Activity: Pseudo (pseudokinase)

Total number of chains: 249
Active chains: 0
Total number of genes: 28
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 109 43.8% 8BA3A
DFGin BLAminus 50 20.1% 9M6GA
DFGin BLBplus 31 12.4% 7JURB
DFGinter None 15 6.0% 9D5IA
DFGin BLBminus 13 5.2% 9QTUA
DFGin ABAminus 11 4.4% 1TKIA
None None 11 4.4% 7BL1CCC
DFGin BLAplus 3 1.2% 7JXUA
DFGout BBAminus 3 1.2% 6VG3A
DFGout None 2 0.8% 6O5ZB
DFGin BLBtrans 1 0.4% 9BCPB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK CASK CSKP_HUMAN 3MFRA O14936 5 306 926.0 ANP:500 ATPlike Pseudo DFGin 7.288 14.824 BLAminus -130.01, -163.55 44.45, 79.28 -92.76, 26.16 280.97, 75.37 -59.27, -25.64 in-in in 9.502 Saltbr-in 2.799 HRD-in -78.83, -45.71 73.64, -1.18 in-in-in SNCiii in-in ActLoopNT-in 2.998 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.41, 141.74 APE9-dihe-na 116.11, -155.43 APE8-dihe-in -114.21, 120.95 APE8-rot-in 305.84 APE67-dihe-in -66.35, -20.44 -39.68, -44.71 APE12-dist-in 11.987 APE11-dist-in 12.403 APE10-dist-in 6.658 APE9-dist-in 3.593 P22A,H145E,C146N,G162D None None XRAY 2.0 0.198 0.241 A 351 302 0 0 0 0 [[12, 276]] 1.0 3mfr CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3MFSA O14936 4 306 926.0 ANP:500 ATPlike Pseudo DFGin 7.121 14.917 BLAminus -132.54, -159.47 54.72, 71.28 -90.49, 27.88 285.64, 73.35 -63.01, -24.88 in-in in 9.855 Saltbr-in 3.256 HRD-in -74.69, -45.24 69.87, -1.37 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.15, 142.33 APE9-dihe-na 119.56, -149.24 APE8-dihe-in -110.99, 115.07 APE8-rot-in 303.42 APE67-dihe-in -55.02, -32.56 -38.77, -44.89 APE12-dist-in 12.085 APE11-dist-in 12.3 APE10-dist-in 6.637 APE9-dist-in 3.634 P22A,H145E,C146N,G162D None None XRAY 2.1 0.221 0.268 A 351 303 0 0 0 0 [[12, 276]] 1.0 3mfs CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3MFUA O14936 5 306 926.0 ANP:500 ATPlike Pseudo DFGin 7.162 14.979 BLAminus -132.46, -169.21 51.97, 75.16 -95.02, 30.45 283.47, 72.96 -64.45, -32.11 in-in in 9.439 Saltbr-in 3.206 HRD-in -76.17, -45.52 71.72, -5.88 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.79, 142.93 APE9-dihe-na 117.49, -160.73 APE8-dihe-in -102.18, 121.4 APE8-rot-in 298.46 APE67-dihe-in -63.89, -19.89 -44.81, -44.73 APE12-dist-in 12.084 APE11-dist-in 12.195 APE10-dist-in 6.449 APE9-dist-in 3.737 P22A,H145E,C146N,G162D None None XRAY 2.3 0.182 0.234 A 351 302 0 0 0 0 [[12, 276]] 1.0 3mfu CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 9M6GA O14936 5 312 926.0 ANP:401 ATPlike Pseudo DFGin 7.452 15.114 BLAminus -123.77, -152.06 75.54, 37.97 -87.68, 22.87 280.47, 84.05 -71.57, -12.61 in-in in 9.6 Saltbr-in 2.897 HRD-in -79.25, -45.64 76.25, -8.72 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.23, 151.66 APE9-dihe-na 106.36, -155.68 APE8-dihe-in -120.97, 120.76 APE8-rot-in 297.98 APE67-dihe-in -62.79, -20.16 -47.6, -44.68 APE12-dist-in 12.42 APE11-dist-in 12.215 APE10-dist-in 6.65 APE9-dist-in 3.645 None None None XRAY 1.7 0.167 0.187 A 325 308 0 0 0 0 [[12, 276]] 1.0 9m6g CAMK_CASK_HUMAN CAMK 4.9e-82 281.1 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 9M5YA O14936 3 312 926.0 ANP:401 ATPlike Pseudo DFGin 7.714 15.512 BLAminus -121.67, -150.51 71.79, 35.46 -86.15, 22.59 279.83, 82.24 -67.65, -16.3 in-in in 9.959 Saltbr-in 2.867 HRD-in -79.78, -48.63 75.37, -2.97 in-in-in SNCiii in-in ActLoopNT-in 3.012 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.65, 147.9 APE9-dihe-na 109.7, -155.33 APE8-dihe-in -121.16, 120.88 APE8-rot-in 298.99 APE67-dihe-in -58.84, -21.41 -46.45, -46.8 APE12-dist-in 12.687 APE11-dist-in 12.279 APE10-dist-in 6.857 APE9-dist-in 3.592 None None None XRAY 1.8 0.168 0.197 A 338 310 0 0 0 0 [[12, 276]] 1.0 9m5y CAMK_CASK_HUMAN CAMK 5.6e-82 280.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3C0HA O14936 5 304 926.0 AMP:338 ATPlike Pseudo DFGin 7.602 15.272 BLAminus -127.83, -151.84 62.45, 48.02 -88.8, 12.97 279.71, 88.33 -53.45, -27.37 in-in in 9.984 Saltbr-in 3.32 HRD-in -71.81, -47.22 72.01, -10.53 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.88, 145.94 APE9-dihe-na 100.98, -162.69 APE8-dihe-in -107.97, 118.32 APE8-rot-in 308.41 APE67-dihe-in -60.72, -23.96 -42.45, -43.89 APE12-dist-in 13.036 APE11-dist-in 12.314 APE10-dist-in 6.82 APE9-dist-in 3.701 None None None XRAY 2.3 0.191 0.239 A 351 300 0 0 0 0 [[12, 276]] 1.0 3c0h CAMK_CASK_HUMAN CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3C0HB O14936 5 304 926.0 AMP:338 ATPlike Pseudo DFGin 7.6 15.203 BLAminus -120.68, -148.62 53.86, 55.42 -94.09, 23.7 283.84, 83.03 -57.86, -26.99 in-in in 9.535 Saltbr-in 3.011 HRD-in -71.85, -49.31 73.45, -6.5 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.66, 151.11 APE9-dihe-na 98.76, -158.5 APE8-dihe-in -113.67, 120.11 APE8-rot-in 310.97 APE67-dihe-in -61.76, -24.04 -43.49, -43.68 APE12-dist-in 12.992 APE11-dist-in 12.203 APE10-dist-in 6.64 APE9-dist-in 3.716 None None None XRAY 2.3 0.191 0.239 B 351 300 0 0 0 0 [[12, 276]] 1.0 3c0h CAMK_CASK_HUMAN CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3MFTA O14936 5 306 926.0 No_ligand No_ligand Pseudo DFGin 7.292 14.834 BLAminus -131.32, -156.93 44.41, 78.42 -93.33, 28.62 283.5, 69.48 -53.43, -36.46 in-in in 9.413 Saltbr-in 2.791 HRD-in -75.72, -50.07 74.15, 5.93 in-in-in SNCiii in-in ActLoopNT-in 3.038 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.73, 139.71 APE9-dihe-na 123.53, -152.17 APE8-dihe-in -117.17, 118.77 APE8-rot-in 308.79 APE67-dihe-in -61.5, -22.26 -37.69, -50.03 APE12-dist-in 12.268 APE11-dist-in 12.181 APE10-dist-in 6.364 APE9-dist-in 3.608 P22A,H145E,C146N,G162D None None XRAY 2.2 0.214 0.27 A 351 302 0 0 0 0 [[12, 276]] 1.0 3mft CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 6KMHA O14936 5 318 926.0 No_ligand No_ligand Pseudo DFGin 7.083 16.159 BLAminus -123.3, -153.22 66.24, 45.44 -87.94, 23.97 285.47, 87.97 -59.86, -25.49 out-in out 10.172 Saltbr-in 2.752 HRD-in -83.12, -49.07 74.39, -8.24 in-in-in SNCiii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.22, 147.02 APE9-dihe-na 100.62, -151.8 APE8-dihe-in -117.26, 118.55 APE8-rot-in 310.89 APE67-dihe-in -65.56, -17.16 -41.82, -48.34 APE12-dist-in 12.295 APE11-dist-in 12.037 APE10-dist-in 6.476 APE9-dist-in 3.927 None None None XRAY 2.4 0.19 0.224 A 325 314 0 0 0 0 [[12, 276]] 1.0 6kmh CAMK_CASK_HUMAN CAMK 4.9e-82 281.1 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 6KMHB O14936 5 319 926.0 No_ligand No_ligand Pseudo DFGin 7.466 16.082 BLAminus -119.05, -153.46 64.87, 44.2 -87.52, 21.7 281.92, 86.46 -59.52, -24.1 out-in out 10.255 Saltbr-in 3.118 HRD-in -83.29, -47.47 74.84, -8.44 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.47, 146.66 APE9-dihe-na 101.89, -151.28 APE8-dihe-in -117.25, 119.53 APE8-rot-in 313.99 APE67-dihe-in -66.53, -18.26 -39.52, -48.38 APE12-dist-in 12.389 APE11-dist-in 12.168 APE10-dist-in 6.592 APE9-dist-in 3.75 None None None XRAY 2.4 0.19 0.224 B 325 315 0 0 0 0 [[12, 276]] 1.0 6kmh CAMK_CASK_HUMAN CAMK 4.9e-82 281.1 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 8Y68A O14936 5 326 926.0 No_ligand No_ligand Pseudo DFGin 7.593 16.272 BLAminus -122.61, -155.23 66.8, 41.14 -86.85, 31.1 288.8, 86.07 -70.48, -25.66 out-in out 10.254 Saltbr-in 3.162 HRD-in -77.53, -51.01 74.47, 3.49 in-in-in SNCiii in-in ActLoopNT-in 3.057 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.69, 141.68 APE9-dihe-na 112.97, -158.9 APE8-dihe-in -109.43, 127.51 APE8-rot-in 305.09 APE67-dihe-in -63.9, -19.3 -52.54, -41.88 APE12-dist-in 12.447 APE11-dist-in 12.496 APE10-dist-in 6.811 APE9-dist-in 3.643 None None None XRAY 2.2 0.239 0.264 A 338 314 0 0 0 0 [[12, 276]] 1.0 8y68 CAMK_CASK_HUMAN CAMK 5.6e-82 280.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 8Y68B O14936 5 326 926.0 No_ligand No_ligand Pseudo DFGin 7.601 16.256 BLAminus -125.55, -154.73 72.48, 30.93 -72.18, 9.57 291.2, 87.71 -53.49, -29.27 out-in out 10.315 Saltbr-in 3.152 HRD-in -82.62, -50.05 72.74, 0.25 in-in-in SNCiii in-in ActLoopNT-in 3.049 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.07, 135.76 APE9-dihe-na 113.27, -153.29 APE8-dihe-in -109.51, 129.79 APE8-rot-in 312.74 APE67-dihe-in -65.56, -15.72 -52.48, -42.69 APE12-dist-in 12.273 APE11-dist-in 12.386 APE10-dist-in 6.81 APE9-dist-in 3.76 None None None XRAY 2.2 0.239 0.264 B 338 314 0 0 0 0 [[12, 276]] 1.0 8y68 CAMK_CASK_HUMAN CAMK 5.6e-82 280.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3TACA O14936 1 316 926.0 No_ligand No_ligand Pseudo DFGin 6.944 16.058 BLAminus -118.76, -153.24 70.18, 38.72 -82.45, 19.1 280.36, 87.78 -61.94, -22.6 in-in in 9.898 Saltbr-in 2.771 HRD-in -76.74, -44.98 69.76, -3.53 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.01, 154.44 APE9-dihe-na 104.4, -155.75 APE8-dihe-in -114.86, 120.22 APE8-rot-in 318.17 APE67-dihe-in -58.84, -21.43 -38.04, -53.6 APE12-dist-in 11.348 APE11-dist-in 11.992 APE10-dist-in 6.111 APE9-dist-in 3.89 None None None XRAY 2.2 0.197 0.236 A 361 316 0 0 0 0 [[12, 276]] 1.0 3tac CAMK_CASK_HUMAN CAMK 6.9e-82 280.6 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3C0GA O14936 6 322 926.0 3AM:338 Type1 Pseudo DFGin 7.601 15.277 BLAminus -127.85, -156.96 71.55, 38.89 -83.99, 24.11 280.56, 90.68 -66.8, -16.25 in-in in 9.698 Saltbr-in 2.821 HRD-in -78.17, -49.52 75.88, -5.71 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.82, 145.93 APE9-dihe-na 104.74, -155.59 APE8-dihe-in -117.06, 121.65 APE8-rot-in 303.15 APE67-dihe-in -64.45, -28.84 -44.87, -37.97 APE12-dist-in 13.15 APE11-dist-in 12.427 APE10-dist-in 6.745 APE9-dist-in 3.762 None None None XRAY 2.19 0.211 0.27 A 351 309 0 0 0 0 [[12, 276]] 1.0 3c0g CAMK_CASK_HUMAN CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3C0GB O14936 5 324 926.0 3AM:338 Type1 Pseudo DFGin 7.633 15.073 BLAminus -125.12, -156.54 71.61, 45.27 -92.39, 28.47 288.78, 82.4 -64.66, -24.35 in-in in 9.558 Saltbr-in 2.945 HRD-in -76.2, -51.0 76.77, -9.71 in-in-in SNCiii in-in ActLoopNT-in 3.007 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.55, 151.02 APE9-dihe-na 96.93, -151.24 APE8-dihe-in -120.05, 124.04 APE8-rot-in 309.17 APE67-dihe-in -64.19, -30.47 -45.02, -40.93 APE12-dist-in 12.971 APE11-dist-in 12.094 APE10-dist-in 6.525 APE9-dist-in 3.814 None None None XRAY 2.19 0.211 0.27 B 351 320 0 0 0 0 [[12, 276]] 1.0 3c0g CAMK_CASK_HUMAN CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3C0IA O14936 6 303 926.0 3AM:338 Type1 Pseudo DFGin 7.764 15.227 BLAminus -126.8, -156.64 68.7, 42.73 -87.0, 18.63 278.58, 81.77 -64.01, -14.22 in-in in 9.672 Saltbr-in 2.605 HRD-in -80.62, -46.18 75.85, -2.66 in-in-in SNCiii in-in ActLoopNT-in 2.964 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.41, 154.48 APE9-dihe-na 101.89, -149.51 APE8-dihe-in -122.73, 125.07 APE8-rot-in 302.47 APE67-dihe-in -59.53, -20.3 -39.4, -52.94 APE12-dist-in 12.793 APE11-dist-in 12.642 APE10-dist-in 6.992 APE9-dist-in 3.661 None None None XRAY 1.85 0.185 0.234 A 351 298 0 0 0 0 [[12, 276]] 1.0 3c0i CAMK_CASK_HUMAN CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAIA O14936 5 303 926.0 V5W:401 Type1 Pseudo DFGin 7.298 15.163 BLAminus -133.41, -156.01 67.4, 52.14 -90.27, 23.73 279.32, 78.06 -61.92, -24.84 in-in in 9.754 Saltbr-in 2.741 HRD-in -85.46, -50.33 75.77, -0.65 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.24, 157.29 APE9-dihe-na 101.8, -156.26 APE8-dihe-in -123.19, 124.54 APE8-rot-in 306.52 APE67-dihe-in -62.48, -18.0 -44.03, -47.72 APE12-dist-in 12.271 APE11-dist-in 12.237 APE10-dist-in 6.616 APE9-dist-in 3.487 None None None XRAY 2.3 0.181 0.213 A 353 299 0 0 0 0 [[12, 276]] 1.0 7oai CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAIB O14936 5 303 926.0 V5W:401 Type1 Pseudo DFGin 7.406 15.259 BLAminus -134.47, -156.8 64.29, 54.6 -90.19, 20.71 279.7, 78.36 -59.98, -22.81 in-in in 9.646 Saltbr-in 2.755 HRD-in -82.86, -50.6 76.31, -2.1 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.62, 153.97 APE9-dihe-na 100.84, -154.73 APE8-dihe-in -124.35, 124.11 APE8-rot-in 306.98 APE67-dihe-in -62.09, -17.89 -45.97, -46.24 APE12-dist-in 12.157 APE11-dist-in 12.2 APE10-dist-in 6.647 APE9-dist-in 3.494 None None None XRAY 2.3 0.181 0.213 B 353 299 0 0 0 0 [[12, 276]] 1.0 7oai CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAIC O14936 5 303 926.0 V5W:401 Type1 Pseudo DFGin 7.266 15.199 BLAminus -133.92, -155.83 67.09, 52.18 -89.16, 22.87 280.57, 76.97 -63.32, -23.32 in-in in 9.745 Saltbr-in 2.737 HRD-in -85.91, -50.13 74.59, 1.73 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.86, 156.71 APE9-dihe-na 102.05, -154.78 APE8-dihe-in -124.05, 124.49 APE8-rot-in 307.2 APE67-dihe-in -62.05, -18.61 -44.79, -47.86 APE12-dist-in 12.322 APE11-dist-in 12.242 APE10-dist-in 6.631 APE9-dist-in 3.478 None None None XRAY 2.3 0.181 0.213 C 353 299 0 0 0 0 [[12, 276]] 1.0 7oai CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAID O14936 6 303 926.0 V5W:401 Type1 Pseudo DFGin 7.346 15.237 BLAminus -133.95, -155.79 64.33, 54.36 -89.82, 21.4 279.87, 77.78 -61.16, -23.41 in-in in 9.683 Saltbr-in 2.747 HRD-in -82.79, -50.35 76.19, -0.44 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.41, 155.17 APE9-dihe-na 102.2, -155.58 APE8-dihe-in -123.56, 124.71 APE8-rot-in 305.13 APE67-dihe-in -62.31, -17.38 -49.2, -45.27 APE12-dist-in 12.221 APE11-dist-in 12.209 APE10-dist-in 6.625 APE9-dist-in 3.501 None None None XRAY 2.3 0.181 0.213 D 353 298 0 0 0 0 [[12, 276]] 1.0 7oai CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAJA O14936 6 303 926.0 V6E:401 Type1 Pseudo DFGin 7.465 15.078 BLAminus -137.38, -156.31 67.0, 54.02 -98.23, 24.47 280.92, 80.01 -59.79, -27.2 in-in in 9.591 Saltbr-in 2.708 HRD-in -81.0, -50.68 73.69, 2.52 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.23, 155.45 APE9-dihe-na 103.39, -156.39 APE8-dihe-in -113.61, 120.06 APE8-rot-in 307.44 APE67-dihe-in -63.71, -17.6 -41.22, -47.31 APE12-dist-in 12.54 APE11-dist-in 12.395 APE10-dist-in 6.658 APE9-dist-in 3.555 None None None XRAY 1.93 0.196 0.224 A 353 298 0 0 0 0 [[12, 276]] 1.0 7oaj CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAJB O14936 6 302 926.0 V6E:401 Type1 Pseudo DFGin 7.475 15.079 BLAminus -137.94, -153.32 65.94, 55.26 -97.15, 23.72 281.55, 79.69 -61.84, -24.6 in-in in 9.72 Saltbr-in 2.724 HRD-in -77.62, -50.76 77.43, -1.23 in-in-in SNCiii in-in ActLoopNT-in 2.983 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.83, 154.2 APE9-dihe-na 101.54, -154.61 APE8-dihe-in -115.13, 119.42 APE8-rot-in 309.29 APE67-dihe-in -62.87, -17.76 -41.3, -48.63 APE12-dist-in 12.523 APE11-dist-in 12.327 APE10-dist-in 6.598 APE9-dist-in 3.578 None None None XRAY 1.93 0.196 0.224 B 353 297 0 0 0 0 [[12, 276]] 1.0 7oaj CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAJC O14936 6 302 926.0 V6E:401 Type1 Pseudo DFGin 7.497 15.179 BLAminus -136.41, -160.63 72.01, 54.76 -99.05, 24.93 280.01, 78.43 -62.46, -24.7 in-in in 9.647 Saltbr-in 2.628 HRD-in -80.82, -50.61 76.79, -1.71 in-in-in SNCiii in-in ActLoopNT-in 2.97 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.6, 154.39 APE9-dihe-na 106.94, -159.9 APE8-dihe-in -112.12, 120.81 APE8-rot-in 308.21 APE67-dihe-in -62.82, -18.27 -42.55, -47.05 APE12-dist-in 12.485 APE11-dist-in 12.24 APE10-dist-in 6.525 APE9-dist-in 3.625 None None None XRAY 1.93 0.196 0.224 C 353 297 0 0 0 0 [[12, 276]] 1.0 7oaj CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAJD O14936 6 302 926.0 V6E:401 Type1 Pseudo DFGin 7.454 15.113 BLAminus -138.17, -158.23 72.25, 54.22 -97.74, 24.82 282.66, 79.21 -59.78, -28.02 in-in in 9.571 Saltbr-in 2.708 HRD-in -80.07, -50.29 76.16, -3.37 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.41, 154.37 APE9-dihe-na 101.1, -156.72 APE8-dihe-in -114.39, 120.47 APE8-rot-in 308.84 APE67-dihe-in -63.16, -18.07 -42.13, -47.71 APE12-dist-in 12.304 APE11-dist-in 12.223 APE10-dist-in 6.557 APE9-dist-in 3.558 None None None XRAY 1.93 0.196 0.224 D 353 297 0 0 0 0 [[12, 276]] 1.0 7oaj CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAKA O14936 6 303 926.0 V6B:401 Type1 Pseudo DFGin 7.304 15.228 BLAminus -130.41, -157.06 61.37, 61.32 -91.79, 25.13 281.33, 80.97 -69.94, -28.17 in-in in 9.527 Saltbr-in 2.841 HRD-in -76.13, -51.85 74.61, -3.02 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.67, 153.74 APE9-dihe-na 106.78, -159.33 APE8-dihe-in -112.37, 122.83 APE8-rot-in 314.55 APE67-dihe-in -61.67, -20.43 -41.39, -48.02 APE12-dist-in 12.319 APE11-dist-in 12.328 APE10-dist-in 6.584 APE9-dist-in 3.562 None None None XRAY 2.23 0.225 0.264 A 353 298 0 0 0 0 [[12, 276]] 1.0 7oak CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAKB O14936 6 303 926.0 V6B:401 Type1 Pseudo DFGin 7.336 15.227 BLAminus -131.36, -157.62 62.2, 60.25 -91.91, 25.95 281.51, 81.91 -68.27, -29.14 in-in in 9.509 Saltbr-in 2.855 HRD-in -76.03, -51.92 74.46, -2.99 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.76, 153.77 APE9-dihe-na 102.84, -159.79 APE8-dihe-in -112.51, 123.0 APE8-rot-in 313.12 APE67-dihe-in -62.19, -20.22 -42.06, -47.29 APE12-dist-in 12.257 APE11-dist-in 12.353 APE10-dist-in 6.625 APE9-dist-in 3.57 None None None XRAY 2.23 0.225 0.264 B 353 298 0 0 0 0 [[12, 276]] 1.0 7oak CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAKC O14936 6 303 926.0 V6B:401 Type1 Pseudo DFGin 7.434 15.302 BLAminus -132.96, -154.64 59.24, 62.07 -91.24, 25.15 282.78, 81.78 -68.83, -28.66 in-in in 9.561 Saltbr-in 2.832 HRD-in -74.19, -52.11 73.81, -2.72 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.28, 151.79 APE9-dihe-na 99.61, -159.19 APE8-dihe-in -113.41, 122.44 APE8-rot-in 312.66 APE67-dihe-in -61.94, -19.16 -40.72, -48.09 APE12-dist-in 11.971 APE11-dist-in 12.236 APE10-dist-in 6.56 APE9-dist-in 3.558 None None None XRAY 2.23 0.225 0.264 C 353 298 0 0 0 0 [[12, 276]] 1.0 7oak CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAKD O14936 6 303 926.0 V6B:401 Type1 Pseudo DFGin 7.447 15.292 BLAminus -131.94, -156.09 61.73, 60.92 -90.98, 25.56 282.18, 81.16 -70.77, -27.17 in-in in 9.524 Saltbr-in 2.901 HRD-in -74.78, -52.28 74.18, -3.89 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.98, 151.69 APE9-dihe-na 100.58, -159.38 APE8-dihe-in -113.19, 122.81 APE8-rot-in 313.65 APE67-dihe-in -62.13, -19.35 -40.85, -48.69 APE12-dist-in 11.978 APE11-dist-in 12.236 APE10-dist-in 6.558 APE9-dist-in 3.565 None None None XRAY 2.23 0.225 0.264 D 353 298 0 0 0 0 [[12, 276]] 1.0 7oak CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OALA O14936 6 303 926.0 V62:401 Type1 Pseudo DFGin 7.112 15.312 BLAminus -132.36, -163.43 72.61, 55.26 -90.57, 19.61 279.99, 83.99 -61.09, -29.25 in-in in 9.583 Saltbr-in 2.875 HRD-in -85.81, -52.33 77.93, -1.53 in-in-in SNCiii in-in ActLoopNT-in 2.975 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.96, 152.07 APE9-dihe-na 101.6, -159.85 APE8-dihe-in -110.2, 121.48 APE8-rot-in 312.05 APE67-dihe-in -65.42, -19.22 -48.15, -43.67 APE12-dist-in 12.21 APE11-dist-in 12.253 APE10-dist-in 6.434 APE9-dist-in 3.666 None None None XRAY 2.17 0.223 0.274 A 353 298 0 0 0 0 [[12, 276]] 1.0 7oal CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OALB O14936 6 303 926.0 V62:401 Type1 Pseudo DFGin 7.114 15.327 BLAminus -132.11, -163.12 72.34, 55.56 -91.3, 20.03 280.63, 83.48 -61.81, -28.8 in-in in 9.593 Saltbr-in 2.881 HRD-in -85.23, -52.63 77.44, -1.15 in-in-in SNCiii in-in ActLoopNT-in 2.978 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.35, 153.52 APE9-dihe-na 100.67, -161.1 APE8-dihe-in -109.69, 122.34 APE8-rot-in 310.81 APE67-dihe-in -65.02, -19.58 -48.89, -43.47 APE12-dist-in 12.242 APE11-dist-in 12.28 APE10-dist-in 6.451 APE9-dist-in 3.641 None None None XRAY 2.17 0.223 0.274 B 353 298 0 0 0 0 [[12, 276]] 1.0 7oal CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OALC O14936 6 303 926.0 V62:401 Type1 Pseudo DFGin 7.316 15.302 BLAminus -133.03, -162.78 73.8, 55.36 -91.46, 20.34 280.91, 83.96 -61.1, -29.26 in-in in 9.501 Saltbr-in 2.866 HRD-in -82.75, -52.35 77.06, -0.71 in-in-in SNCiii in-in ActLoopNT-in 2.971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.29, 153.25 APE9-dihe-na 102.82, -161.36 APE8-dihe-in -109.75, 121.57 APE8-rot-in 312.81 APE67-dihe-in -65.06, -20.51 -46.72, -44.72 APE12-dist-in 12.1 APE11-dist-in 12.191 APE10-dist-in 6.382 APE9-dist-in 3.654 None None None XRAY 2.17 0.223 0.274 C 353 298 0 0 0 0 [[12, 276]] 1.0 7oal CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OALD O14936 6 303 926.0 V62:401 Type1 Pseudo DFGin 7.274 15.233 BLAminus -132.5, -163.17 74.68, 55.23 -92.62, 20.5 281.05, 84.43 -61.57, -28.44 in-in in 9.515 Saltbr-in 2.886 HRD-in -83.05, -52.0 77.0, 0.16 in-in-in SNCiii in-in ActLoopNT-in 2.988 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.95, 153.91 APE9-dihe-na 103.44, -161.31 APE8-dihe-in -109.94, 121.75 APE8-rot-in 312.38 APE67-dihe-in -65.52, -20.47 -47.78, -43.72 APE12-dist-in 12.152 APE11-dist-in 12.238 APE10-dist-in 6.398 APE9-dist-in 3.67 None None None XRAY 2.17 0.223 0.274 D 353 298 0 0 0 0 [[12, 276]] 1.0 7oal CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK STK40 STK40_HUMAN 5L2QA Q8N2I9 26 336 435.0 No_ligand No_ligand Pseudo DFGin 7.114 14.956 BLAminus -130.47, 179.73 54.86, 74.12 -97.26, 23.85 290.91, 75.33 -74.09, -21.88 in-in in 7.297 Saltbr-in 2.909 HRD-in -73.02, -40.2 65.84, 10.35 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.56, 165.42 APE9-dihe-na 143.21, -167.32 APE8-dihe-in -94.13, 140.21 APE8-rot-in 306.65 APE67-dihe-in -86.95, -21.7 -64.41, -20.42 APE12-dist-in 8.232 APE11-dist-in 11.512 APE10-dist-in 6.533 APE9-dist-in 4.186 None None None XRAY 2.53 0.259 0.28 A 320 293 18 0 0 0 [[35, 328]] 1.0 5l2q CAMK_STK40_HUMAN CAMK 8.5e-56 195.3 3 252 250 215 216 217 219 221 66 93 97 194 196 195 197 256 243 238 237 236 235 234 233 232 142 Serine/threonine-protein kinase 40
CAMK STK40 STK40_HUMAN 5L2QB Q8N2I9 30 336 435.0 No_ligand No_ligand Pseudo DFGin 6.965 15.349 BLAminus -131.07, 171.22 59.14, 69.59 -85.39, 7.72 279.35, 77.7 -62.69, 161.76 in-none in 7.857 Saltbr-none 999.0 HRD-in -72.7, -41.34 64.76, 5.09 none-in-in SNCnii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.99, 164.94 APE9-dihe-na 135.93, -150.33 APE8-dihe-in -109.54, 129.83 APE8-rot-in 302.09 APE67-dihe-in -74.71, -21.69 -65.57, -29.17 APE12-dist-in 8.046 APE11-dist-in 11.887 APE10-dist-in 6.921 APE9-dist-in 4.563 None None None XRAY 2.53 0.259 0.28 B 320 282 25 0 0 0 [[35, 328]] 1.0 5l2q CAMK_STK40_HUMAN CAMK 8.5e-56 195.3 3 252 250 215 216 217 219 221 66 93 97 194 196 195 197 256 243 238 237 236 235 234 233 232 142 Serine/threonine-protein kinase 40
CAMK STK40 STK40_HUMAN 5L2QC Q8N2I9 37 335 435.0 No_ligand No_ligand Pseudo DFGin 7.092 15.039 BLAminus -133.56, -179.23 57.51, 64.69 -82.37, 26.05 290.35, 86.47 -68.29, -15.59 in-in in 7.66 Saltbr-in 3.277 HRD-in -83.98, -44.38 69.36, 10.0 in-in-in SNCiii in-in ActLoopNT-in 3.066 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.34, 179.97 APE9-dihe-na 140.29, -163.44 APE8-dihe-in -109.8, 138.42 APE8-rot-in 300.31 APE67-dihe-in -73.67, -24.36 -69.64, -28.68 APE12-dist-in 7.088 APE11-dist-in 10.908 APE10-dist-in 6.356 APE9-dist-in 4.174 None None None XRAY 2.53 0.259 0.28 C 320 282 19 0 0 0 [[35, 328]] 1.0 5l2q CAMK_STK40_HUMAN CAMK 8.5e-56 195.3 3 252 250 215 216 217 219 221 66 93 97 194 196 195 197 256 243 238 237 236 235 234 233 232 142 Serine/threonine-protein kinase 40
CAMK STK40 STK40_HUMAN 5L2QD Q8N2I9 30 336 435.0 No_ligand No_ligand Pseudo DFGin 7.252 16.006 BLAminus -120.21, 167.59 66.14, 61.69 -79.71, 21.58 270.92, 90.12 -59.45, 158.52 in-out in 8.082 Saltbr-out 3.644 HRD-in -71.64, -38.36 66.3, 3.21 out-in-out SNCoio in-out ActLoopNT-in 3.242 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -74.16, 173.54 APE9-dihe-na 143.3, -118.75 APE8-dihe-in -148.5, 125.34 APE8-rot-in 276.59 APE67-dihe-in -58.91, -57.22 -56.59, -40.18 APE12-dist-out 6.843 APE11-dist-in 11.068 APE10-dist-in 6.31 APE9-dist-in 4.288 None None None XRAY 2.53 0.259 0.28 D 320 294 13 0 0 0 [[35, 328]] 1.0 5l2q CAMK_STK40_HUMAN CAMK 8.5e-56 195.3 3 252 250 215 216 217 219 221 66 93 97 194 196 195 197 256 243 238 237 236 235 234 233 232 142 Serine/threonine-protein kinase 40
CAMK TRIB1 TRIB1_HUMAN 6DC0A Q96RU8 90 67 372.0 No_ligand No_ligand Pseudo DFGin 5.27 13.715 ABAminus -62.79, -39.34 -158.25, 143.44 -106.23, 4.19 300.38, 172.91 -43.04, -40.92 in-na in 7.854 Saltbr-na 999.0 HRD-in -77.3, -49.83 85.96, -38.94 na-in-out SNCaio in-out ActLoopNT-in 2.808 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioi APE10-dihe-na -136.64, 136.29 APE9-dihe-na 165.89, 172.66 APE8-dihe-in -80.09, 127.29 APE8-rot-na 164.01 APE67-dihe-in -56.98, -28.22 -49.22, -44.47 APE12-dist-in 9.678 APE11-dist-in 13.949 APE10-dist-out 9.257 APE9-dist-in 5.005 None None None XRAY 2.8 0.223 0.277 A 292 252 0 0 0 0 [[99, 338]] 1.0 6dc0 CAMK_TRIB1_HUMAN CAMK 1.3e-61 214.2 14 256 243 224 225 226 228 230 120 130 134 202 204 203 205 266 252 247 246 245 244 243 242 241 161 Tribbles homolog 1
CAMK TRIB1 TRIB1_HUMAN 6DC0B Q96RU8 90 74 372.0 No_ligand No_ligand Pseudo DFGin 5.352 13.828 ABAminus -62.01, -39.54 -159.17, 144.16 -104.11, 2.82 300.43, 173.55 -43.43, -39.53 in-na in 7.86 Saltbr-na 999.0 HRD-in -77.34, -49.74 84.82, -39.13 na-in-out SNCaio in-out ActLoopNT-in 2.806 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioi APE10-dihe-na -137.93, 136.24 APE9-dihe-na 164.23, 174.07 APE8-dihe-in -80.22, 127.97 APE8-rot-na 166.15 APE67-dihe-in -57.45, -28.66 -52.5, -42.66 APE12-dist-in 9.954 APE11-dist-in 13.924 APE10-dist-out 9.089 APE9-dist-in 4.988 None None None XRAY 2.8 0.223 0.277 B 292 249 4 0 0 0 [[99, 338]] 1.0 6dc0 CAMK_TRIB1_HUMAN CAMK 1.3e-61 214.2 14 256 243 224 225 226 228 230 120 130 134 202 204 203 205 266 252 247 246 245 244 243 242 241 161 Tribbles homolog 1
CAMK TRIB1 TRIB1_HUMAN 5CEKA Q96RU8 88 342 372.0 No_ligand No_ligand Pseudo DFGinter 8.858 7.037 None -98.32, 87.14 -82.08, -7.36 -109.34, 16.03 300.0, 168.59 61.59, 55.88 out-na out 12.089 Saltbr-na 999.0 HRD-in -75.72, -58.41 87.17, -43.21 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 124.18 APE8-rot-na 59.79 APE67-dihe-out 80.81, -50.83 -77.85, -164.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.209 0.246 A 263 237 18 0 0 13 [[99, 338]] 1.0 5cek CAMK_TRIB1_HUMAN CAMK 8.9e-62 214.7 14 256 243 224 225 226 228 230 120 130 134 202 204 203 205 266 252 247 246 245 244 243 242 241 161 Tribbles homolog 1
CAMK TRIB1 TRIB1_HUMAN 5CEMA Q96RU8 88 364 372.0 No_ligand No_ligand Pseudo DFGinter 9.487 6.83 None -85.06, 104.77 -111.16, 5.29 -105.21, 15.47 300.28, 1.5 60.7, 52.63 out-na out 12.027 Saltbr-na 999.0 HRD-in -82.52, -54.12 78.21, -13.8 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_oooo APE10-dihe-na -58.19, 148.96 APE9-dihe-na 66.07, 47.38 APE8-dihe-in -82.13, 123.37 APE8-rot-na 180.29 APE67-dihe-out -72.24, -16.3 -74.98, 72.26 APE12-dist-out 26.802 APE11-dist-out 24.692 APE10-dist-out 20.205 APE9-dist-out 15.941 None None None XRAY 2.1 0.179 0.223 A 292 252 11 0 0 9 [[99, 338]] 1.0 5cem CAMK_TRIB1_HUMAN CAMK 1.3e-61 214.2 14 256 243 224 225 226 228 230 120 130 134 202 204 203 205 266 252 247 246 245 244 243 242 241 161 Tribbles homolog 1
CAMK TRIB2 TRIB2_HUMAN 7UPMA Q92519 55 312 343.0 No_ligand No_ligand Pseudo DFGin 4.905 14.44 ABAminus -58.01, -48.87 -164.7, 172.09 -114.04, 14.33 303.11, 167.65 -48.53, -44.56 in-na in 9.588 Saltbr-na 999.0 HRD-in -81.23, -42.97 77.99, -33.0 na-in-out SNCaio in-out ActLoopNT-in 2.874 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -129.77, 155.01 APE9-dihe-na 130.76, 152.14 APE8-dihe-in -71.56, 130.0 APE8-rot-na 194.78 APE67-dihe-in -65.79, -28.93 -44.49, -39.77 APE12-dist-in 12.62 APE11-dist-out 15.279 APE10-dist-out 9.734 APE9-dist-in 3.727 None None None XRAY 2.7 0.207 0.26 A 264 258 0 0 0 0 [[64, 308]] 1.0 7upm CAMK_TRIB2_HUMAN CAMK 2.3e-61 213.3 14 256 243 194 195 196 198 200 90 100 104 172 174 173 175 236 222 217 216 215 214 213 212 211 131 Tribbles homolog 2
CAMK TTN TITIN_HUMAN 1TKIA Q8WZ42 32172 32492 34350.0 No_ligand No_ligand Pseudo DFGin 6.649 15.225 ABAminus -105.41, -5.26 -111.51, 126.72 -141.0, 22.89 293.99, 87.75 -67.88, -14.18 out-out out 11.004 Saltbr-out 4.917 HRD-in -83.05, -52.59 67.65, 9.17 out-in-out SNCoio in-out ActLoopNT-in 2.887 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioo APE10-dihe-na -163.08, 161.44 APE9-dihe-na -126.55, -21.86 APE8-dihe-in -112.32, 91.87 APE8-rot-none 999.0 APE67-dihe-in -57.33, -25.65 -56.87, -32.42 APE12-dist-in 7.36 APE11-dist-in 8.076 APE10-dist-out 10.434 APE9-dist-out 10.328 None None None XRAY 2.0 0.207 0.248 A 321 321 0 0 0 0 [[32178, 32432]] 1.0 1tki CAMK_TTN_HUMAN CAMK 1.3e-78 270.0 1 256 256 32317 32318 32319 32321 32323 32207 32222 32226 32295 32297 32296 32298 32356 32344 32339 32338 32337 32336 32335 32334 32333 32252 Titin
CAMK TTN TITIN_HUMAN 1TKIB Q8WZ42 32172 32492 34350.0 No_ligand No_ligand Pseudo DFGin 6.648 15.22 ABAminus -105.18, -5.09 -111.75, 126.64 -140.7, 22.72 294.32, 87.47 -67.75, -13.65 out-out out 11.0 Saltbr-out 4.928 HRD-in -83.59, -52.58 67.17, 9.67 out-in-out SNCoio in-out ActLoopNT-in 2.888 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioo APE10-dihe-na -162.93, 161.49 APE9-dihe-na -126.47, -22.28 APE8-dihe-in -112.04, 92.34 APE8-rot-none 999.0 APE67-dihe-in -57.51, -25.32 -56.86, -32.43 APE12-dist-in 7.367 APE11-dist-in 8.079 APE10-dist-out 10.434 APE9-dist-out 10.324 None None None XRAY 2.0 0.207 0.248 B 321 321 0 0 0 0 [[32178, 32432]] 1.0 1tki CAMK_TTN_HUMAN CAMK 1.3e-78 270.0 1 256 256 32317 32318 32319 32321 32323 32207 32222 32226 32295 32297 32296 32298 32356 32344 32339 32338 32337 32336 32335 32334 32333 32252 Titin
CAMK TTN TITIN_HUMAN 4JNWA Q8WZ42 32172 32491 34350.0 No_ligand No_ligand Pseudo DFGin 6.686 15.269 ABAminus -116.99, -2.14 -118.65, 122.2 -132.57, 18.41 290.09, 79.31 -63.31, -15.64 out-out out 10.849 Saltbr-out 4.793 HRD-in -91.99, -54.34 75.06, 8.93 out-in-out SNCoio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioo APE10-dihe-na -161.02, 157.09 APE9-dihe-na -117.92, -26.31 APE8-dihe-in -105.12, 102.28 APE8-rot-none 999.0 APE67-dihe-in -63.27, -22.9 -69.57, -21.96 APE12-dist-in 7.315 APE11-dist-in 8.022 APE10-dist-out 10.513 APE9-dist-out 10.349 None None None XRAY 2.06 0.167 0.204 A 324 320 0 0 0 0 [[32178, 32432]] 1.0 4jnw CAMK_TTN_HUMAN CAMK 1.3e-78 270.0 1 256 256 32317 32318 32319 32321 32323 32207 32222 32226 32295 32297 32296 32298 32356 32344 32339 32338 32337 32336 32335 32334 32333 32252 Titin
CAMK TTN TITIN_HUMAN 4JNWB Q8WZ42 32172 32492 34350.0 No_ligand No_ligand Pseudo DFGin 6.749 15.292 ABAminus -118.57, -0.9 -117.06, 125.69 -137.2, 17.6 292.87, 80.6 -64.03, -12.11 out-out out 10.959 Saltbr-out 4.948 HRD-in -90.25, -54.84 76.1, 3.64 out-in-out SNCoio in-out ActLoopNT-in 2.994 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iooo APE10-dihe-na -158.84, 158.1 APE9-dihe-na -121.51, -17.99 APE8-dihe-in -112.0, 93.64 APE8-rot-none 999.0 APE67-dihe-in -62.34, -21.33 -67.09, -23.25 APE12-dist-in 7.495 APE11-dist-out 7.983 APE10-dist-out 10.521 APE9-dist-out 10.351 None None None XRAY 2.06 0.167 0.204 B 324 321 0 0 0 0 [[32178, 32432]] 1.0 4jnw CAMK_TTN_HUMAN CAMK 1.3e-78 270.0 1 256 256 32317 32318 32319 32321 32323 32207 32222 32226 32295 32297 32296 32298 32356 32344 32339 32338 32337 32336 32335 32334 32333 32252 Titin
CAMK TTN TITIN_HUMAN 6YGNA Q8WZ42 32046 32594 34350.0 No_ligand No_ligand Pseudo DFGin 6.762 15.366 ABAminus -115.28, 1.72 -123.56, 124.55 -135.58, 21.33 288.63, 78.22 -67.2, -13.32 out-out out 11.067 Saltbr-out 4.825 HRD-in -88.18, -53.67 67.3, 21.18 out-in-out SNCoio in-out ActLoopNT-in 2.904 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioo APE10-dihe-na -156.84, 153.88 APE9-dihe-na -111.99, -16.7 APE8-dihe-in -110.46, 93.88 APE8-rot-none 999.0 APE67-dihe-in -62.26, -17.21 -67.36, -22.52 APE12-dist-in 7.69 APE11-dist-in 8.123 APE10-dist-out 10.452 APE9-dist-out 10.498 None None None XRAY 2.4 0.174 0.228 A 549 549 0 0 0 0 [[32178, 32432]] 1.0 6ygn CAMK_TTN_HUMAN CAMK 5.9e-78 268.0 1 256 256 32317 32318 32319 32321 32323 32207 32222 32226 32295 32297 32296 32298 32356 32344 32339 32338 32337 32336 32335 32334 32333 32252 Titin
CAMK TTN TITIN_HUMAN 6YGNB Q8WZ42 32046 32594 34350.0 No_ligand No_ligand Pseudo DFGin 6.761 15.592 ABAminus -114.91, 3.5 -126.35, 122.2 -136.48, 21.32 287.83, 78.52 -68.05, -14.36 out-out out 11.206 Saltbr-out 5.008 HRD-in -92.6, -53.51 65.74, 20.58 out-in-out SNCoio in-out ActLoopNT-in 2.985 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioo APE10-dihe-na -159.78, 153.24 APE9-dihe-na -112.8, -17.54 APE8-dihe-in -108.31, 93.6 APE8-rot-none 999.0 APE67-dihe-in -63.95, -17.11 -65.81, -22.01 APE12-dist-in 7.884 APE11-dist-in 8.101 APE10-dist-out 10.509 APE9-dist-out 10.525 None None None XRAY 2.4 0.174 0.228 B 549 549 0 0 0 0 [[32178, 32432]] 1.0 6ygn CAMK_TTN_HUMAN CAMK 5.9e-78 268.0 1 256 256 32317 32318 32319 32321 32323 32207 32222 32226 32295 32297 32296 32298 32356 32344 32339 32338 32337 32336 32335 32334 32333 32252 Titin
CK1 VRK3 VRK3_HUMAN 2JIIA Q8IV63 141 472 474.0 No_ligand No_ligand Pseudo DFGin 8.058 13.448 BLAminus -126.84, -158.76 59.27, 60.76 -88.16, 20.44 296.11, 92.21 -53.1, -27.84 in-in in 8.077 Saltbr-in 2.706 HRD-in -67.98, -48.21 89.48, -15.23 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -72.85, 117.18 APE9-dihe-na 111.48, -175.87 APE8-dihe-in -67.32, 115.98 APE8-rot-na 192.14 APE67-dihe-in -71.31, -23.63 -54.42, -32.09 APE12-dist-in 13.854 APE11-dist-in 12.424 APE10-dist-in 6.69 APE9-dist-in 4.861 None None None XRAY 2.0 0.181 0.223 A 352 321 11 0 0 0 [[166, 455]] 1.0 2jii CK1_VRK3_HUMAN CK1 4.8e-96 327.1 1 261 261 325 326 327 329 331 203 214 218 303 305 304 306 372 360 355 354 353 352 351 350 349 260 Serine/threonine-protein kinase VRK3
CK1 VRK3 VRK3_HUMAN 2JIIB Q8IV63 138 472 474.0 No_ligand No_ligand Pseudo DFGin 7.972 13.62 BLAminus -126.23, -160.08 62.29, 57.97 -88.31, 21.29 296.85, 92.8 -56.12, -25.41 in-in in 8.204 Saltbr-in 2.738 HRD-in -68.53, -45.66 90.53, -18.15 in-in-in SNCiii in-in ActLoopNT-in 2.872 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -73.7, 114.01 APE9-dihe-na 113.19, -176.53 APE8-dihe-in -66.63, 117.55 APE8-rot-na 191.52 APE67-dihe-in -72.55, -20.81 -57.04, -32.6 APE12-dist-in 13.86 APE11-dist-in 12.368 APE10-dist-in 6.624 APE9-dist-in 4.974 None None None XRAY 2.0 0.181 0.223 B 352 325 10 0 0 0 [[166, 455]] 1.0 2jii CK1_VRK3_HUMAN CK1 4.8e-96 327.1 1 261 261 325 326 327 329 331 203 214 218 303 305 304 306 372 360 355 354 353 352 351 350 349 260 Serine/threonine-protein kinase VRK3
OTHER MLKL MLKL_HUMAN 6O5ZA Q8NB16 191 470 471.0 No_ligand No_ligand Pseudo DFGin 5.443 14.318 BLAminus -137.01, -155.47 64.86, 62.95 -104.46, 17.08 308.51, 109.01 -69.75, 152.23 in-in in 8.314 Saltbr-in 2.576 HRD-na-E -62.32, -49.91 99.66, -25.44 in-out-out SNCioo out-out ActLoopNT-out 12.971 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -58.47, 131.06 APE9-dihe-na -68.43, 136.41 APE8-dihe-out -55.97, -34.58 APE8-rot-out 73.81 APE67-dihe-in -63.07, -19.3 -55.62, -29.72 APE12-dist-out 15.802 APE11-dist-out 20.901 APE10-dist-out 18.955 APE9-dist-out 13.509 None None None XRAY 2.285 0.188 0.232 A 287 271 9 0 0 9 [[204, 468]] 1.0 6o5z OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 7JXUA Q8NB16 191 471 471.0 No_ligand No_ligand Pseudo DFGin 10.233 17.137 BLAplus -132.65, -169.61 81.08, 16.1 -134.12, -7.44 71.35, 105.39 -101.21, 148.73 out-out out 16.392 Saltbr-out 12.623 HRD-na-E -66.65, -47.96 95.71, -27.61 out-out-out SNCooo out-out ActLoopNT-out 12.645 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -121.95, 127.81 APE9-dihe-na -65.07, 143.96 APE8-dihe-out -61.15, -31.11 APE8-rot-out 55.57 APE67-dihe-in -65.35, -21.19 -55.84, -32.25 APE12-dist-out 20.752 APE11-dist-out 23.974 APE10-dist-out 23.051 APE9-dist-out 13.357 None None None XRAY 2.44 0.204 0.24 A 287 281 0 0 0 0 [[204, 468]] 1.0 7jxu OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 7JXUB Q8NB16 191 471 471.0 No_ligand No_ligand Pseudo DFGin 10.316 17.087 BLAplus -140.29, -170.33 85.23, 13.17 -130.42, -22.22 65.36, 105.52 -88.31, 149.29 out-out out 16.023 Saltbr-out 12.194 HRD-na-E -66.79, -51.2 109.52, -44.96 out-out-out SNCooo out-out ActLoopNT-out 12.75 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -113.61, 128.79 APE9-dihe-na -66.68, 142.09 APE8-dihe-out -60.09, -31.37 APE8-rot-out 51.22 APE67-dihe-in -64.39, -17.94 -56.16, -31.14 APE12-dist-out 20.441 APE11-dist-out 23.536 APE10-dist-out 22.622 APE9-dist-out 13.679 None None None XRAY 2.44 0.204 0.24 B 287 281 0 0 0 0 [[204, 468]] 1.0 7jxu OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 7MONA Q8NB16 191 469 471.0 ZL1:501 Type1 Pseudo DFGin 9.979 16.865 BLAplus -145.54, -169.15 78.1, 22.67 -139.07, -9.53 71.34, 104.02 -105.01, 150.93 out-out out 16.381 Saltbr-out 13.326 HRD-na-E -68.26, -49.99 100.84, -31.32 out-out-out SNCooo out-out ActLoopNT-out 12.642 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -104.91, 135.41 APE9-dihe-na -71.07, 134.23 APE8-dihe-out -64.44, -25.38 APE8-rot-out 60.07 APE67-dihe-in -61.51, -31.54 -61.49, -26.48 APE12-dist-out 19.855 APE11-dist-out 24.032 APE10-dist-out 23.012 APE9-dist-out 13.36 None None None XRAY 2.23 0.212 0.26 A 287 268 11 0 0 8 [[204, 468]] 1.0 7mon OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 4MWIA Q8NB16 193 470 471.0 PXN:501 Allosteric Pseudo DFGin 5.101 14.027 BLBminus -145.19, 176.51 81.47, 24.62 -54.37, 137.54 316.54, 101.19 -155.24, 156.88 in-in in 8.284 Saltbr-in 2.785 HRD-na-E -64.85, -47.54 108.98, -24.83 in-out-out SNCioo out-out ActLoopNT-out 9.848 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -117.89, 131.59 APE9-dihe-na -66.57, 138.55 APE8-dihe-out -59.77, -32.75 APE8-rot-in 293.62 APE67-dihe-in -64.78, -27.84 -54.61, -33.19 APE12-dist-out 18.709 APE11-dist-out 22.428 APE10-dist-out 19.559 APE9-dist-out 13.893 None None None XRAY 1.7 0.166 0.194 A 294 266 12 0 0 12 [[204, 468]] 1.0 4mwi OTHER_MLKL_HUMAN TKL 1.3e-50 178.3 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 6BWKA Q8NB16 192 470 471.0 No_ligand No_ligand Pseudo DFGin 5.543 14.506 BLBminus -134.48, -157.9 71.65, 72.71 -113.01, 128.24 304.19, 2.01 -171.84, 999.0 in-none in 8.32 Saltbr-none 999.0 HRD-na-E -70.14, -73.85 121.54, -3.94 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -50.44, -32.47 APE9-dihe-na -66.22, -37.06 APE8-dihe-out -125.32, 42.89 APE8-rot-in 304.11 APE67-dihe-in -60.02, -24.26 -42.43, -39.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.03 T357E,S358E None None XRAY 2.79 0.257 0.297 A 287 263 16 0 0 16 [[204, 468]] 1.0 6bwk OTHER_MLKL_HUMAN TKL 7.6e-51 179.1 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 7JW7A Q8NB16 191 470 471.0 No_ligand No_ligand Pseudo DFGin 5.408 14.242 BLBminus -135.55, -168.18 79.35, 51.65 -93.92, 124.73 313.81, 102.38 -45.2, 999.0 in-in in 8.027 Saltbr-in 3.51 HRD-na-E -77.9, -36.2 97.95, -59.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, -51.94 APE9-dihe-na -65.12, 159.46 APE8-dihe-in -56.6, 134.48 APE8-rot-out 181.21 APE67-dihe-in -63.92, -31.38 -109.1, 12.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.171 None None None XRAY 2.63 0.23 0.281 A 287 256 24 0 0 19 [[204, 468]] 1.0 7jw7 OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 8SLZA Q8NB16 191 469 471.0 No_ligand No_ligand Pseudo DFGin 5.233 14.227 BLBminus -150.61, -167.39 68.99, 34.67 -68.29, 133.66 314.13, 95.49 -158.29, 157.94 in-in in 8.235 Saltbr-in 3.271 HRD-na-E -67.15, -50.86 111.36, -33.45 in-out-out SNCioo out-out ActLoopNT-out 10.041 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -117.52, 132.52 APE9-dihe-na -65.28, 139.38 APE8-dihe-out -65.39, -23.86 APE8-rot-out 181.55 APE67-dihe-in -69.04, -23.74 -66.59, -23.09 APE12-dist-out 21.373 APE11-dist-out 21.61 APE10-dist-out 19.417 APE9-dist-out 14.106 None TPO357,SEP358 TPO357,SEP358 XRAY 2.3 0.204 0.234 A 287 265 14 0 0 14 [[204, 468]] 1.0 8slz OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 4M67A Q8NB16 192 469 471.0 No_ligand No_ligand Pseudo DFGin 5.135 14.327 BLBminus -139.33, 178.33 78.86, 30.59 -63.54, 143.02 316.28, 95.46 -163.25, 152.36 in-in in 8.294 Saltbr-in 2.87 HRD-na-E -69.35, -45.81 105.49, -24.9 in-out-out SNCioo out-out ActLoopNT-out 9.945 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -114.78, 129.69 APE9-dihe-na -64.48, 137.26 APE8-dihe-out -54.3, -46.25 APE8-rot-out 173.11 APE67-dihe-in -60.1, -29.27 -51.47, -31.0 APE12-dist-out 20.382 APE11-dist-out 22.459 APE10-dist-out 19.663 APE9-dist-out 14.217 None None None XRAY 1.9 0.206 0.225 A 293 264 14 0 0 14 [[204, 468]] 1.0 4m67 OTHER_MLKL_HUMAN TKL 1.3e-50 178.3 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 6LK6A Q8NB16 192 470 471.0 No_ligand No_ligand Pseudo DFGin 5.213 14.238 BLBminus -140.9, -170.14 65.42, 43.61 -73.62, 139.5 313.43, 104.69 -170.25, 149.43 in-in in 8.334 Saltbr-in 2.996 HRD-na-E -65.81, -51.34 97.84, -20.78 in-out-out SNCioo out-out ActLoopNT-out 9.808 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -101.65, 139.93 APE9-dihe-na -76.17, 137.87 APE8-dihe-out -56.28, -33.41 APE8-rot-out 70.42 APE67-dihe-in -50.97, -36.19 -56.07, -45.36 APE12-dist-out 19.515 APE11-dist-out 22.474 APE10-dist-out 19.881 APE9-dist-out 13.826 T357A,S358A None None XRAY 2.41 0.211 0.247 A 293 265 14 0 0 14 [[204, 468]] 1.0 6lk6 OTHER_MLKL_HUMAN TKL 2.7e-50 177.3 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 6LK5A Q8NB16 192 470 471.0 No_ligand No_ligand Pseudo DFGin 5.11 14.286 BLBminus -141.79, -176.2 75.53, 28.55 -58.2, 124.61 313.01, 96.64 -149.56, 158.33 in-in in 8.237 Saltbr-in 3.182 HRD-na-E -64.32, -47.98 104.12, -32.13 in-out-out SNCioo out-out ActLoopNT-out 9.936 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -108.35, 134.78 APE9-dihe-na -64.51, 142.03 APE8-dihe-out -60.77, -31.01 APE8-rot-out 173.43 APE67-dihe-in -57.88, -30.62 -62.19, -38.79 APE12-dist-out 18.924 APE11-dist-out 22.425 APE10-dist-out 19.628 APE9-dist-out 13.871 T357E,S358D None None XRAY 2.5 0.196 0.238 A 471 265 14 0 0 14 [[204, 468]] 1.0 6lk5 OTHER_MLKL_HUMAN TKL 4e-50 177.2 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 5KO1A Q8NB16 192 470 471.0 6UY:501 Type1 Pseudo DFGin 4.808 14.578 BLBminus -140.42, -174.32 76.63, 35.3 -54.73, 138.73 314.86, 105.28 -152.71, 153.41 in-in in 8.458 Saltbr-in 2.748 HRD-na-E -68.56, -45.64 105.05, -24.44 in-out-out SNCioo out-out ActLoopNT-out 10.017 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -113.74, 135.2 APE9-dihe-na -68.0, 131.39 APE8-dihe-out -57.71, -40.85 APE8-rot-in 266.07 APE67-dihe-in -60.07, -28.3 -49.24, -31.82 APE12-dist-out 19.02 APE11-dist-out 22.517 APE10-dist-out 19.51 APE9-dist-out 14.173 E366A,K367A None None XRAY 2.16 0.19 0.226 A 283 265 14 0 0 14 [[204, 468]] 1.0 5ko1 OTHER_MLKL_HUMAN TKL 5.2e-50 176.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 6O5ZB Q8NB16 190 467 471.0 LN4:501 Type2 Pseudo DFGout 14.831 7.098 None -138.35, -166.14 -159.95, 69.78 -102.91, 999.0 194.77, 99.88 999.0, 999.0 in-out in 8.184 Saltbr-out 3.829 HRD-na-E -64.26, -51.93 98.68, -26.13 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -59.03, 132.55 APE9-dihe-na -64.81, 136.14 APE8-dihe-out -54.72, -38.12 APE8-rot-in 307.78 APE67-dihe-in -62.93, -23.04 -55.72, -31.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.392 None None None XRAY 2.285 0.188 0.232 B 287 260 19 0 0 12 [[204, 468]] 1.0 6o5z OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 5KNJA Q8NB16 193 468 471.0 6UX:501 Type1 Pseudo None 999.0 999.0 None -135.25, 171.18 -163.91, 150.5 -79.14, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.182 Saltbr-in 2.806 HRD-na-E -70.33, -43.91 105.29, -17.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -112.22, 131.74 APE9-dihe-na -62.16, 135.85 APE8-dihe-out -59.27, -43.82 APE8-rot-in 300.34 APE67-dihe-in -57.77, -31.82 -42.79, -35.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.573 E366A,K367A None None XRAY 2.88 0.196 0.256 A 283 252 24 0 0 18 [[204, 468]] 1.0 5knj OTHER_MLKL_HUMAN TKL 5.2e-50 176.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 5KNJB Q8NB16 192 469 471.0 6UX:501 Type1 Pseudo None 999.0 999.0 None -136.96, 165.94 -88.72, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.092 Saltbr-in 2.838 HRD-na-E -70.61, -44.28 104.64, -17.59 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -135.3, 131.22 APE9-dihe-na -64.5, 137.16 APE8-dihe-out -52.4, -47.35 APE8-rot-in 302.78 APE67-dihe-in -59.21, -30.37 -42.44, -36.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.867 E366A,K367A None None XRAY 2.88 0.196 0.256 B 283 259 19 0 0 19 [[204, 468]] 1.0 5knj OTHER_MLKL_HUMAN TKL 5.2e-50 176.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER PAN3 PAN3_HUMAN 9QTUA Q58A45 470 887 887.0 No_ligand No_ligand Pseudo DFGin 7.629 12.618 BLBminus -129.14, 168.31 55.8, 57.39 -86.82, 126.91 289.05, 999.0 84.49, -7.45 out-na out 16.938 Saltbr-na 999.0 HRD-in -70.23, -48.45 52.51, 26.26 na-out-na SNCaoa out-na ActLoopNT-out 6.726 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -59.17, 133.94 APE9-dihe-na -139.77, 155.63 APE8-dihe-na -106.23, 3.84 APE8-rot-na 207.6 APE67-dihe-na -83.45, 50.15 -63.24, -21.41 APE12-dist-na 5.615 APE11-dist-na 8.587 APE10-dist-na 9.043 APE9-dist-na 15.452 None None None EM 4.6 999.0 999.0 A 863 418 0 0 0 0 [[472, 759]] 1.0 9qtu OTHER_PAN3_HUMAN PAN3 3.5e-175 587.1 1 288 288 657 658 659 661 663 521 536 540 637 639 638 640 686 676 671 670 669 668 667 666 665 570 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_HUMAN 9QTUB Q58A45 470 887 887.0 No_ligand No_ligand Pseudo DFGin 8.263 12.02 BLBminus -100.76, 176.11 56.23, 61.14 -97.32, 152.4 308.88, 999.0 53.22, 50.35 out-na out 16.294 Saltbr-na 999.0 HRD-in -72.51, -40.23 43.56, 28.97 na-out-na SNCaoa out-na ActLoopNT-out 7.368 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -88.38, 114.43 APE9-dihe-na -132.3, 150.78 APE8-dihe-na -89.72, 17.82 APE8-rot-na 302.92 APE67-dihe-na -83.3, 51.22 -62.52, -39.08 APE12-dist-na 5.216 APE11-dist-na 8.336 APE10-dist-na 9.036 APE9-dist-na 16.012 None None None EM 4.6 999.0 999.0 B 863 418 0 0 0 0 [[472, 759]] 1.0 9qtu OTHER_PAN3_HUMAN PAN3 3.5e-175 587.1 1 288 288 657 658 659 661 663 521 536 540 637 639 638 640 686 676 671 670 669 668 667 666 665 570 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PEAK1 PEAK1_HUMAN 6BHCA Q9H792 1285 1743 1746.0 No_ligand No_ligand Pseudo DFGin 5.695 15.242 BLAminus -137.03, -177.55 61.13, 81.47 -100.07, 34.54 288.4, 76.8 -70.97, -28.29 out-na out 10.366 Saltbr-na 999.0 HRD-in -68.45, -48.56 69.76, 5.84 na-in-out SNCaio in-out ActLoopNT-in 2.957 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -102.07 APE8-dihe-out -85.98, -28.63 APE8-rot-na 192.98 APE67-dihe-in -67.0, -16.19 -77.03, -7.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.508 S1542T None None XRAY 2.3 0.196 0.234 A 438 370 43 0 0 9 [[1319, 1673]] 1.0 6bhc OTHER_PEAK1_HUMAN PEAK 6.7e-47 571.2 1 94 322 1554 1555 1556 1558 1560 1359 1374 1378 1513 1515 1514 1516 1591 1580 1575 1574 1573 1572 1571 1570 1569 1464 Inactive tyrosine-protein kinase PEAK1
OTHER PIK3R4 PI3R4_HUMAN 8SORA Q99570 15 1358 1358.0 ADP:1401 ATPlike Pseudo DFGin 9.418 15.81 BLBminus -148.68, -163.36 56.86, 40.25 -54.73, 139.1 286.63, 79.79 -95.49, 38.09 out-out out 17.808 Saltbr-out 21.09 HRD-in -78.26, -64.21 93.22, -18.74 out-out-out SNCooo out-out ActLoopNT-out 9.121 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na 53.41, 44.04 APE9-dihe-na -115.24, -10.88 APE8-dihe-out 68.3, 15.78 APE8-rot-na 299.15 APE67-dihe-out -125.94, 101.57 -74.9, 135.12 APE12-dist-out 14.302 APE11-dist-out 17.974 APE10-dist-out 21.055 APE9-dist-out 15.977 None None None EM 3.96 999.0 999.0 A 1358 1156 28 0 0 0 [[19, 321]] 1.0 8sor OTHER_PIK3R4_HUMAN PIK3R4 5.8e-151 507.9 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 9MHFA Q99570 14 1358 1358.0 No_ligand No_ligand Pseudo DFGin 9.316 15.926 BLBminus -137.15, 164.9 65.91, 49.84 -57.2, 122.9 277.63, 71.86 -84.62, 59.4 out-out out 18.109 Saltbr-out 17.236 HRD-out -96.05, 90.63 -67.78, 11.21 out-out-out SNCooo out-out ActLoopNT-out 9.113 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na 62.11, 44.99 APE9-dihe-na -103.33, -9.73 APE8-dihe-out 66.79, 8.06 APE8-rot-na 292.08 APE67-dihe-out -138.42, 103.87 -64.74, 143.63 APE12-dist-out 14.437 APE11-dist-out 18.408 APE10-dist-out 20.977 APE9-dist-out 15.949 None None None EM 2.73 999.0 999.0 A 1409 1179 27 0 0 0 [[19, 321]] 1.0 9mhf OTHER_PIK3R4_HUMAN PIK3R4 6.2e-151 507.8 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 9MHGA Q99570 2 1358 1358.0 No_ligand No_ligand Pseudo DFGin 9.585 16.209 BLBminus -138.69, 173.76 59.25, 52.03 -58.14, 130.77 283.01, 77.56 -95.81, 48.2 out-out out 18.272 Saltbr-out 21.234 HRD-in -80.12, -61.33 90.81, -7.5 out-out-out SNCooo out-out ActLoopNT-out 9.246 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na 54.37, 16.6 APE9-dihe-na -78.09, -5.34 APE8-dihe-out 69.83, -1.25 APE8-rot-na 218.72 APE67-dihe-out -116.55, 112.58 -66.54, 126.46 APE12-dist-out 14.093 APE11-dist-out 17.864 APE10-dist-out 20.978 APE9-dist-out 15.65 None None None EM 3.2 999.0 999.0 A 1409 1188 19 0 0 0 [[19, 321]] 1.0 9mhg OTHER_PIK3R4_HUMAN PIK3R4 6.2e-151 507.8 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 9C82A Q99570 64 1358 1358.0 No_ligand No_ligand Pseudo None 999.0 999.0 None -164.16, -177.07 55.57, 42.13 -52.45, 120.86 999.0, 999.0 -77.68, 59.73 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.24, -54.58 79.91, -42.88 none-out-out SNCnoo out-out ActLoopNT-out 8.339 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na 78.23, -5.89 APE9-dihe-na -85.52, -1.85 APE8-dihe-out 57.79, 25.3 APE8-rot-none 999.0 APE67-dihe-out -115.98, 93.47 -52.79, 127.92 APE12-dist-out 15.521 APE11-dist-out 19.431 APE10-dist-out 22.667 APE9-dist-out 16.035 None None None EM 6.84 999.0 999.0 A 1358 1038 84 0 0 0 [[19, 321]] 1.0 9c82 OTHER_PIK3R4_HUMAN PIK3R4 5.8e-151 507.9 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 7BL1CCC Q99570 12 1358 1358.0 No_ligand No_ligand Pseudo None 999.0 999.0 None -76.88, 121.2 -97.88, -157.84 -133.25, 23.54 999.0, 999.0 -119.58, 76.53 out-none out 19.336 Saltbr-none 999.0 HRD-out -62.71, 162.59 74.35, 11.28 none-out-out SNCnoo out-out ActLoopNT-out 17.743 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na -137.26, 20.08 APE9-dihe-na -166.34, -173.1 APE8-dihe-out -69.07, -7.2 APE8-rot-none 999.0 APE67-dihe-out -53.52, 153.93 -148.29, -158.16 APE12-dist-out 15.718 APE11-dist-out 15.611 APE10-dist-out 15.777 APE9-dist-out 18.72 None None None EM 9.8 0.157 999.0 CCC 1371 1189 0 0 0 0 [[19, 321]] 1.0 7bl1 OTHER_PIK3R4_HUMAN PIK3R4 5.9e-151 507.9 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 9MHHA Q99570 16 1358 1358.0 No_ligand No_ligand Pseudo None 999.0 999.0 None -128.48, 178.68 62.02, 54.05 -67.58, 106.95 999.0, 999.0 -108.31, 61.96 none-none none 999.0 Saltbr-none 999.0 HRD-in -78.85, -55.76 81.49, -5.71 none-out-out SNCnoo out-out ActLoopNT-out 9.548 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na 57.34, 14.48 APE9-dihe-na -81.14, -9.46 APE8-dihe-out 59.93, 19.07 APE8-rot-none 999.0 APE67-dihe-out -125.77, 107.65 -89.25, 132.69 APE12-dist-out 15.001 APE11-dist-out 17.495 APE10-dist-out 20.139 APE9-dist-out 15.78 None None None EM 4.5 999.0 999.0 A 1409 1191 19 0 0 0 [[19, 321]] 1.0 9mhh OTHER_PIK3R4_HUMAN PIK3R4 6.2e-151 507.8 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PRAG1 PRAG1_HUMAN 5VE6A Q86YV5 944 1405 1406.0 No_ligand No_ligand Pseudo None 999.0 15.913 None -72.21, 156.31 -91.78, 163.14 -113.76, 999.0 51.93, 89.28 999.0, 999.0 none-na none 999.0 Saltbr-na 999.0 HRD-out -76.41, 103.68 -60.03, -25.85 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.953 0.222 0.262 A 492 348 95 0 0 21 [[984, 1335]] 1.0 5ve6 OTHER_PRAG1_HUMAN PEAK 1.1e-148 503.5 1 349 349 1215 1216 1217 1219 1221 1024 1034 1038 1142 1144 1143 1145 1253 1242 1237 1236 1235 1234 1233 1232 1231 1093 Inactive tyrosine-protein kinase PRAG1
OTHER RNASEL RN5A_HUMAN 4OAUC Q05823 25 719 741.0 ADP:801 ATPlike Pseudo DFGin 6.529 12.379 BLAminus -152.72, -178.03 59.98, 103.61 -125.32, 12.02 305.12, 98.0 -75.28, 8.76 in-in in 6.993 Saltbr-in 2.623 HRD-in -74.91, -47.94 67.23, 8.17 in-in-na SNCiia in-na ActLoopNT-in 2.913 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -67.73, 111.98 APE9-dihe-na -66.2, -20.72 APE8-dihe-na -68.67, -28.85 APE8-rot-na 187.68 APE67-dihe-na -72.58, -38.81 -76.25, -36.54 APE12-dist-na 14.068 APE11-dist-na 16.875 APE10-dist-na 14.985 APE9-dist-na 14.333 H672N None None XRAY 2.6 0.213 0.251 C 699 692 0 0 0 0 [[353, 594]] 1.0 4oau OTHER_RNASEL_HUMAN RNASEL 4.1e-136 459.9 1 242 242 502 503 504 506 508 392 404 408 482 484 483 485 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
OTHER RNASEL RN5A_HUMAN 4OAVB Q05823 24 717 741.0 ACP:801 ATPlike Pseudo DFGin 6.475 12.367 BLAminus -139.92, -178.5 65.74, 91.26 -114.98, 14.68 309.18, 101.1 -77.21, 3.69 in-in in 6.905 Saltbr-in 2.74 HRD-in -87.38, -45.25 69.13, -2.14 in-in-na SNCiia in-na ActLoopNT-in 3.06 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.56, 102.63 APE9-dihe-na -56.52, -19.13 APE8-dihe-na -66.25, -31.04 APE8-rot-na 198.81 APE67-dihe-na -66.21, -44.37 -71.69, -39.0 APE12-dist-na 15.293 APE11-dist-na 17.012 APE10-dist-na 15.02 APE9-dist-na 14.396 H672N None None XRAY 2.1 0.2 0.229 B 699 673 8 0 0 0 [[353, 594]] 1.0 4oav OTHER_RNASEL_HUMAN RNASEL 4.1e-136 459.9 1 242 242 502 503 504 506 508 392 404 408 482 484 483 485 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
OTHER RNASEL RN5A_HUMAN 4OAVD Q05823 26 719 741.0 ACP:1001 ATPlike Pseudo DFGin 6.559 12.405 BLAminus -138.71, -178.08 64.72, 95.25 -118.8, 14.99 306.98, 96.56 -77.32, 4.45 in-in in 6.904 Saltbr-in 2.919 HRD-in -73.82, -49.38 73.22, -2.68 in-in-na SNCiia in-na ActLoopNT-in 2.915 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.59, 112.49 APE9-dihe-na -62.01, -29.18 APE8-dihe-na -62.89, -32.55 APE8-rot-na 188.49 APE67-dihe-na -70.07, -38.9 -67.42, -39.34 APE12-dist-na 14.651 APE11-dist-na 16.869 APE10-dist-na 14.635 APE9-dist-na 14.352 H672N None None XRAY 2.1 0.2 0.229 D 699 674 7 0 0 0 [[353, 594]] 1.0 4oav OTHER_RNASEL_HUMAN RNASEL 4.1e-136 459.9 1 242 242 502 503 504 506 508 392 404 408 482 484 483 485 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
OTHER ULK4 ULK4_HUMAN 6TSZU Q96C45 2 285 1275.0 AGS:60301 ATPlike Pseudo DFGin 6.37 18.271 ABAminus -125.81, 9.4 -156.01, 117.6 -115.95, 19.15 288.81, 81.65 -56.0, -43.19 out-na out 14.288 Saltbr-na 999.0 HRD-in -78.74, -35.33 74.51, -30.17 na-in-out SNCaio in-out ActLoopNT-in 2.748 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -74.27, 133.36 APE9-dihe-na -108.57, -165.46 APE8-dihe-in -71.23, 118.04 APE8-rot-in 324.52 APE67-dihe-in -65.15, -30.07 -62.89, -23.31 APE12-dist-in 8.579 APE11-dist-out 6.171 APE10-dist-out 9.182 APE9-dist-in 5.697 None None None XRAY 1.9 0.203 0.253 U 305 283 1 0 0 1 [[4, 280]] 1.0 6tsz OTHER_ULK4_HUMAN ULK 1.2e-118 401.1 1 256 256 138 139 140 142 144 34 46 50 118 120 119 121 201 189 184 183 182 181 180 179 178 76 Serine/threonine-protein kinase ULK4
OTHER ULK4 ULK4_HUMAN 6U5LA Q96C45 1 285 1275.0 3RJ:60301 Type1 Pseudo DFGin 6.226 18.455 ABAminus -136.12, 15.31 -157.37, 109.67 -112.82, 20.67 287.68, 79.1 -55.24, -38.19 out-na out 13.962 Saltbr-na 999.0 HRD-in -80.42, -35.75 72.37, -25.3 na-in-out SNCaio in-out ActLoopNT-in 2.715 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -90.65, 119.09 APE9-dihe-na -89.22, -142.79 APE8-dihe-in -86.05, 132.82 APE8-rot-out 161.95 APE67-dihe-in -66.84, -35.55 -76.04, -11.61 APE12-dist-in 8.948 APE11-dist-out 6.328 APE10-dist-out 9.158 APE9-dist-in 5.993 K172A,K173A None None XRAY 1.75 0.192 0.216 A 287 274 11 0 0 11 [[4, 280]] 1.0 6u5l OTHER_ULK4_HUMAN ULK 9.2e-119 401.4 1 256 256 138 139 140 142 144 34 46 50 118 120 119 121 201 189 184 183 182 181 180 179 178 76 Serine/threonine-protein kinase ULK4
RGC GUCY2C GUC2C_HUMAN 8FX4D P25092 550 755 1073.0 No_ligand No_ligand Pseudo None 999.0 999.0 None -103.03, -170.69 -90.03, -54.6 59.24, -64.74 158.72, 66.25 -58.61, -37.07 none-none none 999.0 Saltbr-none 999.0 HRD-in -94.68, -61.25 97.05, -18.95 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iioo APE10-dihe-na -89.56, 18.63 APE9-dihe-na -68.85, 85.4 APE8-dihe-in -65.22, 138.25 APE8-rot-na 189.13 APE67-dihe-out -65.39, -17.44 -155.76, 166.0 APE12-dist-in 12.911 APE11-dist-in 10.113 APE10-dist-out 15.685 APE9-dist-out 10.567 None None None EM 3.9 999.0 999.0 D 741 203 64 0 0 3 [[489, 747]] 1.0 8fx4 RGC_GUCY2C_HUMAN RGC 3.4e-106 361.1 2 265 264 631 632 633 635 637 516 532 536 611 613 612 614 662 650 645 644 643 642 641 640 639 562 Guanylyl cyclase C
RGC NPR1 ANPRA_HUMAN 9BCOA P16066 498 1053 1061.0 ATP:61101 ATPlike Pseudo DFGin 6.5 14.828 BLBplus -89.25, -164.06 42.72, 55.71 -135.24, 156.32 73.6, 95.91 78.22, -166.07 out-none out 16.928 Saltbr-none 999.0 HRD-out -74.2, 156.17 -59.96, -57.76 none-out-out SNCnoo out-out ActLoopNT-out 12.014 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -68.12, -1.53 APE9-dihe-na -60.93, -51.9 APE8-dihe-in -129.45, 85.23 APE8-rot-none 999.0 APE67-dihe-in -58.29, -38.75 -145.34, 13.28 APE12-dist-out 23.574 APE11-dist-out 20.43 APE10-dist-out 24.55 APE9-dist-out 15.858 None None None EM 4.4 999.0 999.0 A 1040 521 21 0 0 0 [[539, 803]] 1.0 9bco RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCOB P16066 501 1053 1061.0 ATP:61101 ATPlike Pseudo DFGin 6.035 14.05 BLBplus -88.95, 166.99 56.44, 21.66 -61.11, 145.38 64.96, 87.18 86.53, -116.67 out-none out 15.454 Saltbr-none 999.0 HRD-in -114.17, -53.78 98.92, -43.57 none-out-out SNCnoo out-out ActLoopNT-out 9.447 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -52.94, -51.71 APE9-dihe-na -111.55, -27.36 APE8-dihe-out -110.69, 11.24 APE8-rot-none 999.0 APE67-dihe-in -47.42, -35.74 -121.93, -1.95 APE12-dist-out 18.204 APE11-dist-out 21.211 APE10-dist-out 24.218 APE9-dist-out 14.706 None None None EM 4.4 999.0 999.0 B 1040 517 22 0 0 0 [[539, 803]] 1.0 9bco RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCPA P16066 505 842 1061.0 ATP:61101 ATPlike Pseudo DFGin 5.276 13.499 BLBplus -119.01, 147.56 55.81, 47.24 -98.35, -175.13 72.56, 101.5 63.71, -113.08 out-none out 15.017 Saltbr-none 999.0 HRD-in -101.28, -53.45 85.86, -1.89 none-out-out SNCnoo out-out ActLoopNT-out 10.061 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -56.32, -46.22 APE9-dihe-na -56.3, -35.86 APE8-dihe-out -106.06, -11.55 APE8-rot-na 74.77 APE67-dihe-in -55.12, -26.01 -77.38, -2.19 APE12-dist-out 20.65 APE11-dist-out 18.471 APE10-dist-out 23.005 APE9-dist-out 14.329 None None None EM 4.1 999.0 999.0 A 1040 314 21 0 0 0 [[539, 803]] 1.0 9bcp RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCPB P16066 503 841 1061.0 ATP:61101 ATPlike Pseudo DFGin 5.356 16.761 BLBtrans -138.66, -167.01 55.46, 41.07 -76.35, 89.03 193.7, 109.94 60.64, -128.0 out-none out 16.649 Saltbr-none 999.0 HRD-out -58.73, 127.47 -87.85, -41.33 none-out-out SNCnoo out-out ActLoopNT-out 12.183 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na -63.64, -13.04 APE9-dihe-na -73.26, -45.78 APE8-dihe-out -94.47, 23.47 APE8-rot-na 181.32 APE67-dihe-out -126.85, -50.61 -149.46, 92.68 APE12-dist-out 22.361 APE11-dist-out 19.678 APE10-dist-out 23.708 APE9-dist-out 15.401 None None None EM 4.1 999.0 999.0 B 1040 304 21 0 0 0 [[539, 803]] 1.0 9bcp RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCSA P16066 503 1055 1061.0 ATP:61100 ATPlike Pseudo DFGin 7.694 15.737 None -74.51, -65.19 38.98, 36.73 -149.34, 137.28 313.08, 80.76 -109.19, -24.55 out-none out 17.336 Saltbr-none 999.0 HRD-in -67.46, -13.34 80.4, -46.04 none-out-out SNCnoo out-out ActLoopNT-out 11.453 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -59.39, -44.12 APE9-dihe-na -70.77, -47.95 APE8-dihe-out -62.03, -25.18 APE8-rot-na 74.24 APE67-dihe-in -57.49, -15.22 -74.7, -41.95 APE12-dist-out 24.021 APE11-dist-out 19.76 APE10-dist-out 23.161 APE9-dist-out 13.347 None None None EM 4.4 999.0 999.0 A 1040 515 23 0 0 0 [[539, 803]] 1.0 9bcs RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCSB P16066 505 1055 1061.0 ATP:61100 ATPlike Pseudo None 999.0 999.0 None -84.33, 145.87 61.52, 18.75 -86.58, 62.78 999.0, 999.0 166.38, -163.08 out-none out 16.274 Saltbr-none 999.0 HRD-in -63.93, -40.93 80.49, -6.63 none-out-out SNCnoo out-out ActLoopNT-out 11.232 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -65.87, -23.07 APE9-dihe-na -84.75, -47.21 APE8-dihe-out -94.13, -13.59 APE8-rot-none 999.0 APE67-dihe-in -66.6, -21.85 -106.41, 28.83 APE12-dist-out 21.881 APE11-dist-out 20.406 APE10-dist-out 24.72 APE9-dist-out 14.261 None None None EM 4.4 999.0 999.0 B 1040 523 25 0 0 0 [[539, 803]] 1.0 9bcs RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
STE STRADA STRAA_HUMAN 2WTKB Q7RTN6 61 431 431.0 ANP:432 ATPlike Pseudo DFGin 5.116 13.443 BLAminus -117.01, -150.73 71.3, 24.64 -54.34, -28.38 297.58, 14.45 -57.14, -26.88 out-none out 10.016 Saltbr-none 999.0 HRD-in -75.87, -56.89 78.73, -4.32 none-in-out SNCnio in-out ActLoopNT-in 2.921 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -50.59, -53.43 APE9-dihe-na -67.53, -3.25 APE8-dihe-out -106.64, -20.66 APE8-rot-na 143.84 APE67-dihe-in -56.31, -21.98 -28.24, -53.75 APE12-dist-in 8.271 APE11-dist-out 7.456 APE10-dist-out 12.843 APE9-dist-out 9.371 None None None XRAY 2.65 0.24 0.291 B 373 311 52 0 0 0 [[69, 379]] 1.0 2wtk STE_STRADA_HUMAN STE 4e-87 298.0 1 257 257 212 213 214 216 218 100 118 122 192 194 193 195 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE STRADA STRAA_HUMAN 2WTKE Q7RTN6 60 431 431.0 ANP:432 ATPlike Pseudo DFGin 5.076 13.591 BLAminus -114.47, -147.76 66.21, 35.38 -66.23, -19.97 288.54, 169.08 -50.33, -33.69 in-none in 9.934 Saltbr-none 999.0 HRD-in -67.35, -61.05 78.73, -1.12 none-in-out SNCnio in-out ActLoopNT-in 2.861 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -48.76, -50.43 APE9-dihe-na -62.69, -41.12 APE8-dihe-out -68.21, -28.45 APE8-rot-na 167.78 APE67-dihe-in -49.8, -37.77 -23.43, -57.21 APE12-dist-in 8.119 APE11-dist-out 7.643 APE10-dist-out 12.951 APE9-dist-out 9.418 None None None XRAY 2.65 0.24 0.291 E 373 308 52 0 0 0 [[69, 379]] 1.0 2wtk STE_STRADA_HUMAN STE 4e-87 298.0 1 257 257 212 213 214 216 218 100 118 122 192 194 193 195 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE STRADA STRAA_HUMAN 3GNIB Q7RTN6 60 431 431.0 ATP:60001 ATPlike Pseudo DFGin 5.228 13.358 BLAminus -109.39, -155.43 74.77, 29.57 -67.06, -15.75 299.34, 10.06 -54.98, -34.79 in-none in 9.9 Saltbr-none 999.0 HRD-in -71.88, -63.47 83.33, 4.11 none-in-out SNCnio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -73.5, 108.36 APE9-dihe-na 128.9, -33.16 APE8-dihe-out -82.37, -8.26 APE8-rot-na 193.56 APE67-dihe-in -56.7, -25.37 -48.29, -50.45 APE12-dist-in 8.527 APE11-dist-out 7.098 APE10-dist-out 12.899 APE9-dist-out 9.897 None None None XRAY 2.35 0.207 0.254 B 389 290 56 0 0 0 [[69, 379]] 1.0 3gni STE_STRADA_HUMAN STE 4.7e-87 297.8 1 257 257 212 213 214 216 218 100 118 122 192 194 193 195 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE STRADA STRAA_HUMAN 8VSUB Q7RTN6 60 401 431.0 ADP:2001 ATPlike Pseudo DFGin 5.328 13.743 None -141.72, 9.36 -84.56, 30.72 -65.1, -14.12 305.81, 3.72 -62.58, -31.2 out-none out 10.229 Saltbr-none 999.0 HRD-out -66.66, 151.23 -136.62, 153.73 none-in-out SNCnio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -55.51, -37.77 APE9-dihe-na -75.16, -6.37 APE8-dihe-out -108.58, -14.7 APE8-rot-na 180.94 APE67-dihe-in -58.61, -34.89 -50.23, -38.37 APE12-dist-in 8.342 APE11-dist-out 7.821 APE10-dist-out 13.057 APE9-dist-out 11.052 None None None EM 2.86 999.0 999.0 B 429 306 36 0 0 0 [[69, 379]] 1.0 8vsu STE_STRADA_HUMAN STE 6.5e-87 297.3 1 257 257 212 213 214 216 218 100 118 122 192 194 193 195 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
TKL ILK ILK_HUMAN 9D5IA Q13418 182 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.261 6.842 None -85.91, 104.5 -70.94, -26.25 -67.8, 1.23 999.0, 999.0 -109.51, 3.6 out-out out 13.611 Saltbr-out 13.777 HRD-out 63.45, 28.98 -91.0, 110.88 out-out-out SNCooo out-out ActLoopNT-out 6.365 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -132.95, 115.89 APE9-dihe-na -99.41, -2.16 APE8-dihe-in -138.47, 54.8 APE8-rot-none 999.0 APE67-dihe-in -62.49, -23.03 -64.85, -19.12 APE12-dist-out 14.705 APE11-dist-in 13.99 APE10-dist-out 13.138 APE9-dist-out 13.265 R225A,C346S,C422S None None XRAY 1.5 0.23 0.267 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5i TKL_ILK_HUMAN TKL 2.8e-62 216.7 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3KMWA Q13418 185 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.3 6.975 None -80.97, 99.65 -67.11, -24.75 -72.37, 0.55 999.0, 999.0 -103.25, 4.58 out-out out 13.496 Saltbr-out 14.041 HRD-out 59.64, 26.4 -91.04, 116.86 out-out-out SNCooo out-out ActLoopNT-out 6.367 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -122.08, 118.72 APE9-dihe-na -100.74, -5.98 APE8-dihe-in -137.53, 58.2 APE8-rot-none 999.0 APE67-dihe-in -63.57, -23.06 -67.47, -16.05 APE12-dist-out 14.71 APE11-dist-out 14.04 APE10-dist-out 13.057 APE9-dist-out 13.027 C346S,C422S None None XRAY 2.0 0.199 0.203 A 271 268 0 0 0 0 [[192, 448]] 1.0 3kmw TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3REPA Q13418 185 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.264 6.894 None -81.35, 101.61 -70.12, -25.38 -69.18, -5.31 999.0, 999.0 -98.03, -0.84 out-out out 13.359 Saltbr-out 14.12 HRD-out 62.24, 23.62 -86.21, 112.03 out-out-out SNCooo out-out ActLoopNT-out 6.454 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -114.84, 122.73 APE9-dihe-na -97.69, -5.36 APE8-dihe-in -136.02, 58.25 APE8-rot-none 999.0 APE67-dihe-in -57.73, -27.19 -63.83, -23.69 APE12-dist-out 14.498 APE11-dist-in 13.981 APE10-dist-out 12.94 APE9-dist-out 13.101 C346S,C422S None None XRAY 1.8 0.206 0.238 A 271 268 0 0 0 0 [[192, 448]] 1.0 3rep TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3KMUA Q13418 185 451 452.0 No_ligand No_ligand Pseudo DFGinter 8.115 7.023 None -89.09, 107.07 -68.14, -22.77 -71.11, -14.21 999.0, 999.0 -91.44, 11.74 out-out out 13.695 Saltbr-out 11.012 HRD-out 62.49, 27.89 -91.99, 115.71 out-out-out SNCooo out-out ActLoopNT-out 6.597 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -104.26, 122.36 APE9-dihe-na -103.82, -5.41 APE8-dihe-in -135.57, 56.37 APE8-rot-none 999.0 APE67-dihe-in -59.41, -24.29 -65.19, -22.44 APE12-dist-out 15.046 APE11-dist-out 14.132 APE10-dist-out 12.999 APE9-dist-out 12.97 C346S,C422S None MSE272,MSE301,MSE305,MSE326,MSE331,MSE337,MSE350,MSE375,MSE398,MSE402,MSE425,MSE429,MSE441,MSE449 XRAY 1.8 0.202 0.236 A 271 267 0 0 0 0 [[192, 448]] 1.0 3kmu TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 6MIBA Q13418 183 452 452.0 No_ligand No_ligand Pseudo DFGinter 8.103 6.953 None -87.41, 112.59 -75.98, -22.17 -67.79, -12.67 999.0, 999.0 -94.49, 5.69 out-out out 14.011 Saltbr-out 12.861 HRD-out 64.37, 30.77 -90.77, 118.17 out-out-out SNCooo out-out ActLoopNT-out 6.381 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -106.73, 116.01 APE9-dihe-na -99.88, -3.31 APE8-dihe-in -137.02, 59.23 APE8-rot-none 999.0 APE67-dihe-in -59.55, -22.39 -68.5, -19.71 APE12-dist-out 15.073 APE11-dist-out 14.122 APE10-dist-out 13.25 APE9-dist-out 12.849 L207W None None XRAY 1.8 0.163 0.208 A 271 270 0 0 0 0 [[192, 448]] 1.0 6mib TKL_ILK_HUMAN TKL 6.7e-62 215.4 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5HA Q13418 182 452 452.0 IRE:701 Type1 Pseudo DFGinter 8.164 7.455 None -85.0, 107.56 -70.5, -21.19 -67.61, -12.48 999.0, 999.0 -96.85, 13.46 out-out out 14.137 Saltbr-out 13.105 HRD-out 65.35, 60.25 -109.45, 119.86 out-out-out SNCooo out-out ActLoopNT-out 5.911 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -110.76, 118.05 APE9-dihe-na -102.65, -7.28 APE8-dihe-in -135.36, 55.79 APE8-rot-none 999.0 APE67-dihe-in -64.5, -21.08 -63.95, -18.26 APE12-dist-out 14.988 APE11-dist-out 14.039 APE10-dist-out 13.236 APE9-dist-out 12.723 C346S,R371Q,C422S None None XRAY 1.5 0.197 0.224 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5h TKL_ILK_HUMAN TKL 1.2e-62 217.9 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5FA Q13418 182 452 452.0 DB8:501 Type1 Pseudo DFGinter 8.366 7.592 None -82.6, 123.95 -74.1, -11.79 -66.74, -13.57 999.0, 999.0 -72.54, 5.75 out-out out 14.123 Saltbr-out 15.4 HRD-out -123.23, 159.13 -69.32, -46.01 out-out-out SNCooo out-out ActLoopNT-out 5.554 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -109.48, 117.62 APE9-dihe-na -102.03, -10.5 APE8-dihe-in -134.11, 56.74 APE8-rot-none 999.0 APE67-dihe-in -63.21, -21.45 -62.91, -18.33 APE12-dist-out 15.638 APE11-dist-out 14.874 APE10-dist-out 14.406 APE9-dist-out 8.782 C346S,C422S None None XRAY 1.5 0.191 0.208 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5f TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5GAAAA Q13418 182 452 452.0 A1A2V:501 Type1 Pseudo DFGinter 8.166 7.277 None -88.06, 117.11 -74.33, -18.91 -68.4, -19.72 999.0, 999.0 -87.44, 16.53 out-out out 13.771 Saltbr-out 14.663 HRD-out 59.25, 38.65 -103.86, 109.49 out-out-out SNCooo out-out ActLoopNT-out 6.383 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -94.88, 120.39 APE9-dihe-na -102.76, -4.36 APE8-dihe-in -137.63, 56.3 APE8-rot-none 999.0 APE67-dihe-in -62.91, -23.12 -64.06, -19.38 APE12-dist-out 14.786 APE11-dist-in 13.895 APE10-dist-out 13.122 APE9-dist-out 13.0 C346S,C422S None None XRAY 1.55 0.195 0.221 AAAA 271 271 0 0 0 0 [[192, 448]] 1.0 9d5g TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5PA Q13418 182 452 452.0 AQ4:701 Type1 Pseudo DFGinter 8.061 7.428 None -85.71, 111.19 -68.8, -21.89 -73.77, -9.11 999.0, 999.0 -96.7, 8.17 out-out out 13.852 Saltbr-out 12.926 HRD-out 65.12, 30.52 -101.22, 117.74 out-out-out SNCooo out-out ActLoopNT-out 6.577 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -117.02, 119.23 APE9-dihe-na -104.23, -7.77 APE8-dihe-in -133.36, 56.94 APE8-rot-none 999.0 APE67-dihe-in -63.3, -21.52 -64.96, -18.17 APE12-dist-out 15.043 APE11-dist-in 13.976 APE10-dist-out 12.889 APE9-dist-out 12.754 C346S,C422S None None XRAY 1.5 0.188 0.21 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5p TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5EA Q13418 182 452 452.0 IRE:701,IRE:702 Type1,Type1 Pseudo DFGinter 8.017 7.524 None -89.37, 112.35 -72.14, -19.5 -70.86, -12.91 999.0, 999.0 -92.65, 14.01 out-out out 14.057 Saltbr-out 13.142 HRD-out -82.68, 123.44 -98.83, 148.34 out-out-out SNCooo out-out ActLoopNT-out 6.639 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -111.62, 119.46 APE9-dihe-na -104.32, -7.67 APE8-dihe-in -135.99, 56.58 APE8-rot-none 999.0 APE67-dihe-in -63.74, -21.2 -65.26, -17.82 APE12-dist-out 14.857 APE11-dist-in 13.808 APE10-dist-out 12.922 APE9-dist-out 11.885 C346S,C422S None None XRAY 1.5 0.188 0.21 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5e TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL IRAK3 IRAK3_HUMAN 6ZIWI Q9Y616 153 451 596.0 AGS:501 ATPlike Pseudo DFGin 7.058 15.43 BLAminus -137.94, 171.27 73.33, 92.98 -113.57, 22.08 299.33, 103.06 -63.05, -21.88 in-out in 8.777 Saltbr-out 6.076 HRD-in -68.03, -51.72 91.9, -24.04 out-in-none SNCoin in-none ActLoopNT-in 2.637 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.65, -29.02 999.0, 37.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.18 0.218 0.25 I 316 267 32 0 0 19 [[164, 445]] 1.0 6ziw TKL_IRAK3_HUMAN TKL 2.1e-70 243.3 4 266 263 310 311 312 314 316 192 212 216 290 292 291 293 356 344 339 338 337 336 335 334 333 242 Interleukin-1 receptor-associated kinase 3
TKL IRAK3 IRAK3_HUMAN 6RUUA Q9Y616 153 450 596.0 No_ligand No_ligand Pseudo DFGin 7.326 14.884 BLAminus -133.01, -174.08 57.44, 64.43 -91.56, 23.98 296.73, 105.83 -64.82, -31.62 in-out in 8.014 Saltbr-out 3.618 HRD-in -76.83, -46.42 68.87, -4.54 out-in-none SNCoin in-none ActLoopNT-in 3.015 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 24.62 APE8-rot-none 999.0 APE67-dihe-in -68.1, -25.53 -116.47, 47.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.95 0.23 0.26 A 315 285 13 0 0 10 [[164, 445]] 1.0 6ruu TKL_IRAK3_HUMAN TKL 2.1e-70 243.3 4 266 263 310 311 312 314 316 192 212 216 290 292 291 293 356 344 339 338 337 336 335 334 333 242 Interleukin-1 receptor-associated kinase 3
TKL IRAK3 IRAK3_HUMAN 6RUUB Q9Y616 152 452 596.0 No_ligand No_ligand Pseudo DFGin 7.022 14.986 BLAminus -150.92, 173.68 59.31, 65.47 -89.75, 25.43 295.48, 100.27 -67.54, -42.42 in-out in 7.949 Saltbr-out 4.374 HRD-in -61.73, -45.76 79.92, -72.1 out-in-out SNCoio in-out ActLoopNT-in 2.533 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -66.83, -49.08 APE9-dihe-na -65.03, -26.24 APE8-dihe-out -87.01, 8.46 APE8-rot-na 188.59 APE67-dihe-in -70.55, -3.31 -54.29, -46.92 APE12-dist-in 9.039 APE11-dist-out 6.734 APE10-dist-out 12.331 APE9-dist-out 10.531 None None None XRAY 2.95 0.23 0.26 B 315 286 15 0 0 8 [[164, 445]] 1.0 6ruu TKL_IRAK3_HUMAN TKL 2.1e-70 243.3 4 266 263 310 311 312 314 316 192 212 216 290 292 291 293 356 344 339 338 337 336 335 334 333 242 Interleukin-1 receptor-associated kinase 3
TKL IRAK3 IRAK3_HUMAN 6RUUC Q9Y616 179 454 596.0 No_ligand No_ligand Pseudo None 999.0 999.0 None -144.24, -178.09 -113.97, -57.44 -128.5, 145.24 999.0, 999.0 -123.81, 150.85 out-none out 14.971 Saltbr-none 999.0 HRD-out -119.66, 97.59 -63.5, -32.53 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -98.5 APE8-dihe-out -108.73, 12.85 APE8-rot-none 999.0 APE67-dihe-in -79.09, -35.3 -69.09, 2.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.296 None None None XRAY 2.95 0.23 0.26 C 315 245 50 0 0 21 [[164, 445]] 1.0 6ruu TKL_IRAK3_HUMAN TKL 2.1e-70 243.3 4 266 263 310 311 312 314 316 192 212 216 290 292 291 293 356 344 339 338 337 336 335 334 333 242 Interleukin-1 receptor-associated kinase 3
TKL KSR1 KSR1_HUMAN 9AXHC Q8IVT5 614 881 923.0 ANP:60901 ATPlike Pseudo DFGin 5.23 13.239 BLBplus -124.42, 164.81 64.66, 43.46 -90.48, 143.73 53.91, 91.43 61.22, 55.23 out-none out 14.31 Saltbr-none 999.0 HRD-in -67.1, -51.8 77.02, -11.89 none-out-out SNCnoo out-out ActLoopNT-out 7.657 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -64.2, -39.05 APE9-dihe-na -59.17, -48.89 APE8-dihe-out -66.09, -38.64 APE8-rot-na 184.07 APE67-dihe-in -61.76, -22.42 -60.74, -36.73 APE12-dist-out 16.89 APE11-dist-out 15.959 APE10-dist-out 20.499 APE9-dist-out 12.219 None None None XRAY 2.81 0.206 0.253 C 283 259 10 0 0 7 [[613, 879]] 1.0 9axh TKL_KSR1_HUMAN TKL 2.1e-68 236.7 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 9AXHD Q8IVT5 613 881 923.0 ANP:60901 ATPlike Pseudo DFGin 5.246 13.229 BLBplus -126.56, 169.35 63.03, 47.69 -96.52, 141.09 54.28, 88.59 76.52, 29.36 out-none out 14.488 Saltbr-none 999.0 HRD-in -67.9, -47.78 73.32, -2.62 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -60.7, -40.23 APE9-dihe-na -60.83, -42.14 APE8-dihe-out -70.49, -38.33 APE8-rot-na 183.99 APE67-dihe-in -64.38, -16.08 -60.51, -36.42 APE12-dist-out 17.087 APE11-dist-out 16.228 APE10-dist-out 20.701 APE9-dist-out 12.597 None None None XRAY 2.81 0.206 0.253 D 283 249 20 0 0 13 [[613, 879]] 1.0 9axh TKL_KSR1_HUMAN TKL 2.1e-68 236.7 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUWB Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.479 13.436 BLBplus -116.78, 175.7 58.02, 37.9 -91.13, 161.87 61.57, 85.28 62.4, -8.11 out-none out 13.34 Saltbr-none 999.0 HRD-in -64.36, -50.52 68.6, 3.9 none-out-out SNCnoo out-out ActLoopNT-out 7.126 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -75.12, -46.44 APE9-dihe-na -49.25, -41.63 APE8-dihe-out -65.16, -50.29 APE8-rot-na 182.96 APE67-dihe-in -55.58, -30.38 -61.8, -31.6 APE12-dist-out 17.682 APE11-dist-out 16.599 APE10-dist-out 21.026 APE9-dist-out 12.834 None None None XRAY 2.88 0.245 0.286 B 334 277 4 0 0 4 [[613, 879]] 1.0 7juw TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUXA Q8IVT5 600 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.302 12.887 BLBplus -130.76, 153.55 60.79, 41.41 -77.85, 152.64 59.13, 80.46 58.16, 12.6 out-none out 13.586 Saltbr-none 999.0 HRD-out -82.48, 84.18 -62.97, 148.26 none-out-out SNCnoo out-out ActLoopNT-out 7.062 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -85.2, -42.07 APE9-dihe-na -55.8, -29.41 APE8-dihe-out -77.82, -37.67 APE8-rot-na 188.53 APE67-dihe-in -61.89, -19.45 -62.94, -36.24 APE12-dist-out 17.427 APE11-dist-out 16.235 APE10-dist-out 20.624 APE9-dist-out 14.057 None None None XRAY 3.34 0.265 0.283 A 334 278 4 0 0 4 [[613, 879]] 1.0 7jux TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUYB Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.613 13.191 BLBplus -117.18, 175.18 57.71, 38.02 -91.22, 161.18 61.47, 85.63 62.09, -7.96 out-none out 13.395 Saltbr-none 999.0 HRD-in -64.77, -50.93 68.2, 3.89 none-out-out SNCnoo out-out ActLoopNT-out 7.067 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -74.87, -46.12 APE9-dihe-na -49.26, -41.38 APE8-dihe-out -64.88, -49.41 APE8-rot-na 183.95 APE67-dihe-in -56.03, -30.73 -61.35, -31.75 APE12-dist-out 17.556 APE11-dist-out 16.525 APE10-dist-out 20.947 APE9-dist-out 12.77 None None None XRAY 3.096 0.248 0.257 B 334 276 5 0 0 5 [[613, 879]] 1.0 7juy TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUZA Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.251 13.144 BLBplus -120.58, 157.85 65.97, 36.71 -81.68, 149.84 60.82, 87.44 61.36, 0.32 out-none out 13.842 Saltbr-none 999.0 HRD-in -63.05, -49.06 69.65, 1.96 none-out-out SNCnoo out-out ActLoopNT-out 6.963 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -71.77, -43.35 APE9-dihe-na -54.66, -39.8 APE8-dihe-out -69.49, -39.39 APE8-rot-na 184.11 APE67-dihe-in -64.95, -32.88 -59.75, -32.59 APE12-dist-out 17.573 APE11-dist-out 16.418 APE10-dist-out 20.831 APE9-dist-out 12.592 None None None XRAY 3.21 0.255 0.272 A 334 273 8 0 0 8 [[613, 879]] 1.0 7juz TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JV0A Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.544 13.231 BLBplus -113.37, 179.62 53.84, 36.37 -87.67, 157.34 63.1, 86.33 73.66, -16.65 out-none out 13.335 Saltbr-none 999.0 HRD-in -63.7, -53.29 73.57, 2.92 none-out-out SNCnoo out-out ActLoopNT-out 7.005 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -74.36, -44.01 APE9-dihe-na -53.64, -41.33 APE8-dihe-out -66.6, -51.73 APE8-rot-na 184.61 APE67-dihe-in -59.37, -29.99 -47.75, -40.44 APE12-dist-out 17.632 APE11-dist-out 16.659 APE10-dist-out 21.083 APE9-dist-out 12.781 None None None XRAY 3.63 0.247 0.26 A 334 276 5 0 0 5 [[613, 879]] 1.0 7jv0 TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JV1D Q8IVT5 600 881 923.0 ANP:901 ATPlike Pseudo DFGin 4.998 13.028 BLBplus -130.92, 154.93 60.0, 40.35 -76.18, 155.67 58.85, 79.94 54.95, 12.06 out-none out 13.786 Saltbr-none 999.0 HRD-out -81.07, 84.18 -62.62, 147.5 none-out-out SNCnoo out-out ActLoopNT-out 6.808 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -83.95, -45.7 APE9-dihe-na -55.75, -29.37 APE8-dihe-out -76.69, -37.65 APE8-rot-na 188.09 APE67-dihe-in -60.65, -19.03 -62.72, -36.82 APE12-dist-out 17.487 APE11-dist-out 16.348 APE10-dist-out 20.808 APE9-dist-out 14.145 None None None XRAY 3.62 0.278 0.303 D 334 275 7 0 0 7 [[613, 879]] 1.0 7jv1 TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR2 KSR2_HUMAN 2Y4IB Q6VAB6 653 931 950.0 ATP:1932 ATPlike Pseudo DFGin 6.039 13.357 BLBplus -163.04, 167.92 56.95, 32.67 -75.07, 155.41 46.1, 92.34 53.05, 51.5 out-none out 15.58 Saltbr-none 999.0 HRD-in -80.25, -38.53 67.56, -67.09 none-out-out SNCnoo out-out ActLoopNT-out 10.43 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -56.45, -137.53 APE9-dihe-na -67.8, 7.84 APE8-dihe-out -54.46, -37.41 APE8-rot-na 170.99 APE67-dihe-in -92.05, 13.42 -60.84, -28.22 APE12-dist-out 17.417 APE11-dist-out 14.576 APE10-dist-out 17.158 APE9-dist-out 12.262 None None None XRAY 3.46 0.233 0.293 B 319 265 14 0 0 10 [[665, 930]] 1.0 2y4i TKL_KSR2_HUMAN TKL 1.1e-70 244.1 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUQB Q6VAB6 652 932 950.0 ADP:1001 ATPlike Pseudo DFGin 5.723 13.43 BLBplus -139.35, 152.22 61.66, 33.54 -71.04, 141.2 52.07, 82.92 82.4, -21.94 out-none out 15.389 Saltbr-none 999.0 HRD-in -71.47, -51.16 73.41, 1.02 none-out-out SNCnoo out-out ActLoopNT-out 7.459 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -57.45, -45.23 APE9-dihe-na -90.48, -7.37 APE8-dihe-out -66.85, -54.6 APE8-rot-na 183.3 APE67-dihe-in -71.76, -8.04 -52.06, -44.72 APE12-dist-out 18.487 APE11-dist-out 15.103 APE10-dist-out 19.519 APE9-dist-out 11.963 None None None XRAY 3.22 0.256 0.288 B 342 277 4 0 0 3 [[665, 930]] 1.0 7juq TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JURB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.534 13.444 BLBplus -136.74, 172.29 64.43, 21.01 -64.29, 145.08 51.43, 88.21 72.32, -17.93 out-none out 13.058 Saltbr-none 999.0 HRD-in -74.46, -55.37 71.55, 3.38 none-out-out SNCnoo out-out ActLoopNT-out 7.607 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -61.97, 131.45 APE9-dihe-na 84.3, -3.37 APE8-dihe-out -70.0, -57.71 APE8-rot-na 184.79 APE67-dihe-in -71.0, 1.52 -53.02, -42.72 APE12-dist-out 18.483 APE11-dist-out 15.136 APE10-dist-out 19.742 APE9-dist-out 12.323 None None None XRAY 2.82 0.237 0.277 B 342 277 4 0 0 3 [[665, 930]] 1.0 7jur TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUSB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.883 13.383 BLBplus -127.91, 171.08 62.77, 22.74 -63.47, 150.27 47.2, 86.11 68.89, -21.25 out-none out 13.513 Saltbr-none 999.0 HRD-in -73.66, -56.88 73.44, -2.22 none-out-out SNCnoo out-out ActLoopNT-out 7.508 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -57.38, 137.79 APE9-dihe-na 90.37, -24.33 APE8-dihe-out -66.74, -57.02 APE8-rot-na 187.61 APE67-dihe-in -75.11, -1.38 -58.95, -34.29 APE12-dist-out 18.421 APE11-dist-out 15.077 APE10-dist-out 19.629 APE9-dist-out 12.036 None None None XRAY 2.99 0.249 0.265 B 342 276 5 0 0 4 [[665, 930]] 1.0 7jus TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUTB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.556 12.961 BLBplus -137.17, 153.82 70.92, 32.74 -74.86, 135.77 48.5, 88.18 74.13, -4.82 out-none out 14.209 Saltbr-none 999.0 HRD-in -85.35, -39.03 46.26, 13.05 none-out-out SNCnoo out-out ActLoopNT-out 7.196 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -53.57, -55.36 APE9-dihe-na -91.09, 3.18 APE8-dihe-out -71.8, -46.41 APE8-rot-na 181.21 APE67-dihe-in -68.18, -7.53 -62.86, -41.09 APE12-dist-out 18.127 APE11-dist-out 15.431 APE10-dist-out 19.558 APE9-dist-out 11.925 None None None XRAY 3.09 0.259 0.3 B 342 277 4 0 0 3 [[665, 930]] 1.0 7jut TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUUB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.773 13.221 BLBplus -133.64, 151.36 70.73, 33.64 -75.25, 133.98 46.29, 83.15 80.08, -8.46 out-none out 14.433 Saltbr-none 999.0 HRD-in -73.56, -47.69 67.59, 2.06 none-out-out SNCnoo out-out ActLoopNT-out 7.385 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -58.47, -51.54 APE9-dihe-na -86.76, 0.87 APE8-dihe-out -74.62, -44.43 APE8-rot-na 183.38 APE67-dihe-in -73.96, -6.37 -64.52, -36.97 APE12-dist-out 18.347 APE11-dist-out 15.59 APE10-dist-out 19.794 APE9-dist-out 12.093 None None None XRAY 3.19 0.242 0.258 B 342 277 4 0 0 3 [[665, 930]] 1.0 7juu TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUVB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.981 13.017 BLBplus -127.69, 170.94 63.29, 22.28 -64.16, 148.8 47.81, 86.58 68.48, -22.21 out-none out 13.605 Saltbr-none 999.0 HRD-in -73.05, -56.86 73.65, -2.34 none-out-out SNCnoo out-out ActLoopNT-out 7.503 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -57.84, 138.27 APE9-dihe-na 90.88, -24.23 APE8-dihe-out -67.14, -55.82 APE8-rot-na 188.73 APE67-dihe-in -75.46, -2.03 -58.92, -34.4 APE12-dist-out 18.296 APE11-dist-out 15.175 APE10-dist-out 19.835 APE9-dist-out 12.199 None None None XRAY 3.36 0.242 0.255 B 342 277 4 0 0 3 [[665, 930]] 1.0 7juv TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7UMBB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.511 13.333 BLBplus -122.69, -178.17 55.62, 31.28 -75.96, 141.02 47.41, 88.89 74.01, -10.38 out-none out 13.077 Saltbr-none 999.0 HRD-in -83.2, -50.32 69.21, 5.46 none-out-out SNCnoo out-out ActLoopNT-out 7.53 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -52.68, 124.31 APE9-dihe-na 106.73, -20.32 APE8-dihe-out -71.55, -49.08 APE8-rot-na 185.38 APE67-dihe-in -79.33, 2.43 -65.58, -32.18 APE12-dist-out 18.119 APE11-dist-out 15.398 APE10-dist-out 19.723 APE9-dist-out 12.009 None None None XRAY 3.231 0.231 0.268 B 342 277 4 0 0 3 [[665, 930]] 1.0 7umb TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 5KKRB Q6VAB6 650 932 950.0 6U7:1001 Type1.5_Back Pseudo DFGin 6.321 13.655 BLBplus -128.93, 179.91 52.58, 42.95 -101.79, 139.35 57.86, 93.35 75.81, -29.93 out-none out 15.513 Saltbr-none 999.0 HRD-in -70.05, -32.28 58.42, -72.83 none-out-out SNCnoo out-out ActLoopNT-out 9.734 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -86.49, -61.06 APE9-dihe-na -69.5, -38.89 APE8-dihe-out -67.94, -23.77 APE8-rot-na 175.88 APE67-dihe-in -97.86, 0.75 -65.39, -34.36 APE12-dist-out 17.673 APE11-dist-out 15.152 APE10-dist-out 19.8 APE9-dist-out 10.565 None None None XRAY 3.509 0.252 0.287 B 319 272 11 0 0 5 [[665, 930]] 1.0 5kkr TKL_KSR2_HUMAN TKL 1.1e-70 244.1 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TYR ERBB3 ERBB3_HUMAN 3KEXA P21860 698 994 1342.0 ANP:60001 ATPlike Pseudo DFGin 5.66 12.692 BLBplus -136.97, 172.9 58.22, 40.12 -96.04, 155.03 48.2, 92.31 69.55, -19.76 out-na out 15.235 Saltbr-na 999.0 HRD-in -90.16, -54.52 74.78, -7.72 na-out-out SNCaoo out-out ActLoopNT-out 6.728 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.57 APE8-dihe-out -99.2, 24.49 APE8-rot-na 333.43 APE67-dihe-in -74.24, 11.38 -68.56, -18.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.774 None None None XRAY 2.797 0.243 0.283 A 325 292 5 0 0 5 [[709, 967]] 1.0 3kex TYR_ERBB3_HUMAN TYR 6e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3KEXB P21860 698 988 1342.0 ANP:60002 ATPlike Pseudo DFGin 5.652 12.673 BLBplus -137.46, 172.26 58.51, 39.18 -94.14, 155.27 47.87, 93.32 68.94, -19.33 out-na out 15.232 Saltbr-na 999.0 HRD-in -90.89, -54.23 74.6, -7.22 na-out-out SNCaoo out-out ActLoopNT-out 6.727 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.38 APE8-dihe-out -51.8, -10.63 APE8-rot-na 330.98 APE67-dihe-in -73.43, 11.3 -67.12, -27.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.215 None None None XRAY 2.797 0.243 0.283 B 325 283 7 0 0 7 [[709, 967]] 1.0 3kex TYR_ERBB3_HUMAN TYR 6e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIWA P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.665 12.919 BLBplus -124.68, 170.7 61.91, 32.93 -86.72, 138.2 53.99, 90.7 80.0, -6.46 out-na out 15.12 Saltbr-na 999.0 HRD-in -76.0, -53.69 67.87, 2.11 na-out-none SNCaon out-none ActLoopNT-out 6.632 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -2.58 APE8-rot-na 28.66 APE67-dihe-in -88.2, -5.19 -70.28, -23.24 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.233 0.287 A 326 269 12 0 0 12 [[709, 967]] 1.0 4riw TYR_ERBB3_HUMAN TYR 6.1e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIWC P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.618 13.032 BLBplus -125.06, 170.64 62.1, 33.09 -86.97, 138.33 54.47, 90.5 80.01, -6.38 out-na out 15.49 Saltbr-na 999.0 HRD-in -75.9, -53.21 67.39, 0.69 na-out-out SNCaoo out-out ActLoopNT-out 6.393 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -113.39, 20.05 APE9-dihe-in -68.39, 127.6 APE8-dihe-out -63.99, -4.42 APE8-rot-na 333.17 APE67-dihe-in -86.76, -6.22 -71.15, -22.24 APE12-dist-na 21.544 APE11-dist-na 20.419 APE10-dist-na 15.408 APE9-dist-out 10.083 None None None XRAY 3.1 0.233 0.287 C 326 275 6 0 0 0 [[709, 967]] 1.0 4riw TYR_ERBB3_HUMAN TYR 6.1e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3LMGA P21860 699 978 1342.0 ANP:60301 ATPlike Pseudo DFGin 5.728 12.964 BLBplus -117.83, 170.87 63.58, 24.7 -69.26, 132.03 43.93, 98.75 70.87, 7.13 out-na out 15.578 Saltbr-na 999.0 HRD-in -64.67, -52.37 74.61, 1.05 na-out-out SNCaoo out-out ActLoopNT-out 6.623 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 104.53 APE8-dihe-out -45.34, -17.97 APE8-rot-na 330.0 APE67-dihe-in -71.66, -7.63 -57.32, -31.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.464 None None None XRAY 2.8 0.255 0.285 A 344 268 12 0 0 9 [[709, 967]] 1.0 3lmg TYR_ERBB3_HUMAN TYR 7.3e-80 274.0 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3LMGB P21860 699 978 1342.0 ANP:60301 ATPlike Pseudo DFGin 5.789 12.844 BLBplus -113.43, 165.54 66.13, 22.95 -73.3, 147.22 48.63, 94.29 81.01, -18.45 out-na out 15.381 Saltbr-na 999.0 HRD-in -77.74, -52.9 74.69, -13.1 na-out-none SNCaon out-none ActLoopNT-out 6.805 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -22.84 APE8-rot-na 330.0 APE67-dihe-in -67.55, -12.53 -55.83, -37.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.255 0.285 B 344 268 12 0 0 9 [[709, 967]] 1.0 3lmg TYR_ERBB3_HUMAN TYR 7.3e-80 274.0 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIYA P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.753 12.868 BLBplus -123.9, 168.71 62.98, 31.45 -82.39, 142.59 52.35, 86.17 78.8, -6.78 out-na out 15.044 Saltbr-na 999.0 HRD-in -75.26, -54.75 69.16, 2.85 na-out-none SNCaon out-none ActLoopNT-out 6.45 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -9.22 APE8-rot-na 31.12 APE67-dihe-in -85.56, -1.17 -67.69, -25.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 E928G None None XRAY 2.981 0.221 0.267 A 326 269 12 0 0 12 [[709, 967]] 1.0 4riy TYR_ERBB3_HUMAN TYR 1.3e-79 273.1 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIYC P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.577 13.185 BLBplus -124.39, 168.66 63.11, 31.61 -82.48, 141.95 52.91, 86.81 78.36, -7.08 out-na out 15.605 Saltbr-na 999.0 HRD-in -74.67, -54.96 68.56, 2.02 na-out-out SNCaoo out-out ActLoopNT-out 6.525 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -99.97, 8.97 APE9-dihe-in -62.65, 132.93 APE8-dihe-out -66.25, -9.79 APE8-rot-na 341.07 APE67-dihe-in -85.25, -1.58 -67.21, -25.34 APE12-dist-na 22.285 APE11-dist-na 20.535 APE10-dist-na 15.613 APE9-dist-out 10.163 E928G None None XRAY 2.981 0.221 0.267 C 326 275 6 0 0 0 [[709, 967]] 1.0 4riy TYR_ERBB3_HUMAN TYR 1.3e-79 273.1 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIXA P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.534 12.788 BLBplus -125.2, 170.11 60.89, 28.84 -82.14, 140.77 56.51, 90.87 77.72, -6.25 out-na out 15.04 Saltbr-na 999.0 HRD-in -77.1, -53.12 66.52, 0.72 na-out-none SNCaon out-none ActLoopNT-out 6.513 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -5.5 APE8-rot-na 30.9 APE67-dihe-in -82.84, -10.3 -67.07, -25.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q809R None None XRAY 3.1 0.21 0.258 A 326 269 12 0 0 12 [[709, 967]] 1.0 4rix TYR_ERBB3_HUMAN TYR 9.7e-80 273.5 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIXC P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.557 13.116 BLBplus -126.64, 170.72 61.2, 28.92 -82.69, 140.73 56.76, 91.32 77.44, -6.2 out-na out 15.473 Saltbr-na 999.0 HRD-in -76.48, -52.61 66.58, -0.13 na-out-out SNCaoo out-out ActLoopNT-out 6.372 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -112.15, 5.58 APE9-dihe-in -58.87, 135.06 APE8-dihe-out -71.85, -6.39 APE8-rot-na 348.17 APE67-dihe-in -82.4, -10.58 -67.81, -25.66 APE12-dist-na 21.658 APE11-dist-na 20.612 APE10-dist-na 15.605 APE9-dist-out 9.969 Q809R None None XRAY 3.1 0.21 0.258 C 326 275 6 0 0 0 [[709, 967]] 1.0 4rix TYR_ERBB3_HUMAN TYR 9.7e-80 273.5 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 6OP9A P21860 699 979 1342.0 DB8:61101 Type1 Pseudo DFGin 5.807 13.202 BLBplus -112.2, 168.23 74.7, 17.55 -72.83, 138.03 47.72, 93.08 81.75, -11.37 out-na out 15.256 Saltbr-na 999.0 HRD-in -65.5, -60.79 78.74, 0.36 na-out-out SNCaoo out-out ActLoopNT-out 6.69 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -72.9, -25.26 APE9-dihe-in -116.6, 159.4 APE8-dihe-in -83.21, 75.09 APE8-rot-na 31.73 APE67-dihe-in -70.29, -6.2 -48.51, -45.47 APE12-dist-na 999.0 APE11-dist-na 18.44 APE10-dist-na 14.221 APE9-dist-in 7.834 None None None XRAY 2.501 0.173 0.23 A 328 276 5 0 0 5 [[709, 967]] 1.0 6op9 TYR_ERBB3_HUMAN TYR 6.2e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR JAK1-1 JAK1_HUMAN 4L01A P23458 565 850 1154.0 No_ligand No_ligand Pseudo DFGin 6.792 12.079 None -73.75, -179.09 -73.9, 162.14 -73.89, -15.61 344.71, 28.42 67.96, -153.13 in-na in 9.543 Saltbr-na 999.0 HRD-in -87.9, -71.89 94.16, -0.24 na-out-out SNCaoo out-out ActLoopNT-out 7.954 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.86, -39.57 APE9-dihe-out -58.05, -29.58 APE8-dihe-out -81.67, -7.08 APE8-rot-na 199.85 APE67-dihe-out -101.51, 19.28 -61.73, 134.72 APE12-dist-na 9.341 APE11-dist-na 11.755 APE10-dist-na 15.957 APE9-dist-out 11.126 V658F None None XRAY 1.9 0.204 0.233 A 304 274 12 0 0 0 [[583, 847], [875, 1151]] 2.0 4l01 TYR_JAK1-1_HUMAN TYR 9.9e-61 211.3 2 260 259 738 739 740 742 744 622 638 642 711 713 712 714 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
TYR JAK1-1 JAK1_HUMAN 4L01B P23458 565 849 1154.0 No_ligand No_ligand Pseudo DFGin 6.823 11.872 None -76.74, -176.42 -72.49, 166.45 -77.53, -11.38 359.0, 15.1 69.24, -153.25 in-na in 8.893 Saltbr-na 999.0 HRD-in -86.59, -73.54 93.9, -0.47 na-out-out SNCaoo out-out ActLoopNT-out 8.016 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -57.69, -39.64 APE9-dihe-out -57.55, -28.87 APE8-dihe-out -85.94, -3.15 APE8-rot-na 200.27 APE67-dihe-out -99.61, 21.88 -63.69, 136.29 APE12-dist-na 9.299 APE11-dist-na 11.695 APE10-dist-na 15.846 APE9-dist-out 11.03 V658F None None XRAY 1.9 0.204 0.233 B 304 274 11 0 0 0 [[583, 847], [875, 1151]] 2.0 4l01 TYR_JAK1-1_HUMAN TYR 9.9e-61 211.3 2 260 259 738 739 740 742 744 622 638 642 711 713 712 714 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
TYR JAK1-1 JAK1_HUMAN 4L00A P23458 564 850 1154.0 No_ligand No_ligand Pseudo DFGin 6.912 11.988 None -76.07, -177.45 -75.3, 165.45 -78.74, -7.85 349.06, 24.36 63.89, -153.3 in-na in 9.561 Saltbr-na 999.0 HRD-in -93.36, -71.42 93.51, 0.78 na-out-out SNCaoo out-out ActLoopNT-out 7.961 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.21, -40.39 APE9-dihe-out -55.79, -30.01 APE8-dihe-out -85.56, 0.43 APE8-rot-na 187.12 APE67-dihe-out -101.03, 20.07 -69.52, 138.76 APE12-dist-na 9.496 APE11-dist-na 11.88 APE10-dist-na 16.127 APE9-dist-out 11.163 None None None XRAY 1.8 0.171 0.203 A 304 277 10 0 0 0 [[583, 847], [875, 1151]] 2.0 4l00 TYR_JAK1-1_HUMAN TYR 5.2e-61 212.2 2 260 259 738 739 740 742 744 622 638 642 711 713 712 714 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
TYR JAK1-1 JAK1_HUMAN 4L00B P23458 565 850 1154.0 No_ligand No_ligand Pseudo DFGin 6.872 11.974 None -78.39, -173.09 -77.68, 164.49 -74.46, -8.56 347.77, 22.41 63.58, -153.63 in-na in 8.973 Saltbr-na 999.0 HRD-in -90.15, -72.75 94.75, 3.66 na-out-out SNCaoo out-out ActLoopNT-out 7.929 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.66, -39.95 APE9-dihe-out -56.84, -31.4 APE8-dihe-out -81.07, -3.08 APE8-rot-na 200.04 APE67-dihe-out -104.62, 20.8 -63.46, 134.32 APE12-dist-na 9.37 APE11-dist-na 11.85 APE10-dist-na 15.911 APE9-dist-out 11.081 None None None XRAY 1.8 0.171 0.203 B 304 278 8 0 0 0 [[583, 847], [875, 1151]] 2.0 4l00 TYR_JAK1-1_HUMAN TYR 5.2e-61 212.2 2 260 259 738 739 740 742 744 622 638 642 711 713 712 714 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
TYR JAK2-1 JAK2_HUMAN 5I4NA O60674 537 809 1132.0 ATP:61000 ATPlike Pseudo DFGin 5.668 13.386 None -68.19, 172.29 -64.41, 158.19 -73.31, -26.63 342.84, 34.8 77.82, -169.16 out-na out 11.405 Saltbr-na 999.0 HRD-in -78.6, -60.98 86.96, 3.87 na-out-out SNCaoo out-out ActLoopNT-out 8.681 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.12, -41.49 APE9-dihe-out -58.18, -29.35 APE8-dihe-out -88.11, 6.74 APE8-rot-na 290.83 APE67-dihe-out -103.83, 26.01 -65.06, 135.53 APE12-dist-na 10.037 APE11-dist-na 11.7 APE10-dist-na 16.278 APE9-dist-out 12.372 E596A,V617F,W659A,W777A,F794H None None XRAY 1.54 0.174 0.193 A 290 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5i4n TYR_JAK2-1_HUMAN TYR 7.1e-64 221.5 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVRA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 5.766 13.376 None -77.86, -178.54 -72.61, 163.95 -75.06, -27.39 334.11, 39.64 77.27, -166.65 out-na out 11.782 Saltbr-na 999.0 HRD-in -74.66, -57.27 90.8, -3.55 na-out-out SNCaoo out-out ActLoopNT-out 8.537 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.48, -33.68 APE9-dihe-out -63.8, -34.8 APE8-dihe-out -85.1, 11.44 APE8-rot-na 293.02 APE67-dihe-out -101.64, 24.24 -66.8, 135.55 APE12-dist-na 9.675 APE11-dist-na 11.473 APE10-dist-na 16.037 APE9-dist-out 12.028 V617F,W777A,F794H None None XRAY 2.0 0.183 0.229 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4fvr TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVQA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 6.411 13.531 None -82.38, -178.3 -71.29, 157.18 -64.23, -31.16 342.38, 32.32 77.45, -167.94 out-na out 10.357 Saltbr-na 999.0 HRD-in -81.79, -59.57 93.66, -10.87 na-out-out SNCaoo out-out ActLoopNT-out 9.094 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.14, -35.28 APE9-dihe-out -67.39, -22.98 APE8-dihe-out -92.26, 6.93 APE8-rot-na 290.03 APE67-dihe-out -106.47, 27.81 -64.4, 133.6 APE12-dist-na 9.912 APE11-dist-na 11.487 APE10-dist-na 16.075 APE9-dist-out 12.378 W659A,W777A,F794H None None XRAY 1.75 0.176 0.199 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4fvq TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08A O60674 537 810 1132.0 ATP:901 ATPlike Pseudo DFGin 6.598 13.736 None -72.21, 176.69 -66.6, 164.57 -72.8, -15.2 349.18, 27.02 73.34, -163.25 in-na in 9.4 Saltbr-na 999.0 HRD-in -80.72, -74.63 111.24, -16.83 na-out-out SNCaoo out-out ActLoopNT-out 9.474 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -55.86, -37.52 APE9-dihe-out -72.05, -28.92 APE8-dihe-out -74.69, -10.21 APE8-rot-na 283.12 APE67-dihe-out -93.42, 18.23 -54.81, 139.34 APE12-dist-na 9.92 APE11-dist-na 11.859 APE10-dist-na 16.352 APE9-dist-out 12.53 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 A 289 270 4 0 0 0 [[545, 807], [849, 1125]] 2.0 8c08 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08B O60674 536 810 1132.0 ATP:901 ATPlike Pseudo DFGin 5.646 13.539 None -63.04, -178.12 -72.48, 164.14 -59.19, -39.37 337.51, 34.58 89.58, -173.09 out-na out 12.178 Saltbr-na 999.0 HRD-in -76.08, -63.96 89.49, 0.26 na-out-out SNCaoo out-out ActLoopNT-out 8.73 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.09, -36.29 APE9-dihe-out -67.21, -14.45 APE8-dihe-out -97.09, 0.9 APE8-rot-na 279.42 APE67-dihe-out -95.31, 21.21 -63.75, 135.54 APE12-dist-na 10.848 APE11-dist-na 11.837 APE10-dist-na 16.6 APE9-dist-out 12.658 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 B 289 269 6 0 0 0 [[545, 807], [849, 1125]] 2.0 8c08 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA4B O60674 536 809 1132.0 No_ligand No_ligand Pseudo DFGin 7.016 13.629 None -84.33, -175.92 -78.92, 160.47 -67.97, -29.51 344.52, 29.43 84.02, -159.01 out-na out 10.548 Saltbr-na 999.0 HRD-in -80.56, -60.88 93.85, -0.35 na-out-out SNCaoo out-out ActLoopNT-out 9.253 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.77, -41.18 APE9-dihe-out -60.58, -30.76 APE8-dihe-out -85.29, 2.29 APE8-rot-na 288.75 APE67-dihe-out -100.46, 22.84 -59.03, 138.57 APE12-dist-na 9.67 APE11-dist-na 11.398 APE10-dist-na 15.935 APE9-dist-out 12.667 W659A,W777A,F794H None None XRAY 2.1 0.219 0.274 B 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8ba4 TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVPA O60674 536 809 1132.0 No_ligand No_ligand Pseudo DFGin 7.893 13.09 None -91.01, 179.45 -75.79, 153.56 -78.3, -11.29 26.93, 143.21 73.75, -158.65 out-na out 13.166 Saltbr-na 999.0 HRD-in -83.21, -62.84 93.75, -4.6 na-out-out SNCaoo out-out ActLoopNT-out 9.629 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.0, -41.33 APE9-dihe-out -58.79, -30.31 APE8-dihe-out -86.85, 3.46 APE8-rot-na 297.22 APE67-dihe-out -102.61, 25.98 -63.62, 134.65 APE12-dist-na 9.883 APE11-dist-na 11.675 APE10-dist-na 16.144 APE9-dist-out 12.543 W659A,W777A,F794H None None XRAY 2.01 0.181 0.212 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4fvp TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C09A O60674 538 809 1132.0 No_ligand No_ligand Pseudo DFGin 7.053 13.253 None -86.22, -176.26 -73.29, 161.33 -72.41, -30.09 344.35, 29.81 80.16, -162.74 out-na out 11.184 Saltbr-na 999.0 HRD-in -80.44, -66.09 97.2, -4.64 na-out-out SNCaoo out-out ActLoopNT-out 9.079 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.51, -34.73 APE9-dihe-out -64.77, -31.42 APE8-dihe-out -84.71, 1.64 APE8-rot-na 292.35 APE67-dihe-out -99.58, 28.31 -60.08, 137.86 APE12-dist-na 9.864 APE11-dist-na 11.557 APE10-dist-na 16.122 APE9-dist-out 12.483 I559F,W659A,W777A,F794H None None XRAY 1.9 0.223 0.257 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8c09 TYR_JAK2-1_HUMAN TYR 1.3e-63 220.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6G3CA O60674 537 808 1132.0 EKT:901 Type1 Pseudo DFGin 7.929 13.297 None -92.88, -174.23 -74.55, 160.0 -77.81, -9.76 27.51, 143.79 70.13, -167.0 in-na in 9.462 Saltbr-na 999.0 HRD-in -89.47, -61.45 91.27, -4.79 na-out-out SNCaoo out-out ActLoopNT-out 9.753 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.76, -39.79 APE9-dihe-out -61.91, -29.13 APE8-dihe-out -80.12, 0.2 APE8-rot-na 289.19 APE67-dihe-out -101.75, 22.48 -69.62, 136.72 APE12-dist-na 9.767 APE11-dist-na 11.566 APE10-dist-na 16.154 APE9-dist-out 12.702 W659A,W777A,F794H None None XRAY 1.6 0.196 0.22 A 272 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6g3c TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6G3CB O60674 537 808 1132.0 EKT:901 Type1 Pseudo DFGin 7.99 13.415 None -91.77, -175.11 -73.45, 159.45 -76.52, -11.86 28.49, 143.52 73.41, -164.04 in-na in 9.643 Saltbr-na 999.0 HRD-in -89.94, -61.82 90.1, -3.95 na-out-out SNCaoo out-out ActLoopNT-out 9.693 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.88, -39.41 APE9-dihe-out -62.88, -28.18 APE8-dihe-out -81.21, 1.24 APE8-rot-na 288.18 APE67-dihe-out -102.69, 23.29 -70.43, 136.03 APE12-dist-na 9.769 APE11-dist-na 11.58 APE10-dist-na 16.138 APE9-dist-out 12.69 W659A,W777A,F794H None None XRAY 1.6 0.196 0.22 B 272 268 4 0 0 0 [[545, 807], [849, 1125]] 2.0 6g3c TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6D2IA O60674 536 808 1132.0 35R:901 Type1 Pseudo DFGin 6.552 13.651 None -85.6, -168.64 -71.02, 159.25 -67.8, -19.61 341.93, 32.5 72.61, -145.53 in-na in 9.639 Saltbr-na 999.0 HRD-in -88.15, -70.56 100.36, -8.76 na-out-out SNCaoo out-out ActLoopNT-out 9.7 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.19, -30.63 APE9-dihe-out -73.76, -13.56 APE8-dihe-out -89.52, 2.58 APE8-rot-na 300.29 APE67-dihe-out -99.98, 28.53 -66.76, 135.82 APE12-dist-na 10.52 APE11-dist-na 11.514 APE10-dist-na 16.315 APE9-dist-out 13.019 W659A,W777A,F794H None None XRAY 3.192 0.272 0.29 A 273 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6d2i TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6D2IB O60674 537 808 1132.0 35R:901 Type1 Pseudo DFGin 6.745 13.508 None -83.97, -172.62 -69.78, 158.02 -65.46, -20.62 341.26, 32.34 71.79, -145.54 in-na in 9.436 Saltbr-na 999.0 HRD-in -84.58, -69.97 97.0, -6.55 na-out-out SNCaoo out-out ActLoopNT-out 9.449 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.97, -30.79 APE9-dihe-out -72.59, -17.09 APE8-dihe-out -89.77, 2.61 APE8-rot-na 301.92 APE67-dihe-out -99.31, 27.86 -67.19, 135.78 APE12-dist-na 10.586 APE11-dist-na 11.89 APE10-dist-na 16.65 APE9-dist-out 12.896 W659A,W777A,F794H None None XRAY 3.192 0.272 0.29 B 273 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6d2i TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B8NA O60674 536 809 1132.0 AQG:904 Type1 Pseudo DFGin 6.992 13.559 None -86.6, 176.83 -72.07, 163.0 -83.55, -11.71 8.83, 7.64 73.11, -166.45 out-na out 10.223 Saltbr-na 999.0 HRD-in -77.47, -60.54 92.78, -1.1 na-out-out SNCaoo out-out ActLoopNT-out 9.255 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.27, -38.06 APE9-dihe-out -61.66, -30.26 APE8-dihe-out -80.2, 3.05 APE8-rot-na 289.81 APE67-dihe-out -99.17, 33.25 -63.6, 138.44 APE12-dist-na 9.554 APE11-dist-na 11.448 APE10-dist-na 15.97 APE9-dist-out 12.453 W659A,W777A,F794H None None XRAY 2.0 0.211 0.255 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8b8n TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B8UA O60674 536 809 1132.0 T7I:902 Type1 Pseudo DFGin 7.821 13.298 None -86.5, 168.2 -72.83, 159.81 -77.39, -5.69 29.32, 142.66 68.85, -165.5 in-na in 9.637 Saltbr-na 999.0 HRD-in -85.53, -63.36 91.05, -0.77 na-out-out SNCaoo out-out ActLoopNT-out 9.586 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.74, -40.18 APE9-dihe-out -60.78, -27.05 APE8-dihe-out -85.5, 2.2 APE8-rot-na 288.85 APE67-dihe-out -105.88, 26.49 -64.53, 136.9 APE12-dist-na 9.839 APE11-dist-na 11.543 APE10-dist-na 16.135 APE9-dist-out 12.651 W659A,W777A,F794H None None XRAY 1.5 0.224 0.259 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8b8u TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B8UB O60674 538 809 1132.0 T7I:903 Type1 Pseudo DFGin 7.684 13.367 None -85.95, 172.23 -73.23, 159.57 -79.19, -7.74 28.18, 144.77 71.86, -165.96 in-na in 9.871 Saltbr-na 999.0 HRD-in -85.44, -62.47 91.56, -1.37 na-out-out SNCaoo out-out ActLoopNT-out 9.405 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.42, -39.8 APE9-dihe-out -61.59, -26.48 APE8-dihe-out -85.69, -0.76 APE8-rot-na 289.8 APE67-dihe-out -104.95, 23.87 -61.36, 134.02 APE12-dist-na 9.893 APE11-dist-na 11.487 APE10-dist-na 16.106 APE9-dist-out 12.548 W659A,W777A,F794H None None XRAY 1.5 0.224 0.259 B 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8b8u TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA2A O60674 536 810 1132.0 Q9X:907 Type1 Pseudo DFGin 5.707 13.272 None -74.82, 174.75 -67.11, 161.11 -77.71, -21.19 340.67, 34.41 73.6, -166.64 out-na out 11.657 Saltbr-na 999.0 HRD-in -83.09, -59.59 87.04, -0.99 na-out-out SNCaoo out-out ActLoopNT-out 8.949 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.59, -40.16 APE9-dihe-out -57.17, -31.99 APE8-dihe-out -85.57, 4.75 APE8-rot-na 288.77 APE67-dihe-out -102.79, 29.41 -64.21, 136.1 APE12-dist-na 9.735 APE11-dist-na 11.432 APE10-dist-na 16.018 APE9-dist-out 12.283 W659A,W777A,F794H None None XRAY 1.5 0.178 0.204 A 289 275 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8ba2 TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA4A O60674 536 809 1132.0 Q8U:901 Type1 Pseudo DFGin 7.944 13.412 None -71.69, 172.79 -67.86, 161.07 -79.48, -19.97 29.54, 146.52 81.3, -166.68 in-na in 9.788 Saltbr-na 999.0 HRD-in -74.34, -63.4 91.62, 2.89 na-out-out SNCaoo out-out ActLoopNT-out 8.59 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.98, -39.28 APE9-dihe-out -56.91, -30.54 APE8-dihe-out -86.08, -1.03 APE8-rot-na 290.49 APE67-dihe-out -99.32, 21.83 -60.56, 137.6 APE12-dist-na 9.925 APE11-dist-na 11.647 APE10-dist-na 16.144 APE9-dist-out 12.327 W659A,W777A,F794H None None XRAY 2.1 0.219 0.274 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8ba4 TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7F7WA O60674 536 810 1132.0 36H:1000 Type1 Pseudo DFGin 6.915 13.796 None -91.54, 171.73 -67.57, 155.24 -69.34, -22.33 351.29, 21.05 78.83, -168.1 out-na out 10.169 Saltbr-na 999.0 HRD-in -84.02, -62.23 90.48, 0.05 na-out-out SNCaoo out-out ActLoopNT-out 9.723 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.04, -35.76 APE9-dihe-out -66.77, -25.16 APE8-dihe-out -85.21, 3.67 APE8-rot-na 284.34 APE67-dihe-out -100.56, 25.85 -66.38, 135.35 APE12-dist-na 9.689 APE11-dist-na 11.473 APE10-dist-na 16.032 APE9-dist-out 12.653 None None None XRAY 1.83 0.208 0.238 A 275 275 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7f7w TYR_JAK2-1_HUMAN TYR 5.3e-64 222.0 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7F7WB O60674 536 810 1132.0 36H:1000 Type1 Pseudo DFGin 6.903 13.687 None -84.95, 175.07 -74.42, 156.63 -70.62, -23.21 351.87, 21.25 77.0, -167.15 out-na out 10.252 Saltbr-na 999.0 HRD-in -79.03, -66.0 95.6, -1.12 na-out-out SNCaoo out-out ActLoopNT-out 9.495 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.33, -37.68 APE9-dihe-out -69.53, -21.97 APE8-dihe-out -87.12, 4.19 APE8-rot-na 285.11 APE67-dihe-out -99.09, 24.95 -67.63, 136.04 APE12-dist-na 9.704 APE11-dist-na 11.491 APE10-dist-na 16.017 APE9-dist-out 12.671 None None None XRAY 1.83 0.208 0.238 B 275 275 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7f7w TYR_JAK2-1_HUMAN TYR 5.3e-64 222.0 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B99A O60674 536 809 1132.0 SKE:1003 Type1 Pseudo DFGin 5.829 13.19 None -69.78, 174.05 -70.57, 162.32 -72.88, -28.63 342.75, 30.69 79.14, -167.36 out-na out 11.614 Saltbr-na 999.0 HRD-in -83.46, -62.07 90.64, -3.52 na-out-out SNCaoo out-out ActLoopNT-out 8.844 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.87, -40.42 APE9-dihe-out -54.81, -33.54 APE8-dihe-out -85.07, 3.29 APE8-rot-na 283.44 APE67-dihe-out -103.17, 28.18 -66.12, 134.93 APE12-dist-na 9.764 APE11-dist-na 11.367 APE10-dist-na 15.959 APE9-dist-out 12.16 W777A,F794H None None XRAY 1.6 0.19 0.211 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8b99 TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B9EA O60674 536 809 1132.0 Q7F:1003 Type1 Pseudo DFGin 5.769 13.226 None -72.27, 175.04 -67.31, 162.54 -76.41, -26.42 340.6, 33.67 78.05, -163.23 out-na out 11.726 Saltbr-na 999.0 HRD-in -83.9, -60.17 88.41, -6.41 na-out-out SNCaoo out-out ActLoopNT-out 8.95 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.18, -39.02 APE9-dihe-out -59.74, -28.13 APE8-dihe-out -86.36, 6.28 APE8-rot-na 284.57 APE67-dihe-out -105.41, 26.85 -68.63, 134.78 APE12-dist-na 9.613 APE11-dist-na 11.316 APE10-dist-na 15.854 APE9-dist-out 12.106 W777A,F794H None None XRAY 1.5 0.17 0.194 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8b9e TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BABA O60674 536 809 1132.0 Q8N:908 Type1 Pseudo DFGin 5.783 13.347 None -82.44, 178.74 -69.43, 159.24 -76.71, -21.64 341.13, 33.08 75.74, -169.92 out-na out 11.796 Saltbr-na 999.0 HRD-in -85.23, -57.58 89.38, -3.23 na-out-out SNCaoo out-out ActLoopNT-out 9.079 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.14, -39.62 APE9-dihe-out -58.1, -35.37 APE8-dihe-out -80.74, 3.58 APE8-rot-na 288.39 APE67-dihe-out -100.89, 27.42 -62.52, 138.56 APE12-dist-na 9.881 APE11-dist-na 11.499 APE10-dist-na 16.122 APE9-dist-out 12.537 W777A,F794H None None XRAY 1.55 0.176 0.203 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bab TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BAKA O60674 536 809 1132.0 AD5:906 Type1 Pseudo DFGin 5.9 13.485 None -79.74, 176.09 -70.26, 155.83 -67.8, -33.14 338.52, 35.12 82.51, -172.71 out-na out 11.743 Saltbr-na 999.0 HRD-in -82.49, -60.1 89.16, -0.66 na-out-out SNCaoo out-out ActLoopNT-out 9.022 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.79, -43.24 APE9-dihe-out -56.17, -32.1 APE8-dihe-out -84.4, 4.03 APE8-rot-na 284.51 APE67-dihe-out -100.67, 27.47 -64.95, 137.17 APE12-dist-na 9.883 APE11-dist-na 11.588 APE10-dist-na 16.141 APE9-dist-out 12.616 W777A,F794H None None XRAY 1.65 0.185 0.207 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bak TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C0AA O60674 536 809 1132.0 T7I:902 Type1 Pseudo DFGin 7.565 13.354 None -83.75, 166.81 -71.24, 158.41 -74.12, -10.51 25.45, 142.36 78.43, -168.66 in-na in 9.559 Saltbr-na 999.0 HRD-in -83.22, -65.0 92.23, 1.81 na-out-out SNCaoo out-out ActLoopNT-out 9.601 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -71.23, -34.89 APE9-dihe-out -65.21, -28.5 APE8-dihe-out -84.82, 8.34 APE8-rot-na 293.37 APE67-dihe-out -106.96, 23.1 -69.15, 131.91 APE12-dist-na 9.892 APE11-dist-na 11.624 APE10-dist-na 16.147 APE9-dist-out 12.571 W659A,R683S,W777A,F794H None None XRAY 1.7 0.196 0.237 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8c0a TYR_JAK2-1_HUMAN TYR 1.5e-64 223.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C0AB O60674 536 808 1132.0 T7I:902 Type1 Pseudo DFGin 7.485 13.398 None -84.77, 172.51 -72.53, 156.76 -75.35, -8.78 26.64, 140.87 71.28, -164.53 in-na in 9.805 Saltbr-na 999.0 HRD-in -81.32, -65.94 88.05, 6.45 na-out-out SNCaoo out-out ActLoopNT-out 9.414 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.73, -37.68 APE9-dihe-out -64.41, -27.87 APE8-dihe-out -85.03, 1.77 APE8-rot-na 284.08 APE67-dihe-out -105.43, 24.1 -65.54, 134.17 APE12-dist-na 9.772 APE11-dist-na 11.459 APE10-dist-na 16.089 APE9-dist-out 12.496 W659A,R683S,W777A,F794H None None XRAY 1.7 0.196 0.237 B 289 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8c0a TYR_JAK2-1_HUMAN TYR 1.5e-64 223.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WIJA O60674 536 809 1132.0 AQG:901 Type1 Pseudo DFGin 7.856 13.566 None -91.12, 177.94 -71.51, 155.95 -79.01, -8.25 29.98, 143.91 73.76, -166.11 in-na in 9.917 Saltbr-na 999.0 HRD-in -72.47, -68.91 101.27, -5.66 na-out-out SNCaoo out-out ActLoopNT-out 9.306 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -74.59, -26.98 APE9-dihe-out -64.74, -27.71 APE8-dihe-out -87.29, 3.84 APE8-rot-na 291.39 APE67-dihe-out -100.01, 30.88 -65.27, 134.93 APE12-dist-na 9.617 APE11-dist-na 11.495 APE10-dist-na 15.994 APE9-dist-out 12.51 W659A,W777A,F794H None None XRAY 2.04 0.209 0.231 A 277 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5wij TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WIKB O60674 536 809 1132.0 584:901 Type1 Pseudo DFGin 8.2 13.477 None -86.83, -177.1 -74.98, 154.5 -75.92, -8.34 30.63, 142.46 77.38, -163.2 out-na out 10.015 Saltbr-na 999.0 HRD-in -75.13, -71.22 102.4, -1.09 na-out-out SNCaoo out-out ActLoopNT-out 9.412 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.94, -26.86 APE9-dihe-out -70.71, -25.41 APE8-dihe-out -85.62, 4.24 APE8-rot-na 286.3 APE67-dihe-out -97.88, 28.27 -66.61, 137.0 APE12-dist-na 9.663 APE11-dist-na 11.418 APE10-dist-na 16.055 APE9-dist-out 12.594 W659A,W777A,F794H None None XRAY 2.6 0.211 0.251 B 277 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5wik TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WILA O60674 536 809 1132.0 YDJ:901 Type1 Pseudo DFGin 7.531 13.717 None -83.87, 163.34 -72.42, 163.18 -87.02, -3.44 24.44, 145.33 75.07, -167.72 out-na out 10.46 Saltbr-na 999.0 HRD-in -86.92, -55.39 94.23, -3.93 na-out-out SNCaoo out-out ActLoopNT-out 9.665 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.97, -30.77 APE9-dihe-out -75.41, -19.35 APE8-dihe-out -84.61, 10.2 APE8-rot-na 287.01 APE67-dihe-out -99.8, 25.99 -70.86, 137.89 APE12-dist-na 9.547 APE11-dist-na 11.481 APE10-dist-na 16.04 APE9-dist-out 12.692 W659A,W777A,F794H None None XRAY 2.2 0.201 0.231 A 277 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5wil TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WIMA O60674 536 809 1132.0 35R:901 Type1 Pseudo DFGin 7.752 13.585 None -93.28, 176.5 -38.24, 151.14 -78.63, -21.68 29.2, 149.11 81.15, -169.97 out-na out 10.568 Saltbr-na 999.0 HRD-in -83.09, -66.39 96.8, 0.86 na-out-out SNCaoo out-out ActLoopNT-out 9.85 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -105.18, -10.47 APE9-dihe-out -83.98, -20.52 APE8-dihe-out -80.31, 9.26 APE8-rot-na 299.8 APE67-dihe-out -97.29, 28.98 -67.31, 132.23 APE12-dist-na 9.833 APE11-dist-na 11.542 APE10-dist-na 15.898 APE9-dist-out 12.889 W659A,W777A,F794H None None XRAY 2.55 0.211 0.258 A 277 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5wim TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WINA O60674 536 809 1132.0 SKE:901 Type1 Pseudo DFGin 7.28 13.79 None -75.17, 174.41 -74.13, 155.6 -73.15, -17.87 26.75, 146.64 81.14, -159.91 out-na out 10.815 Saltbr-na 999.0 HRD-in -80.84, -67.43 99.6, -2.16 na-out-out SNCaoo out-out ActLoopNT-out 9.554 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.26, -35.02 APE9-dihe-out -59.2, -25.51 APE8-dihe-out -88.93, -4.07 APE8-rot-na 287.0 APE67-dihe-out -96.98, 26.41 -56.71, 138.03 APE12-dist-na 9.565 APE11-dist-na 11.636 APE10-dist-na 16.025 APE9-dist-out 12.369 W659A,W777A,F794H None None XRAY 2.38 0.221 0.244 A 277 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5win TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5USZA O60674 537 808 1132.0 SKE:901 Type1 Pseudo DFGin 7.147 13.166 None -89.06, 179.4 -74.28, 155.49 -78.9, -12.42 30.8, 143.13 73.21, -171.41 in-na in 9.349 Saltbr-na 999.0 HRD-in -84.39, -62.72 100.4, -8.06 na-out-out SNCaoo out-out ActLoopNT-out 9.803 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.11, -40.08 APE9-dihe-out -63.02, -23.47 APE8-dihe-out -87.07, 3.62 APE8-rot-na 290.38 APE67-dihe-out -103.08, 29.45 -63.02, 136.82 APE12-dist-na 10.118 APE11-dist-na 11.607 APE10-dist-na 16.233 APE9-dist-out 12.889 W659A,W777A,F794H None None XRAY 2.103 0.174 0.224 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5usz TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT0A O60674 537 808 1132.0 35R:903 Type1 Pseudo DFGin 7.594 13.572 None -93.9, 174.39 -69.93, 155.11 -74.3, -13.06 28.06, 143.5 77.21, -173.63 in-na in 9.939 Saltbr-na 999.0 HRD-in -83.57, -61.23 99.02, -12.98 na-out-out SNCaoo out-out ActLoopNT-out 9.966 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.47, -40.74 APE9-dihe-out -59.34, -26.03 APE8-dihe-out -86.35, 4.34 APE8-rot-na 287.5 APE67-dihe-out -101.06, 28.12 -64.23, 136.97 APE12-dist-na 10.005 APE11-dist-na 11.478 APE10-dist-na 16.135 APE9-dist-out 12.932 W659A,W777A,F794H None None XRAY 2.102 0.171 0.226 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5ut0 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT1A O60674 537 808 1132.0 7DZ:905 Type1 Pseudo DFGin 7.378 13.464 None -94.09, -179.69 -75.66, 158.87 -74.76, -6.96 27.15, 144.11 69.28, -174.72 in-na in 9.696 Saltbr-na 999.0 HRD-in -82.87, -62.64 95.48, -12.09 na-out-out SNCaoo out-out ActLoopNT-out 9.812 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.26, -38.46 APE9-dihe-out -62.2, -22.99 APE8-dihe-out -88.42, 4.71 APE8-rot-na 293.57 APE67-dihe-out -104.03, 27.01 -63.75, 135.14 APE12-dist-na 10.11 APE11-dist-na 11.644 APE10-dist-na 16.21 APE9-dist-out 12.883 W659A,W777A,F794H None None XRAY 1.95 0.165 0.202 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5ut1 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT2A O60674 536 808 1132.0 3YT:903 Type1 Pseudo DFGin 7.127 13.312 None -90.0, 179.18 -75.04, 157.7 -78.17, -8.03 29.61, 139.64 71.77, -178.13 in-na in 9.488 Saltbr-na 999.0 HRD-in -87.63, -60.17 95.16, -5.73 na-out-out SNCaoo out-out ActLoopNT-out 9.87 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.9, -38.59 APE9-dihe-out -61.51, -24.95 APE8-dihe-out -88.74, 4.33 APE8-rot-na 288.64 APE67-dihe-out -101.61, 25.26 -63.02, 138.09 APE12-dist-na 10.014 APE11-dist-na 11.555 APE10-dist-na 16.157 APE9-dist-out 12.879 W659A,W777A,F794H None None XRAY 1.75 0.163 0.201 A 289 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5ut2 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT3A O60674 537 808 1132.0 IK1:901 Type1 Pseudo DFGin 7.268 13.402 None -92.6, 177.07 -71.65, 158.85 -79.65, -10.03 26.8, 143.01 73.38, -177.18 in-na in 9.682 Saltbr-na 999.0 HRD-in -85.94, -61.54 97.51, -8.49 na-out-out SNCaoo out-out ActLoopNT-out 10.02 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.63, -39.44 APE9-dihe-out -66.05, -19.54 APE8-dihe-out -89.06, 2.9 APE8-rot-na 290.51 APE67-dihe-out -104.18, 27.32 -64.34, 136.22 APE12-dist-na 9.99 APE11-dist-na 11.578 APE10-dist-na 16.192 APE9-dist-out 12.996 W659A,W777A,F794H None None XRAY 1.501 0.156 0.17 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5ut3 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT4A O60674 537 809 1132.0 DQX:901 Type1 Pseudo DFGin 7.46 13.285 None -91.51, 174.25 -72.2, 155.17 -81.53, -6.98 30.25, 144.04 71.5, -173.67 in-na in 9.739 Saltbr-na 999.0 HRD-in -82.44, -62.81 97.57, -6.96 na-out-out SNCaoo out-out ActLoopNT-out 9.595 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.04, -37.57 APE9-dihe-out -62.17, -24.8 APE8-dihe-out -89.02, 2.73 APE8-rot-na 291.23 APE67-dihe-out -103.04, 31.05 -61.52, 137.36 APE12-dist-na 9.874 APE11-dist-na 11.628 APE10-dist-na 16.146 APE9-dist-out 12.746 W659A,W777A,F794H None None XRAY 2.0 0.18 0.22 A 289 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5ut4 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT5A O60674 537 808 1132.0 2HB:905 Type1 Pseudo DFGin 7.189 13.293 None -93.16, 174.58 -69.71, 153.91 -76.54, -10.06 29.7, 141.93 72.88, -178.86 in-na in 9.823 Saltbr-na 999.0 HRD-in -86.78, -65.09 96.66, -4.13 na-out-out SNCaoo out-out ActLoopNT-out 9.892 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.35, -36.77 APE9-dihe-out -64.06, -22.66 APE8-dihe-out -88.95, 4.87 APE8-rot-na 294.92 APE67-dihe-out -99.37, 27.39 -66.22, 138.89 APE12-dist-na 10.066 APE11-dist-na 11.654 APE10-dist-na 16.264 APE9-dist-out 12.825 W659A,W777A,F794H None None XRAY 1.9 0.162 0.201 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5ut5 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT6A O60674 537 808 1132.0 8MY:901 Type1 Pseudo DFGin 7.811 13.383 None -94.36, -179.3 -74.79, 159.2 -78.43, -9.68 26.67, 142.51 69.48, -170.15 in-na in 9.762 Saltbr-na 999.0 HRD-in -88.85, -58.65 93.81, -8.0 na-out-out SNCaoo out-out ActLoopNT-out 9.89 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.58, -38.89 APE9-dihe-out -63.87, -22.26 APE8-dihe-out -88.04, 3.04 APE8-rot-na 294.63 APE67-dihe-out -105.83, 26.71 -62.56, 137.4 APE12-dist-na 10.047 APE11-dist-na 11.672 APE10-dist-na 16.237 APE9-dist-out 13.024 W659A,W777A,F794H None None XRAY 1.645 0.169 0.206 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5ut6 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6BRWA O60674 537 808 1132.0 5BS:901 Type1 Pseudo DFGin 7.705 13.379 None -93.41, 174.89 -67.04, 156.04 -83.01, 0.59 33.82, 139.96 67.03, -167.12 in-na in 9.67 Saltbr-na 999.0 HRD-in -76.15, -62.39 95.18, -6.76 na-out-out SNCaoo out-out ActLoopNT-out 9.346 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -74.9, -35.05 APE9-dihe-out -58.77, -25.82 APE8-dihe-out -90.17, 2.34 APE8-rot-na 284.96 APE67-dihe-out -99.82, 21.48 -62.86, 134.79 APE12-dist-na 9.991 APE11-dist-na 11.563 APE10-dist-na 16.181 APE9-dist-out 12.811 W659A,W777A,F794H None None XRAY 2.031 0.197 0.25 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6brw TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6BS0A O60674 537 808 1132.0 E4V:901 Type1 Pseudo DFGin 7.08 13.256 None -88.58, 177.61 -73.17, 156.09 -79.5, -8.28 28.34, 142.63 71.71, -176.36 in-na in 9.568 Saltbr-na 999.0 HRD-in -86.4, -62.0 95.3, -5.83 na-out-out SNCaoo out-out ActLoopNT-out 9.904 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.75, -38.73 APE9-dihe-out -60.18, -24.31 APE8-dihe-out -91.13, 4.36 APE8-rot-na 292.13 APE67-dihe-out -103.61, 24.99 -63.19, 136.77 APE12-dist-na 10.05 APE11-dist-na 11.629 APE10-dist-na 16.231 APE9-dist-out 12.93 W659A,W777A,F794H None None XRAY 1.541 0.162 0.195 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6bs0 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6BSSA O60674 537 808 1132.0 4SP:902 Type1 Pseudo DFGin 7.568 13.511 None -92.12, 176.26 -71.33, 155.06 -76.95, -9.06 29.95, 143.27 73.96, -170.06 in-na in 9.688 Saltbr-na 999.0 HRD-in -85.06, -63.73 98.07, -5.96 na-out-out SNCaoo out-out ActLoopNT-out 9.888 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.01, -35.23 APE9-dihe-out -61.99, -26.69 APE8-dihe-out -86.73, 3.75 APE8-rot-na 289.32 APE67-dihe-out -100.38, 23.52 -64.28, 136.45 APE12-dist-na 9.985 APE11-dist-na 11.551 APE10-dist-na 16.187 APE9-dist-out 12.882 W659A,W777A,F794H None None XRAY 2.1 0.194 0.235 A 289 271 1 0 0 0 [[545, 807], [849, 1125]] 2.0 6bss TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6M9HA O60674 536 808 1132.0 J9D:901 Type1 Pseudo DFGin 7.866 13.199 None -93.81, -179.33 -75.36, 156.59 -79.44, -11.27 28.67, 140.35 75.69, -170.14 in-na in 9.789 Saltbr-na 999.0 HRD-in -82.1, -57.99 92.46, -9.79 na-out-out SNCaoo out-out ActLoopNT-out 9.792 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.63, -41.5 APE9-dihe-out -66.06, -19.63 APE8-dihe-out -87.45, 2.93 APE8-rot-na 291.17 APE67-dihe-out -101.95, 25.55 -63.43, 136.79 APE12-dist-na 10.049 APE11-dist-na 11.59 APE10-dist-na 16.207 APE9-dist-out 12.959 W659A,W777A,F794H None None XRAY 1.79 0.172 0.206 A 289 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6m9h TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OAVA O60674 537 808 1132.0 M3A:901 Type1 Pseudo DFGin 7.112 13.039 None -89.82, 175.57 -71.85, 155.92 -76.93, -12.28 28.1, 145.13 74.45, -170.6 in-na in 9.815 Saltbr-na 999.0 HRD-in -81.92, -60.26 97.52, -13.09 na-out-out SNCaoo out-out ActLoopNT-out 9.649 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.27, -33.28 APE9-dihe-out -70.41, -15.65 APE8-dihe-out -94.12, 2.48 APE8-rot-na 295.49 APE67-dihe-out -103.53, 27.01 -62.67, 134.47 APE12-dist-na 9.928 APE11-dist-na 11.491 APE10-dist-na 16.083 APE9-dist-out 12.706 W659A,W777A,F794H None None XRAY 1.939 0.202 0.236 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6oav TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OBBA O60674 537 808 1132.0 M3Y:901 Type1 Pseudo DFGin 7.342 13.234 None -84.34, 177.39 -74.24, 159.35 -79.81, -16.97 27.48, 144.61 78.13, -168.92 out-na out 10.134 Saltbr-na 999.0 HRD-in -82.45, -60.11 93.59, -13.21 na-out-out SNCaoo out-out ActLoopNT-out 9.734 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.05, -38.37 APE9-dihe-out -67.29, -18.2 APE8-dihe-out -91.42, 5.55 APE8-rot-na 289.4 APE67-dihe-out -101.89, 28.31 -66.13, 136.22 APE12-dist-na 9.976 APE11-dist-na 11.438 APE10-dist-na 16.1 APE9-dist-out 12.826 W659A,W777A,F794H None None XRAY 1.904 0.197 0.225 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6obb TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OBFA O60674 537 808 1132.0 M4G:902 Type1 Pseudo DFGin 5.802 13.575 None -75.4, 175.18 -69.61, 155.48 -61.14, -31.23 333.27, 38.74 78.42, -174.91 out-na out 11.73 Saltbr-na 999.0 HRD-in -79.03, -58.03 90.73, -7.36 na-out-out SNCaoo out-out ActLoopNT-out 9.126 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.35, -37.95 APE9-dihe-out -66.08, -20.0 APE8-dihe-out -89.74, 3.4 APE8-rot-na 287.78 APE67-dihe-out -103.65, 28.29 -65.52, 135.12 APE12-dist-na 9.876 APE11-dist-na 11.414 APE10-dist-na 16.018 APE9-dist-out 12.52 W659A,W777A,F794H None None XRAY 1.71 0.199 0.222 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6obf TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OBLA O60674 537 808 1132.0 M4P:901 Type1 Pseudo DFGin 6.131 13.618 None -84.06, 175.88 -72.71, 160.31 -68.63, -25.11 336.97, 36.63 73.61, -166.98 out-na out 11.6 Saltbr-na 999.0 HRD-in -78.47, -60.55 94.84, -3.9 na-out-out SNCaoo out-out ActLoopNT-out 9.075 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.59, -34.77 APE9-dihe-out -65.45, -25.46 APE8-dihe-out -86.12, 6.91 APE8-rot-na 289.77 APE67-dihe-out -101.28, 22.22 -64.94, 134.76 APE12-dist-na 9.865 APE11-dist-na 11.395 APE10-dist-na 16.044 APE9-dist-out 12.711 W659A,W777A,F794H None None XRAY 2.061 0.2 0.239 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6obl TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OCCA O60674 537 808 1132.0 M57:1002 Type1 Pseudo DFGin 6.062 13.569 None -84.33, 174.58 -71.42, 156.44 -66.05, -27.79 338.24, 34.72 78.91, -171.69 out-na out 11.717 Saltbr-na 999.0 HRD-in -79.87, -63.55 97.41, -5.73 na-out-out SNCaoo out-out ActLoopNT-out 9.26 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.17, -40.0 APE9-dihe-out -66.58, -22.02 APE8-dihe-out -86.2, 2.55 APE8-rot-na 295.02 APE67-dihe-out -102.04, 27.42 -65.31, 136.06 APE12-dist-na 9.937 APE11-dist-na 11.412 APE10-dist-na 16.0 APE9-dist-out 12.434 W659A,W777A,F794H None None XRAY 2.03 0.227 0.272 A 289 268 4 0 0 0 [[545, 807], [849, 1125]] 2.0 6occ TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6XJKA O60674 539 807 1132.0 V4D:901 Type1 Pseudo DFGin 7.086 13.11 None -82.39, -178.8 -73.6, 159.61 -82.47, -18.87 26.68, 148.75 79.98, -172.67 out-na out 10.943 Saltbr-na 999.0 HRD-in -78.39, -61.79 94.59, -5.62 na-out-out SNCaoo out-out ActLoopNT-out 9.177 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.63, -38.8 APE9-dihe-out -69.88, -19.28 APE8-dihe-out -90.06, 4.72 APE8-rot-na 291.97 APE67-dihe-out -100.24, 24.73 -62.96, 137.34 APE12-dist-na 9.833 APE11-dist-na 11.651 APE10-dist-na 16.135 APE9-dist-out 12.537 W659A,W777A,F794H None None XRAY 2.024 0.229 0.273 A 289 265 4 0 0 0 [[545, 807], [849, 1125]] 2.0 6xjk TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7JYOA O60674 539 808 1132.0 VPS:901 Type1 Pseudo DFGin 7.313 13.265 None -88.9, -179.5 -76.4, 155.67 -78.17, -11.76 25.61, 146.28 75.85, -168.38 in-na in 9.94 Saltbr-na 999.0 HRD-in -78.1, -62.53 100.04, -11.32 na-out-out SNCaoo out-out ActLoopNT-out 9.47 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.05, -35.44 APE9-dihe-out -67.28, -21.98 APE8-dihe-out -89.32, 5.73 APE8-rot-na 292.48 APE67-dihe-out -104.2, 24.04 -63.78, 134.25 APE12-dist-na 10.006 APE11-dist-na 11.495 APE10-dist-na 16.072 APE9-dist-out 12.671 W659A,W777A,F794H None None XRAY 2.161 0.188 0.246 A 289 270 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7jyo TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7JYQA O60674 537 808 1132.0 VPJ:902 Type1 Pseudo DFGin 7.645 13.005 None -92.98, -175.16 -77.54, 154.64 -78.8, -12.58 29.28, 143.4 74.39, -171.67 out-na out 13.073 Saltbr-na 999.0 HRD-in -86.04, -59.14 96.24, -12.09 na-out-out SNCaoo out-out ActLoopNT-out 9.812 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.31, -38.61 APE9-dihe-out -62.73, -23.3 APE8-dihe-out -89.27, 2.43 APE8-rot-na 292.66 APE67-dihe-out -102.33, 26.3 -62.62, 135.22 APE12-dist-na 10.015 APE11-dist-na 11.568 APE10-dist-na 16.168 APE9-dist-out 12.866 W659A,W777A,F794H None None XRAY 1.859 0.181 0.221 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7jyq TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7SZWA O60674 537 808 1132.0 DVY:901 Type1 Pseudo DFGin 6.452 13.26 None -82.57, 177.58 -73.21, 157.07 -69.74, -29.09 341.81, 33.15 77.93, -172.46 out-na out 12.306 Saltbr-na 999.0 HRD-in -80.57, -59.83 95.34, -11.68 na-out-out SNCaoo out-out ActLoopNT-out 9.255 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.83, -37.85 APE9-dihe-out -63.74, -25.15 APE8-dihe-out -91.51, 8.03 APE8-rot-na 297.58 APE67-dihe-out -99.24, 24.79 -65.54, 137.42 APE12-dist-na 9.926 APE11-dist-na 11.427 APE10-dist-na 16.064 APE9-dist-out 12.408 W659A,W777A,F794H None None XRAY 1.906 0.195 0.226 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7szw TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7T0PA O60674 536 808 1132.0 E3W:901 Type1 Pseudo DFGin 5.536 13.453 None -71.36, 169.62 -64.37, 154.19 -64.4, -34.91 335.03, 35.41 82.73, -164.25 out-na out 11.625 Saltbr-na 999.0 HRD-in -78.49, -60.16 92.47, -7.36 na-out-out SNCaoo out-out ActLoopNT-out 9.411 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.7, -41.68 APE9-dihe-out -61.62, -27.73 APE8-dihe-out -89.13, 13.42 APE8-rot-na 292.46 APE67-dihe-out -104.69, 27.09 -67.15, 136.9 APE12-dist-na 10.128 APE11-dist-na 11.477 APE10-dist-na 16.172 APE9-dist-out 12.825 W659A,W777A,F794H None None XRAY 2.04 0.197 0.247 A 289 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7t0p TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7T0PB O60674 536 808 1132.0 E3W:901 Type1 Pseudo DFGin 5.584 13.375 None -73.4, 171.14 -67.99, 156.9 -65.04, -35.98 333.3, 36.74 84.58, -160.86 out-na out 11.675 Saltbr-na 999.0 HRD-in -82.44, -59.87 91.7, -5.68 na-out-out SNCaoo out-out ActLoopNT-out 9.525 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.77, -34.38 APE9-dihe-out -70.23, -20.91 APE8-dihe-out -95.01, 13.79 APE8-rot-na 294.77 APE67-dihe-out -106.03, 28.99 -67.37, 133.92 APE12-dist-na 10.083 APE11-dist-na 11.624 APE10-dist-na 16.26 APE9-dist-out 12.957 W659A,W777A,F794H None None XRAY 2.04 0.197 0.247 B 289 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7t0p TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7T1TA O60674 536 809 1132.0 E8I:901 Type1 Pseudo DFGin 7.074 13.199 None -85.56, -179.34 -72.27, 154.59 -78.75, -8.81 22.02, 154.16 65.96, -165.49 out-na out 10.812 Saltbr-na 999.0 HRD-in -83.69, -59.16 91.95, -7.4 na-out-out SNCaoo out-out ActLoopNT-out 9.73 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.83, -40.65 APE9-dihe-out -65.84, -24.48 APE8-dihe-out -87.52, 8.41 APE8-rot-na 292.81 APE67-dihe-out -105.4, 28.45 -65.24, 133.84 APE12-dist-na 9.948 APE11-dist-na 11.612 APE10-dist-na 16.182 APE9-dist-out 12.938 W659A,W777A,F794H None None XRAY 2.08 0.183 0.228 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7t1t TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B9HA O60674 536 809 1132.0 Q7F:901 Type1 Pseudo DFGin 6.01 13.307 None -84.93, -177.89 -74.12, 157.3 -67.76, -31.57 343.4, 32.07 81.26, -168.8 out-na out 12.097 Saltbr-na 999.0 HRD-in -82.25, -60.3 91.76, -5.32 na-out-out SNCaoo out-out ActLoopNT-out 9.143 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.85, -39.85 APE9-dihe-out -62.27, -26.85 APE8-dihe-out -86.04, 1.76 APE8-rot-na 292.25 APE67-dihe-out -100.68, 23.58 -62.84, 136.16 APE12-dist-na 9.712 APE11-dist-na 11.434 APE10-dist-na 15.933 APE9-dist-out 12.428 W659A,W777A,F794H None None XRAY 1.5 0.182 0.208 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8b9h TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA3A O60674 536 812 1132.0 Q8U:60901 Type1 Pseudo DFGin 7.945 13.708 None -77.62, 172.89 -67.28, 156.81 -77.15, -9.78 24.71, 146.25 70.37, -168.01 out-na out 10.581 Saltbr-na 999.0 HRD-in -73.02, -63.41 91.28, -5.41 na-out-out SNCaoo out-out ActLoopNT-out 8.832 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.97, -37.88 APE9-dihe-out -69.87, -18.94 APE8-dihe-out -88.79, 5.92 APE8-rot-na 290.58 APE67-dihe-out -110.89, 28.54 -69.8, 129.69 APE12-dist-na 10.041 APE11-dist-na 11.89 APE10-dist-na 16.425 APE9-dist-out 12.509 W659A,W777A,F794H None None XRAY 1.4 0.175 0.197 A 289 277 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8ba3 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8EX0A O60674 536 808 1132.0 AQG:901 Type1 Pseudo DFGin 7.412 13.402 None -87.55, 174.91 -71.81, 159.18 -77.63, -11.45 24.29, 145.18 73.87, -172.91 in-na in 9.643 Saltbr-na 999.0 HRD-in -81.87, -61.41 94.19, -7.67 na-out-out SNCaoo out-out ActLoopNT-out 9.608 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.42, -37.24 APE9-dihe-out -64.33, -22.0 APE8-dihe-out -89.33, 0.5 APE8-rot-na 287.44 APE67-dihe-out -103.06, 26.06 -59.07, 135.76 APE12-dist-na 9.888 APE11-dist-na 11.561 APE10-dist-na 16.136 APE9-dist-out 12.686 W659A,W777A,F794H None None XRAY 1.85 0.179 0.228 A 289 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8ex0 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8EX1A O60674 537 808 1132.0 AD5:901 Type1 Pseudo DFGin 7.282 13.57 None -94.73, 174.88 -71.85, 156.73 -78.3, -7.64 23.96, 145.89 75.85, -176.26 in-na in 9.851 Saltbr-na 999.0 HRD-in -83.17, -61.66 95.43, -4.68 na-out-out SNCaoo out-out ActLoopNT-out 9.745 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.78, -38.61 APE9-dihe-out -63.17, -26.48 APE8-dihe-out -86.79, 6.17 APE8-rot-na 291.87 APE67-dihe-out -106.59, 26.74 -65.58, 134.04 APE12-dist-na 9.851 APE11-dist-na 11.55 APE10-dist-na 16.057 APE9-dist-out 12.773 W659A,W777A,F794H None None XRAY 1.5 0.169 0.191 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8ex1 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8EX2A O60674 536 808 1132.0 Q2Q:901 Type1 Pseudo DFGin 7.683 13.39 None -89.91, 173.83 -74.44, 158.35 -75.25, -10.25 27.64, 142.49 74.64, -169.3 in-na in 9.726 Saltbr-na 999.0 HRD-in -84.46, -65.65 96.23, -6.71 na-out-out SNCaoo out-out ActLoopNT-out 9.561 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.11, -41.46 APE9-dihe-out -59.07, -26.71 APE8-dihe-out -87.22, 3.02 APE8-rot-na 287.18 APE67-dihe-out -104.5, 26.8 -63.95, 134.55 APE12-dist-na 9.976 APE11-dist-na 11.51 APE10-dist-na 16.131 APE9-dist-out 12.634 W659A,W777A,F794H None None XRAY 1.9 0.172 0.203 A 289 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8ex2 TYR_JAK2-1_HUMAN TYR 2.7e-64 222.9 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 9ND5A O60674 536 809 1132.0 A1BXA:901 Type1 Pseudo DFGin 7.197 13.436 None -78.37, 174.28 -71.06, 155.85 -82.01, -13.03 28.16, 149.91 71.45, -157.96 out-na out 10.377 Saltbr-na 999.0 HRD-in -81.65, -70.18 103.7, -2.47 na-out-out SNCaoo out-out ActLoopNT-out 9.473 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -76.62, -29.08 APE9-dihe-out -76.41, -20.7 APE8-dihe-out -84.83, 10.94 APE8-rot-na 287.64 APE67-dihe-out -108.27, 36.81 -81.67, 130.11 APE12-dist-na 9.653 APE11-dist-na 11.441 APE10-dist-na 16.018 APE9-dist-out 12.453 None None None XRAY 2.4 0.214 0.278 A 280 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 9nd5 TYR_JAK2-1_HUMAN TYR 2.8e-64 222.8 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 9ND3A O60674 536 808 1132.0 A1BW6:901 Type1 Pseudo DFGin 5.996 13.116 None -64.1, 173.67 -70.95, 163.72 -78.01, -24.74 341.83, 32.74 77.82, -165.18 out-na out 11.374 Saltbr-na 999.0 HRD-in -84.19, -60.63 89.29, -1.33 na-out-out SNCaoo out-out ActLoopNT-out 9.195 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.37, -39.11 APE9-dihe-out -58.8, -29.7 APE8-dihe-out -87.32, 4.81 APE8-rot-na 289.91 APE67-dihe-out -104.68, 28.28 -65.86, 133.14 APE12-dist-na 9.657 APE11-dist-na 11.461 APE10-dist-na 16.002 APE9-dist-out 12.276 None None None XRAY 1.62 0.189 0.22 A 283 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 9nd3 TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR PTK7 PTK7_HUMAN 6VG3A Q13308 788 1064 1070.0 No_ligand No_ligand Pseudo DFGout 13.072 8.61 BBAminus -132.34, -161.44 -155.86, 92.46 -97.69, -48.83 283.16, 84.9 56.84, 47.43 in-in in 7.577 Saltbr-in 2.798 HRD-in -72.42, -53.38 81.44, -12.12 in-out-in SNCioi out-in ActLoopNT-out 19.184 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.31, 104.46 APE9-dihe-in -109.64, 148.6 APE8-dihe-in -79.12, 64.71 APE8-rot-na 28.7 APE67-dihe-in -66.82, -5.68 -34.68, -60.13 APE12-dist-na 18.612 APE11-dist-na 14.329 APE10-dist-na 9.652 APE9-dist-in 7.427 None None None XRAY 1.95 0.192 0.244 A 296 277 0 0 0 0 [[796, 1063]] 1.0 6vg3 TYR_PTK7_HUMAN TYR 8.5e-87 296.7 4 259 256 947 948 949 951 953 830 846 850 927 929 928 930 988 976 971 970 969 968 967 966 965 876 Inactive tyrosine-protein kinase 7
TYR PTK7 PTK7_HUMAN 6VG3B Q13308 788 1066 1070.0 No_ligand No_ligand Pseudo DFGout 13.088 8.38 BBAminus -131.68, -160.87 -157.21, 94.94 -101.44, -43.98 278.12, 86.39 51.45, 55.01 in-in in 7.598 Saltbr-in 2.688 HRD-in -63.01, -52.6 78.41, -7.98 in-out-in SNCioi out-in ActLoopNT-out 19.006 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.07, 113.56 APE9-dihe-in -113.29, 141.65 APE8-dihe-in -78.24, 63.62 APE8-rot-na 29.31 APE67-dihe-in -67.88, -8.76 -38.92, -54.25 APE12-dist-na 17.367 APE11-dist-na 13.49 APE10-dist-na 8.814 APE9-dist-in 7.315 None None None XRAY 1.95 0.192 0.244 B 296 279 0 0 0 0 [[796, 1063]] 1.0 6vg3 TYR_PTK7_HUMAN TYR 8.5e-87 296.7 4 259 256 947 948 949 951 953 830 846 850 927 929 928 930 988 976 971 970 969 968 967 966 965 876 Inactive tyrosine-protein kinase 7
TYR PTK7 PTK7_HUMAN 6VG3C Q13308 789 1063 1070.0 No_ligand No_ligand Pseudo DFGout 13.009 8.498 BBAminus -129.46, -163.85 -155.05, 92.33 -97.04, -44.83 285.72, 96.38 51.74, 52.51 in-in in 7.676 Saltbr-in 2.685 HRD-in -64.52, -54.07 79.6, -11.28 in-out-in SNCioi out-in ActLoopNT-out 18.772 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.66, 107.88 APE9-dihe-in -124.36, 144.24 APE8-dihe-in -79.62, 62.86 APE8-rot-na 27.94 APE67-dihe-in -70.37, -4.0 -30.14, -56.43 APE12-dist-na 18.544 APE11-dist-na 15.16 APE10-dist-na 9.995 APE9-dist-in 7.27 None None None XRAY 1.95 0.192 0.244 C 296 265 10 0 0 0 [[796, 1063]] 1.0 6vg3 TYR_PTK7_HUMAN TYR 8.5e-87 296.7 4 259 256 947 948 949 951 953 830 846 850 927 929 928 930 988 976 971 970 969 968 967 966 965 876 Inactive tyrosine-protein kinase 7
TYR ROR1 ROR1_HUMAN 6TU9A Q01973 460 749 937.0 0LI:801 Type1 Pseudo None 999.0 999.0 None -143.45, 175.76 -148.29, 81.04 -104.43, 119.64 999.0, 999.0 -53.65, -7.79 in-in in 8.227 Saltbr-in 2.725 HRD-in -69.35, -57.72 81.6, -11.35 in-out-in SNCioi out-in ActLoopNT-out 15.395 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -88.59, 129.49 APE9-dihe-in -125.15, 133.19 APE8-dihe-in -78.4, 68.8 APE8-rot-na 36.93 APE67-dihe-in -68.17, -18.18 -55.42, -35.07 APE12-dist-na 999.0 APE11-dist-na 15.69 APE10-dist-na 11.605 APE9-dist-in 6.992 None None None XRAY 1.94 0.21 0.241 A 306 268 22 0 0 4 [[473, 748]] 1.0 6tu9 TYR_ROR1_HUMAN TYR 1.2e-94 322.4 2 260 259 632 633 634 636 638 506 523 527 612 614 613 615 674 662 657 656 655 654 653 652 651 553 Inactive tyrosine-protein kinase transmembrane receptor ROR1
TYR ROR1 ROR1_HUMAN 6TU9B Q01973 465 750 937.0 0LI:801 Type1 Pseudo None 999.0 999.0 None -143.03, 176.7 -144.7, 81.77 -85.65, -31.03 999.0, 999.0 92.49, -44.82 in-in in 8.283 Saltbr-in 2.974 HRD-in -64.86, -61.91 82.91, -9.99 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.96, 129.63 APE9-dihe-in -119.15, 127.45 APE8-dihe-in -76.72, 68.52 APE8-rot-na 33.66 APE67-dihe-in -67.05, -20.69 -57.04, -32.64 APE12-dist-na 17.025 APE11-dist-na 15.144 APE10-dist-na 11.197 APE9-dist-in 6.97 None None None XRAY 1.94 0.21 0.241 B 306 261 25 0 0 2 [[473, 748]] 1.0 6tu9 TYR_ROR1_HUMAN TYR 1.2e-94 322.4 2 260 259 632 633 634 636 638 506 523 527 612 614 613 615 674 662 657 656 655 654 653 652 651 553 Inactive tyrosine-protein kinase transmembrane receptor ROR1
TYR ROR2 ROR2_HUMAN 3ZZWA Q01974 466 750 943.0 No_ligand No_ligand Pseudo DFGinter 10.345 8.07 None -96.3, 113.42 -93.32, 36.02 -147.08, 160.59 50.4, 103.61 174.45, -162.31 in-out in 8.469 Saltbr-out 4.596 HRD-in -47.14, -51.88 77.11, -23.02 out-out-in SNCooi out-in ActLoopNT-out 17.444 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.81, 114.23 APE9-dihe-in -109.27, 120.13 APE8-dihe-in -82.4, 68.78 APE8-rot-na 28.79 APE67-dihe-in -64.86, -16.77 -44.26, -50.32 APE12-dist-na 13.627 APE11-dist-na 12.242 APE10-dist-na 7.628 APE9-dist-in 7.665 None None None XRAY 2.9 0.19 0.247 A 289 269 16 0 0 0 [[473, 748]] 1.0 3zzw TYR_ROR2_HUMAN TYR 5.3e-91 310.4 2 260 259 632 633 634 636 638 507 524 528 612 614 613 615 674 662 657 656 655 654 653 652 651 554 Tyrosine-protein kinase transmembrane receptor ROR2
TYR ROR2 ROR2_HUMAN 4GT4A Q01974 464 751 943.0 No_ligand No_ligand Pseudo DFGinter 9.614 6.483 None -93.67, 118.8 -119.64, 62.63 -106.27, -3.3 278.25, 67.29 61.48, 39.98 in-out in 8.533 Saltbr-out 3.871 HRD-out -75.16, 142.52 -112.65, 2.81 out-out-in SNCooi out-in ActLoopNT-out 16.314 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.46, 127.32 APE9-dihe-in -119.05, 136.77 APE8-dihe-in -80.2, 67.59 APE8-rot-na 30.63 APE67-dihe-in -67.7, -19.84 -54.55, -34.96 APE12-dist-na 15.894 APE11-dist-na 12.718 APE10-dist-na 10.239 APE9-dist-in 6.747 None None None XRAY 2.406 0.179 0.205 A 308 274 14 0 0 0 [[473, 748]] 1.0 4gt4 TYR_ROR2_HUMAN TYR 6.7e-91 310.1 2 260 259 632 633 634 636 638 507 524 528 612 614 613 615 674 662 657 656 655 654 653 652 651 554 Tyrosine-protein kinase transmembrane receptor ROR2
TYR ROR2 ROR2_HUMAN 4GT4B Q01974 464 752 943.0 No_ligand No_ligand Pseudo DFGinter 10.193 7.582 None -91.01, 100.94 -99.91, 70.26 -110.46, -11.91 297.81, 174.51 61.14, 43.64 in-in in 8.881 Saltbr-in 2.975 HRD-in -71.57, -49.3 78.13, -12.79 in-out-in SNCioi out-in ActLoopNT-out 16.141 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.88, 120.55 APE9-dihe-in -112.46, 137.59 APE8-dihe-in -79.18, 69.28 APE8-rot-na 29.96 APE67-dihe-in -69.15, -20.22 -53.97, -34.39 APE12-dist-na 15.711 APE11-dist-na 12.448 APE10-dist-na 10.062 APE9-dist-in 6.755 None None None XRAY 2.406 0.179 0.205 B 308 273 16 0 0 0 [[473, 748]] 1.0 4gt4 TYR_ROR2_HUMAN TYR 6.7e-91 310.1 2 260 259 632 633 634 636 638 507 524 528 612 614 613 615 674 662 657 656 655 654 653 652 651 554 Tyrosine-protein kinase transmembrane receptor ROR2
TYR ROR2 ROR2_HUMAN 3ZZWB Q01974 466 750 943.0 No_ligand No_ligand Pseudo DFGout 16.98 12.863 None -137.59, -157.96 -151.06, 33.97 -68.88, -19.62 62.12, 76.59 -42.22, -63.32 in-out in 8.671 Saltbr-out 5.013 HRD-in -47.64, -52.27 76.28, -20.82 out-out-in SNCooi out-in ActLoopNT-out 17.908 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.84, 114.99 APE9-dihe-in -110.43, 119.46 APE8-dihe-in -82.84, 69.13 APE8-rot-na 28.38 APE67-dihe-in -65.02, -16.31 -43.72, -51.28 APE12-dist-na 13.216 APE11-dist-na 11.513 APE10-dist-na 6.081 APE9-dist-in 7.603 None None None XRAY 2.9 0.19 0.247 B 289 265 20 0 0 0 [[473, 748]] 1.0 3zzw TYR_ROR2_HUMAN TYR 5.3e-91 310.4 2 260 259 632 633 634 636 638 507 524 528 612 614 613 615 674 662 657 656 655 654 653 652 651 554 Tyrosine-protein kinase transmembrane receptor ROR2
TYR TYK2-12 TYK2_HUMAN 4OLIA P29597 579 1177 1187.0 2TT:1201,2TT:1202 Allosteric,Type1 Pseudo DFGin 6.584 14.06 BLAminus -112.91, -164.12 51.99, 82.7 -97.25, 13.35 286.86, 70.8 -52.39, -43.72 in-in in 7.973 Saltbr-in 3.587 HRD-in -83.85, -51.17 64.18, 9.79 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.93, 161.16 APE9-dihe-in -150.27, 143.84 APE8-dihe-in -73.85, 77.54 APE8-rot-na 27.48 APE67-dihe-in -66.57, -4.05 -49.5, -43.89 APE12-dist-na 11.713 APE11-dist-na 9.483 APE10-dist-na 10.323 APE9-dist-in 6.04 D1023N None None XRAY 2.8 0.205 0.257 A 645 539 60 0 0 0 [[589, 868], [897, 1171]] 2.0 4oli TYR_TYK2-12_HUMAN TYR 4.2e-59 483.0 2 260 518 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5C03A P29597 579 869 1187.0 AGS:901 ATPlike Pseudo DFGin 7.384 13.105 None -83.93, 173.19 -65.21, 161.12 -79.17, -4.85 20.2, 153.73 66.68, -148.85 in-na in 9.794 Saltbr-na 999.0 HRD-in -90.34, -65.69 85.25, 3.79 na-out-out SNCaoo out-out ActLoopNT-out 7.833 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.44, -38.84 APE9-dihe-out -63.06, -21.54 APE8-dihe-out -87.7, -1.06 APE8-rot-na 196.81 APE67-dihe-out -97.84, 8.94 -69.26, 133.75 APE12-dist-na 10.117 APE11-dist-na 12.251 APE10-dist-na 16.457 APE9-dist-out 11.202 None None None XRAY 1.9 0.183 0.218 A 342 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 5c03 TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5C03B P29597 580 870 1187.0 AGS:901 ATPlike Pseudo DFGin 7.517 12.886 None -71.74, 164.11 -66.43, 161.04 -81.86, 0.59 24.73, 148.49 67.14, -147.92 in-na in 9.709 Saltbr-na 999.0 HRD-in -90.78, -63.58 88.98, 2.52 na-out-out SNCaoo out-out ActLoopNT-out 7.957 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.24, -42.55 APE9-dihe-out -56.38, -27.94 APE8-dihe-out -85.13, -4.16 APE8-rot-na 194.3 APE67-dihe-out -97.21, 10.32 -66.64, 134.88 APE12-dist-na 9.635 APE11-dist-na 12.304 APE10-dist-na 16.484 APE9-dist-out 11.221 None None None XRAY 1.9 0.183 0.218 B 342 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 5c03 TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7AX4A P29597 579 868 1187.0 NM7:2000 Type1 Pseudo DFGin 7.507 12.805 None -76.81, 166.44 -58.43, 152.23 -70.05, -8.8 24.77, 146.14 76.34, -154.15 in-na in 9.556 Saltbr-na 999.0 HRD-in -86.69, -61.89 82.12, 4.68 na-out-out SNCaoo out-out ActLoopNT-out 8.232 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.65, -45.17 APE9-dihe-out -58.59, -27.02 APE8-dihe-out -78.56, -9.63 APE8-rot-na 222.71 APE67-dihe-out -95.98, 6.87 -68.07, 131.63 APE12-dist-na 9.662 APE11-dist-na 12.284 APE10-dist-na 16.464 APE9-dist-out 11.658 None None None XRAY 2.12 0.186 0.229 A 295 261 29 0 0 0 [[589, 868], [897, 1171]] 2.0 7ax4 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7AX4B P29597 579 868 1187.0 NM7:2000 Type1 Pseudo DFGin 7.488 12.776 None -74.88, 165.0 -57.44, 152.12 -71.28, -8.27 25.03, 145.7 75.91, -154.77 in-na in 9.496 Saltbr-na 999.0 HRD-in -85.26, -61.54 83.16, 3.63 na-out-out SNCaoo out-out ActLoopNT-out 8.325 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.51, -41.43 APE9-dihe-out -63.74, -26.18 APE8-dihe-out -77.76, -6.82 APE8-rot-na 221.04 APE67-dihe-out -90.97, 8.23 -71.21, 136.1 APE12-dist-na 9.807 APE11-dist-na 12.32 APE10-dist-na 16.542 APE9-dist-out 11.793 None None None XRAY 2.12 0.186 0.229 B 295 261 29 0 0 0 [[589, 868], [897, 1171]] 2.0 7ax4 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98A P29597 578 867 1187.0 ZRU:901 Type1 Pseudo DFGin 7.353 12.698 None -63.41, 150.46 -40.02, 136.95 -69.11, -5.37 28.88, 139.25 79.24, -154.61 in-na in 9.676 Saltbr-na 999.0 HRD-in -86.71, -58.07 85.92, 3.99 na-out-out SNCaoo out-out ActLoopNT-out 8.115 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.34, -41.36 APE9-dihe-out -63.27, -26.83 APE8-dihe-out -87.06, 1.76 APE8-rot-na 289.42 APE67-dihe-out -101.27, 10.15 -70.05, 135.5 APE12-dist-na 9.77 APE11-dist-na 12.368 APE10-dist-na 16.501 APE9-dist-out 11.633 None None CSO808 XRAY 1.87 0.226 0.274 A 295 256 35 0 0 0 [[589, 868], [897, 1171]] 2.0 8s98 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98B P29597 578 867 1187.0 ZRU:901 Type1 Pseudo DFGin 7.339 12.942 None -54.77, 156.29 -53.9, 146.74 -74.48, -2.14 30.11, 138.2 66.75, -149.92 in-na in 9.696 Saltbr-na 999.0 HRD-in -77.0, -58.39 85.56, 3.19 na-out-out SNCaoo out-out ActLoopNT-out 8.466 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.92, -37.3 APE9-dihe-out -60.59, -30.35 APE8-dihe-out -84.45, -1.45 APE8-rot-na 293.47 APE67-dihe-out -99.24, 10.29 -63.77, 131.59 APE12-dist-na 9.967 APE11-dist-na 12.261 APE10-dist-na 16.539 APE9-dist-out 11.738 None None CSO808 XRAY 1.87 0.226 0.274 B 295 259 32 0 0 0 [[589, 868], [897, 1171]] 2.0 8s98 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98C P29597 578 868 1187.0 ZRU:901 Type1 Pseudo DFGin 7.558 12.819 None -59.14, 154.57 -51.18, 142.9 -77.73, 6.11 31.51, 139.73 67.49, -158.75 in-na in 9.615 Saltbr-na 999.0 HRD-in -81.52, -60.95 90.44, 9.6 na-out-out SNCaoo out-out ActLoopNT-out 8.572 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.87, -38.56 APE9-dihe-out -63.68, -27.1 APE8-dihe-out -84.04, -1.3 APE8-rot-na 288.57 APE67-dihe-out -98.82, 11.75 -65.96, 135.63 APE12-dist-na 9.932 APE11-dist-na 12.277 APE10-dist-na 16.512 APE9-dist-out 11.862 None None CSO808 XRAY 1.87 0.226 0.274 C 295 261 30 0 0 0 [[589, 868], [897, 1171]] 2.0 8s98 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S99A P29597 578 868 1187.0 ZS3:901 Type1 Pseudo DFGin 7.399 12.782 None -62.82, 155.3 -51.38, 147.9 -74.24, -0.55 28.63, 142.53 65.17, -151.12 in-na in 9.659 Saltbr-na 999.0 HRD-in -82.17, -60.98 83.64, 7.23 na-out-out SNCaoo out-out ActLoopNT-out 8.33 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.74, -38.21 APE9-dihe-out -59.13, -29.8 APE8-dihe-out -88.76, 1.4 APE8-rot-na 298.32 APE67-dihe-out -97.29, 12.8 -68.06, 135.28 APE12-dist-na 9.928 APE11-dist-na 12.29 APE10-dist-na 16.586 APE9-dist-out 11.761 None None None XRAY 1.71 0.191 0.225 A 295 261 30 0 0 0 [[589, 868], [897, 1171]] 2.0 8s99 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S99B P29597 579 867 1187.0 ZS3:901 Type1 Pseudo DFGin 7.443 12.614 None -56.5, 153.96 -51.89, 147.7 -74.35, -1.31 29.46, 140.64 65.58, -151.37 in-na in 9.557 Saltbr-na 999.0 HRD-in -80.48, -58.61 84.39, 4.19 na-out-out SNCaoo out-out ActLoopNT-out 8.426 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.04, -40.63 APE9-dihe-out -58.98, -25.02 APE8-dihe-out -89.21, 1.32 APE8-rot-na 294.34 APE67-dihe-out -101.31, 17.67 -66.15, 136.61 APE12-dist-na 9.909 APE11-dist-na 12.186 APE10-dist-na 16.471 APE9-dist-out 11.849 None None None XRAY 1.71 0.191 0.225 B 295 261 29 0 0 0 [[589, 868], [897, 1171]] 2.0 8s99 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S99C P29597 578 867 1187.0 ZS3:901 Type1 Pseudo DFGin 7.462 12.589 None -61.71, 157.01 -52.78, 147.81 -73.85, -0.24 30.37, 137.25 70.68, -153.5 in-na in 9.588 Saltbr-na 999.0 HRD-in -82.08, -63.18 88.21, 6.86 na-out-out SNCaoo out-out ActLoopNT-out 8.173 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.66, -43.16 APE9-dihe-out -54.27, -29.75 APE8-dihe-out -91.84, 3.24 APE8-rot-na 295.26 APE67-dihe-out -102.57, 13.29 -66.4, 134.15 APE12-dist-na 9.738 APE11-dist-na 12.432 APE10-dist-na 16.544 APE9-dist-out 11.684 None None None XRAY 1.71 0.191 0.225 C 295 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 8s99 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AA P29597 577 868 1187.0 ZSB:901 Type1 Pseudo DFGin 7.465 12.783 None -59.49, 156.87 -53.44, 145.49 -73.94, -3.93 28.08, 142.08 71.29, -152.49 in-na in 9.645 Saltbr-na 999.0 HRD-in -80.97, -57.69 81.03, 6.24 na-out-out SNCaoo out-out ActLoopNT-out 8.468 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.12, -39.62 APE9-dihe-out -57.45, -31.53 APE8-dihe-out -85.9, -0.44 APE8-rot-na 294.43 APE67-dihe-out -98.22, 12.4 -65.02, 133.34 APE12-dist-na 9.967 APE11-dist-na 12.285 APE10-dist-na 16.605 APE9-dist-out 11.838 None None None XRAY 1.83 0.186 0.224 A 295 264 28 0 0 0 [[589, 868], [897, 1171]] 2.0 8s9a TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AB P29597 578 867 1187.0 ZSB:901 Type1 Pseudo DFGin 7.549 12.607 None -55.02, 155.39 -55.48, 149.15 -78.11, 1.0 33.17, 138.7 68.16, -152.66 in-na in 9.568 Saltbr-na 999.0 HRD-in -83.23, -60.75 91.28, -0.48 na-out-out SNCaoo out-out ActLoopNT-out 8.591 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.5, -42.74 APE9-dihe-out -57.15, -27.18 APE8-dihe-out -83.95, -1.9 APE8-rot-na 289.14 APE67-dihe-out -98.17, 15.26 -66.86, 137.45 APE12-dist-na 9.96 APE11-dist-na 12.078 APE10-dist-na 16.412 APE9-dist-out 11.895 None None None XRAY 1.83 0.186 0.224 B 295 263 28 0 0 0 [[589, 868], [897, 1171]] 2.0 8s9a TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AC P29597 578 867 1187.0 ZSB:901 Type1 Pseudo DFGin 7.452 12.668 None -61.15, 155.8 -50.19, 148.71 -74.89, -0.44 30.12, 140.82 66.87, -150.05 in-na in 9.655 Saltbr-na 999.0 HRD-in -81.68, -62.05 88.29, 3.19 na-out-out SNCaoo out-out ActLoopNT-out 8.26 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.23, -43.49 APE9-dihe-out -60.0, -25.56 APE8-dihe-out -89.19, -0.15 APE8-rot-na 289.26 APE67-dihe-out -98.71, 15.21 -67.33, 135.82 APE12-dist-na 9.697 APE11-dist-na 12.309 APE10-dist-na 16.494 APE9-dist-out 11.766 None None None XRAY 1.83 0.186 0.224 C 295 261 30 0 0 0 [[589, 868], [897, 1171]] 2.0 8s9a TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5TKDA P29597 581 866 1187.0 7GL:901 Type1 Pseudo DFGin 7.513 12.63 None -67.32, 165.44 -61.21, 150.11 -77.85, 2.5 30.62, 144.39 70.23, -152.17 in-na in 9.487 Saltbr-na 999.0 HRD-in -86.12, -60.06 82.4, 7.11 na-out-out SNCaoo out-out ActLoopNT-out 8.163 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.41, -39.74 APE9-dihe-out -61.67, -21.18 APE8-dihe-out -86.78, -7.05 APE8-rot-na 289.65 APE67-dihe-out -93.06, 5.59 -69.25, 133.26 APE12-dist-na 9.69 APE11-dist-na 12.22 APE10-dist-na 16.406 APE9-dist-out 11.578 None None None XRAY 1.92 0.193 0.215 A 298 248 40 0 0 0 [[589, 868], [897, 1171]] 2.0 5tkd TYR_TYK2-1_HUMAN TYR 4.2e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5TKDB P29597 581 867 1187.0 7GL:901 Type1 Pseudo DFGin 7.534 12.489 None -66.93, 165.19 -61.5, 149.63 -77.96, 1.32 30.48, 144.44 72.41, -154.16 in-na in 9.422 Saltbr-na 999.0 HRD-in -86.72, -59.64 79.99, 10.31 na-out-out SNCaoo out-out ActLoopNT-out 8.029 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.45, -40.77 APE9-dihe-out -60.64, -23.02 APE8-dihe-out -86.44, -3.61 APE8-rot-na 200.95 APE67-dihe-out -92.39, 6.26 -73.47, 133.63 APE12-dist-na 9.666 APE11-dist-na 12.184 APE10-dist-na 16.381 APE9-dist-out 11.457 None None None XRAY 1.92 0.193 0.215 B 298 247 41 0 0 0 [[589, 868], [897, 1171]] 2.0 5tkd TYR_TYK2-1_HUMAN TYR 4.2e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 3ZONA P29597 577 870 1187.0 IK1:1871 Type1 Pseudo DFGin 7.368 12.762 None -83.03, 173.2 -63.77, 153.55 -76.54, -5.77 26.47, 146.49 67.78, -154.99 in-na in 9.655 Saltbr-na 999.0 HRD-in -77.23, -57.87 87.41, -1.46 na-out-out SNCaoo out-out ActLoopNT-out 8.36 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.01, -48.69 APE9-dihe-out -50.14, -31.16 APE8-dihe-out -81.83, -2.56 APE8-rot-na 292.76 APE67-dihe-out -91.8, 2.07 -66.27, 133.13 APE12-dist-na 10.153 APE11-dist-na 12.31 APE10-dist-na 16.62 APE9-dist-out 11.977 None None None XRAY 2.15 0.217 0.268 A 335 261 33 0 0 0 [[589, 868], [897, 1171]] 2.0 3zon TYR_TYK2-1_HUMAN TYR 6.5e-60 208.7 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZRA P29597 578 867 1187.0 LAJ:901 Type1 Pseudo DFGin 7.777 12.781 None -69.45, 168.07 -65.99, 154.27 -73.6, -4.41 23.84, 151.16 77.17, -140.45 in-na in 9.435 Saltbr-na 999.0 HRD-in -82.75, -62.0 89.42, -4.52 na-out-out SNCaoo out-out ActLoopNT-out 8.095 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.36, -40.74 APE9-dihe-out -63.5, -26.3 APE8-dihe-out -83.27, -1.28 APE8-rot-na 205.99 APE67-dihe-out -86.49, -0.68 -74.39, 134.15 APE12-dist-na 9.712 APE11-dist-na 12.195 APE10-dist-na 16.359 APE9-dist-out 11.553 None None None XRAY 2.56 0.19 0.229 A 317 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzr TYR_TYK2-1_HUMAN TYR 3e-60 209.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZRB P29597 580 868 1187.0 LAJ:901 Type1 Pseudo DFGin 7.794 12.735 None -69.51, 167.49 -66.18, 155.4 -74.3, -4.56 23.99, 151.21 77.6, -139.58 in-na in 9.371 Saltbr-na 999.0 HRD-in -85.74, -61.72 89.77, -6.44 na-out-out SNCaoo out-out ActLoopNT-out 8.164 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.72, -41.32 APE9-dihe-out -63.03, -22.95 APE8-dihe-out -84.92, -4.81 APE8-rot-na 227.24 APE67-dihe-out -86.54, 0.37 -71.84, 134.55 APE12-dist-na 9.706 APE11-dist-na 12.223 APE10-dist-na 16.378 APE9-dist-out 11.55 None None None XRAY 2.56 0.19 0.229 B 317 259 30 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzr TYR_TYK2-1_HUMAN TYR 3e-60 209.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 4WOVA P29597 580 869 1187.0 3SM:901 Type1 Pseudo DFGin 7.414 12.612 None -81.79, 172.74 -64.96, 152.2 -79.14, 3.8 29.41, 144.45 64.39, -148.74 in-na in 9.434 Saltbr-na 999.0 HRD-in -91.37, -57.71 81.66, 1.38 na-out-out SNCaoo out-out ActLoopNT-out 8.472 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.89, -40.33 APE9-dihe-out -59.96, -25.88 APE8-dihe-out -82.28, -6.26 APE8-rot-na 203.31 APE67-dihe-out -93.77, 1.64 -65.5, 131.41 APE12-dist-na 9.865 APE11-dist-na 12.155 APE10-dist-na 16.373 APE9-dist-out 11.62 None None None XRAY 1.8 0.193 0.214 A 317 258 32 0 0 0 [[589, 868], [897, 1171]] 2.0 4wov TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 4WOVB P29597 580 867 1187.0 3SM:901 Type1 Pseudo DFGin 7.375 12.564 None -82.96, 174.29 -64.97, 150.22 -78.54, 4.38 29.82, 144.02 64.16, -150.45 in-na in 9.386 Saltbr-na 999.0 HRD-in -91.0, -57.11 81.71, 1.86 na-out-out SNCaoo out-out ActLoopNT-out 8.54 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.69, -39.07 APE9-dihe-out -62.22, -22.21 APE8-dihe-out -86.45, -3.31 APE8-rot-na 190.55 APE67-dihe-out -96.7, 6.38 -71.04, 134.12 APE12-dist-na 9.828 APE11-dist-na 12.112 APE10-dist-na 16.313 APE9-dist-out 11.656 None None None XRAY 1.8 0.193 0.214 B 317 256 33 0 0 0 [[589, 868], [897, 1171]] 2.0 4wov TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NSLA P29597 581 866 1187.0 KZJ:901 Type1 Pseudo DFGin 7.447 12.627 None -65.67, 163.1 -59.9, 147.3 -72.43, 0.95 25.4, 149.24 71.0, -150.31 in-na in 9.45 Saltbr-na 999.0 HRD-in -79.19, -61.15 86.61, -0.76 na-out-out SNCaoo out-out ActLoopNT-out 8.317 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.34, -39.28 APE9-dihe-out -63.02, -22.39 APE8-dihe-out -82.22, -10.35 APE8-rot-na 292.93 APE67-dihe-out -91.53, -2.04 -67.32, 133.05 APE12-dist-na 9.722 APE11-dist-na 12.197 APE10-dist-na 16.413 APE9-dist-out 11.7 None None None XRAY 2.15 0.203 0.213 A 317 251 37 0 0 0 [[589, 868], [897, 1171]] 2.0 6nsl TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NSLB P29597 581 867 1187.0 KZJ:901 Type1 Pseudo DFGin 7.466 12.543 None -65.53, 162.68 -58.2, 146.74 -72.38, 1.37 25.74, 148.82 71.06, -152.3 in-na in 9.423 Saltbr-na 999.0 HRD-in -80.39, -61.97 87.32, -2.61 na-out-out SNCaoo out-out ActLoopNT-out 8.241 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.57, -38.38 APE9-dihe-out -63.64, -23.52 APE8-dihe-out -84.88, -4.11 APE8-rot-na 200.51 APE67-dihe-out -91.36, -1.36 -71.83, 133.14 APE12-dist-na 9.667 APE11-dist-na 12.177 APE10-dist-na 16.391 APE9-dist-out 11.568 None None None XRAY 2.15 0.203 0.213 B 317 248 40 0 0 0 [[589, 868], [897, 1171]] 2.0 6nsl TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZEA P29597 581 863 1187.0 L8Y:901 Type1 Pseudo DFGin 7.517 12.327 None -67.15, 165.53 -62.27, 154.27 -78.2, -0.61 28.22, 144.21 70.11, -150.04 in-na in 9.308 Saltbr-na 999.0 HRD-in -90.68, -61.1 81.57, 5.39 na-out-out SNCaoo out-out ActLoopNT-out 8.127 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.25, -36.4 APE9-dihe-out -64.18, -24.4 APE8-dihe-out -85.3, -4.22 APE8-rot-na 196.84 APE67-dihe-out -93.12, 7.25 -69.65, 135.35 APE12-dist-na 9.814 APE11-dist-na 12.241 APE10-dist-na 16.458 APE9-dist-out 11.439 None None None XRAY 1.96 0.197 0.227 A 317 250 38 0 0 0 [[589, 868], [897, 1171]] 2.0 6nze TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZEB P29597 580 867 1187.0 L8Y:901 Type1 Pseudo DFGin 7.51 12.331 None -67.31, 165.25 -60.76, 154.35 -79.17, -0.55 28.55, 143.7 69.96, -145.72 in-na in 9.336 Saltbr-na 999.0 HRD-in -88.53, -60.87 81.08, 6.03 na-out-out SNCaoo out-out ActLoopNT-out 8.073 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.94, -35.62 APE9-dihe-out -64.8, -24.24 APE8-dihe-out -85.49, -3.91 APE8-rot-na 196.79 APE67-dihe-out -92.3, 6.8 -70.0, 135.83 APE12-dist-na 9.732 APE11-dist-na 12.151 APE10-dist-na 16.38 APE9-dist-out 11.416 None None None XRAY 1.96 0.197 0.227 B 317 254 35 0 0 0 [[589, 868], [897, 1171]] 2.0 6nze TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZFA P29597 580 865 1187.0 L91:901 Type1 Pseudo DFGin 7.6 12.671 None -71.29, 168.26 -64.87, 155.03 -75.86, -3.47 25.03, 153.09 77.38, -149.91 in-na in 9.401 Saltbr-na 999.0 HRD-in -80.34, -62.67 82.96, 5.24 na-out-out SNCaoo out-out ActLoopNT-out 8.094 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.48, -39.01 APE9-dihe-out -62.83, -25.44 APE8-dihe-out -82.23, -7.85 APE8-rot-na 215.68 APE67-dihe-out -92.43, 5.04 -68.27, 132.64 APE12-dist-na 9.808 APE11-dist-na 12.262 APE10-dist-na 16.517 APE9-dist-out 11.623 None None None XRAY 2.39 0.205 0.231 A 317 247 42 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzf TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZFB P29597 580 867 1187.0 L91:901 Type1 Pseudo DFGin 7.67 12.598 None -70.84, 168.4 -64.97, 153.82 -75.67, -2.7 25.33, 152.34 77.04, -149.81 in-na in 9.372 Saltbr-na 999.0 HRD-in -81.43, -61.17 83.19, 3.8 na-out-out SNCaoo out-out ActLoopNT-out 8.112 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.59, -38.89 APE9-dihe-out -62.81, -25.28 APE8-dihe-out -84.37, -2.23 APE8-rot-na 213.59 APE67-dihe-out -91.99, 5.73 -72.88, 133.85 APE12-dist-na 9.752 APE11-dist-na 12.229 APE10-dist-na 16.478 APE9-dist-out 11.555 None None None XRAY 2.39 0.205 0.231 B 317 248 41 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzf TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZHA P29597 581 866 1187.0 L9A:4000 Type1 Pseudo DFGin 7.406 12.772 None -62.74, 170.7 -72.48, 150.15 -70.83, -2.83 23.35, 152.01 73.55, -152.26 in-na in 9.497 Saltbr-na 999.0 HRD-in -83.24, -60.86 86.7, -4.43 na-out-out SNCaoo out-out ActLoopNT-out 8.387 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.05, -35.12 APE9-dihe-out -65.62, -29.8 APE8-dihe-out -77.88, -5.55 APE8-rot-na 294.99 APE67-dihe-out -89.76, 4.67 -72.08, 133.72 APE12-dist-na 9.775 APE11-dist-na 12.229 APE10-dist-na 16.47 APE9-dist-out 11.317 None None None XRAY 2.73 0.193 0.215 A 317 249 39 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzh TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZHB P29597 580 867 1187.0 L9A:4000 Type1 Pseudo DFGin 7.436 12.599 None -60.73, 169.6 -71.23, 150.14 -70.46, -1.47 23.31, 151.91 71.77, -152.11 in-na in 9.376 Saltbr-na 999.0 HRD-in -83.11, -60.28 86.79, -5.89 na-out-out SNCaoo out-out ActLoopNT-out 8.308 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.38, -35.33 APE9-dihe-out -65.44, -29.63 APE8-dihe-out -78.49, -5.17 APE8-rot-na 295.66 APE67-dihe-out -89.42, 4.66 -71.76, 134.2 APE12-dist-na 9.735 APE11-dist-na 12.216 APE10-dist-na 16.437 APE9-dist-out 11.269 None None None XRAY 2.73 0.193 0.215 B 317 249 40 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzh TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZPA P29597 580 869 1187.0 LB7:901 Type1 Pseudo DFGin 7.454 12.358 None -74.98, 168.42 -62.51, 146.95 -73.8, -0.03 29.8, 144.9 77.36, -162.45 in-na in 9.216 Saltbr-na 999.0 HRD-in -77.18, -62.62 87.16, 3.67 na-out-out SNCaoo out-out ActLoopNT-out 8.307 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -55.98, -44.81 APE9-dihe-out -54.69, -25.84 APE8-dihe-out -83.74, 2.24 APE8-rot-na 279.61 APE67-dihe-out -91.79, -3.26 -74.14, 129.81 APE12-dist-na 9.758 APE11-dist-na 11.986 APE10-dist-na 16.154 APE9-dist-out 11.555 None None None XRAY 2.35 0.191 0.238 A 317 259 31 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzp TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZPB P29597 580 868 1187.0 LB7:901 Type1 Pseudo DFGin 7.457 12.377 None -74.39, 168.01 -61.52, 147.56 -74.66, 0.45 29.5, 145.4 75.25, -161.58 in-na in 9.288 Saltbr-na 999.0 HRD-in -77.4, -62.3 87.31, 3.57 na-out-out SNCaoo out-out ActLoopNT-out 8.247 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -56.49, -45.45 APE9-dihe-out -54.3, -24.89 APE8-dihe-out -83.35, -4.08 APE8-rot-na 280.62 APE67-dihe-out -91.28, -1.02 -71.12, 130.29 APE12-dist-na 9.773 APE11-dist-na 12.02 APE10-dist-na 16.21 APE9-dist-out 11.556 None None None XRAY 2.35 0.191 0.238 B 317 260 29 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzp TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZQA P29597 580 867 1187.0 LB4:4000 Type1 Pseudo DFGin 7.504 12.4 None -72.22, 171.6 -66.25, 148.31 -74.94, 3.34 30.76, 143.31 66.4, -168.53 in-na in 9.039 Saltbr-na 999.0 HRD-in -79.47, -65.7 83.13, 11.6 na-out-out SNCaoo out-out ActLoopNT-out 8.497 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.2, -35.07 APE9-dihe-out -63.1, -22.48 APE8-dihe-out -87.78, -5.31 APE8-rot-na 268.32 APE67-dihe-out -91.66, 0.19 -69.75, 131.87 APE12-dist-na 9.881 APE11-dist-na 12.092 APE10-dist-na 16.368 APE9-dist-out 11.72 None None None XRAY 2.11 0.199 0.237 A 317 256 33 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzq TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZQB P29597 580 868 1187.0 LB4:4000 Type1 Pseudo DFGin 7.552 12.37 None -70.99, 170.41 -64.59, 148.83 -75.35, 4.18 30.96, 143.54 65.3, -166.93 in-na in 8.958 Saltbr-na 999.0 HRD-in -80.49, -65.88 83.34, 10.69 na-out-out SNCaoo out-out ActLoopNT-out 8.442 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.78, -35.63 APE9-dihe-out -62.43, -22.89 APE8-dihe-out -87.56, -5.29 APE8-rot-na 268.51 APE67-dihe-out -92.56, 0.73 -69.67, 131.53 APE12-dist-na 9.911 APE11-dist-na 12.088 APE10-dist-na 16.439 APE9-dist-out 11.694 None None None XRAY 2.11 0.199 0.237 B 317 258 31 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzq TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7OA P29597 580 867 1187.0 VZJ:901 Type1 Pseudo DFGin 7.366 12.565 None -66.43, 170.03 -67.36, 143.81 -70.91, 1.79 25.53, 145.85 78.47, -152.75 in-na in 9.266 Saltbr-na 999.0 HRD-in -75.49, -66.33 85.17, 12.8 na-out-out SNCaoo out-out ActLoopNT-out 8.181 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -57.32, -40.35 APE9-dihe-out -58.15, -35.87 APE8-dihe-out -71.09, -6.29 APE8-rot-na 289.01 APE67-dihe-out -84.78, -2.19 -73.46, 133.77 APE12-dist-na 9.765 APE11-dist-na 12.088 APE10-dist-na 16.266 APE9-dist-out 11.763 None None None XRAY 2.82 0.181 0.252 A 317 257 32 0 0 0 [[589, 868], [897, 1171]] 2.0 7k7o TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7OB P29597 580 868 1187.0 VZJ:901 Type1 Pseudo DFGin 7.723 12.247 None -71.51, -175.68 -81.24, 151.01 -79.84, 4.8 35.04, 138.85 72.06, -152.96 in-na in 9.264 Saltbr-na 999.0 HRD-in -101.81, -60.3 88.52, -5.44 na-out-out SNCaoo out-out ActLoopNT-out 8.923 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.95, -43.16 APE9-dihe-out -55.55, -22.53 APE8-dihe-out -85.45, 0.22 APE8-rot-na 226.83 APE67-dihe-out -83.49, -4.03 -76.46, 136.55 APE12-dist-na 9.628 APE11-dist-na 12.199 APE10-dist-na 16.268 APE9-dist-out 11.283 None None None XRAY 2.82 0.181 0.252 B 317 257 32 0 0 0 [[589, 868], [897, 1171]] 2.0 7k7o TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7QA P29597 580 867 1187.0 VZG:901 Type1 Pseudo DFGin 7.543 12.533 None -69.2, 167.5 -63.98, 154.51 -77.3, 7.34 29.56, 146.11 63.89, -146.65 in-na in 9.281 Saltbr-na 999.0 HRD-in -79.96, -60.41 88.18, -6.56 na-out-out SNCaoo out-out ActLoopNT-out 8.398 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.8, -37.69 APE9-dihe-out -61.19, -23.02 APE8-dihe-out -86.96, -5.2 APE8-rot-na 283.59 APE67-dihe-out -89.93, 5.32 -68.44, 135.46 APE12-dist-na 9.824 APE11-dist-na 12.119 APE10-dist-na 16.488 APE9-dist-out 11.802 None None None XRAY 2.27 0.191 0.215 A 317 256 33 0 0 0 [[589, 868], [897, 1171]] 2.0 7k7q TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7QB P29597 580 868 1187.0 VZG:901 Type1 Pseudo DFGin 7.528 12.484 None -69.63, 166.47 -62.41, 154.32 -76.74, 6.87 29.05, 146.64 63.93, -146.22 in-na in 9.264 Saltbr-na 999.0 HRD-in -80.84, -60.47 88.54, -6.14 na-out-out SNCaoo out-out ActLoopNT-out 8.387 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.52, -36.89 APE9-dihe-out -61.37, -23.14 APE8-dihe-out -89.62, -0.64 APE8-rot-na 285.2 APE67-dihe-out -89.84, 4.92 -69.09, 135.18 APE12-dist-na 9.785 APE11-dist-na 12.127 APE10-dist-na 16.459 APE9-dist-out 11.701 None None None XRAY 2.27 0.191 0.215 B 317 251 38 0 0 0 [[589, 868], [897, 1171]] 2.0 7k7q TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB5A P29597 580 868 1187.0 ZOQ:902 Type1 Pseudo DFGin 7.575 12.828 None -72.9, 166.16 -62.82, 156.7 -75.2, -1.8 19.44, 155.05 65.85, -157.21 in-na in 9.628 Saltbr-na 999.0 HRD-in -77.18, -55.68 90.86, -17.89 na-out-out SNCaoo out-out ActLoopNT-out 8.033 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.91, -37.05 APE9-dihe-out -64.82, -24.45 APE8-dihe-out -87.22, -2.73 APE8-rot-na 294.55 APE67-dihe-out -99.67, 13.88 -62.74, 133.89 APE12-dist-na 9.966 APE11-dist-na 12.452 APE10-dist-na 16.637 APE9-dist-out 11.819 None None None XRAY 2.32 0.187 0.243 A 326 257 32 0 0 0 [[589, 868], [897, 1171]] 2.0 8tb5 TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB5B P29597 580 868 1187.0 ZOQ:902 Type1 Pseudo DFGin 7.354 12.83 None -69.46, 162.15 -62.48, 155.25 -75.42, -2.04 28.22, 143.07 66.45, -159.8 in-na in 9.655 Saltbr-na 999.0 HRD-in -80.42, -58.38 87.54, 2.75 na-out-out SNCaoo out-out ActLoopNT-out 8.229 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.71, -36.16 APE9-dihe-out -65.57, -18.78 APE8-dihe-out -89.43, 3.6 APE8-rot-na 301.67 APE67-dihe-out -95.11, 8.54 -67.3, 136.04 APE12-dist-na 10.02 APE11-dist-na 12.281 APE10-dist-na 16.5 APE9-dist-out 11.726 None None None XRAY 2.32 0.187 0.243 B 326 257 32 0 0 0 [[589, 868], [897, 1171]] 2.0 8tb5 TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB6A P29597 572 869 1187.0 ZOI:901 Type1 Pseudo DFGin 7.519 12.918 None -70.48, 163.05 -64.31, 156.7 -77.96, 2.63 25.15, 152.72 70.88, -150.51 in-na in 9.757 Saltbr-na 999.0 HRD-in -88.04, -58.25 80.3, 7.16 na-out-out SNCaoo out-out ActLoopNT-out 8.005 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.83, -38.13 APE9-dihe-out -58.13, -23.83 APE8-dihe-out -87.03, -4.8 APE8-rot-na 225.26 APE67-dihe-out -95.58, 10.52 -67.22, 136.28 APE12-dist-na 9.67 APE11-dist-na 12.214 APE10-dist-na 16.343 APE9-dist-out 11.339 None None None XRAY 1.96 0.195 0.236 A 326 263 33 0 0 0 [[589, 868], [897, 1171]] 2.0 8tb6 TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB6B P29597 580 867 1187.0 ZOI:901 Type1 Pseudo DFGin 7.575 12.834 None -75.19, 161.88 -63.62, 154.56 -77.31, 0.0 28.4, 144.85 69.85, -142.97 in-na in 9.746 Saltbr-na 999.0 HRD-in -86.92, -60.13 92.81, -6.33 na-out-out SNCaoo out-out ActLoopNT-out 8.229 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.54, -39.0 APE9-dihe-out -57.31, -25.9 APE8-dihe-out -87.7, -3.61 APE8-rot-na 309.71 APE67-dihe-out -99.75, 10.76 -63.68, 135.57 APE12-dist-na 9.794 APE11-dist-na 12.116 APE10-dist-na 16.334 APE9-dist-out 11.431 None None None XRAY 1.96 0.195 0.236 B 326 254 35 0 0 0 [[589, 868], [897, 1171]] 2.0 8tb6 TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5C01A P29597 580 868 1187.0 UNL:901 Type1 Pseudo DFGin 7.494 12.953 None -78.77, 168.17 -59.3, 158.84 -78.02, -0.56 29.95, 141.01 70.43, -143.96 in-na in 9.86 Saltbr-na 999.0 HRD-in -88.89, -66.71 89.22, 5.88 na-out-out SNCaoo out-out ActLoopNT-out 8.02 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.06, -43.56 APE9-dihe-out -60.5, -24.62 APE8-dihe-out -84.02, 0.04 APE8-rot-na 309.1 APE67-dihe-out -102.6, 18.85 -65.89, 133.72 APE12-dist-na 10.035 APE11-dist-na 12.558 APE10-dist-na 16.715 APE9-dist-out 11.348 None None None XRAY 2.15 0.197 0.24 A 342 258 31 0 0 0 [[589, 868], [897, 1171]] 2.0 5c01 TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5C01B P29597 579 869 1187.0 UNL:901 Type1 Pseudo DFGin 7.503 12.99 None -83.69, 167.93 -60.38, 156.97 -77.3, 1.6 26.16, 146.38 64.95, -141.34 in-na in 9.846 Saltbr-na 999.0 HRD-in -91.02, -62.48 85.42, 13.36 na-out-out SNCaoo out-out ActLoopNT-out 8.054 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.57, -43.79 APE9-dihe-out -56.12, -28.45 APE8-dihe-out -84.03, 3.14 APE8-rot-na 209.42 APE67-dihe-out -101.1, 17.13 -74.09, 134.94 APE12-dist-na 9.989 APE11-dist-na 12.592 APE10-dist-na 16.738 APE9-dist-out 11.636 None None None XRAY 2.15 0.197 0.24 B 342 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 5c01 TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2

Activity: Pseudo (pseudokinase)

Total number of chains: 325
Active chains: 0
Total number of genes: 42
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 140 43.1% 8BA3A
DFGin BLAminus 60 18.5% 9M6GA
DFGin BLBplus 32 9.8% 7JURB
DFGin BLBminus 22 6.8% 9QTUA
None None 21 6.5% 7BL1CCC
DFGin ABAminus 16 4.9% 1TKIA
DFGinter None 15 4.6% 9D5IA
DFGout None 7 2.2% 4I93A
DFGout BBAminus 6 1.8% 6VG3A
DFGin BLAplus 5 1.5% 7JXUA
DFGin BLBtrans 1 0.3% 9BCPB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
OTHER BIR2 BIR2_ARATH 4L68A Q9LSI9 272 600 605.0 PDO:60701 Allosteric Pseudo DFGin 9.12 13.554 BLBminus -102.75, 164.19 78.08, 3.07 -61.21, 134.13 312.77, 999.0 84.79, -0.01 out-out out 13.782 Saltbr-out 15.36 HRD-in -67.43, -47.03 75.0, -5.42 out-out-out SNCooo out-out ActLoopNT-out 5.938 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nioi APE10-dihe-na -95.05, 4.01 APE9-dihe-na 129.54, -165.7 APE8-dihe-in -116.84, 144.73 APE8-rot-na 179.81 APE67-dihe-inflip 91.69, -13.11 -52.03, 129.52 APE12-dist-none 999.0 APE11-dist-in 11.902 APE10-dist-out 15.357 APE9-dist-in 3.82 None None None XRAY 2.0 0.191 0.213 A 340 313 16 0 0 11 [[306, 577]] 1.0 4l68 Arabidopsis thaliana OTHER_BIR2_ARATH TKL 2.4e-44 157.9 4 266 263 446 447 448 450 452 335 350 354 426 428 427 429 490 478 473 472 471 470 469 468 467 380 Inactive LRR receptor-like serine/threonine-protein kinase BIR2
OTHER BIR2 BIR2_ARATH 4L68B Q9LSI9 271 600 605.0 No_ligand No_ligand Pseudo DFGin 9.495 13.641 BLBminus -104.07, 171.02 73.8, -2.3 -55.39, 130.02 301.68, 999.0 88.64, -4.13 out-out out 13.837 Saltbr-out 15.342 HRD-in -71.67, -49.97 80.05, -2.9 out-out-out SNCooo out-out ActLoopNT-out 6.083 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na -93.83, 137.13 APE9-dihe-na -65.39, -157.74 APE8-dihe-out -87.47, -29.3 APE8-rot-na 172.43 APE67-dihe-out 162.38, 161.42 -146.69, 18.8 APE12-dist-out 22.835 APE11-dist-out 27.482 APE10-dist-out 27.665 APE9-dist-out 31.74 None None None XRAY 2.0 0.191 0.213 B 340 320 10 0 0 10 [[306, 577]] 1.0 4l68 Arabidopsis thaliana OTHER_BIR2_ARATH TKL 2.4e-44 157.9 4 266 263 446 447 448 450 452 335 350 354 426 428 427 429 490 478 473 472 471 470 469 468 467 380 Inactive LRR receptor-like serine/threonine-protein kinase BIR2
OTHER BSK8 BSK8_ARATH 4I94A Q9FHD7 40 328 487.0 ANP:60401 ATPlike Pseudo DFGout 11.087 4.579 None -62.85, 129.32 -64.9, -25.87 -61.66, -30.07 297.42, 140.17 -78.36, -1.16 out-out out 12.492 Saltbr-out 11.168 HRD-na-V -138.88, 128.41 -94.79, 85.21 out-out-out SNCooo out-out ActLoopNT-out 8.116 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -112.72, -1.39 APE9-dihe-na -99.73, 174.6 APE8-dihe-in -44.04, 124.87 APE8-rot-na 191.2 APE67-dihe-in -63.8, -11.97 -65.3, -25.56 APE12-dist-in 9.651 APE11-dist-in 13.035 APE10-dist-out 13.738 APE9-dist-out 9.019 None None None XRAY 1.8 0.176 0.218 A 300 289 0 0 0 0 [[64, 311]] 1.0 4i94 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.8e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER BSK8 BSK8_ARATH 4I94B Q9FHD7 40 328 487.0 ANP:60401 ATPlike Pseudo DFGout 11.167 4.564 None -61.22, 131.83 -70.76, -19.93 -64.01, -28.32 298.7, 142.58 -77.56, -3.78 out-out out 12.61 Saltbr-out 11.562 HRD-na-V -138.23, 125.02 -91.22, 87.17 out-out-out SNCooo out-out ActLoopNT-out 8.121 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -107.48, -5.73 APE9-dihe-na -87.26, 179.81 APE8-dihe-in -41.52, 121.65 APE8-rot-na 191.74 APE67-dihe-in -60.71, -19.43 -60.4, -25.91 APE12-dist-in 9.638 APE11-dist-in 12.966 APE10-dist-out 14.136 APE9-dist-out 9.048 None None None XRAY 1.8 0.176 0.218 B 300 289 0 0 0 0 [[64, 311]] 1.0 4i94 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.8e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER BSK8 BSK8_ARATH 4I92A Q9FHD7 40 328 487.0 No_ligand No_ligand Pseudo DFGout 11.158 4.503 None -61.91, 128.06 -64.53, -19.55 -63.02, -32.76 295.83, 136.16 -71.51, -4.32 out-out out 12.243 Saltbr-out 10.618 HRD-na-V -137.1, 130.87 -99.42, 125.04 out-out-out SNCooo out-out ActLoopNT-out 7.549 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooo APE10-dihe-na -72.8, -24.34 APE9-dihe-na -114.6, 124.96 APE8-dihe-in -57.47, 142.35 APE8-rot-na 288.82 APE67-dihe-in -56.47, -25.62 -59.24, -24.8 APE12-dist-in 12.687 APE11-dist-out 17.668 APE10-dist-out 12.461 APE9-dist-out 8.159 None None None XRAY 1.6 0.161 0.183 A 300 289 0 0 0 0 [[64, 311]] 1.0 4i92 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.8e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER BSK8 BSK8_ARATH 4I93A Q9FHD7 40 328 487.0 No_ligand No_ligand Pseudo DFGout 11.427 4.497 None -66.16, 131.32 -65.62, -20.78 -61.54, -32.08 294.88, 141.88 -71.37, -4.79 out-out out 12.372 Saltbr-out 10.901 HRD-na-V -139.73, 134.34 -102.66, 127.15 out-out-out SNCooo out-out ActLoopNT-out 7.578 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -96.34, -20.96 APE9-dihe-na -65.99, 130.67 APE8-dihe-in -66.24, 142.18 APE8-rot-na 187.32 APE67-dihe-in -58.9, -21.18 -65.5, -18.1 APE12-dist-in 13.821 APE11-dist-in 12.207 APE10-dist-out 13.515 APE9-dist-out 8.198 None None MSE115,MSE135,MSE152,MSE156,MSE203,MSE267,MSE269,MSE310 XRAY 1.5 0.181 0.208 A 300 289 0 0 0 0 [[64, 311]] 1.0 4i93 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.8e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER BSK8 BSK8_ARATH 4I93B Q9FHD7 40 328 487.0 No_ligand No_ligand Pseudo DFGout 11.368 4.478 None -62.63, 134.05 -67.17, -20.35 -61.56, -31.26 298.97, 139.62 -77.7, -1.04 out-out out 12.587 Saltbr-out 11.096 HRD-na-V -145.3, 130.74 -99.64, 132.89 out-out-none SNCoon out-none ActLoopNT-out 8.009 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -52.43 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE115,MSE135,MSE152,MSE156,MSE203,MSE267,MSE269,MSE310 XRAY 1.5 0.181 0.208 B 300 283 6 0 0 6 [[64, 311]] 1.0 4i93 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.8e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER MLKL2 Q9FGG5_ARATH 6LBAA Q9FGG5 1 570 711.0 No_ligand No_ligand Pseudo None 6.73 999.0 None -122.97, 148.56 93.16, 0.89 -63.48, -42.05 51.06, 103.73 -82.35, 163.56 none-none none 999.0 Saltbr-none 999.0 HRD-in -59.59, -40.18 73.95, -60.85 none-out-none SNCnon out-none ActLoopNT-out 10.548 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 151.3 APE8-rot-na 30.21 APE67-dihe-in -62.28, -7.76 -72.46, -6.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 4.1 999.0 999.0 A 572 464 74 0 0 13 [[250, 508]] 1.0 6lba Arabidopsis thaliana OTHER_MLKL2_ARATH TKL 8.1e-39 140.1 20 265 246 382 383 384 386 388 265 277 281 356 358 357 359 433 410 405 404 403 402 401 400 399 309 Protein kinase family protein
OTHER MLKL2 Q9FGG5_ARATH 6LBAB Q9FGG5 1 570 711.0 No_ligand No_ligand Pseudo None 6.731 999.0 None -122.97, 148.57 93.19, 0.89 -63.46, -42.1 51.1, 103.74 -82.32, 163.59 none-none none 999.0 Saltbr-none 999.0 HRD-in -59.59, -40.18 73.9, -60.83 none-out-none SNCnon out-none ActLoopNT-out 10.547 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 151.29 APE8-rot-na 30.18 APE67-dihe-in -62.24, -7.82 -72.49, -6.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 4.1 999.0 999.0 B 572 464 74 0 0 13 [[250, 508]] 1.0 6lba Arabidopsis thaliana OTHER_MLKL2_ARATH TKL 8.1e-39 140.1 20 265 246 382 383 384 386 388 265 277 281 356 358 357 359 433 410 405 404 403 402 401 400 399 309 Protein kinase family protein
OTHER MLKL2 Q9FGG5_ARATH 6LBAC Q9FGG5 1 570 711.0 No_ligand No_ligand Pseudo None 6.731 999.0 None -123.02, 148.57 93.19, 0.88 -63.44, -42.08 51.11, 103.72 -82.32, 163.57 none-none none 999.0 Saltbr-none 999.0 HRD-in -59.58, -40.22 73.99, -60.87 none-out-none SNCnon out-none ActLoopNT-out 10.549 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 151.3 APE8-rot-na 30.19 APE67-dihe-in -62.3, -7.76 -72.5, -6.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 4.1 999.0 999.0 C 572 464 74 0 0 13 [[250, 508]] 1.0 6lba Arabidopsis thaliana OTHER_MLKL2_ARATH TKL 8.1e-39 140.1 20 265 246 382 383 384 386 388 265 277 281 356 358 357 359 433 410 405 404 403 402 401 400 399 309 Protein kinase family protein
OTHER MLKL2 Q9FGG5_ARATH 6LBAD Q9FGG5 1 570 711.0 No_ligand No_ligand Pseudo None 6.73 999.0 None -123.01, 148.57 93.2, 0.79 -63.42, -42.02 51.11, 103.73 -82.4, 163.58 none-none none 999.0 Saltbr-none 999.0 HRD-in -59.58, -40.22 73.98, -60.84 none-out-none SNCnon out-none ActLoopNT-out 10.548 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 151.34 APE8-rot-na 30.2 APE67-dihe-in -62.23, -7.79 -72.5, -6.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 4.1 999.0 999.0 D 572 464 74 0 0 13 [[250, 508]] 1.0 6lba Arabidopsis thaliana OTHER_MLKL2_ARATH TKL 8.1e-39 140.1 20 265 246 382 383 384 386 388 265 277 281 356 358 357 359 433 410 405 404 403 402 401 400 399 309 Protein kinase family protein
OTHER MLKL3 Q9LMN2_ARATH 6KA4A Q9LMN2 325 900 1025.0 No_ligand No_ligand Pseudo None 6.802 999.0 None -142.13, 171.5 85.9, 1.28 -63.61, -40.11 50.83, 88.77 -77.79, 165.1 none-na none 999.0 Saltbr-na 999.0 HRD-out -64.16, 132.9 -63.4, -51.31 na-out-out SNCaoo out-out ActLoopNT-out 9.485 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -117.65 APE8-rot-na 24.5 APE67-dihe-out -127.8, -55.85 -82.83, 72.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 A 701 534 34 0 0 17 [[570, 833]] 1.0 6ka4 Arabidopsis thaliana OTHER_MLKL3_ARATH TKL 3.4e-35 128.8 50 265 216 705 706 707 709 711 0 0 602 677 679 678 680 758 737 732 731 730 729 728 727 726 630 F22L4.1 protein
OTHER MLKL3 Q9LMN2_ARATH 6KA4B Q9LMN2 325 900 1025.0 No_ligand No_ligand Pseudo None 6.802 999.0 None -142.18, 171.46 85.97, 1.26 -63.61, -40.11 50.83, 88.78 -77.79, 165.1 none-na none 999.0 Saltbr-na 999.0 HRD-out -64.14, 132.89 -63.44, -51.21 na-out-out SNCaoo out-out ActLoopNT-out 9.485 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -117.63 APE8-rot-na 24.5 APE67-dihe-out -127.76, -55.87 -82.87, 72.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 B 701 534 34 0 0 17 [[570, 833]] 1.0 6ka4 Arabidopsis thaliana OTHER_MLKL3_ARATH TKL 3.4e-35 128.8 50 265 216 705 706 707 709 711 0 0 602 677 679 678 680 758 737 732 731 730 729 728 727 726 630 F22L4.1 protein
OTHER MLKL3 Q9LMN2_ARATH 6KA4C Q9LMN2 325 900 1025.0 No_ligand No_ligand Pseudo None 6.801 999.0 None -142.14, 171.51 85.88, 1.33 -63.66, -40.1 50.84, 88.73 -77.78, 165.14 none-na none 999.0 Saltbr-na 999.0 HRD-out -64.18, 132.86 -63.33, -51.38 na-out-out SNCaoo out-out ActLoopNT-out 9.485 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -117.58 APE8-rot-na 24.47 APE67-dihe-out -127.78, -55.8 -82.92, 72.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 C 701 534 34 0 0 17 [[570, 833]] 1.0 6ka4 Arabidopsis thaliana OTHER_MLKL3_ARATH TKL 3.4e-35 128.8 50 265 216 705 706 707 709 711 0 0 602 677 679 678 680 758 737 732 731 730 729 728 727 726 630 F22L4.1 protein
OTHER MLKL3 Q9LMN2_ARATH 6KA4D Q9LMN2 325 900 1025.0 No_ligand No_ligand Pseudo None 6.803 999.0 None -142.12, 171.53 85.87, 1.26 -63.58, -40.16 50.84, 88.79 -77.77, 165.1 none-na none 999.0 Saltbr-na 999.0 HRD-out -64.2, 132.96 -63.47, -51.27 na-out-out SNCaoo out-out ActLoopNT-out 9.486 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -117.62 APE8-rot-na 24.59 APE67-dihe-out -127.79, -55.89 -82.86, 72.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 D 701 534 34 0 0 17 [[570, 833]] 1.0 6ka4 Arabidopsis thaliana OTHER_MLKL3_ARATH TKL 3.4e-35 128.8 50 265 216 705 706 707 709 711 0 0 602 677 679 678 680 758 737 732 731 730 729 728 727 726 630 F22L4.1 protein
OTHER STKLD1 F1MSZ0_BOVIN 9FQRXR F1MSZ0 1 610 639.0 No_ligand No_ligand Pseudo DFGin 6.896 13.145 BLBminus -134.69, 167.6 69.62, 51.59 -66.55, 132.48 297.73, 161.29 -107.87, 152.84 out-out out 14.762 Saltbr-out 12.944 HRD-in -60.65, -50.75 79.55, -12.94 out-out-out SNCooo out-out ActLoopNT-out 9.598 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -53.75, -17.84 APE9-dihe-na -83.29, -27.47 APE8-dihe-out -101.65, -16.85 APE8-rot-na 289.97 APE67-dihe-in -73.99, -1.71 -81.73, -21.53 APE12-dist-out 20.029 APE11-dist-out 19.061 APE10-dist-out 22.971 APE9-dist-out 14.584 None None None EM 5.0 999.0 999.0 Xr 756 579 21 0 0 0 [[4, 271]] 1.0 9fqr Bos taurus OTHER_STKLD1_BOVIN STE 3e-31 115.2 5 257 253 150 151 152 154 156 33 49 53 130 132 131 133 192 181 176 175 174 173 172 171 170 85 Serine/threonine kinase like domain containing 1
OTHER PAN3 PAN3_CHATD 4CYIA G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.585 12.852 None -92.38, -13.16 -130.85, 61.75 -94.99, 144.51 286.93, 999.0 79.52, -4.52 out-na out 13.591 Saltbr-na 999.0 HRD-out -83.98, 84.54 -50.92, -35.91 na-out-na SNCaoa out-na ActLoopNT-out 7.062 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -80.88, -42.8 APE9-dihe-na -64.32, -40.93 APE8-dihe-na -99.24, 17.32 APE8-rot-na 300.48 APE67-dihe-na -73.05, -48.17 -58.31, -53.55 APE12-dist-na 4.897 APE11-dist-na 5.543 APE10-dist-na 5.105 APE9-dist-na 11.572 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 A 438 405 0 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIB G0S0Y3 213 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.616 12.918 None -91.62, -15.83 -130.65, 63.54 -94.89, 145.11 286.33, 999.0 77.48, -4.88 out-na out 13.58 Saltbr-na 999.0 HRD-out -84.8, 85.11 -51.08, -35.56 na-out-na SNCaoa out-na ActLoopNT-out 7.175 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -82.17, -41.93 APE9-dihe-na -64.26, -40.58 APE8-dihe-na -98.12, 16.28 APE8-rot-na 298.69 APE67-dihe-na 80.12, -45.62 -60.06, 122.74 APE12-dist-na 4.893 APE11-dist-na 5.478 APE10-dist-na 5.079 APE9-dist-na 11.87 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 B 438 406 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIC G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.492 12.647 None -89.83, -13.71 -129.71, 95.5 -125.66, 144.13 285.48, 999.0 76.65, -4.79 out-na out 13.568 Saltbr-na 999.0 HRD-out -84.9, 84.38 -51.27, -35.99 na-out-na SNCaoa out-na ActLoopNT-out 7.036 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.46, -42.97 APE9-dihe-na -65.29, -40.87 APE8-dihe-na -98.03, 18.1 APE8-rot-na 300.5 APE67-dihe-na -80.64, -42.62 -57.0, -52.24 APE12-dist-na 4.87 APE11-dist-na 5.412 APE10-dist-na 5.104 APE9-dist-na 11.702 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 C 438 397 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYID G0S0Y3 214 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.581 12.83 None -92.56, -14.61 -129.54, 61.33 -91.03, 145.16 286.17, 999.0 78.34, -3.87 out-na out 13.632 Saltbr-na 999.0 HRD-out -84.73, 84.5 -51.45, -36.17 na-out-na SNCaoa out-na ActLoopNT-out 6.98 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -82.5, -42.63 APE9-dihe-na -63.84, -39.93 APE8-dihe-na -97.69, 15.27 APE8-rot-na 300.06 APE67-dihe-na 82.88, -51.63 -61.5, 124.95 APE12-dist-na 4.849 APE11-dist-na 5.59 APE10-dist-na 5.161 APE9-dist-na 11.613 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 D 438 407 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIE G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.538 12.767 None -90.87, -14.73 -130.14, 65.48 -95.4, 143.11 286.9, 999.0 77.19, -4.14 out-na out 13.933 Saltbr-na 999.0 HRD-out -83.54, 85.23 -50.62, -36.04 na-out-na SNCaoa out-na ActLoopNT-out 6.962 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.29, -42.51 APE9-dihe-na -65.13, -42.05 APE8-dihe-na -99.46, 17.91 APE8-rot-na 300.53 APE67-dihe-na -82.88, -16.1 -58.82, -52.89 APE12-dist-na 4.867 APE11-dist-na 5.506 APE10-dist-na 4.99 APE9-dist-na 11.652 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 E 438 394 10 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIF G0S0Y3 213 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.657 12.928 None -90.71, -14.62 -131.6, 64.5 -94.2, 145.33 287.42, 999.0 78.97, -5.05 out-na out 13.619 Saltbr-na 999.0 HRD-out -84.32, 83.81 -51.72, -36.16 na-out-na SNCaoa out-na ActLoopNT-out 7.068 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.37, -43.07 APE9-dihe-na -65.03, -40.26 APE8-dihe-na -97.58, 14.32 APE8-rot-na 301.7 APE67-dihe-na 82.79, -63.67 -61.76, 133.26 APE12-dist-na 4.897 APE11-dist-na 5.471 APE10-dist-na 4.981 APE9-dist-na 11.745 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 F 438 408 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIG G0S0Y3 212 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.345 12.727 None -90.69, -14.9 -130.76, 66.96 -94.98, 143.34 287.45, 999.0 77.29, -3.15 out-na out 13.686 Saltbr-na 999.0 HRD-out -84.86, 86.26 -50.94, -35.45 na-out-na SNCaoa out-na ActLoopNT-out 6.956 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.27, -42.88 APE9-dihe-na -64.53, -40.74 APE8-dihe-na -98.57, 20.38 APE8-rot-na 300.7 APE67-dihe-na -82.95, -50.87 -54.99, -52.34 APE12-dist-na 4.886 APE11-dist-na 5.441 APE10-dist-na 4.99 APE9-dist-na 11.838 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 G 438 397 11 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIH G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.548 12.993 None -92.58, -12.35 -130.21, 41.87 -74.5, 144.28 287.27, 999.0 78.55, -5.47 out-na out 13.565 Saltbr-na 999.0 HRD-out -84.2, 83.95 -50.63, -35.15 na-out-na SNCaoa out-na ActLoopNT-out 7.113 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.74, -43.44 APE9-dihe-na -64.3, -40.98 APE8-dihe-na -98.31, 13.33 APE8-rot-na 300.84 APE67-dihe-na 84.19, -53.66 -61.5, 130.17 APE12-dist-na 4.897 APE11-dist-na 5.551 APE10-dist-na 5.004 APE9-dist-na 11.679 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 H 438 407 7 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJA G0S0Y3 207 630 640.0 ATP:900 ATPlike Pseudo DFGin 8.634 13.143 None -107.98, -0.69 -128.2, 34.36 -65.03, -50.53 266.85, 999.0 -67.72, -27.44 out-na out 13.824 Saltbr-na 999.0 HRD-out -72.25, 117.57 -98.06, -29.9 na-out-na SNCaoa out-na ActLoopNT-out 6.734 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -76.94, -48.66 APE9-dihe-na -63.83, -32.83 APE8-dihe-na -105.44, 19.22 APE8-rot-na 294.5 APE67-dihe-na -75.63, -42.57 -53.51, -50.74 APE12-dist-na 4.896 APE11-dist-na 5.565 APE10-dist-na 4.767 APE9-dist-na 12.093 None None None XRAY 2.59 0.185 0.221 A 438 403 9 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJB G0S0Y3 207 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.657 13.407 None -109.51, -3.14 -128.47, 33.06 -65.31, -51.07 267.08, 999.0 -68.09, -25.9 out-na out 13.607 Saltbr-na 999.0 HRD-out -72.34, 112.57 -93.58, -28.7 na-out-na SNCaoa out-na ActLoopNT-out 6.74 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.81, -47.86 APE9-dihe-na -64.66, -32.92 APE8-dihe-na -101.7, 13.23 APE8-rot-na 292.51 APE67-dihe-na 83.46, -7.05 -62.34, 118.45 APE12-dist-na 4.827 APE11-dist-na 5.687 APE10-dist-na 4.961 APE9-dist-na 11.892 None None None XRAY 2.59 0.185 0.221 B 438 412 10 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJC G0S0Y3 210 632 640.0 ATP:900 ATPlike Pseudo DFGin 8.673 13.164 None -108.29, -3.21 -129.06, 34.16 -64.55, -50.26 267.61, 999.0 -68.23, -27.03 out-na out 13.722 Saltbr-na 999.0 HRD-out -71.32, 109.68 -92.82, -27.84 na-out-na SNCaoa out-na ActLoopNT-out 6.928 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -75.12, -48.05 APE9-dihe-na -64.49, -35.42 APE8-dihe-na -104.77, 18.2 APE8-rot-na 294.69 APE67-dihe-na -54.66, -46.82 -53.38, -67.98 APE12-dist-na 4.886 APE11-dist-na 5.663 APE10-dist-na 4.931 APE9-dist-na 11.895 None None None XRAY 2.59 0.185 0.221 C 438 404 8 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJD G0S0Y3 207 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.73 13.246 None -109.91, -2.89 -127.7, 32.83 -63.98, -50.83 267.28, 999.0 -68.06, -27.82 out-na out 13.683 Saltbr-na 999.0 HRD-out -71.89, 115.33 -92.98, -30.13 na-out-na SNCaoa out-na ActLoopNT-out 6.66 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.1, -45.9 APE9-dihe-na -60.82, -48.55 APE8-dihe-na -95.53, 14.82 APE8-rot-na 272.71 APE67-dihe-na -68.99, -42.68 -59.32, -45.4 APE12-dist-na 4.893 APE11-dist-na 5.689 APE10-dist-na 4.875 APE9-dist-na 11.937 None None None XRAY 2.59 0.185 0.221 D 438 411 11 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER POMK SG196_DANRE 5GZAA Q5U3W1 53 342 347.0 ADP:401,ZZ1:405 ATPlike,Allosteric Pseudo DFGin 5.357 13.174 None -145.49, -53.43 -88.36, 87.6 -105.44, 34.02 303.67, 0.43 -66.19, -35.84 none-na none 999.0 Saltbr-na 999.0 HRD-out -76.02, 100.34 -84.46, -37.81 na-in-out SNCaio in-out ActLoopNT-in 3.176 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iioo APE10-dihe-na -72.0, 131.22 APE9-dihe-na -98.58, 149.02 APE8-dihe-in -137.88, 170.05 APE8-rot-out 49.36 APE67-dihe-out -89.83, -15.07 100.95, 169.89 APE12-dist-in 12.164 APE11-dist-in 13.936 APE10-dist-out 17.359 APE9-dist-out 9.415 None None None XRAY 2.0 0.203 0.218 A 290 290 0 0 0 0 [[72, 335]] 1.0 5gza Danio rerio OTHER_POMK_DANRE POMK 3.3e-138 465.4 1 265 265 224 225 226 228 230 106 120 124 199 201 200 202 278 254 249 248 247 246 245 244 243 148 Protein O-mannose kinase
CAMK OBSCN-1 OBSCN_DROME 8AK3A A8DYP0 3186 3477 4218.0 ADP:63501 ATPlike Pseudo DFGin 5.905 13.485 BLAminus -132.07, -172.8 60.67, 81.34 -101.92, 21.49 307.26, 110.13 -57.27, -33.59 in-in in 7.72 Saltbr-in 2.761 HRD-in -74.37, -46.4 81.73, -14.06 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -140.07, 151.0 APE9-dihe-na 162.46, 172.55 APE8-dihe-in -86.0, 119.15 APE8-rot-na 203.36 APE67-dihe-in -78.57, -5.95 -56.15, -31.0 APE12-dist-in 8.047 APE11-dist-in 10.008 APE10-dist-in 6.691 APE9-dist-in 5.787 None None None XRAY 1.9 0.175 0.208 A 297 292 0 0 0 0 [[3186, 3440], [3897, 4151]] 2.0 8ak3 Drosophila melanogaster CAMK_OBSCN-1_DROME CAMK 2.3e-61 213.3 1 256 256 3325 3326 3327 3329 3331 3215 3230 3234 3303 3305 3304 3306 3364 3352 3347 3346 3345 3344 3343 3342 3341 3260 Protein Obscurin
CAMK OBSCN-1 OBSCN_DROME 8AK2A A8DYP0 3186 3472 4218.0 No_ligand No_ligand Pseudo DFGin 5.977 13.478 BLAminus -134.63, -178.36 66.29, 80.8 -103.79, 23.35 307.44, 112.56 -60.88, -31.91 in-in in 7.823 Saltbr-in 2.898 HRD-in -73.1, -49.0 81.01, -10.4 in-in-in SNCiii in-in ActLoopNT-in 2.932 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -139.39, 154.37 APE9-dihe-na 158.35, 172.94 APE8-dihe-in -85.52, 121.03 APE8-rot-na 202.35 APE67-dihe-in -76.68, -5.09 -59.31, -30.09 APE12-dist-in 8.083 APE11-dist-in 9.959 APE10-dist-in 6.785 APE9-dist-in 5.824 None None None XRAY 1.75 0.175 0.196 A 297 287 0 0 0 0 [[3186, 3440], [3897, 4151]] 2.0 8ak2 Drosophila melanogaster CAMK_OBSCN-1_DROME CAMK 2.3e-61 213.3 1 256 256 3325 3326 3327 3329 3331 3215 3230 3234 3303 3305 3304 3306 3364 3352 3347 3346 3345 3344 3343 3342 3341 3260 Protein Obscurin
OTHER PAN3 PAN3_DROME 4BWPA Q95RR8 379 787 790.0 AN2:1788 ATPlike Pseudo DFGin 8.987 13.294 None -64.87, -46.72 -145.48, 65.79 -71.61, -40.0 313.19, 999.0 -67.11, -37.22 out-na out 16.832 Saltbr-na 999.0 HRD-in -50.58, -30.55 79.2, -55.76 na-out-na SNCaoa out-na ActLoopNT-out 6.698 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -83.44, -6.17 APE9-dihe-na -63.0, 138.21 APE8-dihe-na -120.41, 140.18 APE8-rot-na 194.81 APE67-dihe-na -113.46, 118.54 -59.4, -45.27 APE12-dist-na 5.306 APE11-dist-na 5.827 APE10-dist-na 8.834 APE9-dist-na 12.341 None None None XRAY 3.6 0.222 0.269 A 448 386 23 0 0 0 [[378, 664]] 1.0 4bwp Drosophila melanogaster OTHER_PAN3_DROME PAN3 1.2e-113 385.1 1 288 288 564 565 566 568 570 423 438 442 545 547 546 548 592 582 577 576 575 574 573 572 571 472 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_DROME 4BWPB Q95RR8 379 787 790.0 AN2:1788 ATPlike Pseudo DFGin 9.736 13.981 None -68.02, -47.7 -135.41, 45.28 -65.56, -36.8 296.47, 999.0 -63.81, -39.61 out-na out 16.544 Saltbr-na 999.0 HRD-in -58.26, -35.46 80.55, -56.51 na-out-na SNCaoa out-na ActLoopNT-out 5.962 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -88.2, -6.77 APE9-dihe-na -69.16, 143.64 APE8-dihe-na -96.5, 127.2 APE8-rot-na 212.33 APE67-dihe-na -115.77, 110.79 -63.6, -38.16 APE12-dist-na 4.419 APE11-dist-na 6.01 APE10-dist-na 8.854 APE9-dist-na 11.29 None None None XRAY 3.6 0.222 0.269 B 448 372 26 0 0 0 [[378, 664]] 1.0 4bwp Drosophila melanogaster OTHER_PAN3_DROME PAN3 1.2e-113 385.1 1 288 288 564 565 566 568 570 423 438 442 545 547 546 548 592 582 577 576 575 574 573 572 571 472 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER MLKL F6S337_HORSE 6VC0A F6S337 258 536 543.0 No_ligand No_ligand Pseudo DFGin 4.988 13.881 BLBminus -160.47, -177.36 65.51, 36.37 -58.39, 137.28 318.13, 86.77 58.83, -124.64 in-in in 7.643 Saltbr-in 2.677 HRD-na-E -62.53, -41.81 82.08, -6.9 in-out-out SNCioo out-out ActLoopNT-out 13.362 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -88.0, 120.78 APE9-dihe-na -72.95, 148.97 APE8-dihe-out -64.67, -29.31 APE8-rot-in 286.85 APE67-dihe-in -52.64, -29.19 -53.47, -31.2 APE12-dist-in 12.067 APE11-dist-out 17.622 APE10-dist-out 15.015 APE9-dist-out 13.613 None None None XRAY 2.746 0.175 0.238 A 292 272 7 0 0 7 [[272, 535]] 1.0 6vc0 Equus caballus OTHER_MLKL_HORSE TKL 2.5e-50 177.4 7 266 260 415 416 417 419 421 296 316 320 395 397 396 398 461 447 442 441 440 439 438 437 436 350 Mixed lineage kinase domain like pseudokinase
OTHER MLKL F6S337_HORSE 6VC0B F6S337 258 537 543.0 No_ligand No_ligand Pseudo DFGin 5.138 14.211 BLBminus -147.23, -169.43 57.25, 44.02 -61.21, 135.2 309.04, 84.31 57.69, -129.98 in-in in 7.975 Saltbr-in 3.151 HRD-na-E -65.25, -45.35 82.07, -9.74 in-out-out SNCioo out-out ActLoopNT-out 13.481 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -126.45, 116.02 APE9-dihe-na -51.25, 124.58 APE8-dihe-out -50.77, -33.76 APE8-rot-in 297.7 APE67-dihe-in -54.8, -30.44 -56.98, -22.96 APE12-dist-none 999.0 APE11-dist-out 16.172 APE10-dist-out 15.204 APE9-dist-out 13.714 None None None XRAY 2.746 0.175 0.238 B 292 269 11 0 0 11 [[272, 535]] 1.0 6vc0 Equus caballus OTHER_MLKL_HORSE TKL 2.5e-50 177.4 7 266 260 415 416 417 419 421 296 316 320 395 397 396 398 461 447 442 441 440 439 438 437 436 350 Mixed lineage kinase domain like pseudokinase
OTHER MLKL F6S337_HORSE 6VC0C F6S337 258 541 543.0 No_ligand No_ligand Pseudo DFGin 5.403 14.135 BLBminus -139.49, -162.99 63.64, 39.99 -70.44, 152.53 306.23, 102.18 57.77, 37.75 in-in in 7.883 Saltbr-in 2.77 HRD-na-E -65.22, -39.62 76.85, -6.27 in-out-out SNCioo out-out ActLoopNT-out 13.68 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -63.28, 135.92 APE9-dihe-na -86.15, 145.34 APE8-dihe-out -56.36, -39.87 APE8-rot-in 295.41 APE67-dihe-in -54.7, -29.08 -59.22, -20.61 APE12-dist-in 12.868 APE11-dist-out 17.817 APE10-dist-out 15.143 APE9-dist-out 13.226 None None None XRAY 2.746 0.175 0.238 C 292 271 13 0 0 8 [[272, 535]] 1.0 6vc0 Equus caballus OTHER_MLKL_HORSE TKL 2.5e-50 177.4 7 266 260 415 416 417 419 421 296 316 320 395 397 396 398 461 447 442 441 440 439 438 437 436 350 Mixed lineage kinase domain like pseudokinase
CAMK CASK CSKP_HUMAN 3MFRA O14936 5 306 926.0 ANP:500 ATPlike Pseudo DFGin 7.288 14.824 BLAminus -130.01, -163.55 44.45, 79.28 -92.76, 26.16 280.97, 75.37 -59.27, -25.64 in-in in 9.502 Saltbr-in 2.799 HRD-in -78.83, -45.71 73.64, -1.18 in-in-in SNCiii in-in ActLoopNT-in 2.998 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.41, 141.74 APE9-dihe-na 116.11, -155.43 APE8-dihe-in -114.21, 120.95 APE8-rot-in 305.84 APE67-dihe-in -66.35, -20.44 -39.68, -44.71 APE12-dist-in 11.987 APE11-dist-in 12.403 APE10-dist-in 6.658 APE9-dist-in 3.593 P22A,H145E,C146N,G162D None None XRAY 2.0 0.198 0.241 A 351 302 0 0 0 0 [[12, 276]] 1.0 3mfr Homo sapiens CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3MFSA O14936 4 306 926.0 ANP:500 ATPlike Pseudo DFGin 7.121 14.917 BLAminus -132.54, -159.47 54.72, 71.28 -90.49, 27.88 285.64, 73.35 -63.01, -24.88 in-in in 9.855 Saltbr-in 3.256 HRD-in -74.69, -45.24 69.87, -1.37 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.15, 142.33 APE9-dihe-na 119.56, -149.24 APE8-dihe-in -110.99, 115.07 APE8-rot-in 303.42 APE67-dihe-in -55.02, -32.56 -38.77, -44.89 APE12-dist-in 12.085 APE11-dist-in 12.3 APE10-dist-in 6.637 APE9-dist-in 3.634 P22A,H145E,C146N,G162D None None XRAY 2.1 0.221 0.268 A 351 303 0 0 0 0 [[12, 276]] 1.0 3mfs Homo sapiens CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3MFUA O14936 5 306 926.0 ANP:500 ATPlike Pseudo DFGin 7.162 14.979 BLAminus -132.46, -169.21 51.97, 75.16 -95.02, 30.45 283.47, 72.96 -64.45, -32.11 in-in in 9.439 Saltbr-in 3.206 HRD-in -76.17, -45.52 71.72, -5.88 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.79, 142.93 APE9-dihe-na 117.49, -160.73 APE8-dihe-in -102.18, 121.4 APE8-rot-in 298.46 APE67-dihe-in -63.89, -19.89 -44.81, -44.73 APE12-dist-in 12.084 APE11-dist-in 12.195 APE10-dist-in 6.449 APE9-dist-in 3.737 P22A,H145E,C146N,G162D None None XRAY 2.3 0.182 0.234 A 351 302 0 0 0 0 [[12, 276]] 1.0 3mfu Homo sapiens CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 9M6GA O14936 5 312 926.0 ANP:401 ATPlike Pseudo DFGin 7.452 15.114 BLAminus -123.77, -152.06 75.54, 37.97 -87.68, 22.87 280.47, 84.05 -71.57, -12.61 in-in in 9.6 Saltbr-in 2.897 HRD-in -79.25, -45.64 76.25, -8.72 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.23, 151.66 APE9-dihe-na 106.36, -155.68 APE8-dihe-in -120.97, 120.76 APE8-rot-in 297.98 APE67-dihe-in -62.79, -20.16 -47.6, -44.68 APE12-dist-in 12.42 APE11-dist-in 12.215 APE10-dist-in 6.65 APE9-dist-in 3.645 None None None XRAY 1.7 0.167 0.187 A 325 308 0 0 0 0 [[12, 276]] 1.0 9m6g Homo sapiens CAMK_CASK_HUMAN CAMK 4.9e-82 281.1 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 9M5YA O14936 3 312 926.0 ANP:401 ATPlike Pseudo DFGin 7.714 15.512 BLAminus -121.67, -150.51 71.79, 35.46 -86.15, 22.59 279.83, 82.24 -67.65, -16.3 in-in in 9.959 Saltbr-in 2.867 HRD-in -79.78, -48.63 75.37, -2.97 in-in-in SNCiii in-in ActLoopNT-in 3.012 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.65, 147.9 APE9-dihe-na 109.7, -155.33 APE8-dihe-in -121.16, 120.88 APE8-rot-in 298.99 APE67-dihe-in -58.84, -21.41 -46.45, -46.8 APE12-dist-in 12.687 APE11-dist-in 12.279 APE10-dist-in 6.857 APE9-dist-in 3.592 None None None XRAY 1.8 0.168 0.197 A 338 310 0 0 0 0 [[12, 276]] 1.0 9m5y Homo sapiens CAMK_CASK_HUMAN CAMK 5.6e-82 280.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3C0HA O14936 5 304 926.0 AMP:338 ATPlike Pseudo DFGin 7.602 15.272 BLAminus -127.83, -151.84 62.45, 48.02 -88.8, 12.97 279.71, 88.33 -53.45, -27.37 in-in in 9.984 Saltbr-in 3.32 HRD-in -71.81, -47.22 72.01, -10.53 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.88, 145.94 APE9-dihe-na 100.98, -162.69 APE8-dihe-in -107.97, 118.32 APE8-rot-in 308.41 APE67-dihe-in -60.72, -23.96 -42.45, -43.89 APE12-dist-in 13.036 APE11-dist-in 12.314 APE10-dist-in 6.82 APE9-dist-in 3.701 None None None XRAY 2.3 0.191 0.239 A 351 300 0 0 0 0 [[12, 276]] 1.0 3c0h Homo sapiens CAMK_CASK_HUMAN CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3C0HB O14936 5 304 926.0 AMP:338 ATPlike Pseudo DFGin 7.6 15.203 BLAminus -120.68, -148.62 53.86, 55.42 -94.09, 23.7 283.84, 83.03 -57.86, -26.99 in-in in 9.535 Saltbr-in 3.011 HRD-in -71.85, -49.31 73.45, -6.5 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.66, 151.11 APE9-dihe-na 98.76, -158.5 APE8-dihe-in -113.67, 120.11 APE8-rot-in 310.97 APE67-dihe-in -61.76, -24.04 -43.49, -43.68 APE12-dist-in 12.992 APE11-dist-in 12.203 APE10-dist-in 6.64 APE9-dist-in 3.716 None None None XRAY 2.3 0.191 0.239 B 351 300 0 0 0 0 [[12, 276]] 1.0 3c0h Homo sapiens CAMK_CASK_HUMAN CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3MFTA O14936 5 306 926.0 No_ligand No_ligand Pseudo DFGin 7.292 14.834 BLAminus -131.32, -156.93 44.41, 78.42 -93.33, 28.62 283.5, 69.48 -53.43, -36.46 in-in in 9.413 Saltbr-in 2.791 HRD-in -75.72, -50.07 74.15, 5.93 in-in-in SNCiii in-in ActLoopNT-in 3.038 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.73, 139.71 APE9-dihe-na 123.53, -152.17 APE8-dihe-in -117.17, 118.77 APE8-rot-in 308.79 APE67-dihe-in -61.5, -22.26 -37.69, -50.03 APE12-dist-in 12.268 APE11-dist-in 12.181 APE10-dist-in 6.364 APE9-dist-in 3.608 P22A,H145E,C146N,G162D None None XRAY 2.2 0.214 0.27 A 351 302 0 0 0 0 [[12, 276]] 1.0 3mft Homo sapiens CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 6KMHA O14936 5 318 926.0 No_ligand No_ligand Pseudo DFGin 7.083 16.159 BLAminus -123.3, -153.22 66.24, 45.44 -87.94, 23.97 285.47, 87.97 -59.86, -25.49 out-in out 10.172 Saltbr-in 2.752 HRD-in -83.12, -49.07 74.39, -8.24 in-in-in SNCiii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.22, 147.02 APE9-dihe-na 100.62, -151.8 APE8-dihe-in -117.26, 118.55 APE8-rot-in 310.89 APE67-dihe-in -65.56, -17.16 -41.82, -48.34 APE12-dist-in 12.295 APE11-dist-in 12.037 APE10-dist-in 6.476 APE9-dist-in 3.927 None None None XRAY 2.4 0.19 0.224 A 325 314 0 0 0 0 [[12, 276]] 1.0 6kmh Homo sapiens CAMK_CASK_HUMAN CAMK 4.9e-82 281.1 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 6KMHB O14936 5 319 926.0 No_ligand No_ligand Pseudo DFGin 7.466 16.082 BLAminus -119.05, -153.46 64.87, 44.2 -87.52, 21.7 281.92, 86.46 -59.52, -24.1 out-in out 10.255 Saltbr-in 3.118 HRD-in -83.29, -47.47 74.84, -8.44 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.47, 146.66 APE9-dihe-na 101.89, -151.28 APE8-dihe-in -117.25, 119.53 APE8-rot-in 313.99 APE67-dihe-in -66.53, -18.26 -39.52, -48.38 APE12-dist-in 12.389 APE11-dist-in 12.168 APE10-dist-in 6.592 APE9-dist-in 3.75 None None None XRAY 2.4 0.19 0.224 B 325 315 0 0 0 0 [[12, 276]] 1.0 6kmh Homo sapiens CAMK_CASK_HUMAN CAMK 4.9e-82 281.1 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 8Y68A O14936 5 326 926.0 No_ligand No_ligand Pseudo DFGin 7.593 16.272 BLAminus -122.61, -155.23 66.8, 41.14 -86.85, 31.1 288.8, 86.07 -70.48, -25.66 out-in out 10.254 Saltbr-in 3.162 HRD-in -77.53, -51.01 74.47, 3.49 in-in-in SNCiii in-in ActLoopNT-in 3.057 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.69, 141.68 APE9-dihe-na 112.97, -158.9 APE8-dihe-in -109.43, 127.51 APE8-rot-in 305.09 APE67-dihe-in -63.9, -19.3 -52.54, -41.88 APE12-dist-in 12.447 APE11-dist-in 12.496 APE10-dist-in 6.811 APE9-dist-in 3.643 None None None XRAY 2.2 0.239 0.264 A 338 314 0 0 0 0 [[12, 276]] 1.0 8y68 Homo sapiens CAMK_CASK_HUMAN CAMK 5.6e-82 280.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 8Y68B O14936 5 326 926.0 No_ligand No_ligand Pseudo DFGin 7.601 16.256 BLAminus -125.55, -154.73 72.48, 30.93 -72.18, 9.57 291.2, 87.71 -53.49, -29.27 out-in out 10.315 Saltbr-in 3.152 HRD-in -82.62, -50.05 72.74, 0.25 in-in-in SNCiii in-in ActLoopNT-in 3.049 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.07, 135.76 APE9-dihe-na 113.27, -153.29 APE8-dihe-in -109.51, 129.79 APE8-rot-in 312.74 APE67-dihe-in -65.56, -15.72 -52.48, -42.69 APE12-dist-in 12.273 APE11-dist-in 12.386 APE10-dist-in 6.81 APE9-dist-in 3.76 None None None XRAY 2.2 0.239 0.264 B 338 314 0 0 0 0 [[12, 276]] 1.0 8y68 Homo sapiens CAMK_CASK_HUMAN CAMK 5.6e-82 280.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3TACA O14936 1 316 926.0 No_ligand No_ligand Pseudo DFGin 6.944 16.058 BLAminus -118.76, -153.24 70.18, 38.72 -82.45, 19.1 280.36, 87.78 -61.94, -22.6 in-in in 9.898 Saltbr-in 2.771 HRD-in -76.74, -44.98 69.76, -3.53 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.01, 154.44 APE9-dihe-na 104.4, -155.75 APE8-dihe-in -114.86, 120.22 APE8-rot-in 318.17 APE67-dihe-in -58.84, -21.43 -38.04, -53.6 APE12-dist-in 11.348 APE11-dist-in 11.992 APE10-dist-in 6.111 APE9-dist-in 3.89 None None None XRAY 2.2 0.197 0.236 A 361 316 0 0 0 0 [[12, 276]] 1.0 3tac Homo sapiens CAMK_CASK_HUMAN CAMK 6.9e-82 280.6 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3C0GA O14936 6 322 926.0 3AM:338 Type1 Pseudo DFGin 7.601 15.277 BLAminus -127.85, -156.96 71.55, 38.89 -83.99, 24.11 280.56, 90.68 -66.8, -16.25 in-in in 9.698 Saltbr-in 2.821 HRD-in -78.17, -49.52 75.88, -5.71 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.82, 145.93 APE9-dihe-na 104.74, -155.59 APE8-dihe-in -117.06, 121.65 APE8-rot-in 303.15 APE67-dihe-in -64.45, -28.84 -44.87, -37.97 APE12-dist-in 13.15 APE11-dist-in 12.427 APE10-dist-in 6.745 APE9-dist-in 3.762 None None None XRAY 2.19 0.211 0.27 A 351 309 0 0 0 0 [[12, 276]] 1.0 3c0g Homo sapiens CAMK_CASK_HUMAN CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3C0GB O14936 5 324 926.0 3AM:338 Type1 Pseudo DFGin 7.633 15.073 BLAminus -125.12, -156.54 71.61, 45.27 -92.39, 28.47 288.78, 82.4 -64.66, -24.35 in-in in 9.558 Saltbr-in 2.945 HRD-in -76.2, -51.0 76.77, -9.71 in-in-in SNCiii in-in ActLoopNT-in 3.007 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.55, 151.02 APE9-dihe-na 96.93, -151.24 APE8-dihe-in -120.05, 124.04 APE8-rot-in 309.17 APE67-dihe-in -64.19, -30.47 -45.02, -40.93 APE12-dist-in 12.971 APE11-dist-in 12.094 APE10-dist-in 6.525 APE9-dist-in 3.814 None None None XRAY 2.19 0.211 0.27 B 351 320 0 0 0 0 [[12, 276]] 1.0 3c0g Homo sapiens CAMK_CASK_HUMAN CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3C0IA O14936 6 303 926.0 3AM:338 Type1 Pseudo DFGin 7.764 15.227 BLAminus -126.8, -156.64 68.7, 42.73 -87.0, 18.63 278.58, 81.77 -64.01, -14.22 in-in in 9.672 Saltbr-in 2.605 HRD-in -80.62, -46.18 75.85, -2.66 in-in-in SNCiii in-in ActLoopNT-in 2.964 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.41, 154.48 APE9-dihe-na 101.89, -149.51 APE8-dihe-in -122.73, 125.07 APE8-rot-in 302.47 APE67-dihe-in -59.53, -20.3 -39.4, -52.94 APE12-dist-in 12.793 APE11-dist-in 12.642 APE10-dist-in 6.992 APE9-dist-in 3.661 None None None XRAY 1.85 0.185 0.234 A 351 298 0 0 0 0 [[12, 276]] 1.0 3c0i Homo sapiens CAMK_CASK_HUMAN CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAIA O14936 5 303 926.0 V5W:401 Type1 Pseudo DFGin 7.298 15.163 BLAminus -133.41, -156.01 67.4, 52.14 -90.27, 23.73 279.32, 78.06 -61.92, -24.84 in-in in 9.754 Saltbr-in 2.741 HRD-in -85.46, -50.33 75.77, -0.65 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.24, 157.29 APE9-dihe-na 101.8, -156.26 APE8-dihe-in -123.19, 124.54 APE8-rot-in 306.52 APE67-dihe-in -62.48, -18.0 -44.03, -47.72 APE12-dist-in 12.271 APE11-dist-in 12.237 APE10-dist-in 6.616 APE9-dist-in 3.487 None None None XRAY 2.3 0.181 0.213 A 353 299 0 0 0 0 [[12, 276]] 1.0 7oai Homo sapiens CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAIB O14936 5 303 926.0 V5W:401 Type1 Pseudo DFGin 7.406 15.259 BLAminus -134.47, -156.8 64.29, 54.6 -90.19, 20.71 279.7, 78.36 -59.98, -22.81 in-in in 9.646 Saltbr-in 2.755 HRD-in -82.86, -50.6 76.31, -2.1 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.62, 153.97 APE9-dihe-na 100.84, -154.73 APE8-dihe-in -124.35, 124.11 APE8-rot-in 306.98 APE67-dihe-in -62.09, -17.89 -45.97, -46.24 APE12-dist-in 12.157 APE11-dist-in 12.2 APE10-dist-in 6.647 APE9-dist-in 3.494 None None None XRAY 2.3 0.181 0.213 B 353 299 0 0 0 0 [[12, 276]] 1.0 7oai Homo sapiens CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAIC O14936 5 303 926.0 V5W:401 Type1 Pseudo DFGin 7.266 15.199 BLAminus -133.92, -155.83 67.09, 52.18 -89.16, 22.87 280.57, 76.97 -63.32, -23.32 in-in in 9.745 Saltbr-in 2.737 HRD-in -85.91, -50.13 74.59, 1.73 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.86, 156.71 APE9-dihe-na 102.05, -154.78 APE8-dihe-in -124.05, 124.49 APE8-rot-in 307.2 APE67-dihe-in -62.05, -18.61 -44.79, -47.86 APE12-dist-in 12.322 APE11-dist-in 12.242 APE10-dist-in 6.631 APE9-dist-in 3.478 None None None XRAY 2.3 0.181 0.213 C 353 299 0 0 0 0 [[12, 276]] 1.0 7oai Homo sapiens CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAID O14936 6 303 926.0 V5W:401 Type1 Pseudo DFGin 7.346 15.237 BLAminus -133.95, -155.79 64.33, 54.36 -89.82, 21.4 279.87, 77.78 -61.16, -23.41 in-in in 9.683 Saltbr-in 2.747 HRD-in -82.79, -50.35 76.19, -0.44 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.41, 155.17 APE9-dihe-na 102.2, -155.58 APE8-dihe-in -123.56, 124.71 APE8-rot-in 305.13 APE67-dihe-in -62.31, -17.38 -49.2, -45.27 APE12-dist-in 12.221 APE11-dist-in 12.209 APE10-dist-in 6.625 APE9-dist-in 3.501 None None None XRAY 2.3 0.181 0.213 D 353 298 0 0 0 0 [[12, 276]] 1.0 7oai Homo sapiens CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAJA O14936 6 303 926.0 V6E:401 Type1 Pseudo DFGin 7.465 15.078 BLAminus -137.38, -156.31 67.0, 54.02 -98.23, 24.47 280.92, 80.01 -59.79, -27.2 in-in in 9.591 Saltbr-in 2.708 HRD-in -81.0, -50.68 73.69, 2.52 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.23, 155.45 APE9-dihe-na 103.39, -156.39 APE8-dihe-in -113.61, 120.06 APE8-rot-in 307.44 APE67-dihe-in -63.71, -17.6 -41.22, -47.31 APE12-dist-in 12.54 APE11-dist-in 12.395 APE10-dist-in 6.658 APE9-dist-in 3.555 None None None XRAY 1.93 0.196 0.224 A 353 298 0 0 0 0 [[12, 276]] 1.0 7oaj Homo sapiens CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAJB O14936 6 302 926.0 V6E:401 Type1 Pseudo DFGin 7.475 15.079 BLAminus -137.94, -153.32 65.94, 55.26 -97.15, 23.72 281.55, 79.69 -61.84, -24.6 in-in in 9.72 Saltbr-in 2.724 HRD-in -77.62, -50.76 77.43, -1.23 in-in-in SNCiii in-in ActLoopNT-in 2.983 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.83, 154.2 APE9-dihe-na 101.54, -154.61 APE8-dihe-in -115.13, 119.42 APE8-rot-in 309.29 APE67-dihe-in -62.87, -17.76 -41.3, -48.63 APE12-dist-in 12.523 APE11-dist-in 12.327 APE10-dist-in 6.598 APE9-dist-in 3.578 None None None XRAY 1.93 0.196 0.224 B 353 297 0 0 0 0 [[12, 276]] 1.0 7oaj Homo sapiens CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAJC O14936 6 302 926.0 V6E:401 Type1 Pseudo DFGin 7.497 15.179 BLAminus -136.41, -160.63 72.01, 54.76 -99.05, 24.93 280.01, 78.43 -62.46, -24.7 in-in in 9.647 Saltbr-in 2.628 HRD-in -80.82, -50.61 76.79, -1.71 in-in-in SNCiii in-in ActLoopNT-in 2.97 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.6, 154.39 APE9-dihe-na 106.94, -159.9 APE8-dihe-in -112.12, 120.81 APE8-rot-in 308.21 APE67-dihe-in -62.82, -18.27 -42.55, -47.05 APE12-dist-in 12.485 APE11-dist-in 12.24 APE10-dist-in 6.525 APE9-dist-in 3.625 None None None XRAY 1.93 0.196 0.224 C 353 297 0 0 0 0 [[12, 276]] 1.0 7oaj Homo sapiens CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAJD O14936 6 302 926.0 V6E:401 Type1 Pseudo DFGin 7.454 15.113 BLAminus -138.17, -158.23 72.25, 54.22 -97.74, 24.82 282.66, 79.21 -59.78, -28.02 in-in in 9.571 Saltbr-in 2.708 HRD-in -80.07, -50.29 76.16, -3.37 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.41, 154.37 APE9-dihe-na 101.1, -156.72 APE8-dihe-in -114.39, 120.47 APE8-rot-in 308.84 APE67-dihe-in -63.16, -18.07 -42.13, -47.71 APE12-dist-in 12.304 APE11-dist-in 12.223 APE10-dist-in 6.557 APE9-dist-in 3.558 None None None XRAY 1.93 0.196 0.224 D 353 297 0 0 0 0 [[12, 276]] 1.0 7oaj Homo sapiens CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAKA O14936 6 303 926.0 V6B:401 Type1 Pseudo DFGin 7.304 15.228 BLAminus -130.41, -157.06 61.37, 61.32 -91.79, 25.13 281.33, 80.97 -69.94, -28.17 in-in in 9.527 Saltbr-in 2.841 HRD-in -76.13, -51.85 74.61, -3.02 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.67, 153.74 APE9-dihe-na 106.78, -159.33 APE8-dihe-in -112.37, 122.83 APE8-rot-in 314.55 APE67-dihe-in -61.67, -20.43 -41.39, -48.02 APE12-dist-in 12.319 APE11-dist-in 12.328 APE10-dist-in 6.584 APE9-dist-in 3.562 None None None XRAY 2.23 0.225 0.264 A 353 298 0 0 0 0 [[12, 276]] 1.0 7oak Homo sapiens CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAKB O14936 6 303 926.0 V6B:401 Type1 Pseudo DFGin 7.336 15.227 BLAminus -131.36, -157.62 62.2, 60.25 -91.91, 25.95 281.51, 81.91 -68.27, -29.14 in-in in 9.509 Saltbr-in 2.855 HRD-in -76.03, -51.92 74.46, -2.99 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.76, 153.77 APE9-dihe-na 102.84, -159.79 APE8-dihe-in -112.51, 123.0 APE8-rot-in 313.12 APE67-dihe-in -62.19, -20.22 -42.06, -47.29 APE12-dist-in 12.257 APE11-dist-in 12.353 APE10-dist-in 6.625 APE9-dist-in 3.57 None None None XRAY 2.23 0.225 0.264 B 353 298 0 0 0 0 [[12, 276]] 1.0 7oak Homo sapiens CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAKC O14936 6 303 926.0 V6B:401 Type1 Pseudo DFGin 7.434 15.302 BLAminus -132.96, -154.64 59.24, 62.07 -91.24, 25.15 282.78, 81.78 -68.83, -28.66 in-in in 9.561 Saltbr-in 2.832 HRD-in -74.19, -52.11 73.81, -2.72 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.28, 151.79 APE9-dihe-na 99.61, -159.19 APE8-dihe-in -113.41, 122.44 APE8-rot-in 312.66 APE67-dihe-in -61.94, -19.16 -40.72, -48.09 APE12-dist-in 11.971 APE11-dist-in 12.236 APE10-dist-in 6.56 APE9-dist-in 3.558 None None None XRAY 2.23 0.225 0.264 C 353 298 0 0 0 0 [[12, 276]] 1.0 7oak Homo sapiens CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OAKD O14936 6 303 926.0 V6B:401 Type1 Pseudo DFGin 7.447 15.292 BLAminus -131.94, -156.09 61.73, 60.92 -90.98, 25.56 282.18, 81.16 -70.77, -27.17 in-in in 9.524 Saltbr-in 2.901 HRD-in -74.78, -52.28 74.18, -3.89 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.98, 151.69 APE9-dihe-na 100.58, -159.38 APE8-dihe-in -113.19, 122.81 APE8-rot-in 313.65 APE67-dihe-in -62.13, -19.35 -40.85, -48.69 APE12-dist-in 11.978 APE11-dist-in 12.236 APE10-dist-in 6.558 APE9-dist-in 3.565 None None None XRAY 2.23 0.225 0.264 D 353 298 0 0 0 0 [[12, 276]] 1.0 7oak Homo sapiens CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OALA O14936 6 303 926.0 V62:401 Type1 Pseudo DFGin 7.112 15.312 BLAminus -132.36, -163.43 72.61, 55.26 -90.57, 19.61 279.99, 83.99 -61.09, -29.25 in-in in 9.583 Saltbr-in 2.875 HRD-in -85.81, -52.33 77.93, -1.53 in-in-in SNCiii in-in ActLoopNT-in 2.975 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.96, 152.07 APE9-dihe-na 101.6, -159.85 APE8-dihe-in -110.2, 121.48 APE8-rot-in 312.05 APE67-dihe-in -65.42, -19.22 -48.15, -43.67 APE12-dist-in 12.21 APE11-dist-in 12.253 APE10-dist-in 6.434 APE9-dist-in 3.666 None None None XRAY 2.17 0.223 0.274 A 353 298 0 0 0 0 [[12, 276]] 1.0 7oal Homo sapiens CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OALB O14936 6 303 926.0 V62:401 Type1 Pseudo DFGin 7.114 15.327 BLAminus -132.11, -163.12 72.34, 55.56 -91.3, 20.03 280.63, 83.48 -61.81, -28.8 in-in in 9.593 Saltbr-in 2.881 HRD-in -85.23, -52.63 77.44, -1.15 in-in-in SNCiii in-in ActLoopNT-in 2.978 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.35, 153.52 APE9-dihe-na 100.67, -161.1 APE8-dihe-in -109.69, 122.34 APE8-rot-in 310.81 APE67-dihe-in -65.02, -19.58 -48.89, -43.47 APE12-dist-in 12.242 APE11-dist-in 12.28 APE10-dist-in 6.451 APE9-dist-in 3.641 None None None XRAY 2.17 0.223 0.274 B 353 298 0 0 0 0 [[12, 276]] 1.0 7oal Homo sapiens CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OALC O14936 6 303 926.0 V62:401 Type1 Pseudo DFGin 7.316 15.302 BLAminus -133.03, -162.78 73.8, 55.36 -91.46, 20.34 280.91, 83.96 -61.1, -29.26 in-in in 9.501 Saltbr-in 2.866 HRD-in -82.75, -52.35 77.06, -0.71 in-in-in SNCiii in-in ActLoopNT-in 2.971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.29, 153.25 APE9-dihe-na 102.82, -161.36 APE8-dihe-in -109.75, 121.57 APE8-rot-in 312.81 APE67-dihe-in -65.06, -20.51 -46.72, -44.72 APE12-dist-in 12.1 APE11-dist-in 12.191 APE10-dist-in 6.382 APE9-dist-in 3.654 None None None XRAY 2.17 0.223 0.274 C 353 298 0 0 0 0 [[12, 276]] 1.0 7oal Homo sapiens CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 7OALD O14936 6 303 926.0 V62:401 Type1 Pseudo DFGin 7.274 15.233 BLAminus -132.5, -163.17 74.68, 55.23 -92.62, 20.5 281.05, 84.43 -61.57, -28.44 in-in in 9.515 Saltbr-in 2.886 HRD-in -83.05, -52.0 77.0, 0.16 in-in-in SNCiii in-in ActLoopNT-in 2.988 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.95, 153.91 APE9-dihe-na 103.44, -161.31 APE8-dihe-in -109.94, 121.75 APE8-rot-in 312.38 APE67-dihe-in -65.52, -20.47 -47.78, -43.72 APE12-dist-in 12.152 APE11-dist-in 12.238 APE10-dist-in 6.398 APE9-dist-in 3.67 None None None XRAY 2.17 0.223 0.274 D 353 298 0 0 0 0 [[12, 276]] 1.0 7oal Homo sapiens CAMK_CASK_HUMAN CAMK 6.4e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK STK40 STK40_HUMAN 5L2QA Q8N2I9 26 336 435.0 No_ligand No_ligand Pseudo DFGin 7.114 14.956 BLAminus -130.47, 179.73 54.86, 74.12 -97.26, 23.85 290.91, 75.33 -74.09, -21.88 in-in in 7.297 Saltbr-in 2.909 HRD-in -73.02, -40.2 65.84, 10.35 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.56, 165.42 APE9-dihe-na 143.21, -167.32 APE8-dihe-in -94.13, 140.21 APE8-rot-in 306.65 APE67-dihe-in -86.95, -21.7 -64.41, -20.42 APE12-dist-in 8.232 APE11-dist-in 11.512 APE10-dist-in 6.533 APE9-dist-in 4.186 None None None XRAY 2.53 0.259 0.28 A 320 293 18 0 0 0 [[35, 328]] 1.0 5l2q Homo sapiens CAMK_STK40_HUMAN CAMK 8.5e-56 195.3 3 252 250 215 216 217 219 221 66 93 97 194 196 195 197 256 243 238 237 236 235 234 233 232 142 Serine/threonine-protein kinase 40
CAMK STK40 STK40_HUMAN 5L2QB Q8N2I9 30 336 435.0 No_ligand No_ligand Pseudo DFGin 6.965 15.349 BLAminus -131.07, 171.22 59.14, 69.59 -85.39, 7.72 279.35, 77.7 -62.69, 161.76 in-none in 7.857 Saltbr-none 999.0 HRD-in -72.7, -41.34 64.76, 5.09 none-in-in SNCnii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.99, 164.94 APE9-dihe-na 135.93, -150.33 APE8-dihe-in -109.54, 129.83 APE8-rot-in 302.09 APE67-dihe-in -74.71, -21.69 -65.57, -29.17 APE12-dist-in 8.046 APE11-dist-in 11.887 APE10-dist-in 6.921 APE9-dist-in 4.563 None None None XRAY 2.53 0.259 0.28 B 320 282 25 0 0 0 [[35, 328]] 1.0 5l2q Homo sapiens CAMK_STK40_HUMAN CAMK 8.5e-56 195.3 3 252 250 215 216 217 219 221 66 93 97 194 196 195 197 256 243 238 237 236 235 234 233 232 142 Serine/threonine-protein kinase 40
CAMK STK40 STK40_HUMAN 5L2QC Q8N2I9 37 335 435.0 No_ligand No_ligand Pseudo DFGin 7.092 15.039 BLAminus -133.56, -179.23 57.51, 64.69 -82.37, 26.05 290.35, 86.47 -68.29, -15.59 in-in in 7.66 Saltbr-in 3.277 HRD-in -83.98, -44.38 69.36, 10.0 in-in-in SNCiii in-in ActLoopNT-in 3.066 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.34, 179.97 APE9-dihe-na 140.29, -163.44 APE8-dihe-in -109.8, 138.42 APE8-rot-in 300.31 APE67-dihe-in -73.67, -24.36 -69.64, -28.68 APE12-dist-in 7.088 APE11-dist-in 10.908 APE10-dist-in 6.356 APE9-dist-in 4.174 None None None XRAY 2.53 0.259 0.28 C 320 282 19 0 0 0 [[35, 328]] 1.0 5l2q Homo sapiens CAMK_STK40_HUMAN CAMK 8.5e-56 195.3 3 252 250 215 216 217 219 221 66 93 97 194 196 195 197 256 243 238 237 236 235 234 233 232 142 Serine/threonine-protein kinase 40
CAMK STK40 STK40_HUMAN 5L2QD Q8N2I9 30 336 435.0 No_ligand No_ligand Pseudo DFGin 7.252 16.006 BLAminus -120.21, 167.59 66.14, 61.69 -79.71, 21.58 270.92, 90.12 -59.45, 158.52 in-out in 8.082 Saltbr-out 3.644 HRD-in -71.64, -38.36 66.3, 3.21 out-in-out SNCoio in-out ActLoopNT-in 3.242 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -74.16, 173.54 APE9-dihe-na 143.3, -118.75 APE8-dihe-in -148.5, 125.34 APE8-rot-in 276.59 APE67-dihe-in -58.91, -57.22 -56.59, -40.18 APE12-dist-out 6.843 APE11-dist-in 11.068 APE10-dist-in 6.31 APE9-dist-in 4.288 None None None XRAY 2.53 0.259 0.28 D 320 294 13 0 0 0 [[35, 328]] 1.0 5l2q Homo sapiens CAMK_STK40_HUMAN CAMK 8.5e-56 195.3 3 252 250 215 216 217 219 221 66 93 97 194 196 195 197 256 243 238 237 236 235 234 233 232 142 Serine/threonine-protein kinase 40
CAMK TRIB1 TRIB1_HUMAN 6DC0A Q96RU8 90 67 372.0 No_ligand No_ligand Pseudo DFGin 5.27 13.715 ABAminus -62.79, -39.34 -158.25, 143.44 -106.23, 4.19 300.38, 172.91 -43.04, -40.92 in-na in 7.854 Saltbr-na 999.0 HRD-in -77.3, -49.83 85.96, -38.94 na-in-out SNCaio in-out ActLoopNT-in 2.808 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioi APE10-dihe-na -136.64, 136.29 APE9-dihe-na 165.89, 172.66 APE8-dihe-in -80.09, 127.29 APE8-rot-na 164.01 APE67-dihe-in -56.98, -28.22 -49.22, -44.47 APE12-dist-in 9.678 APE11-dist-in 13.949 APE10-dist-out 9.257 APE9-dist-in 5.005 None None None XRAY 2.8 0.223 0.277 A 292 252 0 0 0 0 [[99, 338]] 1.0 6dc0 Homo sapiens CAMK_TRIB1_HUMAN CAMK 1.3e-61 214.2 14 256 243 224 225 226 228 230 120 130 134 202 204 203 205 266 252 247 246 245 244 243 242 241 161 Tribbles homolog 1
CAMK TRIB1 TRIB1_HUMAN 6DC0B Q96RU8 90 74 372.0 No_ligand No_ligand Pseudo DFGin 5.352 13.828 ABAminus -62.01, -39.54 -159.17, 144.16 -104.11, 2.82 300.43, 173.55 -43.43, -39.53 in-na in 7.86 Saltbr-na 999.0 HRD-in -77.34, -49.74 84.82, -39.13 na-in-out SNCaio in-out ActLoopNT-in 2.806 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioi APE10-dihe-na -137.93, 136.24 APE9-dihe-na 164.23, 174.07 APE8-dihe-in -80.22, 127.97 APE8-rot-na 166.15 APE67-dihe-in -57.45, -28.66 -52.5, -42.66 APE12-dist-in 9.954 APE11-dist-in 13.924 APE10-dist-out 9.089 APE9-dist-in 4.988 None None None XRAY 2.8 0.223 0.277 B 292 249 4 0 0 0 [[99, 338]] 1.0 6dc0 Homo sapiens CAMK_TRIB1_HUMAN CAMK 1.3e-61 214.2 14 256 243 224 225 226 228 230 120 130 134 202 204 203 205 266 252 247 246 245 244 243 242 241 161 Tribbles homolog 1
CAMK TRIB1 TRIB1_HUMAN 5CEKA Q96RU8 88 342 372.0 No_ligand No_ligand Pseudo DFGinter 8.858 7.037 None -98.32, 87.14 -82.08, -7.36 -109.34, 16.03 300.0, 168.59 61.59, 55.88 out-na out 12.089 Saltbr-na 999.0 HRD-in -75.72, -58.41 87.17, -43.21 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 124.18 APE8-rot-na 59.79 APE67-dihe-out 80.81, -50.83 -77.85, -164.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.209 0.246 A 263 237 18 0 0 13 [[99, 338]] 1.0 5cek Homo sapiens CAMK_TRIB1_HUMAN CAMK 8.9e-62 214.7 14 256 243 224 225 226 228 230 120 130 134 202 204 203 205 266 252 247 246 245 244 243 242 241 161 Tribbles homolog 1
CAMK TRIB1 TRIB1_HUMAN 5CEMA Q96RU8 88 364 372.0 No_ligand No_ligand Pseudo DFGinter 9.487 6.83 None -85.06, 104.77 -111.16, 5.29 -105.21, 15.47 300.28, 1.5 60.7, 52.63 out-na out 12.027 Saltbr-na 999.0 HRD-in -82.52, -54.12 78.21, -13.8 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_oooo APE10-dihe-na -58.19, 148.96 APE9-dihe-na 66.07, 47.38 APE8-dihe-in -82.13, 123.37 APE8-rot-na 180.29 APE67-dihe-out -72.24, -16.3 -74.98, 72.26 APE12-dist-out 26.802 APE11-dist-out 24.692 APE10-dist-out 20.205 APE9-dist-out 15.941 None None None XRAY 2.1 0.179 0.223 A 292 252 11 0 0 9 [[99, 338]] 1.0 5cem Homo sapiens CAMK_TRIB1_HUMAN CAMK 1.3e-61 214.2 14 256 243 224 225 226 228 230 120 130 134 202 204 203 205 266 252 247 246 245 244 243 242 241 161 Tribbles homolog 1
CAMK TRIB2 TRIB2_HUMAN 7UPMA Q92519 55 312 343.0 No_ligand No_ligand Pseudo DFGin 4.905 14.44 ABAminus -58.01, -48.87 -164.7, 172.09 -114.04, 14.33 303.11, 167.65 -48.53, -44.56 in-na in 9.588 Saltbr-na 999.0 HRD-in -81.23, -42.97 77.99, -33.0 na-in-out SNCaio in-out ActLoopNT-in 2.874 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -129.77, 155.01 APE9-dihe-na 130.76, 152.14 APE8-dihe-in -71.56, 130.0 APE8-rot-na 194.78 APE67-dihe-in -65.79, -28.93 -44.49, -39.77 APE12-dist-in 12.62 APE11-dist-out 15.279 APE10-dist-out 9.734 APE9-dist-in 3.727 None None None XRAY 2.7 0.207 0.26 A 264 258 0 0 0 0 [[64, 308]] 1.0 7upm Homo sapiens CAMK_TRIB2_HUMAN CAMK 2.3e-61 213.3 14 256 243 194 195 196 198 200 90 100 104 172 174 173 175 236 222 217 216 215 214 213 212 211 131 Tribbles homolog 2
CAMK TTN TITIN_HUMAN 1TKIA Q8WZ42 32172 32492 34350.0 No_ligand No_ligand Pseudo DFGin 6.649 15.225 ABAminus -105.41, -5.26 -111.51, 126.72 -141.0, 22.89 293.99, 87.75 -67.88, -14.18 out-out out 11.004 Saltbr-out 4.917 HRD-in -83.05, -52.59 67.65, 9.17 out-in-out SNCoio in-out ActLoopNT-in 2.887 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioo APE10-dihe-na -163.08, 161.44 APE9-dihe-na -126.55, -21.86 APE8-dihe-in -112.32, 91.87 APE8-rot-none 999.0 APE67-dihe-in -57.33, -25.65 -56.87, -32.42 APE12-dist-in 7.36 APE11-dist-in 8.076 APE10-dist-out 10.434 APE9-dist-out 10.328 None None None XRAY 2.0 0.207 0.248 A 321 321 0 0 0 0 [[32178, 32432]] 1.0 1tki Homo sapiens CAMK_TTN_HUMAN CAMK 1.3e-78 270.0 1 256 256 32317 32318 32319 32321 32323 32207 32222 32226 32295 32297 32296 32298 32356 32344 32339 32338 32337 32336 32335 32334 32333 32252 Titin
