KinCore

OTHER_TTK (Dual specificity protein kinase TTK)

Total number of chains: 78

Active chains: 1

Uniprot: TTK_HUMAN

Kinase Domain Residues: 525 - 791

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	ABAminus	74	94.9%	5AP1A
DFGin	BLAminus	2	2.6%	AF-P33981-K3A
DFGin	BLAplus	1	1.3%	3H9FA
DFGin	None	1	1.3%	7CHMA

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Gene	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
TTK	AF-P33981-K3A	P33981	517	799	857.0	No_ligand	No_ligand	Active	DFGin	6.3009	15.0197	BLAminus	-134.12, 174.57	65.6, 59.77	-77.34, 9.88	287.47, 86.26	-59.03, -34.57	in-in	in	8.3972	Saltbr-in	2.6594	HRD-in	-73.18, -39.18	69.58, 0.64	in-in-in	SNCiii	in-in	ActLoopNT-in	2.8261	ActLoopCT-in	nonTYR	APEdihe_aaiii	APEdist_iiii	APE10-dihe-na	-135.89, 143.68	APE9-dihe-na	107.15, 164.37	APE8-dihe-in	-93.15, 118.3	APE8-rot-in	301.9	APE67-dihe-in	-66.11, -12.59	-45.21, -41.73	APE12-dist-in	9.3194	APE11-dist-in	11.1231	APE10-dist-in	5.4736	APE9-dist-in	3.5477	None	None	None	AF2	-1.0	1.0	1.0	A	283.0	283.0	0	30	30	0	[[525, 791]]	1.0	AF-P33981-K3	OTHER_TTK_HUMAN	CAMK	5.7e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	3HMNA	P33981	516	794	857.0	ATP:1	ATPlike	Inactive	DFGin	3.9993	14.9908	ABAminus	-98.05, -9.81	-153.31, 160.67	-110.5, 6.35	307.22, 150.55	69.66, 19.48	out-out	out	10.962	Saltbr-out	6.5276	HRD-in	-68.45, -50.57	72.29, 2.18	out-out-out	SNCooo	out-out	ActLoopNT-out	11.6458	ActLoopCT-out	nonTYR	APEdihe_aaiii	APEdist_nnoo	APE10-dihe-na	999.0, 102.39	APE9-dihe-na	-78.34, -151.63	APE8-dihe-in	-168.7, 144.18	APE8-rot-in	299.37	APE67-dihe-in	-66.82, -19.22	-122.77, 14.51	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	20.6219	APE9-dist-out	12.1907	None	None	None	XRAY	2.7	0.223	0.265	A	342.0	255.0	24	30	18	12	[[525, 791]]	1.0	3hmn	OTHER_TTK_HUMAN	CAMK	1.1e-53	188.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	3CEKA	P33981	519	794	857.0	No_ligand	No_ligand	Inactive	DFGin	4.1477	15.0877	ABAminus	-98.03, -14.36	-147.33, 142.24	-107.5, -0.94	300.98, 162.57	82.4, 8.93	out-out	out	11.1014	Saltbr-out	6.5727	HRD-in	-63.8, -55.54	78.98, -2.7	out-out-out	SNCooo	out-out	ActLoopNT-out	10.6408	ActLoopCT-out	nonTYR	APEdihe_aaoni	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, -140.03	APE8-dihe-out	-135.87, -42.68	APE8-rot-none	999.0	APE67-dihe-in	-70.42, -22.06	-66.07, -16.05	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	13.2773	None	None	None	XRAY	2.3	0.188	0.25	A	313.0	252.0	24	30	16	14	[[525, 791]]	1.0	3cek	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	3DBQA	P33981	515	796	857.0	No_ligand	No_ligand	Inactive	DFGin	4.218	15.6259	ABAminus	-82.17, -30.42	-141.36, 167.61	-106.63, 0.96	290.84, 175.03	70.86, 9.96	out-out	out	10.3514	Saltbr-out	6.591	HRD-in	-57.38, -50.92	66.46, 1.19	out-out-out	SNCooo	out-out	ActLoopNT-out	11.2541	ActLoopCT-out	nonTYR	APEdihe_aaiii	APEdist_nnoo	APE10-dihe-na	999.0, 166.38	APE9-dihe-na	117.73, 69.71	APE8-dihe-in	-75.54, 158.78	APE8-rot-in	302.2	APE67-dihe-in	-74.9, -25.39	-128.59, 17.55	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	18.7884	APE9-dist-out	11.7206	None	None	None	XRAY	2.7	0.226	0.285	A	343.0	259.0	23	30	18	12	[[525, 791]]	1.0	3dbq	OTHER_TTK_HUMAN	CAMK	1.1e-53	188.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	2ZMCA	P33981	516	794	857.0	No_ligand	No_ligand	Inactive	DFGin	4.045	15.3608	ABAminus	-102.63, 6.43	-172.08, 140.67	-107.12, 4.47	303.66, 149.3	60.1, 32.65	out-out	out	11.3165	Saltbr-out	5.811	HRD-in	-51.44, -51.77	70.45, 12.69	out-out-out	SNCooo	out-out	ActLoopNT-out	10.588	ActLoopCT-out	nonTYR	APEdihe_aaiii	APEdist_oooo	APE10-dihe-na	-148.16, 52.12	APE9-dihe-na	-110.91, 95.2	APE8-dihe-in	-78.12, 144.82	APE8-rot-in	328.93	APE67-dihe-in	-59.32, -21.8	-101.22, 8.95	APE12-dist-out	22.842	APE11-dist-out	21.0107	APE10-dist-out	19.4959	APE9-dist-out	11.4538	None	None	None	XRAY	3.14	0.226	0.289	A	390.0	260.0	19	30	21	9	[[525, 791]]	1.0	2zmc	OTHER_TTK_HUMAN	CAMK	1.7e-53	187.6	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	6GVJA	P33981	515	795	857.0	No_ligand	No_ligand	Inactive	DFGin	4.1899	15.3859	ABAminus	-94.09, -39.51	-142.2, 169.22	-115.27, 12.46	297.03, 156.51	66.91, 11.36	out-out	out	10.7254	Saltbr-out	9.2857	HRD-in	-64.5, -59.44	84.15, 4.87	out-out-out	SNCooo	out-out	ActLoopNT-out	11.8119	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_oooo	APE10-dihe-na	-96.72, 154.33	APE9-dihe-na	116.29, 95.4	APE8-dihe-in	-94.84, 145.96	APE8-rot-out	191.9	APE67-dihe-in	-63.51, -23.75	-95.29, 10.45	APE12-dist-out	22.0995	APE11-dist-out	23.6125	APE10-dist-out	18.8371	APE9-dist-out	11.483	None	None	None	XRAY	2.41	0.203	0.233	A	429.0	272.0	9	30	30	0	[[525, 791]]	1.0	6gvj	OTHER_TTK_HUMAN	CAMK	2.3e-53	187.2	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5NTTA	P33981	519	797	857.0	SVE:60801	Type1	Inactive	DFGin	4.0498	15.1203	ABAminus	-86.34, -42.9	-137.69, 167.25	-111.84, 11.03	299.57, 162.1	66.85, 16.85	out-out	out	10.9798	Saltbr-out	5.9222	HRD-in	-63.1, -49.38	74.04, 9.83	out-out-out	SNCooo	out-out	ActLoopNT-out	11.5008	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_oooo	APE10-dihe-na	-72.45, -49.0	APE9-dihe-na	-71.51, -26.39	APE8-dihe-in	-34.25, 137.42	APE8-rot-none	999.0	APE67-dihe-in	-68.38, -17.02	-109.78, 8.89	APE12-dist-out	22.2734	APE11-dist-out	18.5318	APE10-dist-out	15.6898	APE9-dist-out	11.5508	C604Y	TPO686	TPO686	XRAY	2.75	0.201	0.23	A	287.0	269.0	10	30	30	0	[[525, 791]]	1.0	5ntt	OTHER_TTK_HUMAN	CAMK	4.2e-54	189.5	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5LJJA	P33981	519	795	857.0	AD5:60901	Type1	Inactive	DFGin	4.3299	14.8533	ABAminus	-81.43, -35.19	-129.4, 134.9	-96.53, 6.93	283.88, 13.64	82.2, 19.77	out-out	out	10.0606	Saltbr-out	3.967	HRD-in	-54.64, -37.72	72.33, -52.21	out-out-out	SNCooo	out-out	ActLoopNT-out	12.1379	ActLoopCT-out	nonTYR	APEdihe_aaoii	APEdist_oooo	APE10-dihe-na	-74.59, 157.14	APE9-dihe-na	-95.35, -179.33	APE8-dihe-out	-73.32, -32.03	APE8-rot-in	319.71	APE67-dihe-in	-53.22, -30.68	-79.48, -20.83	APE12-dist-out	22.5363	APE11-dist-out	24.5732	APE10-dist-out	19.8838	APE9-dist-out	14.0722	C604Y	None	None	XRAY	3.0	0.228	0.268	A	313.0	260.0	17	30	25	5	[[525, 791]]	1.0	5ljj	OTHER_TTK_HUMAN	CAMK	5.7e-54	189.2	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5MRBA	P33981	519	795	857.0	C5N:60901	Type1	Inactive	DFGin	3.9904	15.0552	ABAminus	-88.14, -37.43	-145.51, 169.37	-114.29, 5.64	296.03, 167.61	72.21, 9.85	out-out	out	11.2038	Saltbr-out	6.0746	HRD-in	-67.77, -54.4	68.39, 11.32	out-out-out	SNCooo	out-out	ActLoopNT-out	11.0039	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nooo	APE10-dihe-na	-119.93, 125.86	APE9-dihe-na	65.05, 26.68	APE8-dihe-in	-57.09, 145.6	APE8-rot-out	189.99	APE67-dihe-in	-63.9, -20.76	-103.43, 7.11	APE12-dist-none	999.0	APE11-dist-out	21.193	APE10-dist-out	18.5012	APE9-dist-out	10.5598	C604Y	None	None	XRAY	2.2	0.175	0.216	A	313.0	259.0	18	30	25	5	[[525, 791]]	1.0	5mrb	OTHER_TTK_HUMAN	CAMK	5.7e-54	189.2	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5EH0A	P33981	516	794	857.0	5NW:801	Type1	Inactive	DFGin	4.285	14.957	ABAminus	-70.51, -43.24	-138.73, 164.35	-108.25, 7.22	296.58, 162.45	73.13, 1.25	out-out	out	10.7486	Saltbr-out	5.9776	HRD-in	-63.67, -57.11	75.04, -3.07	out-out-out	SNCooo	out-out	ActLoopNT-out	11.5337	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 128.74	APE8-dihe-in	-112.66, 155.78	APE8-rot-out	188.67	APE67-dihe-in	-62.69, -27.07	-106.54, 4.68	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	11.8837	None	None	None	XRAY	2.18	0.198	0.216	A	279.0	258.0	21	30	20	10	[[525, 791]]	1.0	5eh0	OTHER_TTK_HUMAN	CAMK	5.4e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	6H3KA	P33981	519	794	857.0	FMW:60801	Type1	Inactive	DFGin	4.2889	15.0597	ABAminus	-78.15, -56.1	-128.46, 166.12	-108.06, 3.12	300.73, 163.62	73.15, 6.23	out-out	out	10.843	Saltbr-out	5.6002	HRD-in	-55.05, -54.84	64.62, 9.92	out-out-out	SNCooo	out-out	ActLoopNT-out	11.8452	ActLoopCT-out	nonTYR	APEdihe_aanoi	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, 144.7	APE8-rot-out	181.2	APE67-dihe-in	-63.91, -24.73	-102.23, 3.19	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.48	0.209	0.231	A	279.0	254.0	22	30	18	12	[[525, 791]]	1.0	6h3k	OTHER_TTK_HUMAN	CAMK	5.4e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4JS8A	P33981	515	793	857.0	1PF:801	Type1	Inactive	DFGin	4.2459	15.0178	ABAminus	-84.57, -49.34	-133.98, 167.4	-109.17, 14.51	305.07, 151.28	67.69, 15.63	in-out	in	9.9926	Saltbr-out	6.6989	HRD-in	-62.96, -52.34	70.46, -10.5	out-out-out	SNCooo	out-out	ActLoopNT-out	12.0357	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, 112.01	APE9-dihe-na	-104.69, -175.56	APE8-dihe-in	-119.7, 153.55	APE8-rot-none	999.0	APE67-dihe-in	-65.36, -29.34	-115.57, 0.38	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	20.1985	APE9-dist-out	12.1114	None	TPO675,TPO686	TPO675,TPO686	XRAY	1.94	0.232	0.253	A	281.0	261.0	18	30	22	8	[[525, 791]]	1.0	4js8	OTHER_TTK_HUMAN	CAMK	5.6e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4JT3A	P33981	515	794	857.0	1PH:805	Type1	Inactive	DFGin	3.8684	14.8151	ABAminus	-98.39, -37.1	-134.23, 157.73	-105.72, 6.6	314.7, 129.31	71.51, 16.26	out-out	out	10.738	Saltbr-out	7.6842	HRD-in	-58.42, -47.48	62.69, -17.16	out-out-out	SNCooo	out-out	ActLoopNT-out	11.5117	ActLoopCT-out	nonTYR	APEdihe_aaooi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, -122.0	APE8-dihe-out	49.94, -124.02	APE8-rot-out	48.54	APE67-dihe-in	-61.75, -25.83	-97.12, 5.24	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	12.6794	None	None	None	XRAY	2.2	0.239	0.251	A	281.0	254.0	26	30	17	13	[[525, 791]]	1.0	4jt3	OTHER_TTK_HUMAN	CAMK	5.6e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4O6LA	P33981	515	793	857.0	2QK:1001	Type1	Inactive	DFGin	4.4074	15.1513	ABAminus	-90.1, -59.73	-114.17, 174.24	-104.1, 2.53	293.21, 159.51	80.72, 3.9	out-out	out	10.0489	Saltbr-out	6.4053	HRD-in	-59.12, -54.03	77.12, -18.06	out-out-out	SNCooo	out-out	ActLoopNT-out	12.3634	ActLoopCT-out	nonTYR	APEdihe_aanoi	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, 142.49	APE8-rot-out	181.91	APE67-dihe-in	-58.9, -26.81	-100.7, 0.85	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	TPO675,TPO676,SEP677	TPO675,TPO676,SEP677	XRAY	2.38	0.211	0.25	A	281.0	260.0	19	30	22	8	[[525, 791]]	1.0	4o6l	OTHER_TTK_HUMAN	CAMK	5.6e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4O6LB	P33981	515	793	857.0	2QK:1001	Type1	Inactive	DFGin	4.2812	15.0712	ABAminus	-86.79, -57.52	-123.5, 173.75	-102.84, -0.16	292.99, 165.07	73.6, 3.12	out-out	out	10.2905	Saltbr-out	6.2048	HRD-in	-50.51, -55.85	77.18, -15.75	out-out-out	SNCooo	out-out	ActLoopNT-out	11.3245	ActLoopCT-out	nonTYR	APEdihe_aaooi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 139.99	APE8-dihe-out	-73.42, -65.35	APE8-rot-out	60.02	APE67-dihe-in	-53.59, -30.18	-99.07, -3.9	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	12.391	None	TPO675,TPO676,SEP677	TPO675,TPO676,SEP677	XRAY	2.38	0.211	0.25	B	281.0	256.0	23	30	19	11	[[525, 791]]	1.0	4o6l	OTHER_TTK_HUMAN	CAMK	5.6e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4ZEGA	P33981	516	795	857.0	052:809	Type1	Inactive	DFGin	3.84	13.665	ABAminus	-89.35, -39.59	-147.37, 179.43	-120.68, 6.65	313.22, 129.95	72.3, 17.48	in-in	in	9.387	Saltbr-in	2.9346	HRD-in	-62.37, -56.18	83.02, -11.88	in-out-out	SNCioo	out-out	ActLoopNT-out	12.0247	ActLoopCT-out	nonTYR	APEdihe_aanoi	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, -10.83	APE8-rot-out	193.46	APE67-dihe-in	-54.14, -26.3	-124.62, 9.96	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.33	0.212	0.263	A	281.0	260.0	20	30	19	11	[[525, 791]]	1.0	4zeg	OTHER_TTK_HUMAN	CAMK	5.6e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	7CILA	P33981	515	795	857.0	FZR:801	Type1	Inactive	DFGin	3.9331	14.2557	ABAminus	-117.55, -29.06	-108.82, 151.92	-103.82, 8.49	303.9, 127.51	74.56, 17.84	in-in	in	9.4382	Saltbr-in	3.3648	HRD-in	-65.5, -48.3	84.67, -24.88	in-out-out	SNCioo	out-out	ActLoopNT-out	12.9001	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, 92.45	APE9-dihe-na	-62.61, -177.02	APE8-dihe-in	-129.03, 162.3	APE8-rot-none	999.0	APE67-dihe-in	-61.04, -14.98	-137.19, -4.93	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	20.1466	APE9-dist-out	12.9573	None	TPO686	TPO686	XRAY	2.3	0.213	0.246	A	281.0	265.0	16	30	21	9	[[525, 791]]	1.0	7cil	OTHER_TTK_HUMAN	CAMK	5.6e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	7CHNA	P33981	515	795	857.0	FZL:60801	Type1	Inactive	DFGin	4.1927	13.8065	ABAminus	-108.25, -28.45	-114.71, 169.67	-123.6, 14.83	311.38, 132.14	76.06, -17.71	in-out	in	9.5097	Saltbr-out	3.8365	HRD-in	-65.71, -57.35	92.03, -36.01	out-out-out	SNCooo	out-out	ActLoopNT-out	12.7753	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, 106.35	APE9-dihe-na	-38.75, 152.63	APE8-dihe-in	-100.45, 171.07	APE8-rot-none	999.0	APE67-dihe-in	-64.61, -12.97	-144.48, -3.21	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	19.7825	APE9-dist-out	12.3733	None	TPO675,TPO676,SEP677,TPO686	TPO675,TPO676,SEP677,TPO686	XRAY	2.4	0.209	0.256	A	282.0	265.0	16	30	26	4	[[525, 791]]	1.0	7chn	OTHER_TTK_HUMAN	CAMK	5.6e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	7CHTA	P33981	515	794	857.0	FZO:801	Type1	Inactive	DFGin	4.4498	14.1666	ABAminus	-112.95, -55.33	-89.89, 146.93	-112.72, 5.43	293.25, 164.69	101.6, -45.7	in-in	in	9.5394	Saltbr-in	3.3318	HRD-in	-54.87, -60.57	87.7, -19.09	in-out-none	SNCion	out-none	ActLoopNT-out	12.8282	ActLoopCT-none	nonTYR	APEdihe_aanni	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, -128.46	APE8-rot-none	999.0	APE67-dihe-in	-60.22, -14.09	-125.33, 1.76	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	TPO675,TPO676,SEP677,TPO686	TPO675,TPO676,SEP677,TPO686	XRAY	2.4	0.214	0.259	A	