MAPK8 (Mitogen-activated protein kinase 8)

Group: CMGC
Uniprot: MK08_HUMAN
Domain boundary: 26 - 321


Total number of chains: 61
Spatial Dihedral Chains Representative
DFGin BLAminus 20 AF-P45983-K1A
DFGin ABAminus 38 8R5EA
DFGin None 3 2G01B
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
1UKHA 2.35 Inactive DFGin ABAminus in-in none-none No_ligand No_ligand 9 - 363 None None 17
4YR8A 2.4 Inactive DFGin ABAminus in-in none-out No_ligand No_ligand 8 - 362 None None 13
4YR8C 2.4 Inactive DFGin ABAminus in-in none-none No_ligand No_ligand 10 - 362 None None 16
4YR8E 2.4 Inactive DFGin ABAminus out-out out-out No_ligand No_ligand 7 - 362 None None 12
4YR8F 2.4 Inactive DFGin ABAminus in-in none-none No_ligand No_ligand 10 - 362 None None 16
6F5EB 2.7 Inactive DFGin ABAminus in-in out-out No_ligand No_ligand 7 - 362 None None 4
8X5MA 2.0 Inactive DFGin ABAminus in-in out-out Y4O Type1 7 - 363 None None 12
6ZR5A 2.699 Inactive DFGin ABAminus out-out out-none ANP Type1 3 - 362 None None 12
6ZR5B 2.699 Inactive DFGin ABAminus out-out out-out ANP Type1 4 - 362 None None 0
8PT8A 2.78 Inactive DFGin ABAminus in-out in-out A3O Type1 7 - 363 None None 2
8PT8B 2.78 Inactive DFGin ABAminus out-out out-out A3O Type1 8 - 363 None None 0
8PT8C 2.78 Inactive DFGin ABAminus in-out out-out A3O Type1 7 - 362 None None 3
8PT9A 2.7 Inactive DFGin ABAminus out-in out-out DVI Type1 8 - 363 None None 2
8PT9B 2.7 Inactive DFGin ABAminus in-out none-out DVI Type1 7 - 363 None None 5
8PT9C 2.7 Inactive DFGin ABAminus out-out out-out DVI Type1 8 - 362 None None 3
8PTAA 2.41 Inactive DFGin ABAminus in-in out-out CIF Type1 8 - 363 None None 2
8PTAB 2.41 Inactive DFGin ABAminus in-in none-out CIF Type1 7 - 363 None None 5
8PTAC 2.41 Inactive DFGin ABAminus in-out out-out CIF Type1 8 - 361 None None 3
1UKIA 2.7 Inactive DFGin ABAminus in-in out-none 537 Type1 9 - 363 None None 13
4E73A 2.27 Inactive DFGin ABAminus in-in none-none 0NR Type1 8 - 361 None None 15
4G1WA 2.45 Inactive DFGin ABAminus in-in none-none G1W Type1 8 - 361 None None 15
4HYSA 2.415 Inactive DFGin ABAminus in-in none-none 1BJ Type1 8 - 361 None None 15
4HYUA 2.152 Inactive DFGin ABAminus in-in none-none 1BK Type1 8 - 361 None None 15
4IZYA 2.3 Inactive DFGin ABAminus in-in none-none 1J2 Type1 8 - 361 None None 15
2XRWA 1.33 Inactive DFGin ABAminus in-out none-none ANP Type1 2 - 364 None None 16
2XS0A 2.6 Inactive DFGin ABAminus in-out none-none ANP Type1 6 - 365 T183V,Y185F None 14
3PZEA 2.0 Inactive DFGin ABAminus in-in none-out CFK Type1 7 - 362 None None 9
4UX9A 2.34 Inactive DFGin ABAminus in-out in-in ANP Type1 8 - 363 None None 5
4UX9C 2.34 Inactive DFGin ABAminus in-out in-in ANP Type1 8 - 363 None None 7
4UX9D 2.34 Inactive DFGin ABAminus in-in in-out ANP Type1 9 - 364 None None 0
4L7FA 1.95 Inactive DFGin ABAminus in-in none-out 1V5 Type1 7 - 362 None None 13
3ELJA 1.8 Inactive DFGin ABAminus in-in none-out GS7 Type1 7 - 364 None None 6
4AWIA 1.91 Inactive DFGin ABAminus in-in none-out AQ2 Type1 8 - 364 None None 5
5LW1B 3.2 Inactive DFGin ABAminus out-out out-out ADN Type1 8 - 362 None None 0
5LW1E 3.2 Inactive DFGin ABAminus in-out out-out ADN Type1 8 - 362 None None 0
5LW1H 3.2 Inactive DFGin ABAminus out-out out-out ADN Type1 8 - 362 None None 0
8R5EA 1.7 Inactive DFGin ABAminus in-out out-out ANP Y6K Type1 Allosteric 5 - 363 None None 0
4QTDA 1.5 Inactive DFGin ABAminus in-out out-out 38Z ANP Type1 Allosteric 6 - 363 None None 3
3O2MA 2.7 Active DFGin BLAminus in-in in-in 46A Allosteric 7 - 364 T183E,Y185E None 0
3O2MB 2.7 Active DFGin BLAminus in-in in-in 46A Allosteric 7 - 364 T183E,Y185E None 0
3VULA 2.81 None DFGin BLAminus in-in in-none No_ligand No_ligand 7 - 364 C79V,C116S,C137V,C163A,C213V,C245S None 14
3VUIA 2.8 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 364 C79V,C116S,C163A,C245S None 3
3VUHA 2.7 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 364 C116S,C163A,C245S None 3
3VUDA 3.5 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 364 C245S None 3
3VUGA 3.24 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 364 C116S,C245S None 3
3VUKA 2.95 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 364 C79V,C116S,C137V,C163A,C245S None 3
3VUMA 2.69 None DFGin BLAminus in-in in-none No_ligand No_ligand 7 - 364 C41V,C79V,C116S,C137V,C163A,C213V,C245S None 14
AF-P45983-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 18 - 329 None None 0
3O17A 3.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 363 T183E,Y185E None 0
3O17B 3.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 363 T183E,Y185E None 0
3V3VA 2.7 Active DFGin BLAminus in-in in-in MYU Type1 7 - 363 None None 4
9FT9A 2.35 Inactive DFGin BLAminus in-out in-out ANP Type1 7 - 363 None None 0
2G01A 3.5 Active DFGin BLAminus out-in in-in 73Q Type1 10 - 364 T183E,Y185E None 0
2GMXA 3.5 Active DFGin BLAminus in-in in-in 877 Type1 8 - 364 T183E,Y185E None 0
2H96A 3.0 Active DFGin BLAminus in-in in-in 893 Type1 7 - 364 T183E,Y185E None 0
2H96B 3.0 Active DFGin BLAminus in-in in-in 893 Type1 7 - 364 T183E,Y185E None 0
2NO3A 3.2 Active DFGin BLAminus in-in in-in 859 Type1 8 - 364 T183E,Y185E None 0
2NO3B 3.2 Active DFGin BLAminus in-in in-in 859 Type1 7 - 363 T183E,Y185E None 0
4UX9B 2.34 Inactive DFGin None in-in in-in ANP Type1 8 - 362 None None 6
2G01B 3.5 Inactive DFGin None in-in in-in 73Q Type1 9 - 364 T183E,Y185E None 0
2GMXB 3.5 Inactive DFGin None in-out in-in 877 Type1 7 - 364 T183E,Y185E None 0

MAPK8 (Mitogen-activated protein kinase 8)

Group: CMGC
Total number of chains: 61
Spatial Dihedral Chains Representative
DFGin BLAminus 20 AF-P45983-K1A
DFGin ABAminus 38 8R5EA
DFGin None 3 2G01B
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens MK08_HUMAN 1UKHA 2.35 Inactive DFGin ABAminus in-in none-none No_ligand No_ligand 9 - 363 None None 17
Homo sapiens MK08_HUMAN 4YR8A 2.4 Inactive DFGin ABAminus in-in none-out No_ligand No_ligand 8 - 362 None None 13
Homo sapiens MK08_HUMAN 4YR8C 2.4 Inactive DFGin ABAminus in-in none-none No_ligand No_ligand 10 - 362 None None 16
Homo sapiens MK08_HUMAN 4YR8E 2.4 Inactive DFGin ABAminus out-out out-out No_ligand No_ligand 7 - 362 None None 12
