Protein kinases in complex with DB8 (Bosutinib)

Total number of genes: 11
Total number of chains: 25
Spatial Dihedral Chains Representative
DFGin BLAminus 17 5VCYA
DFGin BLBminus 1 5I9XA
DFGin BLBplus 1 6OP9A
DFGin None 2 5AJQA
DFGinter BABtrans 1 4MXXB
DFGinter None 1 3SOAA
DFGout None 2 3UE4A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
CAMK CAMK2A KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha 3SOAA 3.55 Inactive DFGinter None in-none in-in DB8 Type1
CAMK SIK3 SIK3_HUMAN Serine/threonine-protein kinase SIK3 8R4QA 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1
CAMK SIK3 SIK3_HUMAN Serine/threonine-protein kinase SIK3 8R4QC 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1
CAMK SIK3 SIK3_HUMAN Serine/threonine-protein kinase SIK3 8R4QE 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1
CAMK SIK3 SIK3_HUMAN Serine/threonine-protein kinase SIK3 8R4QG 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1
CAMK SIK3 SIK3_HUMAN Serine/threonine-protein kinase SIK3 8R4QI 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1
CAMK SIK3 SIK3_HUMAN Serine/threonine-protein kinase SIK3 8R4QK 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1
OTHER PKMYT1 PMYT1_HUMAN Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 5VCYA 1.56 Active DFGin BLAminus in-in in-in DB8 Type1
OTHER ULK3 ULK3_HUMAN Serine/threonine-protein kinase ULK3 6FDYU 1.7 Inactive DFGin BLAminus out-out in-in DB8 DB8 Type1 Allosteric
OTHER WEE1 WEE1_HUMAN Wee1-like protein kinase 5VC3A 1.97 Inactive DFGin BLAminus out-out in-in DB8 Type1
STE STK10 STK10_HUMAN Serine/threonine-protein kinase 10 5AJQA 2.2 Inactive DFGin None out-out out-out DB8 Type1
STE STK10 STK10_HUMAN Serine/threonine-protein kinase 10 5AJQB 2.2 Inactive DFGin None out-none out-none DB8 Type1
STE STK24 STK24_HUMAN Serine/threonine-protein kinase 24 4QMNA 2.091 Active DFGin BLAminus in-in in-in DB8 Type1
TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 3UE4A 2.424 Inactive DFGout None in-out out-in DB8 Type1
TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 3UE4B 2.424 Inactive DFGout None in-out out-in DB8 Type1
TYR EPHA2 EPHA2_HUMAN Ephrin type-A receptor 2 5I9XA 1.427 Inactive DFGin BLBminus in-in out-in DB8 Type1
TYR ERBB3 ERBB3_HUMAN Receptor tyrosine-protein kinase erbB-3 6OP9A 2.501 Inactive DFGin BLBplus out-none out-in DB8 Type1
TYR SRC SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src 4MXYA 2.582 Inactive DFGin BLAminus in-out in-in DB8 Type1
TYR SRC SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src 4MXYB 2.582 Inactive DFGin BLAminus in-out in-in DB8 Type1
TYR SRC SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src 4MXZA 2.582 Inactive DFGin BLAminus in-out in-in DB8 Type1
TYR SRC SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src 4MXZB 2.582 Inactive DFGin BLAminus in-out in-in DB8 Type1
TYR SRC SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src 4MXXA 2.6 Inactive DFGin BLAminus in-out in-in DB8 Type1
TYR SRC SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src 4MXOA 2.105 Active DFGin BLAminus in-in in-in DB8 Type1
TYR SRC SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src 4MXOB 2.105 Active DFGin BLAminus in-in in-in DB8 Type1
TYR SRC SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src 4MXXB 2.6 Inactive DFGinter BABtrans out-out none-in DB8 Type1

