OTHER_ERN1 (Serine/threonine-protein kinase/endoribonuclease IRE1)

Total number of chains: 50
Active chains: 8
Uniprot: ERN1_HUMAN
Kinase Domain Residues: 569 - 832
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 28 56.0% AF-O75460-K1A
DFGin BLBplus 13 26.0% 3P23C
DFGin None 3 6.0% 4Z7HA
DFGout None 3 6.0% 4YZ9A
None None 2 4.0% 6HX1A
DFGin ABAminus 1 2.0% 4Z7HB

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ERN1 AF-O75460-K1A O75460 561 840 977.0 No_ligand No_ligand Active DFGin 5.2263 14.3584 BLAminus -136.1, 174.69 62.75, 82.9 -90.11, 8.09 278.92, 58.01 -56.59, -35.42 in-in in 8.6229 Saltbr-in 2.7387 HRD-in -70.55, -49.28 65.1, -0.16 in-in-in SNCiii in-in ActLoopNT-in 2.8855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.61, 153.38 APE9-dihe-na 118.83, 174.73 APE8-dihe-in -98.29, 131.32 APE8-rot-in 303.59 APE67-dihe-inflip 83.09, -9.62 -47.44, 134.97 APE12-dist-in 10.8728 APE11-dist-in 11.1467 APE10-dist-in 5.2379 APE9-dist-in 3.29 None None None AF2 -1.0 1.0 1.0 A 280.0 280.0 0 31 31 0 [[571, 832]] 1.0 AF-O75460-K1 OTHER_ERN1_HUMAN CAMK 8.3e-36 129.6 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 AF-O75460-K3A O75460 561 840 977.0 No_ligand No_ligand Active DFGin 5.2492 14.1487 BLAminus -135.31, -174.96 58.8, 76.05 -86.75, 1.33 278.92, 66.56 -57.5, -35.04 in-in in 8.4609 Saltbr-in 2.6786 HRD-in -73.71, -47.28 67.17, -7.9 in-in-in SNCiii in-in ActLoopNT-in 2.7771 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -67.31, 152.38 APE9-dihe-na 117.01, 175.14 APE8-dihe-in -93.16, 133.21 APE8-rot-in 303.49 APE67-dihe-inflip 79.17, -0.04 -48.5, 133.79 APE12-dist-in 10.8937 APE11-dist-in 11.1975 APE10-dist-in 5.3029 APE9-dist-in 3.4198 None None None AF2 -1.0 1.0 1.0 A 280.0 280.0 0 31 31 0 [[571, 832]] 1.0 AF-O75460-K3 OTHER_ERN1_HUMAN CAMK 8.3e-36 129.6 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6W3CA O75460 560 964 977.0 No_ligand No_ligand Active DFGin 6.1058 14.2357 BLAminus -143.3, -169.77 61.92, 75.26 -99.59, 5.17 293.74, 80.96 -57.56, -26.8 in-in in 8.19 Saltbr-in 2.4383 HRD-in -73.83, -48.09 71.71, -9.73 in-in-in SNCiii in-in ActLoopNT-in 2.8021 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -71.3, -33.45 APE9-dihe-na -62.43, 169.01 APE8-dihe-in -93.38, 133.53 APE8-rot-in 300.11 APE67-dihe-inflip 106.95, -8.39 -49.76, 124.1 APE12-dist-in 11.2447 APE11-dist-in 11.3955 APE10-dist-in 5.4301 APE9-dist-in 3.4493 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.3 0.208 0.248 A 434.0 405.0 0 31 31 0 [[571, 832]] 1.0 6w3c OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6W3CB O75460 560 963 977.0 No_ligand No_ligand Active DFGin 6.1058 14.899 BLAminus -154.48, -168.03 55.85, 78.98 -100.05, 13.54 285.56, 16.26 -60.83, -29.52 in-in in 8.3655 Saltbr-in 2.6337 HRD-in -75.16, -45.21 69.8, 0.87 in-in-in SNCiii in-in ActLoopNT-in 2.7083 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -79.23, 157.93 APE9-dihe-na 117.83, 146.57 APE8-dihe-in -81.19, 135.69 APE8-rot-in 308.77 APE67-dihe-inflip 111.32, -6.95 -54.24, 124.62 APE12-dist-in 10.8874 APE11-dist-in 10.8973 APE10-dist-in 4.9571 APE9-dist-in 3.5412 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.3 0.208 0.248 B 434.0 404.0 0 31 31 0 [[571, 832]] 1.0 6w3c OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6W3CC O75460 560 963 977.0 No_ligand No_ligand Active DFGin 5.657 15.0187 BLAminus -147.84, -172.12 60.8, 76.5 -95.31, 10.61 280.4, 53.86 -59.0, -26.79 in-in in 8.706 Saltbr-in 2.7208 HRD-in -80.88, -50.26 69.52, 4.83 in-in-in SNCiii in-in ActLoopNT-in 2.9577 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -79.43, 153.53 APE9-dihe-na 125.25, 174.09 APE8-dihe-in -105.72, 131.11 APE8-rot-in 300.67 APE67-dihe-inflip 110.66, -4.8 -51.94, 122.81 APE12-dist-in 11.2388 APE11-dist-in 11.1201 APE10-dist-in 5.2179 APE9-dist-in 3.6747 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.3 0.208 0.248 C 434.0 404.0 0 31 31 0 [[571, 832]] 1.0 6w3c OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6W3CD O75460 560 963 977.0 No_ligand No_ligand Active DFGin 5.9323 15.058 BLAminus -157.54, -163.82 60.31, 71.97 -98.14, 3.34 281.98, 17.28 -56.04, -29.73 in-in in 8.6424 Saltbr-in 2.7148 HRD-in -75.91, -46.58 71.49, -6.58 in-in-in SNCiii in-in ActLoopNT-in 2.71 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -80.66, -18.6 APE9-dihe-na -64.06, 167.42 APE8-dihe-in -92.49, 134.25 APE8-rot-in 304.43 APE67-dihe-inflip 103.66, -4.02 -51.74, 125.98 APE12-dist-in 11.3016 APE11-dist-in 11.2182 APE10-dist-in 5.2576 APE9-dist-in 3.4824 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.3 0.208 0.248 D 434.0 404.0 0 31 31 0 [[571, 832]] 1.0 6w3c OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 9GOWA O75460 562 964 977.0 A1IOO:1001 Type1 Active DFGin 5.7525 15.8477 BLAminus -137.11, -164.14 55.29, 61.49 -82.92, 7.86 279.34, 27.53 -61.24, -35.15 in-in in 9.2808 Saltbr-in 3.2173 HRD-in -66.48, -56.29 77.33, -1.62 in-in-in SNCiii in-in ActLoopNT-in 2.9617 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -75.9, 139.91 APE9-dihe-na 137.0, 174.42 APE8-dihe-in -105.74, 137.36 APE8-rot-in 313.93 APE67-dihe-inflip 116.47, -18.45 -55.17, 118.89 APE12-dist-in 10.6547 APE11-dist-in 11.2725 APE10-dist-in 5.2365 APE9-dist-in 3.6305 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 3.0 0.234 0.281 A 434.0 403.0 0 31 31 0 [[571, 832]] 1.0 9gow OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 9GOWC O75460 562 964 977.0 A1IOO:1001 Type1 Active DFGin 5.6346 15.5587 BLAminus -132.52, 179.7 73.16, 53.18 -77.31, 13.24 285.48, 55.31 -73.1, -19.29 in-in in 9.0393 Saltbr-in 3.0186 HRD-in -82.58, -51.91 71.45, 18.84 in-in-in SNCiii in-in ActLoopNT-in 2.6297 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -81.81, 130.02 APE9-dihe-na 148.27, 178.17 APE8-dihe-in -119.07, 134.7 APE8-rot-in 323.09 APE67-dihe-inflip 99.28, -15.5 -52.59, 133.44 APE12-dist-in 10.7733 APE11-dist-in 11.2227 APE10-dist-in 5.3477 APE9-dist-in 3.6646 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 3.0 0.234 0.281 C 434.0 403.0 0 31 31 0 [[571, 832]] 1.0 9gow OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 4Z7HB O75460 562 962 977.0 4L5:1001 Type1 Inactive DFGin 5.1351 14.5181 ABAminus -147.31, -25.96 -101.01, 93.63 -84.21, 0.58 280.19, 77.98 -61.73, -35.98 in-in in 8.2947 Saltbr-in 2.8804 HRD-in -73.65, -45.51 64.99, 2.13 in-in-out SNCiio in-out ActLoopNT-in 2.9362 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioi APE10-dihe-na -82.39, -0.49 APE9-dihe-na 151.41, -152.92 APE8-dihe-in -124.62, 124.86 APE8-rot-out 45.76 APE67-dihe-inflip 103.66, -22.96 -54.37, 143.35 APE12-dist-none 999.0 APE11-dist-in 8.4359 APE10-dist-out 8.7362 APE9-dist-in 4.695 None None None XRAY 2.9 0.202 0.225 B 416.0 388.0 13 31 24 7 [[571, 832]] 1.0 4z7h OTHER_ERN1_HUMAN CAMK 3e-35 128.0 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 5HGIA O75460 562 964 977.0 No_ligand No_ligand Inactive DFGin 5.6094 14.6427 BLAminus -145.05, -173.6 59.23, 77.97 -93.33, 15.89 299.4, 90.09 -56.25, -41.67 in-in in 8.8345 Saltbr-in 3.0851 HRD-in -70.44, -52.16 82.22, -6.2 in-in-out SNCiio in-out ActLoopNT-in 2.8046 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -73.82, 158.67 APE9-dihe-na -55.87, 177.33 APE8-dihe-in -86.18, 152.71 APE8-rot-in 291.18 APE67-dihe-inflip 109.66, -27.51 -52.0, 151.26 APE12-dist-in 7.7156 APE11-dist-out 6.8495 APE10-dist-out 9.2179 APE9-dist-in 4.3624 None None None XRAY 2.584 0.214 0.247 A 431.0 395.0 5 31 31 0 [[571, 832]] 1.0 5hgi OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6XDFB O75460 562 964 977.0 No_ligand No_ligand Inactive DFGin 5.7339 14.8635 BLAminus -147.47, -177.07 57.93, 76.76 -96.5, 15.93 283.55, 47.82 -59.81, -43.08 in-in in 8.2284 Saltbr-in 2.7368 HRD-in -73.76, -49.3 76.45, -0.87 in-in-out SNCiio in-out ActLoopNT-in 2.876 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnio APE10-dihe-na 999.0, -169.01 APE9-dihe-na 101.44, -83.65 APE8-dihe-in -134.49, 143.31 APE8-rot-in 313.33 APE67-dihe-inflip 129.9, -41.41 -81.7, 159.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.524 APE9-dist-out 7.4378 None None None XRAY 2.54 0.209 0.263 B 431.0 400.0 3 31 29 2 [[571, 832]] 1.0 6xdf OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6W3BA O75460 562 963 977.0 No_ligand No_ligand Inactive DFGin 5.2814 15.0145 BLAminus -143.27, -170.93 56.51, 82.48 -97.69, 18.76 283.82, 27.48 -70.15, -29.01 in-in in 9.0168 Saltbr-in 3.226 HRD-in -67.85, -45.67 72.89, 0.99 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -72.27, -21.84 APE9-dihe-na 147.89, -147.39 APE8-dihe-in -108.47, 126.95 APE8-rot-in 297.0 APE67-dihe-inflip 99.73, -10.05 -56.76, 133.68 APE12-dist-in 7.5063 APE11-dist-out 7.5768 APE10-dist-out 10.0403 APE9-dist-in 4.0185 None None None XRAY 2.57 0.206 0.246 A 434.0 398.0 0 31 31 0 [[571, 832]] 1.0 6w3b OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 9GOWB O75460 562 964 977.0 A1IOO:1001 Type1 Inactive DFGin 5.6591 15.5949 BLAminus -145.27, -164.83 46.92, 70.18 -87.21, 11.29 280.69, 69.55 -62.43, -36.43 in-in in 9.514 Saltbr-in 2.9159 HRD-in -81.2, -46.9 74.25, -11.86 in-in-out SNCiio in-out ActLoopNT-in 2.9113 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -59.45, 144.76 APE9-dihe-na 126.14, -167.15 APE8-dihe-in -135.75, 140.85 APE8-rot-out 210.8 APE67-dihe-inflip 99.64, -22.14 -57.98, 140.11 APE12-dist-in 10.8024 APE11-dist-in 11.1995 APE10-dist-in 5.274 APE9-dist-in 3.5398 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 3.0 0.234 0.281 B 434.0 403.0 0 31 31 0 [[571, 832]] 1.0 9gow OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 9GOWD O75460 562 964 977.0 A1IOO:1001 Type1 Inactive DFGin 5.8771 15.9408 BLAminus -144.08, -162.9 48.88, 78.62 -99.04, 18.45 261.61, 69.28 -69.53, -42.63 in-out in 9.4744 Saltbr-out 3.6973 HRD-in -82.34, -51.42 71.84, 19.12 out-in-out SNCoio in-out ActLoopNT-in 2.8911 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -60.38, 141.0 APE9-dihe-na 147.72, -174.34 APE8-dihe-in -119.1, 140.61 APE8-rot-out 31.47 APE67-dihe-inflip 82.22, -18.82 -56.96, 151.1 APE12-dist-in 10.9652 APE11-dist-in 11.5215 APE10-dist-in 5.4482 APE9-dist-in 3.9357 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 3.0 0.234 0.281 D 434.0 303.0 2 31 31 0 [[571, 832]] 1.0 9gow OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6W3EB O75460 563 963 977.0 SJV:1001 Type1.5_Back Inactive DFGin 5.7951 15.5172 BLAminus -141.88, 176.99 63.2, 84.04 -105.56, 28.54 300.08, 169.13 -67.07, -42.47 out-out out 10.1071 Saltbr-out 5.7074 HRD-out -80.93, 139.0 -122.23, -35.4 out-in-out SNCoio in-out ActLoopNT-in 2.9439 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -5.99 APE9-dihe-na -74.91, 153.53 APE8-dihe-out 63.33, 175.78 APE8-rot-out 67.1 APE67-dihe-inflip 108.9, -22.83 -150.99, 138.