AGC_PDPK1 (3-phosphoinositide-dependent protein kinase 1)

Total number of chains: 82
Active chains: 28
Uniprot: PDPK1_HUMAN
Kinase Domain Residues: 82 - 342
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 79 96.3% AF-O15530-K1A
DFGout BBAminus 2 2.4% 3NAXA
DFGout None 1 1.2% 3QC4B

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
PDPK1 2BIYA O15530 72 359 556.0 ATP:1373 ATPlike Active DFGin 6.6186 15.0949 BLAminus -141.33, -175.84 82.91, 67.67 -104.99, 1.58 283.05, 104.18 -61.63, -33.06 in-in in 8.6731 Saltbr-in 2.5745 HRD-in -63.52, -52.73 78.44, -11.09 in-in-in SNCiii in-in ActLoopNT-in 2.8201 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.22, 130.12 APE9-dihe-na 106.71, 171.13 APE8-dihe-in -96.94, 126.07 APE8-rot-in 299.07 APE67-dihe-in -62.15, -19.51 -52.23, -44.36 APE12-dist-in 12.8679 APE11-dist-in 12.8691 APE10-dist-in 7.2677 APE9-dist-in 4.7446 S241A None None XRAY 1.95 0.186 0.23 A 310.0 288.0 0 30 30 0 [[82, 342]] 1.0 2biy AGC_PDPK1_HUMAN AGC 1.8e-84 288.8 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3HRCA O15530 76 359 556.0 ATP:1373 ATPlike Active DFGin 6.4861 14.8331 BLAminus -136.91, -178.17 71.81, 74.55 -104.54, 6.98 286.89, 102.51 -65.47, -24.41 in-in in 8.4211 Saltbr-in 3.1591 HRD-in -77.24, -54.93 76.93, -11.42 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.25, 162.0 APE9-dihe-na 130.63, -171.63 APE8-dihe-in -125.01, 129.68 APE8-rot-in 292.48 APE67-dihe-in -58.92, -25.29 -45.32, -48.7 APE12-dist-in 7.4085 APE11-dist-in 10.582 APE10-dist-in 4.9259 APE9-dist-in 3.4793 Y288G,Q292A SEP241 SEP241 XRAY 1.91 0.182 0.207 A 311.0 280.0 4 30 26 4 [[82, 342]] 1.0 3hrc AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 4RRVA O15530 76 359 556.0 ATP:60401 ATPlike Active DFGin 6.5481 14.9984 BLAminus -136.55, -175.99 74.63, 72.8 -106.52, 5.78 286.61, 100.18 -68.12, -17.88 in-in in 8.5198 Saltbr-in 2.956 HRD-in -71.77, -54.29 78.75, -11.73 in-in-in SNCiii in-in ActLoopNT-in 2.9375 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.13, 162.83 APE9-dihe-na 132.08, -169.67 APE8-dihe-in -127.24, 132.02 APE8-rot-in 298.33 APE67-dihe-in -59.21, -24.3 -51.83, -46.04 APE12-dist-in 7.2806 APE11-dist-in 10.5025 APE10-dist-in 4.943 APE9-dist-in 3.5694 Y288G,Q292A SEP241 SEP241 XRAY 1.412 0.135 0.163 A 311.0 284.0 0 30 30 0 [[82, 342]] 1.0 4rrv AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 5ACKA O15530 73 359 556.0 ATP:500 ATPlike Active DFGin 6.6153 14.8606 BLAminus -135.34, 179.84 72.22, 79.01 -106.01, 4.14 287.93, 97.64 -67.02, -18.73 in-in in 8.4184 Saltbr-in 2.5825 HRD-in -74.68, -53.67 78.01, -12.73 in-in-in SNCiii in-in ActLoopNT-in 2.9064 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.4, 162.51 APE9-dihe-na 136.44, -168.07 APE8-dihe-in -132.35, 133.52 APE8-rot-in 296.36 APE67-dihe-in -62.96, -23.95 -54.34, -43.19 APE12-dist-in 7.3257 APE11-dist-in 10.5222 APE10-dist-in 4.9779 APE9-dist-in 3.5575 Y288G,Q292A SEP241 SEP241 XRAY 1.24 0.143 0.166 A 311.0 287.0 0 30 30 0 [[82, 342]] 1.0 5ack AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 5LVPA O15530 75 359 556.0 ATP:500 ATPlike Active DFGin 6.3028 14.9979 BLAminus -144.92, -168.82 66.06, 77.78 -108.23, 11.17 281.99, 93.22 -63.04, -32.41 in-in in 9.539 Saltbr-in 3.1581 HRD-in -77.47, -51.83 79.92, -12.48 in-in-in SNCiii in-in ActLoopNT-in 2.8481 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.64, 166.02 APE9-dihe-na 141.61, 177.5 APE8-dihe-in -123.02, 134.29 APE8-rot-in 296.02 APE67-dihe-in -68.65, -16.53 -46.89, -50.92 APE12-dist-in 7.9068 APE11-dist-in 10.6706 APE10-dist-in 5.166 APE9-dist-in 3.7049 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 A 311.0 276.0 9 30 21 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 5LVPB O15530 74 359 556.0 ATP:401 ATPlike Active DFGin 6.3283 14.5498 BLAminus -137.23, -179.71 80.14, 74.16 -105.47, 15.38 295.0, 84.83 -59.91, -31.47 in-in in 9.2741 Saltbr-in 3.3024 HRD-in -80.68, -44.41 73.96, -16.23 in-in-in SNCiii in-in ActLoopNT-in 2.7443 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.8, 152.43 APE9-dihe-na 134.43, -173.75 APE8-dihe-in -120.09, 128.28 APE8-rot-in 302.93 APE67-dihe-in -67.56, -25.72 -44.99, -47.55 APE12-dist-in 7.8719 APE11-dist-in 11.0112 APE10-dist-in 5.3751 APE9-dist-in 3.7868 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 B 311.0 277.0 9 30 21 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 5LVPC O15530 75 359 556.0 ATP:401 ATPlike Active DFGin 6.3906 14.6076 BLAminus -132.15, -176.81 71.98, 84.02 -116.53, 7.62 291.47, 90.46 -60.24, -24.5 in-in in 9.3044 Saltbr-in 3.0866 HRD-in -75.92, -52.06 78.45, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.8228 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.81, 168.64 APE9-dihe-na 131.92, -176.79 APE8-dihe-in -126.79, 133.21 APE8-rot-in 299.13 APE67-dihe-in -67.64, -15.8 -51.62, -50.49 APE12-dist-in 7.6523 APE11-dist-in 10.8632 APE10-dist-in 5.1235 APE9-dist-in 3.6447 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 C 311.0 276.0 9 30 21 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 5LVPD O15530 74 359 556.0 ATP:500 ATPlike Active DFGin 6.3336 14.4328 BLAminus -146.99, -174.22 74.22, 81.56 -113.84, 4.02 287.97, 93.59 -56.11, -25.73 in-in in 9.3044 Saltbr-in 3.2517 HRD-in -82.38, -50.18 78.4, -12.51 in-in-in SNCiii in-in ActLoopNT-in 2.8357 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.65, 165.17 APE9-dihe-na 129.1, -166.82 APE8-dihe-in -132.84, 129.79 APE8-rot-in 300.06 APE67-dihe-in -65.46, -17.03 -48.9, -48.47 APE12-dist-in 8.2282 APE11-dist-in 10.8909 APE10-dist-in 5.3485 APE9-dist-in 3.6459 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 D 311.0 277.0 9 30 21 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 4CT2A O15530 75 359 556.0 ATP:500 ATPlike Active DFGin 6.5509 14.8668 BLAminus -136.23, -174.98 70.54, 70.07 -102.02, 6.41 290.69, 95.78 -63.73, -21.59 in-in in 8.2523 Saltbr-in 2.6427 HRD-in -73.2, -54.84 77.37, -9.78 in-in-in SNCiii in-in ActLoopNT-in 2.9649 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.02, 163.59 APE9-dihe-na 137.39, -170.05 APE8-dihe-in -132.12, 131.72 APE8-rot-in 295.26 APE67-dihe-in -63.06, -17.27 -51.84, -45.87 APE12-dist-in 7.1628 APE11-dist-in 10.5242 APE10-dist-in 4.9787 APE9-dist-in 3.5273 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A SEP241 SEP241 XRAY 1.25 0.194 0.226 A 311.0 280.0 5 30 30 0 [[82, 342]] 1.0 4ct2 AGC_PDPK1_HUMAN AGC 9.5e-84 286.4 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 5MRDA O15530 76 359 556.0 ATP:405 ATPlike Active DFGin 6.4288 14.7004 BLAminus -133.69, -177.11 74.21, 73.9 -105.88, 9.0 289.39, 99.64 -68.32, -19.62 in-in in 8.3463 Saltbr-in 2.6673 HRD-in -74.32, -53.19 77.26, -10.58 in-in-in SNCiii in-in ActLoopNT-in 2.9416 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.86, 160.68 APE9-dihe-na 136.11, -166.87 APE8-dihe-in -131.1, 132.63 APE8-rot-in 296.36 APE67-dihe-in -62.36, -23.28 -53.02, -44.84 APE12-dist-in 7.3524 APE11-dist-in 10.4975 APE10-dist-in 4.9095 APE9-dist-in 3.5424 K76S,L113V,I118V,I119N,V124I,T128Q,R131K,T148C SEP241 SEP241 XRAY 1.41 0.142 0.174 A 310.0 284.0 0 30 30 0 [[82, 342]] 1.0 5mrd AGC_PDPK1_HUMAN AGC 1.7e-83 285.6 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3HRFA O15530 75 359 556.0 ATP:1373,P47:1374 ATPlike,Allosteric Active DFGin 6.5137 14.7842 BLAminus -133.77, -176.11 75.25, 77.12 -110.83, 6.58 287.55, 100.98 -63.85, -22.79 in-in in 8.3869 Saltbr-in 2.7006 HRD-in -73.67, -53.98 76.59, -10.73 in-in-in SNCiii in-in ActLoopNT-in 2.9232 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.42, 166.15 APE9-dihe-na 124.75, -165.6 APE8-dihe-in -127.97, 128.5 APE8-rot-in 295.31 APE67-dihe-in -62.28, -24.12 -44.34, -47.42 APE12-dist-in 7.3513 APE11-dist-in 10.5457 APE10-dist-in 4.8669 APE9-dist-in 3.4806 Y288G,Q292A SEP241 SEP241 XRAY 1.9 0.165 0.177 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 3hrf AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 4A06A O15530 75 359 556.0 ATP:500,A06:600 ATPlike,Allosteric Active DFGin 6.5121 14.757 BLAminus -135.73, -177.17 74.25, 74.67 -110.25, 11.82 284.97, 101.73 -68.23, -22.46 in-in in 8.3192 Saltbr-in 2.8636 HRD-in -73.73, -51.84 74.62, -10.07 in-in-in SNCiii in-in ActLoopNT-in 2.9204 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.65, 165.25 APE9-dihe-na 128.95, -173.35 APE8-dihe-in -120.15, 131.51 APE8-rot-in 299.31 APE67-dihe-in -59.46, -27.29 -45.75, -47.91 APE12-dist-in 7.336 APE11-dist-in 10.4473 APE10-dist-in 4.8734 APE9-dist-in 3.5088 Y288G,Q292A SEP241 SEP241 XRAY 2.0 0.161 0.198 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 4a06 AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 4AW0A O15530 75 359 556.0 ATP:500,MJF:600 ATPlike,Allosteric Active DFGin 6.5313 14.9926 BLAminus -134.84, 177.25 78.73, 76.19 -106.3, 8.53 283.51, 97.11 -69.63, -19.36 in-in in 8.5954 Saltbr-in 3.0091 HRD-in -83.05, -53.03 79.45, -12.94 in-in-in SNCiii in-in ActLoopNT-in 2.9336 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.69, 159.04 APE9-dihe-na 139.48, -167.8 APE8-dihe-in -131.87, 132.42 APE8-rot-in 295.45 APE67-dihe-in -61.29, -25.28 -54.74, -42.17 APE12-dist-in 7.5089 APE11-dist-in 10.6011 APE10-dist-in 5.0264 APE9-dist-in 3.5797 Y288G,Q292A SEP241 SEP241,CME260 XRAY 1.43 0.171 0.188 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 4aw0 AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 4AW1A O15530 66 359 556.0 ATP:1360,21O:1361 ATPlike,Allosteric Active DFGin 6.325 14.155 BLAminus -137.24, -178.23 68.96, 84.69 -105.37, 17.06 286.01, 86.79 -62.77, -26.7 in-in in 8.5758 Saltbr-in 2.8639 HRD-in -81.18, -54.06 78.32, -13.29 in-in-in SNCiii in-in ActLoopNT-in 2.8487 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.98, 160.2 APE9-dihe-na 130.22, -162.57 APE8-dihe-in -126.98, 128.72 APE8-rot-in 295.96 APE67-dihe-in -57.45, -24.35 -48.01, -47.7 APE12-dist-in 7.6532 APE11-dist-in 10.8523 APE10-dist-in 5.0751 APE9-dist-in 3.5856 Y288G,Q292A SEP241 SEP241 XRAY 1.68 0.165 0.186 A 311.0 287.0 5 30 25 5 [[82, 342]] 1.0 4aw1 AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 4RQKA O15530 74 359 556.0 ATP:403,R1S:404 ATPlike,Allosteric Active DFGin 6.4608 14.7857 BLAminus -139.06, -177.03 75.27, 72.83 -105.25, 7.36 287.3, 98.33 -64.7, -21.38 in-in in 8.4643 Saltbr-in 2.9412 HRD-in -73.98, -52.31 74.79, -9.31 in-in-in SNCiii in-in ActLoopNT-in 2.8799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.64, 164.69 APE9-dihe-na 126.87, -171.23 APE8-dihe-in -124.75, 130.48 APE8-rot-in 298.57 APE67-dihe-in -59.79, -23.66 -48.31, -47.88 APE12-dist-in 7.2437 APE11-dist-in 10.4657 APE10-dist-in 4.9176 APE9-dist-in 3.5437 Y288G,Q292A SEP241 SEP241 XRAY 1.55 0.133 0.167 A 311.0 286.0 0 30 30 0 [[82, 342]] 1.0 4rqk AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 4RQVA O15530 71 359 556.0 ATP:405,R2S:406 ATPlike,Allosteric Active DFGin 6.4916 14.9536 BLAminus -139.41, -174.88 74.87, 69.78 -102.0, 7.85 285.85, 94.73 -65.11, -21.56 in-in in 8.2557 Saltbr-in 2.7717 HRD-in -72.94, -52.57 74.87, -10.5 in-in-in SNCiii in-in ActLoopNT-in 2.9156 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.07, 164.19 APE9-dihe-na 130.69, -171.7 APE8-dihe-in -126.67, 130.74 APE8-rot-in 297.63 APE67-dihe-in -61.47, -23.77 -49.17, -46.26 APE12-dist-in 7.2532 APE11-dist-in 10.4876 APE10-dist-in 4.9687 APE9-dist-in 3.5133 Y288G,Q292A SEP241 SEP241 XRAY 1.502 0.133 0.166 A 311.0 289.0 0 30 30 0 [[82, 342]] 1.0 4rqv AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 5LVOA O15530 73 359 556.0 ATP:401,78W:402 ATPlike,Allosteric Active DFGin 6.581 15.0047 BLAminus -134.78, 179.9 79.12, 70.17 -103.55, 0.25 286.72, 100.66 -64.63, -19.63 in-in in 8.5884 Saltbr-in 2.6313 HRD-in -71.89, -54.41 77.65, -9.82 in-in-in SNCiii in-in ActLoopNT-in 2.9194 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.78, 162.52 APE9-dihe-na 134.75, -167.11 APE8-dihe-in -130.46, 134.12 APE8-rot-in 296.12 APE67-dihe-in -62.26, -22.94 -53.92, -45.37 APE12-dist-in 7.4502 APE11-dist-in 10.5584 APE10-dist-in 4.9836 APE9-dist-in 3.5527 Y288G,Q292A SEP241 SEP241 XRAY 1.09 0.136 0.157 A 311.0 287.0 0 30 30 0 [[82, 342]] 1.0 5lvo AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 4XX9A O15530 71 359 556.0 ATP:401,RF4:402,RF4:403 ATPlike,Allosteric,Allosteric Active DFGin 6.5134 14.9881 BLAminus -138.47, -176.21 74.83, 73.76 -104.66, 7.86 282.59, 98.49 -68.99, -20.43 in-in in 8.4422 Saltbr-in 2.9225 HRD-in -73.71, -50.51 73.32, -9.3 in-in-in SNCiii in-in ActLoopNT-in 2.8949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.41, 162.37 APE9-dihe-na 129.79, -167.49 APE8-dihe-in -129.09, 132.1 APE8-rot-in 295.95 APE67-dihe-in -59.66, -23.23 -49.94, -47.34 APE12-dist-in 7.3717 APE11-dist-in 10.5754 APE10-dist-in 4.9467 APE9-dist-in 3.5452 Y288G,Q292A SEP241 SEP241 XRAY 1.4 0.13 0.165 A 310.0 289.0 0 30 30 0 [[82, 342]] 1.0 4xx9 AGC_PDPK1_HUMAN AGC 6.8e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 4A07A O15530 75 359 556.0 ATP:500,AZ7:600,AZ7:700 ATPlike,Allosteric,Allosteric Active DFGin 6.6546 14.7523 BLAminus -135.35, -178.9 76.01, 72.4 -108.94, 8.63 286.31, 98.68 -64.37, -21.88 in-in in 8.6213 Saltbr-in 2.919 HRD-in -76.19, -54.82 80.07, -12.14 in-in-in SNCiii in-in ActLoopNT-in 2.9107 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.16, 162.52 APE9-dihe-na 132.15, -164.48 APE8-dihe-in -133.89, 130.56 APE8-rot-in 295.87 APE67-dihe-in -62.13, -24.83 -47.31, -46.9 APE12-dist-in 7.3216 APE11-dist-in 10.4272 APE10-dist-in 4.9977 APE9-dist-in 3.5816 Y288G,Q292A SEP241 SEP241,CSS260 XRAY 1.85 0.161 0.2 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 4a07 AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 8DQTA O15530 70 359 556.0 U35:401,U35:402,U35:403 Allosteric,Allosteric,Allosteric Active DFGin 6.5386 15.228 BLAminus -137.99, -177.67 76.39, 75.41 -107.03, 7.63 286.75, 95.91 -68.77, -18.63 in-in in 8.5573 Saltbr-in 2.9067 HRD-in -74.31, -48.93 74.07, -13.37 in-in-in SNCiii in-in ActLoopNT-in 2.9489 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.2, 161.34 APE9-dihe-na 132.87, -165.96 APE8-dihe-in -131.33, 133.45 APE8-rot-in 295.53 APE67-dihe-in -61.71, -24.62 -51.87, -45.17 APE12-dist-in 7.2521 APE11-dist-in 10.4342 APE10-dist-in 4.9085 APE9-dist-in 3.5907 Y288G,Q292A SEP241 SEP241 XRAY 1.31 0.2 0.224 A 311.0 290.0 0 30 30 0 [[82, 342]] 1.0 8dqt AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3OTUA O15530 77 359 556.0 J30:1,BI4:360 Allosteric,Type1.5_Front Active DFGin 6.407 14.9865 BLAminus -147.19, -166.49 62.44, 61.65 -95.64, 10.19 290.91, 105.88 -63.28, -24.6 in-in in 8.3704 Saltbr-in 3.3366 HRD-in -67.23, -53.13 82.11, -16.93 in-in-in SNCiii in-in ActLoopNT-in 2.7953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.97, 157.81 APE9-dihe-na 151.4, -176.81 APE8-dihe-in -123.26, 126.19 APE8-rot-in 294.94 APE67-dihe-in -53.95, -30.51 -40.25, -53.87 APE12-dist-in 7.7118 APE11-dist-in 10.3288 APE10-dist-in 5.2437 APE9-dist-in 4.1303 T148C SEP241 SEP241 XRAY 2.101 0.197 0.24 A 316.0 277.0 6 30 25 5 [[82, 342]] 1.0 3otu AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 AF-O15530-K1A O15530 74 350 556.0 No_ligand No_ligand Active DFGin 6.307 14.7525 BLAminus -134.14, -175.03 67.73, 56.76 -81.0, 7.09 290.02, 100.1 -62.73, -31.75 in-in in 8.4785 Saltbr-in 2.6917 HRD-in -71.22, -49.98 68.85, -15.49 in-in-in SNCiii in-in ActLoopNT-in 2.9019 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.76, 160.45 APE9-dihe-na 125.82, -178.56 APE8-dihe-in -110.7, 135.78 APE8-rot-in 301.58 APE67-dihe-in -71.92, -18.9 -54.44, -36.21 APE12-dist-in 7.4783 APE11-dist-in 10.7463 APE10-dist-in 5.0363 APE9-dist-in 3.4837 None None None AF2 -1.0 1.0 1.0 A 277.0 277.0 0 30 30 0 [[82, 342]] 1.0 AF-O15530-K1 AGC_PDPK1_HUMAN AGC 8.4e-85 289.