282.0	261.0	19	30	23	7	[[525, 791]]	1.0	7cht	OTHER_TTK_HUMAN	CAMK	5.6e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	7CJAA	P33981	515	795	857.0	G0U:60801	Type1	Inactive	DFGin	4.565	14.3804	ABAminus	-123.14, -50.22	-110.86, 109.05	-73.21, 16.92	303.06, 178.86	54.4, 45.65	in-in	in	9.4206	Saltbr-in	3.1362	HRD-in	-56.29, -55.19	87.57, -24.84	in-out-out	SNCioo	out-out	ActLoopNT-out	12.6282	ActLoopCT-out	nonTYR	APEdihe_aaoni	APEdist_nnoo	APE10-dihe-na	999.0, -106.12	APE9-dihe-na	88.75, 151.9	APE8-dihe-out	-119.49, -174.64	APE8-rot-none	999.0	APE67-dihe-in	-62.96, -21.71	-126.19, -8.32	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	19.6901	APE9-dist-out	13.0613	None	TPO675,TPO676,SEP677,TPO686	TPO675,TPO676,SEP677,TPO686	XRAY	2.49	0.212	0.253	A	283.0	263.0	18	30	22	8	[[525, 791]]	1.0	7cja	OTHER_TTK_HUMAN	CAMK	5.7e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	7CLHA	P33981	516	795	857.0	G5C:801	Type1	Inactive	DFGin	4.3116	14.6343	ABAminus	-128.87, -39.46	-112.78, 121.46	-81.6, 17.57	300.39, 1.38	66.14, 9.26	out-out	out	10.9601	Saltbr-out	4.4183	HRD-in	-65.1, -39.58	41.54, 27.85	out-out-out	SNCooo	out-out	ActLoopNT-out	12.3383	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, 124.23	APE9-dihe-na	-106.52, -148.21	APE8-dihe-in	-158.76, 155.6	APE8-rot-none	999.0	APE67-dihe-in	-62.14, -23.44	-138.79, 13.28	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	20.4761	APE9-dist-out	12.4508	None	TPO675,TPO676,SEP677,TPO686	TPO675,TPO676,SEP677,TPO686	XRAY	2.9	0.21	0.272	A	283.0	260.0	20	30	21	9	[[525, 791]]	1.0	7clh	OTHER_TTK_HUMAN	CAMK	5.7e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4D2SA	P33981	513	793	857.0	DYK:1794	Type1	Inactive	DFGin	4.2732	14.7666	ABAminus	-95.21, -44.96	-135.94, 172.0	-115.3, 6.49	305.25, 149.5	77.48, -1.71	out-out	out	10.7098	Saltbr-out	6.6144	HRD-in	-50.94, -45.09	68.46, -25.84	out-none-out	SNCono	none-out	ActLoopNT-none	999.0	ActLoopCT-out	nonTYR	APEdihe_aanoi	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, 127.79	APE8-rot-out	187.01	APE67-dihe-in	-52.43, -42.93	-100.42, -1.9	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.5	0.181	0.221	A	284.0	249.0	32	30	13	17	[[525, 791]]	1.0	4d2s	OTHER_TTK_HUMAN	CAMK	5.8e-54	189.0	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	6TN9A	P33981	515	794	857.0	NN5:60901	Type1	Inactive	DFGin	4.4623	14.4733	ABAminus	-102.75, -43.17	-113.58, 151.32	-116.65, 21.41	306.29, 152.97	57.99, 34.15	in-out	in	9.9847	Saltbr-out	5.9616	HRD-in	-27.83, -60.59	74.73, -24.14	out-out-out	SNCooo	out-out	ActLoopNT-out	12.0589	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnoo	APE10-dihe-na	999.0, 137.59	APE9-dihe-na	-76.58, 147.78	APE8-dihe-in	-71.18, 119.63	APE8-rot-out	196.33	APE67-dihe-in	-109.27, 4.01	-95.26, 38.71	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	20.0955	APE9-dist-out	12.4585	None	None	None	XRAY	2.6	0.22	0.265	A	294.0	257.0	23	30	16	14	[[525, 791]]	1.0	6tn9	OTHER_TTK_HUMAN	CAMK	6.6e-54	188.9	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	6TNCA	P33981	516	794	857.0	O23:901	Type1	Inactive	DFGin	3.8222	13.2707	ABAminus	-102.01, -20.32	-149.44, 176.26	-124.03, 9.64	314.66, 123.73	67.72, 11.06	in-in	in	9.5574	Saltbr-in	2.629	HRD-in	-64.18, -55.18	74.7, 4.91	in-out-out	SNCioo	out-out	ActLoopNT-out	11.7796	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, -38.28	APE9-dihe-na	92.43, 140.71	APE8-dihe-in	-88.61, 139.32	APE8-rot-none	999.0	APE67-dihe-in	-66.01, -24.33	-119.33, 14.55	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	21.1573	APE9-dist-out	12.4568	None	TPO686	TPO686	XRAY	2.3	0.189	0.236	A	294.0	259.0	20	30	20	10	[[525, 791]]	1.0	6tnc	OTHER_TTK_HUMAN	CAMK	6.6e-54	188.9	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	6N6OA	P33981	515	794	857.0	KE7:801	Type1	Inactive	DFGin	4.2196	15.0738	ABAminus	-105.7, -27.81	-128.43, 140.87	-98.61, 4.99	296.05, 169.82	72.39, 7.89	out-out	out	11.0004	Saltbr-out	6.7761	HRD-in	-62.81, -50.74	78.47, -21.46	out-out-none	SNCoon	out-none	ActLoopNT-out	12.0654	ActLoopCT-none	nonTYR	APEdihe_aanni	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, 115.88	APE8-rot-none	999.0	APE67-dihe-in	-66.56, -23.16	-93.67, -1.52	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.6	0.202	0.244	A	285.0	254.0	26	30	14	16	[[525, 791]]	1.0	6n6o	OTHER_TTK_HUMAN	CAMK	5.9e-54	189.0	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	3GFWA	P33981	519	794	857.0	S22:60001	Type1	Inactive	DFGin	4.0966	15.4766	ABAminus	-102.94, -15.31	-151.43, 156.9	-123.98, 8.09	299.84, 155.88	79.83, 9.4	out-out	out	11.3341	Saltbr-out	6.8637	HRD-in	-62.59, -52.13	64.76, 15.17	out-none-out	SNCono	none-out	ActLoopNT-none	999.0	ActLoopCT-out	nonTYR	APEdihe_aaoni	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, -173.82	APE8-dihe-out	-84.76, -70.14	APE8-rot-none	999.0	APE67-dihe-in	-56.76, -41.42	-66.21, -14.77	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	12.9545	None	None	None	XRAY	2.74	0.206	0.239	A	313.0	249.0	27	30	14	16	[[525, 791]]	1.0	3gfw	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4BHZA	P33981	519	794	857.0	Z0B:61797	Type1	Inactive	DFGin	3.814	15.1497	ABAminus	-70.44, -40.37	-152.25, 172.63	-109.58, -2.5	303.76, 168.45	78.58, 3.35	out-out	out	11.1106	Saltbr-out	6.7851	HRD-in	-65.48, -51.8	72.15, -21.43	out-out-out	SNCooo	out-out	ActLoopNT-out	11.6571	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nooo	APE10-dihe-na	-146.03, 131.66	APE9-dihe-na	99.43, -38.47	APE8-dihe-in	-33.12, 126.88	APE8-rot-out	212.76	APE67-dihe-in	-59.36, -27.47	-101.37, 0.38	APE12-dist-none	999.0	APE11-dist-out	16.9031	APE10-dist-out	14.3888	APE9-dist-out	10.5608	None	None	None	XRAY	2.85	0.189	0.23	A	313.0	248.0	28	30	18	12	[[525, 791]]	1.0	4bhz	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4BI0A	P33981	519	794	857.0	Z0W:61797	Type1	Inactive	DFGin	3.8287	15.1412	ABAminus	-77.7, -43.35	-147.59, 168.95	-104.67, -7.65	305.3, 161.34	84.08, 0.49	out-out	out	11.2167	Saltbr-out	6.6201	HRD-in	-66.77, -48.18	66.87, -13.99	out-out-out	SNCooo	out-out	ActLoopNT-out	11.707	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nooo	APE10-dihe-na	-172.15, 129.89	APE9-dihe-na	90.95, -5.9	APE8-dihe-in	-61.15, 137.1	APE8-rot-out	197.64	APE67-dihe-in	-62.02, -25.36	-102.46, -0.21	APE12-dist-none	999.0	APE11-dist-out	17.6319	APE10-dist-out	14.5074	APE9-dist-out	10.2609	None	None	None	XRAY	2.84	0.186	0.224	A	313.0	251.0	25	30	18	12	[[525, 791]]	1.0	4bi0	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4BI1A	P33981	519	794	857.0	ZO6:61797	Type1	Inactive	DFGin	3.9522	15.1631	ABAminus	-88.37, -33.85	-141.98, 170.47	-111.95, -2.75	300.7, 163.09	85.15, 1.05	out-out	out	11.0133	Saltbr-out	6.7454	HRD-in	-63.61, -47.43	80.83, -10.06	out-out-out	SNCooo	out-out	ActLoopNT-out	11.7435	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nooo	APE10-dihe-na	-95.81, 104.37	APE9-dihe-na	60.87, 40.67	APE8-dihe-in	-72.34, 145.56	APE8-rot-out	202.94	APE67-dihe-in	-59.86, -24.34	-106.41, -1.69	APE12-dist-none	999.0	APE11-dist-out	16.4744	APE10-dist-out	16.2766	APE9-dist-out	9.9811	None	None	None	XRAY	2.7	0.19	0.228	A	313.0	249.0	27	30	17	13	[[525, 791]]	1.0	4bi1	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4BI2A	P33981	519	794	857.0	ZO8:61797	Type1	Inactive	DFGin	3.6197	15.1474	ABAminus	-76.55, -49.66	-141.71, 170.77	-111.27, 13.59	318.83, 139.2	57.0, 30.87	out-out	out	11.3366	Saltbr-out	7.1063	HRD-in	-54.6, -40.14	69.57, -18.49	out-out-out	SNCooo	out-out	ActLoopNT-out	11.7154	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nooo	APE10-dihe-na	-155.03, 149.01	APE9-dihe-na	97.44, -33.31	APE8-dihe-in	-41.38, 118.56	APE8-rot-out	207.3	APE67-dihe-in	-61.97, -21.49	-89.45, -2.47	APE12-dist-none	999.0	APE11-dist-out	17.1053	APE10-dist-out	13.3877	APE9-dist-out	10.3629	None	None	None	XRAY	3.11	0.195	0.226	A	313.0	250.0	26	30	17	13	[[525, 791]]	1.0	4bi2	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4C4EA	P33981	519	794	857.0	4T9:61796	Type1	Inactive	DFGin	4.0304	15.1877	ABAminus	-90.34, -24.49	-149.19, 168.21	-113.7, 5.3	302.17, 159.25	73.5, 10.67	out-out	out	11.1006	Saltbr-out	6.8613	HRD-in	-63.89, -49.54	74.97, -11.85	out-out-out	SNCooo	out-out	ActLoopNT-out	11.8306	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nooo	APE10-dihe-na	-179.93, 127.94	APE9-dihe-na	94.59, -22.08	APE8-dihe-in	-45.98, 144.24	APE8-rot-none	999.0	APE67-dihe-in	-66.59, -18.55	-116.67, 4.35	APE12-dist-none	999.0	APE11-dist-out	17.2125	APE10-dist-out	14.589	APE9-dist-out	10.4262	None	TPO686	TPO686	XRAY	2.6	0.188	0.212	A	313.0	254.0	22	30	21	9	[[525, 791]]	1.0	4c4e	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4C4FA	P33981	519	794	857.0	7CE:61799	Type1	Inactive	DFGin	4.1032	15.2155	ABAminus	-101.62, -18.54	-147.87, 165.66	-113.0, 7.85	297.15, 168.51	67.15, 10.57	out-out	out	11.1151	Saltbr-out	6.3853	HRD-in	-61.91, -51.34	67.18, 3.65	out-out-out	SNCooo	out-out	ActLoopNT-out	11.6937	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nooo	APE10-dihe-na	-53.1, 141.36	APE9-dihe-na	95.36, -36.89	APE8-dihe-in	-36.14, 134.58	APE8-rot-none	999.0	APE67-dihe-in	-62.14, -22.97	-109.48, -8.06	APE12-dist-none	999.0	APE11-dist-out	16.9493	APE10-dist-out	13.6166	APE9-dist-out	10.4933	None	TPO686	TPO686	XRAY	2.36	0.193	0.222	A	313.0	251.0	25	30	18	12	[[525, 791]]	1.0	4c4f	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4C4GA	P33981	519	794	857.0	7RO:61796	Type1	Inactive	DFGin	3.9507	14.9105	ABAminus	-95.92, -23.51	-152.6, 169.34	-115.91, 15.19	313.37, 131.38	68.79, 7.18	out-out	out	10.4725	Saltbr-out	6.4011	HRD-in	-66.58, -56.34	70.86, -10.66	out-none-out	SNCono	none-out	ActLoopNT-none	999.0	ActLoopCT-out	nonTYR	APEdihe_aaono	APEdist_nnoo	APE10-dihe-na	999.0, -23.29	APE9-dihe-na	75.51, 47.64	APE8-dihe-out	-83.97, -34.84	APE8-rot-none	999.0	APE67-dihe-out	-67.58, -18.15	68.34, -13.32	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	15.7424	APE9-dist-out	10.0984	None	TPO686	TPO686	XRAY	2.65	0.194	0.223	A	313.0	248.0	28	30	15	15	[[525, 791]]	1.0	4c4g	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4C4HA	P33981	519	794	857.0	7RO:61795	Type1	Inactive	DFGin	3.9512	14.7878	ABAminus	-80.93, -53.88	-130.38, 169.34	-111.71, 6.58	311.9, 132.59	84.63, -4.86	out-out	out	10.6984	Saltbr-out	6.3463	HRD-in	-63.34, -62.87	84.67, -29.96	out-none-out	SNCono	none-out	ActLoopNT-none	999.0	ActLoopCT-out	nonTYR	APEdihe_aanoi	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, 148.95	APE8-rot-out	194.44	APE67-dihe-in	-60.4, -21.07	-128.85, -4.66	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.8	0.199	0.241	A	313.0	245.0	31	30	13	17	[[525, 791]]	1.0	4c4h	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4C4IA	P33981	519	794	857.0	X20:61795	Type1	Inactive	DFGin	4.0896	14.9117	ABAminus	-85.8, -40.53	-139.92, 167.53	-117.17, 9.6	306.74, 149.34	84.49, -23.76	out-out	out	10.6367	Saltbr-out	5.823	HRD-in	-64.02, -48.25	79.16, -8.53	out-out-out	SNCooo	out-out	ActLoopNT-out	9.7954	ActLoopCT-out	nonTYR	APEdihe_aanoi	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, 148.09	APE8-rot-out	199.19	APE67-dihe-in	-59.18, -16.03	-127.61, 0.23	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.65	0.192	0.213	A	313.0	250.0	26	30	16	14	[[525, 791]]	1.0	4c4i	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4C4JA	P33981	519	794	857.0	X21:61795	Type1	Inactive	DFGin	4.4038	13.9195	ABAminus	-109.95, -30.18	-116.46, 149.35	-120.89, 12.34	310.2, 113.73	68.77, 1.44	in-in	in	9.3376	Saltbr-in	2.8087	HRD-in	-65.51, -59.05	77.98, -5.37	in-out-out	SNCioo	out-out	ActLoopNT-out	12.2944	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, 21.19	APE9-dihe-na	-150.7, 175.28	APE8-dihe-in	-114.81, 156.56	APE8-rot-none	999.0	APE67-dihe-in	-60.74, -34.36	-112.12, -16.33	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	17.8481	APE9-dist-out	12.2327	None	TPO686	TPO686	XRAY	2.5	0.194	0.21	A	313.0	259.0	17	30	22	8	[[525, 791]]	1.0	4c4j	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4CV8A	P33981	519	794	857.0	3D7:61795	Type1	Inactive	DFGin	4.1365	15.2721	ABAminus	-101.65, -40.07	-103.15, 134.35	-95.86, -0.86	282.15, 159.92	70.87, 15.07	out-none	out	10.3792	Saltbr-none	999.0	HRD-in	-64.98, -43.27	71.23, -61.83	none-out-out	SNCnoo	out-out	ActLoopNT-out	11.8569	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 73.12	APE8-dihe-in	-68.11, 137.84	APE8-rot-out	188.9	APE67-dihe-in	-71.84, -5.33	-100.06, 9.29	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	12.5295	None	None	None	XRAY	3.0	0.182	0.226	A	313.0	252.0	24	30	17	13	[[525, 791]]	1.0	4cv8	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4CV9A	P33981	519	794	857.0	W2K:61795	Type1	Inactive	DFGin	4.2474	15.0389	ABAminus	-101.91, -20.01	-131.88, 149.02	-113.92, 7.67	289.67, 174.21	75.29, -6.63	out-out	out	10.2073	Saltbr-out	6.3515	HRD-in	-64.0, -47.62	80.61, -7.87	out-out-out	SNCooo	out-out	ActLoopNT-out	11.6669	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, 146.4	APE9-dihe-na	-66.62, 130.4	APE8-dihe-in	-114.41, 114.43	APE8-rot-none	999.0	APE67-dihe-in	-66.76, -19.17	-78.46, 1.95	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	19.3938	APE9-dist-out	11.2853	None	TPO686	TPO686	XRAY	2.5	0.188	0.232	A	313.0	251.0	25	30	16	14	[[525, 791]]	1.0	4cv9	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	4CVAA	P33981	519	794	857.0	WBI:61795	Type1	Inactive	DFGin	4.1371	15.0836	ABAminus	-103.64, -29.1	-121.8, 152.79	-114.4, 8.52	290.87, 175.57	75.57, -11.77	out-out	out	10.5105	Saltbr-out	6.7222	HRD-in	-51.45, -55.15	67.0, 6.09	out-out-out	SNCooo	out-out	ActLoopNT-out	11.9303	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, 131.79	APE9-dihe-na	-118.82, 123.96	APE8-dihe-in	-82.49, 163.19	APE8-rot-none	999.0	APE67-dihe-in	-61.35, -24.47	-128.46, -2.58	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	