TNIK (TRAF2 and NCK-interacting protein kinase)

Group: STE
Uniprot: TNIK_HUMAN
Domain boundary: 25 - 289


Total number of chains: 24
Spatial Dihedral Chains Representative
DFGin BLAminus 15 AF-Q9UKE5-K1A
DFGin BLBplus 6 5D7AA
DFGin None 1 2X7FE
DFGinter None 2 8X88A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q9UKE5-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 17 - 297 None None 0
6RA5B 2.9 None DFGin BLAminus in-none in-in No_ligand No_ligand 14 - 310 None X181,X187 7
7XZQA 2.09 Active DFGin BLAminus in-in in-in No_ligand No_ligand 11 - 310 None X181,X187 0
6RA5A 2.9 Active DFGin BLAminus in-in in-in JWE Type1 12 - 309 None X181,X187 0
6RA7A 1.2 Active DFGin BLAminus in-in in-in JWK Type1 13 - 314 None X181,X187 0
7XZRB 2.26 Active DFGin BLAminus in-in in-in ANP Type1 12 - 312 None X181,X187 0
8WM0A 2.8 Active DFGin BLAminus in-in in-in ADN Type1 12 - 310 None X181,X187 0
5AX9A 2.4 None DFGin BLAminus in-in none-out 4KT Type1 12 - 307 None None 14
5AX9B 2.4 Active DFGin BLAminus in-in in-in 4KT Type1 13 - 307 None None 12
5AX9C 2.4 Inactive DFGin BLAminus in-in in-out 4KT Type1 12 - 309 None None 12
2X7FA 2.8 None DFGin BLAminus in-none out-out 824 Type1 15 - 313 None None 13
2X7FB 2.8 None DFGin BLAminus in-none out-out 824 Type1 13 - 313 None None 12
2X7FC 2.8 None DFGin BLAminus in-none out-none 824 Type1 14 - 313 None None 14
2X7FD 2.8 None DFGin BLAminus in-none none-none 824 Type1 17 - 306 None None 15
7XZRA 2.26 Active DFGin BLAminus in-in in-in ANP Type1.5_Front 12 - 310 None X181,X187 0
5CWZA 2.9 Inactive DFGin BLBplus in-out none-out No_ligand No_ligand 11 - 307 None None 11
5CWZB 2.9 Inactive DFGin BLBplus in-out none-out No_ligand No_ligand 11 - 307 None None 11
5CWZC 2.9 Inactive DFGin BLBplus in-in none-out No_ligand No_ligand 15 - 308 None None 15
5D7AA 2.9 Inactive DFGin BLBplus in-out none-out 58C Type1 11 - 310 None None 11
5D7AB 2.9 Inactive DFGin BLBplus in-out none-out 58C Type1 11 - 307 None None 11
5D7AC 2.9 Inactive DFGin BLBplus in-in none-out 58C Type1 13 - 310 None None 12
2X7FE 2.8 Inactive DFGin None in-none none-none 824 Type1 14 - 309 None None 18
8X88A 2.7 Inactive DFGinter None out-out out-out No_ligand No_ligand 15 - 311 None None 3
8X88B 2.7 Inactive DFGinter None out-out out-out No_ligand No_ligand 17 - 311 None None 0

TNIK (TRAF2 and NCK-interacting protein kinase)

Group: STE
Total number of chains: 24
Spatial Dihedral Chains Representative
DFGin BLAminus 15 AF-Q9UKE5-K1A
DFGin BLBplus 6 5D7AA
DFGin None 1 2X7FE
DFGinter None 2 8X88A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens TNIK_HUMAN AF-Q9UKE5-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 17 - 297 None None 0
Homo sapiens TNIK_HUMAN 6RA5B 2.9 None DFGin BLAminus in-none in-in No_ligand No_ligand 14 - 310 None X181,X187 7
Homo sapiens TNIK_HUMAN 7XZQA 2.09 Active DFGin BLAminus in-in in-in No_ligand No_ligand 11 - 310 None X181,X187 0
Homo sapiens TNIK_HUMAN 6RA5A 2.9 Active DFGin BLAminus in-in in-in JWE Type1 12 - 309 None X181,X187 0
Homo sapiens TNIK_HUMAN 6RA7A 1.2 Active DFGin BLAminus in-in in-in JWK Type1 13 - 314 None X181,X187 0
Homo sapiens TNIK_HUMAN 7XZRB 2.26 Active DFGin BLAminus in-in in-in ANP Type1 12 - 312 None X181,X187 0
Homo sapiens TNIK_HUMAN 8WM0A 2.8 Active DFGin BLAminus in-in in-in ADN Type1 12 - 310 None X181,X187 0
Homo sapiens TNIK_HUMAN 5AX9A 2.4 None DFGin BLAminus in-in none-out 4KT Type1 12 - 307 None None 14
Homo sapiens TNIK_HUMAN 5AX9B 2.4 Active DFGin BLAminus in-in in-in 4KT Type1 13 - 307 None None 12
Homo sapiens TNIK_HUMAN 5AX9C 2.4 Inactive DFGin BLAminus in-in in-out 4KT Type1 12 - 309 None None 12
Homo sapiens TNIK_HUMAN 2X7FA 2.8 None DFGin BLAminus in-none out-out 824 Type1 15 - 313 None None 13
Homo sapiens TNIK_HUMAN 2X7FB 2.8 None DFGin BLAminus in-none out-out 824 Type1 13 - 313 None None 12
Homo sapiens TNIK_HUMAN 2X7FC 2.8 None DFGin BLAminus in-none out-none 824 Type1 14 - 313 None None 14
Homo sapiens TNIK_HUMAN 2X7FD 2.8 None DFGin BLAminus in-none none-none 824 Type1 17 - 306 None None 15
Homo sapiens TNIK_HUMAN 7XZRA 2.26 Active DFGin BLAminus in-in in-in ANP Type1.5_Front 12 - 310 None X181,X187 0
Homo sapiens TNIK_HUMAN 5CWZA 2.9 Inactive DFGin BLBplus in-out none-out No_ligand No_ligand 11 - 307 None None 11
Homo sapiens TNIK_HUMAN 5CWZB 2.9 Inactive DFGin BLBplus in-out none-out No_ligand No_ligand 11 - 307 None None 11
Homo sapiens TNIK_HUMAN 5CWZC 2.9 Inactive DFGin BLBplus in-in none-out No_ligand No_ligand 15 - 308 None None 15
Homo sapiens TNIK_HUMAN 5D7AA 2.9 Inactive DFGin BLBplus in-out none-out 58C Type1 11 - 310 None None 11
Homo sapiens TNIK_HUMAN 5D7AB 2.9 Inactive DFGin BLBplus in-out none-out 58C Type1 11 - 307 None None 11
Homo sapiens TNIK_HUMAN 5D7AC 2.9 Inactive DFGin BLBplus in-in none-out 58C Type1 13 - 310 None None 12
Homo sapiens TNIK_HUMAN 2X7FE 2.8 Inactive DFGin None in-none none-none 824 Type1 14 - 309 None None 18
Homo sapiens TNIK_HUMAN 8X88A 2.7 Inactive DFGinter None out-out out-out No_ligand No_ligand 15 - 311 None None 3
Homo sapiens TNIK_HUMAN 8X88B 2.7 Inactive DFGinter None out-out out-out No_ligand No_ligand 17 - 311 None None 0

TNIK (TRAF2 and NCK-interacting protein kinase)

No non-human structures known.