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 AF-O15530-K3A O15530 74 350 556.0 No_ligand No_ligand Active DFGin 6.0234 14.6473 BLAminus -139.54, -179.29 63.97, 66.91 -82.88, 11.22 294.97, 97.73 -59.7, -35.74 in-in in 8.7295 Saltbr-in 2.6551 HRD-in -73.34, -47.9 67.59, -9.95 in-in-in SNCiii in-in ActLoopNT-in 2.8048 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.66, 143.7 APE9-dihe-na 124.83, 164.09 APE8-dihe-in -82.81, 130.45 APE8-rot-in 291.03 APE67-dihe-in -71.92, -16.19 -51.02, -35.4 APE12-dist-in 8.3871 APE11-dist-in 11.0601 APE10-dist-in 5.2904 APE9-dist-in 4.3622 None None None AF2 -1.0 1.0 1.0 A 277.0 277.0 0 30 30 0 [[82, 342]] 1.0 AF-O15530-K3 AGC_PDPK1_HUMAN AGC 8.4e-85 289.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3SC1A O15530 73 359 556.0 3S1:900 Type1 Active DFGin 6.4332 14.1153 BLAminus -125.85, 175.62 82.13, 80.63 -113.39, 8.45 290.85, 87.77 -53.07, -47.22 in-in in 8.7083 Saltbr-in 3.2163 HRD-in -72.93, -48.81 80.48, -8.67 in-in-in SNCiii in-in ActLoopNT-in 2.8508 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.12, -172.48 APE9-dihe-na 115.93, 147.74 APE8-dihe-in -93.61, 137.68 APE8-rot-in 299.7 APE67-dihe-in -55.26, -32.91 -54.79, -48.8 APE12-dist-in 8.7388 APE11-dist-in 10.6062 APE10-dist-in 5.4107 APE9-dist-in 3.9864 None SEP241 SEP241 XRAY 2.7 0.2 0.237 A 311.0 279.0 8 30 22 8 [[82, 342]] 1.0 3sc1 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3RCJA O15530 77 358 556.0 3RC:0 Type1 Active DFGin 6.5504 14.3915 BLAminus -128.99, -167.62 59.76, 67.13 -93.27, 12.1 286.78, 86.8 -60.54, -37.27 in-in in 8.539 Saltbr-in 2.7862 HRD-in -65.85, -49.34 77.48, -8.62 in-in-in SNCiii in-in ActLoopNT-in 2.8766 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.08, 164.56 APE9-dihe-na 127.57, -173.24 APE8-dihe-in -123.98, 130.3 APE8-rot-in 296.56 APE67-dihe-in -63.09, -20.07 -49.59, -44.96 APE12-dist-in 7.8304 APE11-dist-in 10.7456 APE10-dist-in 5.0252 APE9-dist-in 3.6456 Y288G,Q292A SEP241 SEP241 XRAY 1.7 0.217 0.198 A 311.0 282.0 0 30 30 0 [[82, 342]] 1.0 3rcj AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 5LVLA O15530 74 359 556.0 537:401 Type1 Active DFGin 6.5959 14.602 BLAminus -130.64, -179.01 78.07, 78.29 -107.64, 5.9 287.24, 98.42 -64.3, -24.0 in-in in 8.2927 Saltbr-in 2.5582 HRD-in -74.44, -52.48 78.34, -12.89 in-in-in SNCiii in-in ActLoopNT-in 2.9059 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.91, 163.01 APE9-dihe-na 134.48, -168.83 APE8-dihe-in -131.23, 133.97 APE8-rot-in 296.05 APE67-dihe-in -61.17, -24.01 -50.83, -47.55 APE12-dist-in 7.3206 APE11-dist-in 10.4705 APE10-dist-in 4.8806 APE9-dist-in 3.5651 Y288G,Q292A SEP241 SEP241 XRAY 1.4 0.154 0.178 A 311.0 286.0 0 30 30 0 [[82, 342]] 1.0 5lvl AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 5LVMA O15530 76 359 556.0 ADE:401 Type1 Active DFGin 6.5146 14.8576 BLAminus -134.29, -178.73 78.5, 76.19 -107.92, 3.05 284.81, 100.85 -68.49, -15.39 in-in in 8.3988 Saltbr-in 2.9222 HRD-in -74.83, -53.98 76.68, -6.53 in-in-in SNCiii in-in ActLoopNT-in 2.9138 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.77, 160.72 APE9-dihe-na 136.54, -165.87 APE8-dihe-in -131.32, 134.23 APE8-rot-in 298.42 APE67-dihe-in -62.0, -21.56 -53.2, -46.03 APE12-dist-in 7.4265 APE11-dist-in 10.5567 APE10-dist-in 4.9493 APE9-dist-in 3.5336 Y288G,Q292A SEP241 SEP241 XRAY 1.26 0.135 0.155 A 311.0 284.0 0 30 30 0 [[82, 342]] 1.0 5lvm AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 5LVNA O15530 75 359 556.0 ADN:402 Type1 Active DFGin 6.4926 14.7837 BLAminus -138.56, -175.41 73.41, 75.09 -105.63, 5.44 285.54, 101.95 -63.79, -19.6 in-in in 8.4347 Saltbr-in 2.7393 HRD-in -74.59, -52.51 78.18, -12.02 in-in-in SNCiii in-in ActLoopNT-in 2.8995 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.48, 161.66 APE9-dihe-na 136.02, -164.27 APE8-dihe-in -134.21, 135.25 APE8-rot-in 295.47 APE67-dihe-in -61.9, -23.15 -53.94, -45.84 APE12-dist-in 7.4385 APE11-dist-in 10.5331 APE10-dist-in 4.8932 APE9-dist-in 3.5664 Y288G,Q292A SEP241 SEP241 XRAY 1.379 0.135 0.162 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 5lvn AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 1H1WA O15530 71 359 556.0 ATP:1373 ATPlike Inactive DFGin 6.6116 14.931 BLAminus -145.26, -169.97 71.92, 72.18 -105.82, -0.04 289.27, 102.08 -58.33, -31.92 in-in in 8.5808 Saltbr-in 2.7103 HRD-in -71.45, -48.32 74.08, -8.04 in-in-out SNCiio in-out ActLoopNT-in 2.8395 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.69, 112.94 APE9-dihe-na -63.98, -168.66 APE8-dihe-in -54.13, 124.0 APE8-rot-in 301.59 APE67-dihe-in -62.54, -19.03 -38.83, -50.46 APE12-dist-in 8.922 APE11-dist-out 5.528 APE10-dist-out 10.2978 APE9-dist-in 3.7994 None SEP241 SEP241 XRAY 2.0 0.196 0.223 A 289.0 285.0 4 30 26 4 [[82, 342]] 1.0 1h1w AGC_PDPK1_HUMAN AGC 9.8e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3ORXA O15530 75 359 556.0 1F8:1 Allosteric Inactive DFGin 6.5961 14.1691 BLAminus -138.52, -175.65 62.9, 74.02 -93.7, 13.51 275.9, 89.61 -62.84, -23.94 in-in in 8.8135 Saltbr-in 2.5558 HRD-in -68.79, -51.77 77.65, -2.64 in-in-out SNCiio in-out ActLoopNT-in 2.8365 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -110.22, 106.38 APE9-dihe-na -61.01, -163.77 APE8-dihe-in -59.2, 130.87 APE8-rot-in 313.64 APE67-dihe-in -68.86, -21.58 -48.76, -40.32 APE12-dist-in 9.226 APE11-dist-out 5.7837 APE10-dist-out 10.5309 APE9-dist-in 3.9835 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 A 316.0 284.0 1 30 29 1 [[82, 342]] 1.0 3orx AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3ORXB O15530 77 359 556.0 1F8:1 Allosteric Inactive DFGin 6.6597 14.1548 BLAminus -140.69, -175.67 59.43, 71.11 -92.21, 14.29 279.78, 86.28 -63.72, -16.63 in-in in 8.802 Saltbr-in 2.5641 HRD-in -68.32, -50.05 78.21, -3.88 in-in-out SNCiio in-out ActLoopNT-in 2.8222 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -111.03, 106.62 APE9-dihe-na -60.26, -162.55 APE8-dihe-in -59.71, 131.44 APE8-rot-in 313.93 APE67-dihe-in -67.3, -21.72 -51.61, -39.66 APE12-dist-in 9.2384 APE11-dist-out 5.8005 APE10-dist-out 10.5524 APE9-dist-in 3.9081 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 B 316.0 281.0 2 30 28 2 [[82, 342]] 1.0 3orx AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3ORXC O15530 75 359 556.0 1F8:1 Allosteric Inactive DFGin 6.6298 14.0961 BLAminus -135.92, -176.39 63.79, 71.64 -93.36, 13.73 280.67, 86.49 -62.67, -20.94 in-in in 8.7824 Saltbr-in 2.5509 HRD-in -66.06, -52.0 76.42, -2.2 in-in-out SNCiio in-out ActLoopNT-in 2.8354 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -110.22, 106.64 APE9-dihe-na -60.77, -161.89 APE8-dihe-in -59.91, 131.8 APE8-rot-in 311.89 APE67-dihe-in -63.47, -22.82 -49.61, -43.91 APE12-dist-in 9.1653 APE11-dist-out 5.8015 APE10-dist-out 10.55 APE9-dist-in 3.9841 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 C 316.0 284.0 1 30 29 1 [[82, 342]] 1.0 3orx AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3ORXD O15530 76 359 556.0 1F8:1 Allosteric Inactive DFGin 6.5711 14.146 BLAminus -134.45, -170.09 60.8, 71.91 -91.57, 12.91 278.05, 86.51 -67.5, -17.43 in-in in 8.7987 Saltbr-in 2.5834 HRD-in -66.01, -50.34 77.25, -1.95 in-in-out SNCiio in-out ActLoopNT-in 2.8418 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -110.2, 105.71 APE9-dihe-na -59.39, -160.44 APE8-dihe-in -60.94, 132.03 APE8-rot-in 313.43 APE67-dihe-in -67.95, -22.9 -52.31, -39.76 APE12-dist-in 9.2273 APE11-dist-out 5.7904 APE10-dist-out 10.5469 APE9-dist-in 3.9121 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 D 316.0 283.0 1 30 29 1 [[82, 342]] 1.0 3orx AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3ORXE O15530 76 359 556.0 1F8:1 Allosteric Inactive DFGin 6.3816 14.9206 BLAminus -125.38, -158.75 61.49, 56.01 -85.03, 10.36 279.31, 82.03 -55.13, -32.27 in-in in 9.2368 Saltbr-in 3.2715 HRD-in -67.18, -49.37 73.61, -2.74 in-in-out SNCiio in-out ActLoopNT-in 2.9678 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -112.75, 120.85 APE9-dihe-na -80.18, -170.48 APE8-dihe-in -52.91, 130.32 APE8-rot-in 309.26 APE67-dihe-in -61.57, -27.92 -56.84, -38.07 APE12-dist-none 999.0 APE11-dist-out 5.4882 APE10-dist-out 10.2693 APE9-dist-in 4.4822 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 E 316.0 274.0 10 30 20 10 [[82, 342]] 1.0 3orx AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3ORXF O15530 75 359 556.0 1F8:1 Allosteric Inactive DFGin 6.3677 14.9155 BLAminus -124.96, -165.04 64.25, 56.63 -90.23, 13.81 273.61, 91.31 -58.82, -32.5 in-none in 9.2317 Saltbr-none 999.0 HRD-in -66.95, -49.19 76.54, -9.89 none-in-out SNCnio in-out ActLoopNT-in 2.9816 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -112.23, 117.01 APE9-dihe-na -74.75, -174.06 APE8-dihe-in -40.45, 117.92 APE8-rot-in 309.94 APE67-dihe-in -62.78, -29.13 -41.21, -44.42 APE12-dist-in 8.1177 APE11-dist-out 5.4885 APE10-dist-out 10.2748 APE9-dist-in 4.4634 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 F 316.0 275.0 10 30 20 10 [[82, 342]] 1.0 3orx AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3ORXG O15530 75 359 556.0 1F8:1 Allosteric Inactive DFGin 6.4182 15.1625 BLAminus -124.35, -160.11 59.71, 58.4 -85.01, 8.33 270.63, 86.47 -58.24, -35.05 in-in in 9.2322 Saltbr-in 3.2566 HRD-in -66.57, -49.64 76.01, -6.1 in-in-out SNCiio in-out ActLoopNT-in 3.0259 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.59, 119.71 APE9-dihe-na -80.06, -167.69 APE8-dihe-in -52.92, 132.86 APE8-rot-in 313.01 APE67-dihe-in -62.53, -35.87 -56.69, -38.23 APE12-dist-in 8.4931 APE11-dist-out 5.4816 APE10-dist-out 10.2289 APE9-dist-in 4.3614 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 G 316.0 275.0 10 30 20 10 [[82, 342]] 1.0 3orx AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3ORXH O15530 75 359 556.0 1F8:1 Allosteric Inactive DFGin 6.4702 14.8365 BLAminus -123.34, -162.32 62.45, 60.25 -89.76, 14.7 283.48, 85.4 -55.85, -32.26 in-in in 9.2345 Saltbr-in 3.2833 HRD-in -67.42, -48.8 75.62, -9.07 in-in-out SNCiio in-out ActLoopNT-in 2.9802 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -112.9, 122.93 APE9-dihe-na -81.65, -170.32 APE8-dihe-in -53.77, 133.41 APE8-rot-in 303.61 APE67-dihe-in -61.23, -30.63 -57.13, -39.02 APE12-dist-in 8.3784 APE11-dist-out 5.4961 APE10-dist-out 10.1982 APE9-dist-in 4.4177 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 H 316.0 275.0 10 30 20 10 [[82, 342]] 1.0 3orx AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3ORZA O15530 74 359 556.0 2A2:1,BI4:360 Allosteric,Type1 Inactive DFGin 6.6225 14.6052 BLAminus -134.96, -167.36 70.2, 66.13 -101.26, 0.99 293.7, 88.7 -61.05, -29.24 in-in in 8.2152 Saltbr-in 2.8103 HRD-in -65.12, -49.46 75.7, -10.07 in-in-out SNCiio in-out ActLoopNT-in 2.8327 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -134.38, 111.86 APE9-dihe-na -60.27, -174.97 APE8-dihe-in -55.74, 132.42 APE8-rot-in 303.15 APE67-dihe-in -56.98, -32.17 -55.27, -42.37 APE12-dist-in 11.5493 APE11-dist-out 6.544 APE10-dist-out 10.866 APE9-dist-in 4.1173 T148C SEP241 SEP241 XRAY 2.0 0.22 0.265 A 316.0 277.0 9 30 21 9 [[82, 342]] 1.0 3orz AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3ORZB O15530 73 359 556.0 2A2:1,BI4:360 Allosteric,Type1 Inactive DFGin 6.6476 14.7764 BLAminus -139.38, -168.66 74.13, 69.92 -111.18, 3.04 284.6, 93.64 -63.39, -24.83 in-in in 8.2923 Saltbr-in 2.7592 HRD-in -64.66, -48.81 76.86, -10.42 in-in-out SNCiio in-out ActLoopNT-in 2.8659 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.43, 114.97 APE9-dihe-na -62.67, -167.65 APE8-dihe-in -63.67, 131.38 APE8-rot-in 299.84 APE67-dihe-in -54.64, -32.97 -56.45, -39.98 APE12-dist-in 11.638 APE11-dist-out 6.3971 APE10-dist-out 10.7873 APE9-dist-in 4.0869 T148C SEP241 SEP241 XRAY 2.0 0.22 0.265 B 316.0 279.0 8 30 22 8 [[82, 342]] 1.0 3orz AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3ORZC O15530 74 359 556.0 2A2:1,BI4:360 Allosteric,Type1 Inactive DFGin 6.6668 14.6791 BLAminus -134.07, -170.51 76.79, 69.39 -110.34, 1.38 287.93, 89.81 -56.71, -30.43 in-in in 8.2245 Saltbr-in 2.8037 HRD-in -64.4, -49.76 78.61, -9.94 in-in-out SNCiio in-out ActLoopNT-in 2.8049 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -134.53, 111.0 APE9-dihe-na -58.83, -174.56 APE8-dihe-in -56.66, 132.63 APE8-rot-in 302.29 APE67-dihe-in -56.84, -32.58 -55.43, -42.03 APE12-dist-in 11.7307 APE11-dist-out 6.55 APE10-dist-out 10.875 APE9-dist-in 4.0824 T148C SEP241 SEP241 XRAY 2.0 0.22 0.265 C 316.0 277.0 9 30 21 9 [[82, 342]] 1.0 3orz AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3ORZD O15530 73 359 556.0 2A2:1,BI4:360 Allosteric,Type1 Inactive DFGin 6.6487 14.7735 BLAminus -139.63, -168.42 74.39, 69.06 -110.33, 3.29 285.32, 93.06 -63.48, -24.84 in-in in 8.3101 Saltbr-in 2.754 HRD-in -64.65, -47.43 73.97, -9.52 in-in-out SNCiio in-out ActLoopNT-in 2.8768 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -126.78, 