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.1462 APE9-dist-out 6.983 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.737 0.267 0.317 B 431.0 389.0 12 31 27 4 [[571, 832]] 1.0 6w3e OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6XDFA O75460 560 966 977.0 N94:1002 Type1.5_Back Inactive DFGin 6.3826 15.1993 BLAminus -130.29, -176.4 60.9, 76.83 -90.68, 29.29 294.67, 76.62 -70.73, -33.39 out-out out 10.1564 Saltbr-out 5.0934 HRD-in -82.04, -48.49 78.58, -9.6 out-in-out SNCoio in-out ActLoopNT-in 3.0092 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -73.17, -32.0 APE9-dihe-na 161.12, -145.76 APE8-dihe-in -111.23, 117.63 APE8-rot-in 300.24 APE67-dihe-inflip 110.41, -26.97 -49.33, 126.92 APE12-dist-in 7.6298 APE11-dist-out 6.918 APE10-dist-out 9.7984 APE9-dist-in 3.8602 None None None XRAY 2.54 0.209 0.263 A 431.0 402.0 5 31 31 0 [[571, 832]] 1.0 6xdf OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 7BMKA O75460 561 966 977.0 U4N:1001 Type1.5_Back Inactive DFGin 5.3046 15.6038 BLAminus -134.78, 175.72 71.56, 88.08 -95.42, 16.11 280.14, 64.53 -63.54, -33.93 out-out out 10.6201 Saltbr-out 5.4292 HRD-in -79.03, -50.32 75.82, -1.9 out-in-out SNCoio in-out ActLoopNT-in 2.8637 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -71.86, -22.99 APE9-dihe-na 146.38, -151.63 APE8-dihe-in -103.7, 128.54 APE8-rot-in 300.23 APE67-dihe-inflip 91.08, -11.6 -49.87, 131.36 APE12-dist-in 7.4825 APE11-dist-out 7.0097 APE10-dist-out 9.895 APE9-dist-in 3.7159 None None None XRAY 1.85 0.192 0.235 A 434.0 406.0 0 31 31 0 [[571, 832]] 1.0 7bmk OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 7BMKB O75460 562 963 977.0 U4N:1001 Type1.5_Back Inactive DFGin 5.4699 15.5574 BLAminus -136.75, 176.32 69.57, 85.31 -94.6, 15.21 280.65, 62.8 -61.14, -35.65 out-out out 10.4246 Saltbr-out 5.2954 HRD-in -76.97, -51.76 73.84, 1.59 out-in-out SNCoio in-out ActLoopNT-in 2.8504 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioio APE10-dihe-na -80.44, 159.09 APE9-dihe-na -62.97, -36.0 APE8-dihe-in -102.05, 125.52 APE8-rot-in 305.35 APE67-dihe-inflip 117.81, -24.89 -71.98, 170.65 APE12-dist-in 10.0168 APE11-dist-out 6.4169 APE10-dist-in 7.0661 APE9-dist-out 8.7347 None None None XRAY 1.85 0.192 0.235 B 434.0 392.0 10 31 31 0 [[571, 832]] 1.0 7bmk OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6URCA O75460 560 963 977.0 QFV:1001 Type1.5_Back Inactive DFGin 7.1706 14.4305 BLAminus -137.78, -167.93 65.57, 72.79 -93.53, 16.27 296.4, 97.38 -65.24, -15.16 out-out out 10.0779 Saltbr-out 5.427 HRD-in -79.31, -54.62 74.23, 3.96 out-in-out SNCoio in-out ActLoopNT-in 2.8375 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -93.3, -9.99 APE9-dihe-na 149.54, -144.19 APE8-dihe-in -113.92, 127.41 APE8-rot-in 303.4 APE67-dihe-inflip 100.0, -7.56 -46.92, 125.76 APE12-dist-in 10.921 APE11-dist-out 7.2611 APE10-dist-out 9.666 APE9-dist-in 3.8013 None None None XRAY 2.2 0.223 0.274 A 434.0 400.0 0 31 31 0 [[571, 832]] 1.0 6urc OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6URCB O75460 560 963 977.0 QFV:1001 Type1.5_Back Inactive DFGin 7.0508 14.2247 BLAminus -133.22, -173.47 69.03, 75.97 -95.56, 16.52 300.55, 96.62 -60.7, -19.84 out-out out 10.0619 Saltbr-out 5.5802 HRD-in -76.52, -51.32 73.26, 7.62 out-in-out SNCoio in-out ActLoopNT-in 2.7292 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -86.29, -17.31 APE9-dihe-na 144.52, -148.41 APE8-dihe-in -105.98, 124.4 APE8-rot-in 298.12 APE67-dihe-inflip 103.6, -12.44 -49.39, 126.46 APE12-dist-in 10.8169 APE11-dist-out 7.0837 APE10-dist-out 9.909 APE9-dist-in 3.837 None None None XRAY 2.2 0.223 0.274 B 434.0 398.0 0 31 31 0 [[571, 832]] 1.0 6urc OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6XDDB O75460 560 963 977.0 N97:1001 Type1.5_Back Inactive DFGin 7.1088 14.5264 BLAminus -139.89, -179.2 70.17, 73.7 -98.79, 17.74 298.51, 86.41 -64.67, -28.57 in-out in 9.9623 Saltbr-out 5.494 HRD-in -74.08, -50.98 72.16, 2.0 out-in-in SNCoii in-in ActLoopNT-in 2.9257 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -71.87, 142.87 APE9-dihe-na 140.33, 179.07 APE8-dihe-in -119.71, 134.07 APE8-rot-in 305.81 APE67-dihe-inflip 102.26, -11.35 -53.88, 126.31 APE12-dist-in 10.9744 APE11-dist-in 10.707 APE10-dist-in 4.783 APE9-dist-in 3.4813 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.4 0.2 0.238 B 434.0 404.0 0 31 31 0 [[571, 832]] 1.0 6xdd OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 4U6RA O75460 561 963 977.0 3E4:1001 Type1.5_Back Inactive DFGin 7.0472 14.4094 BLAminus -137.98, -174.58 66.91, 71.23 -95.79, 12.94 302.54, 101.22 -59.26, -23.05 out-out out 10.6736 Saltbr-out 5.9737 HRD-in -69.95, -43.6 74.35, -6.96 out-in-out SNCoio in-out ActLoopNT-in 2.9933 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -85.62, 70.84 APE9-dihe-na 123.49, -154.22 APE8-dihe-in -117.41, 132.07 APE8-rot-in 301.36 APE67-dihe-inflip 102.11, -11.56 -49.68, 126.85 APE12-dist-in 11.0112 APE11-dist-in 10.2731 APE10-dist-out 8.4302 APE9-dist-in 3.4361 None None None XRAY 2.5 0.204 0.246 A 455.0 403.0 0 31 31 0 [[571, 832]] 1.0 4u6r OTHER_ERN1_HUMAN CAMK 3.9e-35 127.7 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6XDBA O75460 561 964 977.0 N8S:1001 Type1.5_Back Inactive DFGin 7.1334 14.329 BLAminus -132.32, -176.36 63.12, 79.47 -100.65, 32.62 307.21, 90.79 -67.25, -28.96 out-out out 10.4752 Saltbr-out 4.7949 HRD-in -83.13, -48.83 76.19, 2.79 out-in-out SNCoio in-out ActLoopNT-in 2.9515 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -66.73, -30.45 APE9-dihe-na 149.19, -146.33 APE8-dihe-in -109.5, 126.62 APE8-rot-in 302.1 APE67-dihe-inflip 92.9, -11.46 -58.42, 139.25 APE12-dist-in 7.0864 APE11-dist-out 6.8396 APE10-dist-out 9.7917 APE9-dist-in 3.979 None None None XRAY 2.45 0.195 0.227 A 434.0 404.0 0 31 31 0 [[571, 832]] 1.0 6xdb OTHER_ERN1_HUMAN CAMK 3.1e-34 124.7 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6W3EA O75460 562 962 977.0 SJV:1001 Type1.5_Front Inactive DFGin 5.5595 15.899 BLAminus -140.85, 172.03 60.0, 89.13 -100.99, 31.09 302.24, 167.69 86.31, 999.0 out-out out 10.5839 Saltbr-out 7.0561 HRD-out -78.48, 138.54 -121.69, -39.51 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 110.12, -20.7 999.0, 1.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.737 0.267 0.317 A 431.0 366.0 31 31 10 21 [[571, 832]] 1.0 6w3e OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6XDDA O75460 560 963 977.0 N97:1001 Type1.5_Front Inactive DFGin 5.4887 15.2052 BLAminus -139.2, -157.42 53.89, 65.22 -88.09, 16.93 282.86, 65.69 -65.77, -21.13 out-out out 11.1885 Saltbr-out 12.0422 HRD-in -80.68, -53.29 75.03, 2.35 out-in-out SNCoio in-out ActLoopNT-in 2.9111 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oiio APE10-dihe-na -59.07, 142.31 APE9-dihe-na -71.86, -26.93 APE8-dihe-in -99.41, 120.0 APE8-rot-in 319.4 APE67-dihe-out 115.13, -26.59 -99.28, -175.8 APE12-dist-out 6.004 APE11-dist-in 9.1143 APE10-dist-in 7.3471 APE9-dist-out 9.0162 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.4 0.2 0.238 A 434.0 404.0 0 31 31 0 [[571, 832]] 1.0 6xdd OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 8UVLA O75460 562 964 977.0 XOE:1009 Type1.5_Front Inactive DFGin 4.4993 14.81 BLAminus -137.56, -175.69 71.07, 82.79 -97.11, 15.73 276.96, 54.31 -66.64, -22.13 out-out out 12.0688 Saltbr-out 11.2688 HRD-in -84.52, -50.1 80.24, 0.69 out-in-out SNCoio in-out ActLoopNT-in 2.7989 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -65.36, -16.47 APE9-dihe-na 124.74, -153.73 APE8-dihe-in -111.02, 130.63 APE8-rot-in 288.72 APE67-dihe-inflip 102.08, -11.75 -58.44, 133.55 APE12-dist-in 7.7205 APE11-dist-out 7.1414 APE10-dist-out 10.0972 APE9-dist-in 3.8992 None None None XRAY 2.43 0.184 0.251 A 448.0 403.0 0 31 31 0 [[571, 832]] 1.0 8uvl OTHER_ERN1_HUMAN CAMK 3.3e-34 124.6 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 4YZDA O75460 563 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.1061 13.4537 BLBplus -141.52, 169.79 75.76, 4.13 -62.0, 156.83 53.76, 79.18 72.65, 35.33 out-out out 15.8851 Saltbr-out 13.4097 HRD-in -64.16, -47.27 74.91, -18.55 out-out-out SNCooo out-out ActLoopNT-out 10.5839 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -69.65, 158.55 APE9-dihe-na 98.62, 175.79 APE8-dihe-in -108.17, 135.68 APE8-rot-in 302.59 APE67-dihe-inflip 100.94, -24.59 -56.48, 129.95 APE12-dist-none 999.0 APE11-dist-in 13.4057 APE10-dist-out 8.1612 APE9-dist-in 3.4231 None None None XRAY 3.102 0.234 0.273 A 405.0 383.0 18 31 19 12 [[571, 832]] 1.0 4yzd OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 4YZDB O75460 563 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.2039 13.1793 BLBplus -141.12, 169.65 69.57, 15.58 -67.08, 155.42 48.06, 78.07 72.22, 36.23 out-out out 15.8795 Saltbr-out 13.1182 HRD-in -63.57, -45.81 74.7, -19.84 out-out-none SNCoon out-none ActLoopNT-out 10.5805 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -69.77, 158.99 APE9-dihe-na 99.89, 174.78 APE8-dihe-in -110.07, 134.42 APE8-rot-in 300.85 APE67-dihe-inflip 103.95, -24.75 -57.78, 133.16 APE12-dist-none 999.0 APE11-dist-in 12.6724 APE10-dist-in 7.5681 APE9-dist-in 3.5283 None None None XRAY 3.102 0.234 0.273 B 405.0 385.0 15 31 19 12 [[571, 832]] 1.0 4yzd OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 4YZDC O75460 563 964 977.0 ADP:1001 ATPlike Inactive DFGin 7.2921 13.5559 BLBplus -142.06, 170.34 76.33, 5.28 -64.41, 157.35 50.79, 79.33 73.41, 36.41 out-out out 16.1942 Saltbr-out 13.2528 HRD-in -63.95, -47.78 74.02, -20.41 out-out-none SNCoon out-none ActLoopNT-out 10.5812 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -70.78, 158.57 APE9-dihe-na 97.6, 174.43 APE8-dihe-in -111.17, 134.53 APE8-rot-in 303.43 APE67-dihe-inflip 103.93, -24.42 -56.8, 132.74 APE12-dist-none 999.0 APE11-dist-in 12.4096 APE10-dist-in 7.7835 APE9-dist-in 3.412 None None None XRAY 3.102 0.234 0.273 C 405.0 379.0 21 31 19 12 [[571, 832]] 1.0 4yzd OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 3P23A O75460 563 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.3396 13.7092 BLBplus -135.51, 176.11 64.76, 22.4 -82.8, 150.63 49.7, 79.84 86.4, 10.86 out-out out 16.0885 Saltbr-out 13.0695 HRD-in -67.24, -58.17 81.51, -4.45 out-out-out SNCooo out-out ActLoopNT-out 10.4016 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -84.29, 161.18 APE9-dihe-na 82.17, -162.33 APE8-dihe-in -132.44, 136.42 APE8-rot-in 302.1 APE67-dihe-inflip 108.83, 5.18 -54.01, 119.49 APE12-dist-none 999.0 APE11-dist-in 12.5576 APE10-dist-out 9.1227 APE9-dist-in 3.1961 None None None XRAY 2.7 0.238 0.294 A 432.0 386.0 15 31 19 12 [[571, 832]] 1.0 3p23 OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 3P23B O75460 564 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.4832 13.6464 BLBplus -139.9, 176.5 76.83, 14.87 -83.89, 150.35 55.49, 87.42 97.57, -33.78 out-out out 15.9363 Saltbr-out 12.6575 HRD-in -62.38, -39.7 42.05, 35.85 out-out-out SNCooo out-out ActLoopNT-out 9.7011 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 143.86 APE9-dihe-na -111.46, -135.27 APE8-dihe-in -106.96, 135.19 APE8-rot-in 295.43 APE67-dihe-inflip 111.53, -14.08 -51.84, 125.