Protein kinases in complex with DB8

Total number of genes: 11
Total number of chains: 25
Spatial Dihedral Chains Representative
DFGin BLAminus 17 5VCYA
DFGin BLBminus 1 5I9XA
DFGin BLBplus 1 6OP9A
DFGin None 2 5AJQA
DFGinter BABtrans 1 4MXXB
DFGinter None 1 3SOAA
DFGout None 2 3UE4A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens CAMK CAMK2A KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha 3SOAA 3.55 Inactive DFGinter None in-none in-in DB8 Type1
Homo sapiens CAMK SIK3 SIK3_HUMAN Serine/threonine-protein kinase SIK3 8R4QA 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1
Homo sapiens CAMK SIK3 SIK3_HUMAN Serine/threonine-protein kinase SIK3 8R4QC 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1
Homo sapiens CAMK SIK3 SIK3_HUMAN Serine/threonine-protein kinase SIK3 8R4QE 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1
Homo sapiens CAMK SIK3 SIK3_HUMAN Serine/threonine-protein kinase SIK3 8R4QG 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1
Homo sapiens CAMK SIK3 SIK3_HUMAN Serine/threonine-protein kinase SIK3 8R4QI 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1
Homo sapiens CAMK SIK3 SIK3_HUMAN Serine/threonine-protein kinase SIK3 8R4QK 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1
Homo sapiens OTHER PKMYT1 PMYT1_HUMAN Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 5VCYA 1.56 Active DFGin BLAminus in-in in-in DB8 Type1
Homo sapiens OTHER ULK3 ULK3_HUMAN Serine/threonine-protein kinase ULK3 6FDYU 1.7 Inactive DFGin BLAminus out-out in-in DB8 DB8 Type1 Allosteric
Homo sapiens OTHER WEE1 WEE1_HUMAN Wee1-like protein kinase 5VC3A 1.97 Inactive DFGin BLAminus out-out in-in DB8 Type1
Homo sapiens STE STK10 STK10_HUMAN Serine/threonine-protein kinase 10 5AJQA 2.2 Inactive DFGin None out-out out-out DB8 Type1
Homo sapiens STE STK10 STK10_HUMAN Serine/threonine-protein kinase 10 5AJQB 2.2 Inactive DFGin None out-none out-none DB8 Type1
Homo sapiens STE STK24 STK24_HUMAN Serine/threonine-protein kinase 24 4QMNA 2.091 Active DFGin BLAminus in-in in-in DB8 Type1
Homo sapiens TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 3UE4A 2.424 Inactive DFGout None in-out out-in DB8 Type1
Homo sapiens TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 3UE4B 2.424 Inactive DFGout None in-out out-in DB8 Type1
Homo sapiens TYR EPHA2 EPHA2_HUMAN Ephrin type-A receptor 2 5I9XA 1.427 Inactive DFGin BLBminus in-in out-in DB8 Type1
Homo sapiens TYR ERBB3 ERBB3_HUMAN Receptor tyrosine-protein kinase erbB-3 6OP9A 2.501 Inactive DFGin BLBplus out-none out-in DB8 Type1
Homo sapiens TYR SRC SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src 4MXYA 2.582 Inactive DFGin BLAminus in-out in-in DB8 Type1
Homo sapiens TYR SRC SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src 4MXYB 2.582 Inactive DFGin BLAminus in-out in-in DB8 Type1
Homo sapiens TYR SRC SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src 4MXZA 2.582 Inactive DFGin BLAminus in-out in-in DB8 Type1
Homo sapiens TYR SRC SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src 4MXZB 2.582 Inactive DFGin BLAminus in-out in-in DB8 Type1
Homo sapiens TYR SRC SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src 4MXXA 2.6 Inactive DFGin BLAminus in-out in-in DB8 Type1
Homo sapiens TYR SRC SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src 4MXOA 2.105 Active DFGin BLAminus in-in in-in DB8 Type1
Homo sapiens TYR SRC SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src 4MXOB 2.105 Active DFGin BLAminus in-in in-in DB8 Type1
Homo sapiens TYR SRC SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src 4MXXB 2.6 Inactive DFGinter BABtrans out-out none-in DB8 Type1

Protein kinases in complex with DB8

Total number of genes: 0
Total number of chains: 0
Spatial Dihedral Chains Representative
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type