39 -65.52, -27.41 APE12-dist-na 17.4083 APE11-dist-na 19.2639 APE10-dist-na 14.5006 APE9-dist-out 9.5597 E298A,K300A,E301A,A384P,S386P,T387P,A388P,L390F,K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 3.4 0.273 0.289 A 659.0 438.0 0 29 29 0 [[402, 653]] 1.0 8gmb Mus musculus TYR_BTK_MOUSE TYR 1.4e-91 312.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 6MNYA P35991 395 656 659.0 JVP:701 Type1.5_Back Inactive DFGin 5.4078 13.4543 BLBplus -126.31, 164.74 54.03, 31.46 -57.89, 101.97 38.23, 93.33 85.13, 10.46 out-out out 15.0693 Saltbr-out 15.1381 HRD-in -77.46, -44.57 71.97, -19.22 out-out-out SNCooo out-out ActLoopNT-out 8.1773 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 2.74 APE9-dihe-in -82.84, 149.02 APE8-dihe-in -75.51, 71.13 APE8-rot-na 33.23 APE67-dihe-in -67.32, -6.29 -62.61, -44.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.5745 APE9-dist-out 9.2303 None None None XRAY 2.8 0.199 0.257 A 276.0 252.0 10 29 19 10 [[402, 653]] 1.0 6mny Mus musculus TYR_BTK_MOUSE TYR 2.2e-92 315.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 8FD9A P35991 396 659 659.0 XQQ:60801 Type1.5_Back Inactive DFGin 5.4245 13.8419 BLBplus -143.85, 171.16 60.8, 23.05 -58.7, 125.33 37.88, 85.05 75.51, 8.83 out-none out 15.044 Saltbr-none 999.0 HRD-in -74.88, -52.43 83.83, -11.3 none-out-out SNCnoo out-out ActLoopNT-out 7.722 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -104.17, 5.86 APE9-dihe-in -69.45, 141.3 APE8-dihe-in -71.5, 68.31 APE8-rot-na 27.11 APE67-dihe-in -75.09, -1.83 -59.51, -38.97 APE12-dist-na 16.7855 APE11-dist-na 19.0074 APE10-dist-na 14.1927 APE9-dist-out 8.6553 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 1.7 0.189 0.228 A 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 8fd9 Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 8FF0A P35991 396 659 659.0 7GB:60801 Type1.5_Back Inactive DFGin 5.2191 13.6773 BLBplus -132.25, 167.19 58.69, 27.63 -65.72, 123.75 35.91, 87.62 75.14, 19.75 out-none out 14.9533 Saltbr-none 999.0 HRD-in -69.37, -50.08 80.05, -16.38 none-out-out SNCnoo out-out ActLoopNT-out 7.7789 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.85, -26.74 APE9-dihe-in -55.22, 143.13 APE8-dihe-in -77.98, 65.87 APE8-rot-na 26.46 APE67-dihe-in -65.77, -20.77 -52.66, -49.09 APE12-dist-na 17.1354 APE11-dist-na 19.1037 APE10-dist-na 13.5458 APE9-dist-out 8.8625 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 2.6 0.242 0.267 A 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 8ff0 Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9EJXA P35991 396 659 659.0 A1BI1:60701 Type1.5_Back Inactive DFGin 5.364 13.4534 BLBplus -153.42, 172.61 57.75, 36.77 -82.82, 135.54 38.01, 92.52 69.8, 4.91 out-none out 14.6653 Saltbr-none 999.0 HRD-in -84.35, -55.61 84.23, -7.11 none-out-out SNCnoo out-out ActLoopNT-out 7.5531 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.32, 5.81 APE9-dihe-in -72.43, 137.34 APE8-dihe-in -77.97, 68.28 APE8-rot-na 30.72 APE67-dihe-in -70.58, -7.72 -58.08, -35.85 APE12-dist-na 16.4456 APE11-dist-na 18.506 APE10-dist-na 13.7176 APE9-dist-out 8.5004 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 2.86 0.264 0.296 A 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 9ejx Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9ME2A P35991 396 659 659.0 A1BKW:60701 Type1.5_Back Inactive DFGin 6.1761 13.862 BLBplus -153.57, 173.0 58.45, 37.1 -82.56, 135.76 37.63, 82.21 70.07, 5.04 out-none out 15.5031 Saltbr-none 999.0 HRD-in -83.6, -55.11 84.56, -6.48 none-out-out SNCnoo out-out ActLoopNT-out 7.8259 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -110.64, 