20.162	APE9-dist-out	11.8818	None	TPO686	TPO686	XRAY	2.5	0.191	0.215	A	313.0	251.0	25	30	16	14	[[525, 791]]	1.0	4cva	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5AP0A	P33981	519	795	857.0	AU5:61795	Type1	Inactive	DFGin	3.9783	15.0028	ABAminus	-96.76, -22.08	-146.7, 164.38	-110.23, 9.55	298.65, 161.95	70.1, 0.89	out-out	out	11.0296	Saltbr-out	6.0499	HRD-in	-65.89, -53.49	72.58, -3.97	out-out-out	SNCooo	out-out	ActLoopNT-out	11.6332	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nooo	APE10-dihe-na	-63.25, 124.33	APE9-dihe-na	59.83, 23.25	APE8-dihe-in	-63.91, 141.71	APE8-rot-none	999.0	APE67-dihe-in	-66.96, -16.22	-115.17, -7.01	APE12-dist-none	999.0	APE11-dist-out	16.0418	APE10-dist-out	15.6429	APE9-dist-out	10.4402	None	TPO686	TPO686	XRAY	2.15	0.186	0.22	A	313.0	252.0	25	30	17	13	[[525, 791]]	1.0	5ap0	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5AP1A	P33981	519	795	857.0	O38:61796	Type1	Inactive	DFGin	4.1088	14.7281	ABAminus	-89.0, -45.75	-136.45, 170.67	-110.11, 13.99	300.68, 155.11	70.41, 10.72	in-out	in	9.6633	Saltbr-out	6.1057	HRD-in	-65.37, -51.62	69.07, -9.73	out-out-out	SNCooo	out-out	ActLoopNT-out	12.2118	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, 139.28	APE9-dihe-na	-84.72, -171.47	APE8-dihe-in	-119.66, 146.5	APE8-rot-none	999.0	APE67-dihe-in	-60.78, -20.45	-114.29, -8.4	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	19.8656	APE9-dist-out	12.4044	None	TPO675,TPO676,SEP677,TPO686	TPO675,TPO676,SEP677,TPO686	XRAY	2.05	0.195	0.211	A	313.0	268.0	9	30	28	2	[[525, 791]]	1.0	5ap1	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5AP2A	P33981	519	794	857.0	PWU:61795	Type1	Inactive	DFGin	3.691	14.021	ABAminus	-79.91, -47.41	-141.0, 175.42	-113.38, 7.32	320.57, 109.97	89.57, -32.6	in-in	in	9.7242	Saltbr-in	3.3984	HRD-in	-63.17, -34.41	72.38, -58.43	in-out-out	SNCioo	out-out	ActLoopNT-out	12.8241	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 169.79	APE8-dihe-in	-98.15, 169.16	APE8-rot-out	194.76	APE67-dihe-in	-65.72, -14.71	-128.84, -2.63	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	12.6585	None	None	None	XRAY	2.8	0.197	0.254	A	313.0	253.0	23	30	20	10	[[525, 791]]	1.0	5ap2	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5EHLA	P33981	519	796	857.0	0SQ:60901	Type1	Inactive	DFGin	4.2744	15.1576	ABAminus	-89.17, -26.97	-144.84, 160.15	-105.67, 2.47	304.42, 164.14	76.44, 12.25	out-none	out	10.8654	Saltbr-none	999.0	HRD-in	-63.29, -42.93	60.48, 0.47	none-out-out	SNCnoo	out-out	ActLoopNT-out	11.3913	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnoo	APE10-dihe-na	999.0, 165.8	APE9-dihe-na	-68.76, 160.5	APE8-dihe-in	-124.68, 151.59	APE8-rot-out	183.98	APE67-dihe-in	-53.53, -39.03	-99.14, 4.43	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	20.2412	APE9-dist-out	11.8872	None	None	None	XRAY	2.66	0.19	0.219	A	313.0	254.0	24	30	16	14	[[525, 791]]	1.0	5ehl	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5EHOA	P33981	519	794	857.0	5O1:60901	Type1	Inactive	DFGin	4.2634	15.0938	ABAminus	-83.34, -43.93	-140.36, 165.0	-106.3, 14.68	297.32, 167.25	72.3, 14.29	out-out	out	10.1676	Saltbr-out	6.5391	HRD-in	-62.9, -44.14	61.17, -2.98	out-out-out	SNCooo	out-out	ActLoopNT-out	12.1874	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnoo	APE10-dihe-na	999.0, 139.96	APE9-dihe-na	-95.06, 170.77	APE8-dihe-in	-134.87, 145.83	APE8-rot-out	174.69	APE67-dihe-in	-61.39, -34.62	-100.96, 10.08	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	19.4357	APE9-dist-out	11.772	None	None	None	XRAY	2.18	0.191	0.207	A	313.0	255.0	21	30	21	9	[[525, 791]]	1.0	5eho	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5EHYA	P33981	519	794	857.0	5O4:60908	Type1	Inactive	DFGin	4.042	15.1214	ABAminus	-87.29, -30.75	-144.51, 167.55	-109.84, 1.63	297.04, 168.45	76.09, -1.53	out-out	out	11.2157	Saltbr-out	6.3503	HRD-in	-65.33, -49.5	72.61, -2.8	out-out-out	SNCooo	out-out	ActLoopNT-out	11.8801	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnoo	APE10-dihe-na	999.0, 156.37	APE9-dihe-na	-85.3, 71.37	APE8-dihe-in	-68.61, 143.92	APE8-rot-out	179.84	APE67-dihe-in	-62.19, -35.71	-100.46, 6.76	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	18.1247	APE9-dist-out	9.939	None	None	None	XRAY	2.26	0.186	0.207	A	313.0	251.0	25	30	17	13	[[525, 791]]	1.0	5ehy	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5EI2A	P33981	516	794	857.0	5O7:901	Type1	Inactive	DFGin	3.9798	14.4755	ABAminus	-78.73, -52.63	-139.31, 160.64	-92.52, 2.93	318.22, 95.84	89.08, -7.34	out-out	out	10.4295	Saltbr-out	5.6581	HRD-in	-63.78, -50.07	70.22, -0.8	out-out-out	SNCooo	out-out	ActLoopNT-out	13.0351	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 160.32	APE8-dihe-in	-73.87, 160.97	APE8-rot-out	191.53	APE67-dihe-in	-64.29, -11.12	-129.83, -10.54	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	12.0301	None	None	None	XRAY	2.67	0.239	0.295	A	313.0	256.0	23	30	18	12	[[525, 791]]	1.0	5ei2	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5EI6A	P33981	519	794	857.0	5OQ:60901	Type1	Inactive	DFGin	3.9312	14.3472	ABAminus	-86.7, -33.46	-148.62, 167.92	-109.74, 12.61	310.8, 112.58	71.78, 5.46	in-out	in	9.9878	Saltbr-out	6.0297	HRD-in	-61.95, -54.54	69.88, -0.42	out-out-out	SNCooo	out-out	ActLoopNT-out	12.5318	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_oooo	APE10-dihe-na	-56.47, 134.25	APE9-dihe-na	-152.35, -175.71	APE8-dihe-in	-158.59, 132.95	APE8-rot-out	189.02	APE67-dihe-in	-61.48, -23.02	-109.15, 7.83	APE12-dist-out	18.7093	APE11-dist-out	20.4334	APE10-dist-out	18.8255	APE9-dist-out	11.9616	None	None	None	XRAY	2.01	0.198	0.221	A	313.0	261.0	15	30	25	5	[[525, 791]]	1.0	5ei6	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5EI8A	P33981	519	753	857.0	5OE:60901	Type1	Inactive	DFGin	4.2811	14.7695	ABAminus	-81.34, -45.63	-150.03, 174.99	-111.39, 21.62	317.11, 77.36	57.79, 25.49	out-out	out	10.3556	Saltbr-out	5.3615	HRD-in	-63.47, -50.78	71.71, -3.86	out-out-out	SNCooo	out-out	ActLoopNT-out	13.1071	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnoo	APE10-dihe-na	999.0, 107.39	APE9-dihe-na	-134.97, 110.16	APE8-dihe-in	-74.95, 151.91	APE8-rot-out	195.72	APE67-dihe-in	-64.93, -13.34	-115.39, 3.38	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	17.0382	APE9-dist-out	11.8053	None	None	None	XRAY	2.17	0.216	0.244	A	313.0	216.0	19	30	21	9	[[525, 791]]	1.0	5ei8	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5N87A	P33981	519	794	857.0	N66:60901	Type1	Inactive	DFGin	4.1741	15.0993	ABAminus	-88.48, -35.42	-150.02, 176.97	-116.22, 4.15	297.47, 158.19	69.2, 16.91	out-out	out	11.1121	Saltbr-out	6.4627	HRD-in	-74.45, -55.5	72.51, 8.91	out-out-out	SNCooo	out-out	ActLoopNT-out	11.4588	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nooo	APE10-dihe-na	-86.47, 133.33	APE9-dihe-na	70.41, 9.01	APE8-dihe-in	-52.47, 143.66	APE8-rot-none	999.0	APE67-dihe-in	-68.74, -15.33	-108.1, -7.79	APE12-dist-none	999.0	APE11-dist-out	18.0335	APE10-dist-out	15.2021	APE9-dist-out	9.8451	None	TPO686	TPO686	XRAY	2.29	0.2	0.238	A	313.0	253.0	23	30	18	12	[[525, 791]]	1.0	5n87	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5AP6A	P33981	519	794	857.0	PWU:61795	Type1	Inactive	DFGin	4.0071	14.3006	ABAminus	-114.86, -13.47	-145.86, 158.61	-108.81, 9.51	308.42, 109.78	72.17, 20.89	in-in	in	9.9065	Saltbr-in	2.9635	HRD-in	-61.13, -55.8	72.48, -11.9	in-out-out	SNCioo	out-out	ActLoopNT-out	12.9974	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_oooo	APE10-dihe-na	-48.78, 124.97	APE9-dihe-na	-141.21, -168.37	APE8-dihe-in	-169.63, 134.85	APE8-rot-out	190.42	APE67-dihe-in	-54.56, -26.33	-104.78, -10.65	APE12-dist-out	18.0487	APE11-dist-out	19.9004	APE10-dist-out	18.3065	APE9-dist-out	11.7896	C604W	None	None	XRAY	2.1	0.183	0.209	A	313.0	259.0	17	30	24	6	[[525, 791]]	1.0	5ap6	OTHER_TTK_HUMAN	CAMK	2.5e-53	187.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5AP7A	P33981	519	794	857.0	SVE:61795	Type1	Inactive	DFGin	4.0075	15.0106	ABAminus	-75.4, -47.55	-134.63, 175.4	-113.35, 2.93	298.14, 169.12	68.03, 11.08	out-out	out	11.2161	Saltbr-out	6.2883	HRD-in	-53.42, -53.82	66.3, 10.85	out-out-out	SNCooo	out-out	ActLoopNT-out	11.4759	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnoo	APE10-dihe-na	999.0, -94.63	APE9-dihe-na	-108.3, 120.24	APE8-dihe-in	-73.36, 151.59	APE8-rot-out	193.39	APE67-dihe-in	-46.84, -28.38	-104.91, -10.44	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	17.4934	APE9-dist-out	10.1157	C604W	None	None	XRAY	2.45	0.188	0.234	A	313.0	253.0	23	30	20	10	[[525, 791]]	1.0	5ap7	OTHER_TTK_HUMAN	CAMK	2.5e-53	187.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5O91A	P33981	519	796	857.0	C5N:60901	Type1	Inactive	DFGin	3.802	15.016	ABAminus	-78.15, -40.0	-151.19, 165.46	-106.99, 8.04	304.83, 159.67	51.06, 36.71	out-out	out	11.1062	Saltbr-out	6.4839	HRD-in	-71.98, -51.24	56.1, 25.02	out-out-out	SNCooo	out-out	ActLoopNT-out	11.3197	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nooo	APE10-dihe-na	-75.68, 72.2	APE9-dihe-na	66.53, 36.69	APE8-dihe-in	-74.19, 134.73	APE8-rot-out	176.75	APE67-dihe-in	-60.61, -35.71	-97.24, 8.51	APE12-dist-none	999.0	APE11-dist-out	17.7543	APE10-dist-out	18.9871	APE9-dist-out	10.2058	C604W	None	None	XRAY	3.2	0.214	0.254	A	313.0	261.0	17	30	24	6	[[525, 791]]	1.0	5o91	OTHER_TTK_HUMAN	CAMK	2.5e-53	187.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	6B4WA	P33981	515	793	857.0	CQ7:801	Type1	Inactive	DFGin	4.7938	13.168	ABAminus	-124.9, -1.56	-141.04, 152.98	-122.68, 8.74	304.31, 73.0	58.44, 34.07	in-none	in	9.9845	Saltbr-none	999.0	HRD-in	-75.92, -62.4	70.1, 24.42	none-out-out	SNCnoo	out-out	ActLoopNT-out	12.6411	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnoo	APE10-dihe-na	999.0, 142.31	APE9-dihe-na	-91.61, 164.96	APE8-dihe-in	-76.84, 169.09	APE8-rot-out	57.53	APE67-dihe-in	-71.32, -26.48	-122.98, 9.12	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	20.419	APE9-dist-out	13.2234	None	None	None	XRAY	2.9	0.194	0.253	A	303.0	259.0	20	30	21	9	[[525, 791]]	1.0	6b4w	OTHER_TTK_HUMAN	CAMK	7.4e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	2X9EA	P33981	515	795	857.0	SVE:1796	Type1	Inactive	DFGin	3.5234	14.6918	ABAminus	-97.78, -42.88	-144.87, 174.21	-107.75, 2.72	297.55, 168.15	71.6, 31.63	out-out	out	11.0537	Saltbr-out	5.6713	HRD-in	-68.71, -48.71	69.68, -10.51	out-out-out	SNCooo	out-out	ActLoopNT-out	11.5166	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 32.06	APE8-dihe-in	-85.14, 170.49	APE8-rot-out	171.47	APE67-dihe-in	-39.15, -60.16	-95.37, -10.13	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	11.7324	None	None	None	XRAY	3.1	0.215	0.306	A	317.0	254.0	27	30	15	15	[[525, 791]]	1.0	2x9e	OTHER_TTK_HUMAN	CAMK	8.7e-54	188.5	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	3VQUA	P33981	516	795	857.0	O22:909	Type1	Inactive	DFGin	3.9763	14.9659	ABAminus	-81.75, -53.65	-129.74, 172.69	-111.26, 9.8	306.0, 159.19	69.59, 10.96	out-out	out	10.3421	Saltbr-out	6.0544	HRD-out	-61.39, 148.14	-116.24, 0.39	out-out-out	SNCooo	out-out	ActLoopNT-out	11.8806	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 166.62	APE8-dihe-in	-143.47, 148.23	APE8-rot-out	189.58	APE67-dihe-in	-60.98, -38.83	-96.2, 17.0	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	12.1343	None	None	None	XRAY	2.4	0.251	0.284	A	320.0	258.0	22	30	20	10	[[525, 791]]	1.0	3vqu	OTHER_TTK_HUMAN	CAMK	9e-54	188.5	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	3WYXA	P33981	516	795	857.0	O38:902	Type1	Inactive	DFGin	3.839	14.4009	ABAminus	-92.88, -48.98	-138.38, 177.59	-116.03, 10.0	308.72, 129.43	75.11, 2.89	in-out	in	9.7357	Saltbr-out	5.9966	HRD-out	-64.04, 113.3	-83.23, 11.65	out-out-out	SNCooo	out-out	ActLoopNT-out	12.0726	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 88.77	APE8-dihe-in	-123.04, 145.7	APE8-rot-out	168.34	APE67-dihe-in	-60.5, -36.82	-102.78, 9.66	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	11.6667	None	None	None	XRAY	2.9	0.234	0.273	A	321.0	258.0	22	30	19	11	[[525, 791]]	1.0	3wyx	OTHER_TTK_HUMAN	CAMK	9.1e-54	188.4	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	3WYYA	P33981	516	795	857.0	O17:901	Type1	Inactive	DFGin	3.9824	14.4179	ABAminus	-85.96, -42.58	-150.53, 171.45	-108.18, 9.47	313.94, 99.77	63.89, 38.79	in-out	in	9.4486	Saltbr-out	5.5718	HRD-out	-71.41, 84.78	-72.82, 23.64	out-out-out	SNCooo	out-out	ActLoopNT-out	12.3411	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 114.86	APE8-dihe-in	-127.04, 157.36	APE8-rot-out	170.56	APE67-dihe-in	-53.64, -55.08	-100.41, 9.5	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	11.8347	None	None	None	XRAY	3.05	0.229	0.281	A	321.0	258.0	22	30	19	11	[[525, 791]]	1.0	3wyy	OTHER_TTK_HUMAN	CAMK	9.1e-54	188.4	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5N7VA	P33981	519	794	857.0	8PT:60901	Type1	Inactive	DFGin	3.9799	14.7625	ABAminus	-96.64, -47.45	-131.22, 170.52	-125.08, -20.32	308.53, 165.4	127.69, 98.89	out-out	out	11.1165	Saltbr-out	6.0234	HRD-in	-71.01, -50.2	68.87, 0.08	out-out-out	SNCooo	out-out	ActLoopNT-out	11.9896	ActLoopCT-out	nonTYR	APEdihe_aaono	APEdist_oooo	APE10-dihe-na	-107.54, -172.28	APE9-dihe-na	75.07, -51.21	APE8-dihe-out	34.13, -74.99	APE8-rot-none	999.0	APE67-dihe-out	-102.08, -11.37	79.21, 21.03	APE12-dist-out	19.2341	APE11-dist-out	17.281	APE10-dist-out	12.4427	APE9-dist-out	10.0448	None	TPO686	TPO686	XRAY	2.52	0.198	0.278	A	313.0	258.0	18	30	23	7	[[525, 791]]	1.0	5n7v	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5N84A	P33981	519	794	857.0	8Q5:60901	Type1	Inactive	DFGin	4.1659	15.4795	ABAminus	-104.85, -26.96	-154.67, 171.21	-114.47, 1.71	301.25, 166.2	82.91, 8.5	out-out	out	11.0769	Saltbr-out	6.3714	HRD-in	-78.13, -54.11	78.05, -3.05	out-out-out	SNCooo	out-out	ActLoopNT-out	11.715	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nooo	