121.12 APE9-dihe-na -63.33, -166.44 APE8-dihe-in -63.66, 131.18 APE8-rot-in 301.29 APE67-dihe-in -54.43, -33.46 -55.31, -40.36 APE12-dist-in 11.5839 APE11-dist-out 6.4058 APE10-dist-out 10.8417 APE9-dist-in 4.0404 T148C SEP241 SEP241 XRAY 2.0 0.22 0.265 D 316.0 279.0 8 30 22 8 [[82, 342]] 1.0 3orz AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 1Z5MA O15530 74 359 556.0 LI8:501 Type1 Inactive DFGin 6.9657 14.6691 BLAminus -143.06, -166.04 70.1, 70.4 -106.54, 10.63 285.55, 95.37 -57.95, -38.82 in-in in 8.979 Saltbr-in 2.8616 HRD-in -60.53, -42.76 63.99, 3.89 in-in-out SNCiio in-out ActLoopNT-in 2.6826 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -142.8, 123.87 APE9-dihe-na -69.98, -168.75 APE8-dihe-in -47.59, 126.16 APE8-rot-in 298.44 APE67-dihe-in -75.58, -18.39 -37.0, -46.81 APE12-dist-in 8.5442 APE11-dist-out 6.2855 APE10-dist-out 10.4569 APE9-dist-in 4.0502 None SEP241 SEP241 XRAY 2.17 0.232 0.269 A 286.0 276.0 10 30 20 10 [[82, 342]] 1.0 1z5m AGC_PDPK1_HUMAN AGC 9.4e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 2PE0A O15530 74 359 556.0 39Z:501 Type1 Inactive DFGin 6.4474 14.3844 BLAminus -129.98, -179.46 78.75, 74.81 -106.99, 5.13 286.59, 90.93 -55.7, -29.7 in-in in 8.7227 Saltbr-in 2.7831 HRD-in -72.01, -55.71 78.26, -0.88 in-in-out SNCiio in-out ActLoopNT-in 2.8174 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.01, 133.16 APE9-dihe-na -80.12, -143.18 APE8-dihe-in -90.02, 137.86 APE8-rot-in 307.83 APE67-dihe-in -64.54, -15.21 -51.36, -49.75 APE12-dist-in 9.1401 APE11-dist-out 5.5127 APE10-dist-out 10.1028 APE9-dist-in 3.7888 None SEP241 SEP241 XRAY 2.35 0.202 0.24 A 286.0 276.0 10 30 20 10 [[82, 342]] 1.0 2pe0 AGC_PDPK1_HUMAN AGC 9.4e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 2PE1A O15530 74 359 556.0 517:501 Type1 Inactive DFGin 6.6447 14.6824 BLAminus -139.4, -175.86 73.15, 71.4 -105.21, 7.65 286.89, 93.63 -52.89, -40.97 in-in in 8.8829 Saltbr-in 2.5948 HRD-in -69.74, -56.95 81.13, 2.35 in-in-out SNCiio in-out ActLoopNT-in 2.8564 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -114.84, 143.11 APE9-dihe-na -79.47, -134.7 APE8-dihe-in -90.68, 136.03 APE8-rot-in 300.98 APE67-dihe-in -68.92, -11.38 -43.74, -52.34 APE12-dist-in 9.1167 APE11-dist-out 5.7014 APE10-dist-out 10.3798 APE9-dist-in 3.6055 None SEP241 SEP241 XRAY 2.14 0.224 0.282 A 286.0 276.0 10 30 20 10 [[82, 342]] 1.0 2pe1 AGC_PDPK1_HUMAN AGC 9.4e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 2PE2A O15530 74 359 556.0 464:501 Type1 Inactive DFGin 6.5908 14.4155 BLAminus -135.75, -175.91 78.63, 72.01 -109.62, 0.43 287.28, 93.19 -54.2, -35.84 in-in in 8.5622 Saltbr-in 2.5509 HRD-in -75.76, -49.83 75.8, -8.69 in-in-out SNCiio in-out ActLoopNT-in 2.7244 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.61, 128.36 APE9-dihe-na -70.67, -166.57 APE8-dihe-in -59.34, 134.44 APE8-rot-in 302.45 APE67-dihe-in -67.69, -11.47 -51.51, -47.62 APE12-dist-in 8.9817 APE11-dist-out 5.5266 APE10-dist-out 10.3125 APE9-dist-in 3.7381 None SEP241 SEP241 XRAY 2.13 0.189 0.215 A 286.0 276.0 10 30 20 10 [[82, 342]] 1.0 2pe2 AGC_PDPK1_HUMAN AGC 9.4e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3NUSA O15530 73 358 556.0 JNZ:374 Type1 Inactive DFGin 6.6661 14.0143 BLAminus -134.94, -176.79 67.79, 79.24 -106.97, 14.51 293.69, 91.17 -56.65, -43.75 in-in in 8.6145 Saltbr-in 3.1048 HRD-in -75.65, -54.6 82.78, -6.2 in-in-out SNCiio in-out ActLoopNT-in 2.8741 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -129.47, 126.95 APE9-dihe-na -67.17, -145.64 APE8-dihe-in -85.86, 130.62 APE8-rot-in 299.93 APE67-dihe-in -70.26, -18.43 -47.43, -45.34 APE12-dist-in 9.4758 APE11-dist-out 6.257 APE10-dist-out 10.2994 APE9-dist-in 4.0295 None SEP241 SEP241 XRAY 2.75 0.177 0.236 A 286.0 277.0 9 30 21 9 [[82, 342]] 1.0 3nus AGC_PDPK1_HUMAN AGC 9.4e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3NUUA O15530 73 358 556.0 JOZ:361 Type1 Inactive DFGin 6.8153 14.418 BLAminus -135.1, 176.45 77.67, 76.35 -106.62, 4.54 289.58, 95.96 -54.87, -35.17 in-in in 8.6632 Saltbr-in 2.6457 HRD-in -75.97, -55.36 84.01, -8.4 in-in-out SNCiio in-out ActLoopNT-in 2.8245 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -123.64, 126.08 APE9-dihe-na -69.19, -150.37 APE8-dihe-in -79.82, 127.26 APE8-rot-in 298.22 APE67-dihe-in -66.17, -14.72 -39.18, -51.46 APE12-dist-in 8.929 APE11-dist-out 5.8492 APE10-dist-out 10.298 APE9-dist-in 3.9915 None SEP241 SEP241 XRAY 1.98 0.189 0.239 A 286.0 277.0 9 30 21 9 [[82, 342]] 1.0 3nuu AGC_PDPK1_HUMAN AGC 9.4e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3NUYA O15530 73 358 556.0 JPZ:370 Type1 Inactive DFGin 6.7298 14.5499 BLAminus -136.81, -175.62 72.08, 77.54 -106.37, 8.07 285.95, 95.42 -50.93, -42.82 in-in in 8.7638 Saltbr-in 2.731 HRD-in -78.09, -53.76 79.66, -9.09 in-in-out SNCiio in-out ActLoopNT-in 2.8966 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.52, 118.04 APE9-dihe-na -67.36, -159.8 APE8-dihe-in -67.79, 132.38 APE8-rot-in 304.86 APE67-dihe-in -62.4, -17.72 -54.87, -44.81 APE12-dist-in 9.4109 APE11-dist-out 5.8201 APE10-dist-out 10.2784 APE9-dist-in 3.9709 None SEP241 SEP241 XRAY 2.1 0.187 0.225 A 286.0 277.0 9 30 21 9 [[82, 342]] 1.0 3nuy AGC_PDPK1_HUMAN AGC 9.4e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 1UU9A O15530 72 357 556.0 BI3:1370 Type1 Inactive DFGin 6.6788 14.783 BLAminus -137.61, -169.2 68.82, 72.55 -103.82, -0.34 285.88, 98.86 -59.49, -32.23 in-in in 8.3257 Saltbr-in 2.6975 HRD-in -73.71, -52.28 77.02, -6.6 in-in-out SNCiio in-out ActLoopNT-in 2.8778 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.15, 123.88 APE9-dihe-na -73.46, -162.02 APE8-dihe-in -55.23, 126.59 APE8-rot-in 305.35 APE67-dihe-in -59.52, -20.56 -41.52, -52.97 APE12-dist-in 9.3386 APE11-dist-out 5.5023 APE10-dist-out 10.2727 APE9-dist-in 3.7767 None SEP241 SEP241 XRAY 1.95 0.176 0.224 A 286.0 277.0 9 30 21 9 [[82, 342]] 1.0 1uu9 AGC_PDPK1_HUMAN AGC 9.4e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 1UVRA O15530 71 359 556.0 BI8:1372 Type1 Inactive DFGin 6.5811 14.4064 BLAminus -141.7, -169.27 62.75, 72.58 -105.41, 8.55 300.9, 81.55 -59.95, -35.71 in-in in 8.5947 Saltbr-in 2.9835 HRD-in -62.43, -49.82 76.81, -6.44 in-in-out SNCiio in-out ActLoopNT-in 2.9337 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -133.17, 120.18 APE9-dihe-na -60.87, -168.42 APE8-dihe-in -53.67, 135.35 APE8-rot-in 308.99 APE67-dihe-in -63.6, -1.85 -44.81, -56.98 APE12-dist-in 7.2881 APE11-dist-out 6.6429 APE10-dist-out 10.6143 APE9-dist-in 4.0897 None SEP241 SEP241 XRAY 2.81 0.176 0.248 A 289.0 285.0 4 30 26 4 [[82, 342]] 1.0 1uvr AGC_PDPK1_HUMAN AGC 9.8e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3NUNA O15530 71 358 556.0 JMZ:361 Type1 Inactive DFGin 6.4722 14.2209 BLAminus -136.64, 178.66 75.33, 84.73 -114.4, 16.28 293.69, 90.85 -60.42, -36.06 in-in in 8.6724 Saltbr-in 2.7874 HRD-in -68.71, -51.25 77.84, -3.6 in-in-out SNCiio in-out ActLoopNT-in 2.8357 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.38, 127.64 APE9-dihe-na -69.91, -151.05 APE8-dihe-in -80.37, 125.09 APE8-rot-in 310.77 APE67-dihe-in -66.15, -18.43 -42.77, -46.09 APE12-dist-in 8.9686 APE11-dist-out 5.8965 APE10-dist-out 10.4173 APE9-dist-in 4.3142 None SEP241 SEP241 XRAY 2.2 0.18 0.227 A 292.0 279.0 9 30 21 9 [[82, 342]] 1.0 3nun AGC_PDPK1_HUMAN AGC 1e-84 289.6 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 2XCHA O15530 73 359 556.0 CKG:1360 Type1 Inactive DFGin 6.7339 14.5287 BLAminus -129.58, 177.2 73.14, 77.15 -102.2, 9.9 285.13, 96.86 -57.37, -39.89 in-in in 8.6981 Saltbr-in 2.571 HRD-in -76.48, -53.27 78.53, -7.84 in-in-out SNCiio in-out ActLoopNT-in 2.893 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.55, 124.18 APE9-dihe-na -77.48, -153.81 APE8-dihe-in -63.6, 127.96 APE8-rot-in 306.17 APE67-dihe-in -61.93, -18.13 -48.28, -49.39 APE12-dist-in 9.2863 APE11-dist-out 5.6905 APE10-dist-out 10.3423 APE9-dist-in 3.8907 None SEP241 SEP241 XRAY 2.0 0.191 0.226 A 309.0 279.0 8 30 22 8 [[82, 342]] 1.0 2xch AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 5HKMA O15530 76 358 556.0 61Y:403 Type1 Inactive DFGin 6.428 14.1502 BLAminus -122.57, -157.08 51.69, 73.85 -100.67, 14.09 281.12, 81.43 -62.59, -33.63 in-in in 8.6492 Saltbr-in 2.8074 HRD-in -66.63, -45.86 63.42, -2.09 in-in-out SNCiio in-out ActLoopNT-in 2.7614 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -140.98, 122.73 APE9-dihe-na -75.89, -160.0 APE8-dihe-in -62.57, 122.86 APE8-rot-in 309.65 APE67-dihe-in -56.46, -24.28 -29.66, -64.05 APE12-dist-in 9.6471 APE11-dist-out 5.8023 APE10-dist-out 10.2714 APE9-dist-in 3.7976 None SEP241 SEP241 XRAY 2.1 0.228 0.273 A 309.0 273.0 10 30 20 10 [[82, 342]] 1.0 5hkm AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 5HNGA O15530 71 359 556.0 62O:403 Type1 Inactive DFGin 6.5015 14.356 BLAminus -131.37, -170.36 61.15, 71.88 -92.77, 10.44 287.92, 92.83 -55.25, -43.3 in-in in 8.828 Saltbr-in 2.8729 HRD-in -61.06, -47.37 70.67, -1.21 in-in-out SNCiio in-out ActLoopNT-in 2.7991 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.82, 119.15 APE9-dihe-na -68.32, -153.72 APE8-dihe-in -67.95, 131.45 APE8-rot-in 305.81 APE67-dihe-in -63.0, -22.16 -48.07, -47.57 APE12-dist-in 9.0259 APE11-dist-out 5.7457 APE10-dist-out 10.5212 APE9-dist-in 4.0322 None SEP241 SEP241 XRAY 3.01 0.176 0.243 A 309.0 281.0 8 30 22 8 [[82, 342]] 1.0 5hng AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 5HO7A O15530 71 359 556.0 63L:701 Type1 Inactive DFGin 6.4996 13.9982 BLAminus -138.45, -177.98 79.97, 72.22 -103.24, 8.72 293.52, 91.58 -60.99, -44.96 in-in in 8.5843 Saltbr-in 3.0686 HRD-in -62.96, -39.76 64.33, -4.25 in-in-out SNCiio in-out ActLoopNT-in 2.9376 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.91, 120.25 APE9-dihe-na -71.94, -150.13 APE8-dihe-in -74.96, 128.19 APE8-rot-in 303.71 APE67-dihe-in -61.52, -27.36 -46.49, -48.45 APE12-dist-in 9.4591 APE11-dist-out 6.0158 APE10-dist-out 10.3175 APE9-dist-in 4.1229 None SEP241 SEP241 XRAY 3.0 0.175 0.233 A 309.0 281.0 8 30 22 8 [[82, 342]] 1.0 5ho7 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 5HO8A O15530 71 358 556.0 63E:701 Type1 Inactive DFGin 6.3257 13.7271 BLAminus -137.78, 179.62 80.28, 69.7 -100.25, 11.3 296.62, 94.66 -58.72, -47.18 in-in in 8.7434 Saltbr-in 3.0233 HRD-in -65.39, -42.86 64.55, -6.55 in-in-out SNCiio in-out ActLoopNT-in 2.8667 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.41, 121.86 APE9-dihe-na -70.34, -152.74 APE8-dihe-in -66.74, 122.4 APE8-rot-in 293.45 APE67-dihe-in -65.08, -24.35 -41.28, -45.91 APE12-dist-in 9.1451 APE11-dist-out 5.9265 APE10-dist-out 10.2379 APE9-dist-in 4.0594 None SEP241 SEP241 XRAY 2.7 0.184 0.229 A 309.0 279.0 9 30 21 9 [[82, 342]] 1.0 5ho8 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 1OKYA O15530 72 360 556.0 STU:1368 Type1 Inactive DFGin 6.1532 14.4616 BLAminus -148.97, -170.84 70.56, 80.45 -102.75, 23.82 286.84, 96.04 -69.28, -20.21 in-in in 8.6718 Saltbr-in 2.6729 HRD-in -67.69, -57.78 80.28, 0.43 in-in-out SNCiio in-out ActLoopNT-in 2.9341 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.7, -80.59 APE9-dihe-na 115.49, 169.91 APE8-dihe-in -54.49, 123.73 APE8-rot-in 316.76 APE67-dihe-in -63.35, -17.55 -42.07, -50.54 APE12-dist-in 9.2892 APE11-dist-out 5.5558 APE10-dist-out 9.7186 APE9-dist-in 4.222 None SEP241 SEP241 XRAY 2.3 0.219 0.255 A 310.0 283.0 6 30 24 6 [[82, 342]] 1.0 1oky AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 1OKZA O15530 73 359 556.0 UCN:1370 Type1 Inactive DFGin 6.5441 14.1675 BLAminus -141.57, -164.78 67.55, 76.85 -103.78, 11.05 287.85, 85.4 -63.67, 2.06 in-in in 8.7271 Saltbr-in 2.7175 HRD-in -70.44, -54.0 75.32, 3.69 in-in-out SNCiio in-out ActLoopNT-in 2.9208 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -147.16, 105.01 APE9-dihe-na -62.12, -140.62 APE8-dihe-in -78.85, 125.76 APE8-rot-in 304.75 APE67-dihe-in -63.07, -21.46 -38.09, -52.99 APE12-dist-in 9.5567 APE11-dist-out 6.099 APE10-dist-out 10.4075 APE9-dist-in 4.1656 None SEP241 SEP241 XRAY 2.51 0.19 0.257 A 310.0 278.0 9 30 21 9 [[82, 342]] 1.0 1okz AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 1UU3A O15530 73 360 556.0 LY4:1374 Type1 Inactive DFGin 6.5956 14.9714 BLAminus -134.47, -173.45 74.38, 73.99 -109.66, 0.57 283.46, 101.61 -63.98, -27.2 in-in in 8.2752 Saltbr-in 2.8167 HRD-in -64.65, -55.05 74.86, -6.55 in-in-out SNCiio in-out ActLoopNT-in 2.8643 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.92, 125.5 APE9-dihe-na -77.61, -163.62 APE8-dihe-in -56.98, 127.76 APE8-rot-in 299.91 APE67-dihe-in -61.39, -22.49 -53.63, -41.57 APE12-dist-in 9.2019 APE11-dist-out 5.4661 APE10-dist-out 10.4073 APE9-dist-in 4.0483 None SEP241 SEP241 XRAY 1.7 0.174 0.202 A 310.0 278.0 10 30 20 10 [[82, 342]] 1.0 1uu3 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 1UU7A O15530 73 359 556.0 BI2:1364 Type1 Inactive DFGin 6.5571 14.7415 BLAminus -136.5, -171.94 74.29, 73.79 -109.8, -2.64 287.37, 96.13 -53.85, -39.14 in-in in 8.463 Saltbr-in 2.8801 HRD-in -68.07, -51.28 73.99, -8.84 in-in-out SNCiio in-out ActLoopNT-in 2.8332 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.82, 121.67 APE9-dihe-na -67.64, -173.23 APE8-dihe-in -49.06, 125.05 APE8-rot-in 301.64 APE67-dihe-in -67.12, -19.88 -49.14, -41.33 APE12-dist-in 8.9136 APE11-dist-out 5.317 APE10-dist-out 10.2667 APE9-dist-in 3.9105 None SEP241 SEP241 XRAY 1.9 0.235 0.279 A 310.0 282.0 5 30 25 5 [[82, 342]] 1.0 1uu7 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 1UU8A O15530 72 358 556.0 BI1:1368 Type1 Inactive DFGin 6.6469 14.4714 BLAminus -136.37, -165.37 63.01, 71.98 -101.9, 2.54 288.65, 101.81 -58.08, -33.97 in-in in 8.8152 Saltbr-in 2.7275 HRD-in -71.97, -53.07 75.47, 11.05 in-in-out SNCiio in-out ActLoopNT-in 2.8428 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -142.67, 117.85 APE9-dihe-na -65.71, -160.29 APE8-dihe-in -63.31, 129.15 APE8-rot-in 297.13 APE67-dihe-in -68.38, -3.88 -40.88, -48.91 APE12-dist-in 9.2375 APE11-dist-out 5.6529 APE10-dist-out 10.0877 APE9-dist-in 3.759 None SEP241 SEP241 XRAY 2.5 0.176 0.258 A 310.0 279.0 8 30 22 8 [[82, 342]] 1.0 1uu8 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3NAYA O15530 76 362 556.0 MP6:1 Type1 Inactive DFGin 6.7641 14.6579 BLAminus -146.79, -173.04 72.2, 70.67 -103.69, 5.05 296.95, 109.64 -60.79, -27.91 in-in in 