5.72 APE9-dihe-in -72.11, 137.95 APE8-dihe-in -77.41, 68.47 APE8-rot-na 30.58 APE67-dihe-in -71.12, -7.96 -57.83, -36.21 APE12-dist-na 16.6386 APE11-dist-na 18.7398 APE10-dist-na 13.835 APE9-dist-out 8.7605 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 3.38 0.236 0.286 A 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 9me2 Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9ME3A P35991 396 659 659.0 A1BJE:60701 Type1.5_Back Inactive DFGin 5.2024 14.0765 BLBplus -154.07, 173.19 58.4, 37.61 -82.21, 135.41 37.94, 82.49 69.54, 4.73 out-none out 15.4183 Saltbr-none 999.0 HRD-in -84.92, -55.91 84.63, -7.62 none-out-out SNCnoo out-out ActLoopNT-out 7.6863 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.21, 5.41 APE9-dihe-in -72.58, 137.61 APE8-dihe-in -77.4, 68.82 APE8-rot-na 30.55 APE67-dihe-in -71.2, -8.1 -58.02, -36.38 APE12-dist-na 16.6269 APE11-dist-na 18.7046 APE10-dist-na 13.8611 APE9-dist-out 8.5836 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 3.05 0.228 0.288 A 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 9me3 Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9EJJA P35991 394 659 659.0 A1BIZ:701 Type1.5_Front Inactive DFGin 5.7614 13.6487 BLBplus -147.32, 173.09 58.85, 28.19 -76.07, 130.26 40.28, 86.74 72.63, 22.79 out-out out 15.3914 Saltbr-out 16.7212 HRD-in -81.76, -55.09 79.59, -6.11 out-out-out SNCooo out-out ActLoopNT-out 7.8703 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -88.9, -177.8 APE9-dihe-out -69.14, -44.42 APE8-dihe-out -58.97, -6.69 APE8-rot-na 334.43 APE67-dihe-in -64.23, -15.53 -59.83, -30.31 APE12-dist-na 999.0 APE11-dist-na 19.696 APE10-dist-na 15.0024 APE9-dist-out 11.0263 L390G,Y551E,Y617P None None XRAY 2.03 0.225 0.242 A 279.0 258.0 8 29 22 7 [[402, 653]] 1.0 9ejj Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9EJJB P35991 394 659 659.0 A1BIZ:701 Type1.5_Front Inactive DFGin 5.5008 14.0729 BLBplus -153.48, 175.7 63.93, 27.52 -79.9, 134.25 41.75, 85.89 73.22, 13.03 out-out out 16.4746 Saltbr-out 15.5152 HRD-in -79.13, -52.93 77.61, -0.8 out-out-out SNCooo out-out ActLoopNT-out 7.9037 ActLoopCT-out TYR APEdihe_iooai APEdist_aaao APE10-dihe-in -93.15, 172.37 APE9-dihe-out -61.71, -38.19 APE8-dihe-out -62.73, -3.38 APE8-rot-na 336.57 APE67-dihe-in -68.39, -9.76 -59.68, -31.05 APE12-dist-na 999.0 APE11-dist-na 19.4777 APE10-dist-na 14.5039 APE9-dist-out 10.8675 L390G,Y551E,Y617P None None XRAY 2.03 0.225 0.242 B 279.0 256.0 10 29 21 8 [[402, 653]] 1.0 9ejj Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9EJRA P35991 394 659 659.0 A1BI0:701 Type1.5_Front Inactive DFGin 5.9148 13.6438 BLBplus -146.74, 166.14 62.28, 23.66 -68.17, 124.47 38.27, 88.12 78.54, 14.19 out-out out 15.6993 Saltbr-out 15.7409 HRD-in -72.31, -57.13 80.67, 0.3 out-out-out SNCooo out-out ActLoopNT-out 7.8158 ActLoopCT-out TYR APEdihe_iooai APEdist_aaao APE10-dihe-in -92.94, 175.88 APE9-dihe-out -65.52, -38.77 APE8-dihe-out -63.32, -1.31 APE8-rot-na 335.74 APE67-dihe-in -69.18, -9.94 -59.0, -31.83 APE12-dist-na 21.4888 APE11-dist-na 20.0612 APE10-dist-na 15.1372 APE9-dist-out 11.1199 L390G,Y551E,Y617P None None XRAY 2.1 0.25 0.295 A 279.0 260.0 6 29 23 6 [[402, 653]] 1.0 9ejr Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9EJRB P35991 394 659 659.0 A1BI0:701 Type1.5_Front Inactive DFGin 5.5791 14.023 BLBplus -146.82, 168.57 65.02, 26.83 -69.27, 132.22 36.8, 90.68 70.75, 10.33 out-out out 16.1259 Saltbr-out 17.3767 HRD-in -76.4, -57.97 82.93, -6.46 out-out-out SNCooo out-out ActLoopNT-out 7.8983 ActLoopCT-out TYR APEdihe_iooai APEdist_aaao APE10-dihe-in -73.95, 158.19 APE9-dihe-out -60.45, -36.51 APE8-dihe-out -63.06, -4.13 APE8-rot-na 335.95 APE67-dihe-in -67.11, -17.18 -54.59, -31.21 APE12-dist-na 999.0 APE11-dist-na 19.985 APE10-dist-na 13.9759 APE9-dist-out 10.8815 L390G,Y551E,Y617P None None XRAY 2.1 0.25 0.295 B 279.0 256.0 10 29 21 8 [[402, 653]] 1.0 9ejr Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9EJSA P35991 396 659 659.0 A1BI0:60701 Type1.5_Front Inactive DFGin 6.0971 14.0929 BLBplus -154.67, 173.53 58.61, 37.48 -82.66, 135.95 37.6, 82.44 70.22, 5.22 out-none out 15.4292 Saltbr-none 999.0 HRD-in -84.8, -55.83 84.5, -7.48 none-out-out SNCnoo out-out ActLoopNT-out 8.1013 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -110.34, 5.15 APE9-dihe-in -73.07, 137.61 APE8-dihe-in -77.55, 68.34 APE8-rot-na 30.59 APE67-dihe-in -71.3, -7.86 -58.39, -36.7 APE12-dist-na 16.6634 APE11-dist-na 18.5815 APE10-dist-na 13.5366 APE9-dist-out 8.4696 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 2.26 0.194 0.246 A 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 9ejs Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9EJSB P35991 396 659 659.0 A1BI0:60701 Type1.5_Front Inactive DFGin 5.6865 14.0361 BLBplus -156.42, 172.76 60.49, 20.29 -63.05, 132.72 45.29, 85.58 77.61, -1.77 out-none out 15.2245 Saltbr-none 999.0 HRD-in -73.66, -56.25 84.42, -8.07 none-out-out SNCnoo out-out ActLoopNT-out 7.6221 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -122.47, 7.16 APE9-dihe-in -70.4, 144.43 APE8-dihe-in -80.98, 77.13 APE8-rot-na 29.28 APE67-dihe-in -72.16, -5.06 -62.4, -44.39 APE12-dist-na 16.6362 APE11-dist-na 18.7295 APE10-dist-na 13.8692 APE9-dist-out 8.6443 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 2.26 0.194 0.246 B 271.0 262.0 2 29 29 0 [[402, 653]] 1.0 9ejs Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9EJSC P35991 396 659 659.0 A1BI0:60701 Type1.5_Front Inactive DFGin 5.7359 13.805 BLBplus -149.75, 171.22 61.78, 31.3 -76.97, 128.5 43.86, 90.23 72.89, 21.93 out-none out 14.9579 Saltbr-none 999.0 HRD-in -89.58, -48.29 82.25, -17.58 none-out-out SNCnoo out-out ActLoopNT-out 7.8728 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -125.95, 7.94 APE9-dihe-in -72.64, 139.26 APE8-dihe-in -74.43, 65.15 APE8-rot-na 26.63 APE67-dihe-in -70.23, -10.99 -55.69, -40.73 APE12-dist-na 16.965 APE11-dist-na 18.7295 APE10-dist-na 13.8121 APE9-dist-out 8.5488 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 2.26 0.194 0.246 C 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 9ejs Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 8S9FA P35991 392 659 659.0 1N1:801 Type1 Inactive DFGinter 9.7383 8.4773 BABtrans -103.75, 162.9 -98.62, -12.56 -74.46, 134.73 203.6, 82.29 75.53, 30.46 out-out out 11.3245 Saltbr-out 8.457 HRD-out -78.16, 120.76 -71.26, -27.71 out-out-none SNCoon out-none ActLoopNT-out 5.4638 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 89.3 APE8-rot-na 354.27 APE67-dihe-in -88.28, 1.83 -66.03, -37.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 L390G,Y551E,Y617P None None XRAY 2.6 0.244 0.284 A 279.0 254.0 14 29 15 14 [[402, 653]] 1.0 8s9f Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 8S9FB P35991 392 659 659.0 1N1:801 Type1 Inactive DFGinter 9.5087 8.4716 BABtrans -108.61, 149.63 -109.15, 7.92 -82.22, 131.91 185.43, 98.64 78.7, 27.48 out-out out 11.0192 Saltbr-out 10.3295 HRD-out -91.58, 112.75 -69.14, -29.29 out-out-out SNCooo out-out ActLoopNT-out 5.6813 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 166.92 APE9-dihe-in -91.32, 115.75 APE8-dihe-in -71.7, 107.6 APE8-rot-na 25.58 APE67-dihe-in -83.25, -12.58 -54.13, -30.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 16.1492 APE9-dist-out 18.604 L390G,Y551E,Y617P None None XRAY 2.6 0.244 0.284 B 279.0 255.0 13 29 17 12 [[402, 653]] 1.0 8s9f Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK

TYR_BTK (Tyrosine-protein kinase BTK)

Total number of chains: 24
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 22 91.7% 4Y95A
DFGinter BABtrans 2 8.3% 8S9FB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
BTK Q3ZC95_BOVIN 4Y95A Q3ZC95 395 659 659.0 746:60701 Type1 Inactive DFGin 6.6175 13.8598 BLBplus -121.38, 150.87 56.6, 35.77 -63.21, 129.98 38.15, 94.63 78.92, -1.55 out-out out 14.6244 Saltbr-out 16.1857 HRD-in -73.49, -58.3 84.27, -8.32 out-out-out SNCooo out-out ActLoopNT-out 7.9226 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -110.52, -5.28 APE9-dihe-in -66.23, 137.47 APE8-dihe-in -79.05, 62.77 APE8-rot-na 30.72 APE67-dihe-in -77.89, -2.13 -54.11, -40.82 APE12-dist-na 17.5052 APE11-dist-na 19.1412 APE10-dist-na 14.0853 APE9-dist-out 8.6558 L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P None None XRAY 1.599 0.155 0.184 A 266.0 265.0 0 29 29 0 [[402, 653]] 1.0 4y95 Bos taurus TYR_BTK_BOVIN TYR 1.4e-93 318.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase
BTK Q3ZC95_BOVIN 4Y95D Q3ZC95 395 659 659.0 746:60701 Type1 Inactive DFGin 6.6489 13.8623 BLBplus -120.58, 150.23 57.17, 35.26 -62.33, 130.63 38.01, 95.62 77.89, -2.4 out-out out 14.6289 Saltbr-out 16.219 HRD-in -73.6, -57.75 84.35, -9.39 out-out-out SNCooo out-out ActLoopNT-out 7.9005 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -110.57, -5.62 APE9-dihe-in -65.7, 137.52 APE8-dihe-in -78.52, 62.83 APE8-rot-na 30.81 APE67-dihe-in -77.8, -1.14 -54.26, -41.32 APE12-dist-na 17.5167 APE11-dist-na 19.15 APE10-dist-na 14.0784 APE9-dist-out 8.6269 L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P None None XRAY 1.599 0.155 0.184 D 266.0 265.0 0 29 29 0 [[402, 653]] 1.0 4y95 Bos taurus TYR_BTK_BOVIN TYR 1.4e-93 318.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase
BTK Q3ZC95_BOVIN 4Y93A Q3ZC95 1 658 659.0 746:60702 Type1 Inactive DFGin 6.8872 13.6546 BLBplus -120.16, 153.49 55.57, 32.74 -63.12, 134.52 38.43, 96.44 76.83, -2.76 out-out out 15.7792 Saltbr-out 13.6789 HRD-in -75.84, -56.25 76.77, -5.42 out-out-out SNCooo out-out ActLoopNT-out 7.8847 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.38, -2.7 APE9-dihe-in -68.4, 140.07 APE8-dihe-in -79.2, 65.9 APE8-rot-na 33.51 APE67-dihe-in -78.01, -3.3 -55.32, -41.07 APE12-dist-na 17.5147 APE11-dist-na 19.1062 APE10-dist-na 14.1547 APE9-dist-out 8.5977 L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 1.695 0.159 0.195 A 446.0 426.0 0 29 29 0 [[402, 653]] 1.0 4y93 Bos taurus TYR_BTK_BOVIN TYR 6.5e-93 316.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase
BTK Q3ZC95_BOVIN 4Y95B Q3ZC95 395 659 659.0 746:60701,PE4:60705 Type1,Allosteric Inactive DFGin 6.2838 14.0698 BLBplus -118.87, 151.9 58.51, 36.48 -63.81, 131.39 36.51, 95.01 77.72, -1.04 out-out out 14.5981 Saltbr-out 16.1022 HRD-in -74.38, -57.15 83.98, -6.38 out-out-out SNCooo out-out ActLoopNT-out 8.1264 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -110.28, -7.21 APE9-dihe-in -68.34, 135.25 APE8-dihe-in -80.18, 64.43 APE8-rot-na 29.96 APE67-dihe-in -80.41, -0.39 -53.51, -41.68 APE12-dist-na 17.4878 APE11-dist-na 18.9412 APE10-dist-na 13.9012 APE9-dist-out 8.7509 L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P None None XRAY 1.599 0.155 0.184 B 266.0 265.0 0 29 29 0 [[402, 653]] 1.0 4y95 Bos taurus TYR_BTK_BOVIN TYR 1.4e-93 318.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase
BTK Q3ZC95_BOVIN 4Y95C Q3ZC95 395 659 659.0 746:61001,PE4:61004 Type1,Allosteric Inactive DFGin 6.2611 14.0342 BLBplus -119.16, 152.8 57.59, 36.19 -63.2, 130.69 37.21, 95.75 78.07, -1.63 out-out out 14.6057 Saltbr-out 16.1522 HRD-in -74.98, -51.44 82.75, -9.25 out-out-out SNCooo out-out ActLoopNT-out 8.1038 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.01, -6.79 APE9-dihe-in -68.05, 136.6 APE8-dihe-in -80.31, 63.53 APE8-rot-na 30.49 APE67-dihe-in -79.73, -0.13 -53.01, -42.36 APE12-dist-na 17.506 APE11-dist-na 18.9727 APE10-dist-na 13.9266 APE9-dist-out 8.8005 L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P None None XRAY 1.599 0.155 0.184 C 266.0 265.0 0 29 29 0 [[402, 653]] 1.0 4y95 Bos taurus TYR_BTK_BOVIN TYR 1.4e-93 318.9 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase
BTK BTK_MOUSE 6MNYB P35991 395 656 659.0 No_ligand No_ligand Inactive DFGin 5.2333 13.7059 BLBplus -125.1, 165.75 52.84, 32.49 -58.38, 102.48 38.24, 93.39 84.1, 10.45 out-out out 15.3597 Saltbr-out 15.3618 HRD-in -76.61, -44.47 72.94, -21.5 out-out-none SNCoon out-none ActLoopNT-out 8.164 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.11 APE8-dihe-in -84.12, 99.31 APE8-rot-na 27.5 APE67-dihe-in -54.63, -7.98 -44.55, -71.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6525 None None None XRAY 2.8 0.199 0.257 B 276.0 253.0 9 29 20 9 [[402, 653]] 1.0 6mny Mus musculus TYR_BTK_MOUSE TYR 2.2e-92 315.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 4XI2A P35991 214 657 659.0 No_ligand No_ligand Inactive DFGin 6.073 13.6172 BLBplus -129.77, 176.3 55.32, 29.33 -68.82, 130.66 33.95, 96.53 79.95, -18.34 out-out out 16.133 Saltbr-out 15.266 HRD-in -76.78, -41.3 82.23, -28.62 out-out-out SNCooo out-out ActLoopNT-out 7.8601 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -123.97, 14.53 APE9-dihe-in -69.24, 140.86 APE8-dihe-in -65.55, 63.89 APE8-rot-na 337.2 APE67-dihe-in -72.94, -14.83 -61.29, -38.22 APE12-dist-na 16.7722 APE11-dist-na 18.9503 APE10-dist-na 14.481 APE9-dist-out 8.7636 None None None XRAY 2.6 0.231 0.248 A 446.0 421.0 0 29 29 0 [[402, 653]] 1.0 4xi2 Mus musculus TYR_BTK_MOUSE TYR 8.6e-92 313.2 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 8S93A P35991 1 659 659.0 9AJ:60701 Type1 Inactive DFGin 5.613 14.0422 BLBplus -138.68, 161.71 56.66, 47.49 -90.96, 127.53 49.22, 88.62 76.51, 0.36 out-none out 14.4956 Saltbr-none 999.0 HRD-in -85.34, -48.23 72.28, -3.13 none-out-out SNCnoo out-out ActLoopNT-out 8.0076 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -98.7, -4.82 APE9-dihe-in -69.1, 134.65 APE8-dihe-in -78.27, 78.56 APE8-rot-na 30.94 APE67-dihe-in -72.61, -7.52 -67.45, -38.51 APE12-dist-na 17.6112 APE11-dist-na 19.3217 APE10-dist-na 14.1247 APE9-dist-out 9.1621 Q91A,I92A,I94A,I95A,K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 2.1 0.201 0.246 A 457.0 422.0 0 29 29 0 [[402, 653]] 1.0 8s93 Mus musculus TYR_BTK_MOUSE TYR 5.9e-92 313.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 8GMBA P35991 214 659 659.0 9AJ:701 Type1 Inactive DFGin 5.509 12.6987 BLBplus -147.75, 172.59 51.29, 39.7 -66.24, 115.12 38.31, 84.34 67.51, 23.9 out-none out 16.0609 Saltbr-none 999.0 HRD-in -54.37, -39.85 77.19, -42.53 none-out-out SNCnoo out-out ActLoopNT-out 7.9557 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -78.99, 5.07 APE9-dihe-in -74.2, 132.98 APE8-dihe-in -77.72, 77.83 APE8-rot-na 351.22 APE67-dihe-in -56.74, -42.39 -65.52, -27.41 APE12-dist-na 17.4083 APE11-dist-na 19.2639 APE10-dist-na 14.5006 APE9-dist-out 9.5597 E298A,K300A,E301A,A384P,S386P,T387P,A388P,L390F,K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 3.4 