Homo sapiens MK08_HUMAN 4YR8F 2.4 Inactive DFGin ABAminus in-in none-none No_ligand No_ligand 10 - 362 None None 16
Homo sapiens MK08_HUMAN 6F5EB 2.7 Inactive DFGin ABAminus in-in out-out No_ligand No_ligand 7 - 362 None None 4
Homo sapiens MK08_HUMAN 8X5MA 2.0 Inactive DFGin ABAminus in-in out-out Y4O Type1 7 - 363 None None 12
Homo sapiens MK08_HUMAN 6ZR5A 2.699 Inactive DFGin ABAminus out-out out-none ANP Type1 3 - 362 None None 12
Homo sapiens MK08_HUMAN 6ZR5B 2.699 Inactive DFGin ABAminus out-out out-out ANP Type1 4 - 362 None None 0
Homo sapiens MK08_HUMAN 8PT8A 2.78 Inactive DFGin ABAminus in-out in-out A3O Type1 7 - 363 None None 2
Homo sapiens MK08_HUMAN 8PT8B 2.78 Inactive DFGin ABAminus out-out out-out A3O Type1 8 - 363 None None 0
Homo sapiens MK08_HUMAN 8PT8C 2.78 Inactive DFGin ABAminus in-out out-out A3O Type1 7 - 362 None None 3
Homo sapiens MK08_HUMAN 8PT9A 2.7 Inactive DFGin ABAminus out-in out-out DVI Type1 8 - 363 None None 2
Homo sapiens MK08_HUMAN 8PT9B 2.7 Inactive DFGin ABAminus in-out none-out DVI Type1 7 - 363 None None 5
Homo sapiens MK08_HUMAN 8PT9C 2.7 Inactive DFGin ABAminus out-out out-out DVI Type1 8 - 362 None None 3
Homo sapiens MK08_HUMAN 8PTAA 2.41 Inactive DFGin ABAminus in-in out-out CIF Type1 8 - 363 None None 2
Homo sapiens MK08_HUMAN 8PTAB 2.41 Inactive DFGin ABAminus in-in none-out CIF Type1 7 - 363 None None 5
Homo sapiens MK08_HUMAN 8PTAC 2.41 Inactive DFGin ABAminus in-out out-out CIF Type1 8 - 361 None None 3
Homo sapiens MK08_HUMAN 1UKIA 2.7 Inactive DFGin ABAminus in-in out-none 537 Type1 9 - 363 None None 13
Homo sapiens MK08_HUMAN 4E73A 2.27 Inactive DFGin ABAminus in-in none-none 0NR Type1 8 - 361 None None 15
Homo sapiens MK08_HUMAN 4G1WA 2.45 Inactive DFGin ABAminus in-in none-none G1W Type1 8 - 361 None None 15
Homo sapiens MK08_HUMAN 4HYSA 2.415 Inactive DFGin ABAminus in-in none-none 1BJ Type1 8 - 361 None None 15
Homo sapiens MK08_HUMAN 4HYUA 2.152 Inactive DFGin ABAminus in-in none-none 1BK Type1 8 - 361 None None 15
Homo sapiens MK08_HUMAN 4IZYA 2.3 Inactive DFGin ABAminus in-in none-none 1J2 Type1 8 - 361 None None 15
Homo sapiens MK08_HUMAN 2XRWA 1.33 Inactive DFGin ABAminus in-out none-none ANP Type1 2 - 364 None None 16
Homo sapiens MK08_HUMAN 2XS0A 2.6 Inactive DFGin ABAminus in-out none-none ANP Type1 6 - 365 T183V,Y185F None 14
Homo sapiens MK08_HUMAN 3PZEA 2.0 Inactive DFGin ABAminus in-in none-out CFK Type1 7 - 362 None None 9
Homo sapiens MK08_HUMAN 4UX9A 2.34 Inactive DFGin ABAminus in-out in-in ANP Type1 8 - 363 None None 5
Homo sapiens MK08_HUMAN 4UX9C 2.34 Inactive DFGin ABAminus in-out in-in ANP Type1 8 - 363 None None 7
Homo sapiens MK08_HUMAN 4UX9D 2.34 Inactive DFGin ABAminus in-in in-out ANP Type1 9 - 364 None None 0
Homo sapiens MK08_HUMAN 4L7FA 1.95 Inactive DFGin ABAminus in-in none-out 1V5 Type1 7 - 362 None None 13
Homo sapiens MK08_HUMAN 3ELJA 1.8 Inactive DFGin ABAminus in-in none-out GS7 Type1 7 - 364 None None 6
Homo sapiens MK08_HUMAN 4AWIA 1.91 Inactive DFGin ABAminus in-in none-out AQ2 Type1 8 - 364 None None 5
Homo sapiens MK08_HUMAN 5LW1B 3.2 Inactive DFGin ABAminus out-out out-out ADN Type1 8 - 362 None None 0