8.5567 Saltbr-in 2.5649 HRD-in -62.07, -50.65 74.17, -9.68 in-in-out SNCiio in-out ActLoopNT-in 2.74 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.84, 118.23 APE9-dihe-na -69.99, -167.96 APE8-dihe-in -54.98, 129.37 APE8-rot-in 302.57 APE67-dihe-in -65.83, -27.98 -54.2, -37.6 APE12-dist-in 8.6002 APE11-dist-out 5.6186 APE10-dist-out 10.5309 APE9-dist-in 3.8392 None SEP241 SEP241 XRAY 2.6 0.211 0.274 A 311.0 279.0 8 30 22 8 [[82, 342]] 1.0 3nay AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3NAYB O15530 76 362 556.0 MP6:2 Type1 Inactive DFGin 6.8794 14.3665 BLAminus -131.67, -178.35 72.0, 77.09 -107.77, 17.41 299.66, 102.49 -69.46, -28.42 in-in in 8.3299 Saltbr-in 2.8238 HRD-in -70.5, -49.88 76.39, -13.79 in-in-out SNCiio in-out ActLoopNT-in 2.8417 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 114.84, 100.21 APE9-dihe-na -68.09, -163.03 APE8-dihe-in -59.66, 125.08 APE8-rot-in 300.78 APE67-dihe-in -68.69, -23.52 -42.99, -40.54 APE12-dist-in 8.7294 APE11-dist-out 5.8365 APE10-dist-out 10.6017 APE9-dist-in 3.8844 None SEP241 SEP241 XRAY 2.6 0.211 0.274 B 311.0 279.0 8 30 22 8 [[82, 342]] 1.0 3nay AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3RWPA O15530 73 359 556.0 ABQ:360 Type1 Inactive DFGin 6.6301 14.6122 BLAminus -138.06, -171.84 73.21, 68.9 -101.84, 0.77 284.24, 99.91 -67.12, -24.97 in-in in 8.4872 Saltbr-in 2.668 HRD-in -72.19, -48.95 75.52, -7.14 in-in-out SNCiio in-out ActLoopNT-in 2.8439 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.4, 122.62 APE9-dihe-na -64.5, -165.33 APE8-dihe-in -62.97, 132.8 APE8-rot-in 302.69 APE67-dihe-in -57.73, -26.43 -57.73, -39.86 APE12-dist-in 9.571 APE11-dist-out 5.748 APE10-dist-out 10.613 APE9-dist-in 4.2017 None SEP241 SEP241 XRAY 1.92 0.174 0.213 A 311.0 278.0 9 30 21 9 [[82, 342]] 1.0 3rwp AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3RWQA O15530 72 359 556.0 3RW:1 Type1 Inactive DFGin 6.5891 14.463 BLAminus -143.65, -172.61 68.52, 70.31 -102.07, 3.38 289.03, 95.5 -56.64, -39.2 in-in in 8.5646 Saltbr-in 2.7282 HRD-in -70.4, -52.28 81.8, -9.17 in-in-out SNCiio in-out ActLoopNT-in 3.02 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.88, 122.18 APE9-dihe-na -69.74, -149.03 APE8-dihe-in -75.72, 125.93 APE8-rot-in 318.02 APE67-dihe-in -73.55, -21.89 -37.75, -44.68 APE12-dist-in 9.2067 APE11-dist-out 5.8786 APE10-dist-out 10.5237 APE9-dist-in 4.0165 None SEP241 SEP241 XRAY 2.55 0.196 0.256 A 311.0 284.0 4 30 26 4 [[82, 342]] 1.0 3rwq AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3H9OA O15530 75 359 556.0 9BD:1 Type1 Inactive DFGin 6.5678 14.261 BLAminus -131.94, -168.71 66.62, 79.57 -104.6, 18.2 283.3, 82.81 -72.27, -11.03 in-in in 8.8763 Saltbr-in 2.5436 HRD-in -78.26, -52.42 80.3, -1.11 in-in-out SNCiio in-out ActLoopNT-in 2.8097 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 77.5, 119.89 APE9-dihe-na -89.12, -112.65 APE8-dihe-in -101.23, 134.92 APE8-rot-in 301.13 APE67-dihe-in -62.27, -18.27 -50.83, -50.03 APE12-dist-in 9.6432 APE11-dist-out 6.2678 APE10-dist-out 10.1736 APE9-dist-in 3.934 None SEP241 SEP241 XRAY 2.3 0.211 0.256 A 311.0 276.0 9 30 21 9 [[82, 342]] 1.0 3h9o AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 2R7BA O15530 75 359 556.0 253:701 Type1 Inactive DFGin 6.1992 14.366 BLAminus -133.94, -179.49 77.82, 81.49 -108.24, 22.02 291.13, 86.98 -68.69, -10.97 in-in in 8.8662 Saltbr-in 2.5883 HRD-in -75.75, -47.44 52.14, 30.84 in-in-out SNCiio in-out ActLoopNT-in 2.7982 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 148.51, 113.35 APE9-dihe-na -77.58, -157.1 APE8-dihe-in -58.21, 135.29 APE8-rot-in 301.99 APE67-dihe-in -57.75, -20.67 -44.89, -55.44 APE12-dist-in 9.1968 APE11-dist-out 5.7727 APE10-dist-out 9.8875 APE9-dist-in 4.0959 None SEP241 SEP241 XRAY 2.7 0.225 0.25 A 312.0 275.0 10 30 20 10 [[82, 342]] 1.0 2r7b AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3IONA O15530 75 359 556.0 8H1:1 Type1 Inactive DFGin 6.3855 14.0119 BLAminus -129.57, -169.56 64.12, 80.16 -106.23, 22.91 285.85, 87.72 -68.81, -24.37 in-in in 8.9313 Saltbr-in 3.3369 HRD-in -74.01, -54.84 77.47, 1.06 in-in-out SNCiio in-out ActLoopNT-in 2.7001 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 132.89 APE9-dihe-na -88.46, -116.13 APE8-dihe-in -104.9, 134.52 APE8-rot-in 307.56 APE67-dihe-in -73.92, -18.65 -45.98, -45.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.0803 APE9-dist-in 3.6029 None None None XRAY 2.4 0.246 0.282 A 312.0 274.0 11 30 19 11 [[82, 342]] 1.0 3ion AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3IOPA O15530 75 359 556.0 8I1:1 Type1 Inactive DFGin 6.6057 14.3164 BLAminus -125.3, -165.97 58.12, 80.1 -105.24, 23.38 285.73, 86.81 -73.19, -11.32 in-in in 8.8064 Saltbr-in 2.6809 HRD-in -71.7, -52.98 78.46, -5.63 in-in-out SNCiio in-out ActLoopNT-in 2.8075 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 67.02, 113.91 APE9-dihe-na -74.5, -127.28 APE8-dihe-in -97.61, 129.5 APE8-rot-in 303.0 APE67-dihe-in -63.74, -18.61 -44.16, -50.92 APE12-dist-in 9.5697 APE11-dist-out 5.9687 APE10-dist-out 10.4647 APE9-dist-in 3.7908 None SEP241 SEP241 XRAY 2.2 0.24 0.278 A 312.0 276.0 9 30 21 9 [[82, 342]] 1.0 3iop AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3QCQA O15530 73 358 556.0 3Q0:370 Type1 Inactive DFGin 6.286 13.9428 BLAminus -130.07, -172.39 67.81, 84.85 -116.19, 10.14 290.92, 91.68 -60.0, -35.96 in-in in 8.6682 Saltbr-in 2.8169 HRD-in -76.77, -43.93 72.04, -4.3 in-in-out SNCiio in-out ActLoopNT-in 2.9565 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.34, 117.15 APE9-dihe-na -68.0, -161.08 APE8-dihe-in -59.72, 132.52 APE8-rot-in 308.25 APE67-dihe-in -73.95, -13.03 -56.44, -42.24 APE12-dist-in 9.3219 APE11-dist-out 6.2157 APE10-dist-out 10.3256 APE9-dist-in 4.2085 None SEP241 SEP241 XRAY 2.501 0.181 0.251 A 312.0 277.0 9 30 21 9 [[82, 342]] 1.0 3qcq AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3QCSA O15530 73 358 556.0 3Q1:370 Type1 Inactive DFGin 6.4977 14.3423 BLAminus -129.15, -172.55 69.95, 84.25 -118.54, 4.81 283.02, 93.04 -59.77, -28.42 in-in in 8.591 Saltbr-in 2.8075 HRD-in -71.62, -47.65 74.15, -7.51 in-in-out SNCiio in-out ActLoopNT-in 2.8349 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -125.7, 120.85 APE9-dihe-na -72.97, -164.1 APE8-dihe-in -54.02, 130.58 APE8-rot-in 312.22 APE67-dihe-in -61.81, -24.07 -54.55, -47.19 APE12-dist-in 9.2353 APE11-dist-out 6.3341 APE10-dist-out 10.5363 APE9-dist-in 4.4067 None SEP241 SEP241 XRAY 2.487 0.182 0.251 A 312.0 277.0 9 30 21 9 [[82, 342]] 1.0 3qcs AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3PWYA O15530 71 359 556.0 SYP:1 Type1 Inactive DFGin 6.477 14.4835 BLAminus -124.65, -178.35 67.96, 96.3 -130.58, 11.45 300.55, 97.42 -64.93, -31.03 in-in in 8.587 Saltbr-in 2.6927 HRD-in -58.86, -48.53 68.39, -3.99 in-in-out SNCiio in-out ActLoopNT-in 2.761 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.65, 129.21 APE9-dihe-na -78.78, -151.6 APE8-dihe-in -77.12, 126.15 APE8-rot-in 307.61 APE67-dihe-in -78.87, -27.54 -44.08, -37.51 APE12-dist-in 10.3267 APE11-dist-out 5.848 APE10-dist-out 10.5798 APE9-dist-in 3.8548 E166C,C260S None None XRAY 3.5 0.226 0.276 A 311.0 281.0 8 30 22 8 [[82, 342]] 1.0 3pwy AGC_PDPK1_HUMAN AGC 9.5e-84 286.4 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 2XCKA O15530 76 359 556.0 MH4:1360 Type1 Inactive DFGin 6.7771 14.7278 BLAminus -138.18, -175.27 71.05, 75.56 -104.69, 7.11 286.41, 101.4 -56.07, -44.06 in-in in 8.7216 Saltbr-in 2.7225 HRD-in -74.69, -54.88 79.61, -3.05 in-in-out SNCiio in-out ActLoopNT-in 2.891 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -108.24, 134.08 APE9-dihe-na -87.44, -159.07 APE8-dihe-in -56.55, 126.47 APE8-rot-in 304.89 APE67-dihe-in -62.34, -18.12 -47.8, -48.47 APE12-dist-in 9.3328 APE11-dist-out 5.5135 APE10-dist-out 10.4019 APE9-dist-in 3.8752 None SEP241 SEP241 XRAY 2.3 0.195 0.24 A 309.0 276.0 8 30 22 8 [[82, 342]] 1.0 2xck AGC_PDPK1_HUMAN AGC 1.8e-83 285.5 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3QCXA O15530 73 358 556.0 3Q2:370 Type1.5_Back Inactive DFGin 6.5656 14.4479 BLAminus -128.85, -170.97 71.83, 79.3 -115.33, 7.3 284.13, 92.7 -60.73, -28.9 in-in in 8.4024 Saltbr-in 2.7064 HRD-in -68.18, -50.11 76.96, -14.11 in-in-out SNCiio in-out ActLoopNT-in 2.8031 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -135.89, 122.06 APE9-dihe-na -67.11, -167.83 APE8-dihe-in -62.01, 135.81 APE8-rot-in 308.12 APE67-dihe-in -61.25, -24.88 -55.14, -44.7 APE12-dist-in 9.4652 APE11-dist-out 6.3732 APE10-dist-out 10.3227 APE9-dist-in 4.269 None SEP241 SEP241 XRAY 2.3 0.184 0.225 A 312.0 277.0 9 30 21 9 [[82, 342]] 1.0 3qcx AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3QCYA O15530 73 358 556.0 3Q3:371 Type1.5_Front Inactive DFGin 6.3885 14.5918 BLAminus -136.93, -173.16 70.99, 75.14 -110.32, 14.26 284.13, 86.28 -62.73, -28.34 in-in in 8.4189 Saltbr-in 2.559 HRD-in -71.32, -53.51 82.01, -8.81 in-in-out SNCiio in-out ActLoopNT-in 2.825 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 125.83 APE9-dihe-na -76.07, -148.77 APE8-dihe-in -79.07, 127.11 APE8-rot-in 312.38 APE67-dihe-in -58.65, -24.48 -40.2, -55.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.317 APE9-dist-in 4.4989 None SEP241 SEP241 XRAY 2.2 0.181 0.212 A 312.0 275.0 11 30 19 11 [[82, 342]] 1.0 3qcy AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3QD3A O15530 71 358 556.0 3Q5:360 Type1.5_Front Inactive DFGin 6.6397 14.7756 BLAminus -136.15, -173.35 75.08, 78.84 -114.86, 7.79 284.21, 92.48 -60.8, -30.07 in-in in 8.4699 Saltbr-in 2.5474 HRD-in -69.84, -52.9 76.92, -8.58 in-in-out SNCiio in-out ActLoopNT-in 2.8112 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -114.87, 124.76 APE9-dihe-na -70.78, -165.19 APE8-dihe-in -61.65, 129.32 APE8-rot-in 306.27 APE67-dihe-in -62.1, -22.78 -46.86, -49.49 APE12-dist-in 8.9916 APE11-dist-out 5.7339 APE10-dist-out 10.4141 APE9-dist-in 4.0376 None SEP241 SEP241 XRAY 2.0 0.185 0.211 A 312.0 279.0 9 30 21 9 [[82, 342]] 1.0 3qd3 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3NAXA O15530 76 360 556.0 MP7:363 Type2 Inactive DFGout 15.1303 9.5196 BBAminus -103.03, 154.8 -117.91, 140.31 -115.35, 34.44 271.6, 90.85 93.28, 8.79 out-out out 17.0845 Saltbr-out 10.2575 HRD-in -72.23, -50.17 78.89, -10.91 out-in-none SNCoin in-none ActLoopNT-in 2.8524 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.19, -19.08 999.0, -56.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.166 0.195 A 311.0 278.0 7 30 23 7 [[82, 342]] 1.0 3nax AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3QC4A O15530 76 359 556.0 MP7:60001 Type2 Inactive DFGout 15.1445 8.4181 BBAminus -116.84, 146.54 -96.89, 143.53 -123.04, 29.2 249.8, 111.12 113.47, -5.45 out-out out 19.868 Saltbr-out 17.8176 HRD-in -79.45, -51.8 76.86, -8.13 out-in-in SNCoii in-in ActLoopNT-in 3.035 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.28, 161.52 APE9-dihe-na 127.76, -165.1 APE8-dihe-in -132.92, 137.19 APE8-rot-in 293.31 APE67-dihe-in -63.51, -29.78 -55.77, -40.56 APE12-dist-in 7.6463 APE11-dist-in 10.8912 APE10-dist-in 5.0977 APE9-dist-in 3.6028 E303A,K304A SEP241 SEP241 XRAY 1.8 0.174 0.213 A 314.0 277.0 7 30 23 7 [[82, 342]] 1.0 3qc4 AGC_PDPK1_HUMAN AGC 5.4e-84 287.2 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3QC4B O15530 51 359 556.0 MP7:60002 Type2 Inactive DFGout 15.5034 8.2994 None -106.7, 145.77 -96.8, 153.42 -131.45, 34.1 235.15, 115.54 107.65, 4.91 out-out out 18.0578 Saltbr-out 15.1697 HRD-in -74.82, -53.49 77.73, -9.15 out-in-in SNCoii in-in ActLoopNT-in 2.9345 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.95, 158.08 APE9-dihe-na 130.3, -155.43 APE8-dihe-in -143.11, 135.86 APE8-rot-in 293.55 APE67-dihe-in -66.08, -20.71 -55.87, -43.65 APE12-dist-in 7.6714 APE11-dist-in 10.9464 APE10-dist-in 5.0678 APE9-dist-in 3.5388 E303A,K304A SEP241 SEP241 XRAY 1.8 0.174 0.213 B 314.0 274.0 15 30 23 7 [[82, 342]] 1.0 3qc4 AGC_PDPK1_HUMAN AGC 5.4e-84 287.2 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 4CT1A O15530 76 359 556.0 ATP:500,31S:600 ATPlike,Allosteric None DFGin 6.6022 14.9785 BLAminus -141.71, -172.51 72.43, 72.08 -107.06, 8.07 284.9, 97.13 -62.67, -20.12 in-none in 8.1463 Saltbr-none 999.0 HRD-in -74.62, -54.47 79.43, -8.97 none-in-in SNCnii in-in ActLoopNT-in 2.9992 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.29, 160.89 APE9-dihe-na 137.85, -171.95 APE8-dihe-in -126.26, 129.35 APE8-rot-in 296.2 APE67-dihe-in -61.08, -24.26 -47.64, -46.5 APE12-dist-in 7.3566 APE11-dist-in 10.4885 APE10-dist-in 5.0182 APE9-dist-in 3.4798 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A SEP241 SEP241 XRAY 1.85 0.172 0.215 A 311.0 284.0 0 30 30 0 [[82, 342]] 1.0 4ct1 AGC_PDPK1_HUMAN AGC 9.5e-84 286.4 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3QD0A O15530 73 358 556.0 3Q4:370 Type1.5_Front None DFGin 6.5836 14.7913 BLAminus -135.89, -173.14 73.55, 73.02 -106.35, 12.12 281.49, 88.39 -54.84, -35.9 in-in in 8.5258 Saltbr-in 2.5731 HRD-in -72.98, -50.98 74.13, -9.69 in-in-none SNCiin in-none ActLoopNT-in 2.8508 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.13 APE8-dihe-in -74.4, 123.75 APE8-rot-in 309.46 APE67-dihe-in -59.36, -28.41 -43.01, -50.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.7652 None SEP241 SEP241 XRAY 1.99 0.191 0.231 A 312.0 274.0 12 30 18 12 [[82, 342]] 1.0 3qd0 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 3QD4A O15530 71 358 556.0 3Q6:360 Type1.5_Front None DFGin 6.4034 14.6264 BLAminus -137.72, -173.39 72.99, 75.84 -110.69, 10.4 285.12, 91.81 -64.41, -29.28 in-in in 8.5579 Saltbr-in 2.7898 HRD-in -69.09, -51.69 76.33, -7.4 in-in-none SNCiin in-none ActLoopNT-in 2.9076 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -153.49 APE8-dihe-in -83.46, 122.24 APE8-rot-in 298.92 APE67-dihe-in -62.96, -22.94 -34.73, -56.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.1203 None SEP241 SEP241 XRAY 2.3 0.199 0.244 A 312.0 276.0 12 30 18 12 [[82, 342]] 1.0 3qd4 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1

AGC_PDPK1 (3-phosphoinositide-dependent protein kinase 1)

Total number of chains: 82
Active chains: 28
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 79 96.3% AF-O15530-K1A
DFGout BBAminus 2 2.4% 3NAXA
DFGout None 1 1.2% 3QC4B

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