0.273 0.289 A 659.0 438.0 0 29 29 0 [[402, 653]] 1.0 8gmb Mus musculus TYR_BTK_MOUSE TYR 1.4e-91 312.6 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 6MNYA P35991 395 656 659.0 JVP:701 Type1.5_Back Inactive DFGin 5.4078 13.4543 BLBplus -126.31, 164.74 54.03, 31.46 -57.89, 101.97 38.23, 93.33 85.13, 10.46 out-out out 15.0693 Saltbr-out 15.1381 HRD-in -77.46, -44.57 71.97, -19.22 out-out-out SNCooo out-out ActLoopNT-out 8.1773 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 2.74 APE9-dihe-in -82.84, 149.02 APE8-dihe-in -75.51, 71.13 APE8-rot-na 33.23 APE67-dihe-in -67.32, -6.29 -62.61, -44.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.5745 APE9-dist-out 9.2303 None None None XRAY 2.8 0.199 0.257 A 276.0 252.0 10 29 19 10 [[402, 653]] 1.0 6mny Mus musculus TYR_BTK_MOUSE TYR 2.2e-92 315.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 8FD9A P35991 396 659 659.0 XQQ:60801 Type1.5_Back Inactive DFGin 5.4245 13.8419 BLBplus -143.85, 171.16 60.8, 23.05 -58.7, 125.33 37.88, 85.05 75.51, 8.83 out-none out 15.044 Saltbr-none 999.0 HRD-in -74.88, -52.43 83.83, -11.3 none-out-out SNCnoo out-out ActLoopNT-out 7.722 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -104.17, 5.86 APE9-dihe-in -69.45, 141.3 APE8-dihe-in -71.5, 68.31 APE8-rot-na 27.11 APE67-dihe-in -75.09, -1.83 -59.51, -38.97 APE12-dist-na 16.7855 APE11-dist-na 19.0074 APE10-dist-na 14.1927 APE9-dist-out 8.6553 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 1.7 0.189 0.228 A 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 8fd9 Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 8FF0A P35991 396 659 659.0 7GB:60801 Type1.5_Back Inactive DFGin 5.2191 13.6773 BLBplus -132.25, 167.19 58.69, 27.63 -65.72, 123.75 35.91, 87.62 75.14, 19.75 out-none out 14.9533 Saltbr-none 999.0 HRD-in -69.37, -50.08 80.05, -16.38 none-out-out SNCnoo out-out ActLoopNT-out 7.7789 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.85, -26.74 APE9-dihe-in -55.22, 143.13 APE8-dihe-in -77.98, 65.87 APE8-rot-na 26.46 APE67-dihe-in -65.77, -20.77 -52.66, -49.09 APE12-dist-na 17.1354 APE11-dist-na 19.1037 APE10-dist-na 13.5458 APE9-dist-out 8.8625 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 2.6 0.242 0.267 A 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 8ff0 Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9EJXA P35991 396 659 659.0 A1BI1:60701 Type1.5_Back Inactive DFGin 5.364 13.4534 BLBplus -153.42, 172.61 57.75, 36.77 -82.82, 135.54 38.01, 92.52 69.8, 4.91 out-none out 14.6653 Saltbr-none 999.0 HRD-in -84.35, -55.61 84.23, -7.11 none-out-out SNCnoo out-out ActLoopNT-out 7.5531 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.32, 5.81 APE9-dihe-in -72.43, 137.34 APE8-dihe-in -77.97, 68.28 APE8-rot-na 30.72 APE67-dihe-in -70.58, -7.72 -58.08, -35.85 APE12-dist-na 16.4456 APE11-dist-na 18.506 APE10-dist-na 13.7176 APE9-dist-out 8.5004 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 2.86 0.264 0.296 A 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 9ejx Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9ME2A P35991 396 659 659.0 A1BKW:60701 Type1.5_Back Inactive DFGin 6.1761 13.862 BLBplus -153.57, 173.0 58.45, 37.1 -82.56, 135.76 37.63, 82.21 70.07, 5.04 out-none out 15.5031 Saltbr-none 999.0 HRD-in -83.6, -55.11 84.56, -6.48 none-out-out SNCnoo out-out ActLoopNT-out 7.8259 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -110.64, 5.72 APE9-dihe-in -72.11, 137.95 APE8-dihe-in -77.41, 68.47 APE8-rot-na 30.58 APE67-dihe-in -71.12, -7.96 -57.83, -36.21 APE12-dist-na 16.6386 APE11-dist-na 18.7398 APE10-dist-na 13.835 APE9-dist-out 