SIK3 (Serine/threonine-protein kinase SIK3)

Group: CAMK
Uniprot: SIK3_HUMAN
Domain boundary: 66 - 317


Total number of chains: 22
Spatial Dihedral Chains Representative
DFGin BLAminus 20 AF-Q9Y2K2-K1A
DFGin ABAminus 2 8R4VB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
8R4VB 1.9 Inactive DFGin ABAminus out-out in-in XWA Type1 61 - 384 C121S,C181S,C333S X221 0
8R4VC 1.9 Inactive DFGin ABAminus out-out in-in XWA Type1 61 - 385 C121S,C181S,C333S X221 0
AF-Q9Y2K2-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 58 - 325 None None 0
8R4OA 2.725 Active DFGin BLAminus in-in in-in XVI Type1 62 - 384 C121S,C181S,C333S X221 0
8R4OC 2.725 Active DFGin BLAminus in-in in-in XVI Type1 62 - 384 C121S,C181S,C333S X221 0
8R4OE 2.725 Active DFGin BLAminus in-in in-in XVI Type1 62 - 384 C121S,C181S,C333S X221 0
8R4OG 2.725 Active DFGin BLAminus in-in in-in XVI Type1 62 - 384 C121S,C181S,C333S X221 0
8R4OI 2.725 Active DFGin BLAminus in-in in-in XVI Type1 62 - 384 C121S,C181S,C333S X221 0
8R4OK 2.725 Active DFGin BLAminus in-in in-in XVI Type1 62 - 384 C121S,C181S,C333S X221 0
8R4QA 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1 62 - 384 C121S,C181S,C333S X221 0
8R4QC 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1 62 - 384 C121S,C181S,C333S X221 0
8R4QE 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1 62 - 384 C121S,C181S,C333S X221 0
8R4QG 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1 62 - 384 C121S,C181S,C333S X221 0
8R4QI 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1 62 - 384 C121S,C181S,C333S X221 0
8R4QK 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1 62 - 384 C121S,C181S,C333S X221 0
8R4VA 1.9 Inactive DFGin BLAminus out-out in-in XWA Type1 62 - 385 C121S,C181S,C333S X221 0
8OKUA 3.1 Active DFGin BLAminus in-in in-in VRU Type1 60 - 392 T221D None 0
8OKUB 3.1 Active DFGin BLAminus in-in in-in VRU Type1 60 - 390 T221D None 0
8R4UA 2.416 Inactive DFGin BLAminus in-out in-in XW3 Type1.5_Front 61 - 384 C121S,C181S,C333S X221 0
8R4UC 2.416 Inactive DFGin BLAminus in-out in-in XW3 Type1.5_Front 62 - 384 C121S,C181S,C333S X221 0
8R4UE 2.416 Inactive DFGin BLAminus in-out in-in XW3 Type1.5_Front 61 - 384 C121S,C181S,C333S X221 0
8R4UG 2.416 Inactive DFGin BLAminus in-out in-in XW3 Type1.5_Front 62 - 384 C121S,C181S,C333S X221 0

SIK3 (Serine/threonine-protein kinase SIK3)

Group: CAMK
Total number of chains: 22
Spatial Dihedral Chains Representative
DFGin BLAminus 20 AF-Q9Y2K2-K1A
DFGin ABAminus 2 8R4VB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens SIK3_HUMAN 8R4VB 1.9 Inactive DFGin ABAminus out-out in-in XWA Type1 61 - 384 C121S,C181S,C333S X221 0
Homo sapiens SIK3_HUMAN 8R4VC 1.9 Inactive DFGin ABAminus out-out in-in XWA Type1 61 - 385 C121S,C181S,C333S X221 0
Homo sapiens SIK3_HUMAN AF-Q9Y2K2-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 58 - 325 None None 0
Homo sapiens SIK3_HUMAN 8R4OA 2.725 Active DFGin BLAminus in-in in-in XVI Type1 62 - 384 C121S,C181S,C333S X221 0
Homo sapiens SIK3_HUMAN 8R4OC 2.725 Active DFGin BLAminus in-in in-in XVI Type1 62 - 384 C121S,C181S,C333S X221 0
Homo sapiens SIK3_HUMAN 8R4OE 2.725 Active DFGin BLAminus in-in in-in XVI Type1 62 - 384 C121S,C181S,C333S X221 0
Homo sapiens SIK3_HUMAN 8R4OG 2.725 Active DFGin BLAminus in-in in-in XVI Type1 62 - 384 C121S,C181S,C333S X221 0
Homo sapiens SIK3_HUMAN 8R4OI 2.725 Active DFGin BLAminus in-in in-in XVI Type1 62 - 384 C121S,C181S,C333S X221 0
Homo sapiens SIK3_HUMAN 8R4OK 2.725 Active DFGin BLAminus in-in in-in XVI Type1 62 - 384 C121S,C181S,C333S X221 0
Homo sapiens SIK3_HUMAN 8R4QA 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1 62 - 384 C121S,C181S,C333S X221 0
Homo sapiens SIK3_HUMAN 8R4QC 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1 62 - 384 C121S,C181S,C333S X221 0
Homo sapiens SIK3_HUMAN 8R4QE 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1 62 - 384 C121S,C181S,C333S X221 0
Homo sapiens SIK3_HUMAN 8R4QG 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1 62 - 384 C121S,C181S,C333S X221 0
Homo sapiens SIK3_HUMAN 8R4QI 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1 62 - 384 C121S,C181S,C333S X221 0
Homo sapiens SIK3_HUMAN 8R4QK 2.838 Inactive DFGin BLAminus in-out in-in DB8 Type1 62 - 384 C121S,C181S,C333S X221 0
Homo sapiens SIK3_HUMAN 8R4VA 1.9 Inactive DFGin BLAminus out-out in-in XWA Type1 62 - 385 C121S,C181S,C333S X221 0
Homo sapiens SIK3_HUMAN 8OKUA 3.1 Active DFGin BLAminus in-in in-in VRU Type1 60 - 392 T221D None 0
Homo sapiens SIK3_HUMAN 8OKUB 3.1 Active DFGin BLAminus in-in in-in VRU Type1 60 - 390 T221D None 0
Homo sapiens SIK3_HUMAN 8R4UA 2.416 Inactive DFGin BLAminus in-out in-in XW3 Type1.5_Front 61 - 384 C121S,C181S,C333S X221 0
Homo sapiens SIK3_HUMAN 8R4UC 2.416 Inactive DFGin BLAminus in-out in-in XW3 Type1.5_Front 62 - 384 C121S,C181S,C333S X221 0
Homo sapiens SIK3_HUMAN 8R4UE 2.416 Inactive DFGin BLAminus in-out in-in XW3 Type1.5_Front 61 - 384 C121S,C181S,C333S X221 0
Homo sapiens SIK3_HUMAN 8R4UG 2.416 Inactive DFGin BLAminus in-out in-in XW3 Type1.5_Front 62 - 384 C121S,C181S,C333S X221 0

SIK3 (Serine/threonine-protein kinase SIK3)

No non-human structures known.