APE10-dihe-na	-130.46, 173.28	APE9-dihe-na	98.49, -39.6	APE8-dihe-in	-54.14, 151.84	APE8-rot-out	188.71	APE67-dihe-in	-57.09, -20.86	-123.2, -0.76	APE12-dist-none	999.0	APE11-dist-out	18.8057	APE10-dist-out	13.9014	APE9-dist-out	10.9684	None	None	None	XRAY	2.3	0.207	0.261	A	313.0	253.0	23	30	18	12	[[525, 791]]	1.0	5n84	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5N93A	P33981	519	794	857.0	8QE:60901	Type1	Inactive	DFGin	4.0192	15.1702	ABAminus	-92.51, -36.83	-150.25, 172.26	-115.14, 5.53	287.99, 174.16	76.77, 9.46	out-out	out	10.4196	Saltbr-out	6.3502	HRD-in	-65.77, -53.03	64.47, 9.27	out-out-out	SNCooo	out-out	ActLoopNT-out	11.3803	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, 137.01	APE9-dihe-na	-83.24, -158.05	APE8-dihe-in	-135.16, 151.14	APE8-rot-none	999.0	APE67-dihe-in	-70.41, -41.42	-123.42, 2.99	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	20.7717	APE9-dist-out	12.5572	None	TPO686	TPO686	XRAY	2.1	0.218	0.268	A	313.0	257.0	19	30	21	9	[[525, 791]]	1.0	5n93	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5NA0A	P33981	519	794	857.0	8QZ:60901	Type1	Inactive	DFGin	3.9061	14.9376	ABAminus	-90.39, -46.53	-134.15, 168.53	-113.06, 21.64	311.74, 142.6	50.45, 23.25	out-out	out	11.2604	Saltbr-out	7.0665	HRD-in	-75.64, -41.45	54.95, 31.21	out-out-out	SNCooo	out-out	ActLoopNT-out	11.3448	ActLoopCT-out	nonTYR	APEdihe_aaoni	APEdist_nnoo	APE10-dihe-na	999.0, 18.56	APE9-dihe-na	98.71, -54.8	APE8-dihe-out	17.03, 101.78	APE8-rot-none	999.0	APE67-dihe-in	-55.08, -25.7	-88.73, -14.04	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	17.278	APE9-dist-out	11.1515	None	TPO686	TPO686	XRAY	2.9	0.213	0.271	A	313.0	251.0	25	30	18	12	[[525, 791]]	1.0	5na0	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	3HMOA	P33981	514	794	857.0	STU:1	Type1	Inactive	DFGin	4.0338	15.2785	ABAminus	-96.9, -14.35	-154.28, 164.59	-116.14, 11.51	302.21, 156.99	70.91, 11.96	out-out	out	11.1476	Saltbr-out	6.638	HRD-in	-61.3, -53.03	75.35, 1.42	out-out-out	SNCooo	out-out	ActLoopNT-out	11.6803	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnoo	APE10-dihe-na	999.0, -169.39	APE9-dihe-na	94.05, 108.89	APE8-dihe-in	-96.62, 156.5	APE8-rot-out	54.19	APE67-dihe-in	-64.02, -25.79	-101.71, 14.64	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	19.1227	APE9-dist-out	11.5633	None	None	None	XRAY	2.4	0.217	0.261	A	342.0	257.0	24	30	18	12	[[525, 791]]	1.0	3hmo	OTHER_TTK_HUMAN	CAMK	1.1e-53	188.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	3HMPA	P33981	516	794	857.0	CX4:1	Type1	Inactive	DFGin	3.9572	15.1018	ABAminus	-86.78, -27.71	-156.64, 169.65	-114.18, 6.72	299.15, 162.64	67.41, 15.29	out-out	out	10.9081	Saltbr-out	5.6134	HRD-in	-69.93, -47.36	72.83, -1.07	out-out-out	SNCooo	out-out	ActLoopNT-out	11.521	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_oooo	APE10-dihe-na	-151.04, 159.23	APE9-dihe-na	115.47, 58.42	APE8-dihe-in	-54.12, 148.09	APE8-rot-out	185.33	APE67-dihe-in	-65.69, -24.89	-99.64, 11.65	APE12-dist-out	22.4555	APE11-dist-out	24.0625	APE10-dist-out	19.1836	APE9-dist-out	11.3824	None	None	None	XRAY	2.3	0.212	0.248	A	342.0	258.0	21	30	20	10	[[525, 791]]	1.0	3hmp	OTHER_TTK_HUMAN	CAMK	1.1e-53	188.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5AP3A	P33981	519	794	857.0	AU5:61799	Type1	Inactive	DFGin	3.7649	14.9222	ABAminus	-71.81, -53.86	-135.34, 169.43	-108.89, 4.49	312.31, 146.57	78.37, 4.18	out-out	out	10.8926	Saltbr-out	6.3905	HRD-in	-63.22, -46.84	80.03, -8.42	out-out-out	SNCooo	out-out	ActLoopNT-out	11.6168	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_iooo	APE10-dihe-na	-73.41, 128.83	APE9-dihe-na	68.53, 48.03	APE8-dihe-in	-104.01, 128.39	APE8-rot-none	999.0	APE67-dihe-in	-65.18, -22.8	-106.77, -2.15	APE12-dist-in	13.9565	APE11-dist-out	16.0915	APE10-dist-out	15.0093	APE9-dist-out	10.9961	S611G	TPO686	TPO686	XRAY	2.7	0.192	0.236	A	313.0	251.0	25	30	18	12	[[525, 791]]	1.0	5ap3	OTHER_TTK_HUMAN	CAMK	2.2e-53	187.3	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5AP4A	P33981	519	794	857.0	O38:61795	Type1	Inactive	DFGin	3.8933	14.6499	ABAminus	-77.41, -43.92	-141.98, 172.86	-114.54, 10.04	314.02, 147.43	47.66, 52.13	out-out	out	10.6444	Saltbr-out	5.0251	HRD-in	-63.63, -47.01	77.61, -5.77	out-out-out	SNCooo	out-out	ActLoopNT-out	11.4701	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nooo	APE10-dihe-na	-72.43, 107.58	APE9-dihe-na	57.19, 49.68	APE8-dihe-in	-65.83, 162.62	APE8-rot-none	999.0	APE67-dihe-in	-58.82, -25.47	-129.9, -17.39	APE12-dist-none	999.0	APE11-dist-out	16.4862	APE10-dist-out	16.147	APE9-dist-out	10.0398	S611G	TPO686	TPO686	XRAY	2.85	0.198	0.226	A	313.0	254.0	22	30	21	9	[[525, 791]]	1.0	5ap4	OTHER_TTK_HUMAN	CAMK	2.2e-53	187.3	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	2ZMDA	P33981	516	795	857.0	537:900	Type1	Inactive	DFGin	3.9529	15.1186	ABAminus	-86.61, -39.79	-132.74, 164.92	-108.9, 8.43	306.24, 151.22	69.07, 16.45	out-out	out	11.2826	Saltbr-out	6.7508	HRD-in	-68.0, -56.19	74.76, 7.11	out-out-out	SNCooo	out-out	ActLoopNT-out	10.4306	ActLoopCT-out	nonTYR	APEdihe_aaoni	APEdist_oooo	APE10-dihe-na	-150.77, 128.69	APE9-dihe-na	166.18, -134.04	APE8-dihe-out	62.78, 28.8	APE8-rot-none	999.0	APE67-dihe-in	-55.23, -33.98	-72.52, -20.32	APE12-dist-out	22.1515	APE11-dist-out	23.3484	APE10-dist-out	19.346	APE9-dist-out	12.2621	T686A	None	None	XRAY	2.88	0.223	0.261	A	390.0	259.0	21	30	21	9	[[525, 791]]	1.0	2zmd	OTHER_TTK_HUMAN	CAMK	9e-53	185.2	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	7LQDA	P33981	519	795	857.0	YB4:60901,TOE:60907	Type1,Allosteric	Inactive	DFGin	3.9246	14.3979	ABAminus	-86.7, -42.44	-142.37, 165.69	-105.81, -5.45	307.04, 124.04	74.94, 14.22	out-out	out	10.9537	Saltbr-out	5.9634	HRD-in	-63.64, -55.17	68.93, 10.11	out-out-out	SNCooo	out-out	ActLoopNT-out	10.1553	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_oooo	APE10-dihe-na	-132.63, 166.12	APE9-dihe-na	89.33, 75.78	APE8-dihe-in	-67.85, 152.21	APE8-rot-out	180.89	APE67-dihe-in	-62.72, -28.33	-111.8, 18.01	APE12-dist-out	23.1149	APE11-dist-out	24.2594	APE10-dist-out	18.9066	APE9-dist-out	11.3616	None	None	None	XRAY	1.95	0.2	0.246	A	313.0	265.0	12	30	29	1	[[525, 791]]	1.0	7lqd	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5AP5A	P33981	519	794	857.0	7RO:61795,1KA:61796	Type1,Type1	Inactive	DFGin	3.9362	14.9301	ABAminus	-78.19, -51.66	-127.65, 173.7	-118.82, 17.68	309.34, 138.77	57.34, 35.63	out-out	out	11.1518	Saltbr-out	5.6498	HRD-in	-63.52, -47.29	78.68, -5.43	out-none-out	SNCono	none-out	ActLoopNT-none	999.0	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 112.65	APE8-dihe-in	-71.0, 149.52	APE8-rot-out	187.62	APE67-dihe-in	-58.84, -28.01	-101.03, -8.19	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	10.7748	S611G	None	None	XRAY	2.8	0.205	0.246	A	313.0	248.0	28	30	14	16	[[525, 791]]	1.0	5ap5	OTHER_TTK_HUMAN	CAMK	2.2e-53	187.3	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	6TNDA	P33981	516	793	857.0	8RH:901	Type1.5_Back	Inactive	DFGin	3.6505	14.0375	ABAminus	-96.05, -33.83	-151.93, -175.24	-130.65, -1.1	295.33, 131.29	74.45, 12.68	in-in	in	9.5907	Saltbr-in	2.7252	HRD-in	-64.35, -53.45	78.33, -0.67	in-out-out	SNCioo	out-out	ActLoopNT-out	11.0929	ActLoopCT-out	nonTYR	APEdihe_aanoi	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, 162.09	APE8-rot-out	36.86	APE67-dihe-in	-70.08, -16.5	-127.52, 10.48	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.58	0.19	0.249	A	294.0	254.0	24	30	18	12	[[525, 791]]	1.0	6tnd	OTHER_TTK_HUMAN	CAMK	6.6e-54	188.9	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	3W1FA	P33981	516	795	857.0	1O5:901	Type1.5_Back	Inactive	DFGin	3.9519	14.4776	ABAminus	-90.62, -43.9	-139.59, 171.72	-118.91, 5.4	303.76, 137.67	67.79, 8.35	in-in	in	9.9038	Saltbr-in	3.2654	HRD-out	-68.15, 103.17	-73.45, -33.92	in-out-out	SNCioo	out-out	ActLoopNT-out	11.8835	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 117.05	APE8-dihe-in	-111.17, 166.66	APE8-rot-out	156.69	APE67-dihe-in	-56.81, -19.1	-120.87, 15.73	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	12.4089	None	None	None	XRAY	2.7	0.237	0.277	A	321.0	259.0	21	30	20	10	[[525, 791]]	1.0	3w1f	OTHER_TTK_HUMAN	CAMK	9.1e-54	188.4	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	3WZJA	P33981	516	794	857.0	O43:901	Type1.5_Back	Inactive	DFGin	3.7309	13.6505	ABAminus	-113.7, -33.36	-129.61, 174.06	-121.04, 7.96	308.49, 98.92	65.98, 3.68	in-in	in	9.5066	Saltbr-in	2.9723	HRD-in	-54.5, -49.24	80.42, -18.04	in-out-out	SNCioo	out-out	ActLoopNT-out	11.9175	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 38.01	APE8-dihe-in	-53.44, 162.3	APE8-rot-out	173.78	APE67-dihe-in	-44.25, -39.42	-139.56, 6.8	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	13.1111	None	None	None	XRAY	2.75	0.227	0.282	A	321.0	257.0	22	30	20	10	[[525, 791]]	1.0	3wzj	OTHER_TTK_HUMAN	CAMK	9.1e-54	188.4	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	3WZKA	P33981	516	794	857.0	O23:901	Type1.5_Back	Inactive	DFGin	3.9001	14.1238	ABAminus	-105.12, -8.93	-163.2, -176.41	-130.47, 5.31	306.84, 127.56	66.87, 25.4	in-in	in	9.6952	Saltbr-in	3.075	HRD-in	-65.77, -53.52	80.52, -6.31	in-out-out	SNCioo	out-out	ActLoopNT-out	11.9522	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, -152.25	APE8-dihe-in	-163.56, 150.82	APE8-rot-out	169.66	APE67-dihe-in	-62.44, -15.14	-116.23, 12.9	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	12.5051	None	None	None	XRAY	2.3	0.224	0.28	A	321.0	258.0	21	30	20	10	[[525, 791]]	1.0	3wzk	OTHER_TTK_HUMAN	CAMK	9.1e-54	188.4	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5NADA	P33981	519	794	857.0	8RH:60901	Type1.5_Back	Inactive	DFGin	3.6777	13.3894	ABAminus	-99.04, -34.18	-143.29, 171.26	-117.88, -6.39	312.7, 119.82	89.46, 5.32	in-in	in	9.5271	Saltbr-in	3.2076	HRD-in	-67.44, -48.54	53.7, 23.12	in-out-none	SNCion	out-none	ActLoopNT-out	11.5082	ActLoopCT-none	nonTYR	APEdihe_aanni	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, 112.82	APE8-rot-none	999.0	APE67-dihe-in	-61.69, -43.53	-106.91, 27.6	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	TPO686	TPO686	XRAY	2.8	0.21	0.29	A	313.0	254.0	22	30	19	11	[[525, 791]]	1.0	5nad	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	6TNBA	P33981	517	794	857.0	8QW:901	Type1.5_Front	Inactive	DFGin	3.8524	15.0944	ABAminus	-120.69, -13.19	-153.82, 168.98	-122.43, 7.93	296.97, 146.25	65.5, 17.91	out-out	out	11.0111	Saltbr-out	8.542	HRD-in	-60.06, -45.03	76.67, -3.67	out-out-out	SNCooo	out-out	ActLoopNT-out	12.1136	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 47.02	APE8-dihe-in	-74.89, 162.5	APE8-rot-none	999.0	APE67-dihe-in	-76.36, -29.64	-145.32, 10.05	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	13.1137	None	TPO686	TPO686	XRAY	2.65	0.215	0.262	A	294.0	252.0	26	30	15	15	[[525, 791]]	1.0	6tnb	OTHER_TTK_HUMAN	CAMK	6.6e-54	188.9	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	5N9SA	P33981	519	794	857.0	8QW:60901	Type1.5_Front	Inactive	DFGin	3.8664	14.7964	ABAminus	-103.91, -21.18	-148.36, 167.12	-113.73, -1.29	297.53, 126.79	78.88, 15.58	out-out	out	10.9598	Saltbr-out	9.124	HRD-in	-76.88, -53.0	67.73, 3.84	out-out-out	SNCooo	out-out	ActLoopNT-out	11.8167	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_oooo	APE10-dihe-na	176.56, 127.56	APE9-dihe-na	70.2, 2.51	APE8-dihe-in	-61.92, 151.57	APE8-rot-none	999.0	APE67-dihe-in	-61.07, -20.0	-114.51, -10.18	APE12-dist-out	19.5555	APE11-dist-out	17.1912	APE10-dist-out	14.162	APE9-dist-out	10.05	None	TPO686	TPO686	XRAY	2.3	0.194	0.245	A	313.0	257.0	19	30	23	7	[[525, 791]]	1.0	5n9s	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	AF-P33981-K1A	P33981	517	799	857.0	No_ligand	No_ligand	Inactive	DFGin	6.1818	14.6135	BLAminus	-126.46, 171.49	63.49, 76.21	-87.18, 16.05	291.59, 77.39	-58.32, -23.29	in-in	in	8.948	Saltbr-in	2.7779	HRD-in	-72.7, -40.65	66.56, -4.75	in-in-out	SNCiio	in-out	ActLoopNT-in	2.8991	ActLoopCT-out	nonTYR	APEdihe_aaiii	APEdist_iooi	APE10-dihe-na	-105.04, 133.54	APE9-dihe-na	-62.56, -157.84	APE8-dihe-in	-72.75, 119.13	APE8-rot-in	304.88	APE67-dihe-in	-66.58, -15.24	-44.46, -41.66	APE12-dist-in	10.7221	APE11-dist-out	6.3347	APE10-dist-out	9.705	APE9-dist-in	4.0446	None	None	None	AF2	-1.0	1.0	1.0	A	283.0	283.0	0	30	30	0	[[525, 791]]	1.0	AF-P33981-K1	OTHER_TTK_HUMAN	CAMK	5.7e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	3H9FA	P33981	519	794	857.0	92M:60809	Type1	Inactive	DFGin	4.8308	14.3787	BLAplus	-140.16, 165.23	51.54, 40.51	-99.09, 3.36	73.8, 81.33	-82.43, -174.41	in-none	in	9.9762	Saltbr-none	999.0	HRD-in	-53.0, -59.1	80.34, -10.85	none-out-out	SNCnoo	out-out	ActLoopNT-out	12.1437	ActLoopCT-out	nonTYR	APEdihe_aaoni	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 176.13	APE8-dihe-out	-96.95, -14.8	APE8-rot-none	999.0	APE67-dihe-in	-58.74, -15.24	-121.28, -11.7	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	13.615	None	TPO675,TPO676,SEP677	TPO675,TPO676,SEP677	XRAY	2.6	0.21	0.253	A	313.0	259.0	17	30	23	7	[[525, 791]]	1.0	3h9f	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	7CHMA	P33981	516	794	857.0	FZF:801	Type1	Inactive	DFGin	4.4135	14.6083	None	-111.88, -71.82	-63.89, 158.67	-119.5, 9.1	283.45, 179.72	82.92, -15.75	in-in	in	9.5598	Saltbr-in	3.396	HRD-in	-57.59, -51.23	60.31, 6.24	in-out-out	SNCioo	out-out	ActLoopNT-out	12.2637	ActLoopCT-out	nonTYR	APEdihe_aaoni	APEdist_nnoo	APE10-dihe-na	999.0, -62.47	APE9-dihe-na	66.11, 172.68	APE8-dihe-out	-121.28, -175.85	APE8-rot-none	999.0	APE67-dihe-in	-54.56, -33.62	-132.81, 0.36	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	19.8631	APE9-dist-out	12.904	None	TPO675,TPO686	TPO675,TPO686	XRAY	2.65	0.212	0.253	A	281.0	260.0	19	30	22	8	[[525, 791]]	1.0	7chm	OTHER_TTK_HUMAN	CAMK	5.6e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK

OTHER_TTK (Dual specificity protein kinase TTK)

Total number of chains: 78

Active chains: 1

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	ABAminus	74	94.9%	5AP1A
DFGin	BLAminus	2	2.6%	AF-P33981-K3A
DFGin	BLAplus	1	1.3%	3H9FA
DFGin	None	1	1.3%	7CHMA

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Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Species	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
TTK	TTK_HUMAN	AF-P33981-K3A	P33981	517	799	857.0	No_ligand	No_ligand	Active	DFGin	6.3009	15.0197	BLAminus	-134.12, 174.57	65.6, 59.77	-77.34, 9.88	287.47, 86.26	-59.03, -34.57	in-in	in	8.3972	Saltbr-in	2.6594	HRD-in	-73.18, -39.18	69.58, 0.64	in-in-in	SNCiii	in-in	ActLoopNT-in	2.8261	ActLoopCT-in	nonTYR	APEdihe_aaiii	APEdist_iiii	APE10-dihe-na	-135.89, 143.68	APE9-dihe-na	107.15, 164.37	APE8-dihe-in	-93.15, 118.3	APE8-rot-in	301.9	APE67-dihe-in	-66.11, -12.59	-45.21, -41.73	APE12-dist-in	9.3194	APE11-dist-in	11.1231	APE10-dist-in	5.4736	APE9-dist-in	3.5477	None	None	None	AF2	-1.0	1.0	1.0	A	283.0	283.0	0	30	30	0	[[525, 791]]	1.0	AF-P33981-K3	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.7e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	3HMNA	P33981	516	794	857.0	ATP:1	ATPlike	Inactive	DFGin	3.9993	14.9908	ABAminus	-98.05, -9.81	-153.31, 160.67	-110.5, 6.35	307.22, 150.55	69.66, 19.48	out-out	out	10.962	Saltbr-out	6.5276	HRD-in	-68.45, -50.57	72.29, 2.18	out-out-out	SNCooo	out-out	ActLoopNT-out	11.6458	ActLoopCT-out	nonTYR	APEdihe_aaiii	APEdist_nnoo	APE10-dihe-na	999.0, 102.39	APE9-dihe-na	-78.34, -151.63	APE8-dihe-in	-168.7, 144.18	APE8-rot-in	299.37	APE67-dihe-in	-66.82, -19.22	-122.77, 14.51	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	20.6219	APE9-dist-out	12.1907	None	None	None	XRAY	2.7	0.223	0.265	A	342.0	255.0	24	30	18	12	[[525, 791]]	1.0	3hmn	Homo sapiens	OTHER_TTK_HUMAN	CAMK	1.1e-53	188.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	3CEKA	P33981	519	794	857.0	No_ligand	No_ligand	Inactive	DFGin	4.1477	15.0877	ABAminus	-98.03, -14.36	-147.33, 142.24	-107.5, -0.94	300.98, 162.57	82.4, 8.93	out-out	out	11.1014	Saltbr-out	6.5727	HRD-in	-63.8, -55.54	78.98, -2.7	out-out-out	SNCooo	out-out	ActLoopNT-out	10.6408	ActLoopCT-out	nonTYR	APEdihe_aaoni	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, -140.03	APE8-dihe-out	-135.87, -42.68	APE8-rot-none	999.0	APE67-dihe-in	-70.42, -22.06	-66.07, -16.05	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	13.2773	None	None	None	XRAY	2.3	0.188	0.25	A	313.0	252.0	24	30	16	14	[[525, 791]]	1.0	3cek	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	3DBQA	P33981	515	796	857.0	No_ligand	No_ligand	Inactive	DFGin	4.218	15.6259	ABAminus	-82.17, -30.42	-141.36, 167.61	-106.63, 0.96	290.84, 175.03	70.86, 9.96	out-out	out	10.3514	Saltbr-out	6.591	HRD-in	-57.38, -50.92	66.46, 1.19	out-out-out	SNCooo	out-out	ActLoopNT-out	11.2541	ActLoopCT-out	nonTYR	APEdihe_aaiii	APEdist_nnoo	APE10-dihe-na	999.0, 166.38	APE9-dihe-na	117.73, 69.71	APE8-dihe-in	-75.54, 158.78	APE8-rot-in	302.2	APE67-dihe-in	-74.9, -25.39	-128.59, 17.55	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	18.7884	APE9-dist-out	11.7206	None	None	None	XRAY	2.7	0.226	0.285	A	343.0	259.0	23	30	18	12	[[525, 791]]	1.0	3dbq	Homo sapiens	OTHER_TTK_HUMAN	CAMK	1.1e-53	188.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	2ZMCA	P33981	516	794	857.0	No_ligand	No_ligand	Inactive	DFGin	4.045	15.3608	ABAminus	-102.63, 6.43	-172.08, 140.67	-107.12, 4.47	303.66, 149.3	60.1, 32.65	out-out	out	11.3165	Saltbr-out	5.811	HRD-in	-51.44, -51.77	70.45, 12.69	out-out-out	SNCooo	out-out	ActLoopNT-out	10.588	ActLoopCT-out	nonTYR	APEdihe_aaiii	APEdist_oooo	APE10-dihe-na	-148.16, 52.12	APE9-dihe-na	-110.91, 95.2	APE8-dihe-in	-78.12, 144.82	APE8-rot-in	328.93	APE67-dihe-in	-59.32, -21.8	-101.22, 8.95	APE12-dist-out	22.842	APE11-dist-out	21.0107	APE10-dist-out	19.4959	APE9-dist-out	11.4538	None	None	None	XRAY	3.14	0.226	0.289	A	390.0	260.0	19	30	21	9	[[525, 791]]	1.0	2zmc	Homo sapiens	OTHER_TTK_HUMAN	CAMK	1.7e-53	187.6	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	6GVJA	P33981	515	795	857.0	No_ligand	No_ligand	Inactive	DFGin	4.1899	15.3859	ABAminus	-94.09, -39.51	-142.2, 169.22	-115.27, 12.46	297.03, 156.51	66.91, 11.36	out-out	out	10.7254	Saltbr-out	9.2857	HRD-in	-64.5, -59.44	84.15, 4.87	out-out-out	SNCooo	out-out	ActLoopNT-out	11.8119	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_oooo	APE10-dihe-na	-96.72, 154.33	APE9-dihe-na	116.29, 95.4	APE8-dihe-in	-94.84, 145.96	APE8-rot-out	191.9	APE67-dihe-in	-63.51, -23.75	-95.29, 10.45	APE12-dist-out	22.0995	APE11-dist-out	23.6125	APE10-dist-out	18.8371	APE9-dist-out	11.483	None	None	None	XRAY	2.41	0.203	0.233	A	429.0	272.0	9	30	30	0	[[525, 791]]	1.0	6gvj	Homo sapiens	OTHER_TTK_HUMAN	CAMK	2.3e-53	187.2	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5NTTA	P33981	519	797	857.0	SVE:60801	Type1	Inactive	DFGin	4.0498	15.1203	ABAminus	-86.34, -42.9	-137.69, 167.25	-111.84, 11.03	299.57, 162.1	66.85, 16.85	out-out	out	10.9798	Saltbr-out	5.9222	HRD-in	-63.1, -49.38	74.04, 9.83	out-out-out	SNCooo	out-out	ActLoopNT-out	11.5008	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_oooo	APE10-dihe-na	-72.45, -49.0	APE9-dihe-na	-71.51, -26.39	APE8-dihe-in	-34.25, 137.42	APE8-rot-none	999.0	APE67-dihe-in	-68.38, -17.02	-109.78, 8.89	APE12-dist-out	22.2734	APE11-dist-out	18.5318	APE10-dist-out	15.6898	APE9-dist-out	11.5508	C604Y	TPO686	TPO686	XRAY	2.75	0.201	0.23	A	287.0	269.0	10	30	30	0	[[525, 791]]	1.0	5ntt	Homo sapiens	OTHER_TTK_HUMAN	CAMK	4.2e-54	189.5	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5LJJA	P33981	519	795	857.0	AD5:60901	Type1	Inactive	DFGin	4.3299	14.8533	ABAminus	-81.43, -35.19	-129.4, 134.9	-96.53, 6.93	283.88, 13.64	82.2, 19.77	out-out	out	10.0606	Saltbr-out	3.967	HRD-in	-54.64, -37.72	72.33, -52.21	out-out-out	SNCooo	out-out	ActLoopNT-out	12.1379	ActLoopCT-out	nonTYR	APEdihe_aaoii	APEdist_oooo	APE10-dihe-na	-74.59, 157.14	APE9-dihe-na	-95.35, -179.33	APE8-dihe-out	-73.32, -32.03	APE8-rot-in	319.71	APE67-dihe-in	-53.22, -30.68	-79.48, -20.83	APE12-dist-out	22.5363	APE11-dist-out	24.5732	APE10-dist-out	19.8838	APE9-dist-out	14.0722	C604Y	None	None	XRAY	3.0	0.228	0.268	A	313.0	260.0	17	30	25	5	[[525, 791]]	1.0	5ljj	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.7e-54	189.2	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5MRBA	P33981	519	795	857.0	C5N:60901	Type1	Inactive	DFGin	3.9904	15.0552	ABAminus	-88.14, -37.43	-145.51, 169.37	-114.29, 5.64	296.03, 167.61	72.21, 9.85	out-out	out	11.2038	Saltbr-out	6.0746	HRD-in	-67.77, -54.4	68.39, 11.32	out-out-out	SNCooo	out-out	ActLoopNT-out	11.0039	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nooo	APE10-dihe-na	-119.93, 125.86	APE9-dihe-na	65.05, 26.68	APE8-dihe-in	-57.09, 145.6	APE8-rot-out	189.99	APE67-dihe-in	-63.9, -20.76	-103.43, 7.11	APE12-dist-none	999.0	APE11-dist-out	21.193	APE10-dist-out	18.5012	APE9-dist-out	10.5598	C604Y	None	None	XRAY	2.2	0.175	0.216	A	313.0	259.0	18	30	25	5	[[525, 791]]	1.0	5mrb	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.7e-54	189.2	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5EH0A	P33981	516	794	857.0	5NW:801	Type1	Inactive	DFGin	4.285	14.957	ABAminus	-70.51, -43.24	-138.73, 164.35	-108.25, 7.22	296.58, 162.45	73.13, 1.25	out-out	out	10.7486	Saltbr-out	5.9776	HRD-in	-63.67, -57.11	75.04, -3.07	out-out-out	SNCooo	out-out	ActLoopNT-out	11.5337	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 128.74	APE8-dihe-in	-112.66, 155.78	APE8-rot-out	188.67	APE67-dihe-in	-62.69, -27.07	-106.54, 4.68	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	11.8837	None	None	None	XRAY	2.18	0.198	0.216	A	279.0	258.0	21	30	20	10	[[525, 791]]	1.0	5eh0	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.4e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	6H3KA	P33981	519	794	857.0	FMW:60801	Type1	Inactive	DFGin	4.2889	15.0597	ABAminus	-78.15, -56.1	-128.46, 166.12	-108.06, 3.12	300.73, 163.62	73.15, 6.23	out-out	out	10.843	Saltbr-out	5.6002	HRD-in	-55.05, -54.84	64.62, 9.92	out-out-out	SNCooo	out-out	ActLoopNT-out	11.8452	ActLoopCT-out	nonTYR	APEdihe_aanoi	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, 144.7	APE8-rot-out	181.2	APE67-dihe-in	-63.91, -24.73	-102.23, 3.19	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.48	0.209	0.231	A	279.0	254.0	22	30	18	12	[[525, 791]]	1.0	6h3k	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.4e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4JS8A	P33981	515	793	857.0	1PF:801	Type1	Inactive	DFGin	4.2459	15.0178	ABAminus	-84.57, -49.34	-133.98, 167.4	-109.17, 14.51	305.07, 151.28	67.69, 15.63	in-out	in	9.9926	Saltbr-out	6.6989	HRD-in	-62.96, -52.34	70.46, -10.5	out-out-out	SNCooo	out-out	ActLoopNT-out	12.0357	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, 112.01	APE9-dihe-na	-104.69, -175.56	APE8-dihe-in	-119.7, 153.55	APE8-rot-none	999.0	APE67-dihe-in	-65.36, -29.34	-115.57, 0.38	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	20.1985	APE9-dist-out	12.1114	None	TPO675,TPO686	TPO675,TPO686	XRAY	1.94	0.232	0.253	A	281.0	261.0	18	30	22	8	[[525, 791]]	1.0	4js8	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.6e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4JT3A	P33981	515	794	857.0	1PH:805	Type1	Inactive	DFGin	3.8684	14.8151	ABAminus	-98.39, -37.1	-134.23, 157.73	-105.72, 6.6	314.7, 129.31	71.51, 16.26	out-out	out	10.738	Saltbr-out	7.6842	HRD-in	-58.42, -47.48	62.69, -17.16	out-out-out	SNCooo	out-out	ActLoopNT-out	11.5117	ActLoopCT-out	nonTYR	APEdihe_aaooi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, -122.0	APE8-dihe-out	49.94, -124.02	APE8-rot-out	48.54	APE67-dihe-in	-61.75, -25.83	-97.12, 5.24	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	12.6794	None	None	None	XRAY	2.2	0.239	0.251	A	281.0	254.0	26	30	17	13	[[525, 791]]	1.0	4jt3	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.6e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4O6LA	P33981	515	793	857.0	2QK:1001	Type1	Inactive	DFGin	4.4074	15.1513	ABAminus	-90.1, -59.73	-114.17, 174.24	-104.1, 2.53	293.21, 159.51	80.72, 3.9	out-out	out	10.0489	Saltbr-out	6.4053	HRD-in	-59.12, -54.03	77.12, -18.06	out-out-out	SNCooo	out-out	ActLoopNT-out	12.3634	ActLoopCT-out	nonTYR	APEdihe_aanoi	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, 142.49	APE8-rot-out	181.91	APE67-dihe-in	-58.9, -26.81	-100.7, 0.85	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	TPO675,TPO676,SEP677	TPO675,TPO676,SEP677	XRAY	2.38	0.211	0.25	A	281.0	260.0	19	30	22	8	[[525, 791]]	1.0	4o6l	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.6e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4O6LB	P33981	515	793	857.0	2QK:1001	Type1	Inactive	DFGin	4.2812	15.0712	ABAminus	-86.79, -57.52	-123.5, 173.75	-102.84, -0.16	292.99, 165.07	73.6, 3.12	out-out	out	10.2905	Saltbr-out	6.2048	HRD-in	-50.51, -55.85	77.18, -15.75	out-out-out	SNCooo	out-out	ActLoopNT-out	11.3245	ActLoopCT-out	nonTYR	APEdihe_aaooi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 139.99	APE8-dihe-out	-73.42, -65.35	APE8-rot-out	60.02	APE67-dihe-in	-53.59, -30.18	-99.07, -3.9	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	12.391	None	TPO675,TPO676,SEP677	TPO675,TPO676,SEP677	XRAY	2.38	0.211	0.25	B	281.0	256.0	23	30	19	11	[[525, 791]]	1.0	4o6l	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.6e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4ZEGA	P33981	516	795	857.0	052:809	Type1	Inactive	DFGin	3.84	13.665	ABAminus	-89.35, -39.59	-147.37, 179.43	-120.68, 6.65	313.22, 129.95	72.3, 17.48	in-in	in	9.387	Saltbr-in	2.9346	HRD-in	-62.37, -56.18	83.02, -11.88	in-out-out	SNCioo	out-out	ActLoopNT-out	12.0247	ActLoopCT-out	nonTYR	APEdihe_aanoi	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, -10.83	APE8-rot-out	193.46	APE67-dihe-in	-54.14, -26.3	-124.62, 9.96	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.33	0.212	0.263	A	281.0	260.0	20	30	19	11	[[525, 791]]	1.0	4zeg	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.6e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	7CILA	P33981	515	795	857.0	FZR:801	Type1	Inactive	DFGin	3.9331	14.2557	ABAminus	-117.55, -29.06	-108.82, 151.92	-103.82, 8.49	303.9, 127.51	74.56, 17.84	in-in	in	9.4382	Saltbr-in	3.3648	HRD-in	-65.5, -48.3	84.67, -24.88	in-out-out	SNCioo	out-out	ActLoopNT-out	12.9001	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, 92.45	APE9-dihe-na	-62.61, -177.02	APE8-dihe-in	-129.03, 162.3	APE8-rot-none	999.0	APE67-dihe-in	-61.04, -14.98	-137.19, -4.93	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	20.1466	APE9-dist-out	12.9573	None	TPO686	TPO686	XRAY	2.3	0.213	0.246	A	281.0	265.0	16	30	21	9	[[525, 791]]	1.0	7cil	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.6e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	7CHNA	P33981	515	795	857.0	FZL:60801	Type1	Inactive	DFGin	4.1927	13.8065	ABAminus	-108.25, -28.45	-114.71, 169.67	-123.6, 14.83	311.38, 132.14	76.06, -17.71	in-out	in	9.5097	Saltbr-out	3.8365	HRD-in	-65.71, -57.35	92.03, -36.01	out-out-out	SNCooo	out-out	ActLoopNT-out	12.7753	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, 106.35	APE9-dihe-na	-38.75, 152.63	APE8-dihe-in	-100.45, 171.07	APE8-rot-none	999.0	APE67-dihe-in	-64.61, -12.97	-144.48, -3.21	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	19.7825	APE9-dist-out	12.3733	None	TPO675,TPO676,SEP677,TPO686	TPO675,TPO676,SEP677,TPO686	XRAY	2.4	0.209	0.256	A	282.0	265.0	16	30	26	4	[[525, 791]]	1.0	7chn	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.6e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	7CHTA	P33981	515	794	857.0	FZO:801	Type1	Inactive	DFGin	4.4498	14.1666	ABAminus	-112.95, -55.33	-89.89, 146.93	-112.72, 5.43	293.25, 164.69	101.6, -45.7	in-in	in	9.5394	Saltbr-in	3.3318	HRD-in	-54.87, -60.57	87.7, -19.09	in-out-none	SNCion	out-none	ActLoopNT-out	12.8282	ActLoopCT-none	nonTYR	APEdihe_aanni	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, -128.46	APE8-rot-none	999.0	APE67-dihe-in	-60.22, -14.09	-125.33, 1.76	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	TPO675,TPO676,SEP677,TPO686	TPO675,TPO676,SEP677,TPO686	XRAY	2.4	0.214	0.259	A	282.0	261.0	19	30	23	7	[[525, 791]]	1.0	7cht	