CAMK TTN TITIN_HUMAN 1TKIB Q8WZ42 32172 32492 34350.0 No_ligand No_ligand Pseudo DFGin 6.648 15.22 ABAminus -105.18, -5.09 -111.75, 126.64 -140.7, 22.72 294.32, 87.47 -67.75, -13.65 out-out out 11.0 Saltbr-out 4.928 HRD-in -83.59, -52.58 67.17, 9.67 out-in-out SNCoio in-out ActLoopNT-in 2.888 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioo APE10-dihe-na -162.93, 161.49 APE9-dihe-na -126.47, -22.28 APE8-dihe-in -112.04, 92.34 APE8-rot-none 999.0 APE67-dihe-in -57.51, -25.32 -56.86, -32.43 APE12-dist-in 7.367 APE11-dist-in 8.079 APE10-dist-out 10.434 APE9-dist-out 10.324 None None None XRAY 2.0 0.207 0.248 B 321 321 0 0 0 0 [[32178, 32432]] 1.0 1tki Homo sapiens CAMK_TTN_HUMAN CAMK 1.3e-78 270.0 1 256 256 32317 32318 32319 32321 32323 32207 32222 32226 32295 32297 32296 32298 32356 32344 32339 32338 32337 32336 32335 32334 32333 32252 Titin
CAMK TTN TITIN_HUMAN 4JNWA Q8WZ42 32172 32491 34350.0 No_ligand No_ligand Pseudo DFGin 6.686 15.269 ABAminus -116.99, -2.14 -118.65, 122.2 -132.57, 18.41 290.09, 79.31 -63.31, -15.64 out-out out 10.849 Saltbr-out 4.793 HRD-in -91.99, -54.34 75.06, 8.93 out-in-out SNCoio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioo APE10-dihe-na -161.02, 157.09 APE9-dihe-na -117.92, -26.31 APE8-dihe-in -105.12, 102.28 APE8-rot-none 999.0 APE67-dihe-in -63.27, -22.9 -69.57, -21.96 APE12-dist-in 7.315 APE11-dist-in 8.022 APE10-dist-out 10.513 APE9-dist-out 10.349 None None None XRAY 2.06 0.167 0.204 A 324 320 0 0 0 0 [[32178, 32432]] 1.0 4jnw Homo sapiens CAMK_TTN_HUMAN CAMK 1.3e-78 270.0 1 256 256 32317 32318 32319 32321 32323 32207 32222 32226 32295 32297 32296 32298 32356 32344 32339 32338 32337 32336 32335 32334 32333 32252 Titin
CAMK TTN TITIN_HUMAN 4JNWB Q8WZ42 32172 32492 34350.0 No_ligand No_ligand Pseudo DFGin 6.749 15.292 ABAminus -118.57, -0.9 -117.06, 125.69 -137.2, 17.6 292.87, 80.6 -64.03, -12.11 out-out out 10.959 Saltbr-out 4.948 HRD-in -90.25, -54.84 76.1, 3.64 out-in-out SNCoio in-out ActLoopNT-in 2.994 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iooo APE10-dihe-na -158.84, 158.1 APE9-dihe-na -121.51, -17.99 APE8-dihe-in -112.0, 93.64 APE8-rot-none 999.0 APE67-dihe-in -62.34, -21.33 -67.09, -23.25 APE12-dist-in 7.495 APE11-dist-out 7.983 APE10-dist-out 10.521 APE9-dist-out 10.351 None None None XRAY 2.06 0.167 0.204 B 324 321 0 0 0 0 [[32178, 32432]] 1.0 4jnw Homo sapiens CAMK_TTN_HUMAN CAMK 1.3e-78 270.0 1 256 256 32317 32318 32319 32321 32323 32207 32222 32226 32295 32297 32296 32298 32356 32344 32339 32338 32337 32336 32335 32334 32333 32252 Titin
CAMK TTN TITIN_HUMAN 6YGNA Q8WZ42 32046 32594 34350.0 No_ligand No_ligand Pseudo DFGin 6.762 15.366 ABAminus -115.28, 1.72 -123.56, 124.55 -135.58, 21.33 288.63, 78.22 -67.2, -13.32 out-out out 11.067 Saltbr-out 4.825 HRD-in -88.18, -53.67 67.3, 21.18 out-in-out SNCoio in-out ActLoopNT-in 2.904 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioo APE10-dihe-na -156.84, 153.88 APE9-dihe-na -111.99, -16.7 APE8-dihe-in -110.46, 93.88 APE8-rot-none 999.0 APE67-dihe-in -62.26, -17.21 -67.36, -22.52 APE12-dist-in 7.69 APE11-dist-in 8.123 APE10-dist-out 10.452 APE9-dist-out 10.498 None None None XRAY 2.4 0.174 0.228 A 549 549 0 0 0 0 [[32178, 32432]] 1.0 6ygn Homo sapiens CAMK_TTN_HUMAN CAMK 5.9e-78 268.0 1 256 256 32317 32318 32319 32321 32323 32207 32222 32226 32295 32297 32296 32298 32356 32344 32339 32338 32337 32336 32335 32334 32333 32252 Titin
CAMK TTN TITIN_HUMAN 6YGNB Q8WZ42 32046 32594 34350.0 No_ligand No_ligand Pseudo DFGin 6.761 15.592 ABAminus -114.91, 3.5 -126.35, 122.2 -136.48, 21.32 287.83, 78.52 -68.05, -14.36 out-out out 11.206 Saltbr-out 5.008 HRD-in -92.6, -53.51 65.74, 20.58 out-in-out SNCoio in-out ActLoopNT-in 2.985 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioo APE10-dihe-na -159.78, 153.24 APE9-dihe-na -112.8, -17.54 APE8-dihe-in -108.31, 93.6 APE8-rot-none 999.0 APE67-dihe-in -63.95, -17.11 -65.81, -22.01 APE12-dist-in 7.884 APE11-dist-in 8.101 APE10-dist-out 10.509 APE9-dist-out 10.525 None None None XRAY 2.4 0.174 0.228 B 549 549 0 0 0 0 [[32178, 32432]] 1.0 6ygn Homo sapiens CAMK_TTN_HUMAN CAMK 5.9e-78 268.0 1 256 256 32317 32318 32319 32321 32323 32207 32222 32226 32295 32297 32296 32298 32356 32344 32339 32338 32337 32336 32335 32334 32333 32252 Titin
CK1 VRK3 VRK3_HUMAN 2JIIA Q8IV63 141 472 474.0 No_ligand No_ligand Pseudo DFGin 8.058 13.448 BLAminus -126.84, -158.76 59.27, 60.76 -88.16, 20.44 296.11, 92.21 -53.1, -27.84 in-in in 8.077 Saltbr-in 2.706 HRD-in -67.98, -48.21 89.48, -15.23 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -72.85, 117.18 APE9-dihe-na 111.48, -175.87 APE8-dihe-in -67.32, 115.98 APE8-rot-na 192.14 APE67-dihe-in -71.31, -23.63 -54.42, -32.09 APE12-dist-in 13.854 APE11-dist-in 12.424 APE10-dist-in 6.69 APE9-dist-in 4.861 None None None XRAY 2.0 0.181 0.223 A 352 321 11 0 0 0 [[166, 455]] 1.0 2jii Homo sapiens CK1_VRK3_HUMAN CK1 4.8e-96 327.1 1 261 261 325 326 327 329 331 203 214 218 303 305 304 306 372 360 355 354 353 352 351 350 349 260 Serine/threonine-protein kinase VRK3
CK1 VRK3 VRK3_HUMAN 2JIIB Q8IV63 138 472 474.0 No_ligand No_ligand Pseudo DFGin 7.972 13.62 BLAminus -126.23, -160.08 62.29, 57.97 -88.31, 21.29 296.85, 92.8 -56.12, -25.41 in-in in 8.204 Saltbr-in 2.738 HRD-in -68.53, -45.66 90.53, -18.15 in-in-in SNCiii in-in ActLoopNT-in 2.872 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -73.7, 114.01 APE9-dihe-na 113.19, -176.53 APE8-dihe-in -66.63, 117.55 APE8-rot-na 191.52 APE67-dihe-in -72.55, -20.81 -57.04, -32.6 APE12-dist-in 13.86 APE11-dist-in 12.368 APE10-dist-in 6.624 APE9-dist-in 4.974 None None None XRAY 2.0 0.181 0.223 B 352 325 10 0 0 0 [[166, 455]] 1.0 2jii Homo sapiens CK1_VRK3_HUMAN CK1 4.8e-96 327.1 1 261 261 325 326 327 329 331 203 214 218 303 305 304 306 372 360 355 354 353 352 351 350 349 260 Serine/threonine-protein kinase VRK3
OTHER MLKL MLKL_HUMAN 6O5ZA Q8NB16 191 470 471.0 No_ligand No_ligand Pseudo DFGin 5.443 14.318 BLAminus -137.01, -155.47 64.86, 62.95 -104.46, 17.08 308.51, 109.01 -69.75, 152.23 in-in in 8.314 Saltbr-in 2.576 HRD-na-E -62.32, -49.91 99.66, -25.44 in-out-out SNCioo out-out ActLoopNT-out 12.971 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -58.47, 131.06 APE9-dihe-na -68.43, 136.41 APE8-dihe-out -55.97, -34.58 APE8-rot-out 73.81 APE67-dihe-in -63.07, -19.3 -55.62, -29.72 APE12-dist-out 15.802 APE11-dist-out 20.901 APE10-dist-out 18.955 APE9-dist-out 13.509 None None None XRAY 2.285 0.188 0.232 A 287 271 9 0 0 9 [[204, 468]] 1.0 6o5z Homo sapiens OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 7JXUA Q8NB16 191 471 471.0 No_ligand No_ligand Pseudo DFGin 10.233 17.137 BLAplus -132.65, -169.61 81.08, 16.1 -134.12, -7.44 71.35, 105.39 -101.21, 148.73 out-out out 16.392 Saltbr-out 12.623 HRD-na-E -66.65, -47.96 95.71, -27.61 out-out-out SNCooo out-out ActLoopNT-out 12.645 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -121.95, 127.81 APE9-dihe-na -65.07, 143.96 APE8-dihe-out -61.15, -31.11 APE8-rot-out 55.57 APE67-dihe-in -65.35, -21.19 -55.84, -32.25 APE12-dist-out 20.752 APE11-dist-out 23.974 APE10-dist-out 23.051 APE9-dist-out 13.357 None None None XRAY 2.44 0.204 0.24 A 287 281 0 0 0 0 [[204, 468]] 1.0 7jxu Homo sapiens OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 7JXUB Q8NB16 191 471 471.0 No_ligand No_ligand Pseudo DFGin 10.316 17.087 BLAplus -140.29, -170.33 85.23, 13.17 -130.42, -22.22 65.36, 105.52 -88.31, 149.29 out-out out 16.023 Saltbr-out 12.194 HRD-na-E -66.79, -51.2 109.52, -44.96 out-out-out SNCooo out-out ActLoopNT-out 12.75 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -113.61, 128.79 APE9-dihe-na -66.68, 142.09 APE8-dihe-out -60.09, -31.37 APE8-rot-out 51.22 APE67-dihe-in -64.39, -17.94 -56.16, -31.14 APE12-dist-out 20.441 APE11-dist-out 23.536 APE10-dist-out 22.622 APE9-dist-out 13.679 None None None XRAY 2.44 0.204 0.24 B 287 281 0 0 0 0 [[204, 468]] 1.0 7jxu Homo sapiens OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 7MONA Q8NB16 191 469 471.0 ZL1:501 Type1 Pseudo DFGin 9.979 16.865 BLAplus -145.54, -169.15 78.1, 22.67 -139.07, -9.53 71.34, 104.02 -105.01, 150.93 out-out out 16.381 Saltbr-out 13.326 HRD-na-E -68.26, -49.99 100.84, -31.32 out-out-out SNCooo out-out ActLoopNT-out 12.642 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -104.91, 135.41 APE9-dihe-na -71.07, 134.23 APE8-dihe-out -64.44, -25.38 APE8-rot-out 60.07 APE67-dihe-in -61.51, -31.54 -61.49, -26.48 APE12-dist-out 19.855 APE11-dist-out 24.032 APE10-dist-out 23.012 APE9-dist-out 13.36 None None None XRAY 2.23 0.212 0.26 A 287 268 11 0 0 8 [[204, 468]] 1.0 7mon Homo sapiens OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 4MWIA Q8NB16 193 470 471.0 PXN:501 Allosteric Pseudo DFGin 5.101 14.027 BLBminus -145.19, 176.51 81.47, 24.62 -54.37, 137.54 316.54, 101.19 -155.24, 156.88 in-in in 8.284 Saltbr-in 2.785 HRD-na-E -64.85, -47.54 108.98, -24.83 in-out-out SNCioo out-out ActLoopNT-out 9.848 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -117.89, 131.59 APE9-dihe-na -66.57, 138.55 APE8-dihe-out -59.77, -32.75 APE8-rot-in 293.62 APE67-dihe-in -64.78, -27.84 -54.61, -33.19 APE12-dist-out 18.709 APE11-dist-out 22.428 APE10-dist-out 19.559 APE9-dist-out 13.893 None None None XRAY 1.7 0.166 0.194 A 294 266 12 0 0 12 [[204, 468]] 1.0 4mwi Homo sapiens OTHER_MLKL_HUMAN TKL 1.3e-50 178.3 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 6BWKA Q8NB16 192 470 471.0 No_ligand No_ligand Pseudo DFGin 5.543 14.506 BLBminus -134.48, -157.9 71.65, 72.71 -113.01, 128.24 304.19, 2.01 -171.84, 999.0 in-none in 8.32 Saltbr-none 999.0 HRD-na-E -70.14, -73.85 121.54, -3.94 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -50.44, -32.47 APE9-dihe-na -66.22, -37.06 APE8-dihe-out -125.32, 42.89 APE8-rot-in 304.11 APE67-dihe-in -60.02, -24.26 -42.43, -39.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.03 T357E,S358E None None XRAY 2.79 0.257 0.297 A 287 263 16 0 0 16 [[204, 468]] 1.0 6bwk Homo sapiens OTHER_MLKL_HUMAN TKL 7.6e-51 179.1 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 7JW7A Q8NB16 191 470 471.0 No_ligand No_ligand Pseudo DFGin 5.408 14.242 BLBminus -135.55, -168.18 79.35, 51.65 -93.92, 124.73 313.81, 102.38 -45.2, 999.0 in-in in 8.027 Saltbr-in 3.51 HRD-na-E -77.9, -36.2 97.95, -59.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, -51.94 APE9-dihe-na -65.12, 159.46 APE8-dihe-in -56.6, 134.48 APE8-rot-out 181.21 APE67-dihe-in -63.92, -31.38 -109.1, 12.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.171 None None None XRAY 2.63 0.23 0.281 A 287 256 24 0 0 19 [[204, 468]] 1.0 7jw7 Homo sapiens OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 8SLZA Q8NB16 191 469 471.0 No_ligand No_ligand Pseudo DFGin 5.233 14.227 BLBminus -150.61, -167.39 68.99, 34.67 -68.29, 133.66 314.13, 95.49 -158.29, 157.94 in-in in 8.235 Saltbr-in 3.271 HRD-na-E -67.15, -50.86 111.36, -33.45 in-out-out SNCioo out-out ActLoopNT-out 10.041 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -117.52, 132.52 APE9-dihe-na -65.28, 139.38 APE8-dihe-out -65.39, -23.86 APE8-rot-out 181.55 APE67-dihe-in -69.04, -23.74 -66.59, -23.09 APE12-dist-out 21.373 APE11-dist-out 21.61 APE10-dist-out 19.417 APE9-dist-out 14.106 None TPO357,SEP358 TPO357,SEP358 XRAY 2.3 0.204 0.234 A 287 265 14 0 0 14 [[204, 468]] 1.0 8slz Homo sapiens OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 4M67A Q8NB16 192 469 471.0 No_ligand No_ligand Pseudo DFGin 5.135 14.327 BLBminus -139.33, 178.33 78.86, 30.59 -63.54, 143.02 316.28, 95.46 -163.25, 152.36 in-in in 8.294 Saltbr-in 2.87 HRD-na-E -69.35, -45.81 105.49, -24.9 in-out-out SNCioo out-out ActLoopNT-out 9.945 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -114.78, 129.69 APE9-dihe-na -64.48, 137.26 APE8-dihe-out -54.3, -46.25 APE8-rot-out 173.11 APE67-dihe-in -60.1, -29.27 -51.47, -31.0 APE12-dist-out 20.382 APE11-dist-out 22.459 APE10-dist-out 19.663 APE9-dist-out 14.217 None None None XRAY 1.9 0.206 0.225 A 293 264 14 0 0 14 [[204, 468]] 1.0 4m67 Homo sapiens OTHER_MLKL_HUMAN TKL 1.3e-50 178.3 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 6LK6A Q8NB16 192 470 471.0 No_ligand No_ligand Pseudo DFGin 5.213 14.238 BLBminus -140.9, -170.14 65.42, 43.61 -73.62, 139.5 313.43, 104.69 -170.25, 149.43 in-in in 8.334 Saltbr-in 2.996 HRD-na-E -65.81, -51.34 97.84, -20.78 in-out-out SNCioo out-out ActLoopNT-out 9.808 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -101.65, 139.93 APE9-dihe-na -76.17, 137.87 APE8-dihe-out -56.28, -33.41 APE8-rot-out 70.42 APE67-dihe-in -50.97, -36.19 -56.07, -45.36 APE12-dist-out 19.515 APE11-dist-out 22.474 APE10-dist-out 19.881 APE9-dist-out 13.826 T357A,S358A None None XRAY 2.41 0.211 0.247 A 293 265 14 0 0 14 [[204, 468]] 1.0 6lk6 Homo sapiens OTHER_MLKL_HUMAN TKL 2.7e-50 177.3 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 6LK5A Q8NB16 192 470 471.0 No_ligand No_ligand Pseudo DFGin 5.11 14.286 BLBminus -141.79, -176.2 75.53, 28.55 -58.2, 124.61 313.01, 96.64 -149.56, 158.33 in-in in 8.237 Saltbr-in 3.182 HRD-na-E -64.32, -47.98 104.12, -32.13 in-out-out SNCioo out-out ActLoopNT-out 9.936 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -108.35, 134.78 APE9-dihe-na -64.51, 142.03 APE8-dihe-out -60.77, -31.01 APE8-rot-out 173.43 APE67-dihe-in -57.88, -30.62 -62.19, -38.79 APE12-dist-out 18.924 APE11-dist-out 22.425 APE10-dist-out 19.628 APE9-dist-out 13.871 T357E,S358D None None XRAY 2.5 0.196 0.238 A 471 265 14 0 0 14 [[204, 468]] 1.0 6lk5 Homo sapiens OTHER_MLKL_HUMAN TKL 4e-50 177.2 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 5KO1A Q8NB16 192 470 471.0 6UY:501 Type1 Pseudo DFGin 4.808 14.578 BLBminus -140.42, -174.32 76.63, 35.3 -54.73, 138.73 314.86, 105.28 -152.71, 153.41 in-in in 8.458 Saltbr-in 2.748 HRD-na-E -68.56, -45.64 105.05, -24.44 in-out-out SNCioo out-out ActLoopNT-out 10.017 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -113.74, 135.2 APE9-dihe-na -68.0, 131.39 APE8-dihe-out -57.71, -40.85 APE8-rot-in 266.07 APE67-dihe-in -60.07, -28.3 -49.24, -31.82 APE12-dist-out 19.02 APE11-dist-out 22.517 APE10-dist-out 19.51 APE9-dist-out 14.173 E366A,K367A None None XRAY 2.16 0.19 0.226 A 283 265 14 0 0 14 [[204, 468]] 1.0 5ko1 Homo sapiens OTHER_MLKL_HUMAN TKL 5.2e-50 176.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 6O5ZB Q8NB16 190 467 471.0 LN4:501 Type2 Pseudo DFGout 14.831 7.098 None -138.35, -166.14 -159.95, 69.78 -102.91, 999.0 194.77, 99.88 999.0, 999.0 in-out in 8.184 Saltbr-out 3.829 HRD-na-E -64.26, -51.93 98.68, -26.13 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -59.03, 132.55 APE9-dihe-na -64.81, 136.14 APE8-dihe-out -54.72, -38.12 APE8-rot-in 307.78 APE67-dihe-in -62.93, -23.04 -55.72, -31.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.392 None None None XRAY 2.285 0.188 0.232 B 287 260 19 0 0 12 [[204, 468]] 1.0 6o5z Homo sapiens OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 5KNJA Q8NB16 193 468 471.0 6UX:501 Type1 Pseudo None 999.0 999.0 None -135.25, 171.18 -163.91, 150.5 -79.14, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.182 Saltbr-in 2.806 HRD-na-E -70.33, -43.91 105.29, -17.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -112.22, 131.74 APE9-dihe-na -62.16, 135.85 APE8-dihe-out -59.27, -43.82 APE8-rot-in 300.34 APE67-dihe-in -57.77, -31.82 -42.79, -35.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.573 E366A,K367A None None XRAY 2.88 0.196 0.256 A 283 252 24 0 0 18 [[204, 468]] 1.0 5knj Homo sapiens OTHER_MLKL_HUMAN TKL 5.2e-50 176.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 5KNJB Q8NB16 192 469 471.0 6UX:501 Type1 Pseudo None 999.0 999.0 None -136.96, 165.94 -88.72, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.092 Saltbr-in 2.838 HRD-na-E -70.61, -44.28 104.64, -17.59 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -135.3, 131.22 APE9-dihe-na -64.5, 137.16 APE8-dihe-out -52.4, -47.35 APE8-rot-in 302.78 APE67-dihe-in -59.21, -30.37 -42.44, -36.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.867 E366A,K367A None None XRAY 2.88 0.196 0.256 B 283 259 19 0 0 19 [[204, 468]] 1.0 5knj Homo sapiens OTHER_MLKL_HUMAN TKL 5.2e-50 176.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER PAN3 PAN3_HUMAN 9QTUA Q58A45 470 887 887.0 No_ligand No_ligand Pseudo DFGin 7.629 12.618 BLBminus -129.14, 168.31 55.8, 57.39 -86.82, 126.91 289.05, 999.0 84.49, -7.45 out-na out 16.938 Saltbr-na 999.0 HRD-in -70.23, -48.45 52.51, 26.26 na-out-na SNCaoa out-na ActLoopNT-out 6.726 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -59.17, 133.94 APE9-dihe-na -139.77, 155.63 APE8-dihe-na -106.23, 3.84 APE8-rot-na 207.6 APE67-dihe-na -83.45, 50.15 -63.24, -21.41 APE12-dist-na 5.615 APE11-dist-na 8.587 APE10-dist-na 9.043 APE9-dist-na 15.452 None None None EM 4.6 999.0 999.0 A 863 418 0 0 0 0 [[472, 759]] 1.0 9qtu Homo sapiens OTHER_PAN3_HUMAN PAN3 3.5e-175 587.1 1 288 288 657 658 659 661 663 521 536 540 637 639 638 640 686 676 671 670 669 668 667 666 665 570 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_HUMAN 9QTUB Q58A45 470 887 887.0 No_ligand No_ligand Pseudo DFGin 8.263 12.02 BLBminus -100.76, 176.11 56.23, 61.14 -97.32, 152.4 308.88, 999.0 53.22, 50.35 out-na out 16.294 Saltbr-na 999.0 HRD-in -72.51, -40.23 43.56, 28.97 na-out-na SNCaoa out-na ActLoopNT-out 7.368 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -88.38, 114.43 APE9-dihe-na -132.3, 150.78 APE8-dihe-na -89.72, 17.82 APE8-rot-na 302.92 APE67-dihe-na -83.3, 51.22 -62.52, -39.08 APE12-dist-na 5.216 APE11-dist-na 8.336 APE10-dist-na 9.036 APE9-dist-na 16.012 None None None EM 4.6 999.0 999.0 B 863 418 0 0 0 0 [[472, 759]] 1.0 9qtu Homo sapiens OTHER_PAN3_HUMAN PAN3 3.5e-175 587.1 1 288 288 657 658 659 661 663 521 536 540 637 639 638 640 686 676 671 670 669 668 667 666 665 570 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PEAK1 PEAK1_HUMAN 6BHCA Q9H792 1285 1743 1746.0 No_ligand No_ligand Pseudo DFGin 5.695 15.242 BLAminus -137.03, -177.55 61.13, 81.47 -100.07, 34.54 288.4, 76.8 -70.97, -28.29 out-na out 10.366 Saltbr-na 999.0 HRD-in -68.45, -48.56 69.76, 5.84 na-in-out SNCaio in-out ActLoopNT-in 2.957 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -102.07 APE8-dihe-out -85.98, -28.63 APE8-rot-na 192.98 APE67-dihe-in -67.0, -16.19 -77.03, -7.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.508 S1542T None None XRAY 2.3 0.196 0.234 A 438 370 43 0 0 9 [[1319, 1673]] 1.0 6bhc Homo sapiens OTHER_PEAK1_HUMAN PEAK 6.7e-47 571.2 1 94 322 1554 1555 1556 1558 1560 1359 1374 1378 1513 1515 1514 1516 1591 1580 1575 1574 1573 1572 1571 1570 1569 1464 Inactive tyrosine-protein kinase PEAK1
OTHER PIK3R4 PI3R4_HUMAN 8SORA Q99570 15 1358 1358.0 ADP:1401 ATPlike Pseudo DFGin 9.418 15.81 BLBminus -148.68, -163.36 56.86, 40.25 -54.73, 139.1 286.63, 79.79 -95.49, 38.09 out-out out 17.808 Saltbr-out 21.09 HRD-in -78.26, -64.21 93.22, -18.74 out-out-out SNCooo out-out ActLoopNT-out 9.121 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na 53.41, 44.04 APE9-dihe-na -115.24, -10.88 APE8-dihe-out 68.3, 15.78 APE8-rot-na 299.15 APE67-dihe-out -125.94, 101.57 -74.9, 135.12 APE12-dist-out 14.302 APE11-dist-out 17.974 APE10-dist-out 21.055 APE9-dist-out 15.977 None None None EM 3.96 999.0 999.0 A 1358 1156 28 0 0 0 [[19, 321]] 1.0 8sor Homo sapiens OTHER_PIK3R4_HUMAN PIK3R4 5.8e-151 507.9 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 9MHFA Q99570 14 1358 1358.0 No_ligand No_ligand Pseudo DFGin 9.316 15.926 BLBminus -137.15, 164.9 65.91, 49.84 -57.2, 122.9 277.63, 71.86 -84.62, 59.4 out-out out 18.109 Saltbr-out 17.236 HRD-out -96.05, 90.63 -67.78, 11.21 out-out-out SNCooo out-out ActLoopNT-out 9.113 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na 62.11, 44.99 APE9-dihe-na -103.33, -9.73 APE8-dihe-out 66.79, 8.06 APE8-rot-na 292.08 APE67-dihe-out -138.42, 103.87 -64.74, 143.63 APE12-dist-out 14.437 APE11-dist-out 18.408 APE10-dist-out 20.977 APE9-dist-out 15.949 None None None EM 2.73 999.0 999.0 A 1409 1179 27 0 0 0 [[19, 321]] 1.0 9mhf Homo sapiens OTHER_PIK3R4_HUMAN PIK3R4 6.2e-151 507.8 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 9MHGA Q99570 2 1358 1358.0 No_ligand No_ligand Pseudo DFGin 9.585 16.209 BLBminus -138.69, 173.76 59.25, 52.03 -58.14, 130.77 283.01, 77.56 -95.81, 48.2 out-out out 18.272 Saltbr-out 21.234 HRD-in -80.12, -61.33 90.81, -7.5 out-out-out SNCooo out-out ActLoopNT-out 9.246 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na 54.37, 16.6 APE9-dihe-na -78.09, -5.34 APE8-dihe-out 69.83, -1.25 APE8-rot-na 218.72 APE67-dihe-out -116.55, 112.58 -66.54, 126.46 APE12-dist-out 14.093 APE11-dist-out 17.864 APE10-dist-out 20.978 APE9-dist-out 15.65 None None None EM 3.2 999.0 999.0 A 1409 1188 19 0 0 0 [[19, 321]] 1.0 9mhg Homo sapiens OTHER_PIK3R4_HUMAN PIK3R4 6.2e-151 507.8 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 9C82A Q99570 64 1358 1358.0 No_ligand No_ligand Pseudo None 999.0 999.0 None -164.16, -177.07 55.57, 42.13 -52.45, 120.86 999.0, 999.0 -77.68, 59.73 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.24, -54.58 79.91, -42.88 none-out-out SNCnoo out-out ActLoopNT-out 8.339 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na 78.23, -5.89 APE9-dihe-na -85.52, -1.85 APE8-dihe-out 57.79, 25.3 APE8-rot-none 999.0 APE67-dihe-out -115.98, 93.47 -52.79, 127.92 APE12-dist-out 15.521 APE11-dist-out 19.431 APE10-dist-out 22.667 APE9-dist-out 16.035 None None None EM 6.84 999.0 999.0 A 1358 1038 84 0 0 0 [[19, 321]] 1.0 9c82 Homo sapiens OTHER_PIK3R4_HUMAN PIK3R4 5.8e-151 507.9 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 7BL1CCC Q99570 12 1358 1358.0 No_ligand No_ligand Pseudo None 999.0 999.0 None -76.88, 121.2 -97.88, -157.84 -133.25, 23.54 999.0, 999.0 -119.58, 76.53 out-none out 19.336 Saltbr-none 999.0 HRD-out -62.71, 162.59 74.35, 11.28 none-out-out SNCnoo out-out ActLoopNT-out 17.743 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na -137.26, 20.08 APE9-dihe-na -166.34, -173.1 APE8-dihe-out -69.07, -7.2 APE8-rot-none 999.0 APE67-dihe-out -53.52, 153.93 -148.29, -158.16 APE12-dist-out 15.718 APE11-dist-out 15.611 APE10-dist-out 15.777 APE9-dist-out 18.72 None None None EM 9.8 0.157 999.0 CCC 1371 1189 0 0 0 0 [[19, 321]] 1.0 7bl1 Homo sapiens OTHER_PIK3R4_HUMAN PIK3R4 5.9e-151 507.9 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 9MHHA Q99570 16 1358 1358.0 No_ligand No_ligand Pseudo None 999.0 999.0 None -128.48, 178.68 62.02, 54.05 -67.58, 106.95 999.0, 999.0 -108.31, 61.96 none-none none 999.0 Saltbr-none 999.0 HRD-in -78.85, -55.76 81.49, -5.71 none-out-out SNCnoo out-out ActLoopNT-out 9.548 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na 57.34, 14.48 APE9-dihe-na -81.14, -9.46 APE8-dihe-out 59.93, 19.07 APE8-rot-none 999.0 APE67-dihe-out -125.77, 107.65 -89.25, 132.69 APE12-dist-out 15.001 APE11-dist-out 17.495 APE10-dist-out 20.139 APE9-dist-out 15.78 None None None EM 4.5 999.0 999.0 A 1409 1191 19 0 0 0 [[19, 321]] 1.0 9mhh Homo sapiens OTHER_PIK3R4_HUMAN PIK3R4 6.2e-151 507.8 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PRAG1 PRAG1_HUMAN 5VE6A Q86YV5 944 1405 1406.0 No_ligand No_ligand Pseudo None 999.0 15.913 None -72.21, 156.31 -91.78, 163.14 -113.76, 999.0 51.93, 89.28 999.0, 999.0 none-na none 999.0 Saltbr-na 999.0 HRD-out -76.41, 103.68 -60.03, -25.85 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.953 0.222 0.262 A 492 348 95 0 0 21 [[984, 1335]] 1.0 5ve6 Homo sapiens OTHER_PRAG1_HUMAN PEAK 1.1e-148 503.5 1 349 349 1215 1216 1217 1219 1221 1024 1034 1038 1142 1144 1143 1145 1253 1242 1237 1236 1235 1234 1233 1232 1231 1093 Inactive tyrosine-protein kinase PRAG1
OTHER RNASEL RN5A_HUMAN 4OAUC Q05823 25 719 741.0 ADP:801 ATPlike Pseudo DFGin 6.529 12.379 BLAminus -152.72, -178.03 59.98, 103.61 -125.32, 12.02 305.12, 98.0 -75.28, 8.76 in-in in 6.993 Saltbr-in 2.623 HRD-in -74.91, -47.94 67.23, 8.17 in-in-na SNCiia in-na ActLoopNT-in 2.913 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -67.73, 111.98 APE9-dihe-na -66.2, -20.72 APE8-dihe-na -68.67, -28.85 APE8-rot-na 187.68 APE67-dihe-na -72.58, -38.81 -76.25, -36.54 APE12-dist-na 14.068 APE11-dist-na 16.875 APE10-dist-na 14.985 APE9-dist-na 14.333 H672N None None XRAY 2.6 0.213 0.251 C 699 692 0 0 0 0 [[353, 594]] 1.0 4oau Homo sapiens OTHER_RNASEL_HUMAN RNASEL 4.1e-136 459.9 1 242 242 502 503 504 506 508 392 404 408 482 484 483 485 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
OTHER RNASEL RN5A_HUMAN 4OAVB Q05823 24 717 741.0 ACP:801 ATPlike Pseudo DFGin 6.475 12.367 BLAminus -139.92, -178.5 65.74, 91.26 -114.98, 14.68 309.18, 101.1 -77.21, 3.69 in-in in 6.905 Saltbr-in 2.74 HRD-in -87.38, -45.25 69.13, -2.14 in-in-na SNCiia in-na ActLoopNT-in 3.06 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.56, 102.63 APE9-dihe-na -56.52, -19.13 APE8-dihe-na -66.25, -31.04 APE8-rot-na 198.81 APE67-dihe-na -66.21, -44.37 -71.69, -39.0 APE12-dist-na 15.293 APE11-dist-na 17.012 APE10-dist-na 15.02 APE9-dist-na 14.396 H672N None None XRAY 2.1 0.2 0.229 B 699 673 8 0 0 0 [[353, 594]] 1.0 4oav Homo sapiens OTHER_RNASEL_HUMAN RNASEL 4.1e-136 459.9 1 242 242 502 503 504 506 508 392 404 408 482 484 483 485 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
OTHER RNASEL RN5A_HUMAN 4OAVD Q05823 26 719 741.0 ACP:1001 ATPlike Pseudo DFGin 6.559 12.405 BLAminus -138.71, -178.08 64.72, 95.25 -118.8, 14.99 306.98, 96.56 -77.32, 4.45 in-in in 6.904 Saltbr-in 2.919 HRD-in -73.82, -49.38 73.22, -2.68 in-in-na SNCiia in-na ActLoopNT-in 2.915 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.59, 112.49 APE9-dihe-na -62.01, -29.18 APE8-dihe-na -62.89, -32.55 APE8-rot-na 188.49 APE67-dihe-na -70.07, -38.9 -67.42, -39.34 APE12-dist-na 14.651 APE11-dist-na 16.869 APE10-dist-na 14.635 APE9-dist-na 14.352 H672N None None XRAY 2.1 0.2 0.229 D 699 674 7 0 0 0 [[353, 594]] 1.0 4oav Homo sapiens OTHER_RNASEL_HUMAN RNASEL 4.1e-136 459.9 1 242 242 502 503 504 506 508 392 404 408 482 484 483 485 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
OTHER ULK4 ULK4_HUMAN 6TSZU Q96C45 2 285 1275.0 AGS:60301 ATPlike Pseudo DFGin 6.37 18.271 ABAminus -125.81, 9.4 -156.01, 117.6 -115.95, 19.15 288.81, 81.65 -56.0, -43.19 out-na out 14.288 Saltbr-na 999.0 HRD-in -78.74, -35.33 74.51, -30.17 na-in-out SNCaio in-out ActLoopNT-in 2.748 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -74.27, 133.36 APE9-dihe-na -108.57, -165.46 APE8-dihe-in -71.23, 118.04 APE8-rot-in 324.52 APE67-dihe-in -65.15, -30.07 -62.89, -23.31 APE12-dist-in 8.579 APE11-dist-out 6.171 APE10-dist-out 9.182 APE9-dist-in 5.697 None None None XRAY 1.9 0.203 0.253 U 305 283 1 0 0 1 [[4, 280]] 1.0 6tsz Homo sapiens OTHER_ULK4_HUMAN ULK 1.2e-118 401.1 1 256 256 138 139 140 142 144 34 46 50 118 120 119 121 201 189 184 183 182 181 180 179 178 76 Serine/threonine-protein kinase ULK4
OTHER ULK4 ULK4_HUMAN 6U5LA Q96C45 1 285 1275.0 3RJ:60301 Type1 Pseudo DFGin 6.226 18.455 ABAminus -136.12, 15.31 -157.37, 109.67 -112.82, 20.67 287.68, 79.1 -55.24, -38.19 out-na out 13.962 Saltbr-na 999.0 HRD-in -80.42, -35.75 72.37, -25.3 na-in-out SNCaio in-out ActLoopNT-in 2.715 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -90.65, 119.09 APE9-dihe-na -89.22, -142.79 APE8-dihe-in -86.05, 132.82 APE8-rot-out 161.95 APE67-dihe-in -66.84, -35.55 -76.04, -11.61 APE12-dist-in 8.948 APE11-dist-out 6.328 APE10-dist-out 9.158 APE9-dist-in 5.993 K172A,K173A None None XRAY 1.75 0.192 0.216 A 287 274 11 0 0 11 [[4, 280]] 1.0 6u5l Homo sapiens OTHER_ULK4_HUMAN ULK 9.2e-119 401.4 1 256 256 138 139 140 142 144 34 46 50 118 120 119 121 201 189 184 183 182 181 180 179 178 76 Serine/threonine-protein kinase ULK4
RGC GUCY2C GUC2C_HUMAN 8FX4D P25092 550 755 1073.0 No_ligand No_ligand Pseudo None 999.0 999.0 None -103.03, -170.69 -90.03, -54.6 59.24, -64.74 158.72, 66.25 -58.61, -37.07 none-none none 999.0 Saltbr-none 999.0 HRD-in -94.68, -61.25 97.05, -18.95 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iioo APE10-dihe-na -89.56, 18.63 APE9-dihe-na -68.85, 85.4 APE8-dihe-in -65.22, 138.25 APE8-rot-na 189.13 APE67-dihe-out -65.39, -17.44 -155.76, 166.0 APE12-dist-in 12.911 APE11-dist-in 10.113 APE10-dist-out 15.685 APE9-dist-out 10.567 None None None EM 3.9 999.0 999.0 D 741 203 64 0 0 3 [[489, 747]] 1.0 8fx4 Homo sapiens RGC_GUCY2C_HUMAN RGC 3.4e-106 361.1 2 265 264 631 632 633 635 637 516 532 536 611 613 612 614 662 650 645 644 643 642 641 640 639 562 Guanylyl cyclase C
RGC NPR1 ANPRA_HUMAN 9BCOA P16066 498 1053 1061.0 ATP:61101 ATPlike Pseudo DFGin 6.5 14.828 BLBplus -89.25, -164.06 42.72, 55.71 -135.24, 156.32 73.6, 95.91 78.22, -166.07 out-none out 16.928 Saltbr-none 999.0 HRD-out -74.2, 156.17 -59.96, -57.76 none-out-out SNCnoo out-out ActLoopNT-out 12.014 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -68.12, -1.53 APE9-dihe-na -60.93, -51.9 APE8-dihe-in -129.45, 85.23 APE8-rot-none 999.0 APE67-dihe-in -58.29, -38.75 -145.34, 13.28 APE12-dist-out 23.574 APE11-dist-out 20.43 APE10-dist-out 24.55 APE9-dist-out 15.858 None None None EM 4.4 999.0 999.0 A 1040 521 21 0 0 0 [[539, 803]] 1.0 9bco Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCOB P16066 501 1053 1061.0 ATP:61101 ATPlike Pseudo DFGin 6.035 14.05 BLBplus -88.95, 166.99 56.44, 21.66 -61.11, 145.38 64.96, 87.18 86.53, -116.67 out-none out 15.454 Saltbr-none 999.0 HRD-in -114.17, -53.78 98.92, -43.57 none-out-out SNCnoo out-out ActLoopNT-out 9.447 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -52.94, -51.71 APE9-dihe-na -111.55, -27.36 APE8-dihe-out -110.69, 11.24 APE8-rot-none 999.0 APE67-dihe-in -47.42, -35.74 -121.93, -1.95 APE12-dist-out 18.204 APE11-dist-out 21.211 APE10-dist-out 24.218 APE9-dist-out 14.706 None None None EM 4.4 999.0 999.0 B 1040 517 22 0 0 0 [[539, 803]] 1.0 9bco Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCPA P16066 505 842 1061.0 ATP:61101 ATPlike Pseudo DFGin 5.276 13.499 BLBplus -119.01, 147.56 55.81, 47.24 -98.35, -175.13 72.56, 101.5 63.71, -113.08 out-none out 15.017 Saltbr-none 999.0 HRD-in -101.28, -53.45 85.86, -1.89 none-out-out SNCnoo out-out ActLoopNT-out 10.061 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -56.32, -46.22 APE9-dihe-na -56.3, -35.86 APE8-dihe-out -106.06, -11.55 APE8-rot-na 74.77 APE67-dihe-in -55.12, -26.01 -77.38, -2.19 APE12-dist-out 20.65 APE11-dist-out 18.471 APE10-dist-out 23.005 APE9-dist-out 14.329 None None None EM 4.1 999.0 999.0 A 1040 314 21 0 0 0 [[539, 803]] 1.0 9bcp Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCPB P16066 503 841 1061.0 ATP:61101 ATPlike Pseudo DFGin 5.356 16.761 BLBtrans -138.66, -167.01 55.46, 41.07 -76.35, 89.03 193.7, 109.94 60.64, -128.0 out-none out 16.649 Saltbr-none 999.0 HRD-out -58.73, 127.47 -87.85, -41.33 none-out-out SNCnoo out-out ActLoopNT-out 12.183 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na -63.64, -13.04 APE9-dihe-na -73.26, -45.78 APE8-dihe-out -94.47, 23.47 APE8-rot-na 181.32 APE67-dihe-out -126.85, -50.61 -149.46, 92.68 APE12-dist-out 22.361 APE11-dist-out 19.678 APE10-dist-out 23.708 APE9-dist-out 15.401 None None None EM 4.1 999.0 999.0 B 1040 304 21 0 0 0 [[539, 803]] 1.0 9bcp Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCSA P16066 503 1055 1061.0 ATP:61100 ATPlike Pseudo DFGin 7.694 15.737 None -74.51, -65.19 38.98, 36.73 -149.34, 137.28 313.08, 80.76 -109.19, -24.55 out-none out 17.336 Saltbr-none 999.0 HRD-in -67.46, -13.34 80.4, -46.04 none-out-out SNCnoo out-out ActLoopNT-out 11.453 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -59.39, -44.12 APE9-dihe-na -70.77, -47.95 APE8-dihe-out -62.03, -25.18 APE8-rot-na 74.24 APE67-dihe-in -57.49, -15.22 -74.7, -41.95 APE12-dist-out 24.021 APE11-dist-out 19.76 APE10-dist-out 23.161 APE9-dist-out 13.347 None None None EM 4.4 999.0 999.0 A 1040 515 23 0 0 0 [[539, 803]] 1.0 9bcs Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCSB P16066 505 1055 1061.0 ATP:61100 ATPlike Pseudo None 999.0 999.0 None -84.33, 145.87 61.52, 18.75 -86.58, 62.78 999.0, 999.0 166.38, -163.08 out-none out 16.274 Saltbr-none 999.0 HRD-in -63.93, -40.93 80.49, -6.63 none-out-out SNCnoo out-out ActLoopNT-out 11.232 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -65.87, -23.07 APE9-dihe-na -84.75, -47.21 APE8-dihe-out -94.13, -13.59 APE8-rot-none 999.0 APE67-dihe-in -66.6, -21.85 -106.41, 28.83 APE12-dist-out 21.881 APE11-dist-out 20.406 APE10-dist-out 24.72 APE9-dist-out 14.261 None None None EM 4.4 999.0 999.0 B 1040 523 25 0 0 0 [[539, 803]] 1.0 9bcs Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
STE STRADA STRAA_HUMAN 2WTKB Q7RTN6 61 431 431.0 ANP:432 ATPlike Pseudo DFGin 5.116 13.443 BLAminus -117.01, -150.73 71.3, 24.64 -54.34, -28.38 297.58, 14.45 -57.14, -26.88 out-none out 10.016 Saltbr-none 999.0 HRD-in -75.87, -56.89 78.73, -4.32 none-in-out SNCnio in-out ActLoopNT-in 2.921 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -50.59, -53.43 APE9-dihe-na -67.53, -3.25 APE8-dihe-out -106.64, -20.66 APE8-rot-na 143.84 APE67-dihe-in -56.31, -21.98 -28.24, -53.75 APE12-dist-in 8.271 APE11-dist-out 7.456 APE10-dist-out 12.843 APE9-dist-out 9.371 None None None XRAY 2.65 0.24 0.291 B 373 311 52 0 0 0 [[69, 379]] 1.0 2wtk Homo sapiens STE_STRADA_HUMAN STE 4e-87 298.0 1 257 257 212 213 214 216 218 100 118 122 192 194 193 195 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE STRADA STRAA_HUMAN 2WTKE Q7RTN6 60 431 431.0 ANP:432 ATPlike Pseudo DFGin 5.076 13.591 BLAminus -114.47, -147.76 66.21, 35.38 -66.23, -19.97 288.54, 169.08 -50.33, -33.69 in-none in 9.934 Saltbr-none 999.0 HRD-in -67.35, -61.05 78.73, -1.12 none-in-out SNCnio in-out ActLoopNT-in 2.861 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -48.76, -50.43 APE9-dihe-na -62.69, -41.12 APE8-dihe-out -68.21, -28.45 APE8-rot-na 167.78 APE67-dihe-in -49.8, -37.77 -23.43, -57.21 APE12-dist-in 8.119 APE11-dist-out 7.643 APE10-dist-out 12.951 APE9-dist-out 9.418 None None None XRAY 2.65 0.24 0.291 E 373 308 52 0 0 0 [[69, 379]] 1.0 2wtk Homo sapiens STE_STRADA_HUMAN STE 4e-87 298.0 1 257 257 212 213 214 216 218 100 118 122 192 194 193 195 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE STRADA STRAA_HUMAN 3GNIB Q7RTN6 60 431 431.0 ATP:60001 ATPlike Pseudo DFGin 5.228 13.358 BLAminus -109.39, -155.43 74.77, 29.57 -67.06, -15.75 299.34, 10.06 -54.98, -34.79 in-none in 9.9 Saltbr-none 999.0 HRD-in -71.88, -63.47 83.33, 4.11 none-in-out SNCnio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -73.5, 108.36 APE9-dihe-na 128.9, -33.16 APE8-dihe-out -82.37, -8.26 APE8-rot-na 193.56 APE67-dihe-in -56.7, -25.37 -48.29, -50.45 APE12-dist-in 8.527 APE11-dist-out 7.098 APE10-dist-out 12.899 APE9-dist-out 9.897 None None None XRAY 2.35 0.207 0.254 B 389 290 56 0 0 0 [[69, 379]] 1.0 3gni Homo sapiens STE_STRADA_HUMAN STE 4.7e-87 297.8 1 257 257 212 213 214 216 218 100 118 122 192 194 193 195 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE STRADA STRAA_HUMAN 8VSUB Q7RTN6 60 401 431.0 ADP:2001 ATPlike Pseudo DFGin 5.328 13.743 None -141.72, 9.36 -84.56, 30.72 -65.1, -14.12 305.81, 3.72 -62.58, -31.2 out-none out 10.229 Saltbr-none 999.0 HRD-out -66.66, 151.23 -136.62, 153.73 none-in-out SNCnio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -55.51, -37.77 APE9-dihe-na -75.16, -6.37 APE8-dihe-out -108.58, -14.7 APE8-rot-na 180.94 APE67-dihe-in -58.61, -34.89 -50.23, -38.37 APE12-dist-in 8.342 APE11-dist-out 7.821 APE10-dist-out 13.057 APE9-dist-out 11.052 None None None EM 2.86 999.0 999.0 B 429 306 36 0 0 0 [[69, 379]] 1.0 8vsu Homo sapiens STE_STRADA_HUMAN STE 6.5e-87 297.3 1 257 257 212 213 214 216 218 100 118 122 192 194 193 195 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
TKL ILK ILK_HUMAN 9D5IA Q13418 182 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.261 6.842 None -85.91, 104.5 -70.94, -26.25 -67.8, 1.23 999.0, 999.0 -109.51, 3.6 out-out out 13.611 Saltbr-out 13.777 HRD-out 63.45, 28.98 -91.0, 110.88 out-out-out SNCooo out-out ActLoopNT-out 6.365 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -132.95, 115.89 APE9-dihe-na -99.41, -2.16 APE8-dihe-in -138.47, 54.8 APE8-rot-none 999.0 APE67-dihe-in -62.49, -23.03 -64.85, -19.12 APE12-dist-out 14.705 APE11-dist-in 13.99 APE10-dist-out 13.138 APE9-dist-out 13.265 R225A,C346S,C422S None None XRAY 1.5 0.23 0.267 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5i Homo sapiens TKL_ILK_HUMAN TKL 2.8e-62 216.7 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3KMWA Q13418 185 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.3 6.975 None -80.97, 99.65 -67.11, -24.75 -72.37, 0.55 999.0, 999.0 -103.25, 4.58 out-out out 13.496 Saltbr-out 14.041 HRD-out 59.64, 26.4 -91.04, 116.86 out-out-out SNCooo out-out ActLoopNT-out 6.367 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -122.08, 118.72 APE9-dihe-na -100.74, -5.98 APE8-dihe-in -137.53, 58.2 APE8-rot-none 999.0 APE67-dihe-in -63.57, -23.06 -67.47, -16.05 APE12-dist-out 14.71 APE11-dist-out 14.04 APE10-dist-out 13.057 APE9-dist-out 13.027 C346S,C422S None None XRAY 2.0 0.199 0.203 A 271 268 0 0 0 0 [[192, 448]] 1.0 3kmw Homo sapiens TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3REPA Q13418 185 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.264 6.894 None -81.35, 101.61 -70.12, -25.38 -69.18, -5.31 999.0, 999.0 -98.03, -0.84 out-out out 13.359 Saltbr-out 14.12 HRD-out 62.24, 23.62 -86.21, 112.03 out-out-out SNCooo out-out ActLoopNT-out 6.454 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -114.84, 122.73 APE9-dihe-na -97.69, -5.36 APE8-dihe-in -136.02, 58.25 APE8-rot-none 999.0 APE67-dihe-in -57.73, -27.19 -63.83, -23.69 APE12-dist-out 14.498 APE11-dist-in 13.981 APE10-dist-out 12.94 APE9-dist-out 13.101 C346S,C422S None None XRAY 1.8 0.206 0.238 A 271 268 0 0 0 0 [[192, 448]] 1.0 3rep Homo sapiens TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3KMUA Q13418 185 451 452.0 No_ligand No_ligand Pseudo DFGinter 8.115 7.023 None -89.09, 107.07 -68.14, -22.77 -71.11, -14.21 999.0, 999.0 -91.44, 11.74 out-out out 13.695 Saltbr-out 11.012 HRD-out 62.49, 27.89 -91.99, 115.71 out-out-out SNCooo out-out ActLoopNT-out 6.597 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -104.26, 122.36 APE9-dihe-na -103.82, -5.41 APE8-dihe-in -135.57, 56.37 APE8-rot-none 999.0 APE67-dihe-in -59.41, -24.29 -65.19, -22.44 APE12-dist-out 15.046 APE11-dist-out 14.132 APE10-dist-out 12.999 APE9-dist-out 12.97 C346S,C422S None MSE272,MSE301,MSE305,MSE326,MSE331,MSE337,MSE350,MSE375,MSE398,MSE402,MSE425,MSE429,MSE441,MSE449 XRAY 1.8 0.202 0.236 A 271 267 0 0 0 0 [[192, 448]] 1.0 3kmu Homo sapiens TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 6MIBA Q13418 183 452 452.0 No_ligand No_ligand Pseudo DFGinter 8.103 6.953 None -87.41, 112.59 -75.98, -22.17 -67.79, -12.67 999.0, 999.0 -94.49, 5.69 out-out out 14.011 Saltbr-out 12.861 HRD-out 64.37, 30.77 -90.77, 118.17 out-out-out SNCooo out-out ActLoopNT-out 6.381 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -106.73, 116.01 APE9-dihe-na -99.88, -3.31 APE8-dihe-in -137.02, 59.23 APE8-rot-none 999.0 APE67-dihe-in -59.55, -22.39 -68.5, -19.71 APE12-dist-out 15.073 APE11-dist-out 14.122 APE10-dist-out 13.25 APE9-dist-out 12.849 L207W None None XRAY 1.8 0.163 0.208 A 271 270 0 0 0 0 [[192, 448]] 1.0 6mib Homo sapiens TKL_ILK_HUMAN TKL 6.7e-62 215.4 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5HA Q13418 182 452 452.0 IRE:701 Type1 Pseudo DFGinter 8.164 7.455 None -85.0, 107.56 -70.5, -21.19 -67.61, -12.48 999.0, 999.0 -96.85, 13.46 out-out out 14.137 Saltbr-out 13.105 HRD-out 65.35, 60.25 -109.45, 119.86 out-out-out SNCooo out-out ActLoopNT-out 5.911 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -110.76, 118.05 APE9-dihe-na -102.65, -7.28 APE8-dihe-in -135.36, 55.79 APE8-rot-none 999.0 APE67-dihe-in -64.5, -21.08 -63.95, -18.26 APE12-dist-out 14.988 APE11-dist-out 14.039 APE10-dist-out 13.236 APE9-dist-out 12.723 C346S,R371Q,C422S None None XRAY 1.5 0.197 0.224 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5h Homo sapiens TKL_ILK_HUMAN TKL 1.2e-62 217.9 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5FA Q13418 182 452 452.0 DB8:501 Type1 Pseudo DFGinter 8.366 7.592 None -82.6, 123.95 -74.1, -11.79 -66.74, -13.57 999.0, 999.0 -72.54, 5.75 out-out out 14.123 Saltbr-out 15.4 HRD-out -123.23, 159.13 -69.32, -46.01 out-out-out SNCooo out-out ActLoopNT-out 5.554 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -109.48, 117.62 APE9-dihe-na -102.03, -10.5 APE8-dihe-in -134.11, 56.74 APE8-rot-none 999.0 APE67-dihe-in -63.21, -21.45 -62.91, -18.33 APE12-dist-out 15.638 APE11-dist-out 14.874 APE10-dist-out 14.406 APE9-dist-out 8.782 C346S,C422S None None XRAY 1.5 0.191 0.208 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5f Homo sapiens TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5GAAAA Q13418 182 452 452.0 A1A2V:501 Type1 Pseudo DFGinter 8.166 7.277 None -88.06, 117.11 -74.33, -18.91 -68.4, -19.72 999.0, 999.0 -87.44, 16.53 out-out out 13.771 Saltbr-out 14.663 HRD-out 59.25, 38.65 -103.86, 109.49 out-out-out SNCooo out-out ActLoopNT-out 6.383 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -94.88, 120.39 APE9-dihe-na -102.76, -4.36 APE8-dihe-in -137.63, 56.3 APE8-rot-none 999.0 APE67-dihe-in -62.91, -23.12 -64.06, -19.38 APE12-dist-out 14.786 APE11-dist-in 13.895 APE10-dist-out 13.122 APE9-dist-out 13.0 C346S,C422S None None XRAY 1.55 0.195 0.221 AAAA 271 271 0 0 0 0 [[192, 448]] 1.0 9d5g Homo sapiens TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5PA Q13418 182 452 452.0 AQ4:701 Type1 Pseudo DFGinter 8.061 7.428 None -85.71, 111.19 -68.8, -21.89 -73.77, -9.11 999.0, 999.0 -96.7, 8.17 out-out out 13.852 Saltbr-out 12.926 HRD-out 65.12, 30.52 -101.22, 117.74 out-out-out SNCooo out-out ActLoopNT-out 6.577 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -117.02, 119.23 APE9-dihe-na -104.23, -7.77 APE8-dihe-in -133.36, 56.94 APE8-rot-none 999.0 APE67-dihe-in -63.3, -21.52 -64.96, -18.17 APE12-dist-out 15.043 APE11-dist-in 13.976 APE10-dist-out 12.889 APE9-dist-out 12.754 C346S,C422S None None XRAY 1.5 0.188 0.21 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5p Homo sapiens TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5EA Q13418 182 452 452.0 IRE:701,IRE:702 Type1,Type1 Pseudo DFGinter 8.017 7.524 None -89.37, 112.35 -72.14, -19.5 -70.86, -12.91 999.0, 999.0 -92.65, 14.01 out-out out 14.057 Saltbr-out 13.142 HRD-out -82.68, 123.44 -98.83, 148.34 out-out-out SNCooo out-out ActLoopNT-out 6.639 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -111.62, 119.46 APE9-dihe-na -104.32, -7.67 APE8-dihe-in -135.99, 56.58 APE8-rot-none 999.0 APE67-dihe-in -63.74, -21.2 -65.26, -17.82 APE12-dist-out 14.857 APE11-dist-in 13.808 APE10-dist-out 12.922 APE9-dist-out 11.885 C346S,C422S None None XRAY 1.5 0.188 0.21 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5e Homo sapiens TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL IRAK3 IRAK3_HUMAN 6ZIWI Q9Y616 153 451 596.0 AGS:501 ATPlike Pseudo DFGin 7.058 15.43 BLAminus -137.94, 171.27 73.33, 92.98 -113.57, 22.08 299.33, 103.06 -63.05, -21.88 in-out in 8.777 Saltbr-out 6.076 HRD-in -68.03, -51.72 91.9, -24.04 out-in-none SNCoin in-none ActLoopNT-in 2.637 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.65, -29.02 999.0, 37.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.18 0.218 0.25 I 316 267 32 0 0 19 [[164, 445]] 1.0 6ziw Homo sapiens TKL_IRAK3_HUMAN TKL 2.1e-70 243.3 4 266 263 310 311 312 314 316 192 212 216 290 292 291 293 356 344 339 338 337 336 335 334 333 242 Interleukin-1 receptor-associated kinase 3
TKL IRAK3 IRAK3_HUMAN 6RUUA Q9Y616 153 450 596.0 No_ligand No_ligand Pseudo DFGin 7.326 14.884 BLAminus -133.01, -174.08 57.44, 64.43 -91.56, 23.98 296.73, 105.83 -64.82, -31.62 in-out in 8.014 Saltbr-out 3.618 HRD-in -76.83, -46.42 68.87, -4.54 out-in-none SNCoin in-none ActLoopNT-in 3.015 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 24.62 APE8-rot-none 999.0 APE67-dihe-in -68.1, -25.53 -116.47, 47.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.95 0.23 0.26 A 315 285 13 0 0 10 [[164, 445]] 1.0 6ruu Homo sapiens TKL_IRAK3_HUMAN TKL 2.1e-70 243.3 4 266 263 310 311 312 314 316 192 212 216 290 292 291 293 356 344 339 338 337 336 335 334 333 242 Interleukin-1 receptor-associated kinase 3
TKL IRAK3 IRAK3_HUMAN 6RUUB Q9Y616 152 452 596.0 No_ligand No_ligand Pseudo DFGin 7.022 14.986 BLAminus -150.92, 173.68 59.31, 65.47 -89.75, 25.43 295.48, 100.27 -67.54, -42.42 in-out in 7.949 Saltbr-out 4.374 HRD-in -61.73, -45.76 79.92, -72.1 out-in-out SNCoio in-out ActLoopNT-in 2.533 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -66.83, -49.08 APE9-dihe-na -65.03, -26.24 APE8-dihe-out -87.01, 8.46 APE8-rot-na 188.59 APE67-dihe-in -70.55, -3.31 -54.29, -46.92 APE12-dist-in 9.039 APE11-dist-out 6.734 APE10-dist-out 12.331 APE9-dist-out 10.531 None None None XRAY 2.95 0.23 0.26 B 315 286 15 0 0 8 [[164, 445]] 1.0 6ruu Homo sapiens TKL_IRAK3_HUMAN TKL 2.1e-70 243.3 4 266 263 310 311 312 314 316 192 212 216 290 292 291 293 356 344 339 338 337 336 335 334 333 242 Interleukin-1 receptor-associated kinase 3
TKL IRAK3 IRAK3_HUMAN 6RUUC Q9Y616 179 454 596.0 No_ligand No_ligand Pseudo None 999.0 999.0 None -144.24, -178.09 -113.97, -57.44 -128.5, 145.24 999.0, 999.0 -123.81, 150.85 out-none out 14.971 Saltbr-none 999.0 HRD-out -119.66, 97.59 -63.5, -32.53 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -98.5 APE8-dihe-out -108.73, 12.85 APE8-rot-none 999.0 APE67-dihe-in -79.09, -35.3 -69.09, 2.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.296 None None None XRAY 2.95 0.23 0.26 C 315 245 50 0 0 21 [[164, 445]] 1.0 6ruu Homo sapiens TKL_IRAK3_HUMAN TKL 2.1e-70 243.3 4 266 263 310 311 312 314 316 192 212 216 290 292 291 293 356 344 339 338 337 336 335 334 333 242 Interleukin-1 receptor-associated kinase 3
TKL KSR1 KSR1_HUMAN 9AXHC Q8IVT5 614 881 923.0 ANP:60901 ATPlike Pseudo DFGin 5.23 13.239 BLBplus -124.42, 164.81 64.66, 43.46 -90.48, 143.73 53.91, 91.43 61.22, 55.23 out-none out 14.31 Saltbr-none 999.0 HRD-in -67.1, -51.8 77.02, -11.89 none-out-out SNCnoo out-out ActLoopNT-out 7.657 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -64.2, -39.05 APE9-dihe-na -59.17, -48.89 APE8-dihe-out -66.09, -38.64 APE8-rot-na 184.07 APE67-dihe-in -61.76, -22.42 -60.74, -36.73 APE12-dist-out 16.89 APE11-dist-out 15.959 APE10-dist-out 20.499 APE9-dist-out 12.219 None None None XRAY 2.81 0.206 0.253 C 283 259 10 0 0 7 [[613, 879]] 1.0 9axh Homo sapiens TKL_KSR1_HUMAN TKL 2.1e-68 236.7 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 9AXHD Q8IVT5 613 881 923.0 ANP:60901 ATPlike Pseudo DFGin 5.246 13.229 BLBplus -126.56, 169.35 63.03, 47.69 -96.52, 141.09 54.28, 88.59 76.52, 29.36 out-none out 14.488 Saltbr-none 999.0 HRD-in -67.9, -47.78 73.32, -2.62 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -60.7, -40.23 APE9-dihe-na -60.83, -42.14 APE8-dihe-out -70.49, -38.33 APE8-rot-na 183.99 APE67-dihe-in -64.38, -16.08 -60.51, -36.42 APE12-dist-out 17.087 APE11-dist-out 16.228 APE10-dist-out 20.701 APE9-dist-out 12.597 None None None XRAY 2.81 0.206 0.253 D 283 249 20 0 0 13 [[613, 879]] 1.0 9axh Homo sapiens TKL_KSR1_HUMAN TKL 2.1e-68 236.7 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUWB Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.479 13.436 BLBplus -116.78, 175.7 58.02, 37.9 -91.13, 161.87 61.57, 85.28 62.4, -8.11 out-none out 13.34 Saltbr-none 999.0 HRD-in -64.36, -50.52 68.6, 3.9 none-out-out SNCnoo out-out ActLoopNT-out 7.126 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -75.12, -46.44 APE9-dihe-na -49.25, -41.63 APE8-dihe-out -65.16, -50.29 APE8-rot-na 182.96 APE67-dihe-in -55.58, -30.38 -61.8, -31.6 APE12-dist-out 17.682 APE11-dist-out 16.599 APE10-dist-out 21.026 APE9-dist-out 12.834 None None None XRAY 2.88 0.245 0.286 B 334 277 4 0 0 4 [[613, 879]] 1.0 7juw Homo sapiens TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUXA Q8IVT5 600 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.302 12.887 BLBplus -130.76, 153.55 60.79, 41.41 -77.85, 152.64 59.13, 80.46 58.16, 12.6 out-none out 13.586 Saltbr-none 999.0 HRD-out -82.48, 84.18 -62.97, 148.26 none-out-out SNCnoo out-out ActLoopNT-out 7.062 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -85.2, -42.07 APE9-dihe-na -55.8, -29.41 APE8-dihe-out -77.82, -37.67 APE8-rot-na 188.53 APE67-dihe-in -61.89, -19.45 -62.94, -36.24 APE12-dist-out 17.427 APE11-dist-out 16.235 APE10-dist-out 20.624 APE9-dist-out 14.057 None None None XRAY 3.34 0.265 0.283 A 334 278 4 0 0 4 [[613, 879]] 1.0 7jux Homo sapiens TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUYB Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.613 13.191 BLBplus -117.18, 175.18 57.71, 38.02 -91.22, 161.18 61.47, 85.63 62.09, -7.96 out-none out 13.395 Saltbr-none 999.0 HRD-in -64.77, -50.93 68.2, 3.89 none-out-out SNCnoo out-out ActLoopNT-out 7.067 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -74.87, -46.12 APE9-dihe-na -49.26, -41.38 APE8-dihe-out -64.88, -49.41 APE8-rot-na 183.95 APE67-dihe-in -56.03, -30.73 -61.35, -31.75 APE12-dist-out 17.556 APE11-dist-out 16.525 APE10-dist-out 20.947 APE9-dist-out 12.77 None None None XRAY 3.096 0.248 0.257 B 334 276 5 0 0 5 [[613, 879]] 1.0 7juy Homo sapiens TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUZA Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.251 13.144 BLBplus -120.58, 157.85 65.97, 36.71 -81.68, 149.84 60.82, 87.44 61.36, 0.32 out-none out 13.842 Saltbr-none 999.0 HRD-in -63.05, -49.06 69.65, 1.96 none-out-out SNCnoo out-out ActLoopNT-out 6.963 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -71.77, -43.35 APE9-dihe-na -54.66, -39.8 APE8-dihe-out -69.49, -39.39 APE8-rot-na 184.11 APE67-dihe-in -64.95, -32.88 -59.75, -32.59 APE12-dist-out 17.573 APE11-dist-out 16.418 APE10-dist-out 20.831 APE9-dist-out 12.592 None None None XRAY 3.21 0.255 0.272 A 334 273 8 0 0 8 [[613, 879]] 1.0 7juz Homo sapiens TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JV0A Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.544 13.231 BLBplus -113.37, 179.62 53.84, 36.37 -87.67, 157.34 63.1, 86.33 73.66, -16.65 out-none out 13.335 Saltbr-none 999.0 HRD-in -63.7, -53.29 73.57, 2.92 none-out-out SNCnoo out-out ActLoopNT-out 7.005 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -74.36, -44.01 APE9-dihe-na -53.64, -41.33 APE8-dihe-out -66.6, -51.73 APE8-rot-na 184.61 APE67-dihe-in -59.37, -29.99 -47.75, -40.44 APE12-dist-out 17.632 APE11-dist-out 16.659 APE10-dist-out 21.083 APE9-dist-out 12.781 None None None XRAY 3.63 0.247 0.26 A 334 276 5 0 0 5 [[613, 879]] 1.0 7jv0 Homo sapiens TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JV1D Q8IVT5 600 881 923.0 ANP:901 ATPlike Pseudo DFGin 4.998 13.028 BLBplus -130.92, 154.93 60.0, 40.35 -76.18, 155.67 58.85, 79.94 54.95, 12.06 out-none out 13.786 Saltbr-none 999.0 HRD-out -81.07, 84.18 -62.62, 147.5 none-out-out SNCnoo out-out ActLoopNT-out 6.808 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -83.95, -45.7 APE9-dihe-na -55.75, -29.37 APE8-dihe-out -76.69, -37.65 APE8-rot-na 188.09 APE67-dihe-in -60.65, -19.03 -62.72, -36.82 APE12-dist-out 17.487 APE11-dist-out 16.348 APE10-dist-out 20.808 APE9-dist-out 14.145 None None None XRAY 3.62 0.278 0.303 D 334 275 7 0 0 7 [[613, 879]] 1.0 7jv1 Homo sapiens TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR2 KSR2_HUMAN 2Y4IB Q6VAB6 653 931 950.0 ATP:1932 ATPlike Pseudo DFGin 6.039 13.357 BLBplus -163.04, 167.92 56.95, 32.67 -75.07, 155.41 46.1, 92.34 53.05, 51.5 out-none out 15.58 Saltbr-none 999.0 HRD-in -80.25, -38.53 67.56, -67.09 none-out-out SNCnoo out-out ActLoopNT-out 10.43 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -56.45, -137.53 APE9-dihe-na -67.8, 7.84 APE8-dihe-out -54.46, -37.41 APE8-rot-na 170.99 APE67-dihe-in -92.05, 13.42 -60.84, -28.22 APE12-dist-out 17.417 APE11-dist-out 14.576 APE10-dist-out 17.158 APE9-dist-out 12.262 None None None XRAY 3.46 0.233 0.293 B 319 265 14 0 0 10 [[665, 930]] 1.0 2y4i Homo sapiens TKL_KSR2_HUMAN TKL 1.1e-70 244.1 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUQB Q6VAB6 652 932 950.0 ADP:1001 ATPlike Pseudo DFGin 5.723 13.43 BLBplus -139.35, 152.22 61.66, 33.54 -71.04, 141.2 52.07, 82.92 82.4, -21.94 out-none out 15.389 Saltbr-none 999.0 HRD-in -71.47, -51.16 73.41, 1.02 none-out-out SNCnoo out-out ActLoopNT-out 7.459 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -57.45, -45.23 APE9-dihe-na -90.48, -7.37 APE8-dihe-out -66.85, -54.6 APE8-rot-na 183.3 APE67-dihe-in -71.76, -8.04 -52.06, -44.72 APE12-dist-out 18.487 APE11-dist-out 15.103 APE10-dist-out 19.519 APE9-dist-out 11.963 None None None XRAY 3.22 0.256 0.288 B 342 277 4 0 0 3 [[665, 930]] 1.0 7juq Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JURB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.534 13.444 BLBplus -136.74, 172.29 64.43, 21.01 -64.29, 145.08 51.43, 88.21 72.32, -17.93 out-none out 13.058 Saltbr-none 999.0 HRD-in -74.46, -55.37 71.55, 3.38 none-out-out SNCnoo out-out ActLoopNT-out 7.607 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -61.97, 131.45 APE9-dihe-na 84.3, -3.37 APE8-dihe-out -70.0, -57.71 APE8-rot-na 184.79 APE67-dihe-in -71.0, 1.52 -53.02, -42.72 APE12-dist-out 18.483 APE11-dist-out 15.136 APE10-dist-out 19.742 APE9-dist-out 12.323 None None None XRAY 2.82 0.237 0.277 B 342 277 4 0 0 3 [[665, 930]] 1.0 7jur Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUSB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.883 13.383 BLBplus -127.91, 171.08 62.77, 22.74 -63.47, 150.27 47.2, 86.11 68.89, -21.25 out-none out 13.513 Saltbr-none 999.0 HRD-in -73.66, -56.88 73.44, -2.22 none-out-out SNCnoo out-out ActLoopNT-out 7.508 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -57.38, 137.79 APE9-dihe-na 90.37, -24.33 APE8-dihe-out -66.74, -57.02 APE8-rot-na 187.61 APE67-dihe-in -75.11, -1.38 -58.95, -34.29 APE12-dist-out 18.421 APE11-dist-out 15.077 APE10-dist-out 19.629 APE9-dist-out 12.036 None None None XRAY 2.99 0.249 0.265 B 342 276 5 0 0 4 [[665, 930]] 1.0 7jus Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUTB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.556 12.961 BLBplus -137.17, 153.82 70.92, 32.74 -74.86, 135.77 48.5, 88.18 74.13, -4.82 out-none out 14.209 Saltbr-none 999.0 HRD-in -85.35, -39.03 46.26, 13.05 none-out-out SNCnoo out-out ActLoopNT-out 7.196 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -53.57, -55.36 APE9-dihe-na -91.09, 3.18 APE8-dihe-out -71.8, -46.41 APE8-rot-na 181.21 APE67-dihe-in -68.18, -7.53 -62.86, -41.09 APE12-dist-out 18.127 APE11-dist-out 15.431 APE10-dist-out 19.558 APE9-dist-out 11.925 None None None XRAY 3.09 0.259 0.3 B 342 277 4 0 0 3 [[665, 930]] 1.0 7jut Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUUB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.773 13.221 BLBplus -133.64, 151.36 70.73, 33.64 -75.25, 133.98 46.29, 83.15 80.08, -8.46 out-none out 14.433 Saltbr-none 999.0 HRD-in -73.56, -47.69 67.59, 2.06 none-out-out SNCnoo out-out ActLoopNT-out 7.385 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -58.47, -51.54 APE9-dihe-na -86.76, 0.87 APE8-dihe-out -74.62, -44.43 APE8-rot-na 183.38 APE67-dihe-in -73.96, -6.37 -64.52, -36.97 APE12-dist-out 18.347 APE11-dist-out 15.59 APE10-dist-out 19.794 APE9-dist-out 12.093 None None None XRAY 3.19 0.242 0.258 B 342 277 4 0 0 3 [[665, 930]] 1.0 7juu Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUVB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.981 13.017 BLBplus -127.69, 170.94 63.29, 22.28 -64.16, 148.8 47.81, 86.58 68.48, -22.21 out-none out 13.605 Saltbr-none 999.0 HRD-in -73.05, -56.86 73.65, -2.34 none-out-out SNCnoo out-out ActLoopNT-out 7.503 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -57.84, 138.27 APE9-dihe-na 90.88, -24.23 APE8-dihe-out -67.14, -55.82 APE8-rot-na 188.73 APE67-dihe-in -75.46, -2.03 -58.92, -34.4 APE12-dist-out 18.296 APE11-dist-out 15.175 APE10-dist-out 19.835 APE9-dist-out 12.199 None None None XRAY 3.36 0.242 0.255 B 342 277 4 0 0 3 [[665, 930]] 1.0 7juv Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7UMBB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.511 13.333 BLBplus -122.69, -178.17 55.62, 31.28 -75.96, 141.02 47.41, 88.89 74.01, -10.38 out-none out 13.077 Saltbr-none 999.0 HRD-in -83.2, -50.32 69.21, 5.46 none-out-out SNCnoo out-out ActLoopNT-out 7.53 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -52.68, 124.31 APE9-dihe-na 106.73, -20.32 APE8-dihe-out -71.55, -49.08 APE8-rot-na 185.38 APE67-dihe-in -79.33, 2.43 -65.58, -32.18 APE12-dist-out 18.119 APE11-dist-out 15.398 APE10-dist-out 19.723 APE9-dist-out 12.009 None None None XRAY 3.231 0.231 0.268 B 342 277 4 0 0 3 [[665, 930]] 1.0 7umb Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 5KKRB Q6VAB6 650 932 950.0 6U7:1001 Type1.5_Back Pseudo DFGin 6.321 13.655 BLBplus -128.93, 179.91 52.58, 42.95 -101.79, 139.35 57.86, 93.35 75.81, -29.93 out-none out 15.513 Saltbr-none 999.0 HRD-in -70.05, -32.28 58.42, -72.83 none-out-out SNCnoo out-out ActLoopNT-out 9.734 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -86.49, -61.06 APE9-dihe-na -69.5, -38.89 APE8-dihe-out -67.94, -23.77 APE8-rot-na 175.88 APE67-dihe-in -97.86, 0.75 -65.39, -34.36 APE12-dist-out 17.673 APE11-dist-out 15.152 APE10-dist-out 19.8 APE9-dist-out 10.565 None None None XRAY 3.509 0.252 0.287 B 319 272 11 0 0 5 [[665, 930]] 1.0 5kkr Homo sapiens TKL_KSR2_HUMAN TKL 1.1e-70 244.1 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TYR ERBB3 ERBB3_HUMAN 3KEXA P21860 698 994 1342.0 ANP:60001 ATPlike Pseudo DFGin 5.66 12.692 BLBplus -136.97, 172.9 58.22, 40.12 -96.04, 155.03 48.2, 92.31 69.55, -19.76 out-na out 15.235 Saltbr-na 999.0 HRD-in -90.16, -54.52 74.78, -7.72 na-out-out SNCaoo out-out ActLoopNT-out 6.728 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.57 APE8-dihe-out -99.2, 24.49 APE8-rot-na 333.43 APE67-dihe-in -74.24, 11.38 -68.56, -18.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.774 None None None XRAY 2.797 0.243 0.283 A 325 292 5 0 0 5 [[709, 967]] 1.0 3kex Homo sapiens TYR_ERBB3_HUMAN TYR 6e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3KEXB P21860 698 988 1342.0 ANP:60002 ATPlike Pseudo DFGin 5.652 12.673 BLBplus -137.46, 172.26 58.51, 39.18 -94.14, 155.27 47.87, 93.32 68.94, -19.33 out-na out 15.232 Saltbr-na 999.0 HRD-in -90.89, -54.23 74.6, -7.22 na-out-out SNCaoo out-out ActLoopNT-out 6.727 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.38 APE8-dihe-out -51.8, -10.63 APE8-rot-na 330.98 APE67-dihe-in -73.43, 11.3 -67.12, -27.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.215 None None None XRAY 2.797 0.243 0.283 B 325 283 7 0 0 7 [[709, 967]] 1.0 3kex Homo sapiens TYR_ERBB3_HUMAN TYR 6e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIWA P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.665 12.919 BLBplus -124.68, 170.7 61.91, 32.93 -86.72, 138.2 53.99, 90.7 80.0, -6.46 out-na out 15.12 Saltbr-na 999.0 HRD-in -76.0, -53.69 67.87, 2.11 na-out-none SNCaon out-none ActLoopNT-out 6.632 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -2.58 APE8-rot-na 28.66 APE67-dihe-in -88.2, -5.19 -70.28, -23.24 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.233 0.287 A 326 269 12 0 0 12 [[709, 967]] 1.0 4riw Homo sapiens TYR_ERBB3_HUMAN TYR 6.1e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIWC P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.618 13.032 BLBplus -125.06, 170.64 62.1, 33.09 -86.97, 138.33 54.47, 90.5 80.01, -6.38 out-na out 15.49 Saltbr-na 999.0 HRD-in -75.9, -53.21 67.39, 0.69 na-out-out SNCaoo out-out ActLoopNT-out 6.393 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -113.39, 20.05 APE9-dihe-in -68.39, 127.6 APE8-dihe-out -63.99, -4.42 APE8-rot-na 333.17 APE67-dihe-in -86.76, -6.22 -71.15, -22.24 APE12-dist-na 21.544 APE11-dist-na 20.419 APE10-dist-na 15.408 APE9-dist-out 10.083 None None None XRAY 3.1 0.233 0.287 C 326 275 6 0 0 0 [[709, 967]] 1.0 4riw Homo sapiens TYR_ERBB3_HUMAN TYR 6.1e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3LMGA P21860 699 978 1342.0 ANP:60301 ATPlike Pseudo DFGin 5.728 12.964 BLBplus -117.83, 170.87 63.58, 24.7 -69.26, 132.03 43.93, 98.75 70.87, 7.13 out-na out 15.578 Saltbr-na 999.0 HRD-in -64.67, -52.37 74.61, 1.05 na-out-out SNCaoo out-out ActLoopNT-out 6.623 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 104.53 APE8-dihe-out -45.34, -17.97 APE8-rot-na 330.0 APE67-dihe-in -71.66, -7.63 -57.32, -31.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.464 None None None XRAY 2.8 0.255 0.285 A 344 268 12 0 0 9 [[709, 967]] 1.0 3lmg Homo sapiens TYR_ERBB3_HUMAN TYR 7.3e-80 274.0 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3LMGB P21860 699 978 1342.0 ANP:60301 ATPlike Pseudo DFGin 5.789 12.844 BLBplus -113.43, 165.54 66.13, 22.95 -73.3, 147.22 48.63, 94.29 81.01, -18.45 out-na out 15.381 Saltbr-na 999.0 HRD-in -77.74, -52.9 74.69, -13.1 na-out-none SNCaon out-none ActLoopNT-out 6.805 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -22.84 APE8-rot-na 330.0 APE67-dihe-in -67.55, -12.53 -55.83, -37.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.255 0.285 B 344 268 12 0 0 9 [[709, 967]] 1.0 3lmg Homo sapiens TYR_ERBB3_HUMAN TYR 7.3e-80 274.0 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIYA P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.753 12.868 BLBplus -123.9, 168.71 62.98, 31.45 -82.39, 142.59 52.35, 86.17 78.8, -6.78 out-na out 15.044 Saltbr-na 999.0 HRD-in -75.26, -54.75 69.16, 2.85 na-out-none SNCaon out-none ActLoopNT-out 6.45 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -9.22 APE8-rot-na 31.12 APE67-dihe-in -85.56, -1.17 -67.69, -25.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 E928G None None XRAY 2.981 0.221 0.267 A 326 269 12 0 0 12 [[709, 967]] 1.0 4riy Homo sapiens TYR_ERBB3_HUMAN TYR 1.3e-79 273.1 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIYC P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.577 13.185 BLBplus -124.39, 168.66 63.11, 31.61 -82.48, 141.95 52.91, 86.81 78.36, -7.08 out-na out 15.605 Saltbr-na 999.0 HRD-in -74.67, -54.96 68.56, 2.02 na-out-out SNCaoo out-out ActLoopNT-out 6.525 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -99.97, 8.97 APE9-dihe-in -62.65, 132.93 APE8-dihe-out -66.25, -9.79 APE8-rot-na 341.07 APE67-dihe-in -85.25, -1.58 -67.21, -25.34 APE12-dist-na 22.285 APE11-dist-na 20.535 APE10-dist-na 15.613 APE9-dist-out 10.163 E928G None None XRAY 2.981 0.221 0.267 C 326 275 6 0 0 0 [[709, 967]] 1.0 4riy Homo sapiens TYR_ERBB3_HUMAN TYR 1.3e-79 273.1 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIXA P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.534 12.788 BLBplus -125.2, 170.11 60.89, 28.84 -82.14, 140.77 56.51, 90.87 77.72, -6.25 out-na out 15.04 Saltbr-na 999.0 HRD-in -77.1, -53.12 66.52, 0.72 na-out-none SNCaon out-none ActLoopNT-out 6.513 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -5.5 APE8-rot-na 30.9 APE67-dihe-in -82.84, -10.3 -67.07, -25.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q809R None None XRAY 3.1 0.21 0.258 A 326 269 12 0 0 12 [[709, 967]] 1.0 4rix Homo sapiens TYR_ERBB3_HUMAN TYR 9.7e-80 273.5 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIXC P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.557 13.116 BLBplus -126.64, 170.72 61.2, 28.92 -82.69, 140.73 56.76, 91.32 77.44, -6.2 out-na out 15.473 Saltbr-na 999.0 HRD-in -76.48, -52.61 66.58, -0.13 na-out-out SNCaoo out-out ActLoopNT-out 6.372 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -112.15, 5.58 APE9-dihe-in -58.87, 135.06 APE8-dihe-out -71.85, -6.39 APE8-rot-na 348.17 APE67-dihe-in -82.4, -10.58 -67.81, -25.66 APE12-dist-na 21.658 APE11-dist-na 20.612 APE10-dist-na 15.605 APE9-dist-out 9.969 Q809R None None XRAY 3.1 0.21 0.258 C 326 275 6 0 0 0 [[709, 967]] 1.0 4rix Homo sapiens TYR_ERBB3_HUMAN TYR 9.7e-80 273.5 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 6OP9A P21860 699 979 1342.0 DB8:61101 Type1 Pseudo DFGin 5.807 13.202 BLBplus -112.2, 168.23 74.7, 17.55 -72.83, 138.03 47.72, 93.08 81.75, -11.37 out-na out 15.256 Saltbr-na 999.0 HRD-in -65.5, -60.79 78.74, 0.36 na-out-out SNCaoo out-out ActLoopNT-out 6.69 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -72.9, -25.26 APE9-dihe-in -116.6, 159.4 APE8-dihe-in -83.21, 75.09 APE8-rot-na 31.73 APE67-dihe-in -70.29, -6.2 -48.51, -45.47 APE12-dist-na 999.0 APE11-dist-na 18.44 APE10-dist-na 14.221 APE9-dist-in 7.834 None None None XRAY 2.501 0.173 0.23 A 328 276 5 0 0 5 [[709, 967]] 1.0 6op9 Homo sapiens TYR_ERBB3_HUMAN TYR 6.2e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR JAK1-1 JAK1_HUMAN 4L01A P23458 565 850 1154.0 No_ligand No_ligand Pseudo DFGin 6.792 12.079 None -73.75, -179.09 -73.9, 162.14 -73.89, -15.61 344.71, 28.42 67.96, -153.13 in-na in 9.543 Saltbr-na 999.0 HRD-in -87.9, -71.89 94.16, -0.24 na-out-out SNCaoo out-out ActLoopNT-out 7.954 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.86, -39.57 APE9-dihe-out -58.05, -29.58 APE8-dihe-out -81.67, -7.08 APE8-rot-na 199.85 APE67-dihe-out -101.51, 19.28 -61.73, 134.72 APE12-dist-na 9.341 APE11-dist-na 11.755 APE10-dist-na 15.957 APE9-dist-out 11.126 V658F None None XRAY 1.9 0.204 0.233 A 304 274 12 0 0 0 [[583, 847], [875, 1151]] 2.0 4l01 Homo sapiens TYR_JAK1-1_HUMAN TYR 9.9e-61 211.3 2 260 259 738 739 740 742 744 622 638 642 711 713 712 714 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