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.2132 APE9-dist-in 3.4766 None None None XRAY 2.7 0.238 0.294 B 432.0 386.0 15 31 19 12 [[571, 832]] 1.0 3p23 OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 3P23C O75460 561 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.5436 13.1728 BLBplus -149.53, -176.42 65.18, 18.98 -70.01, 144.07 39.63, 91.88 97.04, -114.33 out-out out 15.805 Saltbr-out 13.146 HRD-in -52.59, -55.72 76.18, 1.65 out-out-out SNCooo out-out ActLoopNT-out 11.1417 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioi APE10-dihe-na -53.61, -99.6 APE9-dihe-na -77.2, 171.08 APE8-dihe-in -47.05, 145.36 APE8-rot-in 345.28 APE67-dihe-out 116.59, -10.88 85.51, 60.96 APE12-dist-in 12.8381 APE11-dist-in 13.2434 APE10-dist-out 9.3534 APE9-dist-in 3.5072 None None None XRAY 2.7 0.238 0.294 C 432.0 390.0 14 31 20 11 [[571, 832]] 1.0 3p23 OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 3P23D O75460 561 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.4094 13.2631 BLBplus -138.88, 177.03 72.28, 10.83 -71.52, 154.68 50.97, 93.75 83.32, -17.5 out-out out 16.034 Saltbr-out 13.0181 HRD-in -58.06, -54.76 77.4, -2.34 out-out-out SNCooo out-out ActLoopNT-out 10.0574 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnoi APE10-dihe-na 999.0, 162.88 APE9-dihe-na -149.96, -140.99 APE8-dihe-in -73.3, 139.85 APE8-rot-in 325.01 APE67-dihe-out 115.82, -9.19 91.28, 60.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.1125 APE9-dist-in 4.0378 None None None XRAY 2.7 0.238 0.294 D 432.0 387.0 16 31 17 14 [[571, 832]] 1.0 3p23 OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 9N88A O75460 563 964 977.0 No_ligand No_ligand Inactive DFGin 4.4954 14.3964 BLBplus -125.12, 173.56 61.62, 32.01 -93.6, 167.16 52.37, 88.56 65.58, 27.08 in-in in 8.4049 Saltbr-in 2.935 HRD-in -63.01, -46.54 69.36, -1.22 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 159.47 APE9-dihe-na 82.39, -50.55 APE8-dihe-in -47.73, 127.95 APE8-rot-in 291.31 APE67-dihe-inflip 89.37, 13.1 -79.77, 123.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.4321 APE9-dist-out 7.9773 None None None EM 2.6 999.0 999.0 A 402.0 379.0 23 31 15 16 [[571, 832]] 1.0 9n88 OTHER_ERN1_HUMAN CAMK 2.7e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 9N88E O75460 563 964 977.0 No_ligand No_ligand Inactive DFGin 4.4956 14.3957 BLBplus -125.13, 173.55 61.65, 32.03 -93.6, 167.11 52.36, 88.6 65.62, 27.08 in-in in 8.4049 Saltbr-in 2.9357 HRD-in -63.0, -46.58 69.41, -1.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 159.45 APE9-dihe-na 82.42, -50.53 APE8-dihe-in -47.73, 127.97 APE8-rot-in 291.31 APE67-dihe-inflip 89.32, 13.1 -79.8, 123.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.4328 APE9-dist-out 7.9774 None None None EM 2.6 999.0 999.0 E 402.0 379.0 23 31 15 16 [[571, 832]] 1.0 9n88 OTHER_ERN1_HUMAN CAMK 2.7e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6W39A O75460 563 963 977.0 SJG:1001 Type1 Inactive DFGin 4.5887 14.5691 BLBplus -139.66, 174.98 64.22, 28.56 -90.96, 160.06 48.25, 86.99 74.2, -3.07 in-in in 8.8536 Saltbr-in 2.8681 HRD-in -66.64, -55.32 82.3, -19.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 171.9 APE8-rot-out 195.33 APE67-dihe-out 108.3, -8.16 -110.65, -131.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.736 0.197 0.235 A 431.0 374.0 24 31 12 19 [[571, 832]] 1.0 6w39 OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6W39B O75460 563 963 977.0 SJG:1001 Type1 Inactive DFGin 4.6099 14.5377 BLBplus -144.1, 177.6 64.91, 27.62 -88.82, 154.64 46.85, 89.19 64.91, 16.36 in-in in 8.5816 Saltbr-in 3.5167 HRD-in -72.2, -52.15 80.89, -14.52 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -179.25 APE8-rot-out 67.26 APE67-dihe-out 104.99, -2.33 -121.34, -117.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.736 0.197 0.235 B 431.0 374.0 25 31 12 19 [[571, 832]] 1.0 6w39 OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6W3AA O75460 562 964 977.0 SJM:1001 Type1 Inactive DFGin 4.6873 14.7501 BLBplus -159.03, 176.32 57.32, 40.69 -104.35, 145.33 50.26, 89.45 73.99, 38.41 in-in in 8.7186 Saltbr-in 2.9408 HRD-in -70.5, -44.05 68.58, -4.98 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 107.79 APE8-dihe-out -141.14, -179.39 APE8-rot-out 65.3 APE67-dihe-out 122.02, -15.91 -119.08, -128.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.5774 None None None XRAY 2.606 0.249 0.29 A 434.0 363.0 32 31 13 18 [[571, 832]] 1.0 6w3a OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6W3AB O75460 562 964 977.0 SJM:1001 Type1 Inactive DFGin 4.4445 14.5841 BLBplus -150.2, 175.33 54.85, 42.0 -103.74, 137.1 52.82, 87.58 88.2, 19.62 in-out in 8.5425 Saltbr-out 3.6453 HRD-in -69.7, -38.0 68.52, -8.14 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 121.7 APE8-dihe-out -126.01, -171.29 APE8-rot-out 66.29 APE67-dihe-out 116.07, -16.83 -111.97, -139.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.6537 None None None XRAY 2.606 0.249 0.29 B 434.0 371.0 25 31 14 17 [[571, 832]] 1.0 6w3a OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 4Z7GA O75460 562 963 977.0 No_ligand No_ligand Inactive DFGin 4.9957 14.5333 None -140.81, 175.34 43.48, 101.03 -87.72, 999.0 308.92, 94.22 999.0, 999.0 in-in in 8.9466 Saltbr-in 2.8404 HRD-in -60.57, -47.56 72.24, -10.39 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, -18.99 APE9-dihe-na -167.3, -173.38 APE8-dihe-in -130.49, 124.62 APE8-rot-out 52.96 APE67-dihe-inflip 106.42, -11.92 -35.23, 118.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.8338 None None None XRAY 2.6 0.204 0.226 A 416.0 366.0 26 31 12 19 [[571, 832]] 1.0 4z7g OTHER_ERN1_HUMAN CAMK 3e-35 128.0 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 4Z7GB O75460 562 962 977.0 No_ligand No_ligand Inactive DFGin 4.9099 14.386 None -141.89, 174.99 45.35, 92.04 -84.88, 999.0 313.4, 110.77 999.0, 999.0 in-in in 8.916 Saltbr-in 2.8322 HRD-in -60.96, -47.53 72.73, -11.47 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na -63.92, -20.1 APE9-dihe-na -168.1, 175.6 APE8-dihe-in -122.17, 125.73 APE8-rot-out 53.21 APE67-dihe-inflip 110.25, -18.1 -36.38, 118.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.8352 None None None XRAY 2.6 0.204 0.226 B 416.0 377.0 24 31 13 18 [[571, 832]] 1.0 4z7g OTHER_ERN1_HUMAN CAMK 3e-35 128.0 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 4Z7HA O75460 562 963 977.0 4L5:1001 Type1 Inactive DFGin 5.3928 14.9773 None -138.87, -45.43 -76.98, 88.77 -83.95, 3.75 273.49, 77.38 -61.03, -41.59 in-in in 8.8506 Saltbr-in 2.8087 HRD-in -73.17, -46.77 63.73, 3.56 in-in-out SNCiio in-out ActLoopNT-in 2.9283 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, -6.85 APE9-dihe-na 151.6, -155.97 APE8-dihe-in -123.5, 123.79 APE8-rot-out 45.5 APE67-dihe-inflip 106.26, -20.23 -56.36, 141.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.6127 APE9-dist-in 4.6464 None None None XRAY 2.9 0.202 0.225 A 416.0 385.0 10 31 26 5 [[571, 832]] 1.0 4z7h OTHER_ERN1_HUMAN CAMK 3e-35 128.0 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 4YZ9A O75460 562 964 977.0 4K7:1001 Type3 Inactive DFGout 15.9304 7.2574 None -145.42, 154.32 -79.25, -25.27 -113.1, 147.21 74.93, 92.08 -101.05, 170.75 out-out out 11.465 Saltbr-out 6.557 HRD-in -65.78, -56.93 75.18, -20.46 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 65.49 APE8-dihe-out -91.72, -3.5 APE8-rot-out 69.34 APE67-dihe-inflip 101.89, 14.03 -97.24, 145.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.7819 None None None XRAY 2.463 0.238 0.283 A 405.0 381.0 22 31 14 17 [[571, 832]] 1.0 4yz9 OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 4YZ9B O75460 563 963 977.0 4K7:1001 Type3 Inactive DFGout 17.0401 7.2662 None -150.4, 164.44 -74.79, -40.79 -115.62, 154.13 77.21, 107.48 -102.62, 170.51 out-out out 12.3592 Saltbr-out 7.6157 HRD-in -70.74, -51.1 76.22, -19.19 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 103.24, -20.76 999.0, -159.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.463 0.238 0.283 B 405.0 375.0 24 31 12 19 [[571, 832]] 1.0 4yz9 OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 4YZ9C O75460 562 964 977.0 4K7:1001 Type3 Inactive DFGout 15.914 7.1097 None -135.14, 175.91 -93.49, -10.88 -129.03, 149.22 68.81, 88.89 -96.28, -179.45 out-out out 11.562 Saltbr-out 6.7491 HRD-in -69.18, -49.88 66.0, -15.77 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -33.06 APE8-rot-in 308.85 APE67-dihe-inflip 96.07, 16.76 -122.57, 162.