PDPK1 PDPK1_HUMAN 2BIYA O15530 72 359 556.0 ATP:1373 ATPlike Active DFGin 6.6186 15.0949 BLAminus -141.33, -175.84 82.91, 67.67 -104.99, 1.58 283.05, 104.18 -61.63, -33.06 in-in in 8.6731 Saltbr-in 2.5745 HRD-in -63.52, -52.73 78.44, -11.09 in-in-in SNCiii in-in ActLoopNT-in 2.8201 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.22, 130.12 APE9-dihe-na 106.71, 171.13 APE8-dihe-in -96.94, 126.07 APE8-rot-in 299.07 APE67-dihe-in -62.15, -19.51 -52.23, -44.36 APE12-dist-in 12.8679 APE11-dist-in 12.8691 APE10-dist-in 7.2677 APE9-dist-in 4.7446 S241A None None XRAY 1.95 0.186 0.23 A 310.0 288.0 0 30 30 0 [[82, 342]] 1.0 2biy Homo sapiens AGC_PDPK1_HUMAN AGC 1.8e-84 288.8 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3HRCA O15530 76 359 556.0 ATP:1373 ATPlike Active DFGin 6.4861 14.8331 BLAminus -136.91, -178.17 71.81, 74.55 -104.54, 6.98 286.89, 102.51 -65.47, -24.41 in-in in 8.4211 Saltbr-in 3.1591 HRD-in -77.24, -54.93 76.93, -11.42 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.25, 162.0 APE9-dihe-na 130.63, -171.63 APE8-dihe-in -125.01, 129.68 APE8-rot-in 292.48 APE67-dihe-in -58.92, -25.29 -45.32, -48.7 APE12-dist-in 7.4085 APE11-dist-in 10.582 APE10-dist-in 4.9259 APE9-dist-in 3.4793 Y288G,Q292A SEP241 SEP241 XRAY 1.91 0.182 0.207 A 311.0 280.0 4 30 26 4 [[82, 342]] 1.0 3hrc Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 4RRVA O15530 76 359 556.0 ATP:60401 ATPlike Active DFGin 6.5481 14.9984 BLAminus -136.55, -175.99 74.63, 72.8 -106.52, 5.78 286.61, 100.18 -68.12, -17.88 in-in in 8.5198 Saltbr-in 2.956 HRD-in -71.77, -54.29 78.75, -11.73 in-in-in SNCiii in-in ActLoopNT-in 2.9375 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.13, 162.83 APE9-dihe-na 132.08, -169.67 APE8-dihe-in -127.24, 132.02 APE8-rot-in 298.33 APE67-dihe-in -59.21, -24.3 -51.83, -46.04 APE12-dist-in 7.2806 APE11-dist-in 10.5025 APE10-dist-in 4.943 APE9-dist-in 3.5694 Y288G,Q292A SEP241 SEP241 XRAY 1.412 0.135 0.163 A 311.0 284.0 0 30 30 0 [[82, 342]] 1.0 4rrv Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 5ACKA O15530 73 359 556.0 ATP:500 ATPlike Active DFGin 6.6153 14.8606 BLAminus -135.34, 179.84 72.22, 79.01 -106.01, 4.14 287.93, 97.64 -67.02, -18.73 in-in in 8.4184 Saltbr-in 2.5825 HRD-in -74.68, -53.67 78.01, -12.73 in-in-in SNCiii in-in ActLoopNT-in 2.9064 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.4, 162.51 APE9-dihe-na 136.44, -168.07 APE8-dihe-in -132.35, 133.52 APE8-rot-in 296.36 APE67-dihe-in -62.96, -23.95 -54.34, -43.19 APE12-dist-in 7.3257 APE11-dist-in 10.5222 APE10-dist-in 4.9779 APE9-dist-in 3.5575 Y288G,Q292A SEP241 SEP241 XRAY 1.24 0.143 0.166 A 311.0 287.0 0 30 30 0 [[82, 342]] 1.0 5ack Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 5LVPA O15530 75 359 556.0 ATP:500 ATPlike Active DFGin 6.3028 14.9979 BLAminus -144.92, -168.82 66.06, 77.78 -108.23, 11.17 281.99, 93.22 -63.04, -32.41 in-in in 9.539 Saltbr-in 3.1581 HRD-in -77.47, -51.83 79.92, -12.48 in-in-in SNCiii in-in ActLoopNT-in 2.8481 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.64, 166.02 APE9-dihe-na 141.61, 177.5 APE8-dihe-in -123.02, 134.29 APE8-rot-in 296.02 APE67-dihe-in -68.65, -16.53 -46.89, -50.92 APE12-dist-in 7.9068 APE11-dist-in 10.6706 APE10-dist-in 5.166 APE9-dist-in 3.7049 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 A 311.0 276.0 9 30 21 9 [[82, 342]] 1.0 5lvp Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 5LVPB O15530 74 359 556.0 ATP:401 ATPlike Active DFGin 6.3283 14.5498 BLAminus -137.23, -179.71 80.14, 74.16 -105.47, 15.38 295.0, 84.83 -59.91, -31.47 in-in in 9.2741 Saltbr-in 3.3024 HRD-in -80.68, -44.41 73.96, -16.23 in-in-in SNCiii in-in ActLoopNT-in 2.7443 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.8, 152.43 APE9-dihe-na 134.43, -173.75 APE8-dihe-in -120.09, 128.28 APE8-rot-in 302.93 APE67-dihe-in -67.56, -25.72 -44.99, -47.55 APE12-dist-in 7.8719 APE11-dist-in 11.0112 APE10-dist-in 5.3751 APE9-dist-in 3.7868 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 B 311.0 277.0 9 30 21 9 [[82, 342]] 1.0 5lvp Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 5LVPC O15530 75 359 556.0 ATP:401 ATPlike Active DFGin 6.3906 14.6076 BLAminus -132.15, -176.81 71.98, 84.02 -116.53, 7.62 291.47, 90.46 -60.24, -24.5 in-in in 9.3044 Saltbr-in 3.0866 HRD-in -75.92, -52.06 78.45, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.8228 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.81, 168.64 APE9-dihe-na 131.92, -176.79 APE8-dihe-in -126.79, 133.21 APE8-rot-in 299.13 APE67-dihe-in -67.64, -15.8 -51.62, -50.49 APE12-dist-in 7.6523 APE11-dist-in 10.8632 APE10-dist-in 5.1235 APE9-dist-in 3.6447 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 C 311.0 276.0 9 30 21 9 [[82, 342]] 1.0 5lvp Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 5LVPD O15530 74 359 556.0 ATP:500 ATPlike Active DFGin 6.3336 14.4328 BLAminus -146.99, -174.22 74.22, 81.56 -113.84, 4.02 287.97, 93.59 -56.11, -25.73 in-in in 9.3044 Saltbr-in 3.2517 HRD-in -82.38, -50.18 78.4, -12.51 in-in-in SNCiii in-in ActLoopNT-in 2.8357 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.65, 165.17 APE9-dihe-na 129.1, -166.82 APE8-dihe-in -132.84, 129.79 APE8-rot-in 300.06 APE67-dihe-in -65.46, -17.03 -48.9, -48.47 APE12-dist-in 8.2282 APE11-dist-in 10.8909 APE10-dist-in 5.3485 APE9-dist-in 3.6459 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 D 311.0 277.0 9 30 21 9 [[82, 342]] 1.0 5lvp Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 4CT2A O15530 75 359 556.0 ATP:500 ATPlike Active DFGin 6.5509 14.8668 BLAminus -136.23, -174.98 70.54, 70.07 -102.02, 6.41 290.69, 95.78 -63.73, -21.59 in-in in 8.2523 Saltbr-in 2.6427 HRD-in -73.2, -54.84 77.37, -9.78 in-in-in SNCiii in-in ActLoopNT-in 2.9649 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.02, 163.59 APE9-dihe-na 137.39, -170.05 APE8-dihe-in -132.12, 131.72 APE8-rot-in 295.26 APE67-dihe-in -63.06, -17.27 -51.84, -45.87 APE12-dist-in 7.1628 APE11-dist-in 10.5242 APE10-dist-in 4.9787 APE9-dist-in 3.5273 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A SEP241 SEP241 XRAY 1.25 0.194 0.226 A 311.0 280.0 5 30 30 0 [[82, 342]] 1.0 4ct2 Homo sapiens AGC_PDPK1_HUMAN AGC 9.5e-84 286.4 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 5MRDA O15530 76 359 556.0 ATP:405 ATPlike Active DFGin 6.4288 14.7004 BLAminus -133.69, -177.11 74.21, 73.9 -105.88, 9.0 289.39, 99.64 -68.32, -19.62 in-in in 8.3463 Saltbr-in 2.6673 HRD-in -74.32, -53.19 77.26, -10.58 in-in-in SNCiii in-in ActLoopNT-in 2.9416 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.86, 160.68 APE9-dihe-na 136.11, -166.87 APE8-dihe-in -131.1, 132.63 APE8-rot-in 296.36 APE67-dihe-in -62.36, -23.28 -53.02, -44.84 APE12-dist-in 7.3524 APE11-dist-in 10.4975 APE10-dist-in 4.9095 APE9-dist-in 3.5424 K76S,L113V,I118V,I119N,V124I,T128Q,R131K,T148C SEP241 SEP241 XRAY 1.41 0.142 0.174 A 310.0 284.0 0 30 30 0 [[82, 342]] 1.0 5mrd Homo sapiens AGC_PDPK1_HUMAN AGC 1.7e-83 285.6 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3HRFA O15530 75 359 556.0 ATP:1373,P47:1374 ATPlike,Allosteric Active DFGin 6.5137 14.7842 BLAminus -133.77, -176.11 75.25, 77.12 -110.83, 6.58 287.55, 100.98 -63.85, -22.79 in-in in 8.3869 Saltbr-in 2.7006 HRD-in -73.67, -53.98 76.59, -10.73 in-in-in SNCiii in-in ActLoopNT-in 2.9232 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.42, 166.15 APE9-dihe-na 124.75, -165.6 APE8-dihe-in -127.97, 128.5 APE8-rot-in 295.31 APE67-dihe-in -62.28, -24.12 -44.34, -47.42 APE12-dist-in 7.3513 APE11-dist-in 10.5457 APE10-dist-in 4.8669 APE9-dist-in 3.4806 Y288G,Q292A SEP241 SEP241 XRAY 1.9 0.165 0.177 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 3hrf Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 4A06A O15530 75 359 556.0 ATP:500,A06:600 ATPlike,Allosteric Active DFGin 6.5121 14.757 BLAminus -135.73, -177.17 74.25, 74.67 -110.25, 11.82 284.97, 101.73 -68.23, -22.46 in-in in 8.3192 Saltbr-in 2.8636 HRD-in -73.73, -51.84 74.62, -10.07 in-in-in SNCiii in-in ActLoopNT-in 2.9204 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.65, 165.25 APE9-dihe-na 128.95, -173.35 APE8-dihe-in -120.15, 131.51 APE8-rot-in 299.31 APE67-dihe-in -59.46, -27.29 -45.75, -47.91 APE12-dist-in 7.336 APE11-dist-in 10.4473 APE10-dist-in 4.8734 APE9-dist-in 3.5088 Y288G,Q292A SEP241 SEP241 XRAY 2.0 0.161 0.198 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 4a06 Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 4AW0A O15530 75 359 556.0 ATP:500,MJF:600 ATPlike,Allosteric Active DFGin 6.5313 14.9926 BLAminus -134.84, 177.25 78.73, 76.19 -106.3, 8.53 283.51, 97.11 -69.63, -19.36 in-in in 8.5954 Saltbr-in 3.0091 HRD-in -83.05, -53.03 79.45, -12.94 in-in-in SNCiii in-in ActLoopNT-in 2.9336 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.69, 159.04 APE9-dihe-na 139.48, -167.8 APE8-dihe-in -131.87, 132.42 APE8-rot-in 295.45 APE67-dihe-in -61.29, -25.28 -54.74, -42.17 APE12-dist-in 7.5089 APE11-dist-in 10.6011 APE10-dist-in 5.0264 APE9-dist-in 3.5797 Y288G,Q292A SEP241 SEP241,CME260 XRAY 1.43 0.171 0.188 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 4aw0 Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 4AW1A O15530 66 359 556.0 ATP:1360,21O:1361 ATPlike,Allosteric Active DFGin 6.325 14.155 BLAminus -137.24, -178.23 68.96, 84.69 -105.37, 17.06 286.01, 86.79 -62.77, -26.7 in-in in 8.5758 Saltbr-in 2.8639 HRD-in -81.18, -54.06 78.32, -13.29 in-in-in SNCiii in-in ActLoopNT-in 2.8487 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.98, 160.2 APE9-dihe-na 130.22, -162.57 APE8-dihe-in -126.98, 128.72 APE8-rot-in 295.96 APE67-dihe-in -57.45, -24.35 -48.01, -47.7 APE12-dist-in 7.6532 APE11-dist-in 10.8523 APE10-dist-in 5.0751 APE9-dist-in 3.5856 Y288G,Q292A SEP241 SEP241 XRAY 1.68 0.165 0.186 A 311.0 287.0 5 30 25 5 [[82, 342]] 1.0 4aw1 Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 4RQKA O15530 74 359 556.0 ATP:403,R1S:404 ATPlike,Allosteric Active DFGin 6.4608 14.7857 BLAminus -139.06, -177.03 75.27, 72.83 -105.25, 7.36 287.3, 98.33 -64.7, -21.38 in-in in 8.4643 Saltbr-in 2.9412 HRD-in -73.98, -52.31 74.79, -9.31 in-in-in SNCiii in-in ActLoopNT-in 2.8799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.64, 164.69 APE9-dihe-na 126.87, -171.23 APE8-dihe-in -124.75, 130.48 APE8-rot-in 298.57 APE67-dihe-in -59.79, -23.66 -48.31, -47.88 APE12-dist-in 7.2437 APE11-dist-in 10.4657 APE10-dist-in 4.9176 APE9-dist-in 3.5437 Y288G,Q292A SEP241 SEP241 XRAY 1.55 0.133 0.167 A 311.0 286.0 0 30 30 0 [[82, 342]] 1.0 4rqk Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 4RQVA O15530 71 359 556.0 ATP:405,R2S:406 ATPlike,Allosteric Active DFGin 6.4916 14.9536 BLAminus -139.41, -174.88 74.87, 69.78 -102.0, 7.85 285.85, 94.73 -65.11, -21.56 in-in in 8.2557 Saltbr-in 2.7717 HRD-in -72.94, -52.57 74.87, -10.5 in-in-in SNCiii in-in ActLoopNT-in 2.9156 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.07, 164.19 APE9-dihe-na 130.69, -171.7 APE8-dihe-in -126.67, 130.74 APE8-rot-in 297.63 APE67-dihe-in -61.47, -23.77 -49.17, -46.26 APE12-dist-in 7.2532 APE11-dist-in 10.4876 APE10-dist-in 4.9687 APE9-dist-in 3.5133 Y288G,Q292A SEP241 SEP241 XRAY 1.502 0.133 0.166 A 311.0 289.0 0 30 30 0 [[82, 342]] 1.0 4rqv Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 5LVOA O15530 73 359 556.0 ATP:401,78W:402 ATPlike,Allosteric Active DFGin 6.581 15.0047 BLAminus -134.78, 179.9 79.12, 70.17 -103.55, 0.25 286.72, 100.66 -64.63, -19.63 in-in in 8.5884 Saltbr-in 2.6313 HRD-in -71.89, -54.41 77.65, -9.82 in-in-in SNCiii in-in ActLoopNT-in 2.9194 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.78, 162.52 APE9-dihe-na 134.75, -167.11 APE8-dihe-in -130.46, 134.12 APE8-rot-in 296.12 APE67-dihe-in -62.26, -22.94 -53.92, -45.37 APE12-dist-in 7.4502 APE11-dist-in 10.5584 APE10-dist-in 4.9836 APE9-dist-in 3.5527 Y288G,Q292A SEP241 SEP241 XRAY 1.09 0.136 0.157 A 311.0 287.0 0 30 30 0 [[82, 342]] 1.0 5lvo Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 4XX9A O15530 71 359 556.0 ATP:401,RF4:402,RF4:403 ATPlike,Allosteric,Allosteric Active DFGin 6.5134 14.9881 BLAminus -138.47, -176.21 74.83, 73.76 -104.66, 7.86 282.59, 98.49 -68.99, -20.43 in-in in 8.4422 Saltbr-in 2.9225 HRD-in -73.71, -50.51 73.32, -9.3 in-in-in SNCiii in-in ActLoopNT-in 2.8949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.41, 162.37 APE9-dihe-na 129.79, -167.49 APE8-dihe-in -129.09, 132.1 APE8-rot-in 295.95 APE67-dihe-in -59.66, -23.23 -49.94, -47.34 APE12-dist-in 7.3717 APE11-dist-in 10.5754 APE10-dist-in 4.9467 APE9-dist-in 3.5452 Y288G,Q292A SEP241 SEP241 XRAY 1.4 0.13 0.165 A 310.0 289.0 0 30 30 0 [[82, 342]] 1.0 4xx9 Homo sapiens AGC_PDPK1_HUMAN AGC 6.8e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 4A07A O15530 75 359 556.0 ATP:500,AZ7:600,AZ7:700 ATPlike,Allosteric,Allosteric Active DFGin 6.6546 14.7523 BLAminus -135.35, -178.9 76.01, 72.4 -108.94, 8.63 286.31, 98.68 -64.37, -21.88 in-in in 8.6213 Saltbr-in 2.919 HRD-in -76.19, -54.82 80.07, -12.14 in-in-in SNCiii in-in ActLoopNT-in 2.9107 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.16, 162.52 APE9-dihe-na 132.15, -164.48 APE8-dihe-in -133.89, 130.56 APE8-rot-in 295.87 APE67-dihe-in -62.13, -24.83 -47.31, -46.9 APE12-dist-in 7.3216 APE11-dist-in 10.4272 APE10-dist-in 4.9977 APE9-dist-in 3.5816 Y288G,Q292A SEP241 SEP241,CSS260 XRAY 1.85 0.161 0.2 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 4a07 Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 8DQTA O15530 70 359 556.0 U35:401,U35:402,U35:403 Allosteric,Allosteric,Allosteric Active DFGin 6.5386 15.228 BLAminus -137.99, -177.67 76.39, 75.41 -107.03, 7.63 286.75, 95.91 -68.77, -18.63 in-in in 8.5573 Saltbr-in 2.9067 HRD-in -74.31, -48.93 74.07, -13.37 in-in-in SNCiii in-in ActLoopNT-in 2.9489 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.2, 161.34 APE9-dihe-na 132.87, -165.96 APE8-dihe-in -131.33, 133.45 APE8-rot-in 295.53 APE67-dihe-in -61.71, -24.62 -51.87, -45.17 APE12-dist-in 7.2521 APE11-dist-in 10.4342 APE10-dist-in 4.9085 APE9-dist-in 3.5907 Y288G,Q292A SEP241 SEP241 XRAY 1.31 0.2 0.224 A 311.0 290.0 0 30 30 0 [[82, 342]] 1.0 8dqt Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3OTUA O15530 77 359 556.0 J30:1,BI4:360 Allosteric,Type1.5_Front Active DFGin 6.407 14.9865 BLAminus -147.19, -166.49 62.44, 61.65 -95.64, 10.19 290.91, 105.88 -63.28, -24.6 in-in in 8.3704 Saltbr-in 3.3366 HRD-in -67.23, -53.13 82.11, -16.93 in-in-in SNCiii in-in ActLoopNT-in 2.7953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.97, 157.81 APE9-dihe-na 151.4, -176.81 APE8-dihe-in -123.26, 126.19 APE8-rot-in 294.94 APE67-dihe-in -53.95, -30.51 -40.25, -53.87 APE12-dist-in 7.7118 APE11-dist-in 10.3288 APE10-dist-in 5.2437 APE9-dist-in 4.1303 T148C SEP241 SEP241 XRAY 2.101 0.197 0.24 A 316.0 277.0 6 30 25 5 [[82, 342]] 1.0 3otu Homo sapiens AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN AF-O15530-K1A O15530 74 350 556.0 No_ligand No_ligand Active DFGin 6.307 14.7525 BLAminus -134.14, -175.03 67.73, 56.76 -81.0, 7.09 290.02, 100.1 -62.73, -31.75 in-in in 8.4785 Saltbr-in 2.6917 HRD-in -71.22, -49.98 68.85, -15.49 in-in-in SNCiii in-in ActLoopNT-in 2.9019 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.76, 160.45 APE9-dihe-na 125.82, -178.56 APE8-dihe-in -110.7, 135.78 APE8-rot-in 301.58 APE67-dihe-in -71.92, -18.9 -54.44, -36.21 APE12-dist-in 7.4783 APE11-dist-in 10.7463 APE10-dist-in 5.0363 APE9-dist-in 3.4837 None None None AF2 -1.0 1.0 1.0 A 277.0 277.0 0 30 30 0 [[82, 342]] 1.0 AF-O15530-K1 Homo sapiens AGC_PDPK1_HUMAN AGC 8.4e-85 289.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN AF-O15530-K3A O15530 74 350 556.0 No_ligand No_ligand Active DFGin 6.0234 14.6473 BLAminus -139.54, -179.29 63.97, 66.91 -82.88, 11.22 294.97, 97.73 -59.7, -35.74 in-in in 8.7295 Saltbr-in 2.6551 HRD-in -73.34, -47.9 67.59, -9.95 in-in-in SNCiii in-in ActLoopNT-in 2.8048 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.66, 143.7 APE9-dihe-na 124.83, 164.09 APE8-dihe-in -82.81, 130.45 APE8-rot-in 291.03 APE67-dihe-in -71.92, -16.19 -51.02, -35.4 APE12-dist-in 8.3871 APE11-dist-in 11.0601 APE10-dist-in 5.2904 APE9-dist-in 4.3622 None None None AF2 -1.0 1.0 1.0 A 277.0 277.0 0 30 30 0 [[82, 342]] 1.0 AF-O15530-K3 Homo sapiens AGC_PDPK1_HUMAN AGC 8.4e-85 289.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3SC1A O15530 73 359 556.0 3S1:900 Type1 Active DFGin 6.4332 14.1153 BLAminus -125.85, 175.62 82.13, 80.63 -113.39, 8.45 290.85, 87.77 -53.07, -47.22 in-in in 8.7083 Saltbr-in 3.2163 HRD-in -72.93, -48.81 80.48, -8.67 in-in-in SNCiii in-in ActLoopNT-in 2.8508 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.12, -172.48 APE9-dihe-na 115.93, 147.74 APE8-dihe-in -93.61, 137.68 APE8-rot-in 299.7 APE67-dihe-in -55.26, -32.91 -54.79, -48.8 APE12-dist-in 8.7388 APE11-dist-in 10.6062 APE10-dist-in 5.4107 APE9-dist-in 3.9864 None SEP241 SEP241 XRAY 2.7 0.2 0.237 A 311.0 279.0 8 30 22 8 [[82, 342]] 1.0 3sc1 Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3RCJA O15530 77 358 556.0 3RC:0 Type1 Active DFGin 6.5504 14.3915 BLAminus -128.99, -167.62 59.76, 67.13 -93.27, 12.1 286.78, 86.8 -60.54, -37.27 in-in in 8.539 Saltbr-in 2.7862 HRD-in -65.85, -49.34 77.48, -8.62 in-in-in SNCiii in-in ActLoopNT-in 2.8766 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.08, 164.56 APE9-dihe-na 127.57, -173.24 APE8-dihe-in -123.98, 130.3 APE8-rot-in 296.56 APE67-dihe-in -63.09, -20.07 -49.59, -44.96 APE12-dist-in 7.8304 APE11-dist-in 10.7456 APE10-dist-in 5.0252 APE9-dist-in 3.6456 Y288G,Q292A SEP241 SEP241 XRAY 1.7 0.217 0.198 A 311.0 282.0 0 30 30 0 [[82, 342]] 1.0 3rcj Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 5LVLA O15530 74 359 556.0 537:401 Type1 Active DFGin 6.5959 14.602 BLAminus -130.64, -179.01 78.07, 78.29 -107.64, 5.9 287.24, 98.42 -64.3, -24.0 in-in in 8.2927 Saltbr-in 2.5582 HRD-in -74.44, -52.48 78.34, -12.89 in-in-in SNCiii in-in ActLoopNT-in 2.9059 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.91, 163.01 APE9-dihe-na 134.48, -168.83 APE8-dihe-in -131.23, 133.97 APE8-rot-in 296.05 APE67-dihe-in -61.17, -24.01 -50.83, -47.55 APE12-dist-in 7.3206 APE11-dist-in 10.4705 APE10-dist-in 4.8806 APE9-dist-in 3.5651 Y288G,Q292A SEP241 SEP241 XRAY 1.4 0.154 0.178 A 311.0 286.0 0 30 30 0 [[82, 342]] 1.0 5lvl Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 5LVMA O15530 76 359 556.0 ADE:401 Type1 Active DFGin 6.5146 14.8576 BLAminus -134.29, -178.73 78.5, 76.19 -107.92, 3.05 284.81, 100.85 -68.49, -15.39 in-in in 8.3988 Saltbr-in 2.9222 HRD-in -74.83, -53.98 76.68, -6.53 in-in-in SNCiii in-in ActLoopNT-in 2.9138 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.77, 160.72 APE9-dihe-na 136.54, -165.87 APE8-dihe-in -131.32, 134.23 APE8-rot-in 298.42 APE67-dihe-in -62.0, -21.56 -53.2, -46.03 APE12-dist-in 7.4265 APE11-dist-in 10.5567 APE10-dist-in 4.9493 APE9-dist-in 3.5336 Y288G,Q292A SEP241 SEP241 XRAY 1.26 0.135 0.155 A 311.0 284.0 0 30 30 0 [[82, 342]] 1.0 5lvm Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 5LVNA O15530 75 359 556.0 ADN:402 Type1 Active DFGin 6.4926 14.7837 BLAminus -138.56, -175.41 73.41, 75.09 -105.63, 5.44 285.54, 101.95 -63.79, -19.6 in-in in 8.4347 Saltbr-in 2.7393 HRD-in -74.59, -52.51 78.18, -12.02 in-in-in SNCiii in-in ActLoopNT-in 2.8995 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.48, 161.66 APE9-dihe-na 136.02, -164.27 APE8-dihe-in -134.21, 135.25 APE8-rot-in 295.47 APE67-dihe-in -61.9, -23.15 -53.94, -45.84 APE12-dist-in 7.4385 APE11-dist-in 10.5331 APE10-dist-in 4.8932 APE9-dist-in 3.5664 Y288G,Q292A SEP241 SEP241 XRAY 1.379 0.135 0.162 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 5lvn Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 1H1WA O15530 71 359 556.0 ATP:1373 ATPlike Inactive DFGin 6.6116 14.931 BLAminus -145.26, -169.97 71.92, 72.18 -105.82, -0.04 289.27, 102.08 -58.33, -31.92 in-in in 8.5808 Saltbr-in 2.7103 HRD-in -71.45, -48.32 74.08, -8.04 in-in-out SNCiio in-out ActLoopNT-in 2.8395 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.69, 112.94 APE9-dihe-na -63.98, -168.66 APE8-dihe-in -54.13, 124.0 APE8-rot-in 301.59 APE67-dihe-in -62.54, -19.03 -38.83, -50.46 APE12-dist-in 8.922 APE11-dist-out 5.528 APE10-dist-out 10.2978 APE9-dist-in 3.7994 None SEP241 SEP241 XRAY 2.0 0.196 0.223 A 289.0 285.0 4 30 26 4 [[82, 342]] 1.0 1h1w Homo sapiens AGC_PDPK1_HUMAN AGC 9.8e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3ORXA O15530 75 359 556.0 1F8:1 Allosteric Inactive DFGin 6.5961 14.1691 BLAminus -138.52, -175.65 62.9, 74.02 -93.7, 13.51 275.9, 89.61 -62.84, -23.94 in-in in 8.8135 Saltbr-in 2.5558 HRD-in -68.79, -51.77 77.65, -2.64 in-in-out SNCiio in-out ActLoopNT-in 2.8365 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -110.22, 106.38 APE9-dihe-na -61.01, -163.77 APE8-dihe-in -59.2, 130.87 APE8-rot-in 313.64 APE67-dihe-in -68.86, -21.58 -48.76, -40.32 APE12-dist-in 9.226 APE11-dist-out 5.7837 APE10-dist-out 10.5309 APE9-dist-in 3.9835 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 A 316.0 284.0 1 30 29 1 [[82, 342]] 1.0 3orx Homo sapiens AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3ORXB O15530 77 359 556.0 1F8:1 Allosteric Inactive DFGin 6.6597 14.1548 BLAminus -140.69, -175.67 59.43, 71.11 -92.21, 14.29 279.78, 86.28 -63.72, -16.63 in-in in 8.802 Saltbr-in 2.5641 HRD-in -68.32, -50.05 78.21, -3.88 in-in-out SNCiio in-out ActLoopNT-in 2.8222 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -111.03, 106.62 APE9-dihe-na -60.26, -162.55 APE8-dihe-in -59.71, 131.44 APE8-rot-in 313.93 APE67-dihe-in -67.3, -21.72 -51.61, -39.66 APE12-dist-in 9.2384 APE11-dist-out 5.8005 APE10-dist-out 10.5524 APE9-dist-in 3.9081 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 B 316.0 281.0 2 30 28 2 [[82, 342]] 1.0 3orx Homo sapiens AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3ORXC O15530 75 359 556.0 1F8:1 Allosteric Inactive DFGin 6.6298 14.0961 BLAminus -135.92, -176.39 63.79, 71.64 -93.36, 13.73 280.67, 86.49 -62.67, -20.94 in-in in 8.7824 Saltbr-in 2.5509 HRD-in -66.06, -52.0 76.42, -2.2 in-in-out SNCiio in-out ActLoopNT-in 2.8354 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -110.22, 106.64 APE9-dihe-na -60.77, -161.89 APE8-dihe-in -59.91, 131.8 APE8-rot-in 311.89 APE67-dihe-in -63.47, -22.82 -49.61, -43.91 APE12-dist-in 9.1653 APE11-dist-out 5.8015 APE10-dist-out 10.55 APE9-dist-in 3.9841 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 C 316.0 284.0 1 30 29 1 [[82, 342]] 1.0 3orx Homo sapiens AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3ORXD O15530 76 359 556.0 1F8:1 Allosteric Inactive DFGin 6.5711 14.146 BLAminus -134.45, -170.09 60.8, 71.91 -91.57, 12.91 278.05, 86.51 -67.5, -17.43 in-in in 8.7987 Saltbr-in 2.5834 HRD-in -66.01, -50.34 77.25, -1.95 in-in-out SNCiio in-out ActLoopNT-in 2.8418 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -110.2, 105.71 APE9-dihe-na -59.39, -160.44 APE8-dihe-in -60.94, 132.03 APE8-rot-in 313.43 APE67-dihe-in -67.95, -22.9 -52.31, -39.76 APE12-dist-in 9.2273 APE11-dist-out 5.7904 APE10-dist-out 10.5469 APE9-dist-in 3.9121 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 D 316.0 283.0 1 30 29 1 [[82, 342]] 1.0 3orx Homo sapiens AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3ORXE O15530 76 359 556.0 1F8:1 Allosteric Inactive DFGin 6.3816 14.9206 BLAminus -125.38, -158.75 61.49, 56.01 -85.03, 10.36 279.31, 82.03 -55.13, -32.27 in-in in 9.2368 Saltbr-in 3.2715 HRD-in -67.18, -49.37 73.61, -2.74 in-in-out SNCiio in-out ActLoopNT-in 2.9678 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -112.75, 120.85 APE9-dihe-na -80.18, -170.48 APE8-dihe-in -52.91, 130.32 APE8-rot-in 309.26 APE67-dihe-in -61.57, -27.92 -56.84, -38.07 APE12-dist-none 999.0 APE11-dist-out 5.4882 APE10-dist-out 10.2693 APE9-dist-in 4.4822 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 E 316.0 274.0 10 30 20 10 [[82, 342]] 1.0 3orx Homo sapiens AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3ORXF O15530 75 359 556.0 1F8:1 Allosteric Inactive DFGin 6.3677 14.9155 BLAminus -124.96, -165.04 64.25, 56.63 -90.23, 13.81 273.61, 91.31 -58.82, -32.5 in-none in 9.2317 Saltbr-none 999.0 HRD-in -66.95, -49.19 76.54, -9.89 none-in-out SNCnio in-out ActLoopNT-in 2.9816 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -112.23, 117.01 APE9-dihe-na -74.75, -174.06 APE8-dihe-in -40.45, 117.92 APE8-rot-in 309.94 APE67-dihe-in -62.78, -29.13 -41.21, -44.42 APE12-dist-in 8.1177 APE11-dist-out 5.4885 APE10-dist-out 10.2748 APE9-dist-in 4.4634 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 F 316.0 275.0 10 30 20 10 [[82, 342]] 1.0 3orx Homo sapiens AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3ORXG O15530 75 359 556.0 1F8:1 Allosteric Inactive DFGin 6.4182 15.1625 BLAminus -124.35, -160.11 59.71, 58.4 -85.01, 8.33 270.63, 86.47 -58.24, -35.05 in-in in 9.2322 Saltbr-in 3.2566 HRD-in -66.57, -49.64 76.01, -6.1 in-in-out SNCiio in-out ActLoopNT-in 3.0259 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.59, 119.71 APE9-dihe-na -80.06, -167.69 APE8-dihe-in -52.92, 132.86 APE8-rot-in 313.01 APE67-dihe-in -62.53, -35.87 -56.69, -38.23 APE12-dist-in 8.4931 APE11-dist-out 5.4816 APE10-dist-out 10.2289 APE9-dist-in 4.3614 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 G 316.0 275.0 10 30 20 10 [[82, 342]] 1.0 3orx Homo sapiens AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3ORXH O15530 75 359 556.0 1F8:1 Allosteric Inactive DFGin 6.4702 14.8365 BLAminus -123.34, -162.32 62.45, 60.25 -89.76, 14.7 283.48, 85.4 -55.85, -32.26 in-in in 9.2345 Saltbr-in 3.2833 HRD-in -67.42, -48.8 75.62, -9.07 in-in-out SNCiio in-out ActLoopNT-in 2.9802 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -112.9, 122.93 APE9-dihe-na -81.65, -170.32 APE8-dihe-in -53.77, 133.41 APE8-rot-in 303.61 APE67-dihe-in -61.23, -30.63 -57.13, -39.02 APE12-dist-in 8.3784 APE11-dist-out 5.4961 APE10-dist-out 10.1982 APE9-dist-in 4.4177 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 H 316.0 275.0 10 30 20 10 [[82, 342]] 1.0 3orx Homo sapiens AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3ORZA O15530 74 359 556.0 2A2:1,BI4:360 Allosteric,Type1 Inactive DFGin 6.6225 14.6052 BLAminus -134.96, -167.36 70.2, 66.13 -101.26, 0.99 293.7, 88.7 -61.05, -29.24 in-in in 8.2152 Saltbr-in 2.8103 HRD-in -65.12, -49.46 75.7, -10.07 in-in-out SNCiio in-out ActLoopNT-in 2.8327 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -134.38, 111.86 APE9-dihe-na -60.27, -174.97 APE8-dihe-in -55.74, 132.42 APE8-rot-in 303.15 APE67-dihe-in -56.98, -32.17 -55.27, -42.37 APE12-dist-in 11.5493 APE11-dist-out 6.544 APE10-dist-out 10.866 APE9-dist-in 4.1173 T148C SEP241 SEP241 XRAY 2.0 0.22 0.265 A 316.0 277.0 9 30 21 9 [[82, 342]] 1.0 3orz Homo sapiens AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3ORZB O15530 73 359 556.0 2A2:1,BI4:360 Allosteric,Type1 Inactive DFGin 6.6476 14.7764 BLAminus -139.38, -168.66 74.13, 69.92 -111.18, 3.04 284.6, 93.64 -63.39, -24.83 in-in in 8.2923 Saltbr-in 2.7592 HRD-in -64.66, -48.81 76.86, -10.42 in-in-out SNCiio in-out ActLoopNT-in 2.8659 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.43, 114.97 APE9-dihe-na -62.67, -167.65 APE8-dihe-in -63.67, 131.38 APE8-rot-in 299.84 APE67-dihe-in -54.64, -32.97 -56.45, -39.98 APE12-dist-in 11.638 APE11-dist-out 6.3971 APE10-dist-out 10.7873 APE9-dist-in 4.0869 T148C SEP241 SEP241 XRAY 2.0 0.22 0.265 B 316.0 279.0 8 30 22 8 [[82, 342]] 1.0 3orz Homo sapiens AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3ORZC O15530 74 359 556.0 2A2:1,BI4:360 Allosteric,Type1 Inactive DFGin 6.6668 14.6791 BLAminus -134.07, -170.51 76.79, 69.39 -110.34, 1.38 287.93, 89.81 -56.71, -30.43 in-in in 8.2245 Saltbr-in 2.8037 HRD-in -64.4, -49.76 78.61, -9.94 in-in-out SNCiio in-out ActLoopNT-in 2.8049 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -134.53, 111.0 APE9-dihe-na -58.83, -174.56 APE8-dihe-in -56.66, 132.63 APE8-rot-in 302.29 APE67-dihe-in -56.84, -32.58 -55.43, -42.03 APE12-dist-in 11.7307 APE11-dist-out 6.55 APE10-dist-out 10.875 APE9-dist-in 4.0824 T148C SEP241 SEP241 XRAY 2.0 0.22 0.265 C 316.0 277.0 9 30 21 9 [[82, 342]] 1.0 3orz Homo sapiens AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3ORZD O15530 73 359 556.0 2A2:1,BI4:360 Allosteric,Type1 Inactive DFGin 6.6487 14.7735 BLAminus -139.63, -168.42 74.39, 69.06 -110.33, 3.29 285.32, 93.06 -63.48, -24.84 in-in in 8.3101 Saltbr-in 2.754 HRD-in -64.65, -47.43 73.97, -9.52 in-in-out SNCiio in-out ActLoopNT-in 2.8768 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -126.78, 121.12 APE9-dihe-na -63.33, -166.44 