TYR JAK1-1 JAK1_HUMAN 4L01B P23458 565 849 1154.0 No_ligand No_ligand Pseudo DFGin 6.823 11.872 None -76.74, -176.42 -72.49, 166.45 -77.53, -11.38 359.0, 15.1 69.24, -153.25 in-na in 8.893 Saltbr-na 999.0 HRD-in -86.59, -73.54 93.9, -0.47 na-out-out SNCaoo out-out ActLoopNT-out 8.016 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -57.69, -39.64 APE9-dihe-out -57.55, -28.87 APE8-dihe-out -85.94, -3.15 APE8-rot-na 200.27 APE67-dihe-out -99.61, 21.88 -63.69, 136.29 APE12-dist-na 9.299 APE11-dist-na 11.695 APE10-dist-na 15.846 APE9-dist-out 11.03 V658F None None XRAY 1.9 0.204 0.233 B 304 274 11 0 0 0 [[583, 847], [875, 1151]] 2.0 4l01 Homo sapiens TYR_JAK1-1_HUMAN TYR 9.9e-61 211.3 2 260 259 738 739 740 742 744 622 638 642 711 713 712 714 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
TYR JAK1-1 JAK1_HUMAN 4L00A P23458 564 850 1154.0 No_ligand No_ligand Pseudo DFGin 6.912 11.988 None -76.07, -177.45 -75.3, 165.45 -78.74, -7.85 349.06, 24.36 63.89, -153.3 in-na in 9.561 Saltbr-na 999.0 HRD-in -93.36, -71.42 93.51, 0.78 na-out-out SNCaoo out-out ActLoopNT-out 7.961 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.21, -40.39 APE9-dihe-out -55.79, -30.01 APE8-dihe-out -85.56, 0.43 APE8-rot-na 187.12 APE67-dihe-out -101.03, 20.07 -69.52, 138.76 APE12-dist-na 9.496 APE11-dist-na 11.88 APE10-dist-na 16.127 APE9-dist-out 11.163 None None None XRAY 1.8 0.171 0.203 A 304 277 10 0 0 0 [[583, 847], [875, 1151]] 2.0 4l00 Homo sapiens TYR_JAK1-1_HUMAN TYR 5.2e-61 212.2 2 260 259 738 739 740 742 744 622 638 642 711 713 712 714 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
TYR JAK1-1 JAK1_HUMAN 4L00B P23458 565 850 1154.0 No_ligand No_ligand Pseudo DFGin 6.872 11.974 None -78.39, -173.09 -77.68, 164.49 -74.46, -8.56 347.77, 22.41 63.58, -153.63 in-na in 8.973 Saltbr-na 999.0 HRD-in -90.15, -72.75 94.75, 3.66 na-out-out SNCaoo out-out ActLoopNT-out 7.929 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.66, -39.95 APE9-dihe-out -56.84, -31.4 APE8-dihe-out -81.07, -3.08 APE8-rot-na 200.04 APE67-dihe-out -104.62, 20.8 -63.46, 134.32 APE12-dist-na 9.37 APE11-dist-na 11.85 APE10-dist-na 15.911 APE9-dist-out 11.081 None None None XRAY 1.8 0.171 0.203 B 304 278 8 0 0 0 [[583, 847], [875, 1151]] 2.0 4l00 Homo sapiens TYR_JAK1-1_HUMAN TYR 5.2e-61 212.2 2 260 259 738 739 740 742 744 622 638 642 711 713 712 714 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
TYR JAK2-1 JAK2_HUMAN 5I4NA O60674 537 809 1132.0 ATP:61000 ATPlike Pseudo DFGin 5.668 13.386 None -68.19, 172.29 -64.41, 158.19 -73.31, -26.63 342.84, 34.8 77.82, -169.16 out-na out 11.405 Saltbr-na 999.0 HRD-in -78.6, -60.98 86.96, 3.87 na-out-out SNCaoo out-out ActLoopNT-out 8.681 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.12, -41.49 APE9-dihe-out -58.18, -29.35 APE8-dihe-out -88.11, 6.74 APE8-rot-na 290.83 APE67-dihe-out -103.83, 26.01 -65.06, 135.53 APE12-dist-na 10.037 APE11-dist-na 11.7 APE10-dist-na 16.278 APE9-dist-out 12.372 E596A,V617F,W659A,W777A,F794H None None XRAY 1.54 0.174 0.193 A 290 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5i4n Homo sapiens TYR_JAK2-1_HUMAN TYR 7.1e-64 221.5 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVRA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 5.766 13.376 None -77.86, -178.54 -72.61, 163.95 -75.06, -27.39 334.11, 39.64 77.27, -166.65 out-na out 11.782 Saltbr-na 999.0 HRD-in -74.66, -57.27 90.8, -3.55 na-out-out SNCaoo out-out ActLoopNT-out 8.537 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.48, -33.68 APE9-dihe-out -63.8, -34.8 APE8-dihe-out -85.1, 11.44 APE8-rot-na 293.02 APE67-dihe-out -101.64, 24.24 -66.8, 135.55 APE12-dist-na 9.675 APE11-dist-na 11.473 APE10-dist-na 16.037 APE9-dist-out 12.028 V617F,W777A,F794H None None XRAY 2.0 0.183 0.229 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4fvr Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVQA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 6.411 13.531 None -82.38, -178.3 -71.29, 157.18 -64.23, -31.16 342.38, 32.32 77.45, -167.94 out-na out 10.357 Saltbr-na 999.0 HRD-in -81.79, -59.57 93.66, -10.87 na-out-out SNCaoo out-out ActLoopNT-out 9.094 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.14, -35.28 APE9-dihe-out -67.39, -22.98 APE8-dihe-out -92.26, 6.93 APE8-rot-na 290.03 APE67-dihe-out -106.47, 27.81 -64.4, 133.6 APE12-dist-na 9.912 APE11-dist-na 11.487 APE10-dist-na 16.075 APE9-dist-out 12.378 W659A,W777A,F794H None None XRAY 1.75 0.176 0.199 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4fvq Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08A O60674 537 810 1132.0 ATP:901 ATPlike Pseudo DFGin 6.598 13.736 None -72.21, 176.69 -66.6, 164.57 -72.8, -15.2 349.18, 27.02 73.34, -163.25 in-na in 9.4 Saltbr-na 999.0 HRD-in -80.72, -74.63 111.24, -16.83 na-out-out SNCaoo out-out ActLoopNT-out 9.474 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -55.86, -37.52 APE9-dihe-out -72.05, -28.92 APE8-dihe-out -74.69, -10.21 APE8-rot-na 283.12 APE67-dihe-out -93.42, 18.23 -54.81, 139.34 APE12-dist-na 9.92 APE11-dist-na 11.859 APE10-dist-na 16.352 APE9-dist-out 12.53 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 A 289 270 4 0 0 0 [[545, 807], [849, 1125]] 2.0 8c08 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08B O60674 536 810 1132.0 ATP:901 ATPlike Pseudo DFGin 5.646 13.539 None -63.04, -178.12 -72.48, 164.14 -59.19, -39.37 337.51, 34.58 89.58, -173.09 out-na out 12.178 Saltbr-na 999.0 HRD-in -76.08, -63.96 89.49, 0.26 na-out-out SNCaoo out-out ActLoopNT-out 8.73 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.09, -36.29 APE9-dihe-out -67.21, -14.45 APE8-dihe-out -97.09, 0.9 APE8-rot-na 279.42 APE67-dihe-out -95.31, 21.21 -63.75, 135.54 APE12-dist-na 10.848 APE11-dist-na 11.837 APE10-dist-na 16.6 APE9-dist-out 12.658 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 B 289 269 6 0 0 0 [[545, 807], [849, 1125]] 2.0 8c08 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA4B O60674 536 809 1132.0 No_ligand No_ligand Pseudo DFGin 7.016 13.629 None -84.33, -175.92 -78.92, 160.47 -67.97, -29.51 344.52, 29.43 84.02, -159.01 out-na out 10.548 Saltbr-na 999.0 HRD-in -80.56, -60.88 93.85, -0.35 na-out-out SNCaoo out-out ActLoopNT-out 9.253 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.77, -41.18 APE9-dihe-out -60.58, -30.76 APE8-dihe-out -85.29, 2.29 APE8-rot-na 288.75 APE67-dihe-out -100.46, 22.84 -59.03, 138.57 APE12-dist-na 9.67 APE11-dist-na 11.398 APE10-dist-na 15.935 APE9-dist-out 12.667 W659A,W777A,F794H None None XRAY 2.1 0.219 0.274 B 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8ba4 Homo sapiens TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVPA O60674 536 809 1132.0 No_ligand No_ligand Pseudo DFGin 7.893 13.09 None -91.01, 179.45 -75.79, 153.56 -78.3, -11.29 26.93, 143.21 73.75, -158.65 out-na out 13.166 Saltbr-na 999.0 HRD-in -83.21, -62.84 93.75, -4.6 na-out-out SNCaoo out-out ActLoopNT-out 9.629 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.0, -41.33 APE9-dihe-out -58.79, -30.31 APE8-dihe-out -86.85, 3.46 APE8-rot-na 297.22 APE67-dihe-out -102.61, 25.98 -63.62, 134.65 APE12-dist-na 9.883 APE11-dist-na 11.675 APE10-dist-na 16.144 APE9-dist-out 12.543 W659A,W777A,F794H None None XRAY 2.01 0.181 0.212 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4fvp Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C09A O60674 538 809 1132.0 No_ligand No_ligand Pseudo DFGin 7.053 13.253 None -86.22, -176.26 -73.29, 161.33 -72.41, -30.09 344.35, 29.81 80.16, -162.74 out-na out 11.184 Saltbr-na 999.0 HRD-in -80.44, -66.09 97.2, -4.64 na-out-out SNCaoo out-out ActLoopNT-out 9.079 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.51, -34.73 APE9-dihe-out -64.77, -31.42 APE8-dihe-out -84.71, 1.64 APE8-rot-na 292.35 APE67-dihe-out -99.58, 28.31 -60.08, 137.86 APE12-dist-na 9.864 APE11-dist-na 11.557 APE10-dist-na 16.122 APE9-dist-out 12.483 I559F,W659A,W777A,F794H None None XRAY 1.9 0.223 0.257 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8c09 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.3e-63 220.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6G3CA O60674 537 808 1132.0 EKT:901 Type1 Pseudo DFGin 7.929 13.297 None -92.88, -174.23 -74.55, 160.0 -77.81, -9.76 27.51, 143.79 70.13, -167.0 in-na in 9.462 Saltbr-na 999.0 HRD-in -89.47, -61.45 91.27, -4.79 na-out-out SNCaoo out-out ActLoopNT-out 9.753 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.76, -39.79 APE9-dihe-out -61.91, -29.13 APE8-dihe-out -80.12, 0.2 APE8-rot-na 289.19 APE67-dihe-out -101.75, 22.48 -69.62, 136.72 APE12-dist-na 9.767 APE11-dist-na 11.566 APE10-dist-na 16.154 APE9-dist-out 12.702 W659A,W777A,F794H None None XRAY 1.6 0.196 0.22 A 272 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6g3c Homo sapiens TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6G3CB O60674 537 808 1132.0 EKT:901 Type1 Pseudo DFGin 7.99 13.415 None -91.77, -175.11 -73.45, 159.45 -76.52, -11.86 28.49, 143.52 73.41, -164.04 in-na in 9.643 Saltbr-na 999.0 HRD-in -89.94, -61.82 90.1, -3.95 na-out-out SNCaoo out-out ActLoopNT-out 9.693 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.88, -39.41 APE9-dihe-out -62.88, -28.18 APE8-dihe-out -81.21, 1.24 APE8-rot-na 288.18 APE67-dihe-out -102.69, 23.29 -70.43, 136.03 APE12-dist-na 9.769 APE11-dist-na 11.58 APE10-dist-na 16.138 APE9-dist-out 12.69 W659A,W777A,F794H None None XRAY 1.6 0.196 0.22 B 272 268 4 0 0 0 [[545, 807], [849, 1125]] 2.0 6g3c Homo sapiens TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6D2IA O60674 536 808 1132.0 35R:901 Type1 Pseudo DFGin 6.552 13.651 None -85.6, -168.64 -71.02, 159.25 -67.8, -19.61 341.93, 32.5 72.61, -145.53 in-na in 9.639 Saltbr-na 999.0 HRD-in -88.15, -70.56 100.36, -8.76 na-out-out SNCaoo out-out ActLoopNT-out 9.7 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.19, -30.63 APE9-dihe-out -73.76, -13.56 APE8-dihe-out -89.52, 2.58 APE8-rot-na 300.29 APE67-dihe-out -99.98, 28.53 -66.76, 135.82 APE12-dist-na 10.52 APE11-dist-na 11.514 APE10-dist-na 16.315 APE9-dist-out 13.019 W659A,W777A,F794H None None XRAY 3.192 0.272 0.29 A 273 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6d2i Homo sapiens TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6D2IB O60674 537 808 1132.0 35R:901 Type1 Pseudo DFGin 6.745 13.508 None -83.97, -172.62 -69.78, 158.02 -65.46, -20.62 341.26, 32.34 71.79, -145.54 in-na in 9.436 Saltbr-na 999.0 HRD-in -84.58, -69.97 97.0, -6.55 na-out-out SNCaoo out-out ActLoopNT-out 9.449 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.97, -30.79 APE9-dihe-out -72.59, -17.09 APE8-dihe-out -89.77, 2.61 APE8-rot-na 301.92 APE67-dihe-out -99.31, 27.86 -67.19, 135.78 APE12-dist-na 10.586 APE11-dist-na 11.89 APE10-dist-na 16.65 APE9-dist-out 12.896 W659A,W777A,F794H None None XRAY 3.192 0.272 0.29 B 273 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6d2i Homo sapiens TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B8NA O60674 536 809 1132.0 AQG:904 Type1 Pseudo DFGin 6.992 13.559 None -86.6, 176.83 -72.07, 163.0 -83.55, -11.71 8.83, 7.64 73.11, -166.45 out-na out 10.223 Saltbr-na 999.0 HRD-in -77.47, -60.54 92.78, -1.1 na-out-out SNCaoo out-out ActLoopNT-out 9.255 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.27, -38.06 APE9-dihe-out -61.66, -30.26 APE8-dihe-out -80.2, 3.05 APE8-rot-na 289.81 APE67-dihe-out -99.17, 33.25 -63.6, 138.44 APE12-dist-na 9.554 APE11-dist-na 11.448 APE10-dist-na 15.97 APE9-dist-out 12.453 W659A,W777A,F794H None None XRAY 2.0 0.211 0.255 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8b8n Homo sapiens TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B8UA O60674 536 809 1132.0 T7I:902 Type1 Pseudo DFGin 7.821 13.298 None -86.5, 168.2 -72.83, 159.81 -77.39, -5.69 29.32, 142.66 68.85, -165.5 in-na in 9.637 Saltbr-na 999.0 HRD-in -85.53, -63.36 91.05, -0.77 na-out-out SNCaoo out-out ActLoopNT-out 9.586 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.74, -40.18 APE9-dihe-out -60.78, -27.05 APE8-dihe-out -85.5, 2.2 APE8-rot-na 288.85 APE67-dihe-out -105.88, 26.49 -64.53, 136.9 APE12-dist-na 9.839 APE11-dist-na 11.543 APE10-dist-na 16.135 APE9-dist-out 12.651 W659A,W777A,F794H None None XRAY 1.5 0.224 0.259 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8b8u Homo sapiens TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B8UB O60674 538 809 1132.0 T7I:903 Type1 Pseudo DFGin 7.684 13.367 None -85.95, 172.23 -73.23, 159.57 -79.19, -7.74 28.18, 144.77 71.86, -165.96 in-na in 9.871 Saltbr-na 999.0 HRD-in -85.44, -62.47 91.56, -1.37 na-out-out SNCaoo out-out ActLoopNT-out 9.405 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.42, -39.8 APE9-dihe-out -61.59, -26.48 APE8-dihe-out -85.69, -0.76 APE8-rot-na 289.8 APE67-dihe-out -104.95, 23.87 -61.36, 134.02 APE12-dist-na 9.893 APE11-dist-na 11.487 APE10-dist-na 16.106 APE9-dist-out 12.548 W659A,W777A,F794H None None XRAY 1.5 0.224 0.259 B 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8b8u Homo sapiens TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA2A O60674 536 810 1132.0 Q9X:907 Type1 Pseudo DFGin 5.707 13.272 None -74.82, 174.75 -67.11, 161.11 -77.71, -21.19 340.67, 34.41 73.6, -166.64 out-na out 11.657 Saltbr-na 999.0 HRD-in -83.09, -59.59 87.04, -0.99 na-out-out SNCaoo out-out ActLoopNT-out 8.949 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.59, -40.16 APE9-dihe-out -57.17, -31.99 APE8-dihe-out -85.57, 4.75 APE8-rot-na 288.77 APE67-dihe-out -102.79, 29.41 -64.21, 136.1 APE12-dist-na 9.735 APE11-dist-na 11.432 APE10-dist-na 16.018 APE9-dist-out 12.283 W659A,W777A,F794H None None XRAY 1.5 0.178 0.204 A 289 275 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8ba2 Homo sapiens TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA4A O60674 536 809 1132.0 Q8U:901 Type1 Pseudo DFGin 7.944 13.412 None -71.69, 172.79 -67.86, 161.07 -79.48, -19.97 29.54, 146.52 81.3, -166.68 in-na in 9.788 Saltbr-na 999.0 HRD-in -74.34, -63.4 91.62, 2.89 na-out-out SNCaoo out-out ActLoopNT-out 8.59 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.98, -39.28 APE9-dihe-out -56.91, -30.54 APE8-dihe-out -86.08, -1.03 APE8-rot-na 290.49 APE67-dihe-out -99.32, 21.83 -60.56, 137.6 APE12-dist-na 9.925 APE11-dist-na 11.647 APE10-dist-na 16.144 APE9-dist-out 12.327 W659A,W777A,F794H None None XRAY 2.1 0.219 0.274 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8ba4 Homo sapiens TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7F7WA O60674 536 810 1132.0 36H:1000 Type1 Pseudo DFGin 6.915 13.796 None -91.54, 171.73 -67.57, 155.24 -69.34, -22.33 351.29, 21.05 78.83, -168.1 out-na out 10.169 Saltbr-na 999.0 HRD-in -84.02, -62.23 90.48, 0.05 na-out-out SNCaoo out-out ActLoopNT-out 9.723 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.04, -35.76 APE9-dihe-out -66.77, -25.16 APE8-dihe-out -85.21, 3.67 APE8-rot-na 284.34 APE67-dihe-out -100.56, 25.85 -66.38, 135.35 APE12-dist-na 9.689 APE11-dist-na 11.473 APE10-dist-na 16.032 APE9-dist-out 12.653 None None None XRAY 1.83 0.208 0.238 A 275 275 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7f7w Homo sapiens TYR_JAK2-1_HUMAN TYR 5.3e-64 222.0 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7F7WB O60674 536 810 1132.0 36H:1000 Type1 Pseudo DFGin 6.903 13.687 None -84.95, 175.07 -74.42, 156.63 -70.62, -23.21 351.87, 21.25 77.0, -167.15 out-na out 10.252 Saltbr-na 999.0 HRD-in -79.03, -66.0 95.6, -1.12 na-out-out SNCaoo out-out ActLoopNT-out 9.495 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.33, -37.68 APE9-dihe-out -69.53, -21.97 APE8-dihe-out -87.12, 4.19 APE8-rot-na 285.11 APE67-dihe-out -99.09, 24.95 -67.63, 136.04 APE12-dist-na 9.704 APE11-dist-na 11.491 APE10-dist-na 16.017 APE9-dist-out 12.671 None None None XRAY 1.83 0.208 0.238 B 275 275 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7f7w Homo sapiens TYR_JAK2-1_HUMAN TYR 5.3e-64 222.0 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B99A O60674 536 809 1132.0 SKE:1003 Type1 Pseudo DFGin 5.829 13.19 None -69.78, 174.05 -70.57, 162.32 -72.88, -28.63 342.75, 30.69 79.14, -167.36 out-na out 11.614 Saltbr-na 999.0 HRD-in -83.46, -62.07 90.64, -3.52 na-out-out SNCaoo out-out ActLoopNT-out 8.844 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.87, -40.42 APE9-dihe-out -54.81, -33.54 APE8-dihe-out -85.07, 3.29 APE8-rot-na 283.44 APE67-dihe-out -103.17, 28.18 -66.12, 134.93 APE12-dist-na 9.764 APE11-dist-na 11.367 APE10-dist-na 15.959 APE9-dist-out 12.16 W777A,F794H None None XRAY 1.6 0.19 0.211 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8b99 Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B9EA O60674 536 809 1132.0 Q7F:1003 Type1 Pseudo DFGin 5.769 13.226 None -72.27, 175.04 -67.31, 162.54 -76.41, -26.42 340.6, 33.67 78.05, -163.23 out-na out 11.726 Saltbr-na 999.0 HRD-in -83.9, -60.17 88.41, -6.41 na-out-out SNCaoo out-out ActLoopNT-out 8.95 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.18, -39.02 APE9-dihe-out -59.74, -28.13 APE8-dihe-out -86.36, 6.28 APE8-rot-na 284.57 APE67-dihe-out -105.41, 26.85 -68.63, 134.78 APE12-dist-na 9.613 APE11-dist-na 11.316 APE10-dist-na 15.854 APE9-dist-out 12.106 W777A,F794H None None XRAY 1.5 0.17 0.194 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8b9e Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BABA O60674 536 809 1132.0 Q8N:908 Type1 Pseudo DFGin 5.783 13.347 None -82.44, 178.74 -69.43, 159.24 -76.71, -21.64 341.13, 33.08 75.74, -169.92 out-na out 11.796 Saltbr-na 999.0 HRD-in -85.23, -57.58 89.38, -3.23 na-out-out SNCaoo out-out ActLoopNT-out 9.079 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.14, -39.62 APE9-dihe-out -58.1, -35.37 APE8-dihe-out -80.74, 3.58 APE8-rot-na 288.39 APE67-dihe-out -100.89, 27.42 -62.52, 138.56 APE12-dist-na 9.881 APE11-dist-na 11.499 APE10-dist-na 16.122 APE9-dist-out 12.537 W777A,F794H None None XRAY 1.55 0.176 0.203 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bab Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BAKA O60674 536 809 1132.0 AD5:906 Type1 Pseudo DFGin 5.9 13.485 None -79.74, 176.09 -70.26, 155.83 -67.8, -33.14 338.52, 35.12 82.51, -172.71 out-na out 11.743 Saltbr-na 999.0 HRD-in -82.49, -60.1 89.16, -0.66 na-out-out SNCaoo out-out ActLoopNT-out 9.022 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.79, -43.24 APE9-dihe-out -56.17, -32.1 APE8-dihe-out -84.4, 4.03 APE8-rot-na 284.51 APE67-dihe-out -100.67, 27.47 -64.95, 137.17 APE12-dist-na 9.883 APE11-dist-na 11.588 APE10-dist-na 16.141 APE9-dist-out 12.616 W777A,F794H None None XRAY 1.65 0.185 0.207 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8bak Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C0AA O60674 536 809 1132.0 T7I:902 Type1 Pseudo DFGin 7.565 13.354 None -83.75, 166.81 -71.24, 158.41 -74.12, -10.51 25.45, 142.36 78.43, -168.66 in-na in 9.559 Saltbr-na 999.0 HRD-in -83.22, -65.0 92.23, 1.81 na-out-out SNCaoo out-out ActLoopNT-out 9.601 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -71.23, -34.89 APE9-dihe-out -65.21, -28.5 APE8-dihe-out -84.82, 8.34 APE8-rot-na 293.37 APE67-dihe-out -106.96, 23.1 -69.15, 131.91 APE12-dist-na 9.892 APE11-dist-na 11.624 APE10-dist-na 16.147 APE9-dist-out 12.571 W659A,R683S,W777A,F794H None None XRAY 1.7 0.196 0.237 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8c0a Homo sapiens TYR_JAK2-1_HUMAN TYR 1.5e-64 223.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C0AB O60674 536 808 1132.0 T7I:902 Type1 Pseudo DFGin 7.485 13.398 None -84.77, 172.51 -72.53, 156.76 -75.35, -8.78 26.64, 140.87 71.28, -164.53 in-na in 9.805 Saltbr-na 999.0 HRD-in -81.32, -65.94 88.05, 6.45 na-out-out SNCaoo out-out ActLoopNT-out 9.414 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.73, -37.68 APE9-dihe-out -64.41, -27.87 APE8-dihe-out -85.03, 1.77 APE8-rot-na 284.08 APE67-dihe-out -105.43, 24.1 -65.54, 134.17 APE12-dist-na 9.772 APE11-dist-na 11.459 APE10-dist-na 16.089 APE9-dist-out 12.496 W659A,R683S,W777A,F794H None None XRAY 1.7 0.196 0.237 B 289 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8c0a Homo sapiens TYR_JAK2-1_HUMAN TYR 1.5e-64 223.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WIJA O60674 536 809 1132.0 AQG:901 Type1 Pseudo DFGin 7.856 13.566 None -91.12, 177.94 -71.51, 155.95 -79.01, -8.25 29.98, 143.91 73.76, -166.11 in-na in 9.917 Saltbr-na 999.0 HRD-in -72.47, -68.91 101.27, -5.66 na-out-out SNCaoo out-out ActLoopNT-out 9.306 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -74.59, -26.98 APE9-dihe-out -64.74, -27.71 APE8-dihe-out -87.29, 3.84 APE8-rot-na 291.39 APE67-dihe-out -100.01, 30.88 -65.27, 134.93 APE12-dist-na 9.617 APE11-dist-na 11.495 APE10-dist-na 15.994 APE9-dist-out 12.51 W659A,W777A,F794H None None XRAY 2.04 0.209 0.231 A 277 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5wij Homo sapiens TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WIKB O60674 536 809 1132.0 584:901 Type1 Pseudo DFGin 8.2 13.477 None -86.83, -177.1 -74.98, 154.5 -75.92, -8.34 30.63, 142.46 77.38, -163.2 out-na out 10.015 Saltbr-na 999.0 HRD-in -75.13, -71.22 102.4, -1.09 na-out-out SNCaoo out-out ActLoopNT-out 9.412 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.94, -26.86 APE9-dihe-out -70.71, -25.41 APE8-dihe-out -85.62, 4.24 APE8-rot-na 286.3 APE67-dihe-out -97.88, 28.27 -66.61, 137.0 APE12-dist-na 9.663 APE11-dist-na 11.418 APE10-dist-na 16.055 APE9-dist-out 12.594 W659A,W777A,F794H None None XRAY 2.6 0.211 0.251 B 277 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5wik Homo sapiens TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WILA O60674 536 809 1132.0 YDJ:901 Type1 Pseudo DFGin 7.531 13.717 None -83.87, 163.34 -72.42, 163.18 -87.02, -3.44 24.44, 145.33 75.07, -167.72 out-na out 10.46 Saltbr-na 999.0 HRD-in -86.92, -55.39 94.23, -3.93 na-out-out SNCaoo out-out ActLoopNT-out 9.665 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.97, -30.77 APE9-dihe-out -75.41, -19.35 APE8-dihe-out -84.61, 10.2 APE8-rot-na 287.01 APE67-dihe-out -99.8, 25.99 -70.86, 137.89 APE12-dist-na 9.547 APE11-dist-na 11.481 APE10-dist-na 16.04 APE9-dist-out 12.692 W659A,W777A,F794H None None XRAY 2.2 0.201 0.231 A 277 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5wil Homo sapiens TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WIMA O60674 536 809 1132.0 35R:901 Type1 Pseudo DFGin 7.752 13.585 None -93.28, 176.5 -38.24, 151.14 -78.63, -21.68 29.2, 149.11 81.15, -169.97 out-na out 10.568 Saltbr-na 999.0 HRD-in -83.09, -66.39 96.8, 0.86 na-out-out SNCaoo out-out ActLoopNT-out 9.85 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -105.18, -10.47 APE9-dihe-out -83.98, -20.52 APE8-dihe-out -80.31, 9.26 APE8-rot-na 299.8 APE67-dihe-out -97.29, 28.98 -67.31, 132.23 APE12-dist-na 9.833 APE11-dist-na 11.542 APE10-dist-na 15.898 APE9-dist-out 12.889 W659A,W777A,F794H None None XRAY 2.55 0.211 0.258 A 277 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5wim Homo sapiens TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WINA O60674 536 809 1132.0 SKE:901 Type1 Pseudo DFGin 7.28 13.79 None -75.17, 174.41 -74.13, 155.6 -73.15, -17.87 26.75, 146.64 81.14, -159.91 out-na out 10.815 Saltbr-na 999.0 HRD-in -80.84, -67.43 99.6, -2.16 na-out-out SNCaoo out-out ActLoopNT-out 9.554 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.26, -35.02 APE9-dihe-out -59.2, -25.51 APE8-dihe-out -88.93, -4.07 APE8-rot-na 287.0 APE67-dihe-out -96.98, 26.41 -56.71, 138.03 APE12-dist-na 9.565 APE11-dist-na 11.636 APE10-dist-na 16.025 APE9-dist-out 12.369 W659A,W777A,F794H None None XRAY 2.38 0.221 0.244 A 277 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5win Homo sapiens TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5USZA O60674 537 808 1132.0 SKE:901 Type1 Pseudo DFGin 7.147 13.166 None -89.06, 179.4 -74.28, 155.49 -78.9, -12.42 30.8, 143.13 73.21, -171.41 in-na in 9.349 Saltbr-na 999.0 HRD-in -84.39, -62.72 100.4, -8.06 na-out-out SNCaoo out-out ActLoopNT-out 9.803 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.11, -40.08 APE9-dihe-out -63.02, -23.47 APE8-dihe-out -87.07, 3.62 APE8-rot-na 290.38 APE67-dihe-out -103.08, 29.45 -63.02, 136.82 APE12-dist-na 10.118 APE11-dist-na 11.607 APE10-dist-na 16.233 APE9-dist-out 12.889 W659A,W777A,F794H None None XRAY 2.103 0.174 0.224 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5usz Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT0A O60674 537 808 1132.0 35R:903 Type1 Pseudo DFGin 7.594 13.572 None -93.9, 174.39 -69.93, 155.11 -74.3, -13.06 28.06, 143.5 77.21, -173.63 in-na in 9.939 Saltbr-na 999.0 HRD-in -83.57, -61.23 99.02, -12.98 na-out-out SNCaoo out-out ActLoopNT-out 9.966 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.47, -40.74 APE9-dihe-out -59.34, -26.03 APE8-dihe-out -86.35, 4.34 APE8-rot-na 287.5 APE67-dihe-out -101.06, 28.12 -64.23, 136.97 APE12-dist-na 10.005 APE11-dist-na 11.478 APE10-dist-na 16.135 APE9-dist-out 12.932 W659A,W777A,F794H None None XRAY 2.102 0.171 0.226 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5ut0 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT1A O60674 537 808 1132.0 7DZ:905 Type1 Pseudo DFGin 7.378 13.464 None -94.09, -179.69 -75.66, 158.87 -74.76, -6.96 27.15, 144.11 69.28, -174.72 in-na in 9.696 Saltbr-na 999.0 HRD-in -82.87, -62.64 95.48, -12.09 na-out-out SNCaoo out-out ActLoopNT-out 9.812 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.26, -38.46 APE9-dihe-out -62.2, -22.99 APE8-dihe-out -88.42, 4.71 APE8-rot-na 293.57 APE67-dihe-out -104.03, 27.01 -63.75, 135.14 APE12-dist-na 10.11 APE11-dist-na 11.644 APE10-dist-na 16.21 APE9-dist-out 12.883 W659A,W777A,F794H None None XRAY 1.95 0.165 0.202 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5ut1 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT2A O60674 536 808 1132.0 3YT:903 Type1 Pseudo DFGin 7.127 13.312 None -90.0, 179.18 -75.04, 157.7 -78.17, -8.03 29.61, 139.64 71.77, -178.13 in-na in 9.488 Saltbr-na 999.0 HRD-in -87.63, -60.17 95.16, -5.73 na-out-out SNCaoo out-out ActLoopNT-out 9.87 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.9, -38.59 APE9-dihe-out -61.51, -24.95 APE8-dihe-out -88.74, 4.33 APE8-rot-na 288.64 APE67-dihe-out -101.61, 25.26 -63.02, 138.09 APE12-dist-na 10.014 APE11-dist-na 11.555 APE10-dist-na 16.157 APE9-dist-out 12.879 W659A,W777A,F794H None None XRAY 1.75 0.163 0.201 A 289 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5ut2 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT3A O60674 537 808 1132.0 IK1:901 Type1 Pseudo DFGin 7.268 13.402 None -92.6, 177.07 -71.65, 158.85 -79.65, -10.03 26.8, 143.01 73.38, -177.18 in-na in 9.682 Saltbr-na 999.0 HRD-in -85.94, -61.54 97.51, -8.49 na-out-out SNCaoo out-out ActLoopNT-out 10.02 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.63, -39.44 APE9-dihe-out -66.05, -19.54 APE8-dihe-out -89.06, 2.9 APE8-rot-na 290.51 APE67-dihe-out -104.18, 27.32 -64.34, 136.22 APE12-dist-na 9.99 APE11-dist-na 11.578 APE10-dist-na 16.192 APE9-dist-out 12.996 W659A,W777A,F794H None None XRAY 1.501 0.156 0.17 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5ut3 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT4A O60674 537 809 1132.0 DQX:901 Type1 Pseudo DFGin 7.46 13.285 None -91.51, 174.25 -72.2, 155.17 -81.53, -6.98 30.25, 144.04 71.5, -173.67 in-na in 9.739 Saltbr-na 999.0 HRD-in -82.44, -62.81 97.57, -6.96 na-out-out SNCaoo out-out ActLoopNT-out 9.595 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.04, -37.57 APE9-dihe-out -62.17, -24.8 APE8-dihe-out -89.02, 2.73 APE8-rot-na 291.23 APE67-dihe-out -103.04, 31.05 -61.52, 137.36 APE12-dist-na 9.874 APE11-dist-na 11.628 APE10-dist-na 16.146 APE9-dist-out 12.746 W659A,W777A,F794H None None XRAY 2.0 0.18 0.22 A 289 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5ut4 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT5A O60674 537 808 1132.0 2HB:905 Type1 Pseudo DFGin 7.189 13.293 None -93.16, 174.58 -69.71, 153.91 -76.54, -10.06 29.7, 141.93 72.88, -178.86 in-na in 9.823 Saltbr-na 999.0 HRD-in -86.78, -65.09 96.66, -4.13 na-out-out SNCaoo out-out ActLoopNT-out 9.892 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.35, -36.77 APE9-dihe-out -64.06, -22.66 APE8-dihe-out -88.95, 4.87 APE8-rot-na 294.92 APE67-dihe-out -99.37, 27.39 -66.22, 138.89 APE12-dist-na 10.066 APE11-dist-na 11.654 APE10-dist-na 16.264 APE9-dist-out 12.825 W659A,W777A,F794H None None XRAY 1.9 0.162 0.201 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5ut5 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT6A O60674 537 808 1132.0 8MY:901 Type1 Pseudo DFGin 7.811 13.383 None -94.36, -179.3 -74.79, 159.2 -78.43, -9.68 26.67, 142.51 69.48, -170.15 in-na in 9.762 Saltbr-na 999.0 HRD-in -88.85, -58.65 93.81, -8.0 na-out-out SNCaoo out-out ActLoopNT-out 9.89 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.58, -38.89 APE9-dihe-out -63.87, -22.26 APE8-dihe-out -88.04, 3.04 APE8-rot-na 294.63 APE67-dihe-out -105.83, 26.71 -62.56, 137.4 APE12-dist-na 10.047 APE11-dist-na 11.672 APE10-dist-na 16.237 APE9-dist-out 13.024 W659A,W777A,F794H None None XRAY 1.645 0.169 0.206 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5ut6 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6BRWA O60674 537 808 1132.0 5BS:901 Type1 Pseudo DFGin 7.705 13.379 None -93.41, 174.89 -67.04, 156.04 -83.01, 0.59 33.82, 139.96 67.03, -167.12 in-na in 9.67 Saltbr-na 999.0 HRD-in -76.15, -62.39 95.18, -6.76 na-out-out SNCaoo out-out ActLoopNT-out 9.346 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -74.9, -35.05 APE9-dihe-out -58.77, -25.82 APE8-dihe-out -90.17, 2.34 APE8-rot-na 284.96 APE67-dihe-out -99.82, 21.48 -62.86, 134.79 APE12-dist-na 9.991 APE11-dist-na 11.563 APE10-dist-na 16.181 APE9-dist-out 12.811 W659A,W777A,F794H None None XRAY 2.031 0.197 0.25 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6brw Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6BS0A O60674 537 808 1132.0 E4V:901 Type1 Pseudo DFGin 7.08 13.256 None -88.58, 177.61 -73.17, 156.09 -79.5, -8.28 28.34, 142.63 71.71, -176.36 in-na in 9.568 Saltbr-na 999.0 HRD-in -86.4, -62.0 95.3, -5.83 na-out-out SNCaoo out-out ActLoopNT-out 9.904 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.75, -38.73 APE9-dihe-out -60.18, -24.31 APE8-dihe-out -91.13, 4.36 APE8-rot-na 292.13 APE67-dihe-out -103.61, 24.99 -63.19, 136.77 APE12-dist-na 10.05 APE11-dist-na 11.629 APE10-dist-na 16.231 APE9-dist-out 12.93 W659A,W777A,F794H None None XRAY 1.541 0.162 0.195 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6bs0 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6BSSA O60674 537 808 1132.0 4SP:902 Type1 Pseudo DFGin 7.568 13.511 None -92.12, 176.26 -71.33, 155.06 -76.95, -9.06 29.95, 143.27 73.96, -170.06 in-na in 9.688 Saltbr-na 999.0 HRD-in -85.06, -63.73 98.07, -5.96 na-out-out SNCaoo out-out ActLoopNT-out 9.888 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.01, -35.23 APE9-dihe-out -61.99, -26.69 APE8-dihe-out -86.73, 3.75 APE8-rot-na 289.32 APE67-dihe-out -100.38, 23.52 -64.28, 136.45 APE12-dist-na 9.985 APE11-dist-na 11.551 APE10-dist-na 16.187 APE9-dist-out 12.882 W659A,W777A,F794H None None XRAY 2.1 0.194 0.235 A 289 271 1 0 0 0 [[545, 807], [849, 1125]] 2.0 6bss Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6M9HA O60674 536 808 1132.0 J9D:901 Type1 Pseudo DFGin 7.866 13.199 None -93.81, -179.33 -75.36, 156.59 -79.44, -11.27 28.67, 140.35 75.69, -170.14 in-na in 9.789 Saltbr-na 999.0 HRD-in -82.1, -57.99 92.46, -9.79 na-out-out SNCaoo out-out ActLoopNT-out 9.792 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.63, -41.5 APE9-dihe-out -66.06, -19.63 APE8-dihe-out -87.45, 2.93 APE8-rot-na 291.17 APE67-dihe-out -101.95, 25.55 -63.43, 136.79 APE12-dist-na 10.049 APE11-dist-na 11.59 APE10-dist-na 16.207 APE9-dist-out 12.959 W659A,W777A,F794H None None XRAY 1.79 0.172 0.206 A 289 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6m9h Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OAVA O60674 537 808 1132.0 M3A:901 Type1 Pseudo DFGin 7.112 13.039 None -89.82, 175.57 -71.85, 155.92 -76.93, -12.28 28.1, 145.13 74.45, -170.6 in-na in 9.815 Saltbr-na 999.0 HRD-in -81.92, -60.26 97.52, -13.09 na-out-out SNCaoo out-out ActLoopNT-out 9.649 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.27, -33.28 APE9-dihe-out -70.41, -15.65 APE8-dihe-out -94.12, 2.48 APE8-rot-na 295.49 APE67-dihe-out -103.53, 27.01 -62.67, 134.47 APE12-dist-na 9.928 APE11-dist-na 11.491 APE10-dist-na 16.083 APE9-dist-out 12.706 W659A,W777A,F794H None None XRAY 1.939 0.202 0.236 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6oav Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OBBA O60674 537 808 1132.0 M3Y:901 Type1 Pseudo DFGin 7.342 13.234 None -84.34, 177.39 -74.24, 159.35 -79.81, -16.97 27.48, 144.61 78.13, -168.92 out-na out 10.134 Saltbr-na 999.0 HRD-in -82.45, -60.11 93.59, -13.21 na-out-out SNCaoo out-out ActLoopNT-out 9.734 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.05, -38.37 APE9-dihe-out -67.29, -18.2 APE8-dihe-out -91.42, 5.55 APE8-rot-na 289.4 APE67-dihe-out -101.89, 28.31 -66.13, 136.22 APE12-dist-na 9.976 APE11-dist-na 11.438 APE10-dist-na 16.1 APE9-dist-out 12.826 W659A,W777A,F794H None None XRAY 1.904 0.197 0.225 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6obb Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OBFA O60674 537 808 1132.0 M4G:902 Type1 Pseudo DFGin 5.802 13.575 None -75.4, 175.18 -69.61, 155.48 -61.14, -31.23 333.27, 38.74 78.42, -174.91 out-na out 11.73 Saltbr-na 999.0 HRD-in -79.03, -58.03 90.73, -7.36 na-out-out SNCaoo out-out ActLoopNT-out 9.126 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.35, -37.95 APE9-dihe-out -66.08, -20.0 APE8-dihe-out -89.74, 3.4 APE8-rot-na 287.78 APE67-dihe-out -103.65, 28.29 -65.52, 135.12 APE12-dist-na 9.876 APE11-dist-na 11.414 APE10-dist-na 16.018 APE9-dist-out 12.52 W659A,W777A,F794H None None XRAY 1.71 0.199 0.222 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6obf Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OBLA O60674 537 808 1132.0 M4P:901 Type1 Pseudo DFGin 6.131 13.618 None -84.06, 175.88 -72.71, 160.31 -68.63, -25.11 336.97, 36.63 73.61, -166.98 out-na out 11.6 Saltbr-na 999.0 HRD-in -78.47, -60.55 94.84, -3.9 na-out-out SNCaoo out-out ActLoopNT-out 9.075 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.59, -34.77 APE9-dihe-out -65.45, -25.46 APE8-dihe-out -86.12, 6.91 APE8-rot-na 289.77 APE67-dihe-out -101.28, 22.22 -64.94, 134.76 APE12-dist-na 9.865 APE11-dist-na 11.395 APE10-dist-na 16.044 APE9-dist-out 12.711 W659A,W777A,F794H None None XRAY 2.061 0.2 0.239 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6obl Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6OCCA O60674 537 808 1132.0 M57:1002 Type1 Pseudo DFGin 6.062 13.569 None -84.33, 174.58 -71.42, 156.44 -66.05, -27.79 338.24, 34.72 78.91, -171.69 out-na out 11.717 Saltbr-na 999.0 HRD-in -79.87, -63.55 97.41, -5.73 na-out-out SNCaoo out-out ActLoopNT-out 9.26 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.17, -40.0 APE9-dihe-out -66.58, -22.02 APE8-dihe-out -86.2, 2.55 APE8-rot-na 295.02 APE67-dihe-out -102.04, 27.42 -65.31, 136.06 APE12-dist-na 9.937 APE11-dist-na 11.412 APE10-dist-na 16.0 APE9-dist-out 12.434 W659A,W777A,F794H None None XRAY 2.03 0.227 0.272 A 289 268 4 0 0 0 [[545, 807], [849, 1125]] 2.0 6occ Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6XJKA O60674 539 807 1132.0 V4D:901 Type1 Pseudo DFGin 7.086 13.11 None -82.39, -178.8 -73.6, 159.61 -82.47, -18.87 26.68, 148.75 79.98, -172.67 out-na out 10.943 Saltbr-na 999.0 HRD-in -78.39, -61.79 94.59, -5.62 na-out-out SNCaoo out-out ActLoopNT-out 9.177 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.63, -38.8 APE9-dihe-out -69.88, -19.28 APE8-dihe-out -90.06, 4.72 APE8-rot-na 291.97 APE67-dihe-out -100.24, 24.73 -62.96, 137.34 APE12-dist-na 9.833 APE11-dist-na 11.651 APE10-dist-na 16.135 APE9-dist-out 12.537 W659A,W777A,F794H None None XRAY 2.024 0.229 0.273 A 289 265 4 0 0 0 [[545, 807], [849, 1125]] 2.0 6xjk Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7JYOA O60674 539 808 1132.0 VPS:901 Type1 Pseudo DFGin 7.313 13.265 None -88.9, -179.5 -76.4, 155.67 -78.17, -11.76 25.61, 146.28 75.85, -168.38 in-na in 9.94 Saltbr-na 999.0 HRD-in -78.1, -62.53 100.04, -11.32 na-out-out SNCaoo out-out ActLoopNT-out 9.47 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.05, -35.44 APE9-dihe-out -67.28, -21.98 APE8-dihe-out -89.32, 5.73 APE8-rot-na 292.48 APE67-dihe-out -104.2, 24.04 -63.78, 134.25 APE12-dist-na 10.006 APE11-dist-na 11.495 APE10-dist-na 16.072 APE9-dist-out 12.671 W659A,W777A,F794H None None XRAY 2.161 0.188 0.246 A 289 270 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7jyo Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7JYQA O60674 537 808 1132.0 VPJ:902 Type1 Pseudo DFGin 7.645 13.005 None -92.98, -175.16 -77.54, 154.64 -78.8, -12.58 29.28, 143.4 74.39, -171.67 out-na out 13.073 Saltbr-na 999.0 HRD-in -86.04, -59.14 96.24, -12.09 na-out-out SNCaoo out-out ActLoopNT-out 9.812 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.31, -38.61 APE9-dihe-out -62.73, -23.3 APE8-dihe-out -89.27, 2.43 APE8-rot-na 292.66 APE67-dihe-out -102.33, 26.3 -62.62, 135.22 APE12-dist-na 10.015 APE11-dist-na 11.568 APE10-dist-na 16.168 APE9-dist-out 12.866 W659A,W777A,F794H None None XRAY 1.859 0.181 0.221 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7jyq Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7SZWA O60674 537 808 1132.0 DVY:901 Type1 Pseudo DFGin 6.452 13.26 None -82.57, 177.58 -73.21, 157.07 -69.74, -29.09 341.81, 33.15 77.93, -172.46 out-na out 12.306 Saltbr-na 999.0 HRD-in -80.57, -59.83 95.34, -11.68 na-out-out SNCaoo out-out ActLoopNT-out 9.255 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.83, -37.85 APE9-dihe-out -63.74, -25.15 APE8-dihe-out -91.51, 8.03 APE8-rot-na 297.58 APE67-dihe-out -99.24, 24.79 -65.54, 137.42 APE12-dist-na 9.926 APE11-dist-na 11.427 APE10-dist-na 16.064 APE9-dist-out 12.408 W659A,W777A,F794H None None XRAY 1.906 0.195 0.226 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7szw Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7T0PA O60674 536 808 1132.0 E3W:901 Type1 Pseudo DFGin 5.536 13.453 None -71.36, 169.62 -64.37, 154.19 -64.4, -34.91 335.03, 35.41 82.73, -164.25 out-na out 11.625 Saltbr-na 999.0 HRD-in -78.49, -60.16 92.47, -7.36 na-out-out SNCaoo out-out ActLoopNT-out 9.411 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.7, -41.68 APE9-dihe-out -61.62, -27.73 APE8-dihe-out -89.13, 13.42 APE8-rot-na 292.46 APE67-dihe-out -104.69, 27.09 -67.15, 136.9 APE12-dist-na 10.128 APE11-dist-na 11.477 APE10-dist-na 16.172 APE9-dist-out 12.825 W659A,W777A,F794H None None XRAY 2.04 0.197 0.247 A 289 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7t0p Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7T0PB O60674 536 808 1132.0 E3W:901 Type1 Pseudo DFGin 5.584 13.375 None -73.4, 171.14 -67.99, 156.9 -65.04, -35.98 333.3, 36.74 84.58, -160.86 out-na out 11.675 Saltbr-na 999.0 HRD-in -82.44, -59.87 91.7, -5.68 na-out-out SNCaoo out-out ActLoopNT-out 9.525 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.77, -34.38 APE9-dihe-out -70.23, -20.91 APE8-dihe-out -95.01, 13.79 APE8-rot-na 294.77 APE67-dihe-out -106.03, 28.99 -67.37, 133.92 APE12-dist-na 10.083 APE11-dist-na 11.624 APE10-dist-na 16.26 APE9-dist-out 12.957 W659A,W777A,F794H None None XRAY 2.04 0.197 0.247 B 289 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7t0p Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 7T1TA O60674 536 809 1132.0 E8I:901 Type1 Pseudo DFGin 7.074 13.199 None -85.56, -179.34 -72.27, 154.59 -78.75, -8.81 22.02, 154.16 65.96, -165.49 out-na out 10.812 Saltbr-na 999.0 HRD-in -83.69, -59.16 91.95, -7.4 na-out-out SNCaoo out-out ActLoopNT-out 9.73 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.83, -40.65 APE9-dihe-out -65.84, -24.48 APE8-dihe-out -87.52, 8.41 APE8-rot-na 292.81 APE67-dihe-out -105.4, 28.45 -65.24, 133.84 APE12-dist-na 9.948 APE11-dist-na 11.612 APE10-dist-na 16.182 APE9-dist-out 12.938 W659A,W777A,F794H None None XRAY 2.08 0.183 0.228 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 7t1t Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B9HA O60674 536 809 1132.0 Q7F:901 Type1 Pseudo DFGin 6.01 13.307 None -84.93, -177.89 -74.12, 157.3 -67.76, -31.57 343.4, 32.07 81.26, -168.8 out-na out 12.097 Saltbr-na 999.0 HRD-in -82.25, -60.3 91.76, -5.32 na-out-out SNCaoo out-out ActLoopNT-out 9.143 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.85, -39.85 APE9-dihe-out -62.27, -26.85 APE8-dihe-out -86.04, 1.76 APE8-rot-na 292.25 APE67-dihe-out -100.68, 23.58 -62.84, 136.16 APE12-dist-na 9.712 APE11-dist-na 11.434 APE10-dist-na 15.933 APE9-dist-out 12.428 W659A,W777A,F794H None None XRAY 1.5 0.182 0.208 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8b9h Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8BA3A O60674 536 812 1132.0 Q8U:60901 Type1 Pseudo DFGin 7.945 13.708 None -77.62, 172.89 -67.28, 156.81 -77.15, -9.78 24.71, 146.25 70.37, -168.01 out-na out 10.581 Saltbr-na 999.0 HRD-in -73.02, -63.41 91.28, -5.41 na-out-out SNCaoo out-out ActLoopNT-out 8.832 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.97, -37.88 APE9-dihe-out -69.87, -18.94 APE8-dihe-out -88.79, 5.92 APE8-rot-na 290.58 APE67-dihe-out -110.89, 28.54 -69.8, 129.69 APE12-dist-na 10.041 APE11-dist-na 11.89 APE10-dist-na 16.425 APE9-dist-out 12.509 W659A,W777A,F794H None None XRAY 1.4 0.175 0.197 A 289 277 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8ba3 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8EX0A O60674 536 808 1132.0 AQG:901 Type1 Pseudo DFGin 7.412 13.402 None -87.55, 174.91 -71.81, 159.18 -77.63, -11.45 24.29, 145.18 73.87, -172.91 in-na in 9.643 Saltbr-na 999.0 HRD-in -81.87, -61.41 94.19, -7.67 na-out-out SNCaoo out-out ActLoopNT-out 9.608 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.42, -37.24 APE9-dihe-out -64.33, -22.0 APE8-dihe-out -89.33, 0.5 APE8-rot-na 287.44 APE67-dihe-out -103.06, 26.06 -59.07, 135.76 APE12-dist-na 9.888 APE11-dist-na 11.561 APE10-dist-na 16.136 APE9-dist-out 12.686 W659A,W777A,F794H None None XRAY 1.85 0.179 0.228 A 289 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8ex0 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8EX1A O60674 537 808 1132.0 AD5:901 Type1 Pseudo DFGin 7.282 13.57 None -94.73, 174.88 -71.85, 156.73 -78.3, -7.64 23.96, 145.89 75.85, -176.26 in-na in 9.851 Saltbr-na 999.0 HRD-in -83.17, -61.66 95.43, -4.68 na-out-out SNCaoo out-out ActLoopNT-out 9.745 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.78, -38.61 APE9-dihe-out -63.17, -26.48 APE8-dihe-out -86.79, 6.17 APE8-rot-na 291.87 APE67-dihe-out -106.59, 26.74 -65.58, 134.04 APE12-dist-na 9.851 APE11-dist-na 11.55 APE10-dist-na 16.057 APE9-dist-out 12.773 W659A,W777A,F794H None None XRAY 1.5 0.169 0.191 A 289 272 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8ex1 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8EX2A O60674 536 808 1132.0 Q2Q:901 Type1 Pseudo DFGin 7.683 13.39 None -89.91, 173.83 -74.44, 158.35 -75.25, -10.25 27.64, 142.49 74.64, -169.3 in-na in 9.726 Saltbr-na 999.0 HRD-in -84.46, -65.65 96.23, -6.71 na-out-out SNCaoo out-out ActLoopNT-out 9.561 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.11, -41.46 APE9-dihe-out -59.07, -26.71 APE8-dihe-out -87.22, 3.02 APE8-rot-na 287.18 APE67-dihe-out -104.5, 26.8 -63.95, 134.55 APE12-dist-na 9.976 APE11-dist-na 11.51 APE10-dist-na 16.131 APE9-dist-out 12.634 W659A,W777A,F794H None None XRAY 1.9 0.172 0.203 A 289 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8ex2 Homo sapiens TYR_JAK2-1_HUMAN TYR 2.7e-64 222.9 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 9ND5A O60674 536 809 1132.0 A1BXA:901 Type1 Pseudo DFGin 7.197 13.436 None -78.37, 174.28 -71.06, 155.85 -82.01, -13.03 28.16, 149.91 71.45, -157.96 out-na out 10.377 Saltbr-na 999.0 HRD-in -81.65, -70.18 103.7, -2.47 na-out-out SNCaoo out-out ActLoopNT-out 9.473 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -76.62, -29.08 APE9-dihe-out -76.41, -20.7 APE8-dihe-out -84.83, 10.94 APE8-rot-na 287.64 APE67-dihe-out -108.27, 36.81 -81.67, 130.11 APE12-dist-na 9.653 APE11-dist-na 11.441 APE10-dist-na 16.018 APE9-dist-out 12.453 None None None XRAY 2.4 0.214 0.278 A 280 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 9nd5 Homo sapiens TYR_JAK2-1_HUMAN TYR 2.8e-64 222.8 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 9ND3A O60674 536 808 1132.0 A1BW6:901 Type1 Pseudo DFGin 5.996 13.116 None -64.1, 173.67 -70.95, 163.72 -78.01, -24.74 341.83, 32.74 77.82, -165.18 out-na out 11.374 Saltbr-na 999.0 HRD-in -84.19, -60.63 89.29, -1.33 na-out-out SNCaoo out-out ActLoopNT-out 9.195 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.37, -39.11 APE9-dihe-out -58.8, -29.7 APE8-dihe-out -87.32, 4.81 APE8-rot-na 289.91 APE67-dihe-out -104.68, 28.28 -65.86, 133.14 APE12-dist-na 9.657 APE11-dist-na 11.461 APE10-dist-na 16.002 APE9-dist-out 12.276 None None None XRAY 1.62 0.189 0.22 A 283 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 9nd3 Homo sapiens TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR PTK7 PTK7_HUMAN 6VG3A Q13308 788 1064 1070.0 No_ligand No_ligand Pseudo DFGout 13.072 8.61 BBAminus -132.34, -161.44 -155.86, 92.46 -97.69, -48.83 283.16, 84.9 56.84, 47.43 in-in in 7.577 Saltbr-in 2.798 HRD-in -72.42, -53.38 81.44, -12.12 in-out-in SNCioi out-in ActLoopNT-out 19.184 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.31, 104.46 APE9-dihe-in -109.64, 148.6 APE8-dihe-in -79.12, 64.71 APE8-rot-na 28.7 APE67-dihe-in -66.82, -5.68 -34.68, -60.13 APE12-dist-na 18.612 APE11-dist-na 14.329 APE10-dist-na 9.652 APE9-dist-in 7.427 None None None XRAY 1.95 0.192 0.244 A 296 277 0 0 0 0 [[796, 1063]] 1.0 6vg3 Homo sapiens TYR_PTK7_HUMAN TYR 8.5e-87 296.7 4 259 256 947 948 949 951 953 830 846 850 927 929 928 930 988 976 971 970 969 968 967 966 965 876 Inactive tyrosine-protein kinase 7
TYR PTK7 PTK7_HUMAN 6VG3B Q13308 788 1066 1070.0 No_ligand No_ligand Pseudo DFGout 13.088 8.38 BBAminus -131.68, -160.87 -157.21, 94.94 -101.44, -43.98 278.12, 86.39 51.45, 55.01 in-in in 7.598 Saltbr-in 2.688 HRD-in -63.01, -52.6 78.41, -7.98 in-out-in SNCioi out-in ActLoopNT-out 19.006 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.07, 113.56 APE9-dihe-in -113.29, 141.65 APE8-dihe-in -78.24, 63.62 APE8-rot-na 29.31 APE67-dihe-in -67.88, -8.76 -38.92, -54.25 APE12-dist-na 17.367 APE11-dist-na 13.49 APE10-dist-na 8.814 APE9-dist-in 7.315 None None None XRAY 1.95 0.192 0.244 B 296 279 0 0 0 0 [[796, 1063]] 1.0 6vg3 Homo sapiens TYR_PTK7_HUMAN TYR 8.5e-87 296.7 4 259 256 947 948 949 951 953 830 846 850 927 929 928 930 988 976 971 970 969 968 967 966 965 876 Inactive tyrosine-protein kinase 7
TYR PTK7 PTK7_HUMAN 6VG3C Q13308 789 1063 1070.0 No_ligand No_ligand Pseudo DFGout 13.009 8.498 BBAminus -129.46, -163.85 -155.05, 92.33 -97.04, -44.83 285.72, 96.38 51.74, 52.51 in-in in 7.676 Saltbr-in 2.685 HRD-in -64.52, -54.07 79.6, -11.28 in-out-in SNCioi out-in ActLoopNT-out 18.772 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.66, 107.88 APE9-dihe-in -124.36, 144.24 APE8-dihe-in -79.62, 62.86 APE8-rot-na 27.94 APE67-dihe-in -70.37, -4.0 -30.14, -56.43 APE12-dist-na 18.544 APE11-dist-na 15.16 APE10-dist-na 9.995 APE9-dist-in 7.27 None None None XRAY 1.95 0.192 0.244 C 296 265 10 0 0 0 [[796, 1063]] 1.0 6vg3 Homo sapiens TYR_PTK7_HUMAN TYR 8.5e-87 296.7 4 259 256 947 948 949 951 953 830 846 850 927 929 928 930 988 976 971 970 969 968 967 966 965 876 Inactive tyrosine-protein kinase 7
TYR ROR1 ROR1_HUMAN 6TU9A Q01973 460 749 937.0 0LI:801 Type1 Pseudo None 999.0 999.0 None -143.45, 175.76 -148.29, 81.04 -104.43, 119.64 999.0, 999.0 -53.65, -7.79 in-in in 8.227 Saltbr-in 2.725 HRD-in -69.35, -57.72 81.6, -11.35 in-out-in SNCioi out-in ActLoopNT-out 15.395 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -88.59, 129.49 APE9-dihe-in -125.15, 133.19 APE8-dihe-in -78.4, 68.8 APE8-rot-na 36.93 APE67-dihe-in -68.17, -18.18 -55.42, -35.07 APE12-dist-na 999.0 APE11-dist-na 15.69 APE10-dist-na 11.605 APE9-dist-in 6.992 None None None XRAY 1.94 0.21 0.241 A 306 268 22 0 0 4 [[473, 748]] 1.0 6tu9 Homo sapiens TYR_ROR1_HUMAN TYR 1.2e-94 322.4 2 260 259 632 633 634 636 638 506 523 527 612 614 613 615 674 662 657 656 655 654 653 652 651 553 Inactive tyrosine-protein kinase transmembrane receptor ROR1
TYR ROR1 ROR1_HUMAN 6TU9B Q01973 465 750 937.0 0LI:801 Type1 Pseudo None 999.0 999.0 None -143.03, 176.7 -144.7, 81.77 -85.65, -31.03 999.0, 999.0 92.49, -44.82 in-in in 8.283 Saltbr-in 2.974 HRD-in -64.86, -61.91 82.91, -9.99 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.96, 129.63 APE9-dihe-in -119.15, 127.45 APE8-dihe-in -76.72, 68.52 APE8-rot-na 33.66 APE67-dihe-in -67.05, -20.69 -57.04, -32.64 APE12-dist-na 17.025 APE11-dist-na 15.144 APE10-dist-na 11.197 APE9-dist-in 6.97 None None None XRAY 1.94 0.21 0.241 B 306 261 25 0 0 2 [[473, 748]] 1.0 6tu9 Homo sapiens TYR_ROR1_HUMAN TYR 1.2e-94 322.4 2 260 259 632 633 634 636 638 506 523 527 612 614 613 615 674 662 657 656 655 654 653 652 651 553 Inactive tyrosine-protein kinase transmembrane receptor ROR1
TYR ROR2 ROR2_HUMAN 3ZZWA Q01974 466 750 943.0 No_ligand No_ligand Pseudo DFGinter 10.345 8.07 None -96.3, 113.42 -93.32, 36.02 -147.08, 160.59 50.4, 103.61 174.45, -162.31 in-out in 8.469 Saltbr-out 4.596 HRD-in -47.14, -51.88 77.11, -23.02 out-out-in SNCooi out-in ActLoopNT-out 17.444 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.81, 114.23 APE9-dihe-in -109.27, 120.13 APE8-dihe-in -82.4, 68.78 APE8-rot-na 28.79 APE67-dihe-in -64.86, -16.77 -44.26, -50.32 APE12-dist-na 13.627 APE11-dist-na 12.242 APE10-dist-na 7.628 APE9-dist-in 7.665 None None None XRAY 2.9 0.19 0.247 A 289 269 16 0 0 0 [[473, 748]] 1.0 3zzw Homo sapiens TYR_ROR2_HUMAN TYR 5.3e-91 310.4 2 260 259 632 633 634 636 638 507 524 528 612 614 613 615 674 662 657 656 655 654 653 652 651 554 Tyrosine-protein kinase transmembrane receptor ROR2