8.7605 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 3.38 0.236 0.286 A 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 9me2 Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9ME3A P35991 396 659 659.0 A1BJE:60701 Type1.5_Back Inactive DFGin 5.2024 14.0765 BLBplus -154.07, 173.19 58.4, 37.61 -82.21, 135.41 37.94, 82.49 69.54, 4.73 out-none out 15.4183 Saltbr-none 999.0 HRD-in -84.92, -55.91 84.63, -7.62 none-out-out SNCnoo out-out ActLoopNT-out 7.6863 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.21, 5.41 APE9-dihe-in -72.58, 137.61 APE8-dihe-in -77.4, 68.82 APE8-rot-na 30.55 APE67-dihe-in -71.2, -8.1 -58.02, -36.38 APE12-dist-na 16.6269 APE11-dist-na 18.7046 APE10-dist-na 13.8611 APE9-dist-out 8.5836 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 3.05 0.228 0.288 A 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 9me3 Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9EJJA P35991 394 659 659.0 A1BIZ:701 Type1.5_Front Inactive DFGin 5.7614 13.6487 BLBplus -147.32, 173.09 58.85, 28.19 -76.07, 130.26 40.28, 86.74 72.63, 22.79 out-out out 15.3914 Saltbr-out 16.7212 HRD-in -81.76, -55.09 79.59, -6.11 out-out-out SNCooo out-out ActLoopNT-out 7.8703 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -88.9, -177.8 APE9-dihe-out -69.14, -44.42 APE8-dihe-out -58.97, -6.69 APE8-rot-na 334.43 APE67-dihe-in -64.23, -15.53 -59.83, -30.31 APE12-dist-na 999.0 APE11-dist-na 19.696 APE10-dist-na 15.0024 APE9-dist-out 11.0263 L390G,Y551E,Y617P None None XRAY 2.03 0.225 0.242 A 279.0 258.0 8 29 22 7 [[402, 653]] 1.0 9ejj Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9EJJB P35991 394 659 659.0 A1BIZ:701 Type1.5_Front Inactive DFGin 5.5008 14.0729 BLBplus -153.48, 175.7 63.93, 27.52 -79.9, 134.25 41.75, 85.89 73.22, 13.03 out-out out 16.4746 Saltbr-out 15.5152 HRD-in -79.13, -52.93 77.61, -0.8 out-out-out SNCooo out-out ActLoopNT-out 7.9037 ActLoopCT-out TYR APEdihe_iooai APEdist_aaao APE10-dihe-in -93.15, 172.37 APE9-dihe-out -61.71, -38.19 APE8-dihe-out -62.73, -3.38 APE8-rot-na 336.57 APE67-dihe-in -68.39, -9.76 -59.68, -31.05 APE12-dist-na 999.0 APE11-dist-na 19.4777 APE10-dist-na 14.5039 APE9-dist-out 10.8675 L390G,Y551E,Y617P None None XRAY 2.03 0.225 0.242 B 279.0 256.0 10 29 21 8 [[402, 653]] 1.0 9ejj Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9EJRA P35991 394 659 659.0 A1BI0:701 Type1.5_Front Inactive DFGin 5.9148 13.6438 BLBplus -146.74, 166.14 62.28, 23.66 -68.17, 124.47 38.27, 88.12 78.54, 14.19 out-out out 15.6993 Saltbr-out 15.7409 HRD-in -72.31, -57.13 80.67, 0.3 out-out-out SNCooo out-out ActLoopNT-out 7.8158 ActLoopCT-out TYR APEdihe_iooai APEdist_aaao APE10-dihe-in -92.94, 175.88 APE9-dihe-out -65.52, -38.77 APE8-dihe-out -63.32, -1.31 APE8-rot-na 335.74 APE67-dihe-in -69.18, -9.94 -59.0, -31.83 APE12-dist-na 21.4888 APE11-dist-na 20.0612 APE10-dist-na 15.1372 APE9-dist-out 11.1199 L390G,Y551E,Y617P None None XRAY 2.1 0.25 0.295 A 279.0 260.0 6 29 23 6 [[402, 653]] 1.0 9ejr Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9EJRB P35991 394 659 659.0 A1BI0:701 Type1.5_Front Inactive DFGin 5.5791 14.023 BLBplus -146.82, 168.57 65.02, 26.83 -69.27, 132.22 36.8, 90.68 70.75, 10.33 out-out out 16.1259 Saltbr-out 17.3767 HRD-in -76.4, -57.97 82.93, -6.46 out-out-out SNCooo out-out ActLoopNT-out 7.8983 ActLoopCT-out TYR APEdihe_iooai APEdist_aaao APE10-dihe-in -73.95, 158.19 APE9-dihe-out -60.45, -36.51 APE8-dihe-out -63.06, -4.13 APE8-rot-na 335.95 APE67-dihe-in -67.11, -17.18 -54.59, -31.21 APE12-dist-na 999.0 APE11-dist-na 19.985 APE10-dist-na 13.9759 APE9-dist-out 10.8815 L390G,Y551E,Y617P