Homo sapiens MK08_HUMAN 5LW1E 3.2 Inactive DFGin ABAminus in-out out-out ADN Type1 8 - 362 None None 0
Homo sapiens MK08_HUMAN 5LW1H 3.2 Inactive DFGin ABAminus out-out out-out ADN Type1 8 - 362 None None 0
Homo sapiens MK08_HUMAN 8R5EA 1.7 Inactive DFGin ABAminus in-out out-out ANP Y6K Type1 Allosteric 5 - 363 None None 0
Homo sapiens MK08_HUMAN 4QTDA 1.5 Inactive DFGin ABAminus in-out out-out 38Z ANP Type1 Allosteric 6 - 363 None None 3
Homo sapiens MK08_HUMAN 3O2MA 2.7 Active DFGin BLAminus in-in in-in 46A Allosteric 7 - 364 T183E,Y185E None 0
Homo sapiens MK08_HUMAN 3O2MB 2.7 Active DFGin BLAminus in-in in-in 46A Allosteric 7 - 364 T183E,Y185E None 0
Homo sapiens MK08_HUMAN 3VULA 2.81 None DFGin BLAminus in-in in-none No_ligand No_ligand 7 - 364 C79V,C116S,C137V,C163A,C213V,C245S None 14
Homo sapiens MK08_HUMAN 3VUIA 2.8 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 364 C79V,C116S,C163A,C245S None 3
Homo sapiens MK08_HUMAN 3VUHA 2.7 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 364 C116S,C163A,C245S None 3
Homo sapiens MK08_HUMAN 3VUDA 3.5 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 364 C245S None 3
Homo sapiens MK08_HUMAN 3VUGA 3.24 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 364 C116S,C245S None 3
Homo sapiens MK08_HUMAN 3VUKA 2.95 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 364 C79V,C116S,C137V,C163A,C245S None 3
Homo sapiens MK08_HUMAN 3VUMA 2.69 None DFGin BLAminus in-in in-none No_ligand No_ligand 7 - 364 C41V,C79V,C116S,C137V,C163A,C213V,C245S None 14
Homo sapiens MK08_HUMAN AF-P45983-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 18 - 329 None None 0
Homo sapiens MK08_HUMAN 3O17A 3.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 363 T183E,Y185E None 0
Homo sapiens MK08_HUMAN 3O17B 3.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 363 T183E,Y185E None 0
Homo sapiens MK08_HUMAN 3V3VA 2.7 Active DFGin BLAminus in-in in-in MYU Type1 7 - 363 None None 4
Homo sapiens MK08_HUMAN 9FT9A 2.35 Inactive DFGin BLAminus in-out in-out ANP Type1 7 - 363 None None 0
Homo sapiens MK08_HUMAN 2G01A 3.5 Active DFGin BLAminus out-in in-in 73Q Type1 10 - 364 T183E,Y185E None 0
Homo sapiens MK08_HUMAN 2GMXA 3.5 Active DFGin BLAminus in-in in-in 877 Type1 8 - 364 T183E,Y185E None 0
Homo sapiens MK08_HUMAN 2H96A 3.0 Active DFGin BLAminus in-in in-in 893 Type1 7 - 364 T183E,Y185E None 0
Homo sapiens MK08_HUMAN 2H96B 3.0 Active DFGin BLAminus in-in in-in 893 Type1 7 - 364 T183E,Y185E None 0
Homo sapiens MK08_HUMAN 2NO3A 3.2 Active DFGin BLAminus in-in in-in 859 Type1 8 - 364 T183E,Y185E None 0
Homo sapiens MK08_HUMAN 2NO3B 3.2 Active DFGin BLAminus in-in in-in 859 Type1 7 - 363 T183E,Y185E None 0
Homo sapiens MK08_HUMAN 4UX9B 2.34 Inactive DFGin None in-in in-in ANP Type1 8 - 362 None None 6
Homo sapiens MK08_HUMAN 2G01B 3.5 Inactive DFGin None in-in in-in 73Q Type1 9 - 364 T183E,Y185E None 0
Homo sapiens MK08_HUMAN 2GMXB 3.5 Inactive DFGin None in-out in-in 877 Type1 7 - 364 T183E,Y185E None 0

MAPK8 (Mitogen-activated protein kinase 8)

No non-human structures known.