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.6e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	7CJAA	P33981	515	795	857.0	G0U:60801	Type1	Inactive	DFGin	4.565	14.3804	ABAminus	-123.14, -50.22	-110.86, 109.05	-73.21, 16.92	303.06, 178.86	54.4, 45.65	in-in	in	9.4206	Saltbr-in	3.1362	HRD-in	-56.29, -55.19	87.57, -24.84	in-out-out	SNCioo	out-out	ActLoopNT-out	12.6282	ActLoopCT-out	nonTYR	APEdihe_aaoni	APEdist_nnoo	APE10-dihe-na	999.0, -106.12	APE9-dihe-na	88.75, 151.9	APE8-dihe-out	-119.49, -174.64	APE8-rot-none	999.0	APE67-dihe-in	-62.96, -21.71	-126.19, -8.32	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	19.6901	APE9-dist-out	13.0613	None	TPO675,TPO676,SEP677,TPO686	TPO675,TPO676,SEP677,TPO686	XRAY	2.49	0.212	0.253	A	283.0	263.0	18	30	22	8	[[525, 791]]	1.0	7cja	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.7e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	7CLHA	P33981	516	795	857.0	G5C:801	Type1	Inactive	DFGin	4.3116	14.6343	ABAminus	-128.87, -39.46	-112.78, 121.46	-81.6, 17.57	300.39, 1.38	66.14, 9.26	out-out	out	10.9601	Saltbr-out	4.4183	HRD-in	-65.1, -39.58	41.54, 27.85	out-out-out	SNCooo	out-out	ActLoopNT-out	12.3383	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, 124.23	APE9-dihe-na	-106.52, -148.21	APE8-dihe-in	-158.76, 155.6	APE8-rot-none	999.0	APE67-dihe-in	-62.14, -23.44	-138.79, 13.28	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	20.4761	APE9-dist-out	12.4508	None	TPO675,TPO676,SEP677,TPO686	TPO675,TPO676,SEP677,TPO686	XRAY	2.9	0.21	0.272	A	283.0	260.0	20	30	21	9	[[525, 791]]	1.0	7clh	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.7e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4D2SA	P33981	513	793	857.0	DYK:1794	Type1	Inactive	DFGin	4.2732	14.7666	ABAminus	-95.21, -44.96	-135.94, 172.0	-115.3, 6.49	305.25, 149.5	77.48, -1.71	out-out	out	10.7098	Saltbr-out	6.6144	HRD-in	-50.94, -45.09	68.46, -25.84	out-none-out	SNCono	none-out	ActLoopNT-none	999.0	ActLoopCT-out	nonTYR	APEdihe_aanoi	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, 127.79	APE8-rot-out	187.01	APE67-dihe-in	-52.43, -42.93	-100.42, -1.9	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.5	0.181	0.221	A	284.0	249.0	32	30	13	17	[[525, 791]]	1.0	4d2s	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.8e-54	189.0	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	6TN9A	P33981	515	794	857.0	NN5:60901	Type1	Inactive	DFGin	4.4623	14.4733	ABAminus	-102.75, -43.17	-113.58, 151.32	-116.65, 21.41	306.29, 152.97	57.99, 34.15	in-out	in	9.9847	Saltbr-out	5.9616	HRD-in	-27.83, -60.59	74.73, -24.14	out-out-out	SNCooo	out-out	ActLoopNT-out	12.0589	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnoo	APE10-dihe-na	999.0, 137.59	APE9-dihe-na	-76.58, 147.78	APE8-dihe-in	-71.18, 119.63	APE8-rot-out	196.33	APE67-dihe-in	-109.27, 4.01	-95.26, 38.71	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	20.0955	APE9-dist-out	12.4585	None	None	None	XRAY	2.6	0.22	0.265	A	294.0	257.0	23	30	16	14	[[525, 791]]	1.0	6tn9	Homo sapiens	OTHER_TTK_HUMAN	CAMK	6.6e-54	188.9	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	6TNCA	P33981	516	794	857.0	O23:901	Type1	Inactive	DFGin	3.8222	13.2707	ABAminus	-102.01, -20.32	-149.44, 176.26	-124.03, 9.64	314.66, 123.73	67.72, 11.06	in-in	in	9.5574	Saltbr-in	2.629	HRD-in	-64.18, -55.18	74.7, 4.91	in-out-out	SNCioo	out-out	ActLoopNT-out	11.7796	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, -38.28	APE9-dihe-na	92.43, 140.71	APE8-dihe-in	-88.61, 139.32	APE8-rot-none	999.0	APE67-dihe-in	-66.01, -24.33	-119.33, 14.55	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	21.1573	APE9-dist-out	12.4568	None	TPO686	TPO686	XRAY	2.3	0.189	0.236	A	294.0	259.0	20	30	20	10	[[525, 791]]	1.0	6tnc	Homo sapiens	OTHER_TTK_HUMAN	CAMK	6.6e-54	188.9	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	6N6OA	P33981	515	794	857.0	KE7:801	Type1	Inactive	DFGin	4.2196	15.0738	ABAminus	-105.7, -27.81	-128.43, 140.87	-98.61, 4.99	296.05, 169.82	72.39, 7.89	out-out	out	11.0004	Saltbr-out	6.7761	HRD-in	-62.81, -50.74	78.47, -21.46	out-out-none	SNCoon	out-none	ActLoopNT-out	12.0654	ActLoopCT-none	nonTYR	APEdihe_aanni	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, 115.88	APE8-rot-none	999.0	APE67-dihe-in	-66.56, -23.16	-93.67, -1.52	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.6	0.202	0.244	A	285.0	254.0	26	30	14	16	[[525, 791]]	1.0	6n6o	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.9e-54	189.0	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	3GFWA	P33981	519	794	857.0	S22:60001	Type1	Inactive	DFGin	4.0966	15.4766	ABAminus	-102.94, -15.31	-151.43, 156.9	-123.98, 8.09	299.84, 155.88	79.83, 9.4	out-out	out	11.3341	Saltbr-out	6.8637	HRD-in	-62.59, -52.13	64.76, 15.17	out-none-out	SNCono	none-out	ActLoopNT-none	999.0	ActLoopCT-out	nonTYR	APEdihe_aaoni	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, -173.82	APE8-dihe-out	-84.76, -70.14	APE8-rot-none	999.0	APE67-dihe-in	-56.76, -41.42	-66.21, -14.77	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	12.9545	None	None	None	XRAY	2.74	0.206	0.239	A	313.0	249.0	27	30	14	16	[[525, 791]]	1.0	3gfw	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4BHZA	P33981	519	794	857.0	Z0B:61797	Type1	Inactive	DFGin	3.814	15.1497	ABAminus	-70.44, -40.37	-152.25, 172.63	-109.58, -2.5	303.76, 168.45	78.58, 3.35	out-out	out	11.1106	Saltbr-out	6.7851	HRD-in	-65.48, -51.8	72.15, -21.43	out-out-out	SNCooo	out-out	ActLoopNT-out	11.6571	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nooo	APE10-dihe-na	-146.03, 131.66	APE9-dihe-na	99.43, -38.47	APE8-dihe-in	-33.12, 126.88	APE8-rot-out	212.76	APE67-dihe-in	-59.36, -27.47	-101.37, 0.38	APE12-dist-none	999.0	APE11-dist-out	16.9031	APE10-dist-out	14.3888	APE9-dist-out	10.5608	None	None	None	XRAY	2.85	0.189	0.23	A	313.0	248.0	28	30	18	12	[[525, 791]]	1.0	4bhz	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4BI0A	P33981	519	794	857.0	Z0W:61797	Type1	Inactive	DFGin	3.8287	15.1412	ABAminus	-77.7, -43.35	-147.59, 168.95	-104.67, -7.65	305.3, 161.34	84.08, 0.49	out-out	out	11.2167	Saltbr-out	6.6201	HRD-in	-66.77, -48.18	66.87, -13.99	out-out-out	SNCooo	out-out	ActLoopNT-out	11.707	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nooo	APE10-dihe-na	-172.15, 129.89	APE9-dihe-na	90.95, -5.9	APE8-dihe-in	-61.15, 137.1	APE8-rot-out	197.64	APE67-dihe-in	-62.02, -25.36	-102.46, -0.21	APE12-dist-none	999.0	APE11-dist-out	17.6319	APE10-dist-out	14.5074	APE9-dist-out	10.2609	None	None	None	XRAY	2.84	0.186	0.224	A	313.0	251.0	25	30	18	12	[[525, 791]]	1.0	4bi0	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4BI1A	P33981	519	794	857.0	ZO6:61797	Type1	Inactive	DFGin	3.9522	15.1631	ABAminus	-88.37, -33.85	-141.98, 170.47	-111.95, -2.75	300.7, 163.09	85.15, 1.05	out-out	out	11.0133	Saltbr-out	6.7454	HRD-in	-63.61, -47.43	80.83, -10.06	out-out-out	SNCooo	out-out	ActLoopNT-out	11.7435	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nooo	APE10-dihe-na	-95.81, 104.37	APE9-dihe-na	60.87, 40.67	APE8-dihe-in	-72.34, 145.56	APE8-rot-out	202.94	APE67-dihe-in	-59.86, -24.34	-106.41, -1.69	APE12-dist-none	999.0	APE11-dist-out	16.4744	APE10-dist-out	16.2766	APE9-dist-out	9.9811	None	None	None	XRAY	2.7	0.19	0.228	A	313.0	249.0	27	30	17	13	[[525, 791]]	1.0	4bi1	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4BI2A	P33981	519	794	857.0	ZO8:61797	Type1	Inactive	DFGin	3.6197	15.1474	ABAminus	-76.55, -49.66	-141.71, 170.77	-111.27, 13.59	318.83, 139.2	57.0, 30.87	out-out	out	11.3366	Saltbr-out	7.1063	HRD-in	-54.6, -40.14	69.57, -18.49	out-out-out	SNCooo	out-out	ActLoopNT-out	11.7154	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nooo	APE10-dihe-na	-155.03, 149.01	APE9-dihe-na	97.44, -33.31	APE8-dihe-in	-41.38, 118.56	APE8-rot-out	207.3	APE67-dihe-in	-61.97, -21.49	-89.45, -2.47	APE12-dist-none	999.0	APE11-dist-out	17.1053	APE10-dist-out	13.3877	APE9-dist-out	10.3629	None	None	None	XRAY	3.11	0.195	0.226	A	313.0	250.0	26	30	17	13	[[525, 791]]	1.0	4bi2	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4C4EA	P33981	519	794	857.0	4T9:61796	Type1	Inactive	DFGin	4.0304	15.1877	ABAminus	-90.34, -24.49	-149.19, 168.21	-113.7, 5.3	302.17, 159.25	73.5, 10.67	out-out	out	11.1006	Saltbr-out	6.8613	HRD-in	-63.89, -49.54	74.97, -11.85	out-out-out	SNCooo	out-out	ActLoopNT-out	11.8306	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nooo	APE10-dihe-na	-179.93, 127.94	APE9-dihe-na	94.59, -22.08	APE8-dihe-in	-45.98, 144.24	APE8-rot-none	999.0	APE67-dihe-in	-66.59, -18.55	-116.67, 4.35	APE12-dist-none	999.0	APE11-dist-out	17.2125	APE10-dist-out	14.589	APE9-dist-out	10.4262	None	TPO686	TPO686	XRAY	2.6	0.188	0.212	A	313.0	254.0	22	30	21	9	[[525, 791]]	1.0	4c4e	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4C4FA	P33981	519	794	857.0	7CE:61799	Type1	Inactive	DFGin	4.1032	15.2155	ABAminus	-101.62, -18.54	-147.87, 165.66	-113.0, 7.85	297.15, 168.51	67.15, 10.57	out-out	out	11.1151	Saltbr-out	6.3853	HRD-in	-61.91, -51.34	67.18, 3.65	out-out-out	SNCooo	out-out	ActLoopNT-out	11.6937	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nooo	APE10-dihe-na	-53.1, 141.36	APE9-dihe-na	95.36, -36.89	APE8-dihe-in	-36.14, 134.58	APE8-rot-none	999.0	APE67-dihe-in	-62.14, -22.97	-109.48, -8.06	APE12-dist-none	999.0	APE11-dist-out	16.9493	APE10-dist-out	13.6166	APE9-dist-out	10.4933	None	TPO686	TPO686	XRAY	2.36	0.193	0.222	A	313.0	251.0	25	30	18	12	[[525, 791]]	1.0	4c4f	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4C4GA	P33981	519	794	857.0	7RO:61796	Type1	Inactive	DFGin	3.9507	14.9105	ABAminus	-95.92, -23.51	-152.6, 169.34	-115.91, 15.19	313.37, 131.38	68.79, 7.18	out-out	out	10.4725	Saltbr-out	6.4011	HRD-in	-66.58, -56.34	70.86, -10.66	out-none-out	SNCono	none-out	ActLoopNT-none	999.0	ActLoopCT-out	nonTYR	APEdihe_aaono	APEdist_nnoo	APE10-dihe-na	999.0, -23.29	APE9-dihe-na	75.51, 47.64	APE8-dihe-out	-83.97, -34.84	APE8-rot-none	999.0	APE67-dihe-out	-67.58, -18.15	68.34, -13.32	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	15.7424	APE9-dist-out	10.0984	None	TPO686	TPO686	XRAY	2.65	0.194	0.223	A	313.0	248.0	28	30	15	15	[[525, 791]]	1.0	4c4g	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4C4HA	P33981	519	794	857.0	7RO:61795	Type1	Inactive	DFGin	3.9512	14.7878	ABAminus	-80.93, -53.88	-130.38, 169.34	-111.71, 6.58	311.9, 132.59	84.63, -4.86	out-out	out	10.6984	Saltbr-out	6.3463	HRD-in	-63.34, -62.87	84.67, -29.96	out-none-out	SNCono	none-out	ActLoopNT-none	999.0	ActLoopCT-out	nonTYR	APEdihe_aanoi	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, 148.95	APE8-rot-out	194.44	APE67-dihe-in	-60.4, -21.07	-128.85, -4.66	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.8	0.199	0.241	A	313.0	245.0	31	30	13	17	[[525, 791]]	1.0	4c4h	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4C4IA	P33981	519	794	857.0	X20:61795	Type1	Inactive	DFGin	4.0896	14.9117	ABAminus	-85.8, -40.53	-139.92, 167.53	-117.17, 9.6	306.74, 149.34	84.49, -23.76	out-out	out	10.6367	Saltbr-out	5.823	HRD-in	-64.02, -48.25	79.16, -8.53	out-out-out	SNCooo	out-out	ActLoopNT-out	9.7954	ActLoopCT-out	nonTYR	APEdihe_aanoi	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, 148.09	APE8-rot-out	199.19	APE67-dihe-in	-59.18, -16.03	-127.61, 0.23	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.65	0.192	0.213	A	313.0	250.0	26	30	16	14	[[525, 791]]	1.0	4c4i	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4C4JA	P33981	519	794	857.0	X21:61795	Type1	Inactive	DFGin	4.4038	13.9195	ABAminus	-109.95, -30.18	-116.46, 149.35	-120.89, 12.34	310.2, 113.73	68.77, 1.44	in-in	in	9.3376	Saltbr-in	2.8087	HRD-in	-65.51, -59.05	77.98, -5.37	in-out-out	SNCioo	out-out	ActLoopNT-out	12.2944	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, 21.19	APE9-dihe-na	-150.7, 175.28	APE8-dihe-in	-114.81, 156.56	APE8-rot-none	999.0	APE67-dihe-in	-60.74, -34.36	-112.12, -16.33	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	17.8481	APE9-dist-out	12.2327	None	TPO686	TPO686	XRAY	2.5	0.194	0.21	A	313.0	259.0	17	30	22	8	[[525, 791]]	1.0	4c4j	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4CV8A	P33981	519	794	857.0	3D7:61795	Type1	Inactive	DFGin	4.1365	15.2721	ABAminus	-101.65, -40.07	-103.15, 134.35	-95.86, -0.86	282.15, 159.92	70.87, 15.07	out-none	out	10.3792	Saltbr-none	999.0	HRD-in	-64.98, -43.27	71.23, -61.83	none-out-out	SNCnoo	out-out	ActLoopNT-out	11.8569	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 73.12	APE8-dihe-in	-68.11, 137.84	APE8-rot-out	188.9	APE67-dihe-in	-71.84, -5.33	-100.06, 9.29	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	12.5295	None	None	None	XRAY	3.0	0.182	0.226	A	313.0	252.0	24	30	17	13	[[525, 791]]	1.0	4cv8	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4CV9A	P33981	519	794	857.0	W2K:61795	Type1	Inactive	DFGin	4.2474	15.0389	ABAminus	-101.91, -20.01	-131.88, 149.02	-113.92, 7.67	289.67, 174.21	75.29, -6.63	out-out	out	10.2073	Saltbr-out	6.3515	HRD-in	-64.0, -47.62	80.61, -7.87	out-out-out	SNCooo	out-out	ActLoopNT-out	11.6669	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, 146.4	APE9-dihe-na	-66.62, 130.4	APE8-dihe-in	-114.41, 114.43	APE8-rot-none	999.0	APE67-dihe-in	-66.76, -19.17	-78.46, 1.95	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	19.3938	APE9-dist-out	11.2853	None	TPO686	TPO686	XRAY	2.5	0.188	0.232	A	313.0	251.0	25	30	16	14	[[525, 791]]	1.0	4cv9	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	4CVAA	P33981	519	794	857.0	WBI:61795	Type1	Inactive	DFGin	4.1371	15.0836	ABAminus	-103.64, -29.1	-121.8, 152.79	-114.4, 8.52	290.87, 175.57	75.57, -11.77	out-out	out	10.5105	Saltbr-out	6.7222	HRD-in	-51.45, -55.15	67.0, 6.09	out-out-out	SNCooo	out-out	ActLoopNT-out	11.9303	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, 131.79	APE9-dihe-na	-118.82, 123.96	APE8-dihe-in	-82.49, 163.19	APE8-rot-none	999.0	APE67-dihe-in	-61.35, -24.47	-128.46, -2.58	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	20.162	APE9-dist-out	11.8818	None	TPO686	TPO686	XRAY	2.5	0.191	0.215	A	313.0	251.0	25	30	16	14	[[525, 791]]	1.0	4cva	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5AP0A	P33981	519	795	857.0	AU5:61795	Type1	Inactive	DFGin	3.9783	15.0028	ABAminus	-96.76, -22.08	-146.7, 164.38	-110.23, 9.55	298.65, 161.95	70.1, 0.89	out-out	out	11.0296	