None None XRAY 2.1 0.25 0.295 B 279.0 256.0 10 29 21 8 [[402, 653]] 1.0 9ejr Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9EJSA P35991 396 659 659.0 A1BI0:60701 Type1.5_Front Inactive DFGin 6.0971 14.0929 BLBplus -154.67, 173.53 58.61, 37.48 -82.66, 135.95 37.6, 82.44 70.22, 5.22 out-none out 15.4292 Saltbr-none 999.0 HRD-in -84.8, -55.83 84.5, -7.48 none-out-out SNCnoo out-out ActLoopNT-out 8.1013 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -110.34, 5.15 APE9-dihe-in -73.07, 137.61 APE8-dihe-in -77.55, 68.34 APE8-rot-na 30.59 APE67-dihe-in -71.3, -7.86 -58.39, -36.7 APE12-dist-na 16.6634 APE11-dist-na 18.5815 APE10-dist-na 13.5366 APE9-dist-out 8.4696 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 2.26 0.194 0.246 A 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 9ejs Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9EJSB P35991 396 659 659.0 A1BI0:60701 Type1.5_Front Inactive DFGin 5.6865 14.0361 BLBplus -156.42, 172.76 60.49, 20.29 -63.05, 132.72 45.29, 85.58 77.61, -1.77 out-none out 15.2245 Saltbr-none 999.0 HRD-in -73.66, -56.25 84.42, -8.07 none-out-out SNCnoo out-out ActLoopNT-out 7.6221 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -122.47, 7.16 APE9-dihe-in -70.4, 144.43 APE8-dihe-in -80.98, 77.13 APE8-rot-na 29.28 APE67-dihe-in -72.16, -5.06 -62.4, -44.39 APE12-dist-na 16.6362 APE11-dist-na 18.7295 APE10-dist-na 13.8692 APE9-dist-out 8.6443 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 2.26 0.194 0.246 B 271.0 262.0 2 29 29 0 [[402, 653]] 1.0 9ejs Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 9EJSC P35991 396 659 659.0 A1BI0:60701 Type1.5_Front Inactive DFGin 5.7359 13.805 BLBplus -149.75, 171.22 61.78, 31.3 -76.97, 128.5 43.86, 90.23 72.89, 21.93 out-none out 14.9579 Saltbr-none 999.0 HRD-in -89.58, -48.29 82.25, -17.58 none-out-out SNCnoo out-out ActLoopNT-out 7.8728 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -125.95, 7.94 APE9-dihe-in -72.64, 139.26 APE8-dihe-in -74.43, 65.15 APE8-rot-na 26.63 APE67-dihe-in -70.23, -10.99 -55.69, -40.73 APE12-dist-na 16.965 APE11-dist-na 18.7295 APE10-dist-na 13.8121 APE9-dist-out 8.5488 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 2.26 0.194 0.246 C 271.0 264.0 0 29 29 0 [[402, 653]] 1.0 9ejs Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 8S9FA P35991 392 659 659.0 1N1:801 Type1 Inactive DFGinter 9.7383 8.4773 BABtrans -103.75, 162.9 -98.62, -12.56 -74.46, 134.73 203.6, 82.29 75.53, 30.46 out-out out 11.3245 Saltbr-out 8.457 HRD-out -78.16, 120.76 -71.26, -27.71 out-out-none SNCoon out-none ActLoopNT-out 5.4638 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 89.3 APE8-rot-na 354.27 APE67-dihe-in -88.28, 1.83 -66.03, -37.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 L390G,Y551E,Y617P None None XRAY 2.6 0.244 0.284 A 279.0 254.0 14 29 15 14 [[402, 653]] 1.0 8s9f Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
BTK BTK_MOUSE 8S9FB P35991 392 659 659.0 1N1:801 Type1 Inactive DFGinter 9.5087 8.4716 BABtrans -108.61, 149.63 -109.15, 7.92 -82.22, 131.91 185.43, 98.64 78.7, 27.48 out-out out 11.0192 Saltbr-out 10.3295 HRD-out -91.58, 112.75 -69.14, -29.29 out-out-out SNCooo out-out ActLoopNT-out 5.6813 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 166.92 APE9-dihe-in -91.32, 115.75 APE8-dihe-in -71.7, 107.6 APE8-rot-na 25.58 APE67-dihe-in -83.25, -12.58 -54.13, -30.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 16.1492 APE9-dist-out 18.604 L390G,Y551E,Y617P None None XRAY 2.6 0.244 0.284 B 279.0 255.0 13 29 17 12 [[402, 653]] 1.0 8s9f Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK