Ligand: BI1

Total number of chains: 5
Active chains: 4
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 100.0% 1XWSA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC PDPK1 PDPK1_HUMAN 1UU8A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi BI1 Type1 72 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
AGC PRKCI KPCI_HUMAN 1ZRZA 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BI1 Type1 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type
CAMK PIM1 PIM1_HUMAN 1XWSA 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BI1 Type1 33 - 305 0 None None Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2BIKB 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BI1 Type1 33 - 305 0 SEP261 None Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2BILB 2.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BI1 Type1 33 - 306 0 None None Serine/threonine-protein kinase pim-1

Ligand: BI1

Total number of chains: 6
Active chains: 4
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 83.3% 1XWSA
DFGin BLBplus 1 16.7% 9EJXA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC PDPK1 PDPK1_HUMAN 1UU8A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi BI1 Type1 72 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PRKCI KPCI_HUMAN 1ZRZA 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BI1 Type1 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
CAMK PIM1 PIM1_HUMAN 1XWSA 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BI1 Type1 33 - 305 0 None None Serine/threonine-protein kinase pim-1 Homo sapiens
CAMK PIM1 PIM1_HUMAN 2BIKB 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BI1 Type1 33 - 305 0 SEP261 None Serine/threonine-protein kinase pim-1 Homo sapiens
CAMK PIM1 PIM1_HUMAN 2BILB 2.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BI1 Type1 33 - 306 0 None None Serine/threonine-protein kinase pim-1 Homo sapiens
TYR BTK BTK_MOUSE 9EJXA 2.86 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao A1BI1 Type1.5_Back 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus

Ligand: BI1

Total number of chains: 1
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 1 100.0% 9EJXA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR BTK BTK_MOUSE 9EJXA 2.86 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_oiiai APEdist_aaao A1BI1 Type1.5_Back 396 - 659 0 None K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P Tyrosine-protein kinase BTK Mus musculus