APE8-dihe-in -63.66, 131.18 APE8-rot-in 301.29 APE67-dihe-in -54.43, -33.46 -55.31, -40.36 APE12-dist-in 11.5839 APE11-dist-out 6.4058 APE10-dist-out 10.8417 APE9-dist-in 4.0404 T148C SEP241 SEP241 XRAY 2.0 0.22 0.265 D 316.0 279.0 8 30 22 8 [[82, 342]] 1.0 3orz Homo sapiens AGC_PDPK1_HUMAN AGC 7.9e-85 290.0 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 1Z5MA O15530 74 359 556.0 LI8:501 Type1 Inactive DFGin 6.9657 14.6691 BLAminus -143.06, -166.04 70.1, 70.4 -106.54, 10.63 285.55, 95.37 -57.95, -38.82 in-in in 8.979 Saltbr-in 2.8616 HRD-in -60.53, -42.76 63.99, 3.89 in-in-out SNCiio in-out ActLoopNT-in 2.6826 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -142.8, 123.87 APE9-dihe-na -69.98, -168.75 APE8-dihe-in -47.59, 126.16 APE8-rot-in 298.44 APE67-dihe-in -75.58, -18.39 -37.0, -46.81 APE12-dist-in 8.5442 APE11-dist-out 6.2855 APE10-dist-out 10.4569 APE9-dist-in 4.0502 None SEP241 SEP241 XRAY 2.17 0.232 0.269 A 286.0 276.0 10 30 20 10 [[82, 342]] 1.0 1z5m Homo sapiens AGC_PDPK1_HUMAN AGC 9.4e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 2PE0A O15530 74 359 556.0 39Z:501 Type1 Inactive DFGin 6.4474 14.3844 BLAminus -129.98, -179.46 78.75, 74.81 -106.99, 5.13 286.59, 90.93 -55.7, -29.7 in-in in 8.7227 Saltbr-in 2.7831 HRD-in -72.01, -55.71 78.26, -0.88 in-in-out SNCiio in-out ActLoopNT-in 2.8174 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.01, 133.16 APE9-dihe-na -80.12, -143.18 APE8-dihe-in -90.02, 137.86 APE8-rot-in 307.83 APE67-dihe-in -64.54, -15.21 -51.36, -49.75 APE12-dist-in 9.1401 APE11-dist-out 5.5127 APE10-dist-out 10.1028 APE9-dist-in 3.7888 None SEP241 SEP241 XRAY 2.35 0.202 0.24 A 286.0 276.0 10 30 20 10 [[82, 342]] 1.0 2pe0 Homo sapiens AGC_PDPK1_HUMAN AGC 9.4e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 2PE1A O15530 74 359 556.0 517:501 Type1 Inactive DFGin 6.6447 14.6824 BLAminus -139.4, -175.86 73.15, 71.4 -105.21, 7.65 286.89, 93.63 -52.89, -40.97 in-in in 8.8829 Saltbr-in 2.5948 HRD-in -69.74, -56.95 81.13, 2.35 in-in-out SNCiio in-out ActLoopNT-in 2.8564 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -114.84, 143.11 APE9-dihe-na -79.47, -134.7 APE8-dihe-in -90.68, 136.03 APE8-rot-in 300.98 APE67-dihe-in -68.92, -11.38 -43.74, -52.34 APE12-dist-in 9.1167 APE11-dist-out 5.7014 APE10-dist-out 10.3798 APE9-dist-in 3.6055 None SEP241 SEP241 XRAY 2.14 0.224 0.282 A 286.0 276.0 10 30 20 10 [[82, 342]] 1.0 2pe1 Homo sapiens AGC_PDPK1_HUMAN AGC 9.4e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 2PE2A O15530 74 359 556.0 464:501 Type1 Inactive DFGin 6.5908 14.4155 BLAminus -135.75, -175.91 78.63, 72.01 -109.62, 0.43 287.28, 93.19 -54.2, -35.84 in-in in 8.5622 Saltbr-in 2.5509 HRD-in -75.76, -49.83 75.8, -8.69 in-in-out SNCiio in-out ActLoopNT-in 2.7244 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.61, 128.36 APE9-dihe-na -70.67, -166.57 APE8-dihe-in -59.34, 134.44 APE8-rot-in 302.45 APE67-dihe-in -67.69, -11.47 -51.51, -47.62 APE12-dist-in 8.9817 APE11-dist-out 5.5266 APE10-dist-out 10.3125 APE9-dist-in 3.7381 None SEP241 SEP241 XRAY 2.13 0.189 0.215 A 286.0 276.0 10 30 20 10 [[82, 342]] 1.0 2pe2 Homo sapiens AGC_PDPK1_HUMAN AGC 9.4e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3NUSA O15530 73 358 556.0 JNZ:374 Type1 Inactive DFGin 6.6661 14.0143 BLAminus -134.94, -176.79 67.79, 79.24 -106.97, 14.51 293.69, 91.17 -56.65, -43.75 in-in in 8.6145 Saltbr-in 3.1048 HRD-in -75.65, -54.6 82.78, -6.2 in-in-out SNCiio in-out ActLoopNT-in 2.8741 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -129.47, 126.95 APE9-dihe-na -67.17, -145.64 APE8-dihe-in -85.86, 130.62 APE8-rot-in 299.93 APE67-dihe-in -70.26, -18.43 -47.43, -45.34 APE12-dist-in 9.4758 APE11-dist-out 6.257 APE10-dist-out 10.2994 APE9-dist-in 4.0295 None SEP241 SEP241 XRAY 2.75 0.177 0.236 A 286.0 277.0 9 30 21 9 [[82, 342]] 1.0 3nus Homo sapiens AGC_PDPK1_HUMAN AGC 9.4e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3NUUA O15530 73 358 556.0 JOZ:361 Type1 Inactive DFGin 6.8153 14.418 BLAminus -135.1, 176.45 77.67, 76.35 -106.62, 4.54 289.58, 95.96 -54.87, -35.17 in-in in 8.6632 Saltbr-in 2.6457 HRD-in -75.97, -55.36 84.01, -8.4 in-in-out SNCiio in-out ActLoopNT-in 2.8245 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -123.64, 126.08 APE9-dihe-na -69.19, -150.37 APE8-dihe-in -79.82, 127.26 APE8-rot-in 298.22 APE67-dihe-in -66.17, -14.72 -39.18, -51.46 APE12-dist-in 8.929 APE11-dist-out 5.8492 APE10-dist-out 10.298 APE9-dist-in 3.9915 None SEP241 SEP241 XRAY 1.98 0.189 0.239 A 286.0 277.0 9 30 21 9 [[82, 342]] 1.0 3nuu Homo sapiens AGC_PDPK1_HUMAN AGC 9.4e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3NUYA O15530 73 358 556.0 JPZ:370 Type1 Inactive DFGin 6.7298 14.5499 BLAminus -136.81, -175.62 72.08, 77.54 -106.37, 8.07 285.95, 95.42 -50.93, -42.82 in-in in 8.7638 Saltbr-in 2.731 HRD-in -78.09, -53.76 79.66, -9.09 in-in-out SNCiio in-out ActLoopNT-in 2.8966 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.52, 118.04 APE9-dihe-na -67.36, -159.8 APE8-dihe-in -67.79, 132.38 APE8-rot-in 304.86 APE67-dihe-in -62.4, -17.72 -54.87, -44.81 APE12-dist-in 9.4109 APE11-dist-out 5.8201 APE10-dist-out 10.2784 APE9-dist-in 3.9709 None SEP241 SEP241 XRAY 2.1 0.187 0.225 A 286.0 277.0 9 30 21 9 [[82, 342]] 1.0 3nuy Homo sapiens AGC_PDPK1_HUMAN AGC 9.4e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 1UU9A O15530 72 357 556.0 BI3:1370 Type1 Inactive DFGin 6.6788 14.783 BLAminus -137.61, -169.2 68.82, 72.55 -103.82, -0.34 285.88, 98.86 -59.49, -32.23 in-in in 8.3257 Saltbr-in 2.6975 HRD-in -73.71, -52.28 77.02, -6.6 in-in-out SNCiio in-out ActLoopNT-in 2.8778 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.15, 123.88 APE9-dihe-na -73.46, -162.02 APE8-dihe-in -55.23, 126.59 APE8-rot-in 305.35 APE67-dihe-in -59.52, -20.56 -41.52, -52.97 APE12-dist-in 9.3386 APE11-dist-out 5.5023 APE10-dist-out 10.2727 APE9-dist-in 3.7767 None SEP241 SEP241 XRAY 1.95 0.176 0.224 A 286.0 277.0 9 30 21 9 [[82, 342]] 1.0 1uu9 Homo sapiens AGC_PDPK1_HUMAN AGC 9.4e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 1UVRA O15530 71 359 556.0 BI8:1372 Type1 Inactive DFGin 6.5811 14.4064 BLAminus -141.7, -169.27 62.75, 72.58 -105.41, 8.55 300.9, 81.55 -59.95, -35.71 in-in in 8.5947 Saltbr-in 2.9835 HRD-in -62.43, -49.82 76.81, -6.44 in-in-out SNCiio in-out ActLoopNT-in 2.9337 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -133.17, 120.18 APE9-dihe-na -60.87, -168.42 APE8-dihe-in -53.67, 135.35 APE8-rot-in 308.99 APE67-dihe-in -63.6, -1.85 -44.81, -56.98 APE12-dist-in 7.2881 APE11-dist-out 6.6429 APE10-dist-out 10.6143 APE9-dist-in 4.0897 None SEP241 SEP241 XRAY 2.81 0.176 0.248 A 289.0 285.0 4 30 26 4 [[82, 342]] 1.0 1uvr Homo sapiens AGC_PDPK1_HUMAN AGC 9.8e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3NUNA O15530 71 358 556.0 JMZ:361 Type1 Inactive DFGin 6.4722 14.2209 BLAminus -136.64, 178.66 75.33, 84.73 -114.4, 16.28 293.69, 90.85 -60.42, -36.06 in-in in 8.6724 Saltbr-in 2.7874 HRD-in -68.71, -51.25 77.84, -3.6 in-in-out SNCiio in-out ActLoopNT-in 2.8357 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.38, 127.64 APE9-dihe-na -69.91, -151.05 APE8-dihe-in -80.37, 125.09 APE8-rot-in 310.77 APE67-dihe-in -66.15, -18.43 -42.77, -46.09 APE12-dist-in 8.9686 APE11-dist-out 5.8965 APE10-dist-out 10.4173 APE9-dist-in 4.3142 None SEP241 SEP241 XRAY 2.2 0.18 0.227 A 292.0 279.0 9 30 21 9 [[82, 342]] 1.0 3nun Homo sapiens AGC_PDPK1_HUMAN AGC 1e-84 289.6 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 2XCHA O15530 73 359 556.0 CKG:1360 Type1 Inactive DFGin 6.7339 14.5287 BLAminus -129.58, 177.2 73.14, 77.15 -102.2, 9.9 285.13, 96.86 -57.37, -39.89 in-in in 8.6981 Saltbr-in 2.571 HRD-in -76.48, -53.27 78.53, -7.84 in-in-out SNCiio in-out ActLoopNT-in 2.893 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.55, 124.18 APE9-dihe-na -77.48, -153.81 APE8-dihe-in -63.6, 127.96 APE8-rot-in 306.17 APE67-dihe-in -61.93, -18.13 -48.28, -49.39 APE12-dist-in 9.2863 APE11-dist-out 5.6905 APE10-dist-out 10.3423 APE9-dist-in 3.8907 None SEP241 SEP241 XRAY 2.0 0.191 0.226 A 309.0 279.0 8 30 22 8 [[82, 342]] 1.0 2xch Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 5HKMA O15530 76 358 556.0 61Y:403 Type1 Inactive DFGin 6.428 14.1502 BLAminus -122.57, -157.08 51.69, 73.85 -100.67, 14.09 281.12, 81.43 -62.59, -33.63 in-in in 8.6492 Saltbr-in 2.8074 HRD-in -66.63, -45.86 63.42, -2.09 in-in-out SNCiio in-out ActLoopNT-in 2.7614 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -140.98, 122.73 APE9-dihe-na -75.89, -160.0 APE8-dihe-in -62.57, 122.86 APE8-rot-in 309.65 APE67-dihe-in -56.46, -24.28 -29.66, -64.05 APE12-dist-in 9.6471 APE11-dist-out 5.8023 APE10-dist-out 10.2714 APE9-dist-in 3.7976 None SEP241 SEP241 XRAY 2.1 0.228 0.273 A 309.0 273.0 10 30 20 10 [[82, 342]] 1.0 5hkm Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 5HNGA O15530 71 359 556.0 62O:403 Type1 Inactive DFGin 6.5015 14.356 BLAminus -131.37, -170.36 61.15, 71.88 -92.77, 10.44 287.92, 92.83 -55.25, -43.3 in-in in 8.828 Saltbr-in 2.8729 HRD-in -61.06, -47.37 70.67, -1.21 in-in-out SNCiio in-out ActLoopNT-in 2.7991 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.82, 119.15 APE9-dihe-na -68.32, -153.72 APE8-dihe-in -67.95, 131.45 APE8-rot-in 305.81 APE67-dihe-in -63.0, -22.16 -48.07, -47.57 APE12-dist-in 9.0259 APE11-dist-out 5.7457 APE10-dist-out 10.5212 APE9-dist-in 4.0322 None SEP241 SEP241 XRAY 3.01 0.176 0.243 A 309.0 281.0 8 30 22 8 [[82, 342]] 1.0 5hng Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 5HO7A O15530 71 359 556.0 63L:701 Type1 Inactive DFGin 6.4996 13.9982 BLAminus -138.45, -177.98 79.97, 72.22 -103.24, 8.72 293.52, 91.58 -60.99, -44.96 in-in in 8.5843 Saltbr-in 3.0686 HRD-in -62.96, -39.76 64.33, -4.25 in-in-out SNCiio in-out ActLoopNT-in 2.9376 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.91, 120.25 APE9-dihe-na -71.94, -150.13 APE8-dihe-in -74.96, 128.19 APE8-rot-in 303.71 APE67-dihe-in -61.52, -27.36 -46.49, -48.45 APE12-dist-in 9.4591 APE11-dist-out 6.0158 APE10-dist-out 10.3175 APE9-dist-in 4.1229 None SEP241 SEP241 XRAY 3.0 0.175 0.233 A 309.0 281.0 8 30 22 8 [[82, 342]] 1.0 5ho7 Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 5HO8A O15530 71 358 556.0 63E:701 Type1 Inactive DFGin 6.3257 13.7271 BLAminus -137.78, 179.62 80.28, 69.7 -100.25, 11.3 296.62, 94.66 -58.72, -47.18 in-in in 8.7434 Saltbr-in 3.0233 HRD-in -65.39, -42.86 64.55, -6.55 in-in-out SNCiio in-out ActLoopNT-in 2.8667 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.41, 121.86 APE9-dihe-na -70.34, -152.74 APE8-dihe-in -66.74, 122.4 APE8-rot-in 293.45 APE67-dihe-in -65.08, -24.35 -41.28, -45.91 APE12-dist-in 9.1451 APE11-dist-out 5.9265 APE10-dist-out 10.2379 APE9-dist-in 4.0594 None SEP241 SEP241 XRAY 2.7 0.184 0.229 A 309.0 279.0 9 30 21 9 [[82, 342]] 1.0 5ho8 Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 1OKYA O15530 72 360 556.0 STU:1368 Type1 Inactive DFGin 6.1532 14.4616 BLAminus -148.97, -170.84 70.56, 80.45 -102.75, 23.82 286.84, 96.04 -69.28, -20.21 in-in in 8.6718 Saltbr-in 2.6729 HRD-in -67.69, -57.78 80.28, 0.43 in-in-out SNCiio in-out ActLoopNT-in 2.9341 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.7, -80.59 APE9-dihe-na 115.49, 169.91 APE8-dihe-in -54.49, 123.73 APE8-rot-in 316.76 APE67-dihe-in -63.35, -17.55 -42.07, -50.54 APE12-dist-in 9.2892 APE11-dist-out 5.5558 APE10-dist-out 9.7186 APE9-dist-in 4.222 None SEP241 SEP241 XRAY 2.3 0.219 0.255 A 310.0 283.0 6 30 24 6 [[82, 342]] 1.0 1oky Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 1OKZA O15530 73 359 556.0 UCN:1370 Type1 Inactive DFGin 6.5441 14.1675 BLAminus -141.57, -164.78 67.55, 76.85 -103.78, 11.05 287.85, 85.4 -63.67, 2.06 in-in in 8.7271 Saltbr-in 2.7175 HRD-in -70.44, -54.0 75.32, 3.69 in-in-out SNCiio in-out ActLoopNT-in 2.9208 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -147.16, 105.01 APE9-dihe-na -62.12, -140.62 APE8-dihe-in -78.85, 125.76 APE8-rot-in 304.75 APE67-dihe-in -63.07, -21.46 -38.09, -52.99 APE12-dist-in 9.5567 APE11-dist-out 6.099 APE10-dist-out 10.4075 APE9-dist-in 4.1656 None SEP241 SEP241 XRAY 2.51 0.19 0.257 A 310.0 278.0 9 30 21 9 [[82, 342]] 1.0 1okz Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 1UU3A O15530 73 360 556.0 LY4:1374 Type1 Inactive DFGin 6.5956 14.9714 BLAminus -134.47, -173.45 74.38, 73.99 -109.66, 0.57 283.46, 101.61 -63.98, -27.2 in-in in 8.2752 Saltbr-in 2.8167 HRD-in -64.65, -55.05 74.86, -6.55 in-in-out SNCiio in-out ActLoopNT-in 2.8643 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.92, 125.5 APE9-dihe-na -77.61, -163.62 APE8-dihe-in -56.98, 127.76 APE8-rot-in 299.91 APE67-dihe-in -61.39, -22.49 -53.63, -41.57 APE12-dist-in 9.2019 APE11-dist-out 5.4661 APE10-dist-out 10.4073 APE9-dist-in 4.0483 None SEP241 SEP241 XRAY 1.7 0.174 0.202 A 310.0 278.0 10 30 20 10 [[82, 342]] 1.0 1uu3 Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 1UU7A O15530 73 359 556.0 BI2:1364 Type1 Inactive DFGin 6.5571 14.7415 BLAminus -136.5, -171.94 74.29, 73.79 -109.8, -2.64 287.37, 96.13 -53.85, -39.14 in-in in 8.463 Saltbr-in 2.8801 HRD-in -68.07, -51.28 73.99, -8.84 in-in-out SNCiio in-out ActLoopNT-in 2.8332 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.82, 121.67 APE9-dihe-na -67.64, -173.23 APE8-dihe-in -49.06, 125.05 APE8-rot-in 301.64 APE67-dihe-in -67.12, -19.88 -49.14, -41.33 APE12-dist-in 8.9136 APE11-dist-out 5.317 APE10-dist-out 10.2667 APE9-dist-in 3.9105 None SEP241 SEP241 XRAY 1.9 0.235 0.279 A 310.0 282.0 5 30 25 5 [[82, 342]] 1.0 1uu7 Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 1UU8A O15530 72 358 556.0 BI1:1368 Type1 Inactive DFGin 6.6469 14.4714 BLAminus -136.37, -165.37 63.01, 71.98 -101.9, 2.54 288.65, 101.81 -58.08, -33.97 in-in in 8.8152 Saltbr-in 2.7275 HRD-in -71.97, -53.07 75.47, 11.05 in-in-out SNCiio in-out ActLoopNT-in 2.8428 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -142.67, 117.85 APE9-dihe-na -65.71, -160.29 APE8-dihe-in -63.31, 129.15 APE8-rot-in 297.13 APE67-dihe-in -68.38, -3.88 -40.88, -48.91 APE12-dist-in 9.2375 APE11-dist-out 5.6529 APE10-dist-out 10.0877 APE9-dist-in 3.759 None SEP241 SEP241 XRAY 2.5 0.176 0.258 A 310.0 279.0 8 30 22 8 [[82, 342]] 1.0 1uu8 Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3NAYA O15530 76 362 556.0 MP6:1 