Saltbr-out	6.0499	HRD-in	-65.89, -53.49	72.58, -3.97	out-out-out	SNCooo	out-out	ActLoopNT-out	11.6332	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nooo	APE10-dihe-na	-63.25, 124.33	APE9-dihe-na	59.83, 23.25	APE8-dihe-in	-63.91, 141.71	APE8-rot-none	999.0	APE67-dihe-in	-66.96, -16.22	-115.17, -7.01	APE12-dist-none	999.0	APE11-dist-out	16.0418	APE10-dist-out	15.6429	APE9-dist-out	10.4402	None	TPO686	TPO686	XRAY	2.15	0.186	0.22	A	313.0	252.0	25	30	17	13	[[525, 791]]	1.0	5ap0	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5AP1A	P33981	519	795	857.0	O38:61796	Type1	Inactive	DFGin	4.1088	14.7281	ABAminus	-89.0, -45.75	-136.45, 170.67	-110.11, 13.99	300.68, 155.11	70.41, 10.72	in-out	in	9.6633	Saltbr-out	6.1057	HRD-in	-65.37, -51.62	69.07, -9.73	out-out-out	SNCooo	out-out	ActLoopNT-out	12.2118	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, 139.28	APE9-dihe-na	-84.72, -171.47	APE8-dihe-in	-119.66, 146.5	APE8-rot-none	999.0	APE67-dihe-in	-60.78, -20.45	-114.29, -8.4	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	19.8656	APE9-dist-out	12.4044	None	TPO675,TPO676,SEP677,TPO686	TPO675,TPO676,SEP677,TPO686	XRAY	2.05	0.195	0.211	A	313.0	268.0	9	30	28	2	[[525, 791]]	1.0	5ap1	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5AP2A	P33981	519	794	857.0	PWU:61795	Type1	Inactive	DFGin	3.691	14.021	ABAminus	-79.91, -47.41	-141.0, 175.42	-113.38, 7.32	320.57, 109.97	89.57, -32.6	in-in	in	9.7242	Saltbr-in	3.3984	HRD-in	-63.17, -34.41	72.38, -58.43	in-out-out	SNCioo	out-out	ActLoopNT-out	12.8241	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 169.79	APE8-dihe-in	-98.15, 169.16	APE8-rot-out	194.76	APE67-dihe-in	-65.72, -14.71	-128.84, -2.63	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	12.6585	None	None	None	XRAY	2.8	0.197	0.254	A	313.0	253.0	23	30	20	10	[[525, 791]]	1.0	5ap2	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5EHLA	P33981	519	796	857.0	0SQ:60901	Type1	Inactive	DFGin	4.2744	15.1576	ABAminus	-89.17, -26.97	-144.84, 160.15	-105.67, 2.47	304.42, 164.14	76.44, 12.25	out-none	out	10.8654	Saltbr-none	999.0	HRD-in	-63.29, -42.93	60.48, 0.47	none-out-out	SNCnoo	out-out	ActLoopNT-out	11.3913	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnoo	APE10-dihe-na	999.0, 165.8	APE9-dihe-na	-68.76, 160.5	APE8-dihe-in	-124.68, 151.59	APE8-rot-out	183.98	APE67-dihe-in	-53.53, -39.03	-99.14, 4.43	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	20.2412	APE9-dist-out	11.8872	None	None	None	XRAY	2.66	0.19	0.219	A	313.0	254.0	24	30	16	14	[[525, 791]]	1.0	5ehl	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5EHOA	P33981	519	794	857.0	5O1:60901	Type1	Inactive	DFGin	4.2634	15.0938	ABAminus	-83.34, -43.93	-140.36, 165.0	-106.3, 14.68	297.32, 167.25	72.3, 14.29	out-out	out	10.1676	Saltbr-out	6.5391	HRD-in	-62.9, -44.14	61.17, -2.98	out-out-out	SNCooo	out-out	ActLoopNT-out	12.1874	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnoo	APE10-dihe-na	999.0, 139.96	APE9-dihe-na	-95.06, 170.77	APE8-dihe-in	-134.87, 145.83	APE8-rot-out	174.69	APE67-dihe-in	-61.39, -34.62	-100.96, 10.08	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	19.4357	APE9-dist-out	11.772	None	None	None	XRAY	2.18	0.191	0.207	A	313.0	255.0	21	30	21	9	[[525, 791]]	1.0	5eho	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5EHYA	P33981	519	794	857.0	5O4:60908	Type1	Inactive	DFGin	4.042	15.1214	ABAminus	-87.29, -30.75	-144.51, 167.55	-109.84, 1.63	297.04, 168.45	76.09, -1.53	out-out	out	11.2157	Saltbr-out	6.3503	HRD-in	-65.33, -49.5	72.61, -2.8	out-out-out	SNCooo	out-out	ActLoopNT-out	11.8801	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnoo	APE10-dihe-na	999.0, 156.37	APE9-dihe-na	-85.3, 71.37	APE8-dihe-in	-68.61, 143.92	APE8-rot-out	179.84	APE67-dihe-in	-62.19, -35.71	-100.46, 6.76	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	18.1247	APE9-dist-out	9.939	None	None	None	XRAY	2.26	0.186	0.207	A	313.0	251.0	25	30	17	13	[[525, 791]]	1.0	5ehy	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5EI2A	P33981	516	794	857.0	5O7:901	Type1	Inactive	DFGin	3.9798	14.4755	ABAminus	-78.73, -52.63	-139.31, 160.64	-92.52, 2.93	318.22, 95.84	89.08, -7.34	out-out	out	10.4295	Saltbr-out	5.6581	HRD-in	-63.78, -50.07	70.22, -0.8	out-out-out	SNCooo	out-out	ActLoopNT-out	13.0351	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 160.32	APE8-dihe-in	-73.87, 160.97	APE8-rot-out	191.53	APE67-dihe-in	-64.29, -11.12	-129.83, -10.54	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	12.0301	None	None	None	XRAY	2.67	0.239	0.295	A	313.0	256.0	23	30	18	12	[[525, 791]]	1.0	5ei2	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5EI6A	P33981	519	794	857.0	5OQ:60901	Type1	Inactive	DFGin	3.9312	14.3472	ABAminus	-86.7, -33.46	-148.62, 167.92	-109.74, 12.61	310.8, 112.58	71.78, 5.46	in-out	in	9.9878	Saltbr-out	6.0297	HRD-in	-61.95, -54.54	69.88, -0.42	out-out-out	SNCooo	out-out	ActLoopNT-out	12.5318	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_oooo	APE10-dihe-na	-56.47, 134.25	APE9-dihe-na	-152.35, -175.71	APE8-dihe-in	-158.59, 132.95	APE8-rot-out	189.02	APE67-dihe-in	-61.48, -23.02	-109.15, 7.83	APE12-dist-out	18.7093	APE11-dist-out	20.4334	APE10-dist-out	18.8255	APE9-dist-out	11.9616	None	None	None	XRAY	2.01	0.198	0.221	A	313.0	261.0	15	30	25	5	[[525, 791]]	1.0	5ei6	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5EI8A	P33981	519	753	857.0	5OE:60901	Type1	Inactive	DFGin	4.2811	14.7695	ABAminus	-81.34, -45.63	-150.03, 174.99	-111.39, 21.62	317.11, 77.36	57.79, 25.49	out-out	out	10.3556	Saltbr-out	5.3615	HRD-in	-63.47, -50.78	71.71, -3.86	out-out-out	SNCooo	out-out	ActLoopNT-out	13.1071	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnoo	APE10-dihe-na	999.0, 107.39	APE9-dihe-na	-134.97, 110.16	APE8-dihe-in	-74.95, 151.91	APE8-rot-out	195.72	APE67-dihe-in	-64.93, -13.34	-115.39, 3.38	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	17.0382	APE9-dist-out	11.8053	None	None	None	XRAY	2.17	0.216	0.244	A	313.0	216.0	19	30	21	9	[[525, 791]]	1.0	5ei8	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5N87A	P33981	519	794	857.0	N66:60901	Type1	Inactive	DFGin	4.1741	15.0993	ABAminus	-88.48, -35.42	-150.02, 176.97	-116.22, 4.15	297.47, 158.19	69.2, 16.91	out-out	out	11.1121	Saltbr-out	6.4627	HRD-in	-74.45, -55.5	72.51, 8.91	out-out-out	SNCooo	out-out	ActLoopNT-out	11.4588	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nooo	APE10-dihe-na	-86.47, 133.33	APE9-dihe-na	70.41, 9.01	APE8-dihe-in	-52.47, 143.66	APE8-rot-none	999.0	APE67-dihe-in	-68.74, -15.33	-108.1, -7.79	APE12-dist-none	999.0	APE11-dist-out	18.0335	APE10-dist-out	15.2021	APE9-dist-out	9.8451	None	TPO686	TPO686	XRAY	2.29	0.2	0.238	A	313.0	253.0	23	30	18	12	[[525, 791]]	1.0	5n87	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5AP6A	P33981	519	794	857.0	PWU:61795	Type1	Inactive	DFGin	4.0071	14.3006	ABAminus	-114.86, -13.47	-145.86, 158.61	-108.81, 9.51	308.42, 109.78	72.17, 20.89	in-in	in	9.9065	Saltbr-in	2.9635	HRD-in	-61.13, -55.8	72.48, -11.9	in-out-out	SNCioo	out-out	ActLoopNT-out	12.9974	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_oooo	APE10-dihe-na	-48.78, 124.97	APE9-dihe-na	-141.21, -168.37	APE8-dihe-in	-169.63, 134.85	APE8-rot-out	190.42	APE67-dihe-in	-54.56, -26.33	-104.78, -10.65	APE12-dist-out	18.0487	APE11-dist-out	19.9004	APE10-dist-out	18.3065	APE9-dist-out	11.7896	C604W	None	None	XRAY	2.1	0.183	0.209	A	313.0	259.0	17	30	24	6	[[525, 791]]	1.0	5ap6	Homo sapiens	OTHER_TTK_HUMAN	CAMK	2.5e-53	187.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5AP7A	P33981	519	794	857.0	SVE:61795	Type1	Inactive	DFGin	4.0075	15.0106	ABAminus	-75.4, -47.55	-134.63, 175.4	-113.35, 2.93	298.14, 169.12	68.03, 11.08	out-out	out	11.2161	Saltbr-out	6.2883	HRD-in	-53.42, -53.82	66.3, 10.85	out-out-out	SNCooo	out-out	ActLoopNT-out	11.4759	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnoo	APE10-dihe-na	999.0, -94.63	APE9-dihe-na	-108.3, 120.24	APE8-dihe-in	-73.36, 151.59	APE8-rot-out	193.39	APE67-dihe-in	-46.84, -28.38	-104.91, -10.44	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	17.4934	APE9-dist-out	10.1157	C604W	None	None	XRAY	2.45	0.188	0.234	A	313.0	253.0	23	30	20	10	[[525, 791]]	1.0	5ap7	Homo sapiens	OTHER_TTK_HUMAN	CAMK	2.5e-53	187.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5O91A	P33981	519	796	857.0	C5N:60901	Type1	Inactive	DFGin	3.802	15.016	ABAminus	-78.15, -40.0	-151.19, 165.46	-106.99, 8.04	304.83, 159.67	51.06, 36.71	out-out	out	11.1062	Saltbr-out	6.4839	HRD-in	-71.98, -51.24	56.1, 25.02	out-out-out	SNCooo	out-out	ActLoopNT-out	11.3197	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nooo	APE10-dihe-na	-75.68, 72.2	APE9-dihe-na	66.53, 36.69	APE8-dihe-in	-74.19, 134.73	APE8-rot-out	176.75	APE67-dihe-in	-60.61, -35.71	-97.24, 8.51	APE12-dist-none	999.0	APE11-dist-out	17.7543	APE10-dist-out	18.9871	APE9-dist-out	10.2058	C604W	None	None	XRAY	3.2	0.214	0.254	A	313.0	261.0	17	30	24	6	[[525, 791]]	1.0	5o91	Homo sapiens	OTHER_TTK_HUMAN	CAMK	2.5e-53	187.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	6B4WA	P33981	515	793	857.0	CQ7:801	Type1	Inactive	DFGin	4.7938	13.168	ABAminus	-124.9, -1.56	-141.04, 152.98	-122.68, 8.74	304.31, 73.0	58.44, 34.07	in-none	in	9.9845	Saltbr-none	999.0	HRD-in	-75.92, -62.4	70.1, 24.42	none-out-out	SNCnoo	out-out	ActLoopNT-out	12.6411	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnoo	APE10-dihe-na	999.0, 142.31	APE9-dihe-na	-91.61, 164.96	APE8-dihe-in	-76.84, 169.09	APE8-rot-out	57.53	APE67-dihe-in	-71.32, -26.48	-122.98, 9.12	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	20.419	APE9-dist-out	13.2234	None	None	None	XRAY	2.9	0.194	0.253	A	303.0	259.0	20	30	21	9	[[525, 791]]	1.0	6b4w	Homo sapiens	OTHER_TTK_HUMAN	CAMK	7.4e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	2X9EA	P33981	515	795	857.0	SVE:1796	Type1	Inactive	DFGin	3.5234	14.6918	ABAminus	-97.78, -42.88	-144.87, 174.21	-107.75, 2.72	297.55, 168.15	71.6, 31.63	out-out	out	11.0537	Saltbr-out	5.6713	HRD-in	-68.71, -48.71	69.68, -10.51	out-out-out	SNCooo	out-out	ActLoopNT-out	11.5166	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 32.06	APE8-dihe-in	-85.14, 170.49	APE8-rot-out	171.47	APE67-dihe-in	-39.15, -60.16	-95.37, -10.13	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	11.7324	None	None	None	XRAY	3.1	0.215	0.306	A	317.0	254.0	27	30	15	15	[[525, 791]]	1.0	2x9e	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.7e-54	188.5	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	3VQUA	P33981	516	795	857.0	O22:909	Type1	Inactive	DFGin	3.9763	14.9659	ABAminus	-81.75, -53.65	-129.74, 172.69	-111.26, 9.8	306.0, 159.19	69.59, 10.96	out-out	out	10.3421	Saltbr-out	6.0544	HRD-out	-61.39, 148.14	-116.24, 0.39	out-out-out	SNCooo	out-out	ActLoopNT-out	11.8806	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 166.62	APE8-dihe-in	-143.47, 148.23	APE8-rot-out	189.58	APE67-dihe-in	-60.98, -38.83	-96.2, 17.0	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	12.1343	None	None	None	XRAY	2.4	0.251	0.284	A	320.0	258.0	22	30	20	10	[[525, 791]]	1.0	3vqu	Homo sapiens	OTHER_TTK_HUMAN	CAMK	9e-54	188.5	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	3WYXA	P33981	516	795	857.0	O38:902	Type1	Inactive	DFGin	3.839	14.4009	ABAminus	-92.88, -48.98	-138.38, 177.59	-116.03, 10.0	308.72, 129.43	75.11, 2.89	in-out	in	9.7357	Saltbr-out	5.9966	HRD-out	-64.04, 113.3	-83.23, 11.65	out-out-out	SNCooo	out-out	ActLoopNT-out	12.0726	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 88.77	APE8-dihe-in	-123.04, 145.7	APE8-rot-out	168.34	APE67-dihe-in	-60.5, -36.82	-102.78, 9.66	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	11.6667	None	None	None	XRAY	2.9	0.234	0.273	A	321.0	258.0	22	30	19	11	[[525, 791]]	1.0	3wyx	Homo sapiens	OTHER_TTK_HUMAN	CAMK	9.1e-54	188.4	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	3WYYA	P33981	516	795	857.0	O17:901	Type1	Inactive	DFGin	3.9824	14.4179	ABAminus	-85.96, -42.58	-150.53, 171.45	-108.18, 9.47	313.94, 99.77	63.89, 38.79	in-out	in	9.4486	Saltbr-out	5.5718	HRD-out	-71.41, 84.78	-72.82, 23.64	out-out-out	SNCooo	out-out	ActLoopNT-out	12.3411	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 114.86	APE8-dihe-in	-127.04, 157.36	APE8-rot-out	170.56	APE67-dihe-in	-53.64, -55.08	-100.41, 9.5	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	11.8347	None	None	None	XRAY	3.05	0.229	0.281	A	321.0	258.0	22	30	19	11	[[525, 791]]	1.0	3wyy	Homo sapiens	OTHER_TTK_HUMAN	CAMK	9.1e-54	188.4	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5N7VA	P33981	519	794	857.0	8PT:60901	Type1	Inactive	DFGin	3.9799	14.7625	ABAminus	-96.64, -47.45	-131.22, 170.52	-125.08, -20.32	308.53, 165.4	127.69, 98.89	out-out	out	11.1165	Saltbr-out	6.0234	HRD-in	-71.01, -50.2	68.87, 0.08	out-out-out	SNCooo	out-out	ActLoopNT-out	11.9896	ActLoopCT-out	nonTYR	APEdihe_aaono	APEdist_oooo	APE10-dihe-na	-107.54, -172.28	APE9-dihe-na	75.07, -51.21	APE8-dihe-out	34.13, -74.99	APE8-rot-none	999.0	APE67-dihe-out	-102.08, -11.37	79.21, 21.03	APE12-dist-out	19.2341	APE11-dist-out	17.281	APE10-dist-out	12.4427	APE9-dist-out	10.0448	None	TPO686	TPO686	XRAY	2.52	0.198	0.278	A	313.0	258.0	18	30	23	7	[[525, 791]]	1.0	5n7v	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5N84A	P33981	519	794	857.0	8Q5:60901	Type1	Inactive	DFGin	4.1659	15.4795	ABAminus	-104.85, -26.96	-154.67, 171.21	-114.47, 1.71	301.25, 166.2	82.91, 8.5	out-out	out	11.0769	Saltbr-out	6.3714	HRD-in	-78.13, -54.11	78.05, -3.05	out-out-out	SNCooo	out-out	ActLoopNT-out	11.715	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nooo	APE10-dihe-na	-130.46, 173.28	APE9-dihe-na	98.49, -39.6	APE8-dihe-in	-54.14, 151.84	APE8-rot-out	188.71	APE67-dihe-in	-57.09, -20.86	-123.2, -0.76	APE12-dist-none	999.0	APE11-dist-out	18.8057	APE10-dist-out	13.9014	APE9-dist-out	10.9684	None	None	None	XRAY	2.3	0.207	0.261	A	313.0	253.0	23	30	18	12	[[525, 791]]	1.0	5n84	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5N93A	P33981	519	794	857.0	8QE:60901	Type1	Inactive	DFGin	4.0192	15.1702	ABAminus	-92.51, -36.83	-150.25, 172.26	-115.14, 5.53	287.99, 174.16	76.77, 9.46	out-out	out	10.4196	Saltbr-out	6.3502	HRD-in	-65.77, -53.03	64.47, 9.27	out-out-out	SNCooo	out-out	ActLoopNT-out	11.3803	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnoo	APE10-dihe-na	999.0, 137.01	APE9-dihe-na	-83.24, -158.05	APE8-dihe-in	-135.16, 151.14	APE8-rot-none	999.0	APE67-dihe-in	-70.41, -41.42	-123.42, 2.99	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	20.7717	APE9-dist-out	12.5572	None	TPO686	TPO686	XRAY	2.1	0.218	0.268	A	313.0	257.0	19	30	21	9	[[525, 791]]	1.0	5n93	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5NA0A	P33981	519	794	857.0	8QZ:60901	Type1	Inactive	DFGin	3.9061	14.9376	ABAminus	-90.39, -46.53	-134.15, 168.53	-113.06, 21.64	311.74, 142.6	50.45, 23.25	out-out	out	11.2604	Saltbr-out	7.0665	HRD-in	-75.64, -41.45	54.95, 31.21	out-out-out	SNCooo	out-out	ActLoopNT-out	11.3448	ActLoopCT-out	nonTYR	APEdihe_aaoni	APEdist_nnoo	APE10-dihe-na	999.0, 18.56	APE9-dihe-na	98.71, -54.8	APE8-dihe-out	17.03, 101.78	APE8-rot-none	999.0	APE67-dihe-in	-55.08, -25.7	-88.73, -14.04	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	17.278	APE9-dist-out	11.1515	None	TPO686	TPO686	XRAY	2.9	0.213	0.271	A	313.0	251.0	25	30	18	12	[[525, 791]]	1.0	5na0	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	3HMOA	P33981	514	794	857.0	STU:1	Type1	Inactive	DFGin	4.0338	15.2785	ABAminus	-96.9, -14.35	-154.28, 164.59	-116.14, 11.51	302.21, 156.99	70.91, 11.96	out-out	out	11.1476	Saltbr-out	6.638	HRD-in	-61.3, -53.03	75.35, 1.42	out-out-out	SNCooo	out-out	ActLoopNT-out	11.6803	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnoo	APE10-dihe-na	999.0, -169.39	APE9-dihe-na	94.05, 108.89	APE8-dihe-in	-96.62, 156.5	APE8-rot-out	54.19	APE67-dihe-in	-64.02, -25.79	-101.71, 14.64	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	19.1227	APE9-dist-out	11.5633	None	None	None	XRAY	2.4	0.217	0.261	A	342.0	257.0	24	30	18	12	[[525, 791]]	1.0	3hmo	Homo sapiens	OTHER_TTK_HUMAN	CAMK	1.1e-53	188.