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.463 0.238 0.283 C 405.0 378.0 25 31 13 18 [[571, 832]] 1.0 4yz9 OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6HX1A O75460 562 964 977.0 GXK:1001 Type1 Inactive None 999.0 9.0308 None -117.25, 153.54 -78.62, -34.04 -91.96, 133.47 286.33, 72.45 -93.93, 146.96 none-none none 999.0 Saltbr-none 999.0 HRD-in -64.4, -55.14 79.73, -2.12 none-out-out SNCnoo out-out ActLoopNT-out 22.4776 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -51.71, 130.91 APE9-dihe-na 103.58, -28.73 APE8-dihe-out -114.51, 37.72 APE8-rot-out 76.32 APE67-dihe-in -78.77, 3.79 -81.24, -41.88 APE12-dist-in 12.3412 APE11-dist-in 9.3784 APE10-dist-out 11.3233 APE9-dist-out 15.6953 None None None XRAY 2.14 0.219 0.268 A 403.0 387.0 16 31 29 2 [[571, 832]] 1.0 6hx1 OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6HV0A O75460 562 963 977.0 GUK:1001 Type1 Inactive None 999.0 9.1821 None -133.1, 153.75 -66.3, -48.4 -89.37, 135.79 292.63, 70.49 -93.67, 142.5 none-none none 999.0 Saltbr-none 999.0 HRD-in -70.37, -40.56 70.66, -13.49 none-out-out SNCnoo out-out ActLoopNT-out 22.5117 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -88.59, 128.96 APE9-dihe-na -116.2, 97.18 APE8-dihe-out -118.13, -15.29 APE8-rot-in 276.8 APE67-dihe-inflip 101.83, -26.03 -49.76, 144.64 APE12-dist-in 12.836 APE11-dist-in 10.0861 APE10-dist-out 11.6617 APE9-dist-out 15.7445 None None None XRAY 2.73 0.217 0.269 A 416.0 377.0 23 31 31 0 [[571, 832]] 1.0 6hv0 OTHER_ERN1_HUMAN CAMK 3e-35 128.0 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 4YZCA O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.5402 13.5982 BLAminus -149.66, -173.45 57.49, 66.53 -77.65, -2.16 287.89, 65.87 -48.01, -38.7 in-none in 9.3632 Saltbr-none 999.0 HRD-in -69.99, -44.37 70.23, -12.54 none-in-in SNCnii in-in ActLoopNT-in 2.8966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -68.95, 160.8 APE9-dihe-na 106.7, 168.85 APE8-dihe-in -105.56, 142.33 APE8-rot-in 309.63 APE67-dihe-inflip 90.78, -21.58 -55.3, 131.97 APE12-dist-in 10.4006 APE11-dist-in 11.3276 APE10-dist-in 5.4058 APE9-dist-in 3.6014 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 A 405.0 385.0 17 31 30 1 [[571, 832]] 1.0 4yzc OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 4YZCB O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.3622 13.613 BLAminus -140.88, -173.22 59.3, 72.64 -84.99, 5.45 286.37, 62.28 -53.44, -38.69 in-none in 9.6084 Saltbr-none 999.0 HRD-in -70.83, -44.64 74.46, -16.49 none-in-in SNCnii in-in ActLoopNT-in 2.9715 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -78.48, 164.52 APE9-dihe-na 106.87, 177.31 APE8-dihe-in -111.04, 139.81 APE8-rot-in 310.36 APE67-dihe-inflip 90.66, -20.76 -52.98, 131.15 APE12-dist-in 10.8362 APE11-dist-in 11.2328 APE10-dist-in 5.3941 APE9-dist-in 3.6931 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 B 405.0 384.0 18 31 29 2 [[571, 832]] 1.0 4yzc OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 6W3KA O75460 562 963 977.0 SJS:1001 Type1 None DFGin 5.733 14.4855 BLAminus -136.61, -178.37 67.07, 78.89 -100.93, 17.07 281.07, 41.19 -67.11, -27.01 in-in in 8.2042 Saltbr-in 2.756 HRD-in -74.42, -52.27 75.94, 0.0 in-in-none SNCiin in-none ActLoopNT-in 2.8974 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 69.85 APE9-dihe-na 125.22, -177.52 APE8-dihe-in -111.61, 120.85 APE8-rot-in 306.38 APE67-dihe-inflip 105.25, -16.79 -50.22, 133.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.7294 APE9-dist-in 3.9769 None None None XRAY 2.08 0.192 0.217 A 434.0 398.0 4 31 27 4 [[571, 832]] 1.0 6w3k OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1

OTHER_ERN1 (Serine/threonine-protein kinase/endoribonuclease IRE1)

Total number of chains: 60
Active chains: 8
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 28 46.7% AF-O75460-K1A
DFGin BLBplus 23 38.3% 3P23C
DFGin None 3 5.0% 4Z7HA
DFGout None 3 5.0% 4YZ9A
None None 2 3.3% 6HX1A
DFGin ABAminus 1 1.7% 4Z7HB

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ERN1 ERN1_HUMAN AF-O75460-K1A O75460 561 840 977.0 No_ligand No_ligand Active DFGin 5.2263 14.3584 BLAminus -136.1, 174.69 62.75, 82.9 -90.11, 8.09 278.92, 58.01 -56.59, -35.42 in-in in 8.6229 Saltbr-in 2.7387 HRD-in -70.55, -49.28 65.1, -0.16 in-in-in SNCiii in-in ActLoopNT-in 2.8855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.61, 153.38 APE9-dihe-na 118.83, 174.73 APE8-dihe-in -98.29, 131.32 APE8-rot-in 303.59 APE67-dihe-inflip 83.09, -9.62 -47.44, 134.97 APE12-dist-in 10.8728 APE11-dist-in 11.1467 APE10-dist-in 5.2379 APE9-dist-in 3.29 None None None AF2 -1.0 1.0 1.0 A 280.0 280.0 0 31 31 0 [[571, 832]] 1.0 AF-O75460-K1 Homo sapiens OTHER_ERN1_HUMAN CAMK 8.3e-36 129.6 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN AF-O75460-K3A O75460 561 840 977.0 No_ligand No_ligand Active DFGin 5.2492 14.1487 BLAminus -135.31, -174.96 58.8, 76.05 -86.75, 1.33 278.92, 66.56 -57.5, -35.04 in-in in 8.4609 Saltbr-in 2.6786 HRD-in -73.71, -47.28 67.17, -7.9 in-in-in SNCiii in-in ActLoopNT-in 2.7771 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -67.31, 152.38 APE9-dihe-na 117.01, 175.14 APE8-dihe-in -93.16, 133.21 APE8-rot-in 303.49 APE67-dihe-inflip 79.17, -0.04 -48.5, 133.79 APE12-dist-in 10.8937 APE11-dist-in 11.1975 APE10-dist-in 5.3029 APE9-dist-in 3.4198 None None None AF2 -1.0 1.0 1.0 A 280.0 280.0 0 31 31 0 [[571, 832]] 1.0 AF-O75460-K3 Homo sapiens OTHER_ERN1_HUMAN CAMK 8.3e-36 129.6 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6W3CA O75460 560 964 977.0 No_ligand No_ligand Active DFGin 6.1058 14.2357 BLAminus -143.3, -169.77 61.92, 75.26 -99.59, 5.17 293.74, 80.96 -57.56, -26.8 in-in in 8.19 Saltbr-in 2.4383 HRD-in -73.83, -48.09 71.71, -9.73 in-in-in SNCiii in-in ActLoopNT-in 2.8021 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -71.3, -33.45 APE9-dihe-na -62.43, 169.01 APE8-dihe-in -93.38, 133.53 APE8-rot-in 300.11 APE67-dihe-inflip 106.95, -8.39 -49.76, 124.1 APE12-dist-in 11.2447 APE11-dist-in 11.3955 APE10-dist-in 5.4301 APE9-dist-in 3.4493 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.3 0.208 0.248 A 434.0 405.0 0 31 31 0 [[571, 832]] 1.0 6w3c Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6W3CB O75460 560 963 977.0 No_ligand No_ligand Active DFGin 6.1058 14.899 BLAminus -154.48, -168.03 55.85, 78.98 -100.05, 13.54 285.56, 16.26 -60.83, -29.52 in-in in 8.3655 Saltbr-in 2.6337 HRD-in -75.16, -45.21 69.8, 0.87 in-in-in SNCiii in-in ActLoopNT-in 2.7083 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -79.23, 157.93 APE9-dihe-na 117.83, 146.57 APE8-dihe-in -81.19, 135.69 APE8-rot-in 308.77 APE67-dihe-inflip 111.32, -6.95 -54.24, 124.62 APE12-dist-in 10.8874 APE11-dist-in 10.8973 APE10-dist-in 4.9571 APE9-dist-in 3.5412 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.3 0.208 0.248 B 434.0 404.0 0 31 31 0 [[571, 832]] 1.0 6w3c Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6W3CC O75460 560 963 977.0 No_ligand No_ligand Active DFGin 5.657 15.0187 BLAminus -147.84, -172.12 60.8, 76.5 -95.31, 10.61 280.4, 53.86 -59.0, -26.79 in-in in 8.706 Saltbr-in 2.7208 HRD-in -80.88, -50.26 69.52, 4.83 in-in-in SNCiii in-in ActLoopNT-in 2.9577 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -79.43, 153.53 APE9-dihe-na 125.25, 174.09 APE8-dihe-in -105.72, 131.11 APE8-rot-in 300.67 APE67-dihe-inflip 110.66, -4.8 -51.94, 122.81 APE12-dist-in 11.2388 APE11-dist-in 11.1201 APE10-dist-in 5.2179 APE9-dist-in 3.6747 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.3 0.208 0.248 C 434.0 404.0 0 31 31 0 [[571, 832]] 1.0 6w3c Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6W3CD O75460 560 963 977.0 No_ligand No_ligand Active DFGin 5.9323 15.058 BLAminus -157.54, -163.82 60.31, 71.97 -98.14, 3.34 281.98, 17.28 -56.04, -29.73 in-in in 8.6424 Saltbr-in 2.7148 HRD-in -75.91, -46.58 71.49, -6.58 in-in-in SNCiii in-in ActLoopNT-in 2.71 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -80.66, -18.6 APE9-dihe-na -64.06, 167.42 APE8-dihe-in -92.49, 134.25 APE8-rot-in 304.43 APE67-dihe-inflip 103.66, -4.02 -51.74, 125.98 APE12-dist-in 11.3016 APE11-dist-in 11.2182 APE10-dist-in 5.2576 APE9-dist-in 3.4824 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.3 0.208 0.248 D 434.0 404.0 0 31 31 0 [[571, 832]] 1.0 6w3c Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 9GOWA O75460 562 964 977.0 A1IOO:1001 Type1 Active DFGin 5.7525 15.8477 BLAminus -137.11, -164.14 55.29, 61.49 -82.92, 7.86 279.34, 27.53 -61.24, -35.15 in-in in 9.2808 Saltbr-in 3.2173 HRD-in -66.48, -56.29 77.33, -1.62 in-in-in SNCiii in-in ActLoopNT-in 2.9617 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -75.9, 139.91 APE9-dihe-na 137.0, 174.42 APE8-dihe-in -105.74, 137.36 APE8-rot-in 313.93 APE67-dihe-inflip 116.47, -18.45 -55.17, 118.89 APE12-dist-in 10.6547 APE11-dist-in 11.2725 APE10-dist-in 5.2365 APE9-dist-in 3.6305 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 3.0 0.234 0.281 A 434.0 403.0 0 31 31 0 [[571, 832]] 1.0 9gow Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 9GOWC O75460 562 964 977.0 A1IOO:1001 Type1 Active DFGin 5.6346 15.5587 BLAminus -132.52, 179.7 73.16, 53.18 -77.31, 13.24 285.48, 55.31 -73.1, -19.29 in-in in 9.0393 Saltbr-in 3.0186 HRD-in -82.58, -51.91 71.45, 18.84 in-in-in SNCiii in-in ActLoopNT-in 2.6297 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -81.81, 130.02 APE9-dihe-na 148.27, 178.17 APE8-dihe-in -119.07, 134.7 APE8-rot-in 323.09 APE67-dihe-inflip 99.28, -15.5 -52.59, 133.44 APE12-dist-in 10.7733 APE11-dist-in 11.2227 APE10-dist-in 5.3477 APE9-dist-in 3.6646 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 3.0 0.234 0.281 C 434.0 403.0 0 31 31 0 [[571, 832]] 1.0 9gow Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 4Z7HB O75460 562 962 977.0 4L5:1001 Type1 Inactive DFGin 5.1351 14.5181 ABAminus -147.31, -25.96 -101.01, 93.63 -84.21, 0.58 280.19, 77.98 -61.73, -35.98 in-in in 8.2947 Saltbr-in 2.8804 HRD-in -73.65, -45.51 64.99, 2.13 in-in-out SNCiio in-out ActLoopNT-in 2.9362 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioi APE10-dihe-na -82.39, -0.49 APE9-dihe-na 151.41, -152.92 APE8-dihe-in -124.62, 124.86 APE8-rot-out 45.76 APE67-dihe-inflip 103.66, -22.96 -54.37, 143.35 APE12-dist-none 999.0 APE11-dist-in 8.4359 APE10-dist-out 8.7362 APE9-dist-in 4.695 None None None XRAY 2.9 0.202 0.225 B 416.0 388.0 13 31 24 7 [[571, 832]] 1.0 4z7h Homo sapiens OTHER_ERN1_HUMAN CAMK 3e-35 128.0 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 5HGIA O75460 562 964 977.0 No_ligand No_ligand Inactive DFGin 5.6094 14.6427 BLAminus -145.05, -173.6 59.23, 77.97 -93.33, 15.89 299.4, 90.09 -56.25, -41.67 in-in in 8.8345 Saltbr-in 3.0851 HRD-in -70.44, -52.16 82.22, -6.2 in-in-out SNCiio in-out ActLoopNT-in 2.8046 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -73.82, 158.67 APE9-dihe-na -55.87, 177.33 APE8-dihe-in -86.18, 152.71 APE8-rot-in 291.18 APE67-dihe-inflip 109.66, -27.51 -52.0, 151.26 APE12-dist-in 7.7156 APE11-dist-out 6.8495 APE10-dist-out 9.2179 APE9-dist-in 4.3624 None None None XRAY 2.584 0.214 0.247 A 431.0 395.0 5 31 31 0 [[571, 832]] 1.0 5hgi Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6XDFB O75460 562 964 977.0 No_ligand No_ligand Inactive DFGin 5.7339 14.8635 BLAminus -147.47, -177.07 57.93, 76.76 -96.5, 15.93 283.55, 47.82 -59.81, -43.08 in-in in 8.2284 Saltbr-in 2.7368 HRD-in -73.76, -49.3 76.45, -0.87 in-in-out SNCiio in-out ActLoopNT-in 2.876 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnio APE10-dihe-na 999.0, -169.01 APE9-dihe-na 101.44, -83.65 APE8-dihe-in -134.49, 143.31 APE8-rot-in 313.33 APE67-dihe-inflip 129.9, -41.41 -81.7, 159.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.524 APE9-dist-out 7.4378 None None None XRAY 2.54 0.209 0.263 B 431.0 400.0 3 31 29 2 [[571, 832]] 1.0 6xdf Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6W3BA O75460 562 963 977.0 No_ligand No_ligand Inactive DFGin 5.2814 15.0145 BLAminus -143.27, -170.93 56.51, 82.48 -97.69, 18.76 283.82, 27.48 -70.15, -29.01 in-in in 9.0168 Saltbr-in 3.226 HRD-in -67.85, -45.67 72.89, 0.99 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -72.27, -21.84 APE9-dihe-na 147.89, -147.39 APE8-dihe-in -108.47, 126.95 APE8-rot-in 297.0 APE67-dihe-inflip 99.73, -10.05 -56.76, 133.68 APE12-dist-in 7.5063 APE11-dist-out 7.5768 APE10-dist-out 10.0403 APE9-dist-in 4.0185 None None None XRAY 2.57 0.206 0.246 A 434.0 398.0 0 31 31 0 [[571, 832]] 1.0 6w3b Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 9GOWB O75460 562 964 977.0 A1IOO:1001 Type1 Inactive DFGin 5.6591 15.5949 BLAminus -145.27, -164.83 46.92, 70.18 -87.21, 11.29 280.69, 69.55 -62.43, -36.43 in-in in 9.514 Saltbr-in 2.9159 HRD-in -81.2, -46.9 74.25, -11.86 in-in-out SNCiio in-out ActLoopNT-in 2.9113 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -59.45, 144.76 APE9-dihe-na 126.14, -167.15 APE8-dihe-in -135.75, 140.85 APE8-rot-out 210.8 APE67-dihe-inflip 99.64, -22.14 -57.98, 140.11 APE12-dist-in 10.8024 APE11-dist-in 11.1995 APE10-dist-in 5.274 APE9-dist-in 3.5398 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 3.0 0.234 0.281 B 434.0 403.0 0 31 31 0 [[571, 832]] 1.0 9gow Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 9GOWD O75460 562 964 977.0 A1IOO:1001 Type1 Inactive DFGin 5.8771 15.9408 BLAminus -144.08, -162.9 48.88, 78.62 -99.04, 18.45 261.61, 69.28 -69.53, -42.63 in-out in 9.4744 Saltbr-out 3.6973 HRD-in -82.34, -51.42 71.84, 19.12 out-in-out SNCoio in-out ActLoopNT-in 2.8911 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -60.38, 141.0 APE9-dihe-na 147.72, -174.34 APE8-dihe-in -119.1, 140.61 APE8-rot-out 31.47 APE67-dihe-inflip 82.22, -18.82 -56.96, 151.1 APE12-dist-in 10.9652 APE11-dist-in 11.5215 APE10-dist-in 5.4482 APE9-dist-in 3.9357 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 3.0 0.234 0.281 D 434.0 303.0 2 31 31 0 [[571, 832]] 1.0 9gow Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6W3EB O75460 563 963 977.0 SJV:1001 Type1.5_Back Inactive DFGin 5.7951 15.5172 BLAminus -141.88, 176.99 63.2, 84.04 -105.56, 28.54 300.08, 169.13 -67.07, -42.47 out-out out 10.1071 Saltbr-out 5.7074 HRD-out -80.93, 139.0 -122.23, -35.4 out-in-out SNCoio in-out ActLoopNT-in 2.9439 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -5.99 APE9-dihe-na -74.91, 153.53 APE8-dihe-out 63.33, 175.78 APE8-rot-out 67.1 APE67-dihe-inflip 108.9, -22.83 -150.99, 138.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.1462 APE9-dist-out 6.983 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.737 0.267 0.317 B 431.0 389.0 12 31 27 4 [[571, 832]] 1.0 6w3e Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6XDFA O75460 560 966 977.0 N94:1002 Type1.5_Back Inactive DFGin 6.3826 15.1993 BLAminus -130.29, -176.4 60.9, 76.83 -90.68, 29.29 294.67, 76.62 -70.73, -33.39 out-out out 10.1564 Saltbr-out 5.0934 HRD-in -82.04, -48.49 78.58, -9.6 out-in-out SNCoio in-out ActLoopNT-in 3.0092 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -73.17, -32.0 APE9-dihe-na 161.12, -145.76 APE8-dihe-in -111.23, 117.63 APE8-rot-in 300.24 APE67-dihe-inflip 110.41, -26.97 -49.33, 126.92 APE12-dist-in 7.6298 APE11-dist-out 6.918 APE10-dist-out 9.7984 APE9-dist-in 3.8602 None None None XRAY 2.54 0.209 0.263 A 431.0 402.0 5 31 31 0 [[571, 832]] 1.0 6xdf Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 7BMKA O75460 561 966 977.0 U4N:1001 Type1.5_Back Inactive DFGin 5.3046 15.6038 BLAminus -134.78, 175.72 71.56, 88.08 -95.42, 16.11 280.14, 64.53 -63.54, -33.93 out-out out 10.6201 Saltbr-out 5.4292 HRD-in -79.03, -50.32 75.82, -1.9 out-in-out SNCoio in-out ActLoopNT-in 2.8637 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -71.86, -22.99 APE9-dihe-na 146.38, -151.63 APE8-dihe-in -103.7, 128.54 APE8-rot-in 300.23 APE67-dihe-inflip 91.08, -11.6 -49.87, 131.36 APE12-dist-in 7.4825 APE11-dist-out 7.0097 APE10-dist-out 9.895 APE9-dist-in 3.7159 None None None XRAY 1.85 0.192 0.235 A 434.0 406.0 0 31 31 0 [[571, 832]] 1.0 7bmk Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 7BMKB O75460 562 963 977.0 U4N:1001 Type1.5_Back Inactive DFGin 5.4699 15.5574 BLAminus -136.75, 176.32 69.57, 85.31 -94.6, 15.21 280.65, 62.8 -61.14, -35.65 out-out out 10.4246 Saltbr-out 5.2954 HRD-in -76.97, -51.76 73.84, 1.59 out-in-out SNCoio in-out ActLoopNT-in 2.8504 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioio APE10-dihe-na -80.44, 159.09 APE9-dihe-na -62.97, -36.0 APE8-dihe-in -102.05, 125.52 APE8-rot-in 305.35 APE67-dihe-inflip 117.81, -24.89 -71.98, 170.65 APE12-dist-in 10.0168 APE11-dist-out 6.4169 APE10-dist-in 7.0661 APE9-dist-out 8.7347 None None None XRAY 1.85 0.192 0.235 B 434.0 392.0 10 31 31 0 [[571, 832]] 1.0 7bmk Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6URCA O75460 560 963 977.0 QFV:1001 Type1.5_Back Inactive DFGin 7.1706 14.4305 BLAminus -137.78, -167.93 65.57, 72.79 -93.53, 16.27 296.4, 97.38 -65.24, -15.16 out-out out 10.0779 Saltbr-out 5.427 HRD-in -79.31, -54.62 74.23, 3.96 out-in-out SNCoio in-out ActLoopNT-in 2.8375 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -93.3, -9.99 APE9-dihe-na 149.54, -144.19 APE8-dihe-in -113.92, 127.41 APE8-rot-in 303.4 APE67-dihe-inflip 100.0, -7.56 -46.92, 125.76 APE12-dist-in 10.921 APE11-dist-out 7.2611 APE10-dist-out 9.666 APE9-dist-in 3.8013 None None None XRAY 2.2 0.223 0.274 A 434.0 400.0 0 31 31 0 [[571, 832]] 1.0 6urc Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6URCB O75460 560 963 977.0 QFV:1001 Type1.5_Back Inactive DFGin 7.0508 14.2247 BLAminus -133.22, -173.47 69.03, 75.97 -95.56, 16.52 300.55, 96.62 -60.7, -19.84 out-out out 10.0619 Saltbr-out 5.5802 HRD-in -76.52, -51.32 73.26, 7.62 out-in-out SNCoio in-out ActLoopNT-in 2.7292 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -86.29, -17.31 APE9-dihe-na 144.52, -148.41 APE8-dihe-in -105.98, 124.4 APE8-rot-in 298.12 APE67-dihe-inflip 103.6, -12.44 -49.39, 126.46 APE12-dist-in 10.8169 APE11-dist-out 7.0837 APE10-dist-out 9.909 APE9-dist-in 3.837 None None None XRAY 2.2 0.223 0.274 B 434.0 398.0 0 31 31 0 [[571, 832]] 1.0 6urc Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6XDDB O75460 560 963 977.0 N97:1001 Type1.5_Back Inactive DFGin 7.1088 14.5264 BLAminus -139.89, -179.2 70.17, 73.7 -98.79, 17.74 298.51, 86.41 -64.67, -28.57 in-out in 9.9623 Saltbr-out 5.494 HRD-in -74.08, -50.98 72.16, 2.0 out-in-in SNCoii in-in ActLoopNT-in 2.9257 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -71.87, 142.87 APE9-dihe-na 140.33, 179.07 APE8-dihe-in -119.71, 134.07 APE8-rot-in 305.81 APE67-dihe-inflip 102.26, -11.35 -53.88, 126.31 APE12-dist-in 10.9744 APE11-dist-in 10.707 APE10-dist-in 4.783 APE9-dist-in 3.4813 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.4 0.2 0.238 B 434.0 404.0 0 31 31 0 [[571, 832]] 1.0 6xdd Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 4U6RA O75460 561 963 977.0 3E4:1001 Type1.5_Back Inactive DFGin 7.0472 14.4094 BLAminus -137.98, -174.58 66.91, 71.23 -95.79, 12.94 302.54, 101.22 -59.26, -23.05 out-out out 10.6736 Saltbr-out 5.9737 HRD-in -69.95, -43.6 74.35, -6.96 out-in-out SNCoio in-out ActLoopNT-in 2.9933 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -85.62, 70.84 APE9-dihe-na 123.49, -154.22 APE8-dihe-in -117.41, 132.07 APE8-rot-in 301.36 APE67-dihe-inflip 102.11, -11.56 -49.68, 126.85 APE12-dist-in 11.0112 APE11-dist-in 10.2731 APE10-dist-out 8.4302 APE9-dist-in 3.4361 None None None XRAY 2.5 0.204 0.246 A 455.0 403.0 0 31 31 0 [[571, 832]] 1.0 4u6r Homo sapiens OTHER_ERN1_HUMAN CAMK 3.9e-35 127.7 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6XDBA O75460 561 964 977.0 N8S:1001 Type1.5_Back Inactive DFGin 7.1334 14.329 BLAminus -132.32, -176.36 63.12, 79.47 -100.65, 32.62 307.21, 90.79 -67.25, -28.96 out-out out 10.4752 Saltbr-out 4.7949 HRD-in -83.13, -48.83 76.19, 2.79 out-in-out SNCoio in-out ActLoopNT-in 2.9515 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -66.73, -30.45 APE9-dihe-na 149.19, -146.33 APE8-dihe-in -109.5, 126.62 APE8-rot-in 302.1 APE67-dihe-inflip 92.9, -11.46 -58.42, 139.25 APE12-dist-in 7.0864 APE11-dist-out 6.8396 APE10-dist-out 9.7917 APE9-dist-in 3.979 None None None XRAY 2.45 0.195 0.227 A 434.0 404.0 0 31 31 0 [[571, 832]] 1.0 6xdb Homo sapiens OTHER_ERN1_HUMAN CAMK 3.1e-34 124.7 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6W3EA O75460 562 962 977.0 SJV:1001 Type1.5_Front Inactive DFGin 5.5595 15.899 BLAminus -140.85, 172.03 60.0, 89.13 -100.99, 31.09 302.24, 167.69 86.31, 999.0 out-out out 10.5839 Saltbr-out 7.0561 HRD-out -78.48, 138.54 -121.69, -39.51 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 110.12, -20.7 999.0, 1.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.737 0.267 0.317 A 431.0 366.0 31 31 10 21 [[571, 832]] 1.0 6w3e Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6XDDA O75460 560 963 977.0 N97:1001 Type1.5_Front Inactive DFGin 5.4887 15.2052 BLAminus -139.2, -157.42 53.89, 65.22 -88.09, 16.93 282.86, 65.69 -65.77, -21.13 out-out out 11.1885 Saltbr-out 12.0422 HRD-in -80.68, -53.29 75.03, 2.35 out-in-out SNCoio in-out ActLoopNT-in 2.9111 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oiio APE10-dihe-na -59.07, 142.31 APE9-dihe-na -71.86, -26.93 APE8-dihe-in -99.41, 120.0 APE8-rot-in 319.4 APE67-dihe-out 115.13, -26.59 -99.28, -175.8 APE12-dist-out 6.004 APE11-dist-in 9.1143 APE10-dist-in 7.3471 APE9-dist-out 9.0162 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.4 0.2 0.238 A 434.0 404.0 0 31 31 0 [[571, 832]] 1.0 6xdd Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 8UVLA O75460 562 964 977.0 XOE:1009 Type1.5_Front Inactive DFGin 4.4993 14.81 BLAminus -137.56, -175.69 71.07, 82.79 -97.11, 15.73 276.96, 54.31 -66.64, -22.13 out-out out 12.0688 Saltbr-out 11.2688 HRD-in -84.52, -50.1 80.24, 0.69 out-in-out SNCoio in-out ActLoopNT-in 2.7989 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -65.36, -16.47 APE9-dihe-na 124.74, -153.73 APE8-dihe-in -111.02, 130.63 APE8-rot-in 288.72 APE67-dihe-inflip 102.08, -11.75 -58.44, 133.55 APE12-dist-in 7.7205 APE11-dist-out 7.1414 APE10-dist-out 10.0972 APE9-dist-in 3.8992 None None None XRAY 2.43 0.184 0.251 A 448.0 403.0 0 31 31 0 [[571, 832]] 1.0 8uvl Homo sapiens OTHER_ERN1_HUMAN CAMK 3.3e-34 124.6 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 4YZDA O75460 563 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.1061 13.4537 BLBplus -141.52, 169.79 75.76, 4.13 -62.0, 156.83 53.76, 79.18 72.65, 35.33 out-out out 15.8851 Saltbr-out 13.4097 HRD-in -64.16, -47.27 74.91, -18.55 out-out-out SNCooo out-out ActLoopNT-out 10.5839 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -69.65, 158.55 APE9-dihe-na 98.62, 175.79 APE8-dihe-in -108.17, 135.68 APE8-rot-in 302.59 APE67-dihe-inflip 100.94, -24.59 -56.48, 129.95 APE12-dist-none 999.0 APE11-dist-in 13.4057 APE10-dist-out 8.1612 APE9-dist-in 3.4231 None None None XRAY 3.102 0.234 0.273 A 405.0 383.0 18 31 19 12 [[571, 832]] 1.0 4yzd Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 4YZDB O75460 563 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.2039 13.1793 BLBplus -141.12, 169.65 69.57, 15.58 -67.08, 155.42 48.06, 78.07 72.22, 36.23 out-out out 15.8795 Saltbr-out 13.1182 HRD-in -63.57, -45.81 74.7, -19.84 out-out-none SNCoon out-none ActLoopNT-out 10.5805 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -69.77, 158.99 APE9-dihe-na 99.89, 174.78 APE8-dihe-in -110.07, 134.42 APE8-rot-in 300.85 APE67-dihe-inflip 103.95, -24.75 -57.78, 133.16 APE12-dist-none 999.0 APE11-dist-in 12.6724 APE10-dist-in 7.5681 APE9-dist-in 3.5283 None None None XRAY 3.102 0.234 0.273 B 405.0 385.0 15 31 19 12 [[571, 832]] 1.0 4yzd Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 4YZDC O75460 563 964 977.0 ADP:1001 ATPlike Inactive DFGin 7.2921 13.5559 BLBplus -142.06, 170.34 76.33, 5.28 -64.41, 157.35 50.79, 79.33 73.41, 36.41 out-out out 16.1942 Saltbr-out 13.2528 HRD-in -63.95, -47.78 74.02, -20.41 out-out-none SNCoon out-none ActLoopNT-out 10.5812 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -70.78, 158.57 APE9-dihe-na 97.6, 174.43 APE8-dihe-in -111.17, 134.53 APE8-rot-in 303.43 APE67-dihe-inflip 103.93, -24.42 -56.8, 132.74 APE12-dist-none 999.0 APE11-dist-in 12.4096 APE10-dist-in 7.7835 APE9-dist-in 3.412 None None None XRAY 3.102 0.234 0.273 C 405.0 379.0 21 31 19 12 [[571, 832]] 1.0 4yzd Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 3P23A O75460 563 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.3396 13.7092 BLBplus -135.51, 176.11 64.76, 22.4 -82.8, 150.63 49.7, 79.84 86.4, 10.86 out-out out 16.0885 Saltbr-out 13.0695 HRD-in -67.24, -58.17 81.51, -4.45 out-out-out SNCooo out-out ActLoopNT-out 10.4016 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -84.29, 161.18 APE9-dihe-na 82.17, -162.33 APE8-dihe-in -132.44, 136.42 APE8-rot-in 302.1 APE67-dihe-inflip 108.83, 5.18 -54.01, 119.49 APE12-dist-none 999.0 APE11-dist-in 12.5576 APE10-dist-out 9.1227 APE9-dist-in 3.1961 None None None XRAY 2.7 0.238 0.294 A 432.0 386.0 15 31 19 12 [[571, 832]] 1.0 3p23 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 3P23B O75460 564 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.4832 13.6464 BLBplus -139.9, 176.5 76.83, 14.87 -83.89, 150.35 55.49, 87.42 97.57, -33.78 out-out out 15.9363 Saltbr-out 12.6575 HRD-in -62.38, -39.7 42.05, 35.85 out-out-out SNCooo out-out ActLoopNT-out 9.7011 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 143.86 APE9-dihe-na -111.46, -135.27 APE8-dihe-in -106.96, 135.19 APE8-rot-in 295.43 APE67-dihe-inflip 111.53, -14.08 -51.84, 125.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.2132 APE9-dist-in 3.4766 None None None XRAY 2.7 0.238 0.294 B 432.0 386.0 15 31 19 12 [[571, 832]] 1.0 3p23 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 3P23C O75460 561 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.5436 13.1728 BLBplus -149.53, -176.42 65.18, 18.98 -70.01, 144.07 39.63, 91.88 97.04, -114.33 out-out out 15.805 Saltbr-out 13.146 HRD-in -52.59, -55.72 76.18, 1.65 out-out-out SNCooo out-out ActLoopNT-out 11.1417 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioi APE10-dihe-na -53.61, -99.6 APE9-dihe-na -77.2, 171.08 APE8-dihe-in -47.05, 145.36 APE8-rot-in 345.28 APE67-dihe-out 116.59, -10.88 85.51, 60.96 APE12-dist-in 12.8381 APE11-dist-in 13.2434 APE10-dist-out 9.3534 APE9-dist-in 3.5072 None None None XRAY 2.7 0.238 0.294 C 432.0 390.0 14 31 20 11 [[571, 832]] 1.0 3p23 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 3P23D O75460 561 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.4094 13.2631 BLBplus -138.88, 177.03 72.28, 10.83 -71.52, 154.68 50.97, 93.75 83.32, -17.5 out-out out 16.034 Saltbr-out 13.0181 HRD-in -58.06, -54.76 77.4, -2.34 out-out-out SNCooo out-out ActLoopNT-out 10.0574 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnoi APE10-dihe-na 999.0, 162.88 APE9-dihe-na -149.96, -140.99 APE8-dihe-in -73.3, 139.85 APE8-rot-in 325.01 APE67-dihe-out 115.82, -9.19 91.28, 60.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.1125 APE9-dist-in 4.0378 None None None XRAY 2.7 0.238 0.294 D 432.0 387.0 16 31 17 14 [[571, 832]] 1.0 3p23 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 9N88A O75460 563 964 977.0 No_ligand No_ligand Inactive DFGin 4.4954 14.3964 BLBplus -125.12, 173.56 61.62, 32.01 -93.6, 167.16 52.37, 88.56 65.58, 27.08 in-in in 8.4049 Saltbr-in 2.935 HRD-in -63.01, -46.54 69.36, -1.22 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 159.47 APE9-dihe-na 82.39, -50.55 APE8-dihe-in -47.73, 127.95 APE8-rot-in 291.31 APE67-dihe-inflip 89.37, 13.1 -79.77, 123.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.4321 APE9-dist-out 7.9773 None None None EM 2.6 999.0 999.0 A 402.0 379.0 23 31 15 16 [[571, 832]] 1.0 9n88 Homo sapiens OTHER_ERN1_HUMAN CAMK 2.7e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 9N88E O75460 563 964 977.0 No_ligand No_ligand Inactive DFGin 4.4956 14.3957 BLBplus -125.13, 173.55 61.65, 32.03 -93.6, 167.11 52.36, 88.6 65.62, 27.08 in-in in 8.4049 Saltbr-in 2.9357 HRD-in -63.0, -46.58 69.41, -1.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 159.45 APE9-dihe-na 82.42, -50.53 APE8-dihe-in -47.73, 127.97 APE8-rot-in 291.31 APE67-dihe-inflip 89.32, 13.1 -79.8, 123.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.4328 APE9-dist-out 7.9774 None None None EM 2.6 999.0 999.0 E 402.0 379.0 23 31 15 16 [[571, 832]] 1.0 9n88 Homo sapiens OTHER_ERN1_HUMAN CAMK 2.7e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6W39A O75460 563 963 977.0 SJG:1001 Type1 Inactive DFGin 4.5887 14.5691 BLBplus -139.66, 174.98 64.22, 28.56 -90.96, 160.06 48.25, 86.99 74.2, -3.07 in-in in 8.8536 Saltbr-in 2.8681 HRD-in -66.64, -55.32 82.3, -19.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 171.9 APE8-rot-out 195.33 APE67-dihe-out 108.3, -8.16 -110.65, -131.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.736 0.197 0.235 A 431.0 374.0 24 31 12 19 [[571, 832]] 1.0 6w39 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6W39B O75460 563 963 977.0 SJG:1001 Type1 Inactive DFGin 4.6099 14.5377 BLBplus -144.1, 177.6 64.91, 27.62 -88.82, 154.64 46.85, 89.19 64.91, 16.36 in-in in 8.5816 Saltbr-in 3.5167 HRD-in -72.2, -52.15 80.89, -14.52 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -179.25 APE8-rot-out 67.26 APE67-dihe-out 104.99, -2.33 -121.34, -117.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.736 0.197 0.235 B 431.0 374.0 25 31 12 19 [[571, 832]] 1.0 6w39 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6W3AA O75460 562 964 977.0 SJM:1001 Type1 Inactive DFGin 4.6873 14.7501 BLBplus -159.03, 176.32 57.32, 40.69 -104.35, 145.33 50.26, 89.45 73.99, 38.41 in-in in 8.7186 Saltbr-in 2.9408 HRD-in -70.5, -44.05 68.58, -4.98 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 107.79 APE8-dihe-out -141.14, -179.39 APE8-rot-out 65.3 APE67-dihe-out 122.02, -15.91 -119.08, -128.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.5774 None None None XRAY 2.606 0.249 0.29 A 434.0 363.0 32 31 13 18 [[571, 832]] 1.0 6w3a Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6W3AB O75460 562 964 977.0 SJM:1001 Type1 Inactive DFGin 4.4445 14.5841 BLBplus -150.2, 175.33 54.85, 42.0 -103.74, 137.1 52.82, 87.58 88.2, 19.62 in-out in 8.5425 Saltbr-out 3.6453 HRD-in -69.7, -38.0 68.52, -8.14 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 121.7 APE8-dihe-out -126.01, -171.29 APE8-rot-out 66.29 APE67-dihe-out 116.07, -16.83 -111.97, -139.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.6537 None None None XRAY 2.606 0.249 0.29 B 434.0 371.0 25 31 14 17 [[571, 832]] 1.0 6w3a Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 4Z7GA O75460 562 963 977.0 No_ligand No_ligand Inactive DFGin 4.9957 14.5333 None -140.81, 175.34 43.48, 101.03 -87.72, 999.0 308.92, 94.22 999.0, 999.0 in-in in 8.9466 Saltbr-in 2.8404 HRD-in -60.57, -47.56 72.24, -10.39 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, -18.99 APE9-dihe-na -167.3, -173.38 APE8-dihe-in -130.49, 124.62 APE8-rot-out 52.96 APE67-dihe-inflip 106.42, -11.92 -35.23, 118.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.8338 None None None XRAY 2.6 0.204 0.226 A 416.0 366.0 26 31 12 19 [[571, 832]] 1.0 4z7g Homo sapiens OTHER_ERN1_HUMAN CAMK 3e-35 128.0 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 4Z7GB O75460 562 962 977.0 No_ligand No_ligand Inactive DFGin 4.9099 14.386 None -141.89, 174.99 45.35, 92.04 -84.88, 999.0 313.4, 110.77 999.0, 999.0 in-in in 8.916 Saltbr-in 2.8322 HRD-in -60.96, -47.53 72.73, -11.47 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na -63.92, -20.1 APE9-dihe-na -168.1, 175.6 APE8-dihe-in -122.17, 125.73 APE8-rot-out 53.21 APE67-dihe-inflip 110.25, -18.1 -36.38, 118.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.8352 None None None XRAY 2.6 0.204 0.226 B 416.0 377.0 24 31 13 18 [[571, 832]] 1.0 4z7g Homo sapiens OTHER_ERN1_HUMAN CAMK 3e-35 128.0 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 4Z7HA O75460 562 963 977.0 4L5:1001 Type1 Inactive DFGin 5.3928 14.9773 None -138.87, -45.43 -76.98, 88.77 -83.95, 3.75 273.49, 77.38 -61.03, -41.59 in-in in 8.8506 Saltbr-in 2.8087 HRD-in -73.17, -46.77 63.73, 3.56 in-in-out SNCiio in-out ActLoopNT-in 2.9283 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, -6.85 APE9-dihe-na 151.6, -155.97 APE8-dihe-in -123.5, 123.79 APE8-rot-out 45.5 APE67-dihe-inflip 106.26, -20.23 -56.36, 141.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.6127 APE9-dist-in 4.6464 None None None XRAY 2.9 0.202 0.225 A 416.0 385.0 10 31 26 5 [[571, 832]] 1.0 4z7h Homo sapiens OTHER_ERN1_HUMAN CAMK 3e-35 128.0 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 4YZ9A O75460 562 964 977.0 4K7:1001 Type3 Inactive DFGout 15.9304 7.2574 None -145.42, 154.32 -79.25, -25.27 -113.1, 147.21 74.93, 92.08 -101.05, 170.75 out-out out 11.465 Saltbr-out 6.557 HRD-in -65.78, -56.93 75.18, -20.46 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 65.49 APE8-dihe-out -91.72, -3.5 APE8-rot-out 69.34 APE67-dihe-inflip 101.89, 14.03 -97.24, 145.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.7819 None None None XRAY 2.463 0.238 0.283 A 405.0 381.0 22 31 14 17 [[571, 832]] 1.0 4yz9 Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 4YZ9B O75460 563 963 977.0 4K7:1001 Type3 Inactive DFGout 17.0401 7.2662 None -150.4, 164.44 -74.79, -40.79 -115.62, 154.13 77.21, 107.48 -102.62, 170.51 out-out out 12.3592 Saltbr-out 7.6157 HRD-in -70.74, -51.1 76.22, -19.19 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 103.24, -20.76 999.0, -159.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.463 0.238 0.283 B 405.0 375.0 24 31 12 19 [[571, 832]] 1.0 4yz9 Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 4YZ9C O75460 562 964 977.0 4K7:1001 Type3 Inactive DFGout 15.914 7.1097 None -135.14, 175.91 -93.49, -10.88 -129.03, 149.22 68.81, 88.89 -96.28, -179.45 out-out out 11.562 Saltbr-out 6.7491 HRD-in -69.18, -49.88 66.0, -15.77 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -33.06 APE8-rot-in 308.85 APE67-dihe-inflip 96.07, 16.76 -122.57, 162.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.463 0.238 0.283 C 405.0 378.0 25 31 13 18 [[571, 832]] 1.0 4yz9 Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6HX1A O75460 562 964 977.0 GXK:1001 Type1 Inactive None 999.0 9.0308 None -117.25, 153.54 -78.62, -34.04 -91.96, 133.47 286.33, 72.45 -93.93, 146.96 none-none none 999.0 Saltbr-none 999.0 HRD-in -64.4, -55.14 79.73, -2.12 none-out-out SNCnoo out-out ActLoopNT-out 22.4776 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -51.71, 130.91 APE9-dihe-na 103.58, -28.73 APE8-dihe-out -114.51, 37.72 APE8-rot-out 76.32 APE67-dihe-in -78.77, 3.79 -81.24, -41.88 APE12-dist-in 12.3412 APE11-dist-in 9.3784 APE10-dist-out 11.3233 APE9-dist-out 15.6953 None None None XRAY 2.14 0.219 0.268 A 403.0 387.0 16 31 29 2 [[571, 832]] 1.0 6hx1 Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6HV0A O75460 562 963 977.0 GUK:1001 Type1 Inactive None 999.0 9.1821 None -133.1, 153.75 -66.3, -48.4 -89.37, 135.79 292.63, 70.49 -93.67, 142.5 none-none none 999.0 Saltbr-none 999.0 HRD-in -70.37, -40.56 70.66, -13.49 none-out-out SNCnoo out-out ActLoopNT-out 22.5117 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -88.59, 128.96 APE9-dihe-na -116.2, 97.18 APE8-dihe-out -118.13, -15.29 APE8-rot-in 276.8 APE67-dihe-inflip 101.83, -26.03 -49.76, 144.64 APE12-dist-in 12.836 APE11-dist-in 10.0861 APE10-dist-out 11.6617 APE9-dist-out 15.7445 None None None XRAY 2.73 0.217 0.269 A 416.0 377.0 23 31 31 0 [[571, 832]] 1.0 6hv0 Homo sapiens OTHER_ERN1_HUMAN CAMK 3e-35 128.0 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 4YZCA O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.5402 13.5982 BLAminus -149.66, -173.45 57.49, 66.53 -77.65, -2.16 287.89, 65.87 -48.01, -38.7 in-none in 9.3632 Saltbr-none 999.0 HRD-in -69.99, -44.37 70.23, -12.54 none-in-in SNCnii in-in ActLoopNT-in 2.8966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -68.95, 160.8 APE9-dihe-na 106.7, 168.85 APE8-dihe-in -105.56, 142.33 APE8-rot-in 309.63 APE67-dihe-inflip 90.78, -21.58 -55.3, 131.97 APE12-dist-in 10.4006 APE11-dist-in 11.3276 APE10-dist-in 5.4058 APE9-dist-in 3.6014 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 A 405.0 385.0 17 31 30 1 [[571, 832]] 1.0 4yzc Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 4YZCB O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.3622 13.613 BLAminus -140.88, -173.22 59.3, 72.64 -84.99, 5.45 286.37, 62.28 -53.44, -38.69 in-none in 9.6084 Saltbr-none 999.0 HRD-in -70.83, -44.64 74.46, -16.49 none-in-in SNCnii in-in ActLoopNT-in 2.9715 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -78.48, 164.52 APE9-dihe-na 106.87, 177.31 APE8-dihe-in -111.04, 139.81 APE8-rot-in 310.36 APE67-dihe-inflip 90.66, -20.76 -52.98, 131.15 APE12-dist-in 10.8362 APE11-dist-in 11.2328 APE10-dist-in 5.3941 APE9-dist-in 3.6931 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 B 405.0 384.0 18 31 29 2 [[571, 832]] 1.0 4yzc Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_HUMAN 6W3KA O75460 562 963 977.0 SJS:1001 Type1 None DFGin 5.733 14.4855 BLAminus -136.61, -178.37 67.07, 78.89 -100.93, 17.07 281.07, 41.19 -67.11, -27.01 in-in in 8.2042 Saltbr-in 2.756 HRD-in -74.42, -52.27 75.94, 0.0 in-in-none SNCiin in-none ActLoopNT-in 2.8974 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 69.85 APE9-dihe-na 125.22, -177.52 APE8-dihe-in -111.61, 120.85 APE8-rot-in 306.38 APE67-dihe-inflip 105.25, -16.79 -50.22, 133.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.7294 APE9-dist-in 3.9769 None None None XRAY 2.08 0.192 0.217 A 434.0 398.0 4 31 27 4 [[571, 832]] 1.0 6w3k Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.8 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL4B Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.3927 13.4972 BLBplus -131.17, -171.5 49.73, 22.15 -77.96, 172.77 53.0, 89.01 68.36, -18.97 out-out out 16.1855 Saltbr-out 12.8674 HRD-in -71.43, -56.11 80.63, -15.27 out-out-out SNCooo out-out ActLoopNT-out 10.3004 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -71.5, 161.7 APE9-dihe-na 95.56, 170.85 APE8-dihe-in -126.15, 140.57 APE8-rot-in 313.23 APE67-dihe-inflip 115.41, -9.81 -59.18, 119.64 APE12-dist-none 999.0 APE11-dist-in 13.3728 APE10-dist-out 8.9632 APE9-dist-in 3.3017 N772Y None None XRAY 3.0 0.213 0.276 B 435.0 384.0 18 31 19 12 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL4C Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.5482 14.2484 BLBplus -126.51, -173.84 57.1, 11.03 -79.33, 148.55 56.35, 128.67 90.22, -11.73 out-out out 16.9717 Saltbr-out 13.4493 HRD-in -87.09, -33.21 64.61, -28.11 out-out-out SNCooo out-out ActLoopNT-out 10.6681 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioi APE10-dihe-na -75.07, 168.04 APE9-dihe-na 83.31, 160.45 APE8-dihe-in -117.06, 150.3 APE8-rot-out 84.63 APE67-dihe-inflip 114.33, -11.46 -59.41, 124.52 APE12-dist-none 999.0 APE11-dist-in 13.4836 APE10-dist-out 8.4493 APE9-dist-in 3.5542 N772Y None None XRAY 3.0 0.213 0.276 C 435.0 384.0 18 31 19 12 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL4D Q9EQY0 562 961 977.0 ADP:1001 ATPlike Inactive DFGin 7.5079 13.71 BLBplus -135.47, -173.14 51.5, 21.77 -87.04, 144.38 56.66, 114.14 91.93, -17.13 out-out out 15.9791 Saltbr-out 13.3396 HRD-in -83.86, -32.09 72.35, -48.88 out-out-out SNCooo out-out ActLoopNT-out 10.328 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -70.73, 154.49 APE9-dihe-na 96.39, -168.63 APE8-dihe-in -140.56, 130.56 APE8-rot-in 311.25 APE67-dihe-inflip 116.72, -15.16 -51.06, 117.77 APE12-dist-none 999.0 APE11-dist-in 13.9703 APE10-dist-out 9.1376 APE9-dist-in 3.9224 N772Y None None XRAY 3.0 0.213 0.276 D 435.0 377.0 18 31 19 12 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL5B Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.4546 13.9365 BLBplus -129.37, -173.23 56.7, 18.18 -83.15, 166.18 46.51, 88.1 78.73, -17.65 out-out out 17.3785 Saltbr-out 14.0508 HRD-in -57.7, -43.88 69.49, -15.96 out-out-out SNCooo out-out ActLoopNT-out 10.0479 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nioi APE10-dihe-na -68.77, 169.09 APE9-dihe-na 94.26, -167.14 APE8-dihe-in -147.72, 134.59 APE8-rot-in 292.91 APE67-dihe-out 142.49, -27.58 -41.24, 92.94 APE12-dist-none 999.0 APE11-dist-in 13.2922 APE10-dist-out 8.4459 APE9-dist-in 3.3559 N772Y None None XRAY 3.4 0.225 0.285 B 435.0 383.0 19 31 18 13 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL5C Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.7942 14.0613 BLBplus -140.3, -178.86 59.78, 31.79 -102.25, 171.48 50.28, 80.31 73.36, 0.55 out-out out 16.8522 Saltbr-out 12.6343 HRD-in -71.26, -29.05 67.43, -40.0 out-out-out SNCooo out-out ActLoopNT-out 10.5425 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -68.61, -176.62 APE9-dihe-na 79.33, -164.24 APE8-dihe-in -141.99, 145.59 APE8-rot-in 309.7 APE67-dihe-inflip 125.8, -7.43 -55.77, 102.3 APE12-dist-none 999.0 APE11-dist-in 13.6845 APE10-dist-out 8.5993 APE9-dist-in 3.6488 N772Y None None XRAY 3.4 0.225 0.285 C 435.0 386.0 16 31 20 11 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL5D Q9EQY0 561 963 977.0 ADP:1001 ATPlike Inactive DFGin 6.8833 13.7093 BLBplus -149.88, 177.73 60.77, 34.53 -99.83, 170.66 50.74, 82.52 85.0, -30.32 out-out out 16.8731 Saltbr-out 16.3097 HRD-in -73.87, -31.52 63.42, -30.41 out-out-out SNCooo out-out ActLoopNT-out 10.8618 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioi APE10-dihe-na -64.48, 167.99 APE9-dihe-na 99.63, 173.49 APE8-dihe-in -124.29, 140.67 APE8-rot-out 174.47 APE67-dihe-inflip 122.64, -17.06 -61.26, 114.95 APE12-dist-none 999.0 APE11-dist-in 13.2318 APE10-dist-out 8.1121 APE9-dist-in 3.9187 N772Y None None XRAY 3.4 0.225 0.285 D 435.0 385.0 18 31 19 12 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL3A Q9EQY0 560 964 977.0 31J:1001,ADP:1002 Allosteric,ATPlike Inactive DFGin 7.327 13.7163 BLBplus -137.83, -169.53 45.26, 38.38 -99.01, 160.39 56.61, 78.79 64.67, 4.33 out-out out 16.5791 Saltbr-out 12.4483 HRD-in -67.88, -49.57 75.5, 1.96 out-out-out SNCooo out-out ActLoopNT-out 9.693 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -56.59, -179.83 APE9-dihe-na 70.82, 169.1 APE8-dihe-in -122.85, 127.5 APE8-rot-in 297.91 APE67-dihe-inflip 117.64, -32.26 -39.31, 118.58 APE12-dist-none 999.0 APE11-dist-out 14.0611 APE10-dist-out 9.3121 APE9-dist-in 3.5586 N772Y None None XRAY 2.9 0.202 0.234 A 435.0 388.0 17 31 19 12 [[571, 832]] 1.0 4pl3 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL3B Q9EQY0 562 963 977.0 31J:1001,ADP:1002 Allosteric,ATPlike Inactive DFGin 7.3343 13.8933 BLBplus -148.72, -173.45 55.21, 14.76 -81.6, 169.54 60.69, 84.7 79.59, -5.1 out-out out 16.5804 Saltbr-out 13.2885 HRD-in -77.64, -56.6 82.71, -30.85 out-out-out SNCooo out-out ActLoopNT-out 10.6216 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -64.56, 166.09 APE9-dihe-na 91.33, -176.0 APE8-dihe-in -135.33, 135.79 APE8-rot-in 299.82 APE67-dihe-inflip 121.38, -25.98 -48.92, 119.9 APE12-dist-none 999.0 APE11-dist-out 14.1225 APE10-dist-out 9.3359 APE9-dist-in 3.6949 N772Y None None XRAY 2.9 0.202 0.234 B 435.0 383.0 19 31 18 13 [[571, 832]] 1.0 4pl3 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL4A Q9EQY0 562 963 977.0 31K:1001,ADP:1002 Allosteric,ATPlike Inactive DFGin 6.7883 14.2186 BLBplus -105.14, -174.11 44.38, 29.11 -94.38, 143.46 69.8, 104.54 103.76, -33.08 out-out out 16.6052 Saltbr-out 13.2732 HRD-in -77.26, -47.59 71.94, -10.31 out-out-out SNCooo out-out ActLoopNT-out 10.5629 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -61.91, 153.92 APE9-dihe-na 102.53, -174.53 APE8-dihe-in -133.87, 129.13 APE8-rot-in 297.04 APE67-dihe-inflip 119.89, -24.27 -52.28, 118.86 APE12-dist-none 999.0 APE11-dist-out 14.3788 APE10-dist-out 9.4324 APE9-dist-in 3.2964 N772Y None None XRAY 3.0 0.213 0.276 A 435.0 385.0 17 31 20 11 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL5A Q9EQY0 562 964 977.0 31L:1001,ADP:1002,PEU:1004 Allosteric,ATPlike,Allosteric Inactive DFGin 6.5845 13.7552 BLBplus -127.28, -167.94 47.08, 28.46 -89.65, 160.5 62.46, 164.78 70.79, 0.93 out-out out 16.2962 Saltbr-out 12.729 HRD-in -75.22, -42.28 71.55, -19.88 out-out-out SNCooo out-out ActLoopNT-out 10.4865 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -69.09, -179.67 APE9-dihe-na 72.79, -173.9 APE8-dihe-in -128.85, 142.84 APE8-rot-in 291.98 APE67-dihe-inflip 114.76, -25.15 -48.2, 123.54 APE12-dist-none 999.0 APE11-dist-in 13.7986 APE10-dist-out 8.5968 APE9-dist-in 3.4978 N772Y None None XRAY 3.4 0.225 0.285 A 435.0 386.0 17 31 19 12 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1

OTHER_ERN1 (Serine/threonine-protein kinase/endoribonuclease IRE1)

Total number of chains: 10
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 10 100.0% 4PL5C

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ERN1 ERN1_MOUSE 4PL4B Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.3927 13.4972 BLBplus -131.17, -171.5 49.73, 22.15 -77.96, 172.77 53.0, 89.01 68.36, -18.97 out-out out 16.1855 Saltbr-out 12.8674 HRD-in -71.43, -56.11 80.63, -15.27 out-out-out SNCooo out-out ActLoopNT-out 10.3004 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -71.5, 161.7 APE9-dihe-na 95.56, 170.85 APE8-dihe-in -126.15, 140.57 APE8-rot-in 313.23 APE67-dihe-inflip 115.41, -9.81 -59.18, 119.64 APE12-dist-none 999.0 APE11-dist-in 13.3728 APE10-dist-out 8.9632 APE9-dist-in 3.3017 N772Y None None XRAY 3.0 0.213 0.276 B 435.0 384.0 18 31 19 12 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL4C Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.5482 14.2484 BLBplus -126.51, -173.84 57.1, 11.03 -79.33, 148.55 56.35, 128.67 90.22, -11.73 out-out out 16.9717 Saltbr-out 13.4493 HRD-in -87.09, -33.21 64.61, -28.11 out-out-out SNCooo out-out ActLoopNT-out 10.6681 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioi APE10-dihe-na -75.07, 168.04 APE9-dihe-na 83.31, 160.45 APE8-dihe-in -117.06, 150.3 APE8-rot-out 84.63 APE67-dihe-inflip 114.33, -11.46 -59.41, 124.52 APE12-dist-none 999.0 APE11-dist-in 13.4836 APE10-dist-out 8.4493 APE9-dist-in 3.5542 N772Y None None XRAY 3.0 0.213 0.276 C 435.0 384.0 18 31 19 12 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL4D Q9EQY0 562 961 977.0 ADP:1001 ATPlike Inactive DFGin 7.5079 13.71 BLBplus -135.47, -173.14 51.5, 21.77 -87.04, 144.38 56.66, 114.14 91.93, -17.13 out-out out 15.9791 Saltbr-out 13.3396 HRD-in -83.86, -32.09 72.35, -48.88 out-out-out SNCooo out-out ActLoopNT-out 10.328 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -70.73, 154.49 APE9-dihe-na 96.39, -168.63 APE8-dihe-in -140.56, 130.56 APE8-rot-in 311.25 APE67-dihe-inflip 116.72, -15.16 -51.06, 117.77 APE12-dist-none 999.0 APE11-dist-in 13.9703 APE10-dist-out 9.1376 APE9-dist-in 3.9224 N772Y None None XRAY 3.0 0.213 0.276 D 435.0 377.0 18 31 19 12 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL5B Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.4546 13.9365 BLBplus -129.37, -173.23 56.7, 18.18 -83.15, 166.18 46.51, 88.1 78.73, -17.65 out-out out 17.3785 Saltbr-out 14.0508 HRD-in -57.7, -43.88 69.49, -15.96 out-out-out SNCooo out-out ActLoopNT-out 10.0479 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nioi APE10-dihe-na -68.77, 169.09 APE9-dihe-na 94.26, -167.14 APE8-dihe-in -147.72, 134.59 APE8-rot-in 292.91 APE67-dihe-out 142.49, -27.58 -41.24, 92.94 APE12-dist-none 999.0 APE11-dist-in 13.2922 APE10-dist-out 8.4459 APE9-dist-in 3.3559 N772Y None None XRAY 3.4 0.225 0.285 B 435.0 383.0 19 31 18 13 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL5C Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.7942 14.0613 BLBplus -140.3, -178.86 59.78, 31.79 -102.25, 171.48 50.28, 80.31 73.36, 0.55 out-out out 16.8522 Saltbr-out 12.6343 HRD-in -71.26, -29.05 67.43, -40.0 out-out-out SNCooo out-out ActLoopNT-out 10.5425 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -68.61, -176.62 APE9-dihe-na 79.33, -164.24 APE8-dihe-in -141.99, 145.59 APE8-rot-in 309.7 APE67-dihe-inflip 125.8, -7.43 -55.77, 102.3 APE12-dist-none 999.0 APE11-dist-in 13.6845 APE10-dist-out 8.5993 APE9-dist-in 3.6488 N772Y None None XRAY 3.4 0.225 0.285 C 435.0 386.0 16 31 20 11 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL5D Q9EQY0 561 963 977.0 ADP:1001 ATPlike Inactive DFGin 6.8833 13.7093 BLBplus -149.88, 177.73 60.77, 34.53 -99.83, 170.66 50.74, 82.52 85.0, -30.32 out-out out 16.8731 Saltbr-out 16.3097 HRD-in -73.87, -31.52 63.42, -30.41 out-out-out SNCooo out-out ActLoopNT-out 10.8618 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioi APE10-dihe-na -64.48, 167.99 APE9-dihe-na 99.63, 173.49 APE8-dihe-in -124.29, 140.67 APE8-rot-out 174.47 APE67-dihe-inflip 122.64, -17.06 -61.26, 114.95 APE12-dist-none 999.0 APE11-dist-in 13.2318 APE10-dist-out 8.1121 APE9-dist-in 3.9187 N772Y None None XRAY 3.4 0.225 0.285 D 435.0 385.0 18 31 19 12 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL3A Q9EQY0 560 964 977.0 31J:1001,ADP:1002 Allosteric,ATPlike Inactive DFGin 7.327 13.7163 BLBplus -137.83, -169.53 45.26, 38.38 -99.01, 160.39 56.61, 78.79 64.67, 4.33 out-out out 16.5791 Saltbr-out 12.4483 HRD-in -67.88, -49.57 75.5, 1.96 out-out-out SNCooo out-out ActLoopNT-out 9.693 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -56.59, -179.83 APE9-dihe-na 70.82, 169.1 APE8-dihe-in -122.85, 127.5 APE8-rot-in 297.91 APE67-dihe-inflip 117.64, -32.26 -39.31, 118.58 APE12-dist-none 999.0 APE11-dist-out 14.0611 APE10-dist-out 9.3121 APE9-dist-in 3.5586 N772Y None None XRAY 2.9 0.202 0.234 A 435.0 388.0 17 31 19 12 [[571, 832]] 1.0 4pl3 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL3B Q9EQY0 562 963 977.0 31J:1001,ADP:1002 Allosteric,ATPlike Inactive DFGin 7.3343 13.8933 BLBplus -148.72, -173.45 55.21, 14.76 -81.6, 169.54 60.69, 84.7 79.59, -5.1 out-out out 16.5804 Saltbr-out 13.2885 HRD-in -77.64, -56.6 82.71, -30.85 out-out-out SNCooo out-out ActLoopNT-out 10.6216 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -64.56, 166.09 APE9-dihe-na 91.33, -176.0 APE8-dihe-in -135.33, 135.79 APE8-rot-in 299.82 APE67-dihe-inflip 121.38, -25.98 -48.92, 119.9 APE12-dist-none 999.0 APE11-dist-out 14.1225 APE10-dist-out 9.3359 APE9-dist-in 3.6949 N772Y None None XRAY 2.9 0.202 0.234 B 435.0 383.0 19 31 18 13 [[571, 832]] 1.0 4pl3 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL4A Q9EQY0 562 963 977.0 31K:1001,ADP:1002 Allosteric,ATPlike Inactive DFGin 6.7883 14.2186 BLBplus -105.14, -174.11 44.38, 29.11 -94.38, 143.46 69.8, 104.54 103.76, -33.08 out-out out 16.6052 Saltbr-out 13.2732 HRD-in -77.26, -47.59 71.94, -10.31 out-out-out SNCooo out-out ActLoopNT-out 10.5629 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -61.91, 153.92 APE9-dihe-na 102.53, -174.53 APE8-dihe-in -133.87, 129.13 APE8-rot-in 297.04 APE67-dihe-inflip 119.89, -24.27 -52.28, 118.86 APE12-dist-none 999.0 APE11-dist-out 14.3788 APE10-dist-out 9.4324 APE9-dist-in 3.2964 N772Y None None XRAY 3.0 0.213 0.276 A 435.0 385.0 17 31 20 11 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
ERN1 ERN1_MOUSE 4PL5A Q9EQY0 562 964 977.0 31L:1001,ADP:1002,PEU:1004 Allosteric,ATPlike,Allosteric Inactive DFGin 6.5845 13.7552 BLBplus -127.28, -167.94 47.08, 28.46 -89.65, 160.5 62.46, 164.78 70.79, 0.93 out-out out 16.2962 Saltbr-out 12.729 HRD-in -75.22, -42.28 71.55, -19.88 out-out-out SNCooo out-out ActLoopNT-out 10.4865 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -69.09, -179.67 APE9-dihe-na 72.79, -173.9 APE8-dihe-in -128.85, 142.84 APE8-rot-in 291.98 APE67-dihe-inflip 114.76, -25.15 -48.2, 123.54 APE12-dist-none 999.0 APE11-dist-in 13.7986 APE10-dist-out 8.5968 APE9-dist-in 3.4978 N772Y None None XRAY 3.4 0.225 0.285 A 435.0 386.0 17 31 19 12 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1