TYR ROR2 ROR2_HUMAN 4GT4A Q01974 464 751 943.0 No_ligand No_ligand Pseudo DFGinter 9.614 6.483 None -93.67, 118.8 -119.64, 62.63 -106.27, -3.3 278.25, 67.29 61.48, 39.98 in-out in 8.533 Saltbr-out 3.871 HRD-out -75.16, 142.52 -112.65, 2.81 out-out-in SNCooi out-in ActLoopNT-out 16.314 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.46, 127.32 APE9-dihe-in -119.05, 136.77 APE8-dihe-in -80.2, 67.59 APE8-rot-na 30.63 APE67-dihe-in -67.7, -19.84 -54.55, -34.96 APE12-dist-na 15.894 APE11-dist-na 12.718 APE10-dist-na 10.239 APE9-dist-in 6.747 None None None XRAY 2.406 0.179 0.205 A 308 274 14 0 0 0 [[473, 748]] 1.0 4gt4 Homo sapiens TYR_ROR2_HUMAN TYR 6.7e-91 310.1 2 260 259 632 633 634 636 638 507 524 528 612 614 613 615 674 662 657 656 655 654 653 652 651 554 Tyrosine-protein kinase transmembrane receptor ROR2
TYR ROR2 ROR2_HUMAN 4GT4B Q01974 464 752 943.0 No_ligand No_ligand Pseudo DFGinter 10.193 7.582 None -91.01, 100.94 -99.91, 70.26 -110.46, -11.91 297.81, 174.51 61.14, 43.64 in-in in 8.881 Saltbr-in 2.975 HRD-in -71.57, -49.3 78.13, -12.79 in-out-in SNCioi out-in ActLoopNT-out 16.141 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.88, 120.55 APE9-dihe-in -112.46, 137.59 APE8-dihe-in -79.18, 69.28 APE8-rot-na 29.96 APE67-dihe-in -69.15, -20.22 -53.97, -34.39 APE12-dist-na 15.711 APE11-dist-na 12.448 APE10-dist-na 10.062 APE9-dist-in 6.755 None None None XRAY 2.406 0.179 0.205 B 308 273 16 0 0 0 [[473, 748]] 1.0 4gt4 Homo sapiens TYR_ROR2_HUMAN TYR 6.7e-91 310.1 2 260 259 632 633 634 636 638 507 524 528 612 614 613 615 674 662 657 656 655 654 653 652 651 554 Tyrosine-protein kinase transmembrane receptor ROR2
TYR ROR2 ROR2_HUMAN 3ZZWB Q01974 466 750 943.0 No_ligand No_ligand Pseudo DFGout 16.98 12.863 None -137.59, -157.96 -151.06, 33.97 -68.88, -19.62 62.12, 76.59 -42.22, -63.32 in-out in 8.671 Saltbr-out 5.013 HRD-in -47.64, -52.27 76.28, -20.82 out-out-in SNCooi out-in ActLoopNT-out 17.908 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.84, 114.99 APE9-dihe-in -110.43, 119.46 APE8-dihe-in -82.84, 69.13 APE8-rot-na 28.38 APE67-dihe-in -65.02, -16.31 -43.72, -51.28 APE12-dist-na 13.216 APE11-dist-na 11.513 APE10-dist-na 6.081 APE9-dist-in 7.603 None None None XRAY 2.9 0.19 0.247 B 289 265 20 0 0 0 [[473, 748]] 1.0 3zzw Homo sapiens TYR_ROR2_HUMAN TYR 5.3e-91 310.4 2 260 259 632 633 634 636 638 507 524 528 612 614 613 615 674 662 657 656 655 654 653 652 651 554 Tyrosine-protein kinase transmembrane receptor ROR2
TYR TYK2-12 TYK2_HUMAN 4OLIA P29597 579 1177 1187.0 2TT:1201,2TT:1202 Allosteric,Type1 Pseudo DFGin 6.584 14.06 BLAminus -112.91, -164.12 51.99, 82.7 -97.25, 13.35 286.86, 70.8 -52.39, -43.72 in-in in 7.973 Saltbr-in 3.587 HRD-in -83.85, -51.17 64.18, 9.79 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.93, 161.16 APE9-dihe-in -150.27, 143.84 APE8-dihe-in -73.85, 77.54 APE8-rot-na 27.48 APE67-dihe-in -66.57, -4.05 -49.5, -43.89 APE12-dist-na 11.713 APE11-dist-na 9.483 APE10-dist-na 10.323 APE9-dist-in 6.04 D1023N None None XRAY 2.8 0.205 0.257 A 645 539 60 0 0 0 [[589, 868], [897, 1171]] 2.0 4oli Homo sapiens TYR_TYK2-12_HUMAN TYR 4.2e-59 483.0 2 260 518 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5C03A P29597 579 869 1187.0 AGS:901 ATPlike Pseudo DFGin 7.384 13.105 None -83.93, 173.19 -65.21, 161.12 -79.17, -4.85 20.2, 153.73 66.68, -148.85 in-na in 9.794 Saltbr-na 999.0 HRD-in -90.34, -65.69 85.25, 3.79 na-out-out SNCaoo out-out ActLoopNT-out 7.833 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.44, -38.84 APE9-dihe-out -63.06, -21.54 APE8-dihe-out -87.7, -1.06 APE8-rot-na 196.81 APE67-dihe-out -97.84, 8.94 -69.26, 133.75 APE12-dist-na 10.117 APE11-dist-na 12.251 APE10-dist-na 16.457 APE9-dist-out 11.202 None None None XRAY 1.9 0.183 0.218 A 342 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 5c03 Homo sapiens TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5C03B P29597 580 870 1187.0 AGS:901 ATPlike Pseudo DFGin 7.517 12.886 None -71.74, 164.11 -66.43, 161.04 -81.86, 0.59 24.73, 148.49 67.14, -147.92 in-na in 9.709 Saltbr-na 999.0 HRD-in -90.78, -63.58 88.98, 2.52 na-out-out SNCaoo out-out ActLoopNT-out 7.957 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.24, -42.55 APE9-dihe-out -56.38, -27.94 APE8-dihe-out -85.13, -4.16 APE8-rot-na 194.3 APE67-dihe-out -97.21, 10.32 -66.64, 134.88 APE12-dist-na 9.635 APE11-dist-na 12.304 APE10-dist-na 16.484 APE9-dist-out 11.221 None None None XRAY 1.9 0.183 0.218 B 342 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 5c03 Homo sapiens TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7AX4A P29597 579 868 1187.0 NM7:2000 Type1 Pseudo DFGin 7.507 12.805 None -76.81, 166.44 -58.43, 152.23 -70.05, -8.8 24.77, 146.14 76.34, -154.15 in-na in 9.556 Saltbr-na 999.0 HRD-in -86.69, -61.89 82.12, 4.68 na-out-out SNCaoo out-out ActLoopNT-out 8.232 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.65, -45.17 APE9-dihe-out -58.59, -27.02 APE8-dihe-out -78.56, -9.63 APE8-rot-na 222.71 APE67-dihe-out -95.98, 6.87 -68.07, 131.63 APE12-dist-na 9.662 APE11-dist-na 12.284 APE10-dist-na 16.464 APE9-dist-out 11.658 None None None XRAY 2.12 0.186 0.229 A 295 261 29 0 0 0 [[589, 868], [897, 1171]] 2.0 7ax4 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7AX4B P29597 579 868 1187.0 NM7:2000 Type1 Pseudo DFGin 7.488 12.776 None -74.88, 165.0 -57.44, 152.12 -71.28, -8.27 25.03, 145.7 75.91, -154.77 in-na in 9.496 Saltbr-na 999.0 HRD-in -85.26, -61.54 83.16, 3.63 na-out-out SNCaoo out-out ActLoopNT-out 8.325 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.51, -41.43 APE9-dihe-out -63.74, -26.18 APE8-dihe-out -77.76, -6.82 APE8-rot-na 221.04 APE67-dihe-out -90.97, 8.23 -71.21, 136.1 APE12-dist-na 9.807 APE11-dist-na 12.32 APE10-dist-na 16.542 APE9-dist-out 11.793 None None None XRAY 2.12 0.186 0.229 B 295 261 29 0 0 0 [[589, 868], [897, 1171]] 2.0 7ax4 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98A P29597 578 867 1187.0 ZRU:901 Type1 Pseudo DFGin 7.353 12.698 None -63.41, 150.46 -40.02, 136.95 -69.11, -5.37 28.88, 139.25 79.24, -154.61 in-na in 9.676 Saltbr-na 999.0 HRD-in -86.71, -58.07 85.92, 3.99 na-out-out SNCaoo out-out ActLoopNT-out 8.115 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.34, -41.36 APE9-dihe-out -63.27, -26.83 APE8-dihe-out -87.06, 1.76 APE8-rot-na 289.42 APE67-dihe-out -101.27, 10.15 -70.05, 135.5 APE12-dist-na 9.77 APE11-dist-na 12.368 APE10-dist-na 16.501 APE9-dist-out 11.633 None None CSO808 XRAY 1.87 0.226 0.274 A 295 256 35 0 0 0 [[589, 868], [897, 1171]] 2.0 8s98 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98B P29597 578 867 1187.0 ZRU:901 Type1 Pseudo DFGin 7.339 12.942 None -54.77, 156.29 -53.9, 146.74 -74.48, -2.14 30.11, 138.2 66.75, -149.92 in-na in 9.696 Saltbr-na 999.0 HRD-in -77.0, -58.39 85.56, 3.19 na-out-out SNCaoo out-out ActLoopNT-out 8.466 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.92, -37.3 APE9-dihe-out -60.59, -30.35 APE8-dihe-out -84.45, -1.45 APE8-rot-na 293.47 APE67-dihe-out -99.24, 10.29 -63.77, 131.59 APE12-dist-na 9.967 APE11-dist-na 12.261 APE10-dist-na 16.539 APE9-dist-out 11.738 None None CSO808 XRAY 1.87 0.226 0.274 B 295 259 32 0 0 0 [[589, 868], [897, 1171]] 2.0 8s98 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98C P29597 578 868 1187.0 ZRU:901 Type1 Pseudo DFGin 7.558 12.819 None -59.14, 154.57 -51.18, 142.9 -77.73, 6.11 31.51, 139.73 67.49, -158.75 in-na in 9.615 Saltbr-na 999.0 HRD-in -81.52, -60.95 90.44, 9.6 na-out-out SNCaoo out-out ActLoopNT-out 8.572 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.87, -38.56 APE9-dihe-out -63.68, -27.1 APE8-dihe-out -84.04, -1.3 APE8-rot-na 288.57 APE67-dihe-out -98.82, 11.75 -65.96, 135.63 APE12-dist-na 9.932 APE11-dist-na 12.277 APE10-dist-na 16.512 APE9-dist-out 11.862 None None CSO808 XRAY 1.87 0.226 0.274 C 295 261 30 0 0 0 [[589, 868], [897, 1171]] 2.0 8s98 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S99A P29597 578 868 1187.0 ZS3:901 Type1 Pseudo DFGin 7.399 12.782 None -62.82, 155.3 -51.38, 147.9 -74.24, -0.55 28.63, 142.53 65.17, -151.12 in-na in 9.659 Saltbr-na 999.0 HRD-in -82.17, -60.98 83.64, 7.23 na-out-out SNCaoo out-out ActLoopNT-out 8.33 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.74, -38.21 APE9-dihe-out -59.13, -29.8 APE8-dihe-out -88.76, 1.4 APE8-rot-na 298.32 APE67-dihe-out -97.29, 12.8 -68.06, 135.28 APE12-dist-na 9.928 APE11-dist-na 12.29 APE10-dist-na 16.586 APE9-dist-out 11.761 None None None XRAY 1.71 0.191 0.225 A 295 261 30 0 0 0 [[589, 868], [897, 1171]] 2.0 8s99 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S99B P29597 579 867 1187.0 ZS3:901 Type1 Pseudo DFGin 7.443 12.614 None -56.5, 153.96 -51.89, 147.7 -74.35, -1.31 29.46, 140.64 65.58, -151.37 in-na in 9.557 Saltbr-na 999.0 HRD-in -80.48, -58.61 84.39, 4.19 na-out-out SNCaoo out-out ActLoopNT-out 8.426 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.04, -40.63 APE9-dihe-out -58.98, -25.02 APE8-dihe-out -89.21, 1.32 APE8-rot-na 294.34 APE67-dihe-out -101.31, 17.67 -66.15, 136.61 APE12-dist-na 9.909 APE11-dist-na 12.186 APE10-dist-na 16.471 APE9-dist-out 11.849 None None None XRAY 1.71 0.191 0.225 B 295 261 29 0 0 0 [[589, 868], [897, 1171]] 2.0 8s99 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S99C P29597 578 867 1187.0 ZS3:901 Type1 Pseudo DFGin 7.462 12.589 None -61.71, 157.01 -52.78, 147.81 -73.85, -0.24 30.37, 137.25 70.68, -153.5 in-na in 9.588 Saltbr-na 999.0 HRD-in -82.08, -63.18 88.21, 6.86 na-out-out SNCaoo out-out ActLoopNT-out 8.173 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.66, -43.16 APE9-dihe-out -54.27, -29.75 APE8-dihe-out -91.84, 3.24 APE8-rot-na 295.26 APE67-dihe-out -102.57, 13.29 -66.4, 134.15 APE12-dist-na 9.738 APE11-dist-na 12.432 APE10-dist-na 16.544 APE9-dist-out 11.684 None None None XRAY 1.71 0.191 0.225 C 295 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 8s99 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AA P29597 577 868 1187.0 ZSB:901 Type1 Pseudo DFGin 7.465 12.783 None -59.49, 156.87 -53.44, 145.49 -73.94, -3.93 28.08, 142.08 71.29, -152.49 in-na in 9.645 Saltbr-na 999.0 HRD-in -80.97, -57.69 81.03, 6.24 na-out-out SNCaoo out-out ActLoopNT-out 8.468 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.12, -39.62 APE9-dihe-out -57.45, -31.53 APE8-dihe-out -85.9, -0.44 APE8-rot-na 294.43 APE67-dihe-out -98.22, 12.4 -65.02, 133.34 APE12-dist-na 9.967 APE11-dist-na 12.285 APE10-dist-na 16.605 APE9-dist-out 11.838 None None None XRAY 1.83 0.186 0.224 A 295 264 28 0 0 0 [[589, 868], [897, 1171]] 2.0 8s9a Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AB P29597 578 867 1187.0 ZSB:901 Type1 Pseudo DFGin 7.549 12.607 None -55.02, 155.39 -55.48, 149.15 -78.11, 1.0 33.17, 138.7 68.16, -152.66 in-na in 9.568 Saltbr-na 999.0 HRD-in -83.23, -60.75 91.28, -0.48 na-out-out SNCaoo out-out ActLoopNT-out 8.591 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.5, -42.74 APE9-dihe-out -57.15, -27.18 APE8-dihe-out -83.95, -1.9 APE8-rot-na 289.14 APE67-dihe-out -98.17, 15.26 -66.86, 137.45 APE12-dist-na 9.96 APE11-dist-na 12.078 APE10-dist-na 16.412 APE9-dist-out 11.895 None None None XRAY 1.83 0.186 0.224 B 295 263 28 0 0 0 [[589, 868], [897, 1171]] 2.0 8s9a Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AC P29597 578 867 1187.0 ZSB:901 Type1 Pseudo DFGin 7.452 12.668 None -61.15, 155.8 -50.19, 148.71 -74.89, -0.44 30.12, 140.82 66.87, -150.05 in-na in 9.655 Saltbr-na 999.0 HRD-in -81.68, -62.05 88.29, 3.19 na-out-out SNCaoo out-out ActLoopNT-out 8.26 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.23, -43.49 APE9-dihe-out -60.0, -25.56 APE8-dihe-out -89.19, -0.15 APE8-rot-na 289.26 APE67-dihe-out -98.71, 15.21 -67.33, 135.82 APE12-dist-na 9.697 APE11-dist-na 12.309 APE10-dist-na 16.494 APE9-dist-out 11.766 None None None XRAY 1.83 0.186 0.224 C 295 261 30 0 0 0 [[589, 868], [897, 1171]] 2.0 8s9a Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5TKDA P29597 581 866 1187.0 7GL:901 Type1 Pseudo DFGin 7.513 12.63 None -67.32, 165.44 -61.21, 150.11 -77.85, 2.5 30.62, 144.39 70.23, -152.17 in-na in 9.487 Saltbr-na 999.0 HRD-in -86.12, -60.06 82.4, 7.11 na-out-out SNCaoo out-out ActLoopNT-out 8.163 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.41, -39.74 APE9-dihe-out -61.67, -21.18 APE8-dihe-out -86.78, -7.05 APE8-rot-na 289.65 APE67-dihe-out -93.06, 5.59 -69.25, 133.26 APE12-dist-na 9.69 APE11-dist-na 12.22 APE10-dist-na 16.406 APE9-dist-out 11.578 None None None XRAY 1.92 0.193 0.215 A 298 248 40 0 0 0 [[589, 868], [897, 1171]] 2.0 5tkd Homo sapiens TYR_TYK2-1_HUMAN TYR 4.2e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5TKDB P29597 581 867 1187.0 7GL:901 Type1 Pseudo DFGin 7.534 12.489 None -66.93, 165.19 -61.5, 149.63 -77.96, 1.32 30.48, 144.44 72.41, -154.16 in-na in 9.422 Saltbr-na 999.0 HRD-in -86.72, -59.64 79.99, 10.31 na-out-out SNCaoo out-out ActLoopNT-out 8.029 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.45, -40.77 APE9-dihe-out -60.64, -23.02 APE8-dihe-out -86.44, -3.61 APE8-rot-na 200.95 APE67-dihe-out -92.39, 6.26 -73.47, 133.63 APE12-dist-na 9.666 APE11-dist-na 12.184 APE10-dist-na 16.381 APE9-dist-out 11.457 None None None XRAY 1.92 0.193 0.215 B 298 247 41 0 0 0 [[589, 868], [897, 1171]] 2.0 5tkd Homo sapiens TYR_TYK2-1_HUMAN TYR 4.2e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 3ZONA P29597 577 870 1187.0 IK1:1871 Type1 Pseudo DFGin 7.368 12.762 None -83.03, 173.2 -63.77, 153.55 -76.54, -5.77 26.47, 146.49 67.78, -154.99 in-na in 9.655 Saltbr-na 999.0 HRD-in -77.23, -57.87 87.41, -1.46 na-out-out SNCaoo out-out ActLoopNT-out 8.36 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.01, -48.69 APE9-dihe-out -50.14, -31.16 APE8-dihe-out -81.83, -2.56 APE8-rot-na 292.76 APE67-dihe-out -91.8, 2.07 -66.27, 133.13 APE12-dist-na 10.153 APE11-dist-na 12.31 APE10-dist-na 16.62 APE9-dist-out 11.977 None None None XRAY 2.15 0.217 0.268 A 335 261 33 0 0 0 [[589, 868], [897, 1171]] 2.0 3zon Homo sapiens TYR_TYK2-1_HUMAN TYR 6.5e-60 208.7 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZRA P29597 578 867 1187.0 LAJ:901 Type1 Pseudo DFGin 7.777 12.781 None -69.45, 168.07 -65.99, 154.27 -73.6, -4.41 23.84, 151.16 77.17, -140.45 in-na in 9.435 Saltbr-na 999.0 HRD-in -82.75, -62.0 89.42, -4.52 na-out-out SNCaoo out-out ActLoopNT-out 8.095 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.36, -40.74 APE9-dihe-out -63.5, -26.3 APE8-dihe-out -83.27, -1.28 APE8-rot-na 205.99 APE67-dihe-out -86.49, -0.68 -74.39, 134.15 APE12-dist-na 9.712 APE11-dist-na 12.195 APE10-dist-na 16.359 APE9-dist-out 11.553 None None None XRAY 2.56 0.19 0.229 A 317 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzr Homo sapiens TYR_TYK2-1_HUMAN TYR 3e-60 209.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZRB P29597 580 868 1187.0 LAJ:901 Type1 Pseudo DFGin 7.794 12.735 None -69.51, 167.49 -66.18, 155.4 -74.3, -4.56 23.99, 151.21 77.6, -139.58 in-na in 9.371 Saltbr-na 999.0 HRD-in -85.74, -61.72 89.77, -6.44 na-out-out SNCaoo out-out ActLoopNT-out 8.164 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.72, -41.32 APE9-dihe-out -63.03, -22.95 APE8-dihe-out -84.92, -4.81 APE8-rot-na 227.24 APE67-dihe-out -86.54, 0.37 -71.84, 134.55 APE12-dist-na 9.706 APE11-dist-na 12.223 APE10-dist-na 16.378 APE9-dist-out 11.55 None None None XRAY 2.56 0.19 0.229 B 317 259 30 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzr Homo sapiens TYR_TYK2-1_HUMAN TYR 3e-60 209.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 4WOVA P29597 580 869 1187.0 3SM:901 Type1 Pseudo DFGin 7.414 12.612 None -81.79, 172.74 -64.96, 152.2 -79.14, 3.8 29.41, 144.45 64.39, -148.74 in-na in 9.434 Saltbr-na 999.0 HRD-in -91.37, -57.71 81.66, 1.38 na-out-out SNCaoo out-out ActLoopNT-out 8.472 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.89, -40.33 APE9-dihe-out -59.96, -25.88 APE8-dihe-out -82.28, -6.26 APE8-rot-na 203.31 APE67-dihe-out -93.77, 1.64 -65.5, 131.41 APE12-dist-na 9.865 APE11-dist-na 12.155 APE10-dist-na 16.373 APE9-dist-out 11.62 None None None XRAY 1.8 0.193 0.214 A 317 258 32 0 0 0 [[589, 868], [897, 1171]] 2.0 4wov Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 4WOVB P29597 580 867 1187.0 3SM:901 Type1 Pseudo DFGin 7.375 12.564 None -82.96, 174.29 -64.97, 150.22 -78.54, 4.38 29.82, 144.02 64.16, -150.45 in-na in 9.386 Saltbr-na 999.0 HRD-in -91.0, -57.11 81.71, 1.86 na-out-out SNCaoo out-out ActLoopNT-out 8.54 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.69, -39.07 APE9-dihe-out -62.22, -22.21 APE8-dihe-out -86.45, -3.31 APE8-rot-na 190.55 APE67-dihe-out -96.7, 6.38 -71.04, 134.12 APE12-dist-na 9.828 APE11-dist-na 12.112 APE10-dist-na 16.313 APE9-dist-out 11.656 None None None XRAY 1.8 0.193 0.214 B 317 256 33 0 0 0 [[589, 868], [897, 1171]] 2.0 4wov Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NSLA P29597 581 866 1187.0 KZJ:901 Type1 Pseudo DFGin 7.447 12.627 None -65.67, 163.1 -59.9, 147.3 -72.43, 0.95 25.4, 149.24 71.0, -150.31 in-na in 9.45 Saltbr-na 999.0 HRD-in -79.19, -61.15 86.61, -0.76 na-out-out SNCaoo out-out ActLoopNT-out 8.317 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.34, -39.28 APE9-dihe-out -63.02, -22.39 APE8-dihe-out -82.22, -10.35 APE8-rot-na 292.93 APE67-dihe-out -91.53, -2.04 -67.32, 133.05 APE12-dist-na 9.722 APE11-dist-na 12.197 APE10-dist-na 16.413 APE9-dist-out 11.7 None None None XRAY 2.15 0.203 0.213 A 317 251 37 0 0 0 [[589, 868], [897, 1171]] 2.0 6nsl Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NSLB P29597 581 867 1187.0 KZJ:901 Type1 Pseudo DFGin 7.466 12.543 None -65.53, 162.68 -58.2, 146.74 -72.38, 1.37 25.74, 148.82 71.06, -152.3 in-na in 9.423 Saltbr-na 999.0 HRD-in -80.39, -61.97 87.32, -2.61 na-out-out SNCaoo out-out ActLoopNT-out 8.241 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.57, -38.38 APE9-dihe-out -63.64, -23.52 APE8-dihe-out -84.88, -4.11 APE8-rot-na 200.51 APE67-dihe-out -91.36, -1.36 -71.83, 133.14 APE12-dist-na 9.667 APE11-dist-na 12.177 APE10-dist-na 16.391 APE9-dist-out 11.568 None None None XRAY 2.15 0.203 0.213 B 317 248 40 0 0 0 [[589, 868], [897, 1171]] 2.0 6nsl Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZEA P29597 581 863 1187.0 L8Y:901 Type1 Pseudo DFGin 7.517 12.327 None -67.15, 165.53 -62.27, 154.27 -78.2, -0.61 28.22, 144.21 70.11, -150.04 in-na in 9.308 Saltbr-na 999.0 HRD-in -90.68, -61.1 81.57, 5.39 na-out-out SNCaoo out-out ActLoopNT-out 8.127 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.25, -36.4 APE9-dihe-out -64.18, -24.4 APE8-dihe-out -85.3, -4.22 APE8-rot-na 196.84 APE67-dihe-out -93.12, 7.25 -69.65, 135.35 APE12-dist-na 9.814 APE11-dist-na 12.241 APE10-dist-na 16.458 APE9-dist-out 11.439 None None None XRAY 1.96 0.197 0.227 A 317 250 38 0 0 0 [[589, 868], [897, 1171]] 2.0 6nze Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZEB P29597 580 867 1187.0 L8Y:901 Type1 Pseudo DFGin 7.51 12.331 None -67.31, 165.25 -60.76, 154.35 -79.17, -0.55 28.55, 143.7 69.96, -145.72 in-na in 9.336 Saltbr-na 999.0 HRD-in -88.53, -60.87 81.08, 6.03 na-out-out SNCaoo out-out ActLoopNT-out 8.073 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.94, -35.62 APE9-dihe-out -64.8, -24.24 APE8-dihe-out -85.49, -3.91 APE8-rot-na 196.79 APE67-dihe-out -92.3, 6.8 -70.0, 135.83 APE12-dist-na 9.732 APE11-dist-na 12.151 APE10-dist-na 16.38 APE9-dist-out 11.416 None None None XRAY 1.96 0.197 0.227 B 317 254 35 0 0 0 [[589, 868], [897, 1171]] 2.0 6nze Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZFA P29597 580 865 1187.0 L91:901 Type1 Pseudo DFGin 7.6 12.671 None -71.29, 168.26 -64.87, 155.03 -75.86, -3.47 25.03, 153.09 77.38, -149.91 in-na in 9.401 Saltbr-na 999.0 HRD-in -80.34, -62.67 82.96, 5.24 na-out-out SNCaoo out-out ActLoopNT-out 8.094 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.48, -39.01 APE9-dihe-out -62.83, -25.44 APE8-dihe-out -82.23, -7.85 APE8-rot-na 215.68 APE67-dihe-out -92.43, 5.04 -68.27, 132.64 APE12-dist-na 9.808 APE11-dist-na 12.262 APE10-dist-na 16.517 APE9-dist-out 11.623 None None None XRAY 2.39 0.205 0.231 A 317 247 42 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzf Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZFB P29597 580 867 1187.0 L91:901 Type1 Pseudo DFGin 7.67 12.598 None -70.84, 168.4 -64.97, 153.82 -75.67, -2.7 25.33, 152.34 77.04, -149.81 in-na in 9.372 Saltbr-na 999.0 HRD-in -81.43, -61.17 83.19, 3.8 na-out-out SNCaoo out-out ActLoopNT-out 8.112 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.59, -38.89 APE9-dihe-out -62.81, -25.28 APE8-dihe-out -84.37, -2.23 APE8-rot-na 213.59 APE67-dihe-out -91.99, 5.73 -72.88, 133.85 APE12-dist-na 9.752 APE11-dist-na 12.229 APE10-dist-na 16.478 APE9-dist-out 11.555 None None None XRAY 2.39 0.205 0.231 B 317 248 41 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzf Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZHA P29597 581 866 1187.0 L9A:4000 Type1 Pseudo DFGin 7.406 12.772 None -62.74, 170.7 -72.48, 150.15 -70.83, -2.83 23.35, 152.01 73.55, -152.26 in-na in 9.497 Saltbr-na 999.0 HRD-in -83.24, -60.86 86.7, -4.43 na-out-out SNCaoo out-out ActLoopNT-out 8.387 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.05, -35.12 APE9-dihe-out -65.62, -29.8 APE8-dihe-out -77.88, -5.55 APE8-rot-na 294.99 APE67-dihe-out -89.76, 4.67 -72.08, 133.72 APE12-dist-na 9.775 APE11-dist-na 12.229 APE10-dist-na 16.47 APE9-dist-out 11.317 None None None XRAY 2.73 0.193 0.215 A 317 249 39 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzh Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZHB P29597 580 867 1187.0 L9A:4000 Type1 Pseudo DFGin 7.436 12.599 None -60.73, 169.6 -71.23, 150.14 -70.46, -1.47 23.31, 151.91 71.77, -152.11 in-na in 9.376 Saltbr-na 999.0 HRD-in -83.11, -60.28 86.79, -5.89 na-out-out SNCaoo out-out ActLoopNT-out 8.308 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.38, -35.33 APE9-dihe-out -65.44, -29.63 APE8-dihe-out -78.49, -5.17 APE8-rot-na 295.66 APE67-dihe-out -89.42, 4.66 -71.76, 134.2 APE12-dist-na 9.735 APE11-dist-na 12.216 APE10-dist-na 16.437 APE9-dist-out 11.269 None None None XRAY 2.73 0.193 0.215 B 317 249 40 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzh Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZPA P29597 580 869 1187.0 LB7:901 Type1 Pseudo DFGin 7.454 12.358 None -74.98, 168.42 -62.51, 146.95 -73.8, -0.03 29.8, 144.9 77.36, -162.45 in-na in 9.216 Saltbr-na 999.0 HRD-in -77.18, -62.62 87.16, 3.67 na-out-out SNCaoo out-out ActLoopNT-out 8.307 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -55.98, -44.81 APE9-dihe-out -54.69, -25.84 APE8-dihe-out -83.74, 2.24 APE8-rot-na 279.61 APE67-dihe-out -91.79, -3.26 -74.14, 129.81 APE12-dist-na 9.758 APE11-dist-na 11.986 APE10-dist-na 16.154 APE9-dist-out 11.555 None None None XRAY 2.35 0.191 0.238 A 317 259 31 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzp Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZPB P29597 580 868 1187.0 LB7:901 Type1 Pseudo DFGin 7.457 12.377 None -74.39, 168.01 -61.52, 147.56 -74.66, 0.45 29.5, 145.4 75.25, -161.58 in-na in 9.288 Saltbr-na 999.0 HRD-in -77.4, -62.3 87.31, 3.57 na-out-out SNCaoo out-out ActLoopNT-out 8.247 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -56.49, -45.45 APE9-dihe-out -54.3, -24.89 APE8-dihe-out -83.35, -4.08 APE8-rot-na 280.62 APE67-dihe-out -91.28, -1.02 -71.12, 130.29 APE12-dist-na 9.773 APE11-dist-na 12.02 APE10-dist-na 16.21 APE9-dist-out 11.556 None None None XRAY 2.35 0.191 0.238 B 317 260 29 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzp Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZQA P29597 580 867 1187.0 LB4:4000 Type1 Pseudo DFGin 7.504 12.4 None -72.22, 171.6 -66.25, 148.31 -74.94, 3.34 30.76, 143.31 66.4, -168.53 in-na in 9.039 Saltbr-na 999.0 HRD-in -79.47, -65.7 83.13, 11.6 na-out-out SNCaoo out-out ActLoopNT-out 8.497 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.2, -35.07 APE9-dihe-out -63.1, -22.48 APE8-dihe-out -87.78, -5.31 APE8-rot-na 268.32 APE67-dihe-out -91.66, 0.19 -69.75, 131.87 APE12-dist-na 9.881 APE11-dist-na 12.092 APE10-dist-na 16.368 APE9-dist-out 11.72 None None None XRAY 2.11 0.199 0.237 A 317 256 33 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzq Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 6NZQB P29597 580 868 1187.0 LB4:4000 Type1 Pseudo DFGin 7.552 12.37 None -70.99, 170.41 -64.59, 148.83 -75.35, 4.18 30.96, 143.54 65.3, -166.93 in-na in 8.958 Saltbr-na 999.0 HRD-in -80.49, -65.88 83.34, 10.69 na-out-out SNCaoo out-out ActLoopNT-out 8.442 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.78, -35.63 APE9-dihe-out -62.43, -22.89 APE8-dihe-out -87.56, -5.29 APE8-rot-na 268.51 APE67-dihe-out -92.56, 0.73 -69.67, 131.53 APE12-dist-na 9.911 APE11-dist-na 12.088 APE10-dist-na 16.439 APE9-dist-out 11.694 None None None XRAY 2.11 0.199 0.237 B 317 258 31 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzq Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7OA P29597 580 867 1187.0 VZJ:901 Type1 Pseudo DFGin 7.366 12.565 None -66.43, 170.03 -67.36, 143.81 -70.91, 1.79 25.53, 145.85 78.47, -152.75 in-na in 9.266 Saltbr-na 999.0 HRD-in -75.49, -66.33 85.17, 12.8 na-out-out SNCaoo out-out ActLoopNT-out 8.181 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -57.32, -40.35 APE9-dihe-out -58.15, -35.87 APE8-dihe-out -71.09, -6.29 APE8-rot-na 289.01 APE67-dihe-out -84.78, -2.19 -73.46, 133.77 APE12-dist-na 9.765 APE11-dist-na 12.088 APE10-dist-na 16.266 APE9-dist-out 11.763 None None None XRAY 2.82 0.181 0.252 A 317 257 32 0 0 0 [[589, 868], [897, 1171]] 2.0 7k7o Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7OB P29597 580 868 1187.0 VZJ:901 Type1 Pseudo DFGin 7.723 12.247 None -71.51, -175.68 -81.24, 151.01 -79.84, 4.8 35.04, 138.85 72.06, -152.96 in-na in 9.264 Saltbr-na 999.0 HRD-in -101.81, -60.3 88.52, -5.44 na-out-out SNCaoo out-out ActLoopNT-out 8.923 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.95, -43.16 APE9-dihe-out -55.55, -22.53 APE8-dihe-out -85.45, 0.22 APE8-rot-na 226.83 APE67-dihe-out -83.49, -4.03 -76.46, 136.55 APE12-dist-na 9.628 APE11-dist-na 12.199 APE10-dist-na 16.268 APE9-dist-out 11.283 None None None XRAY 2.82 0.181 0.252 B 317 257 32 0 0 0 [[589, 868], [897, 1171]] 2.0 7k7o Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7QA P29597 580 867 1187.0 VZG:901 Type1 Pseudo DFGin 7.543 12.533 None -69.2, 167.5 -63.98, 154.51 -77.3, 7.34 29.56, 146.11 63.89, -146.65 in-na in 9.281 Saltbr-na 999.0 HRD-in -79.96, -60.41 88.18, -6.56 na-out-out SNCaoo out-out ActLoopNT-out 8.398 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.8, -37.69 APE9-dihe-out -61.19, -23.02 APE8-dihe-out -86.96, -5.2 APE8-rot-na 283.59 APE67-dihe-out -89.93, 5.32 -68.44, 135.46 APE12-dist-na 9.824 APE11-dist-na 12.119 APE10-dist-na 16.488 APE9-dist-out 11.802 None None None XRAY 2.27 0.191 0.215 A 317 256 33 0 0 0 [[589, 868], [897, 1171]] 2.0 7k7q Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 7K7QB P29597 580 868 1187.0 VZG:901 Type1 Pseudo DFGin 7.528 12.484 None -69.63, 166.47 -62.41, 154.32 -76.74, 6.87 29.05, 146.64 63.93, -146.22 in-na in 9.264 Saltbr-na 999.0 HRD-in -80.84, -60.47 88.54, -6.14 na-out-out SNCaoo out-out ActLoopNT-out 8.387 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.52, -36.89 APE9-dihe-out -61.37, -23.14 APE8-dihe-out -89.62, -0.64 APE8-rot-na 285.2 APE67-dihe-out -89.84, 4.92 -69.09, 135.18 APE12-dist-na 9.785 APE11-dist-na 12.127 APE10-dist-na 16.459 APE9-dist-out 11.701 None None None XRAY 2.27 0.191 0.215 B 317 251 38 0 0 0 [[589, 868], [897, 1171]] 2.0 7k7q Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB5A P29597 580 868 1187.0 ZOQ:902 Type1 Pseudo DFGin 7.575 12.828 None -72.9, 166.16 -62.82, 156.7 -75.2, -1.8 19.44, 155.05 65.85, -157.21 in-na in 9.628 Saltbr-na 999.0 HRD-in -77.18, -55.68 90.86, -17.89 na-out-out SNCaoo out-out ActLoopNT-out 8.033 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.91, -37.05 APE9-dihe-out -64.82, -24.45 APE8-dihe-out -87.22, -2.73 APE8-rot-na 294.55 APE67-dihe-out -99.67, 13.88 -62.74, 133.89 APE12-dist-na 9.966 APE11-dist-na 12.452 APE10-dist-na 16.637 APE9-dist-out 11.819 None None None XRAY 2.32 0.187 0.243 A 326 257 32 0 0 0 [[589, 868], [897, 1171]] 2.0 8tb5 Homo sapiens TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB5B P29597 580 868 1187.0 ZOQ:902 Type1 Pseudo DFGin 7.354 12.83 None -69.46, 162.15 -62.48, 155.25 -75.42, -2.04 28.22, 143.07 66.45, -159.8 in-na in 9.655 Saltbr-na 999.0 HRD-in -80.42, -58.38 87.54, 2.75 na-out-out SNCaoo out-out ActLoopNT-out 8.229 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.71, -36.16 APE9-dihe-out -65.57, -18.78 APE8-dihe-out -89.43, 3.6 APE8-rot-na 301.67 APE67-dihe-out -95.11, 8.54 -67.3, 136.04 APE12-dist-na 10.02 APE11-dist-na 12.281 APE10-dist-na 16.5 APE9-dist-out 11.726 None None None XRAY 2.32 0.187 0.243 B 326 257 32 0 0 0 [[589, 868], [897, 1171]] 2.0 8tb5 Homo sapiens TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB6A P29597 572 869 1187.0 ZOI:901 Type1 Pseudo DFGin 7.519 12.918 None -70.48, 163.05 -64.31, 156.7 -77.96, 2.63 25.15, 152.72 70.88, -150.51 in-na in 9.757 Saltbr-na 999.0 HRD-in -88.04, -58.25 80.3, 7.16 na-out-out SNCaoo out-out ActLoopNT-out 8.005 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.83, -38.13 APE9-dihe-out -58.13, -23.83 APE8-dihe-out -87.03, -4.8 APE8-rot-na 225.26 APE67-dihe-out -95.58, 10.52 -67.22, 136.28 APE12-dist-na 9.67 APE11-dist-na 12.214 APE10-dist-na 16.343 APE9-dist-out 11.339 None None None XRAY 1.96 0.195 0.236 A 326 263 33 0 0 0 [[589, 868], [897, 1171]] 2.0 8tb6 Homo sapiens TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8TB6B P29597 580 867 1187.0 ZOI:901 Type1 Pseudo DFGin 7.575 12.834 None -75.19, 161.88 -63.62, 154.56 -77.31, 0.0 28.4, 144.85 69.85, -142.97 in-na in 9.746 Saltbr-na 999.0 HRD-in -86.92, -60.13 92.81, -6.33 na-out-out SNCaoo out-out ActLoopNT-out 8.229 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.54, -39.0 APE9-dihe-out -57.31, -25.9 APE8-dihe-out -87.7, -3.61 APE8-rot-na 309.71 APE67-dihe-out -99.75, 10.76 -63.68, 135.57 APE12-dist-na 9.794 APE11-dist-na 12.116 APE10-dist-na 16.334 APE9-dist-out 11.431 None None None XRAY 1.96 0.195 0.236 B 326 254 35 0 0 0 [[589, 868], [897, 1171]] 2.0 8tb6 Homo sapiens TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5C01A P29597 580 868 1187.0 UNL:901 Type1 Pseudo DFGin 7.494 12.953 None -78.77, 168.17 -59.3, 158.84 -78.02, -0.56 29.95, 141.01 70.43, -143.96 in-na in 9.86 Saltbr-na 999.0 HRD-in -88.89, -66.71 89.22, 5.88 na-out-out SNCaoo out-out ActLoopNT-out 8.02 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.06, -43.56 APE9-dihe-out -60.5, -24.62 APE8-dihe-out -84.02, 0.04 APE8-rot-na 309.1 APE67-dihe-out -102.6, 18.85 -65.89, 133.72 APE12-dist-na 10.035 APE11-dist-na 12.558 APE10-dist-na 16.715 APE9-dist-out 11.348 None None None XRAY 2.15 0.197 0.24 A 342 258 31 0 0 0 [[589, 868], [897, 1171]] 2.0 5c01 Homo sapiens TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5C01B P29597 579 869 1187.0 UNL:901 Type1 Pseudo DFGin 7.503 12.99 None -83.69, 167.93 -60.38, 156.97 -77.3, 1.6 26.16, 146.38 64.95, -141.34 in-na in 9.846 Saltbr-na 999.0 HRD-in -91.02, -62.48 85.42, 13.36 na-out-out SNCaoo out-out ActLoopNT-out 8.054 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.57, -43.79 APE9-dihe-out -56.12, -28.45 APE8-dihe-out -84.03, 3.14 APE8-rot-na 209.42 APE67-dihe-out -101.1, 17.13 -74.09, 134.94 APE12-dist-na 9.989 APE11-dist-na 12.592 APE10-dist-na 16.738 APE9-dist-out 11.636 None None None XRAY 2.15 0.197 0.24 B 342 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 5c01 Homo sapiens TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
OTHER NFR5-12 Q70KR1_LOTJA 8S79A Q70KR1 280 563 595.0 No_ligand No_ligand Pseudo DFGin 6.7 13.868 BLAminus -141.84, -177.07 52.5, 69.51 -82.54, 22.49 287.3, 79.08 -67.38, -26.68 in-out in 7.718 Saltbr-out 3.649 HRD-in -72.18, -35.12 62.7, 3.73 out-in-none SNCoin in-none ActLoopNT-in 2.851 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.29 0.198 0.231 A 288 284 0 0 0 0 [[319, 463], [457, 560]] 2.0 8s79 Lotus japonicus OTHER_NFR5-12_LOTJA TKL 1.6e-32 157.3 14 150 224 450 451 452 454 456 339 349 353 430 432 431 433 467 0 0 0 0 0 0 0 0 380 Nod-factor receptor 5
OTHER NFR5-12 Q70KR1_LOTJA 8S79B Q70KR1 300 563 595.0 No_ligand No_ligand Pseudo DFGin 6.965 14.233 BLAminus -136.72, 179.37 59.59, 65.64 -81.75, 26.01 290.82, 82.64 -71.44, -48.87 in-out in 9.102 Saltbr-out 6.228 HRD-in -68.14, -46.66 71.86, 0.88 out-in-none SNCoin in-none ActLoopNT-in 2.83 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.29 0.198 0.231 B 288 260 4 0 0 0 [[319, 463], [457, 560]] 2.0 8s79 Lotus japonicus OTHER_NFR5-12_LOTJA TKL 1.6e-32 157.3 14 150 224 450 451 452 454 456 339 349 353 430 432 431 433 467 0 0 0 0 0 0 0 0 380 Nod-factor receptor 5
TKL LYR4 G7K7K0_MEDTR 8PS7B G7K7K0 340 636 660.0 ANP:703 ATPlike Pseudo DFGin 7.768 15.066 BLBminus -155.57, -174.44 55.36, 56.3 -70.81, 152.24 289.97, 66.8 93.85, 156.74 out-out out 15.961 Saltbr-out 14.036 HRD-in -57.6, -55.05 79.6, -10.79 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -72.46, -42.72 APE9-dihe-na -56.2, -52.66 APE8-dihe-out -56.27, -29.69 APE8-rot-out 59.05 APE67-dihe-in -100.31, -14.89 -66.25, -40.12 APE12-dist-in 9.702 APE11-dist-in 13.647 APE10-dist-out 15.243 APE9-dist-out 9.612 None None None XRAY 2.1 0.225 0.269 B 297 274 23 0 0 12 [[360, 633]] 1.0 8ps7 Medicago truncatula TKL_LYR4_MEDTR TKL 4.9e-53 186.3 13 266 254 493 494 495 497 499 379 388 392 473 475 474 476 538 526 521 520 519 518 517 516 515 418 LysM-domain receptor-like kinase
TKL LYR4 G7K7K0_MEDTR 8PS7A G7K7K0 340 636 660.0 ANP:704 ATPlike Pseudo DFGin 7.344 12.491 None -132.7, -71.23 -80.99, 65.77 -101.31, -4.53 43.9, 75.68 -166.17, 141.69 out-out out 12.664 Saltbr-out 13.161 HRD-in -67.54, -63.16 83.85, -10.66 out-out-out SNCooo out-out ActLoopNT-out 9.632 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -64.12, -49.62 APE9-dihe-na -62.67, -34.57 APE8-dihe-out -58.19, -50.78 APE8-rot-in 276.77 APE67-dihe-in -82.12, -28.85 -67.98, -32.83 APE12-dist-out 14.247 APE11-dist-out 19.231 APE10-dist-out 20.4 APE9-dist-out 9.296 None None None XRAY 2.1 0.225 0.269 A 297 279 18 0 0 0 [[360, 633]] 1.0 8ps7 Medicago truncatula TKL_LYR4_MEDTR TKL 4.9e-53 186.3 13 266 254 493 494 495 497 499 379 388 392 473 475 474 476 538 526 521 520 519 518 517 516 515 418 LysM-domain receptor-like kinase
OTHER MLKL MLKL_MOUSE 4M68A Q9D2Y4 182 466 472.0 No_ligand No_ligand Pseudo DFGin 9.852 16.7 BLAplus -129.7, -163.13 77.79, 17.7 -134.64, -18.09 73.34, 102.06 -94.56, 159.05 out-out out 16.505 Saltbr-out 13.3 HRD-na-E -69.29, -48.17 86.0, -11.45 out-out-out SNCooo out-out ActLoopNT-out 11.888 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 128.37 APE9-dihe-na -54.91, -21.63 APE8-dihe-out -63.15, -25.67 APE8-rot-out 40.6 APE67-dihe-in -52.68, -39.76 -124.73, 3.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 25.824 APE9-dist-out 12.948 None None None XRAY 1.696 0.195 0.216 A 283 268 9 0 0 9 [[189, 451]] 1.0 4m68 Mus musculus OTHER_MLKL_MOUSE TKL 2.1e-48 171.1 7 266 260 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_MOUSE 4BTFA Q9D2Y4 2 463 472.0 No_ligand No_ligand Pseudo DFGin 9.681 16.7 BLAplus -133.91, -159.82 79.78, 12.69 -135.05, -21.42 69.63, 92.26 -89.6, 153.33 out-out out 16.15 Saltbr-out 11.221 HRD-na-E -72.28, -47.25 76.21, -2.88 out-out-out SNCooo out-out ActLoopNT-out 12.025 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 154.4 APE8-dihe-out -103.41, -28.46 APE8-rot-in 243.61 APE67-dihe-in -72.27, -11.5 -56.76, -28.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.4 None None None XRAY 2.604 0.209 0.256 A 469 413 8 0 0 8 [[189, 451]] 1.0 4btf Mus musculus OTHER_MLKL_MOUSE TKL 1e-47 169.7 6 266 261 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_MOUSE 4M69B Q9D2Y4 182 466 472.0 No_ligand No_ligand Pseudo None 14.113 18.823 None -93.73, 159.62 -63.02, 163.0 -50.35, -54.58 169.88, 78.24 -71.37, -37.09 out-out out 13.469 Saltbr-out 9.651 HRD-na-E -74.43, -45.05 83.78, -5.4 out-out-out SNCooo out-out ActLoopNT-out 12.232 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 7.21 APE9-dihe-na -94.48, 162.52 APE8-dihe-out -72.69, -20.09 APE8-rot-in 348.33 APE67-dihe-in -64.41, -24.19 -65.78, -12.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.954 APE9-dist-out 14.179 None None None XRAY 2.497 0.222 0.246 B 283 264 13 0 0 13 [[189, 451]] 1.0 4m69 Mus musculus OTHER_MLKL_MOUSE TKL 2.1e-48 171.1 7 266 260 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein
OTHER POMK SG196_MOUSE 5GZ9A Q3TUA9 54 337 349.0 ANP:1001,MAN:1004 ATPlike,Allosteric Pseudo DFGin 5.293 13.023 ABAminus -119.99, -54.35 -93.01, 108.48 -116.58, 23.4 308.09, 4.31 -55.72, -49.95 none-na none 999.0 Saltbr-na 999.0 HRD-out -81.79, 73.24 -60.09, -38.65 na-in-out SNCaio in-out ActLoopNT-in 3.248 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iioo APE10-dihe-na -60.33, 128.48 APE9-dihe-na -97.57, 144.89 APE8-dihe-in -131.17, 161.49 APE8-rot-na 301.17 APE67-dihe-out -101.62, -18.24 97.94, -172.65 APE12-dist-in 12.549 APE11-dist-in 13.729 APE10-dist-out 17.531 APE9-dist-out 9.743 N66Q,N164Q None None XRAY 2.4 0.234 0.268 A 305 280 4 0 0 2 [[73, 337]] 1.0 5gz9 Mus musculus OTHER_POMK_MOUSE POMK 1.2e-147 496.2 1 265 265 225 226 227 229 231 107 121 125 200 202 201 203 280 256 251 250 249 248 247 246 245 149 Protein O-mannose kinase
OTHER POMK SG196_MOUSE 5GZ8A Q3TUA9 54 337 349.0 No_ligand No_ligand Pseudo DFGin 4.936 13.224 ABAminus -117.42, -46.49 -93.1, 109.24 -114.97, 25.11 303.9, 6.2 -83.07, -8.89 none-na none 999.0 Saltbr-na 999.0 HRD-out -78.55, 82.62 -71.19, -27.89 na-in-out SNCaio in-out ActLoopNT-in 3.28 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iooo APE10-dihe-na -71.9, 132.75 APE9-dihe-na -101.64, 147.44 APE8-dihe-in -135.98, 164.92 APE8-rot-na 301.94 APE67-dihe-out -112.69, -14.59 101.92, -170.48 APE12-dist-in 13.032 APE11-dist-out 14.216 APE10-dist-out 18.039 APE9-dist-out 9.704 N66Q,N164Q None None XRAY 2.5 0.274 0.293 A 305 272 12 0 0 4 [[73, 337]] 1.0 5gz8 Mus musculus OTHER_POMK_MOUSE POMK 1.2e-147 496.2 1 265 265 225 226 227 229 231 107 121 125 200 202 201 203 280 256 251 250 249 248 247 246 245 149 Protein O-mannose kinase
OTHER PAN3 PAN3_NEUCR 4BWKA Q7SDP4 235 646 656.0 AGS:1647 ATPlike Pseudo DFGin 8.495 13.09 None -115.86, 18.21 -139.38, 20.36 -67.09, 152.08 286.46, 999.0 74.54, -4.0 out-na out 14.22 Saltbr-na 999.0 HRD-in -64.9, -42.26 69.75, -63.5 na-out-na SNCaoa out-na ActLoopNT-out 6.898 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -56.05, -33.42 APE9-dihe-na -88.79, -48.0 APE8-dihe-na -71.22, -9.91 APE8-rot-na 304.05 APE67-dihe-na -61.19, -29.14 -123.36, 9.46 APE12-dist-na 1.535 APE11-dist-na 4.895 APE10-dist-na 5.205 APE9-dist-na 11.464 None None None XRAY 3.3 0.254 0.294 A 429 392 10 0 0 0 [[258, 516]] 1.0 4bwk Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4 264 261 424 425 426 428 430 302 318 322 405 407 406 408 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4BWKB Q7SDP4 235 646 656.0 AGS:1647 ATPlike Pseudo DFGin 8.098 12.897 None -116.7, 18.5 -139.0, 22.15 -67.02, 151.82 287.13, 999.0 73.49, -6.49 out-na out 13.863 Saltbr-na 999.0 HRD-in -66.71, -43.56 68.66, -62.54 na-out-na SNCaoa out-na ActLoopNT-out 6.901 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -57.01, -33.89 APE9-dihe-na -87.36, -45.86 APE8-dihe-na -67.7, -8.98 APE8-rot-na 303.47 APE67-dihe-na -166.92, 999.0 -122.6, 109.05 APE12-dist-na 1.57 APE11-dist-na 4.926 APE10-dist-na 5.367 APE9-dist-na 12.432 None None None XRAY 3.3 0.254 0.294 B 429 387 14 0 0 5 [[258, 516]] 1.0 4bwk Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4 264 261 424 425 426 428 430 302 318 322 405 407 406 408 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4CZYB Q7SDP4 234 645 656.0 ANP:61650 ATPlike Pseudo DFGin 8.636 12.999 None -108.01, 7.82 -124.9, 18.28 -71.16, 143.54 291.41, 999.0 81.95, -4.35 out-na out 13.97 Saltbr-na 999.0 HRD-in -64.78, -43.28 69.3, -58.59 na-out-na SNCaoa out-na ActLoopNT-out 7.042 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -68.73, -37.24 APE9-dihe-na -75.95, -42.57 APE8-dihe-na -71.33, -35.43 APE8-rot-na 302.88 APE67-dihe-na -61.0, -48.02 -101.37, 21.03 APE12-dist-na 1.544 APE11-dist-na 4.84 APE10-dist-na 5.824 APE9-dist-na 11.769 None None None XRAY 3.4 0.223 0.263 B 429 403 6 0 0 0 [[258, 516]] 1.0 4czy Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4 264 261 424 425 426 428 430 302 318 322 405 407 406 408 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4CZYD Q7SDP4 234 645 656.0 ANP:61650 ATPlike Pseudo DFGin 8.389 12.627 None -108.63, 8.9 -122.37, 20.29 -71.82, 141.42 292.67, 999.0 81.18, -5.38 out-na out 13.908 Saltbr-na 999.0 HRD-in -65.6, -43.11 68.0, -59.39 na-out-na SNCaoa out-na ActLoopNT-out 6.96 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -69.97, -39.27 APE9-dihe-na -74.97, -41.75 APE8-dihe-na -69.88, -35.71 APE8-rot-na 304.18 APE67-dihe-na -59.83, -48.03 -102.6, 21.19 APE12-dist-na 1.535 APE11-dist-na 4.833 APE10-dist-na 5.688 APE9-dist-na 12.012 None None None XRAY 3.4 0.223 0.263 D 429 403 6 0 0 0 [[258, 516]] 1.0 4czy Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4 264 261 424 425 426 428 430 302 318 322 405 407 406 408 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4BWXA Q7SDP4 234 646 656.0 AGS:1647 ATPlike Pseudo DFGin 7.942 12.815 None -114.92, 18.69 -139.36, 20.25 -66.2, 154.39 287.13, 999.0 71.2, -3.87 out-na out 14.696 Saltbr-na 999.0 HRD-in -65.26, -41.46 68.71, -60.85 na-out-na SNCaoa out-na ActLoopNT-out 6.852 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -57.52, -32.86 APE9-dihe-na -89.29, -47.03 APE8-dihe-na -70.13, -10.67 APE8-rot-na 304.73 APE67-dihe-na -61.75, -33.62 -123.15, 12.73 APE12-dist-na 1.538 APE11-dist-na 4.866 APE10-dist-na 5.325 APE9-dist-na 11.917 L510M,G511P,G512M,T514G,T515A,H516R,L517F None None XRAY 2.85 0.213 0.242 A 429 395 10 0 0 0 [[258, 516]] 1.0 4bwx Neurospora crassa OTHER_PAN3_NEUCR PAN3 1.1e-59 210.5 4 282 279 424 425 426 428 430 302 318 322 405 407 406 408 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4BWXB Q7SDP4 234 646 656.0 AGS:1647 ATPlike Pseudo DFGin 8.062 12.942 None -115.89, 18.73 -138.78, 21.11 -66.02, 153.84 287.45, 999.0 70.44, -4.24 out-na out 13.517 Saltbr-na 999.0 HRD-in -64.84, -41.41 68.02, -61.18 na-out-na SNCaoa out-na ActLoopNT-out 6.89 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -59.2, -32.89 APE9-dihe-na -88.22, -46.65 APE8-dihe-na -69.2, -11.95 APE8-rot-na 305.01 APE67-dihe-na -59.96, -34.44 -124.18, 13.25 APE12-dist-na 1.54 APE11-dist-na 4.865 APE10-dist-na 5.361 APE9-dist-na 12.007 L510M,G511P,G512M,T514G,T515A,H516R,L517F None None XRAY 2.85 0.213 0.242 B 429 397 6 0 0 0 [[258, 516]] 1.0 4bwx Neurospora crassa OTHER_PAN3_NEUCR PAN3 1.1e-59 210.5 4 282 279 424 425 426 428 430 302 318 322 405 407 406 408 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
CAMK None A0A3P9GXN4_ORYLA 9QJ2A A0A3P9GXN4 421 763 930.0 No_ligand No_ligand Pseudo DFGin 5.816 14.574 ABAminus -103.19, 10.84 -129.61, 124.02 -134.01, 15.15 279.12, 167.03 -69.28, -18.9 out-out out 10.596 Saltbr-out 4.888 HRD-in -107.62, -60.3 74.68, 7.37 out-in-out SNCoio in-out ActLoopNT-in 3.039 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -147.71, 158.55 APE9-dihe-na -127.68, -75.19 APE8-dihe-in -66.9, 117.12 APE8-rot-in 315.05 APE67-dihe-in -69.37, -21.14 -62.17, -40.52 APE12-dist-in 7.773 APE11-dist-out 7.485 APE10-dist-out 10.656 APE9-dist-out 8.602 None None None XRAY 2.1 0.191 0.227 A 354 343 0 0 0 0 [[450, 704]] 1.0 9qj2 Oryzias latipes CAMK_None_ORYLA CAMK 5.2e-70 241.8 1 256 256 589 590 591 593 595 479 494 498 567 569 568 570 628 616 611 610 609 608 607 606 605 524 Uncharacterized protein
CAMK None A0A3P9GXN4_ORYLA 9QJ2B A0A3P9GXN4 419 763 930.0 No_ligand No_ligand Pseudo DFGin 5.826 14.191 ABAminus -102.09, 8.39 -127.24, 124.79 -133.74, 14.79 279.29, 166.62 -68.97, -21.46 out-out out 10.488 Saltbr-out 4.606 HRD-in -108.31, -59.51 75.34, 10.01 out-in-out SNCoio in-out ActLoopNT-in 3.165 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -146.66, 158.08 APE9-dihe-na -128.06, -75.51 APE8-dihe-in -67.56, 120.62 APE8-rot-in 314.05 APE67-dihe-in -68.38, -18.1 -64.58, -41.57 APE12-dist-in 7.765 APE11-dist-out 7.453 APE10-dist-out 10.829 APE9-dist-out 8.759 None None None XRAY 2.1 0.191 0.227 B 354 345 0 0 0 0 [[450, 704]] 1.0 9qj2 Oryzias latipes CAMK_None_ORYLA CAMK 5.2e-70 241.8 1 256 256 589 590 591 593 595 479 494 498 567 569 568 570 628 616 611 610 609 608 607 606 605 524 Uncharacterized protein
CAMK CASK CSKP_RAT 6LNMA Q62915 6 335 909.0 No_ligand No_ligand Pseudo DFGin 7.679 16.419 BLAminus -125.57, -156.96 71.26, 41.84 -92.26, 21.6 283.61, 82.87 -59.28, -29.43 in-out in 9.775 Saltbr-out 5.421 HRD-in -72.06, -54.7 78.39, -5.65 out-in-in SNCoii in-in ActLoopNT-in 3.014 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.57, 142.02 APE9-dihe-na 103.56, -158.39 APE8-dihe-in -102.42, 124.74 APE8-rot-in 312.47 APE67-dihe-in -61.02, -25.98 -48.73, -46.84 APE12-dist-in 12.437 APE11-dist-in 12.077 APE10-dist-in 6.491 APE9-dist-in 3.887 None None None XRAY 2.4 0.173 0.213 A 351 325 0 0 0 0 [[12, 276]] 1.0 6lnm Rattus norvegicus CAMK_CASK_RAT CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_RAT 6LNMC Q62915 6 335 909.0 No_ligand No_ligand Pseudo DFGin 7.53 16.324 BLAminus -124.57, -155.35 70.57, 43.32 -90.1, 19.87 282.0, 84.55 -58.3, -30.97 in-out in 9.937 Saltbr-out 5.422 HRD-in -71.6, -55.71 80.52, -6.16 out-in-in SNCoii in-in ActLoopNT-in 3.007 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.18, 143.52 APE9-dihe-na 102.38, -158.49 APE8-dihe-in -102.65, 124.64 APE8-rot-in 312.81 APE67-dihe-in -60.4, -25.09 -44.75, -48.44 APE12-dist-in 12.914 APE11-dist-in 12.085 APE10-dist-in 6.512 APE9-dist-in 3.822 None None None XRAY 2.4 0.173 0.213 C 351 322 0 0 0 0 [[12, 276]] 1.0 6lnm Rattus norvegicus CAMK_CASK_RAT CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_RAT 6LNME Q62915 6 335 909.0 No_ligand No_ligand Pseudo DFGin 7.62 16.36 BLAminus -125.56, -155.57 64.88, 45.15 -89.82, 22.17 282.43, 83.22 -56.78, -33.33 in-out in 9.972 Saltbr-out 4.21 HRD-in -66.87, -57.99 76.64, -4.28 out-in-in SNCoii in-in ActLoopNT-in 3.013 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.45, 141.41 APE9-dihe-na 101.35, -152.19 APE8-dihe-in -106.58, 124.03 APE8-rot-in 310.93 APE67-dihe-in -62.75, -26.9 -46.07, -47.51 APE12-dist-in 12.775 APE11-dist-in 12.256 APE10-dist-in 6.605 APE9-dist-in 3.885 None None None XRAY 2.4 0.173 0.213 E 351 322 0 0 0 0 [[12, 276]] 1.0 6lnm Rattus norvegicus CAMK_CASK_RAT CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
OTHER MLKL D3ZKP6_RAT 6VBZA D3ZKP6 183 454 462.0 No_ligand No_ligand Pseudo DFGin 5.806 14.618 BLBminus -127.94, -150.16 82.3, 7.23 -50.29, 129.54 298.11, 127.33 -134.6, 159.72 in-in in 8.01 Saltbr-in 2.839 HRD-na-E -66.14, -44.04 96.84, -17.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -117.57, 160.85 APE9-dihe-na -74.63, 135.58 APE8-dihe-out -62.94, -16.08 APE8-rot-out 71.09 APE67-dihe-in -56.49, -25.33 -62.02, -19.84 APE12-dist-none 999.0 APE11-dist-out 22.777 APE10-dist-out 23.132 APE9-dist-out 14.696 None None None XRAY 2.192 0.184 0.215 A 295 256 16 0 0 16 [[190, 454]] 1.0 6vbz Rattus norvegicus OTHER_MLKL_RAT TKL 1.7e-47 168.1 6 265 260 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein
OTHER MLKL D3ZKP6_RAT 6VBZB D3ZKP6 182 454 462.0 No_ligand No_ligand Pseudo DFGin 6.646 15.8 BLBminus -133.61, 172.11 77.91, 57.02 -87.12, 172.28 304.15, 97.39 -154.58, -167.67 in-in in 7.826 Saltbr-in 2.43 HRD-na-E -68.53, -47.34 101.45, -26.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -138.28, 162.06 APE9-dihe-na -77.74, 131.79 APE8-dihe-out -67.86, -11.53 APE8-rot-out 53.7 APE67-dihe-in -52.65, -30.9 -54.76, -23.09 APE12-dist-none 999.0 APE11-dist-out 27.324 APE10-dist-out 24.958 APE9-dist-out 14.833 None None None XRAY 2.192 0.184 0.215 B 295 256 17 0 0 17 [[190, 454]] 1.0 6vbz Rattus norvegicus OTHER_MLKL_RAT TKL 1.7e-47 168.1 6 265 260 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein
OTHER PRAG1 PRAG1_RAT 6EWXB D3ZMK9 909 1368 1368.0 No_ligand No_ligand Pseudo DFGin 7.219 15.175 BLAminus -133.85, 172.85 70.26, 80.02 -96.45, 35.56 285.38, 96.62 -69.81, -17.12 none-na none 999.0 Saltbr-na 999.0 HRD-in -61.27, -46.37 70.02, 1.75 na-in-out SNCaio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -86.46 APE8-dihe-out 67.61, -127.28 APE8-rot-out 54.05 APE67-dihe-out -107.54, 29.89 -153.58, 137.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 25.306 None None None XRAY 2.771 0.191 0.246 B 484 358 93 0 0 8 [[957, 1297]] 1.0 6ewx Rattus norvegicus OTHER_PRAG1_RAT PEAK 3.5e-151 510.3 1 349 349 1177 1178 1179 1181 1183 997 1007 1011 1116 1118 1117 1119 1215 1204 1199 1198 1197 1196 1195 1194 1193 1067 Inactive tyrosine-protein kinase PRAG1
OTHER PRAG1 PRAG1_RAT 6EWXA D3ZMK9 914 1368 1368.0 No_ligand No_ligand Pseudo None 999.0 14.99 None -138.76, -179.41 62.27, 87.01 -105.89, 29.57 278.96, 90.95 -82.99, -12.61 none-na none 999.0 Saltbr-na 999.0 HRD-in -72.84, -50.42 66.83, 6.91 na-in-none SNCain in-none ActLoopNT-in 3.018 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -124.03, 42.88 999.0, -158.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.771 0.191 0.246 A 484 359 92 0 0 12 [[957, 1297]] 1.0 6ewx Rattus norvegicus OTHER_PRAG1_RAT PEAK 3.5e-151 510.3 1 349 349 1177 1178 1179 1181 1183 997 1007 1011 1116 1118 1117 1119 1215 1204 1199 1198 1197 1196 1195 1194 1193 1067 Inactive tyrosine-protein kinase PRAG1
OTHER CEX1 CEX1_YEAST 3VWAA Q12453 9 544 761.0 No_ligand No_ligand Pseudo DFGin 5.146 12.461 BLAminus -124.7, 158.77 103.54, 84.22 -111.14, 14.82 251.12, 18.37 -50.07, -41.29 in-na in 8.559 Saltbr-na 999.0 HRD-na-- -102.7, -59.87 84.78, -15.06 na-in-none SNCain in-none ActLoopNT-in 2.737 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE193,MSE203,MSE218,MSE266,MSE287,MSE304,MSE317 XRAY 2.2 0.17 0.207 A 560 527 0 0 0 0 [[10, 237]] 1.0 3vwa Saccharomyces cerevisiae OTHER_CEX1_YEAST SCYL 2.5e-12 53.2 6 155 150 151 152 153 155 157 47 62 66 131 133 132 134 0 0 0 0 0 0 0 0 0 93 Cytoplasmic export protein 1
OTHER CEX1 CEX1_YEAST 3VWAB Q12453 9 543 761.0 No_ligand No_ligand Pseudo DFGin 5.005 12.33 BLAminus -123.03, 148.89 124.48, 69.4 -97.56, 25.97 262.87, 13.7 -69.48, -27.98 in-na in 8.454 Saltbr-na 999.0 HRD-na-- -90.47, -61.74 86.81, -14.68 na-in-none SNCain in-none ActLoopNT-in 2.846 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE193,MSE203,MSE218,MSE266,MSE287,MSE304,MSE317 XRAY 2.2 0.17 0.207 B 560 525 0 0 0 0 [[10, 237]] 1.0 3vwa Saccharomyces cerevisiae OTHER_CEX1_YEAST SCYL 2.5e-12 53.2 6 155 150 151 152 153 155 157 47 62 66 131 133 132 134 0 0 0 0 0 0 0 0 0 93 Cytoplasmic export protein 1
OTHER PAN3-12 PAN3_YEAST 4XR7C P36102 227 679 679.0 No_ligand No_ligand Pseudo DFGin 7.563 14.177 ABAminus -101.78, -60.65 -111.32, 143.47 -96.6, 11.04 309.33, 999.0 52.49, 47.95 out-na out 14.562 Saltbr-na 999.0 HRD-out -78.84, -25.1 -93.97, -5.24 na-out-na SNCaoa out-na ActLoopNT-out 8.599 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-na 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 999.0, 999.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 3.796 0.286 0.299 C 465 440 13 0 0 12 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7B P36102 226 679 679.0 No_ligand No_ligand Pseudo DFGin 8.502 15.422 None -104.85, -81.9 -55.51, -45.21 62.67, 17.87 199.85, 999.0 45.47, 46.6 out-na out 13.49 Saltbr-na 999.0 HRD-out -76.12, -16.46 -97.99, 85.58 na-out-na SNCaoa out-na ActLoopNT-out 8.945 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -142.19, 130.31 APE9-dihe-na -74.85, 162.0 APE8-dihe-na -74.39, -32.88 APE8-rot-na 188.94 APE67-dihe-na -124.14, 114.63 -58.03, 146.49 APE12-dist-na 11.287 APE11-dist-na 13.88 APE10-dist-na 13.545 APE9-dist-na 21.354 None None None XRAY 3.796 0.286 0.299 B 465 427 8 0 0 3 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7E P36102 252 679 679.0 No_ligand No_ligand Pseudo DFGin 8.593 14.545 None -105.54, -82.28 -61.73, -45.08 66.71, 24.92 201.84, 999.0 57.11, 56.18 out-na out 12.98 Saltbr-na 999.0 HRD-out -76.76, -25.26 -92.98, 20.24 na-out-na SNCaoa out-na ActLoopNT-out 8.953 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -151.67, 137.7 APE9-dihe-na -156.27, 147.39 APE8-dihe-na 50.58, -115.32 APE8-rot-na 999.0 APE67-dihe-na -120.31, 161.36 -52.5, 149.39 APE12-dist-na 10.423 APE11-dist-na 14.399 APE10-dist-na 13.061 APE9-dist-na 22.197 None None None XRAY 3.796 0.286 0.299 E 465 414 14 0 0 4 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7F P36102 228 679 679.0 No_ligand No_ligand Pseudo DFGin 7.335 13.992 None -85.2, -83.41 -116.11, 146.78 -89.94, 10.94 48.78, 999.0 50.83, 40.11 out-na out 14.008 Saltbr-na 999.0 HRD-out -81.05, -16.69 -95.9, 8.11 na-out-na SNCaoa out-na ActLoopNT-out 9.402 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -60.89, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-na 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 999.0, 999.0 APE12-dist-na 14.494 APE11-dist-na 13.254 APE10-dist-na 14.386 APE9-dist-na 999.0 None None None XRAY 3.796 0.286 0.299 F 465 442 10 0 0 9 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7H P36102 250 679 679.0 No_ligand No_ligand Pseudo DFGin 8.68 13.3 None -110.24, -81.52 -76.76, -38.07 62.46, 20.88 310.53, 999.0 54.16, 56.32 out-na out 12.921 Saltbr-na 999.0 HRD-out -76.61, -35.33 -92.88, 18.01 na-out-na SNCaoa out-na ActLoopNT-out 8.498 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -114.22, 105.17 APE9-dihe-na -135.67, 109.97 APE8-dihe-na -101.57, -1.61 APE8-rot-na 999.0 APE67-dihe-na -115.02, 104.33 50.65, 25.81 APE12-dist-na 10.2 APE11-dist-na 15.254 APE10-dist-na 16.073 APE9-dist-na 20.357 None None None XRAY 3.796 0.286 0.299 H 465 420 10 0 0 0 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7I P36102 229 679 679.0 No_ligand No_ligand Pseudo DFGin 8.144 12.434 None -108.56, -80.67 -51.19, -43.4 36.07, 999.0 50.25, 999.0 999.0, 999.0 out-na out 13.826 Saltbr-na 999.0 HRD-out -73.52, 162.17 61.84, 30.5 na-out-na SNCaoa out-na ActLoopNT-out 8.985 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-na 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 999.0, 999.0 APE12-dist-na 14.275 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 3.796 0.286 0.299 I 465 437 14 0 0 12 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7K P36102 232 679 679.0 No_ligand No_ligand Pseudo DFGin 8.867 14.923 None -156.42, 150.14 71.91, -27.38 40.67, 30.2 203.09, 999.0 55.41, 54.89 out-na out 12.902 Saltbr-na 999.0 HRD-out -76.01, -11.95 -99.49, 85.37 na-out-na SNCaoa out-na ActLoopNT-out 9.252 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -146.25, 136.7 APE9-dihe-na -119.48, 142.98 APE8-dihe-na -86.15, 136.33 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 -173.56, 999.0 APE12-dist-na 10.218 APE11-dist-na 14.398 APE10-dist-na 13.329 APE9-dist-na 21.667 None None None XRAY 3.796 0.286 0.299 K 465 430 12 0 0 6 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7L P36102 228 679 679.0 No_ligand No_ligand Pseudo DFGin 6.671 13.685 None -78.56, -72.57 -129.25, 151.61 -94.17, 11.47 47.53, 999.0 54.98, 49.56 out-na out 13.837 Saltbr-na 999.0 HRD-out -78.34, 152.76 -93.5, 19.59 na-out-na SNCaoa out-na ActLoopNT-out 9.654 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-na 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 999.0, 999.0 APE12-dist-na 11.616 APE11-dist-na 10.871 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 3.796 0.286 0.299 L 465 441 11 0 0 10 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 6R5KN P36102 226 679 679.0 No_ligand No_ligand Pseudo DFGin 8.48 14.664 None -120.3, -48.75 -78.43, -46.99 64.41, 6.24 198.56, 999.0 58.24, 31.07 out-na out 14.257 Saltbr-na 999.0 HRD-out -118.35, -63.98 -77.29, 95.53 na-out-na SNCaoa out-na ActLoopNT-out 10.648 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -133.92, 86.09 APE9-dihe-na -148.85, 91.9 APE8-dihe-na 67.7, -5.31 APE8-rot-na 203.89 APE67-dihe-na -67.7, 108.58 -85.15, -39.73 APE12-dist-na 11.007 APE11-dist-na 11.872 APE10-dist-na 10.226 APE9-dist-na 14.942 None None None EM 4.8 999.0 999.0 N 458 427 8 0 0 3 [[284, 397], [394, 557]] 2.0 6r5k Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 3.6e-11 78.1 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 6R5KO P36102 224 679 679.0 No_ligand No_ligand Pseudo DFGin 10.458 15.674 None -78.53, -48.76 -98.61, 103.36 -129.36, 83.07 293.03, 999.0 -139.53, -162.35 out-na out 14.011 Saltbr-na 999.0 HRD-out -70.33, -14.42 -118.0, -56.77 na-out-na SNCaoa out-na ActLoopNT-out 12.355 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-na 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 999.0, 999.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None EM 4.8 999.0 999.0 O 689 443 13 0 0 12 [[284, 397], [394, 557]] 2.0 6r5k Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 2.8e-11 77.9 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER DRIK1 C0P4K9_MAIZE 6CPYA C0P4K9 187 492 514.0 No_ligand No_ligand Pseudo DFGout 11.776 6.56 BBAminus -121.64, 160.64 -140.86, 84.7 -95.49, -21.28 299.11, 170.59 -75.42, 137.84 in-na in 9.978 Saltbr-na 999.0 HRD-na-K -111.28, 14.55 -64.19, -23.9 na-out-none SNCaon out-none ActLoopNT-out 11.451 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.2 0.215 A 308 275 16 0 0 16 [[225, 486]] 1.0 6cpy Zea mays OTHER_DRIK1_MAIZE TKL 7.3e-27 105.8 3 266 264 373 374 375 377 379 254 275 279 353 355 354 356 404 400 395 394 393 392 391 390 389 307 Protein kinase superfamily protein