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	3HMPA	P33981	516	794	857.0	CX4:1	Type1	Inactive	DFGin	3.9572	15.1018	ABAminus	-86.78, -27.71	-156.64, 169.65	-114.18, 6.72	299.15, 162.64	67.41, 15.29	out-out	out	10.9081	Saltbr-out	5.6134	HRD-in	-69.93, -47.36	72.83, -1.07	out-out-out	SNCooo	out-out	ActLoopNT-out	11.521	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_oooo	APE10-dihe-na	-151.04, 159.23	APE9-dihe-na	115.47, 58.42	APE8-dihe-in	-54.12, 148.09	APE8-rot-out	185.33	APE67-dihe-in	-65.69, -24.89	-99.64, 11.65	APE12-dist-out	22.4555	APE11-dist-out	24.0625	APE10-dist-out	19.1836	APE9-dist-out	11.3824	None	None	None	XRAY	2.3	0.212	0.248	A	342.0	258.0	21	30	20	10	[[525, 791]]	1.0	3hmp	Homo sapiens	OTHER_TTK_HUMAN	CAMK	1.1e-53	188.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5AP3A	P33981	519	794	857.0	AU5:61799	Type1	Inactive	DFGin	3.7649	14.9222	ABAminus	-71.81, -53.86	-135.34, 169.43	-108.89, 4.49	312.31, 146.57	78.37, 4.18	out-out	out	10.8926	Saltbr-out	6.3905	HRD-in	-63.22, -46.84	80.03, -8.42	out-out-out	SNCooo	out-out	ActLoopNT-out	11.6168	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_iooo	APE10-dihe-na	-73.41, 128.83	APE9-dihe-na	68.53, 48.03	APE8-dihe-in	-104.01, 128.39	APE8-rot-none	999.0	APE67-dihe-in	-65.18, -22.8	-106.77, -2.15	APE12-dist-in	13.9565	APE11-dist-out	16.0915	APE10-dist-out	15.0093	APE9-dist-out	10.9961	S611G	TPO686	TPO686	XRAY	2.7	0.192	0.236	A	313.0	251.0	25	30	18	12	[[525, 791]]	1.0	5ap3	Homo sapiens	OTHER_TTK_HUMAN	CAMK	2.2e-53	187.3	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5AP4A	P33981	519	794	857.0	O38:61795	Type1	Inactive	DFGin	3.8933	14.6499	ABAminus	-77.41, -43.92	-141.98, 172.86	-114.54, 10.04	314.02, 147.43	47.66, 52.13	out-out	out	10.6444	Saltbr-out	5.0251	HRD-in	-63.63, -47.01	77.61, -5.77	out-out-out	SNCooo	out-out	ActLoopNT-out	11.4701	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nooo	APE10-dihe-na	-72.43, 107.58	APE9-dihe-na	57.19, 49.68	APE8-dihe-in	-65.83, 162.62	APE8-rot-none	999.0	APE67-dihe-in	-58.82, -25.47	-129.9, -17.39	APE12-dist-none	999.0	APE11-dist-out	16.4862	APE10-dist-out	16.147	APE9-dist-out	10.0398	S611G	TPO686	TPO686	XRAY	2.85	0.198	0.226	A	313.0	254.0	22	30	21	9	[[525, 791]]	1.0	5ap4	Homo sapiens	OTHER_TTK_HUMAN	CAMK	2.2e-53	187.3	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	2ZMDA	P33981	516	795	857.0	537:900	Type1	Inactive	DFGin	3.9529	15.1186	ABAminus	-86.61, -39.79	-132.74, 164.92	-108.9, 8.43	306.24, 151.22	69.07, 16.45	out-out	out	11.2826	Saltbr-out	6.7508	HRD-in	-68.0, -56.19	74.76, 7.11	out-out-out	SNCooo	out-out	ActLoopNT-out	10.4306	ActLoopCT-out	nonTYR	APEdihe_aaoni	APEdist_oooo	APE10-dihe-na	-150.77, 128.69	APE9-dihe-na	166.18, -134.04	APE8-dihe-out	62.78, 28.8	APE8-rot-none	999.0	APE67-dihe-in	-55.23, -33.98	-72.52, -20.32	APE12-dist-out	22.1515	APE11-dist-out	23.3484	APE10-dist-out	19.346	APE9-dist-out	12.2621	T686A	None	None	XRAY	2.88	0.223	0.261	A	390.0	259.0	21	30	21	9	[[525, 791]]	1.0	2zmd	Homo sapiens	OTHER_TTK_HUMAN	CAMK	9e-53	185.2	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	7LQDA	P33981	519	795	857.0	YB4:60901,TOE:60907	Type1,Allosteric	Inactive	DFGin	3.9246	14.3979	ABAminus	-86.7, -42.44	-142.37, 165.69	-105.81, -5.45	307.04, 124.04	74.94, 14.22	out-out	out	10.9537	Saltbr-out	5.9634	HRD-in	-63.64, -55.17	68.93, 10.11	out-out-out	SNCooo	out-out	ActLoopNT-out	10.1553	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_oooo	APE10-dihe-na	-132.63, 166.12	APE9-dihe-na	89.33, 75.78	APE8-dihe-in	-67.85, 152.21	APE8-rot-out	180.89	APE67-dihe-in	-62.72, -28.33	-111.8, 18.01	APE12-dist-out	23.1149	APE11-dist-out	24.2594	APE10-dist-out	18.9066	APE9-dist-out	11.3616	None	None	None	XRAY	1.95	0.2	0.246	A	313.0	265.0	12	30	29	1	[[525, 791]]	1.0	7lqd	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5AP5A	P33981	519	794	857.0	7RO:61795,1KA:61796	Type1,Type1	Inactive	DFGin	3.9362	14.9301	ABAminus	-78.19, -51.66	-127.65, 173.7	-118.82, 17.68	309.34, 138.77	57.34, 35.63	out-out	out	11.1518	Saltbr-out	5.6498	HRD-in	-63.52, -47.29	78.68, -5.43	out-none-out	SNCono	none-out	ActLoopNT-none	999.0	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 112.65	APE8-dihe-in	-71.0, 149.52	APE8-rot-out	187.62	APE67-dihe-in	-58.84, -28.01	-101.03, -8.19	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	10.7748	S611G	None	None	XRAY	2.8	0.205	0.246	A	313.0	248.0	28	30	14	16	[[525, 791]]	1.0	5ap5	Homo sapiens	OTHER_TTK_HUMAN	CAMK	2.2e-53	187.3	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	6TNDA	P33981	516	793	857.0	8RH:901	Type1.5_Back	Inactive	DFGin	3.6505	14.0375	ABAminus	-96.05, -33.83	-151.93, -175.24	-130.65, -1.1	295.33, 131.29	74.45, 12.68	in-in	in	9.5907	Saltbr-in	2.7252	HRD-in	-64.35, -53.45	78.33, -0.67	in-out-out	SNCioo	out-out	ActLoopNT-out	11.0929	ActLoopCT-out	nonTYR	APEdihe_aanoi	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, 162.09	APE8-rot-out	36.86	APE67-dihe-in	-70.08, -16.5	-127.52, 10.48	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.58	0.19	0.249	A	294.0	254.0	24	30	18	12	[[525, 791]]	1.0	6tnd	Homo sapiens	OTHER_TTK_HUMAN	CAMK	6.6e-54	188.9	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	3W1FA	P33981	516	795	857.0	1O5:901	Type1.5_Back	Inactive	DFGin	3.9519	14.4776	ABAminus	-90.62, -43.9	-139.59, 171.72	-118.91, 5.4	303.76, 137.67	67.79, 8.35	in-in	in	9.9038	Saltbr-in	3.2654	HRD-out	-68.15, 103.17	-73.45, -33.92	in-out-out	SNCioo	out-out	ActLoopNT-out	11.8835	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 117.05	APE8-dihe-in	-111.17, 166.66	APE8-rot-out	156.69	APE67-dihe-in	-56.81, -19.1	-120.87, 15.73	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	12.4089	None	None	None	XRAY	2.7	0.237	0.277	A	321.0	259.0	21	30	20	10	[[525, 791]]	1.0	3w1f	Homo sapiens	OTHER_TTK_HUMAN	CAMK	9.1e-54	188.4	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	3WZJA	P33981	516	794	857.0	O43:901	Type1.5_Back	Inactive	DFGin	3.7309	13.6505	ABAminus	-113.7, -33.36	-129.61, 174.06	-121.04, 7.96	308.49, 98.92	65.98, 3.68	in-in	in	9.5066	Saltbr-in	2.9723	HRD-in	-54.5, -49.24	80.42, -18.04	in-out-out	SNCioo	out-out	ActLoopNT-out	11.9175	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 38.01	APE8-dihe-in	-53.44, 162.3	APE8-rot-out	173.78	APE67-dihe-in	-44.25, -39.42	-139.56, 6.8	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	13.1111	None	None	None	XRAY	2.75	0.227	0.282	A	321.0	257.0	22	30	20	10	[[525, 791]]	1.0	3wzj	Homo sapiens	OTHER_TTK_HUMAN	CAMK	9.1e-54	188.4	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	3WZKA	P33981	516	794	857.0	O23:901	Type1.5_Back	Inactive	DFGin	3.9001	14.1238	ABAminus	-105.12, -8.93	-163.2, -176.41	-130.47, 5.31	306.84, 127.56	66.87, 25.4	in-in	in	9.6952	Saltbr-in	3.075	HRD-in	-65.77, -53.52	80.52, -6.31	in-out-out	SNCioo	out-out	ActLoopNT-out	11.9522	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, -152.25	APE8-dihe-in	-163.56, 150.82	APE8-rot-out	169.66	APE67-dihe-in	-62.44, -15.14	-116.23, 12.9	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	12.5051	None	None	None	XRAY	2.3	0.224	0.28	A	321.0	258.0	21	30	20	10	[[525, 791]]	1.0	3wzk	Homo sapiens	OTHER_TTK_HUMAN	CAMK	9.1e-54	188.4	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5NADA	P33981	519	794	857.0	8RH:60901	Type1.5_Back	Inactive	DFGin	3.6777	13.3894	ABAminus	-99.04, -34.18	-143.29, 171.26	-117.88, -6.39	312.7, 119.82	89.46, 5.32	in-in	in	9.5271	Saltbr-in	3.2076	HRD-in	-67.44, -48.54	53.7, 23.12	in-out-none	SNCion	out-none	ActLoopNT-out	11.5082	ActLoopCT-none	nonTYR	APEdihe_aanni	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, 112.82	APE8-rot-none	999.0	APE67-dihe-in	-61.69, -43.53	-106.91, 27.6	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	TPO686	TPO686	XRAY	2.8	0.21	0.29	A	313.0	254.0	22	30	19	11	[[525, 791]]	1.0	5nad	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	6TNBA	P33981	517	794	857.0	8QW:901	Type1.5_Front	Inactive	DFGin	3.8524	15.0944	ABAminus	-120.69, -13.19	-153.82, 168.98	-122.43, 7.93	296.97, 146.25	65.5, 17.91	out-out	out	11.0111	Saltbr-out	8.542	HRD-in	-60.06, -45.03	76.67, -3.67	out-out-out	SNCooo	out-out	ActLoopNT-out	12.1136	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 47.02	APE8-dihe-in	-74.89, 162.5	APE8-rot-none	999.0	APE67-dihe-in	-76.36, -29.64	-145.32, 10.05	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	13.1137	None	TPO686	TPO686	XRAY	2.65	0.215	0.262	A	294.0	252.0	26	30	15	15	[[525, 791]]	1.0	6tnb	Homo sapiens	OTHER_TTK_HUMAN	CAMK	6.6e-54	188.9	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	5N9SA	P33981	519	794	857.0	8QW:60901	Type1.5_Front	Inactive	DFGin	3.8664	14.7964	ABAminus	-103.91, -21.18	-148.36, 167.12	-113.73, -1.29	297.53, 126.79	78.88, 15.58	out-out	out	10.9598	Saltbr-out	9.124	HRD-in	-76.88, -53.0	67.73, 3.84	out-out-out	SNCooo	out-out	ActLoopNT-out	11.8167	ActLoopCT-out	nonTYR	APEdihe_aaini	APEdist_oooo	APE10-dihe-na	176.56, 127.56	APE9-dihe-na	70.2, 2.51	APE8-dihe-in	-61.92, 151.57	APE8-rot-none	999.0	APE67-dihe-in	-61.07, -20.0	-114.51, -10.18	APE12-dist-out	19.5555	APE11-dist-out	17.1912	APE10-dist-out	14.162	APE9-dist-out	10.05	None	TPO686	TPO686	XRAY	2.3	0.194	0.245	A	313.0	257.0	19	30	23	7	[[525, 791]]	1.0	5n9s	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	AF-P33981-K1A	P33981	517	799	857.0	No_ligand	No_ligand	Inactive	DFGin	6.1818	14.6135	BLAminus	-126.46, 171.49	63.49, 76.21	-87.18, 16.05	291.59, 77.39	-58.32, -23.29	in-in	in	8.948	Saltbr-in	2.7779	HRD-in	-72.7, -40.65	66.56, -4.75	in-in-out	SNCiio	in-out	ActLoopNT-in	2.8991	ActLoopCT-out	nonTYR	APEdihe_aaiii	APEdist_iooi	APE10-dihe-na	-105.04, 133.54	APE9-dihe-na	-62.56, -157.84	APE8-dihe-in	-72.75, 119.13	APE8-rot-in	304.88	APE67-dihe-in	-66.58, -15.24	-44.46, -41.66	APE12-dist-in	10.7221	APE11-dist-out	6.3347	APE10-dist-out	9.705	APE9-dist-in	4.0446	None	None	None	AF2	-1.0	1.0	1.0	A	283.0	283.0	0	30	30	0	[[525, 791]]	1.0	AF-P33981-K1	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.7e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	3H9FA	P33981	519	794	857.0	92M:60809	Type1	Inactive	DFGin	4.8308	14.3787	BLAplus	-140.16, 165.23	51.54, 40.51	-99.09, 3.36	73.8, 81.33	-82.43, -174.41	in-none	in	9.9762	Saltbr-none	999.0	HRD-in	-53.0, -59.1	80.34, -10.85	none-out-out	SNCnoo	out-out	ActLoopNT-out	12.1437	ActLoopCT-out	nonTYR	APEdihe_aaoni	APEdist_nnno	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 176.13	APE8-dihe-out	-96.95, -14.8	APE8-rot-none	999.0	APE67-dihe-in	-58.74, -15.24	-121.28, -11.7	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-out	13.615	None	TPO675,TPO676,SEP677	TPO675,TPO676,SEP677	XRAY	2.6	0.21	0.253	A	313.0	259.0	17	30	23	7	[[525, 791]]	1.0	3h9f	Homo sapiens	OTHER_TTK_HUMAN	CAMK	8.3e-54	188.7	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK
TTK	TTK_HUMAN	7CHMA	P33981	516	794	857.0	FZF:801	Type1	Inactive	DFGin	4.4135	14.6083	None	-111.88, -71.82	-63.89, 158.67	-119.5, 9.1	283.45, 179.72	82.92, -15.75	in-in	in	9.5598	Saltbr-in	3.396	HRD-in	-57.59, -51.23	60.31, 6.24	in-out-out	SNCioo	out-out	ActLoopNT-out	12.2637	ActLoopCT-out	nonTYR	APEdihe_aaoni	APEdist_nnoo	APE10-dihe-na	999.0, -62.47	APE9-dihe-na	66.11, 172.68	APE8-dihe-out	-121.28, -175.85	APE8-rot-none	999.0	APE67-dihe-in	-54.56, -33.62	-132.81, 0.36	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-out	19.8631	APE9-dist-out	12.904	None	TPO675,TPO686	TPO675,TPO686	XRAY	2.65	0.212	0.253	A	281.0	260.0	19	30	22	8	[[525, 791]]	1.0	7chm	Homo sapiens	OTHER_TTK_HUMAN	CAMK	5.6e-54	189.1	1.0	256.0	256.0	663	664	665	667	669	553	571	575	644	646	645	647.0	716	693	688	687	686	685	684	683	682	603	Dual specificity protein kinase TTK

OTHER_TTK (Dual specificity protein kinase TTK)

Total number of chains: 0

Active chains: 0

Spatial label	Dihedral label	Number of Chains	Percent	Representative

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Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Species	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name

OTHER_TTK (Dual specificity protein kinase TTK)

Total number of chains: 78

Active chains: 1

Uniprot: TTK_HUMAN

Kinase Domain Residues: 525 - 791

All chains

Representatives

All chains - renumbered by

OTHER_TTK (Dual specificity protein kinase TTK)

Total number of chains: 78

Active chains: 1

All chains

Representatives

All chains - renumbered by

OTHER_TTK (Dual specificity protein kinase TTK)

Total number of chains: 0

Active chains: 0

All chains

Representatives

All chains - renumbered by