Type1 Inactive DFGin 6.7641 14.6579 BLAminus -146.79, -173.04 72.2, 70.67 -103.69, 5.05 296.95, 109.64 -60.79, -27.91 in-in in 8.5567 Saltbr-in 2.5649 HRD-in -62.07, -50.65 74.17, -9.68 in-in-out SNCiio in-out ActLoopNT-in 2.74 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.84, 118.23 APE9-dihe-na -69.99, -167.96 APE8-dihe-in -54.98, 129.37 APE8-rot-in 302.57 APE67-dihe-in -65.83, -27.98 -54.2, -37.6 APE12-dist-in 8.6002 APE11-dist-out 5.6186 APE10-dist-out 10.5309 APE9-dist-in 3.8392 None SEP241 SEP241 XRAY 2.6 0.211 0.274 A 311.0 279.0 8 30 22 8 [[82, 342]] 1.0 3nay Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3NAYB O15530 76 362 556.0 MP6:2 Type1 Inactive DFGin 6.8794 14.3665 BLAminus -131.67, -178.35 72.0, 77.09 -107.77, 17.41 299.66, 102.49 -69.46, -28.42 in-in in 8.3299 Saltbr-in 2.8238 HRD-in -70.5, -49.88 76.39, -13.79 in-in-out SNCiio in-out ActLoopNT-in 2.8417 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 114.84, 100.21 APE9-dihe-na -68.09, -163.03 APE8-dihe-in -59.66, 125.08 APE8-rot-in 300.78 APE67-dihe-in -68.69, -23.52 -42.99, -40.54 APE12-dist-in 8.7294 APE11-dist-out 5.8365 APE10-dist-out 10.6017 APE9-dist-in 3.8844 None SEP241 SEP241 XRAY 2.6 0.211 0.274 B 311.0 279.0 8 30 22 8 [[82, 342]] 1.0 3nay Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3RWPA O15530 73 359 556.0 ABQ:360 Type1 Inactive DFGin 6.6301 14.6122 BLAminus -138.06, -171.84 73.21, 68.9 -101.84, 0.77 284.24, 99.91 -67.12, -24.97 in-in in 8.4872 Saltbr-in 2.668 HRD-in -72.19, -48.95 75.52, -7.14 in-in-out SNCiio in-out ActLoopNT-in 2.8439 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.4, 122.62 APE9-dihe-na -64.5, -165.33 APE8-dihe-in -62.97, 132.8 APE8-rot-in 302.69 APE67-dihe-in -57.73, -26.43 -57.73, -39.86 APE12-dist-in 9.571 APE11-dist-out 5.748 APE10-dist-out 10.613 APE9-dist-in 4.2017 None SEP241 SEP241 XRAY 1.92 0.174 0.213 A 311.0 278.0 9 30 21 9 [[82, 342]] 1.0 3rwp Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3RWQA O15530 72 359 556.0 3RW:1 Type1 Inactive DFGin 6.5891 14.463 BLAminus -143.65, -172.61 68.52, 70.31 -102.07, 3.38 289.03, 95.5 -56.64, -39.2 in-in in 8.5646 Saltbr-in 2.7282 HRD-in -70.4, -52.28 81.8, -9.17 in-in-out SNCiio in-out ActLoopNT-in 3.02 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.88, 122.18 APE9-dihe-na -69.74, -149.03 APE8-dihe-in -75.72, 125.93 APE8-rot-in 318.02 APE67-dihe-in -73.55, -21.89 -37.75, -44.68 APE12-dist-in 9.2067 APE11-dist-out 5.8786 APE10-dist-out 10.5237 APE9-dist-in 4.0165 None SEP241 SEP241 XRAY 2.55 0.196 0.256 A 311.0 284.0 4 30 26 4 [[82, 342]] 1.0 3rwq Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3H9OA O15530 75 359 556.0 9BD:1 Type1 Inactive DFGin 6.5678 14.261 BLAminus -131.94, -168.71 66.62, 79.57 -104.6, 18.2 283.3, 82.81 -72.27, -11.03 in-in in 8.8763 Saltbr-in 2.5436 HRD-in -78.26, -52.42 80.3, -1.11 in-in-out SNCiio in-out ActLoopNT-in 2.8097 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 77.5, 119.89 APE9-dihe-na -89.12, -112.65 APE8-dihe-in -101.23, 134.92 APE8-rot-in 301.13 APE67-dihe-in -62.27, -18.27 -50.83, -50.03 APE12-dist-in 9.6432 APE11-dist-out 6.2678 APE10-dist-out 10.1736 APE9-dist-in 3.934 None SEP241 SEP241 XRAY 2.3 0.211 0.256 A 311.0 276.0 9 30 21 9 [[82, 342]] 1.0 3h9o Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 2R7BA O15530 75 359 556.0 253:701 Type1 Inactive DFGin 6.1992 14.366 BLAminus -133.94, -179.49 77.82, 81.49 -108.24, 22.02 291.13, 86.98 -68.69, -10.97 in-in in 8.8662 Saltbr-in 2.5883 HRD-in -75.75, -47.44 52.14, 30.84 in-in-out SNCiio in-out ActLoopNT-in 2.7982 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 148.51, 113.35 APE9-dihe-na -77.58, -157.1 APE8-dihe-in -58.21, 135.29 APE8-rot-in 301.99 APE67-dihe-in -57.75, -20.67 -44.89, -55.44 APE12-dist-in 9.1968 APE11-dist-out 5.7727 APE10-dist-out 9.8875 APE9-dist-in 4.0959 None SEP241 SEP241 XRAY 2.7 0.225 0.25 A 312.0 275.0 10 30 20 10 [[82, 342]] 1.0 2r7b Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3IONA O15530 75 359 556.0 8H1:1 Type1 Inactive DFGin 6.3855 14.0119 BLAminus -129.57, -169.56 64.12, 80.16 -106.23, 22.91 285.85, 87.72 -68.81, -24.37 in-in in 8.9313 Saltbr-in 3.3369 HRD-in -74.01, -54.84 77.47, 1.06 in-in-out SNCiio in-out ActLoopNT-in 2.7001 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 132.89 APE9-dihe-na -88.46, -116.13 APE8-dihe-in -104.9, 134.52 APE8-rot-in 307.56 APE67-dihe-in -73.92, -18.65 -45.98, -45.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.0803 APE9-dist-in 3.6029 None None None XRAY 2.4 0.246 0.282 A 312.0 274.0 11 30 19 11 [[82, 342]] 1.0 3ion Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3IOPA O15530 75 359 556.0 8I1:1 Type1 Inactive DFGin 6.6057 14.3164 BLAminus -125.3, -165.97 58.12, 80.1 -105.24, 23.38 285.73, 86.81 -73.19, -11.32 in-in in 8.8064 Saltbr-in 2.6809 HRD-in -71.7, -52.98 78.46, -5.63 in-in-out SNCiio in-out ActLoopNT-in 2.8075 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 67.02, 113.91 APE9-dihe-na -74.5, -127.28 APE8-dihe-in -97.61, 129.5 APE8-rot-in 303.0 APE67-dihe-in -63.74, -18.61 -44.16, -50.92 APE12-dist-in 9.5697 APE11-dist-out 5.9687 APE10-dist-out 10.4647 APE9-dist-in 3.7908 None SEP241 SEP241 XRAY 2.2 0.24 0.278 A 312.0 276.0 9 30 21 9 [[82, 342]] 1.0 3iop Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3QCQA O15530 73 358 556.0 3Q0:370 Type1 Inactive DFGin 6.286 13.9428 BLAminus -130.07, -172.39 67.81, 84.85 -116.19, 10.14 290.92, 91.68 -60.0, -35.96 in-in in 8.6682 Saltbr-in 2.8169 HRD-in -76.77, -43.93 72.04, -4.3 in-in-out SNCiio in-out ActLoopNT-in 2.9565 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.34, 117.15 APE9-dihe-na -68.0, -161.08 APE8-dihe-in -59.72, 132.52 APE8-rot-in 308.25 APE67-dihe-in -73.95, -13.03 -56.44, -42.24 APE12-dist-in 9.3219 APE11-dist-out 6.2157 APE10-dist-out 10.3256 APE9-dist-in 4.2085 None SEP241 SEP241 XRAY 2.501 0.181 0.251 A 312.0 277.0 9 30 21 9 [[82, 342]] 1.0 3qcq Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3QCSA O15530 73 358 556.0 3Q1:370 Type1 Inactive DFGin 6.4977 14.3423 BLAminus -129.15, -172.55 69.95, 84.25 -118.54, 4.81 283.02, 93.04 -59.77, -28.42 in-in in 8.591 Saltbr-in 2.8075 HRD-in -71.62, -47.65 74.15, -7.51 in-in-out SNCiio in-out ActLoopNT-in 2.8349 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -125.7, 120.85 APE9-dihe-na -72.97, -164.1 APE8-dihe-in -54.02, 130.58 APE8-rot-in 312.22 APE67-dihe-in -61.81, -24.07 -54.55, -47.19 APE12-dist-in 9.2353 APE11-dist-out 6.3341 APE10-dist-out 10.5363 APE9-dist-in 4.4067 None SEP241 SEP241 XRAY 2.487 0.182 0.251 A 312.0 277.0 9 30 21 9 [[82, 342]] 1.0 3qcs Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3PWYA O15530 71 359 556.0 SYP:1 Type1 Inactive DFGin 6.477 14.4835 BLAminus -124.65, -178.35 67.96, 96.3 -130.58, 11.45 300.55, 97.42 -64.93, -31.03 in-in in 8.587 Saltbr-in 2.6927 HRD-in -58.86, -48.53 68.39, -3.99 in-in-out SNCiio in-out ActLoopNT-in 2.761 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.65, 129.21 APE9-dihe-na -78.78, -151.6 APE8-dihe-in -77.12, 126.15 APE8-rot-in 307.61 APE67-dihe-in -78.87, -27.54 -44.08, -37.51 APE12-dist-in 10.3267 APE11-dist-out 5.848 APE10-dist-out 10.5798 APE9-dist-in 3.8548 E166C,C260S None None XRAY 3.5 0.226 0.276 A 311.0 281.0 8 30 22 8 [[82, 342]] 1.0 3pwy Homo sapiens AGC_PDPK1_HUMAN AGC 9.5e-84 286.4 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 2XCKA O15530 76 359 556.0 MH4:1360 Type1 Inactive DFGin 6.7771 14.7278 BLAminus -138.18, -175.27 71.05, 75.56 -104.69, 7.11 286.41, 101.4 -56.07, -44.06 in-in in 8.7216 Saltbr-in 2.7225 HRD-in -74.69, -54.88 79.61, -3.05 in-in-out SNCiio in-out ActLoopNT-in 2.891 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -108.24, 134.08 APE9-dihe-na -87.44, -159.07 APE8-dihe-in -56.55, 126.47 APE8-rot-in 304.89 APE67-dihe-in -62.34, -18.12 -47.8, -48.47 APE12-dist-in 9.3328 APE11-dist-out 5.5135 APE10-dist-out 10.4019 APE9-dist-in 3.8752 None SEP241 SEP241 XRAY 2.3 0.195 0.24 A 309.0 276.0 8 30 22 8 [[82, 342]] 1.0 2xck Homo sapiens AGC_PDPK1_HUMAN AGC 1.8e-83 285.5 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3QCXA O15530 73 358 556.0 3Q2:370 Type1.5_Back Inactive DFGin 6.5656 14.4479 BLAminus -128.85, -170.97 71.83, 79.3 -115.33, 7.3 284.13, 92.7 -60.73, -28.9 in-in in 8.4024 Saltbr-in 2.7064 HRD-in -68.18, -50.11 76.96, -14.11 in-in-out SNCiio in-out ActLoopNT-in 2.8031 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -135.89, 122.06 APE9-dihe-na -67.11, -167.83 APE8-dihe-in -62.01, 135.81 APE8-rot-in 308.12 APE67-dihe-in -61.25, -24.88 -55.14, -44.7 APE12-dist-in 9.4652 APE11-dist-out 6.3732 APE10-dist-out 10.3227 APE9-dist-in 4.269 None SEP241 SEP241 XRAY 2.3 0.184 0.225 A 312.0 277.0 9 30 21 9 [[82, 342]] 1.0 3qcx Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3QCYA O15530 73 358 556.0 3Q3:371 Type1.5_Front Inactive DFGin 6.3885 14.5918 BLAminus -136.93, -173.16 70.99, 75.14 -110.32, 14.26 284.13, 86.28 -62.73, -28.34 in-in in 8.4189 Saltbr-in 2.559 HRD-in -71.32, -53.51 82.01, -8.81 in-in-out SNCiio in-out ActLoopNT-in 2.825 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 125.83 APE9-dihe-na -76.07, -148.77 APE8-dihe-in -79.07, 127.11 APE8-rot-in 312.38 APE67-dihe-in -58.65, -24.48 -40.2, -55.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.317 APE9-dist-in 4.4989 None SEP241 SEP241 XRAY 2.2 0.181 0.212 A 312.0 275.0 11 30 19 11 [[82, 342]] 1.0 3qcy Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3QD3A O15530 71 358 556.0 3Q5:360 Type1.5_Front Inactive DFGin 6.6397 14.7756 BLAminus -136.15, -173.35 75.08, 78.84 -114.86, 7.79 284.21, 92.48 -60.8, -30.07 in-in in 8.4699 Saltbr-in 2.5474 HRD-in -69.84, -52.9 76.92, -8.58 in-in-out SNCiio in-out ActLoopNT-in 2.8112 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -114.87, 124.76 APE9-dihe-na -70.78, -165.19 APE8-dihe-in -61.65, 129.32 APE8-rot-in 306.27 APE67-dihe-in -62.1, -22.78 -46.86, -49.49 APE12-dist-in 8.9916 APE11-dist-out 5.7339 APE10-dist-out 10.4141 APE9-dist-in 4.0376 None SEP241 SEP241 XRAY 2.0 0.185 0.211 A 312.0 279.0 9 30 21 9 [[82, 342]] 1.0 3qd3 Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3NAXA O15530 76 360 556.0 MP7:363 Type2 Inactive DFGout 15.1303 9.5196 BBAminus -103.03, 154.8 -117.91, 140.31 -115.35, 34.44 271.6, 90.85 93.28, 8.79 out-out out 17.0845 Saltbr-out 10.2575 HRD-in -72.23, -50.17 78.89, -10.91 out-in-none SNCoin in-none ActLoopNT-in 2.8524 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.19, -19.08 999.0, -56.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.166 0.195 A 311.0 278.0 7 30 23 7 [[82, 342]] 1.0 3nax Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3QC4A O15530 76 359 556.0 MP7:60001 Type2 Inactive DFGout 15.1445 8.4181 BBAminus -116.84, 146.54 -96.89, 143.53 -123.04, 29.2 249.8, 111.12 113.47, -5.45 out-out out 19.868 Saltbr-out 17.8176 HRD-in -79.45, -51.8 76.86, -8.13 out-in-in SNCoii in-in ActLoopNT-in 3.035 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.28, 161.52 APE9-dihe-na 127.76, -165.1 APE8-dihe-in -132.92, 137.19 APE8-rot-in 293.31 APE67-dihe-in -63.51, -29.78 -55.77, -40.56 APE12-dist-in 7.6463 APE11-dist-in 10.8912 APE10-dist-in 5.0977 APE9-dist-in 3.6028 E303A,K304A SEP241 SEP241 XRAY 1.8 0.174 0.213 A 314.0 277.0 7 30 23 7 [[82, 342]] 1.0 3qc4 Homo sapiens AGC_PDPK1_HUMAN AGC 5.4e-84 287.2 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3QC4B O15530 51 359 556.0 MP7:60002 Type2 Inactive DFGout 15.5034 8.2994 None -106.7, 145.77 -96.8, 153.42 -131.45, 34.1 235.15, 115.54 107.65, 4.91 out-out out 18.0578 Saltbr-out 15.1697 HRD-in -74.82, -53.49 77.73, -9.15 out-in-in SNCoii in-in ActLoopNT-in 2.9345 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.95, 158.08 APE9-dihe-na 130.3, -155.43 APE8-dihe-in -143.11, 135.86 APE8-rot-in 293.55 APE67-dihe-in -66.08, -20.71 -55.87, -43.65 APE12-dist-in 7.6714 APE11-dist-in 10.9464 APE10-dist-in 5.0678 APE9-dist-in 3.5388 E303A,K304A SEP241 SEP241 XRAY 1.8 0.174 0.213 B 314.0 274.0 15 30 23 7 [[82, 342]] 1.0 3qc4 Homo sapiens AGC_PDPK1_HUMAN AGC 5.4e-84 287.2 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 4CT1A O15530 76 359 556.0 ATP:500,31S:600 ATPlike,Allosteric None DFGin 6.6022 14.9785 BLAminus -141.71, -172.51 72.43, 72.08 -107.06, 8.07 284.9, 97.13 -62.67, -20.12 in-none in 8.1463 Saltbr-none 999.0 HRD-in -74.62, -54.47 79.43, -8.97 none-in-in SNCnii in-in ActLoopNT-in 2.9992 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.29, 160.89 APE9-dihe-na 137.85, -171.95 APE8-dihe-in -126.26, 129.35 APE8-rot-in 296.2 APE67-dihe-in -61.08, -24.26 -47.64, -46.5 APE12-dist-in 7.3566 APE11-dist-in 10.4885 APE10-dist-in 5.0182 APE9-dist-in 3.4798 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A SEP241 SEP241 XRAY 1.85 0.172 0.215 A 311.0 284.0 0 30 30 0 [[82, 342]] 1.0 4ct1 Homo sapiens AGC_PDPK1_HUMAN AGC 9.5e-84 286.4 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3QD0A O15530 73 358 556.0 3Q4:370 Type1.5_Front None DFGin 6.5836 14.7913 BLAminus -135.89, -173.14 73.55, 73.02 -106.35, 12.12 281.49, 88.39 -54.84, -35.9 in-in in 8.5258 Saltbr-in 2.5731 HRD-in -72.98, -50.98 74.13, -9.69 in-in-none SNCiin in-none ActLoopNT-in 2.8508 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.13 APE8-dihe-in -74.4, 123.75 APE8-rot-in 309.46 APE67-dihe-in -59.36, -28.41 -43.01, -50.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.7652 None SEP241 SEP241 XRAY 1.99 0.191 0.231 A 312.0 274.0 12 30 18 12 [[82, 342]] 1.0 3qd0 Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
PDPK1 PDPK1_HUMAN 3QD4A O15530 71 358 556.0 3Q6:360 Type1.5_Front None DFGin 6.4034 14.6264 BLAminus -137.72, -173.39 72.99, 75.84 -110.69, 10.4 285.12, 91.81 -64.41, -29.28 in-in in 8.5579 Saltbr-in 2.7898 HRD-in -69.09, -51.69 76.33, -7.4 in-in-none SNCiin in-none ActLoopNT-in 2.9076 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -153.49 APE8-dihe-in -83.46, 122.24 APE8-rot-in 298.92 APE67-dihe-in -62.96, -22.94 -34.73, -56.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.1203 None SEP241 SEP241 XRAY 2.3 0.199 0.244 A 312.0 276.0 12 30 18 12 [[82, 342]] 1.0 3qd4 Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1

AGC_PDPK1 (3-phosphoinositide-dependent protein kinase 1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name