OTHER DRIK1 C0P4K9_MAIZE 6CPYB C0P4K9 209 492 514.0 No_ligand No_ligand Pseudo DFGout 12.159 6.595 BBAminus -120.65, 156.83 -136.31, 83.57 -95.93, -18.61 296.17, 169.26 -78.78, 140.44 out-na out 10.005 Saltbr-na 999.0 HRD-na-K -106.4, 8.9 -64.04, -23.89 na-out-none SNCaon out-none ActLoopNT-out 11.253 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 65.77 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.2 0.215 B 308 262 22 0 0 15 [[225, 486]] 1.0 6cpy Zea mays OTHER_DRIK1_MAIZE TKL 7.3e-27 105.8 3 266 264 373 374 375 377 379 254 275 279 353 355 354 356 404 400 395 394 393 392 391 390 389 307 Protein kinase superfamily protein
OTHER DRIK1 C0P4K9_MAIZE 6EASA C0P4K9 208 492 514.0 J3A:501 Type1 Pseudo DFGout 11.541 7.261 BBAminus -114.68, 159.09 -139.76, 85.02 -87.45, -32.23 305.52, 172.02 -68.6, 131.12 out-na out 10.055 Saltbr-na 999.0 HRD-na-K -121.01, 9.13 -57.65, -26.71 na-out-none SNCaon out-none ActLoopNT-out 11.598 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.209 0.251 A 308 263 22 0 0 16 [[225, 486]] 1.0 6eas Zea mays OTHER_DRIK1_MAIZE TKL 7.3e-27 105.8 3 266 264 373 374 375 377 379 254 275 279 353 355 354 356 404 400 395 394 393 392 391 390 389 307 Protein kinase superfamily protein
OTHER SIRK1 K7VIQ3_MAIZE 5UV4A K7VIQ3 744 1045 1045.0 ANP:1101 ATPlike Pseudo DFGin 4.878 12.802 BLBplus -120.34, 177.7 46.93, 54.84 -91.14, 142.45 62.71, 98.99 59.6, 31.25 out-out out 15.147 Saltbr-out 17.532 HRD-in -68.43, -62.74 80.25, -5.53 out-out-out SNCooo out-out ActLoopNT-out 7.16 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oioo APE10-dihe-na -63.26, -37.61 APE9-dihe-na -61.51, -44.79 APE8-dihe-out -63.05, -40.24 APE8-rot-none 999.0 APE67-dihe-out 86.33, 22.47 -82.94, -6.82 APE12-dist-out 14.657 APE11-dist-in 12.436 APE10-dist-out 11.85 APE9-dist-out 10.422 None None None XRAY 2.3 0.184 0.211 A 311 290 12 0 0 0 [[757, 1042]] 1.0 5uv4 Zea mays OTHER_SIRK1_MAIZE TKL 1.6e-38 138.7 5 265 261 906 907 908 910 912 789 805 809 885 887 886 888 949 935 930 929 928 927 926 925 924 837 Putative leucine-rich repeat protein kinase family protein

Activity: Pseudo (pseudokinase)

Total number of chains: 76
Active chains: 0
Total number of genes: 18
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 31 40.8% 5GZAA
DFGin BLAminus 10 13.2% 8AK2A
None None 10 13.2% 4M69B
DFGin BLBminus 9 11.8% 6VC0A
DFGin ABAminus 5 6.6% 9QJ2A
DFGout None 5 6.6% 4I93A
DFGout BBAminus 3 3.9% 6CPYA
DFGin BLAplus 2 2.6% 4BTFA
DFGin BLBplus 1 1.3% 5UV4A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
OTHER BIR2 BIR2_ARATH 4L68A Q9LSI9 272 600 605.0 PDO:60701 Allosteric Pseudo DFGin 9.12 13.554 BLBminus -102.75, 164.19 78.08, 3.07 -61.21, 134.13 312.77, 999.0 84.79, -0.01 out-out out 13.782 Saltbr-out 15.36 HRD-in -67.43, -47.03 75.0, -5.42 out-out-out SNCooo out-out ActLoopNT-out 5.938 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nioi APE10-dihe-na -95.05, 4.01 APE9-dihe-na 129.54, -165.7 APE8-dihe-in -116.84, 144.73 APE8-rot-na 179.81 APE67-dihe-inflip 91.69, -13.11 -52.03, 129.52 APE12-dist-none 999.0 APE11-dist-in 11.902 APE10-dist-out 15.357 APE9-dist-in 3.82 None None None XRAY 2.0 0.191 0.213 A 340 313 16 0 0 11 [[306, 577]] 1.0 4l68 Arabidopsis thaliana OTHER_BIR2_ARATH TKL 2.4e-44 157.9 4 266 263 446 447 448 450 452 335 350 354 426 428 427 429 490 478 473 472 471 470 469 468 467 380 Inactive LRR receptor-like serine/threonine-protein kinase BIR2
OTHER BIR2 BIR2_ARATH 4L68B Q9LSI9 271 600 605.0 No_ligand No_ligand Pseudo DFGin 9.495 13.641 BLBminus -104.07, 171.02 73.8, -2.3 -55.39, 130.02 301.68, 999.0 88.64, -4.13 out-out out 13.837 Saltbr-out 15.342 HRD-in -71.67, -49.97 80.05, -2.9 out-out-out SNCooo out-out ActLoopNT-out 6.083 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na -93.83, 137.13 APE9-dihe-na -65.39, -157.74 APE8-dihe-out -87.47, -29.3 APE8-rot-na 172.43 APE67-dihe-out 162.38, 161.42 -146.69, 18.8 APE12-dist-out 22.835 APE11-dist-out 27.482 APE10-dist-out 27.665 APE9-dist-out 31.74 None None None XRAY 2.0 0.191 0.213 B 340 320 10 0 0 10 [[306, 577]] 1.0 4l68 Arabidopsis thaliana OTHER_BIR2_ARATH TKL 2.4e-44 157.9 4 266 263 446 447 448 450 452 335 350 354 426 428 427 429 490 478 473 472 471 470 469 468 467 380 Inactive LRR receptor-like serine/threonine-protein kinase BIR2
OTHER BSK8 BSK8_ARATH 4I94A Q9FHD7 40 328 487.0 ANP:60401 ATPlike Pseudo DFGout 11.087 4.579 None -62.85, 129.32 -64.9, -25.87 -61.66, -30.07 297.42, 140.17 -78.36, -1.16 out-out out 12.492 Saltbr-out 11.168 HRD-na-V -138.88, 128.41 -94.79, 85.21 out-out-out SNCooo out-out ActLoopNT-out 8.116 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -112.72, -1.39 APE9-dihe-na -99.73, 174.6 APE8-dihe-in -44.04, 124.87 APE8-rot-na 191.2 APE67-dihe-in -63.8, -11.97 -65.3, -25.56 APE12-dist-in 9.651 APE11-dist-in 13.035 APE10-dist-out 13.738 APE9-dist-out 9.019 None None None XRAY 1.8 0.176 0.218 A 300 289 0 0 0 0 [[64, 311]] 1.0 4i94 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.8e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER BSK8 BSK8_ARATH 4I94B Q9FHD7 40 328 487.0 ANP:60401 ATPlike Pseudo DFGout 11.167 4.564 None -61.22, 131.83 -70.76, -19.93 -64.01, -28.32 298.7, 142.58 -77.56, -3.78 out-out out 12.61 Saltbr-out 11.562 HRD-na-V -138.23, 125.02 -91.22, 87.17 out-out-out SNCooo out-out ActLoopNT-out 8.121 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -107.48, -5.73 APE9-dihe-na -87.26, 179.81 APE8-dihe-in -41.52, 121.65 APE8-rot-na 191.74 APE67-dihe-in -60.71, -19.43 -60.4, -25.91 APE12-dist-in 9.638 APE11-dist-in 12.966 APE10-dist-out 14.136 APE9-dist-out 9.048 None None None XRAY 1.8 0.176 0.218 B 300 289 0 0 0 0 [[64, 311]] 1.0 4i94 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.8e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER BSK8 BSK8_ARATH 4I92A Q9FHD7 40 328 487.0 No_ligand No_ligand Pseudo DFGout 11.158 4.503 None -61.91, 128.06 -64.53, -19.55 -63.02, -32.76 295.83, 136.16 -71.51, -4.32 out-out out 12.243 Saltbr-out 10.618 HRD-na-V -137.1, 130.87 -99.42, 125.04 out-out-out SNCooo out-out ActLoopNT-out 7.549 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooo APE10-dihe-na -72.8, -24.34 APE9-dihe-na -114.6, 124.96 APE8-dihe-in -57.47, 142.35 APE8-rot-na 288.82 APE67-dihe-in -56.47, -25.62 -59.24, -24.8 APE12-dist-in 12.687 APE11-dist-out 17.668 APE10-dist-out 12.461 APE9-dist-out 8.159 None None None XRAY 1.6 0.161 0.183 A 300 289 0 0 0 0 [[64, 311]] 1.0 4i92 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.8e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER BSK8 BSK8_ARATH 4I93A Q9FHD7 40 328 487.0 No_ligand No_ligand Pseudo DFGout 11.427 4.497 None -66.16, 131.32 -65.62, -20.78 -61.54, -32.08 294.88, 141.88 -71.37, -4.79 out-out out 12.372 Saltbr-out 10.901 HRD-na-V -139.73, 134.34 -102.66, 127.15 out-out-out SNCooo out-out ActLoopNT-out 7.578 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -96.34, -20.96 APE9-dihe-na -65.99, 130.67 APE8-dihe-in -66.24, 142.18 APE8-rot-na 187.32 APE67-dihe-in -58.9, -21.18 -65.5, -18.1 APE12-dist-in 13.821 APE11-dist-in 12.207 APE10-dist-out 13.515 APE9-dist-out 8.198 None None MSE115,MSE135,MSE152,MSE156,MSE203,MSE267,MSE269,MSE310 XRAY 1.5 0.181 0.208 A 300 289 0 0 0 0 [[64, 311]] 1.0 4i93 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.8e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER BSK8 BSK8_ARATH 4I93B Q9FHD7 40 328 487.0 No_ligand No_ligand Pseudo DFGout 11.368 4.478 None -62.63, 134.05 -67.17, -20.35 -61.56, -31.26 298.97, 139.62 -77.7, -1.04 out-out out 12.587 Saltbr-out 11.096 HRD-na-V -145.3, 130.74 -99.64, 132.89 out-out-none SNCoon out-none ActLoopNT-out 8.009 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -52.43 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE115,MSE135,MSE152,MSE156,MSE203,MSE267,MSE269,MSE310 XRAY 1.5 0.181 0.208 B 300 283 6 0 0 6 [[64, 311]] 1.0 4i93 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.8e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER MLKL2 Q9FGG5_ARATH 6LBAA Q9FGG5 1 570 711.0 No_ligand No_ligand Pseudo None 6.73 999.0 None -122.97, 148.56 93.16, 0.89 -63.48, -42.05 51.06, 103.73 -82.35, 163.56 none-none none 999.0 Saltbr-none 999.0 HRD-in -59.59, -40.18 73.95, -60.85 none-out-none SNCnon out-none ActLoopNT-out 10.548 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 151.3 APE8-rot-na 30.21 APE67-dihe-in -62.28, -7.76 -72.46, -6.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 4.1 999.0 999.0 A 572 464 74 0 0 13 [[250, 508]] 1.0 6lba Arabidopsis thaliana OTHER_MLKL2_ARATH TKL 8.1e-39 140.1 20 265 246 382 383 384 386 388 265 277 281 356 358 357 359 433 410 405 404 403 402 401 400 399 309 Protein kinase family protein
OTHER MLKL2 Q9FGG5_ARATH 6LBAB Q9FGG5 1 570 711.0 No_ligand No_ligand Pseudo None 6.731 999.0 None -122.97, 148.57 93.19, 0.89 -63.46, -42.1 51.1, 103.74 -82.32, 163.59 none-none none 999.0 Saltbr-none 999.0 HRD-in -59.59, -40.18 73.9, -60.83 none-out-none SNCnon out-none ActLoopNT-out 10.547 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 151.29 APE8-rot-na 30.18 APE67-dihe-in -62.24, -7.82 -72.49, -6.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 4.1 999.0 999.0 B 572 464 74 0 0 13 [[250, 508]] 1.0 6lba Arabidopsis thaliana OTHER_MLKL2_ARATH TKL 8.1e-39 140.1 20 265 246 382 383 384 386 388 265 277 281 356 358 357 359 433 410 405 404 403 402 401 400 399 309 Protein kinase family protein
OTHER MLKL2 Q9FGG5_ARATH 6LBAC Q9FGG5 1 570 711.0 No_ligand No_ligand Pseudo None 6.731 999.0 None -123.02, 148.57 93.19, 0.88 -63.44, -42.08 51.11, 103.72 -82.32, 163.57 none-none none 999.0 Saltbr-none 999.0 HRD-in -59.58, -40.22 73.99, -60.87 none-out-none SNCnon out-none ActLoopNT-out 10.549 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 151.3 APE8-rot-na 30.19 APE67-dihe-in -62.3, -7.76 -72.5, -6.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 4.1 999.0 999.0 C 572 464 74 0 0 13 [[250, 508]] 1.0 6lba Arabidopsis thaliana OTHER_MLKL2_ARATH TKL 8.1e-39 140.1 20 265 246 382 383 384 386 388 265 277 281 356 358 357 359 433 410 405 404 403 402 401 400 399 309 Protein kinase family protein
OTHER MLKL2 Q9FGG5_ARATH 6LBAD Q9FGG5 1 570 711.0 No_ligand No_ligand Pseudo None 6.73 999.0 None -123.01, 148.57 93.2, 0.79 -63.42, -42.02 51.11, 103.73 -82.4, 163.58 none-none none 999.0 Saltbr-none 999.0 HRD-in -59.58, -40.22 73.98, -60.84 none-out-none SNCnon out-none ActLoopNT-out 10.548 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 151.34 APE8-rot-na 30.2 APE67-dihe-in -62.23, -7.79 -72.5, -6.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 4.1 999.0 999.0 D 572 464 74 0 0 13 [[250, 508]] 1.0 6lba Arabidopsis thaliana OTHER_MLKL2_ARATH TKL 8.1e-39 140.1 20 265 246 382 383 384 386 388 265 277 281 356 358 357 359 433 410 405 404 403 402 401 400 399 309 Protein kinase family protein
OTHER MLKL3 Q9LMN2_ARATH 6KA4A Q9LMN2 325 900 1025.0 No_ligand No_ligand Pseudo None 6.802 999.0 None -142.13, 171.5 85.9, 1.28 -63.61, -40.11 50.83, 88.77 -77.79, 165.1 none-na none 999.0 Saltbr-na 999.0 HRD-out -64.16, 132.9 -63.4, -51.31 na-out-out SNCaoo out-out ActLoopNT-out 9.485 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -117.65 APE8-rot-na 24.5 APE67-dihe-out -127.8, -55.85 -82.83, 72.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 A 701 534 34 0 0 17 [[570, 833]] 1.0 6ka4 Arabidopsis thaliana OTHER_MLKL3_ARATH TKL 3.4e-35 128.8 50 265 216 705 706 707 709 711 0 0 602 677 679 678 680 758 737 732 731 730 729 728 727 726 630 F22L4.1 protein
OTHER MLKL3 Q9LMN2_ARATH 6KA4B Q9LMN2 325 900 1025.0 No_ligand No_ligand Pseudo None 6.802 999.0 None -142.18, 171.46 85.97, 1.26 -63.61, -40.11 50.83, 88.78 -77.79, 165.1 none-na none 999.0 Saltbr-na 999.0 HRD-out -64.14, 132.89 -63.44, -51.21 na-out-out SNCaoo out-out ActLoopNT-out 9.485 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -117.63 APE8-rot-na 24.5 APE67-dihe-out -127.76, -55.87 -82.87, 72.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 B 701 534 34 0 0 17 [[570, 833]] 1.0 6ka4 Arabidopsis thaliana OTHER_MLKL3_ARATH TKL 3.4e-35 128.8 50 265 216 705 706 707 709 711 0 0 602 677 679 678 680 758 737 732 731 730 729 728 727 726 630 F22L4.1 protein
OTHER MLKL3 Q9LMN2_ARATH 6KA4C Q9LMN2 325 900 1025.0 No_ligand No_ligand Pseudo None 6.801 999.0 None -142.14, 171.51 85.88, 1.33 -63.66, -40.1 50.84, 88.73 -77.78, 165.14 none-na none 999.0 Saltbr-na 999.0 HRD-out -64.18, 132.86 -63.33, -51.38 na-out-out SNCaoo out-out ActLoopNT-out 9.485 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -117.58 APE8-rot-na 24.47 APE67-dihe-out -127.78, -55.8 -82.92, 72.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 C 701 534 34 0 0 17 [[570, 833]] 1.0 6ka4 Arabidopsis thaliana OTHER_MLKL3_ARATH TKL 3.4e-35 128.8 50 265 216 705 706 707 709 711 0 0 602 677 679 678 680 758 737 732 731 730 729 728 727 726 630 F22L4.1 protein
OTHER MLKL3 Q9LMN2_ARATH 6KA4D Q9LMN2 325 900 1025.0 No_ligand No_ligand Pseudo None 6.803 999.0 None -142.12, 171.53 85.87, 1.26 -63.58, -40.16 50.84, 88.79 -77.77, 165.1 none-na none 999.0 Saltbr-na 999.0 HRD-out -64.2, 132.96 -63.47, -51.27 na-out-out SNCaoo out-out ActLoopNT-out 9.486 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -117.62 APE8-rot-na 24.59 APE67-dihe-out -127.79, -55.89 -82.86, 72.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 D 701 534 34 0 0 17 [[570, 833]] 1.0 6ka4 Arabidopsis thaliana OTHER_MLKL3_ARATH TKL 3.4e-35 128.8 50 265 216 705 706 707 709 711 0 0 602 677 679 678 680 758 737 732 731 730 729 728 727 726 630 F22L4.1 protein
OTHER STKLD1 F1MSZ0_BOVIN 9FQRXR F1MSZ0 1 610 639.0 No_ligand No_ligand Pseudo DFGin 6.896 13.145 BLBminus -134.69, 167.6 69.62, 51.59 -66.55, 132.48 297.73, 161.29 -107.87, 152.84 out-out out 14.762 Saltbr-out 12.944 HRD-in -60.65, -50.75 79.55, -12.94 out-out-out SNCooo out-out ActLoopNT-out 9.598 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -53.75, -17.84 APE9-dihe-na -83.29, -27.47 APE8-dihe-out -101.65, -16.85 APE8-rot-na 289.97 APE67-dihe-in -73.99, -1.71 -81.73, -21.53 APE12-dist-out 20.029 APE11-dist-out 19.061 APE10-dist-out 22.971 APE9-dist-out 14.584 None None None EM 5.0 999.0 999.0 Xr 756 579 21 0 0 0 [[4, 271]] 1.0 9fqr Bos taurus OTHER_STKLD1_BOVIN STE 3e-31 115.2 5 257 253 150 151 152 154 156 33 49 53 130 132 131 133 192 181 176 175 174 173 172 171 170 85 Serine/threonine kinase like domain containing 1
OTHER PAN3 PAN3_CHATD 4CYIA G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.585 12.852 None -92.38, -13.16 -130.85, 61.75 -94.99, 144.51 286.93, 999.0 79.52, -4.52 out-na out 13.591 Saltbr-na 999.0 HRD-out -83.98, 84.54 -50.92, -35.91 na-out-na SNCaoa out-na ActLoopNT-out 7.062 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -80.88, -42.8 APE9-dihe-na -64.32, -40.93 APE8-dihe-na -99.24, 17.32 APE8-rot-na 300.48 APE67-dihe-na -73.05, -48.17 -58.31, -53.55 APE12-dist-na 4.897 APE11-dist-na 5.543 APE10-dist-na 5.105 APE9-dist-na 11.572 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 A 438 405 0 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIB G0S0Y3 213 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.616 12.918 None -91.62, -15.83 -130.65, 63.54 -94.89, 145.11 286.33, 999.0 77.48, -4.88 out-na out 13.58 Saltbr-na 999.0 HRD-out -84.8, 85.11 -51.08, -35.56 na-out-na SNCaoa out-na ActLoopNT-out 7.175 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -82.17, -41.93 APE9-dihe-na -64.26, -40.58 APE8-dihe-na -98.12, 16.28 APE8-rot-na 298.69 APE67-dihe-na 80.12, -45.62 -60.06, 122.74 APE12-dist-na 4.893 APE11-dist-na 5.478 APE10-dist-na 5.079 APE9-dist-na 11.87 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 B 438 406 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIC G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.492 12.647 None -89.83, -13.71 -129.71, 95.5 -125.66, 144.13 285.48, 999.0 76.65, -4.79 out-na out 13.568 Saltbr-na 999.0 HRD-out -84.9, 84.38 -51.27, -35.99 na-out-na SNCaoa out-na ActLoopNT-out 7.036 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.46, -42.97 APE9-dihe-na -65.29, -40.87 APE8-dihe-na -98.03, 18.1 APE8-rot-na 300.5 APE67-dihe-na -80.64, -42.62 -57.0, -52.24 APE12-dist-na 4.87 APE11-dist-na 5.412 APE10-dist-na 5.104 APE9-dist-na 11.702 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 C 438 397 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYID G0S0Y3 214 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.581 12.83 None -92.56, -14.61 -129.54, 61.33 -91.03, 145.16 286.17, 999.0 78.34, -3.87 out-na out 13.632 Saltbr-na 999.0 HRD-out -84.73, 84.5 -51.45, -36.17 na-out-na SNCaoa out-na ActLoopNT-out 6.98 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -82.5, -42.63 APE9-dihe-na -63.84, -39.93 APE8-dihe-na -97.69, 15.27 APE8-rot-na 300.06 APE67-dihe-na 82.88, -51.63 -61.5, 124.95 APE12-dist-na 4.849 APE11-dist-na 5.59 APE10-dist-na 5.161 APE9-dist-na 11.613 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 D 438 407 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIE G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.538 12.767 None -90.87, -14.73 -130.14, 65.48 -95.4, 143.11 286.9, 999.0 77.19, -4.14 out-na out 13.933 Saltbr-na 999.0 HRD-out -83.54, 85.23 -50.62, -36.04 na-out-na SNCaoa out-na ActLoopNT-out 6.962 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.29, -42.51 APE9-dihe-na -65.13, -42.05 APE8-dihe-na -99.46, 17.91 APE8-rot-na 300.53 APE67-dihe-na -82.88, -16.1 -58.82, -52.89 APE12-dist-na 4.867 APE11-dist-na 5.506 APE10-dist-na 4.99 APE9-dist-na 11.652 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 E 438 394 10 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIF G0S0Y3 213 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.657 12.928 None -90.71, -14.62 -131.6, 64.5 -94.2, 145.33 287.42, 999.0 78.97, -5.05 out-na out 13.619 Saltbr-na 999.0 HRD-out -84.32, 83.81 -51.72, -36.16 na-out-na SNCaoa out-na ActLoopNT-out 7.068 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.37, -43.07 APE9-dihe-na -65.03, -40.26 APE8-dihe-na -97.58, 14.32 APE8-rot-na 301.7 APE67-dihe-na 82.79, -63.67 -61.76, 133.26 APE12-dist-na 4.897 APE11-dist-na 5.471 APE10-dist-na 4.981 APE9-dist-na 11.745 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 F 438 408 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIG G0S0Y3 212 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.345 12.727 None -90.69, -14.9 -130.76, 66.96 -94.98, 143.34 287.45, 999.0 77.29, -3.15 out-na out 13.686 Saltbr-na 999.0 HRD-out -84.86, 86.26 -50.94, -35.45 na-out-na SNCaoa out-na ActLoopNT-out 6.956 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.27, -42.88 APE9-dihe-na -64.53, -40.74 APE8-dihe-na -98.57, 20.38 APE8-rot-na 300.7 APE67-dihe-na -82.95, -50.87 -54.99, -52.34 APE12-dist-na 4.886 APE11-dist-na 5.441 APE10-dist-na 4.99 APE9-dist-na 11.838 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 G 438 397 11 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIH G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.548 12.993 None -92.58, -12.35 -130.21, 41.87 -74.5, 144.28 287.27, 999.0 78.55, -5.47 out-na out 13.565 Saltbr-na 999.0 HRD-out -84.2, 83.95 -50.63, -35.15 na-out-na SNCaoa out-na ActLoopNT-out 7.113 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.74, -43.44 APE9-dihe-na -64.3, -40.98 APE8-dihe-na -98.31, 13.33 APE8-rot-na 300.84 APE67-dihe-na 84.19, -53.66 -61.5, 130.17 APE12-dist-na 4.897 APE11-dist-na 5.551 APE10-dist-na 5.004 APE9-dist-na 11.679 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 H 438 407 7 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJA G0S0Y3 207 630 640.0 ATP:900 ATPlike Pseudo DFGin 8.634 13.143 None -107.98, -0.69 -128.2, 34.36 -65.03, -50.53 266.85, 999.0 -67.72, -27.44 out-na out 13.824 Saltbr-na 999.0 HRD-out -72.25, 117.57 -98.06, -29.9 na-out-na SNCaoa out-na ActLoopNT-out 6.734 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -76.94, -48.66 APE9-dihe-na -63.83, -32.83 APE8-dihe-na -105.44, 19.22 APE8-rot-na 294.5 APE67-dihe-na -75.63, -42.57 -53.51, -50.74 APE12-dist-na 4.896 APE11-dist-na 5.565 APE10-dist-na 4.767 APE9-dist-na 12.093 None None None XRAY 2.59 0.185 0.221 A 438 403 9 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJB G0S0Y3 207 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.657 13.407 None -109.51, -3.14 -128.47, 33.06 -65.31, -51.07 267.08, 999.0 -68.09, -25.9 out-na out 13.607 Saltbr-na 999.0 HRD-out -72.34, 112.57 -93.58, -28.7 na-out-na SNCaoa out-na ActLoopNT-out 6.74 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.81, -47.86 APE9-dihe-na -64.66, -32.92 APE8-dihe-na -101.7, 13.23 APE8-rot-na 292.51 APE67-dihe-na 83.46, -7.05 -62.34, 118.45 APE12-dist-na 4.827 APE11-dist-na 5.687 APE10-dist-na 4.961 APE9-dist-na 11.892 None None None XRAY 2.59 0.185 0.221 B 438 412 10 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJC G0S0Y3 210 632 640.0 ATP:900 ATPlike Pseudo DFGin 8.673 13.164 None -108.29, -3.21 -129.06, 34.16 -64.55, -50.26 267.61, 999.0 -68.23, -27.03 out-na out 13.722 Saltbr-na 999.0 HRD-out -71.32, 109.68 -92.82, -27.84 na-out-na SNCaoa out-na ActLoopNT-out 6.928 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -75.12, -48.05 APE9-dihe-na -64.49, -35.42 APE8-dihe-na -104.77, 18.2 APE8-rot-na 294.69 APE67-dihe-na -54.66, -46.82 -53.38, -67.98 APE12-dist-na 4.886 APE11-dist-na 5.663 APE10-dist-na 4.931 APE9-dist-na 11.895 None None None XRAY 2.59 0.185 0.221 C 438 404 8 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJD G0S0Y3 207 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.73 13.246 None -109.91, -2.89 -127.7, 32.83 -63.98, -50.83 267.28, 999.0 -68.06, -27.82 out-na out 13.683 Saltbr-na 999.0 HRD-out -71.89, 115.33 -92.98, -30.13 na-out-na SNCaoa out-na ActLoopNT-out 6.66 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.1, -45.9 APE9-dihe-na -60.82, -48.55 APE8-dihe-na -95.53, 14.82 APE8-rot-na 272.71 APE67-dihe-na -68.99, -42.68 -59.32, -45.4 APE12-dist-na 4.893 APE11-dist-na 5.689 APE10-dist-na 4.875 APE9-dist-na 11.937 None None None XRAY 2.59 0.185 0.221 D 438 411 11 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER POMK SG196_DANRE 5GZAA Q5U3W1 53 342 347.0 ADP:401,ZZ1:405 ATPlike,Allosteric Pseudo DFGin 5.357 13.174 None -145.49, -53.43 -88.36, 87.6 -105.44, 34.02 303.67, 0.43 -66.19, -35.84 none-na none 999.0 Saltbr-na 999.0 HRD-out -76.02, 100.34 -84.46, -37.81 na-in-out SNCaio in-out ActLoopNT-in 3.176 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iioo APE10-dihe-na -72.0, 131.22 APE9-dihe-na -98.58, 149.02 APE8-dihe-in -137.88, 170.05 APE8-rot-out 49.36 APE67-dihe-out -89.83, -15.07 100.95, 169.89 APE12-dist-in 12.164 APE11-dist-in 13.936 APE10-dist-out 17.359 APE9-dist-out 9.415 None None None XRAY 2.0 0.203 0.218 A 290 290 0 0 0 0 [[72, 335]] 1.0 5gza Danio rerio OTHER_POMK_DANRE POMK 3.3e-138 465.4 1 265 265 224 225 226 228 230 106 120 124 199 201 200 202 278 254 249 248 247 246 245 244 243 148 Protein O-mannose kinase
CAMK OBSCN-1 OBSCN_DROME 8AK3A A8DYP0 3186 3477 4218.0 ADP:63501 ATPlike Pseudo DFGin 5.905 13.485 BLAminus -132.07, -172.8 60.67, 81.34 -101.92, 21.49 307.26, 110.13 -57.27, -33.59 in-in in 7.72 Saltbr-in 2.761 HRD-in -74.37, -46.4 81.73, -14.06 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -140.07, 151.0 APE9-dihe-na 162.46, 172.55 APE8-dihe-in -86.0, 119.15 APE8-rot-na 203.36 APE67-dihe-in -78.57, -5.95 -56.15, -31.0 APE12-dist-in 8.047 APE11-dist-in 10.008 APE10-dist-in 6.691 APE9-dist-in 5.787 None None None XRAY 1.9 0.175 0.208 A 297 292 0 0 0 0 [[3186, 3440], [3897, 4151]] 2.0 8ak3 Drosophila melanogaster CAMK_OBSCN-1_DROME CAMK 2.3e-61 213.3 1 256 256 3325 3326 3327 3329 3331 3215 3230 3234 3303 3305 3304 3306 3364 3352 3347 3346 3345 3344 3343 3342 3341 3260 Protein Obscurin
CAMK OBSCN-1 OBSCN_DROME 8AK2A A8DYP0 3186 3472 4218.0 No_ligand No_ligand Pseudo DFGin 5.977 13.478 BLAminus -134.63, -178.36 66.29, 80.8 -103.79, 23.35 307.44, 112.56 -60.88, -31.91 in-in in 7.823 Saltbr-in 2.898 HRD-in -73.1, -49.0 81.01, -10.4 in-in-in SNCiii in-in ActLoopNT-in 2.932 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -139.39, 154.37 APE9-dihe-na 158.35, 172.94 APE8-dihe-in -85.52, 121.03 APE8-rot-na 202.35 APE67-dihe-in -76.68, -5.09 -59.31, -30.09 APE12-dist-in 8.083 APE11-dist-in 9.959 APE10-dist-in 6.785 APE9-dist-in 5.824 None None None XRAY 1.75 0.175 0.196 A 297 287 0 0 0 0 [[3186, 3440], [3897, 4151]] 2.0 8ak2 Drosophila melanogaster CAMK_OBSCN-1_DROME CAMK 2.3e-61 213.3 1 256 256 3325 3326 3327 3329 3331 3215 3230 3234 3303 3305 3304 3306 3364 3352 3347 3346 3345 3344 3343 3342 3341 3260 Protein Obscurin
OTHER PAN3 PAN3_DROME 4BWPA Q95RR8 379 787 790.0 AN2:1788 ATPlike Pseudo DFGin 8.987 13.294 None -64.87, -46.72 -145.48, 65.79 -71.61, -40.0 313.19, 999.0 -67.11, -37.22 out-na out 16.832 Saltbr-na 999.0 HRD-in -50.58, -30.55 79.2, -55.76 na-out-na SNCaoa out-na ActLoopNT-out 6.698 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -83.44, -6.17 APE9-dihe-na -63.0, 138.21 APE8-dihe-na -120.41, 140.18 APE8-rot-na 194.81 APE67-dihe-na -113.46, 118.54 -59.4, -45.27 APE12-dist-na 5.306 APE11-dist-na 5.827 APE10-dist-na 8.834 APE9-dist-na 12.341 None None None XRAY 3.6 0.222 0.269 A 448 386 23 0 0 0 [[378, 664]] 1.0 4bwp Drosophila melanogaster OTHER_PAN3_DROME PAN3 1.2e-113 385.1 1 288 288 564 565 566 568 570 423 438 442 545 547 546 548 592 582 577 576 575 574 573 572 571 472 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_DROME 4BWPB Q95RR8 379 787 790.0 AN2:1788 ATPlike Pseudo DFGin 9.736 13.981 None -68.02, -47.7 -135.41, 45.28 -65.56, -36.8 296.47, 999.0 -63.81, -39.61 out-na out 16.544 Saltbr-na 999.0 HRD-in -58.26, -35.46 80.55, -56.51 na-out-na SNCaoa out-na ActLoopNT-out 5.962 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -88.2, -6.77 APE9-dihe-na -69.16, 143.64 APE8-dihe-na -96.5, 127.2 APE8-rot-na 212.33 APE67-dihe-na -115.77, 110.79 -63.6, -38.16 APE12-dist-na 4.419 APE11-dist-na 6.01 APE10-dist-na 8.854 APE9-dist-na 11.29 None None None XRAY 3.6 0.222 0.269 B 448 372 26 0 0 0 [[378, 664]] 1.0 4bwp Drosophila melanogaster OTHER_PAN3_DROME PAN3 1.2e-113 385.1 1 288 288 564 565 566 568 570 423 438 442 545 547 546 548 592 582 577 576 575 574 573 572 571 472 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER MLKL F6S337_HORSE 6VC0A F6S337 258 536 543.0 No_ligand No_ligand Pseudo DFGin 4.988 13.881 BLBminus -160.47, -177.36 65.51, 36.37 -58.39, 137.28 318.13, 86.77 58.83, -124.64 in-in in 7.643 Saltbr-in 2.677 HRD-na-E -62.53, -41.81 82.08, -6.9 in-out-out SNCioo out-out ActLoopNT-out 13.362 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -88.0, 120.78 APE9-dihe-na -72.95, 148.97 APE8-dihe-out -64.67, -29.31 APE8-rot-in 286.85 APE67-dihe-in -52.64, -29.19 -53.47, -31.2 APE12-dist-in 12.067 APE11-dist-out 17.622 APE10-dist-out 15.015 APE9-dist-out 13.613 None None None XRAY 2.746 0.175 0.238 A 292 272 7 0 0 7 [[272, 535]] 1.0 6vc0 Equus caballus OTHER_MLKL_HORSE TKL 2.5e-50 177.4 7 266 260 415 416 417 419 421 296 316 320 395 397 396 398 461 447 442 441 440 439 438 437 436 350 Mixed lineage kinase domain like pseudokinase
OTHER MLKL F6S337_HORSE 6VC0B F6S337 258 537 543.0 No_ligand No_ligand Pseudo DFGin 5.138 14.211 BLBminus -147.23, -169.43 57.25, 44.02 -61.21, 135.2 309.04, 84.31 57.69, -129.98 in-in in 7.975 Saltbr-in 3.151 HRD-na-E -65.25, -45.35 82.07, -9.74 in-out-out SNCioo out-out ActLoopNT-out 13.481 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -126.45, 116.02 APE9-dihe-na -51.25, 124.58 APE8-dihe-out -50.77, -33.76 APE8-rot-in 297.7 APE67-dihe-in -54.8, -30.44 -56.98, -22.96 APE12-dist-none 999.0 APE11-dist-out 16.172 APE10-dist-out 15.204 APE9-dist-out 13.714 None None None XRAY 2.746 0.175 0.238 B 292 269 11 0 0 11 [[272, 535]] 1.0 6vc0 Equus caballus OTHER_MLKL_HORSE TKL 2.5e-50 177.4 7 266 260 415 416 417 419 421 296 316 320 395 397 396 398 461 447 442 441 440 439 438 437 436 350 Mixed lineage kinase domain like pseudokinase
OTHER MLKL F6S337_HORSE 6VC0C F6S337 258 541 543.0 No_ligand No_ligand Pseudo DFGin 5.403 14.135 BLBminus -139.49, -162.99 63.64, 39.99 -70.44, 152.53 306.23, 102.18 57.77, 37.75 in-in in 7.883 Saltbr-in 2.77 HRD-na-E -65.22, -39.62 76.85, -6.27 in-out-out SNCioo out-out ActLoopNT-out 13.68 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -63.28, 135.92 APE9-dihe-na -86.15, 145.34 APE8-dihe-out -56.36, -39.87 APE8-rot-in 295.41 APE67-dihe-in -54.7, -29.08 -59.22, -20.61 APE12-dist-in 12.868 APE11-dist-out 17.817 APE10-dist-out 15.143 APE9-dist-out 13.226 None None None XRAY 2.746 0.175 0.238 C 292 271 13 0 0 8 [[272, 535]] 1.0 6vc0 Equus caballus OTHER_MLKL_HORSE TKL 2.5e-50 177.4 7 266 260 415 416 417 419 421 296 316 320 395 397 396 398 461 447 442 441 440 439 438 437 436 350 Mixed lineage kinase domain like pseudokinase
OTHER NFR5-12 Q70KR1_LOTJA 8S79A Q70KR1 280 563 595.0 No_ligand No_ligand Pseudo DFGin 6.7 13.868 BLAminus -141.84, -177.07 52.5, 69.51 -82.54, 22.49 287.3, 79.08 -67.38, -26.68 in-out in 7.718 Saltbr-out 3.649 HRD-in -72.18, -35.12 62.7, 3.73 out-in-none SNCoin in-none ActLoopNT-in 2.851 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.29 0.198 0.231 A 288 284 0 0 0 0 [[319, 463], [457, 560]] 2.0 8s79 Lotus japonicus OTHER_NFR5-12_LOTJA TKL 1.6e-32 157.3 14 150 224 450 451 452 454 456 339 349 353 430 432 431 433 467 0 0 0 0 0 0 0 0 380 Nod-factor receptor 5
OTHER NFR5-12 Q70KR1_LOTJA 8S79B Q70KR1 300 563 595.0 No_ligand No_ligand Pseudo DFGin 6.965 14.233 BLAminus -136.72, 179.37 59.59, 65.64 -81.75, 26.01 290.82, 82.64 -71.44, -48.87 in-out in 9.102 Saltbr-out 6.228 HRD-in -68.14, -46.66 71.86, 0.88 out-in-none SNCoin in-none ActLoopNT-in 2.83 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.29 0.198 0.231 B 288 260 4 0 0 0 [[319, 463], [457, 560]] 2.0 8s79 Lotus japonicus OTHER_NFR5-12_LOTJA TKL 1.6e-32 157.3 14 150 224 450 451 452 454 456 339 349 353 430 432 431 433 467 0 0 0 0 0 0 0 0 380 Nod-factor receptor 5
TKL LYR4 G7K7K0_MEDTR 8PS7B G7K7K0 340 636 660.0 ANP:703 ATPlike Pseudo DFGin 7.768 15.066 BLBminus -155.57, -174.44 55.36, 56.3 -70.81, 152.24 289.97, 66.8 93.85, 156.74 out-out out 15.961 Saltbr-out 14.036 HRD-in -57.6, -55.05 79.6, -10.79 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -72.46, -42.72 APE9-dihe-na -56.2, -52.66 APE8-dihe-out -56.27, -29.69 APE8-rot-out 59.05 APE67-dihe-in -100.31, -14.89 -66.25, -40.12 APE12-dist-in 9.702 APE11-dist-in 13.647 APE10-dist-out 15.243 APE9-dist-out 9.612 None None None XRAY 2.1 0.225 0.269 B 297 274 23 0 0 12 [[360, 633]] 1.0 8ps7 Medicago truncatula TKL_LYR4_MEDTR TKL 4.9e-53 186.3 13 266 254 493 494 495 497 499 379 388 392 473 475 474 476 538 526 521 520 519 518 517 516 515 418 LysM-domain receptor-like kinase
TKL LYR4 G7K7K0_MEDTR 8PS7A G7K7K0 340 636 660.0 ANP:704 ATPlike Pseudo DFGin 7.344 12.491 None -132.7, -71.23 -80.99, 65.77 -101.31, -4.53 43.9, 75.68 -166.17, 141.69 out-out out 12.664 Saltbr-out 13.161 HRD-in -67.54, -63.16 83.85, -10.66 out-out-out SNCooo out-out ActLoopNT-out 9.632 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -64.12, -49.62 APE9-dihe-na -62.67, -34.57 APE8-dihe-out -58.19, -50.78 APE8-rot-in 276.77 APE67-dihe-in -82.12, -28.85 -67.98, -32.83 APE12-dist-out 14.247 APE11-dist-out 19.231 APE10-dist-out 20.4 APE9-dist-out 9.296 None None None XRAY 2.1 0.225 0.269 A 297 279 18 0 0 0 [[360, 633]] 1.0 8ps7 Medicago truncatula TKL_LYR4_MEDTR TKL 4.9e-53 186.3 13 266 254 493 494 495 497 499 379 388 392 473 475 474 476 538 526 521 520 519 518 517 516 515 418 LysM-domain receptor-like kinase
OTHER MLKL MLKL_MOUSE 4M68A Q9D2Y4 182 466 472.0 No_ligand No_ligand Pseudo DFGin 9.852 16.7 BLAplus -129.7, -163.13 77.79, 17.7 -134.64, -18.09 73.34, 102.06 -94.56, 159.05 out-out out 16.505 Saltbr-out 13.3 HRD-na-E -69.29, -48.17 86.0, -11.45 out-out-out SNCooo out-out ActLoopNT-out 11.888 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 128.37 APE9-dihe-na -54.91, -21.63 APE8-dihe-out -63.15, -25.67 APE8-rot-out 40.6 APE67-dihe-in -52.68, -39.76 -124.73, 3.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 25.824 APE9-dist-out 12.948 None None None XRAY 1.696 0.195 0.216 A 283 268 9 0 0 9 [[189, 451]] 1.0 4m68 Mus musculus OTHER_MLKL_MOUSE TKL 2.1e-48 171.1 7 266 260 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_MOUSE 4BTFA Q9D2Y4 2 463 472.0 No_ligand No_ligand Pseudo DFGin 9.681 16.7 BLAplus -133.91, -159.82 79.78, 12.69 -135.05, -21.42 69.63, 92.26 -89.6, 153.33 out-out out 16.15 Saltbr-out 11.221 HRD-na-E -72.28, -47.25 76.21, -2.88 out-out-out SNCooo out-out ActLoopNT-out 12.025 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 154.4 APE8-dihe-out -103.41, -28.46 APE8-rot-in 243.61 APE67-dihe-in -72.27, -11.5 -56.76, -28.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.4 None None None XRAY 2.604 0.209 0.256 A 469 413 8 0 0 8 [[189, 451]] 1.0 4btf Mus musculus OTHER_MLKL_MOUSE TKL 1e-47 169.7 6 266 261 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_MOUSE 4M69B Q9D2Y4 182 466 472.0 No_ligand No_ligand Pseudo None 14.113 18.823 None -93.73, 159.62 -63.02, 163.0 -50.35, -54.58 169.88, 78.24 -71.37, -37.09 out-out out 13.469 Saltbr-out 9.651 HRD-na-E -74.43, -45.05 83.78, -5.4 out-out-out SNCooo out-out ActLoopNT-out 12.232 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 7.21 APE9-dihe-na -94.48, 162.52 APE8-dihe-out -72.69, -20.09 APE8-rot-in 348.33 APE67-dihe-in -64.41, -24.19 -65.78, -12.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.954 APE9-dist-out 14.179 None None None XRAY 2.497 0.222 0.246 B 283 264 13 0 0 13 [[189, 451]] 1.0 4m69 Mus musculus OTHER_MLKL_MOUSE TKL 2.1e-48 171.1 7 266 260 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein
OTHER POMK SG196_MOUSE 5GZ9A Q3TUA9 54 337 349.0 ANP:1001,MAN:1004 ATPlike,Allosteric Pseudo DFGin 5.293 13.023 ABAminus -119.99, -54.35 -93.01, 108.48 -116.58, 23.4 308.09, 4.31 -55.72, -49.95 none-na none 999.0 Saltbr-na 999.0 HRD-out -81.79, 73.24 -60.09, -38.65 na-in-out SNCaio in-out ActLoopNT-in 3.248 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iioo APE10-dihe-na -60.33, 128.48 APE9-dihe-na -97.57, 144.89 APE8-dihe-in -131.17, 161.49 APE8-rot-na 301.17 APE67-dihe-out -101.62, -18.24 97.94, -172.65 APE12-dist-in 12.549 APE11-dist-in 13.729 APE10-dist-out 17.531 APE9-dist-out 9.743 N66Q,N164Q None None XRAY 2.4 0.234 0.268 A 305 280 4 0 0 2 [[73, 337]] 1.0 5gz9 Mus musculus OTHER_POMK_MOUSE POMK 1.2e-147 496.2 1 265 265 225 226 227 229 231 107 121 125 200 202 201 203 280 256 251 250 249 248 247 246 245 149 Protein O-mannose kinase
OTHER POMK SG196_MOUSE 5GZ8A Q3TUA9 54 337 349.0 No_ligand No_ligand Pseudo DFGin 4.936 13.224 ABAminus -117.42, -46.49 -93.1, 109.24 -114.97, 25.11 303.9, 6.2 -83.07, -8.89 none-na none 999.0 Saltbr-na 999.0 HRD-out -78.55, 82.62 -71.19, -27.89 na-in-out SNCaio in-out ActLoopNT-in 3.28 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iooo APE10-dihe-na -71.9, 132.75 APE9-dihe-na -101.64, 147.44 APE8-dihe-in -135.98, 164.92 APE8-rot-na 301.94 APE67-dihe-out -112.69, -14.59 101.92, -170.48 APE12-dist-in 13.032 APE11-dist-out 14.216 APE10-dist-out 18.039 APE9-dist-out 9.704 N66Q,N164Q None None XRAY 2.5 0.274 0.293 A 305 272 12 0 0 4 [[73, 337]] 1.0 5gz8 Mus musculus OTHER_POMK_MOUSE POMK 1.2e-147 496.2 1 265 265 225 226 227 229 231 107 121 125 200 202 201 203 280 256 251 250 249 248 247 246 245 149 Protein O-mannose kinase
OTHER PAN3 PAN3_NEUCR 4BWKA Q7SDP4 235 646 656.0 AGS:1647 ATPlike Pseudo DFGin 8.495 13.09 None -115.86, 18.21 -139.38, 20.36 -67.09, 152.08 286.46, 999.0 74.54, -4.0 out-na out 14.22 Saltbr-na 999.0 HRD-in -64.9, -42.26 69.75, -63.5 na-out-na SNCaoa out-na ActLoopNT-out 6.898 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -56.05, -33.42 APE9-dihe-na -88.79, -48.0 APE8-dihe-na -71.22, -9.91 APE8-rot-na 304.05 APE67-dihe-na -61.19, -29.14 -123.36, 9.46 APE12-dist-na 1.535 APE11-dist-na 4.895 APE10-dist-na 5.205 APE9-dist-na 11.464 None None None XRAY 3.3 0.254 0.294 A 429 392 10 0 0 0 [[258, 516]] 1.0 4bwk Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4 264 261 424 425 426 428 430 302 318 322 405 407 406 408 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4BWKB Q7SDP4 235 646 656.0 AGS:1647 ATPlike Pseudo DFGin 8.098 12.897 None -116.7, 18.5 -139.0, 22.15 -67.02, 151.82 287.13, 999.0 73.49, -6.49 out-na out 13.863 Saltbr-na 999.0 HRD-in -66.71, -43.56 68.66, -62.54 na-out-na SNCaoa out-na ActLoopNT-out 6.901 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -57.01, -33.89 APE9-dihe-na -87.36, -45.86 APE8-dihe-na -67.7, -8.98 APE8-rot-na 303.47 APE67-dihe-na -166.92, 999.0 -122.6, 109.05 APE12-dist-na 1.57 APE11-dist-na 4.926 APE10-dist-na 5.367 APE9-dist-na 12.432 None None None XRAY 3.3 0.254 0.294 B 429 387 14 0 0 5 [[258, 516]] 1.0 4bwk Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4 264 261 424 425 426 428 430 302 318 322 405 407 406 408 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4CZYB Q7SDP4 234 645 656.0 ANP:61650 ATPlike Pseudo DFGin 8.636 12.999 None -108.01, 7.82 -124.9, 18.28 -71.16, 143.54 291.41, 999.0 81.95, -4.35 out-na out 13.97 Saltbr-na 999.0 HRD-in -64.78, -43.28 69.3, -58.59 na-out-na SNCaoa out-na ActLoopNT-out 7.042 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -68.73, -37.24 APE9-dihe-na -75.95, -42.57 APE8-dihe-na -71.33, -35.43 APE8-rot-na 302.88 APE67-dihe-na -61.0, -48.02 -101.37, 21.03 APE12-dist-na 1.544 APE11-dist-na 4.84 APE10-dist-na 5.824 APE9-dist-na 11.769 None None None XRAY 3.4 0.223 0.263 B 429 403 6 0 0 0 [[258, 516]] 1.0 4czy Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4 264 261 424 425 426 428 430 302 318 322 405 407 406 408 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4CZYD Q7SDP4 234 645 656.0 ANP:61650 ATPlike Pseudo DFGin 8.389 12.627 None -108.63, 8.9 -122.37, 20.29 -71.82, 141.42 292.67, 999.0 81.18, -5.38 out-na out 13.908 Saltbr-na 999.0 HRD-in -65.6, -43.11 68.0, -59.39 na-out-na SNCaoa out-na ActLoopNT-out 6.96 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -69.97, -39.27 APE9-dihe-na -74.97, -41.75 APE8-dihe-na -69.88, -35.71 APE8-rot-na 304.18 APE67-dihe-na -59.83, -48.03 -102.6, 21.19 APE12-dist-na 1.535 APE11-dist-na 4.833 APE10-dist-na 5.688 APE9-dist-na 12.012 None None None XRAY 3.4 0.223 0.263 D 429 403 6 0 0 0 [[258, 516]] 1.0 4czy Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4 264 261 424 425 426 428 430 302 318 322 405 407 406 408 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4BWXA Q7SDP4 234 646 656.0 AGS:1647 ATPlike Pseudo DFGin 7.942 12.815 None -114.92, 18.69 -139.36, 20.25 -66.2, 154.39 287.13, 999.0 71.2, -3.87 out-na out 14.696 Saltbr-na 999.0 HRD-in -65.26, -41.46 68.71, -60.85 na-out-na SNCaoa out-na ActLoopNT-out 6.852 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -57.52, -32.86 APE9-dihe-na -89.29, -47.03 APE8-dihe-na -70.13, -10.67 APE8-rot-na 304.73 APE67-dihe-na -61.75, -33.62 -123.15, 12.73 APE12-dist-na 1.538 APE11-dist-na 4.866 APE10-dist-na 5.325 APE9-dist-na 11.917 L510M,G511P,G512M,T514G,T515A,H516R,L517F None None XRAY 2.85 0.213 0.242 A 429 395 10 0 0 0 [[258, 516]] 1.0 4bwx Neurospora crassa OTHER_PAN3_NEUCR PAN3 1.1e-59 210.5 4 282 279 424 425 426 428 430 302 318 322 405 407 406 408 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4BWXB Q7SDP4 234 646 656.0 AGS:1647 ATPlike Pseudo DFGin 8.062 12.942 None -115.89, 18.73 -138.78, 21.11 -66.02, 153.84 287.45, 999.0 70.44, -4.24 out-na out 13.517 Saltbr-na 999.0 HRD-in -64.84, -41.41 68.02, -61.18 na-out-na SNCaoa out-na ActLoopNT-out 6.89 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -59.2, -32.89 APE9-dihe-na -88.22, -46.65 APE8-dihe-na -69.2, -11.95 APE8-rot-na 305.01 APE67-dihe-na -59.96, -34.44 -124.18, 13.25 APE12-dist-na 1.54 APE11-dist-na 4.865 APE10-dist-na 5.361 APE9-dist-na 12.007 L510M,G511P,G512M,T514G,T515A,H516R,L517F None None XRAY 2.85 0.213 0.242 B 429 397 6 0 0 0 [[258, 516]] 1.0 4bwx Neurospora crassa OTHER_PAN3_NEUCR PAN3 1.1e-59 210.5 4 282 279 424 425 426 428 430 302 318 322 405 407 406 408 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
CAMK None A0A3P9GXN4_ORYLA 9QJ2A A0A3P9GXN4 421 763 930.0 No_ligand No_ligand Pseudo DFGin 5.816 14.574 ABAminus -103.19, 10.84 -129.61, 124.02 -134.01, 15.15 279.12, 167.03 -69.28, -18.9 out-out out 10.596 Saltbr-out 4.888 HRD-in -107.62, -60.3 74.68, 7.37 out-in-out SNCoio in-out ActLoopNT-in 3.039 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -147.71, 158.55 APE9-dihe-na -127.68, -75.19 APE8-dihe-in -66.9, 117.12 APE8-rot-in 315.05 APE67-dihe-in -69.37, -21.14 -62.17, -40.52 APE12-dist-in 7.773 APE11-dist-out 7.485 APE10-dist-out 10.656 APE9-dist-out 8.602 None None None XRAY 2.1 0.191 0.227 A 354 343 0 0 0 0 [[450, 704]] 1.0 9qj2 Oryzias latipes CAMK_None_ORYLA CAMK 5.2e-70 241.8 1 256 256 589 590 591 593 595 479 494 498 567 569 568 570 628 616 611 610 609 608 607 606 605 524 Uncharacterized protein
CAMK None A0A3P9GXN4_ORYLA 9QJ2B A0A3P9GXN4 419 763 930.0 No_ligand No_ligand Pseudo DFGin 5.826 14.191 ABAminus -102.09, 8.39 -127.24, 124.79 -133.74, 14.79 279.29, 166.62 -68.97, -21.46 out-out out 10.488 Saltbr-out 4.606 HRD-in -108.31, -59.51 75.34, 10.01 out-in-out SNCoio in-out ActLoopNT-in 3.165 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -146.66, 158.08 APE9-dihe-na -128.06, -75.51 APE8-dihe-in -67.56, 120.62 APE8-rot-in 314.05 APE67-dihe-in -68.38, -18.1 -64.58, -41.57 APE12-dist-in 7.765 APE11-dist-out 7.453 APE10-dist-out 10.829 APE9-dist-out 8.759 None None None XRAY 2.1 0.191 0.227 B 354 345 0 0 0 0 [[450, 704]] 1.0 9qj2 Oryzias latipes CAMK_None_ORYLA CAMK 5.2e-70 241.8 1 256 256 589 590 591 593 595 479 494 498 567 569 568 570 628 616 611 610 609 608 607 606 605 524 Uncharacterized protein
CAMK CASK CSKP_RAT 6LNMA Q62915 6 335 909.0 No_ligand No_ligand Pseudo DFGin 7.679 16.419 BLAminus -125.57, -156.96 71.26, 41.84 -92.26, 21.6 283.61, 82.87 -59.28, -29.43 in-out in 9.775 Saltbr-out 5.421 HRD-in -72.06, -54.7 78.39, -5.65 out-in-in SNCoii in-in ActLoopNT-in 3.014 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.57, 142.02 APE9-dihe-na 103.56, -158.39 APE8-dihe-in -102.42, 124.74 APE8-rot-in 312.47 APE67-dihe-in -61.02, -25.98 -48.73, -46.84 APE12-dist-in 12.437 APE11-dist-in 12.077 APE10-dist-in 6.491 APE9-dist-in 3.887 None None None XRAY 2.4 0.173 0.213 A 351 325 0 0 0 0 [[12, 276]] 1.0 6lnm Rattus norvegicus CAMK_CASK_RAT CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_RAT 6LNMC Q62915 6 335 909.0 No_ligand No_ligand Pseudo DFGin 7.53 16.324 BLAminus -124.57, -155.35 70.57, 43.32 -90.1, 19.87 282.0, 84.55 -58.3, -30.97 in-out in 9.937 Saltbr-out 5.422 HRD-in -71.6, -55.71 80.52, -6.16 out-in-in SNCoii in-in ActLoopNT-in 3.007 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.18, 143.52 APE9-dihe-na 102.38, -158.49 APE8-dihe-in -102.65, 124.64 APE8-rot-in 312.81 APE67-dihe-in -60.4, -25.09 -44.75, -48.44 APE12-dist-in 12.914 APE11-dist-in 12.085 APE10-dist-in 6.512 APE9-dist-in 3.822 None None None XRAY 2.4 0.173 0.213 C 351 322 0 0 0 0 [[12, 276]] 1.0 6lnm Rattus norvegicus CAMK_CASK_RAT CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_RAT 6LNME Q62915 6 335 909.0 No_ligand No_ligand Pseudo DFGin 7.62 16.36 BLAminus -125.56, -155.57 64.88, 45.15 -89.82, 22.17 282.43, 83.22 -56.78, -33.33 in-out in 9.972 Saltbr-out 4.21 HRD-in -66.87, -57.99 76.64, -4.28 out-in-in SNCoii in-in ActLoopNT-in 3.013 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.45, 141.41 APE9-dihe-na 101.35, -152.19 APE8-dihe-in -106.58, 124.03 APE8-rot-in 310.93 APE67-dihe-in -62.75, -26.9 -46.07, -47.51 APE12-dist-in 12.775 APE11-dist-in 12.256 APE10-dist-in 6.605 APE9-dist-in 3.885 None None None XRAY 2.4 0.173 0.213 E 351 322 0 0 0 0 [[12, 276]] 1.0 6lnm Rattus norvegicus CAMK_CASK_RAT CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
OTHER MLKL D3ZKP6_RAT 6VBZA D3ZKP6 183 454 462.0 No_ligand No_ligand Pseudo DFGin 5.806 14.618 BLBminus -127.94, -150.16 82.3, 7.23 -50.29, 129.54 298.11, 127.33 -134.6, 159.72 in-in in 8.01 Saltbr-in 2.839 HRD-na-E -66.14, -44.04 96.84, -17.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -117.57, 160.85 APE9-dihe-na -74.63, 135.58 APE8-dihe-out -62.94, -16.08 APE8-rot-out 71.09 APE67-dihe-in -56.49, -25.33 -62.02, -19.84 APE12-dist-none 999.0 APE11-dist-out 22.777 APE10-dist-out 23.132 APE9-dist-out 14.696 None None None XRAY 2.192 0.184 0.215 A 295 256 16 0 0 16 [[190, 454]] 1.0 6vbz Rattus norvegicus OTHER_MLKL_RAT TKL 1.7e-47 168.1 6 265 260 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein
OTHER MLKL D3ZKP6_RAT 6VBZB D3ZKP6 182 454 462.0 No_ligand No_ligand Pseudo DFGin 6.646 15.8 BLBminus -133.61, 172.11 77.91, 57.02 -87.12, 172.28 304.15, 97.39 -154.58, -167.67 in-in in 7.826 Saltbr-in 2.43 HRD-na-E -68.53, -47.34 101.45, -26.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -138.28, 162.06 APE9-dihe-na -77.74, 131.79 APE8-dihe-out -67.86, -11.53 APE8-rot-out 53.7 APE67-dihe-in -52.65, -30.9 -54.76, -23.09 APE12-dist-none 999.0 APE11-dist-out 27.324 APE10-dist-out 24.958 APE9-dist-out 14.833 None None None XRAY 2.192 0.184 0.215 B 295 256 17 0 0 17 [[190, 454]] 1.0 6vbz Rattus norvegicus OTHER_MLKL_RAT TKL 1.7e-47 168.1 6 265 260 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein
OTHER PRAG1 PRAG1_RAT 6EWXB D3ZMK9 909 1368 1368.0 No_ligand No_ligand Pseudo DFGin 7.219 15.175 BLAminus -133.85, 172.85 70.26, 80.02 -96.45, 35.56 285.38, 96.62 -69.81, -17.12 none-na none 999.0 Saltbr-na 999.0 HRD-in -61.27, -46.37 70.02, 1.75 na-in-out SNCaio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -86.46 APE8-dihe-out 67.61, -127.28 APE8-rot-out 54.05 APE67-dihe-out -107.54, 29.89 -153.58, 137.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 25.306 None None None XRAY 2.771 0.191 0.246 B 484 358 93 0 0 8 [[957, 1297]] 1.0 6ewx Rattus norvegicus OTHER_PRAG1_RAT PEAK 3.5e-151 510.3 1 349 349 1177 1178 1179 1181 1183 997 1007 1011 1116 1118 1117 1119 1215 1204 1199 1198 1197 1196 1195 1194 1193 1067 Inactive tyrosine-protein kinase PRAG1
OTHER PRAG1 PRAG1_RAT 6EWXA D3ZMK9 914 1368 1368.0 No_ligand No_ligand Pseudo None 999.0 14.99 None -138.76, -179.41 62.27, 87.01 -105.89, 29.57 278.96, 90.95 -82.99, -12.61 none-na none 999.0 Saltbr-na 999.0 HRD-in -72.84, -50.42 66.83, 6.91 na-in-none SNCain in-none ActLoopNT-in 3.018 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -124.03, 42.88 999.0, -158.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.771 0.191 0.246 A 484 359 92 0 0 12 [[957, 1297]] 1.0 6ewx Rattus norvegicus OTHER_PRAG1_RAT PEAK 3.5e-151 510.3 1 349 349 1177 1178 1179 1181 1183 997 1007 1011 1116 1118 1117 1119 1215 1204 1199 1198 1197 1196 1195 1194 1193 1067 Inactive tyrosine-protein kinase PRAG1
OTHER CEX1 CEX1_YEAST 3VWAA Q12453 9 544 761.0 No_ligand No_ligand Pseudo DFGin 5.146 12.461 BLAminus -124.7, 158.77 103.54, 84.22 -111.14, 14.82 251.12, 18.37 -50.07, -41.29 in-na in 8.559 Saltbr-na 999.0 HRD-na-- -102.7, -59.87 84.78, -15.06 na-in-none SNCain in-none ActLoopNT-in 2.737 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE193,MSE203,MSE218,MSE266,MSE287,MSE304,MSE317 XRAY 2.2 0.17 0.207 A 560 527 0 0 0 0 [[10, 237]] 1.0 3vwa Saccharomyces cerevisiae OTHER_CEX1_YEAST SCYL 2.5e-12 53.2 6 155 150 151 152 153 155 157 47 62 66 131 133 132 134 0 0 0 0 0 0 0 0 0 93 Cytoplasmic export protein 1
OTHER CEX1 CEX1_YEAST 3VWAB Q12453 9 543 761.0 No_ligand No_ligand Pseudo DFGin 5.005 12.33 BLAminus -123.03, 148.89 124.48, 69.4 -97.56, 25.97 262.87, 13.7 -69.48, -27.98 in-na in 8.454 Saltbr-na 999.0 HRD-na-- -90.47, -61.74 86.81, -14.68 na-in-none SNCain in-none ActLoopNT-in 2.846 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE193,MSE203,MSE218,MSE266,MSE287,MSE304,MSE317 XRAY 2.2 0.17 0.207 B 560 525 0 0 0 0 [[10, 237]] 1.0 3vwa Saccharomyces cerevisiae OTHER_CEX1_YEAST SCYL 2.5e-12 53.2 6 155 150 151 152 153 155 157 47 62 66 131 133 132 134 0 0 0 0 0 0 0 0 0 93 Cytoplasmic export protein 1
OTHER PAN3-12 PAN3_YEAST 4XR7C P36102 227 679 679.0 No_ligand No_ligand Pseudo DFGin 7.563 14.177 ABAminus -101.78, -60.65 -111.32, 143.47 -96.6, 11.04 309.33, 999.0 52.49, 47.95 out-na out 14.562 Saltbr-na 999.0 HRD-out -78.84, -25.1 -93.97, -5.24 na-out-na SNCaoa out-na ActLoopNT-out 8.599 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-na 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 999.0, 999.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 3.796 0.286 0.299 C 465 440 13 0 0 12 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7B P36102 226 679 679.0 No_ligand No_ligand Pseudo DFGin 8.502 15.422 None -104.85, -81.9 -55.51, -45.21 62.67, 17.87 199.85, 999.0 45.47, 46.6 out-na out 13.49 Saltbr-na 999.0 HRD-out -76.12, -16.46 -97.99, 85.58 na-out-na SNCaoa out-na ActLoopNT-out 8.945 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -142.19, 130.31 APE9-dihe-na -74.85, 162.0 APE8-dihe-na -74.39, -32.88 APE8-rot-na 188.94 APE67-dihe-na -124.14, 114.63 -58.03, 146.49 APE12-dist-na 11.287 APE11-dist-na 13.88 APE10-dist-na 13.545 APE9-dist-na 21.354 None None None XRAY 3.796 0.286 0.299 B 465 427 8 0 0 3 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7E P36102 252 679 679.0 No_ligand No_ligand Pseudo DFGin 8.593 14.545 None -105.54, -82.28 -61.73, -45.08 66.71, 24.92 201.84, 999.0 57.11, 56.18 out-na out 12.98 Saltbr-na 999.0 HRD-out -76.76, -25.26 -92.98, 20.24 na-out-na SNCaoa out-na ActLoopNT-out 8.953 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -151.67, 137.7 APE9-dihe-na -156.27, 147.39 APE8-dihe-na 50.58, -115.32 APE8-rot-na 999.0 APE67-dihe-na -120.31, 161.36 -52.5, 149.39 APE12-dist-na 10.423 APE11-dist-na 14.399 APE10-dist-na 13.061 APE9-dist-na 22.197 None None None XRAY 3.796 0.286 0.299 E 465 414 14 0 0 4 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7F P36102 228 679 679.0 No_ligand No_ligand Pseudo DFGin 7.335 13.992 None -85.2, -83.41 -116.11, 146.78 -89.94, 10.94 48.78, 999.0 50.83, 40.11 out-na out 14.008 Saltbr-na 999.0 HRD-out -81.05, -16.69 -95.9, 8.11 na-out-na SNCaoa out-na ActLoopNT-out 9.402 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -60.89, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-na 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 999.0, 999.0 APE12-dist-na 14.494 APE11-dist-na 13.254 APE10-dist-na 14.386 APE9-dist-na 999.0 None None None XRAY 3.796 0.286 0.299 F 465 442 10 0 0 9 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7H P36102 250 679 679.0 No_ligand No_ligand Pseudo DFGin 8.68 13.3 None -110.24, -81.52 -76.76, -38.07 62.46, 20.88 310.53, 999.0 54.16, 56.32 out-na out 12.921 Saltbr-na 999.0 HRD-out -76.61, -35.33 -92.88, 18.01 na-out-na SNCaoa out-na ActLoopNT-out 8.498 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -114.22, 105.17 APE9-dihe-na -135.67, 109.97 APE8-dihe-na -101.57, -1.61 APE8-rot-na 999.0 APE67-dihe-na -115.02, 104.33 50.65, 25.81 APE12-dist-na 10.2 APE11-dist-na 15.254 APE10-dist-na 16.073 APE9-dist-na 20.357 None None None XRAY 3.796 0.286 0.299 H 465 420 10 0 0 0 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7I P36102 229 679 679.0 No_ligand No_ligand Pseudo DFGin 8.144 12.434 None -108.56, -80.67 -51.19, -43.4 36.07, 999.0 50.25, 999.0 999.0, 999.0 out-na out 13.826 Saltbr-na 999.0 HRD-out -73.52, 162.17 61.84, 30.5 na-out-na SNCaoa out-na ActLoopNT-out 8.985 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-na 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 999.0, 999.0 APE12-dist-na 14.275 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 3.796 0.286 0.299 I 465 437 14 0 0 12 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7K P36102 232 679 679.0 No_ligand No_ligand Pseudo DFGin 8.867 14.923 None -156.42, 150.14 71.91, -27.38 40.67, 30.2 203.09, 999.0 55.41, 54.89 out-na out 12.902 Saltbr-na 999.0 HRD-out -76.01, -11.95 -99.49, 85.37 na-out-na SNCaoa out-na ActLoopNT-out 9.252 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -146.25, 136.7 APE9-dihe-na -119.48, 142.98 APE8-dihe-na -86.15, 136.33 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 -173.56, 999.0 APE12-dist-na 10.218 APE11-dist-na 14.398 APE10-dist-na 13.329 APE9-dist-na 21.667 None None None XRAY 3.796 0.286 0.299 K 465 430 12 0 0 6 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 4XR7L P36102 228 679 679.0 No_ligand No_ligand Pseudo DFGin 6.671 13.685 None -78.56, -72.57 -129.25, 151.61 -94.17, 11.47 47.53, 999.0 54.98, 49.56 out-na out 13.837 Saltbr-na 999.0 HRD-out -78.34, 152.76 -93.5, 19.59 na-out-na SNCaoa out-na ActLoopNT-out 9.654 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-na 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 999.0, 999.0 APE12-dist-na 11.616 APE11-dist-na 10.871 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 3.796 0.286 0.299 L 465 441 11 0 0 10 [[284, 397], [394, 557]] 2.0 4xr7 Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 1.5e-11 79.5 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 6R5KN P36102 226 679 679.0 No_ligand No_ligand Pseudo DFGin 8.48 14.664 None -120.3, -48.75 -78.43, -46.99 64.41, 6.24 198.56, 999.0 58.24, 31.07 out-na out 14.257 Saltbr-na 999.0 HRD-out -118.35, -63.98 -77.29, 95.53 na-out-na SNCaoa out-na ActLoopNT-out 10.648 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -133.92, 86.09 APE9-dihe-na -148.85, 91.9 APE8-dihe-na 67.7, -5.31 APE8-rot-na 203.89 APE67-dihe-na -67.7, 108.58 -85.15, -39.73 APE12-dist-na 11.007 APE11-dist-na 11.872 APE10-dist-na 10.226 APE9-dist-na 14.942 None None None EM 4.8 999.0 999.0 N 458 427 8 0 0 3 [[284, 397], [394, 557]] 2.0 6r5k Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 3.6e-11 78.1 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3-12 PAN3_YEAST 6R5KO P36102 224 679 679.0 No_ligand No_ligand Pseudo DFGin 10.458 15.674 None -78.53, -48.76 -98.61, 103.36 -129.36, 83.07 293.03, 999.0 -139.53, -162.35 out-na out 14.011 Saltbr-na 999.0 HRD-out -70.33, -14.42 -118.0, -56.77 na-out-na SNCaoa out-na ActLoopNT-out 12.355 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-na 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-na 999.0, 999.0 999.0, 999.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None EM 4.8 999.0 999.0 O 689 443 13 0 0 12 [[284, 397], [394, 557]] 2.0 6r5k Saccharomyces cerevisiae OTHER_PAN3-12_YEAST PAN3 2.8e-11 77.9 1 114 205 444 445 446 448 450 325 342 346 422 425 423 426 475 465 460 459 458 457 456 455 454 376 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER DRIK1 C0P4K9_MAIZE 6CPYA C0P4K9 187 492 514.0 No_ligand No_ligand Pseudo DFGout 11.776 6.56 BBAminus -121.64, 160.64 -140.86, 84.7 -95.49, -21.28 299.11, 170.59 -75.42, 137.84 in-na in 9.978 Saltbr-na 999.0 HRD-na-K -111.28, 14.55 -64.19, -23.9 na-out-none SNCaon out-none ActLoopNT-out 11.451 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.2 0.215 A 308 275 16 0 0 16 [[225, 486]] 1.0 6cpy Zea mays OTHER_DRIK1_MAIZE TKL 7.3e-27 105.8 3 266 264 373 374 375 377 379 254 275 279 353 355 354 356 404 400 395 394 393 392 391 390 389 307 Protein kinase superfamily protein
OTHER DRIK1 C0P4K9_MAIZE 6CPYB C0P4K9 209 492 514.0 No_ligand No_ligand Pseudo DFGout 12.159 6.595 BBAminus -120.65, 156.83 -136.31, 83.57 -95.93, -18.61 296.17, 169.26 -78.78, 140.44 out-na out 10.005 Saltbr-na 999.0 HRD-na-K -106.4, 8.9 -64.04, -23.89 na-out-none SNCaon out-none ActLoopNT-out 11.253 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 65.77 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.2 0.215 B 308 262 22 0 0 15 [[225, 486]] 1.0 6cpy Zea mays OTHER_DRIK1_MAIZE TKL 7.3e-27 105.8 3 266 264 373 374 375 377 379 254 275 279 353 355 354 356 404 400 395 394 393 392 391 390 389 307 Protein kinase superfamily protein
OTHER DRIK1 C0P4K9_MAIZE 6EASA C0P4K9 208 492 514.0 J3A:501 Type1 Pseudo DFGout 11.541 7.261 BBAminus -114.68, 159.09 -139.76, 85.02 -87.45, -32.23 305.52, 172.02 -68.6, 131.12 out-na out 10.055 Saltbr-na 999.0 HRD-na-K -121.01, 9.13 -57.65, -26.71 na-out-none SNCaon out-none ActLoopNT-out 11.598 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.209 0.251 A 308 263 22 0 0 16 [[225, 486]] 1.0 6eas Zea mays OTHER_DRIK1_MAIZE TKL 7.3e-27 105.8 3 266 264 373 374 375 377 379 254 275 279 353 355 354 356 404 400 395 394 393 392 391 390 389 307 Protein kinase superfamily protein
OTHER SIRK1 K7VIQ3_MAIZE 5UV4A K7VIQ3 744 1045 1045.0 ANP:1101 ATPlike Pseudo DFGin 4.878 12.802 BLBplus -120.34, 177.7 46.93, 54.84 -91.14, 142.45 62.71, 98.99 59.6, 31.25 out-out out 15.147 Saltbr-out 17.532 HRD-in -68.43, -62.74 80.25, -5.53 out-out-out SNCooo out-out ActLoopNT-out 7.16 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oioo APE10-dihe-na -63.26, -37.61 APE9-dihe-na -61.51, -44.79 APE8-dihe-out -63.05, -40.24 APE8-rot-none 999.0 APE67-dihe-out 86.33, 22.47 -82.94, -6.82 APE12-dist-out 14.657 APE11-dist-in 12.436 APE10-dist-out 11.85 APE9-dist-out 10.422 None None None XRAY 2.3 0.184 0.211 A 311 290 12 0 0 0 [[757, 1042]] 1.0 5uv4 Zea mays OTHER_SIRK1_MAIZE TKL 1.6e-38 138.7 5 265 261 906 907 908 910 912 789 805 809 885 887 886 888 949 935 930 929 928 927 926 925 924 837 Putative leucine-rich repeat protein kinase family protein