RET (Proto-oncogene tyrosine-protein kinase receptor Ret)

Group: TYR
Uniprot: RET_HUMAN
Domain boundary: 724 - 1007


Total number of chains: 37
Spatial Dihedral Chains Representative
DFGin BLAminus 37 AF-P07949-K1A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P07949-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 716 - 1015 None None 0
5AMNA 2.57 Active DFGin BLAminus in-in in-in DTQ Type1 705 - 1010 None X900,X905 0
6FEKA 2.3 None DFGin BLAminus in-none in-in ADN Type1 705 - 1010 S904F X900,X905 0
6I82A 2.05 Active DFGin BLAminus in-in in-in H6W Type1 705 - 1012 V804M X928 9
6I82B 2.05 Active DFGin BLAminus in-in in-in H6W Type1 714 - 1012 V804M X928 0
6I83A 1.88 Active DFGin BLAminus in-in in-in H72 Type1 705 - 1013 V804M X905 0
6VHGA 2.303 Active DFGin BLAminus in-in in-in QX1 Type1 707 - 1012 None X905,X928 0
2IVSA 2.0 Active DFGin BLAminus in-in in-in ACK Type1 713 - 1012 None None 0
2IVSB 2.0 Active DFGin BLAminus in-in in-in ACK Type1 703 - 1012 None None 11
2IVTA 2.6 Active DFGin BLAminus in-in in-in AMP Type1 703 - 1012 None X905 0
2IVUA 2.5 Active DFGin BLAminus in-in in-in ZD6 Type1 703 - 1012 None X905 0
2X2KA 2.6 Active DFGin BLAminus in-in in-in X2K Type1 703 - 1013 None X905 0
2X2LA 2.0 Active DFGin BLAminus in-in in-in X2L Type1 703 - 1010 None X905 0
2X2MA 2.5 Active DFGin BLAminus in-in in-in X2M Type1 703 - 1013 None X905 0
2X2MB 2.5 Active DFGin BLAminus in-in in-in X2M Type1 703 - 1011 None X905 0
4CKJA 1.65 Active DFGin BLAminus in-in in-in ADN Type1 705 - 1013 None X905 0
6NJAA 1.92 Active DFGin BLAminus in-in in-in ADE Type1 705 - 1013 None X900,X905 0
7DU9A 2.31 Active DFGin BLAminus in-in in-in Q4J Type1 714 - 1011 None None 0
7DU9B 2.31 Active DFGin BLAminus in-in in-in Q4J Type1 705 - 1012 None None 10
7JU5A 1.9 Active DFGin BLAminus in-in in-in Q4J Type1 705 - 1013 None None 8
7JU5B 1.9 Active DFGin BLAminus in-in in-in Q4J Type1 710 - 1012 None None 0
7JU6A 2.06 Active DFGin BLAminus in-in in-in Q6G Type1 713 - 1012 None None 0
7NZNA 2.39 Active DFGin BLAminus in-in in-in VJH Type1 705 - 1013 None X900,X905 0
2IVVA 2.25 Active DFGin BLAminus in-in in-in PP1 Type1 703 - 1011 None X905 0
5FM2A 3.3 Active DFGin BLAminus in-in in-in PP1 Type1 710 - 1011 None X809,X905,X909,X928 0
5FM3A 2.95 Active DFGin BLAminus in-in in-in PP1 Type1 707 - 1011 None X809,X905,X909,X928 0
6NE7A 1.99 Active DFGin BLAminus in-in in-in AMP Type1 705 - 1013 G810A X900,X905 0
4CKIA 2.116 Active DFGin BLAminus in-in in-in ADN Type1 705 - 1013 M918T X900,X905 0
6NECA 1.87 Active DFGin BLAminus in-in in-in XIN Type1.5_Back 713 - 1012 None None 0
6NECC 1.87 Active DFGin BLAminus in-in in-in XIN Type1.5_Back 705 - 1012 None None 9
7DUAA 1.64 Active DFGin BLAminus in-in in-in HJ0 Type1.5_Back 712 - 1011 None None 0
7DUAB 1.64 Active DFGin BLAminus in-in in-in HJ0 Type1.5_Back 705 - 1012 None None 10
7RUNA 3.51 Active DFGin BLAminus in-in in-in 7QU Type1.5_Back 705 - 1012 None X809,X905,X909,X928 0
7RUNB 3.51 Active DFGin BLAminus in-in in-in 7QU Type1.5_Back 706 - 1012 None X809,X905,X909,X928 0
7DU8A 2.75 Active DFGin BLAminus in-in in-in Q6G Type1.5_Front 714 - 1012 None None 0
7DU8B 2.75 Active DFGin BLAminus in-in in-in Q6G Type1.5_Front 705 - 1012 None None 10
7JU6B 2.06 Active DFGin BLAminus in-in in-in Q6G Type1.5_Front 705 - 1012 None None 9

RET (Proto-oncogene tyrosine-protein kinase receptor Ret)

Group: TYR
Total number of chains: 37
Spatial Dihedral Chains Representative
DFGin BLAminus 37 AF-P07949-K1A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens RET_HUMAN AF-P07949-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 716 - 1015 None None 0
Homo sapiens RET_HUMAN 5AMNA 2.57 Active DFGin BLAminus in-in in-in DTQ Type1 705 - 1010 None X900,X905 0
Homo sapiens RET_HUMAN 6FEKA 2.3 None DFGin BLAminus in-none in-in ADN Type1 705 - 1010 S904F X900,X905 0
Homo sapiens RET_HUMAN 6I82A 2.05 Active DFGin BLAminus in-in in-in H6W Type1 705 - 1012 V804M X928 9
Homo sapiens RET_HUMAN 6I82B 2.05 Active DFGin BLAminus in-in in-in H6W Type1 714 - 1012 V804M X928 0
Homo sapiens RET_HUMAN 6I83A 1.88 Active DFGin BLAminus in-in in-in H72 Type1 705 - 1013 V804M X905 0
Homo sapiens RET_HUMAN 6VHGA 2.303 Active DFGin BLAminus in-in in-in QX1 Type1 707 - 1012 None X905,X928 0
Homo sapiens RET_HUMAN 2IVSA 2.0 Active DFGin BLAminus in-in in-in ACK Type1 713 - 1012 None None 0
Homo sapiens RET_HUMAN 2IVSB 2.0 Active DFGin BLAminus in-in in-in ACK Type1 703 - 1012 None None 11
Homo sapiens RET_HUMAN 2IVTA 2.6 Active DFGin BLAminus in-in in-in AMP Type1 703 - 1012 None X905 0
Homo sapiens RET_HUMAN 2IVUA 2.5 Active DFGin BLAminus in-in in-in ZD6 Type1 703 - 1012 None X905 0
Homo sapiens RET_HUMAN 2X2KA 2.6 Active DFGin BLAminus in-in in-in X2K Type1 703 - 1013 None X905 0
Homo sapiens RET_HUMAN 2X2LA 2.0 Active DFGin BLAminus in-in in-in X2L Type1 703 - 1010 None X905 0
Homo sapiens RET_HUMAN 2X2MA 2.5 Active DFGin BLAminus in-in in-in X2M Type1 703 - 1013 None X905 0
Homo sapiens RET_HUMAN 2X2MB 2.5 Active DFGin BLAminus in-in in-in X2M Type1 703 - 1011 None X905 0
Homo sapiens RET_HUMAN 4CKJA 1.65 Active DFGin BLAminus in-in in-in ADN Type1 705 - 1013 None X905 0
Homo sapiens RET_HUMAN 6NJAA 1.92 Active DFGin BLAminus in-in in-in ADE Type1 705 - 1013 None X900,X905 0
Homo sapiens RET_HUMAN 7DU9A 2.31 Active DFGin BLAminus in-in in-in Q4J Type1 714 - 1011 None None 0
Homo sapiens RET_HUMAN 7DU9B 2.31 Active DFGin BLAminus in-in in-in Q4J Type1 705 - 1012 None None 10
Homo sapiens RET_HUMAN 7JU5A 1.9 Active DFGin BLAminus in-in in-in Q4J Type1 705 - 1013 None None 8
Homo sapiens RET_HUMAN 7JU5B 1.9 Active DFGin BLAminus in-in in-in Q4J Type1 710 - 1012 None None 0
Homo sapiens RET_HUMAN 7JU6A 2.06 Active DFGin BLAminus in-in in-in Q6G Type1 713 - 1012 None None 0
Homo sapiens RET_HUMAN 7NZNA 2.39 Active DFGin BLAminus in-in in-in VJH Type1 705 - 1013 None X900,X905 0
Homo sapiens RET_HUMAN 2IVVA 2.25 Active DFGin BLAminus in-in in-in PP1 Type1 703 - 1011 None X905 0
Homo sapiens RET_HUMAN 5FM2A 3.3 Active DFGin BLAminus in-in in-in PP1 Type1 710 - 1011 None X809,X905,X909,X928 0
Homo sapiens RET_HUMAN 5FM3A 2.95 Active DFGin BLAminus in-in in-in PP1 Type1 707 - 1011 None X809,X905,X909,X928 0
Homo sapiens RET_HUMAN 6NE7A 1.99 Active DFGin BLAminus in-in in-in AMP Type1 705 - 1013 G810A X900,X905 0
Homo sapiens RET_HUMAN 4CKIA 2.116 Active DFGin BLAminus in-in in-in ADN Type1 705 - 1013 M918T X900,X905 0
Homo sapiens RET_HUMAN 6NECA 1.87 Active DFGin BLAminus in-in in-in XIN Type1.5_Back 713 - 1012 None None 0
Homo sapiens RET_HUMAN 6NECC 1.87 Active DFGin BLAminus in-in in-in XIN Type1.5_Back 705 - 1012 None None 9
Homo sapiens RET_HUMAN 7DUAA 1.64 Active DFGin BLAminus in-in in-in HJ0 Type1.5_Back 712 - 1011 None None 0
Homo sapiens RET_HUMAN 7DUAB 1.64 Active DFGin BLAminus in-in in-in HJ0 Type1.5_Back 705 - 1012 None None 10
Homo sapiens RET_HUMAN 7RUNA 3.51 Active DFGin BLAminus in-in in-in 7QU Type1.5_Back 705 - 1012 None X809,X905,X909,X928 0
Homo sapiens RET_HUMAN 7RUNB 3.51 Active DFGin BLAminus in-in in-in 7QU Type1.5_Back 706 - 1012 None X809,X905,X909,X928 0
Homo sapiens RET_HUMAN 7DU8A 2.75 Active DFGin BLAminus in-in in-in Q6G Type1.5_Front 714 - 1012 None None 0
Homo sapiens RET_HUMAN 7DU8B 2.75 Active DFGin BLAminus in-in in-in Q6G Type1.5_Front 705 - 1012 None None 10
Homo sapiens RET_HUMAN 7JU6B 2.06 Active DFGin BLAminus in-in in-in Q6G Type1.5_Front 705 - 1012 None None 9

RET (Proto-oncogene tyrosine-protein kinase receptor Ret)

No non-human structures known.