STE_MAP4K1 (Mitogen-activated protein kinase kinase kinase kinase 1)

Total number of chains: 104
Active chains: 3
Family: STE
Uniprot: M4K1_HUMAN
Kinase Domain Residues: 17 - 274
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 57 54.8% AF-Q92918-K1A
DFGin None 16 15.4% 9H8FA
DFGout BBAminus 13 12.5% 7M0KA
DFGout None 8 7.7% 9N7RA
DFGinter None 4 3.8% 9BI8A
None None 4 3.8% 6CQEB
DFGin ABAminus 2 1.9% 6NFYB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q92918-K1A 9 282 833.0 No_ligand No_ligand Active DFGin 6.385 14.306 BLAminus -137.99, 179.33 58.7, 63.56 -81.89, 12.08 292.52, 84.97 -57.46, -34.33 in-in in 8.834 Saltbr-in 2.736 HRD-in -83.11, -47.12 66.24, 7.46 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.12, 145.19 APE9-dihe-na 133.94, 175.27 APE8-dihe-in -87.36, 125.88 APE8-rot-in 305.87 APE67-dihe-in -73.49, -21.52 -47.83, -45.86 APE12-dist-in 9.081 APE11-dist-in 12.01 APE10-dist-in 6.194 APE9-dist-in 3.426 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[17, 274]] 1.0 AF-Q92918-K1 STE_MAP4K1_HUMAN STE 1.1e-92 315.9 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
AF-Q92918-K3A 9 282 833.0 No_ligand No_ligand Active DFGin 6.295 13.921 BLAminus -134.67, 173.63 57.41, 70.5 -81.88, 9.86 290.72, 85.76 -58.96, -31.66 in-in in 8.868 Saltbr-in 2.757 HRD-in -78.36, -44.81 68.44, 4.33 in-in-in SNCiii in-in ActLoopNT-in 2.811 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.01, 146.33 APE9-dihe-na 136.5, 166.99 APE8-dihe-in -77.81, 123.18 APE8-rot-in 304.84 APE67-dihe-in -70.02, -28.12 -47.87, -44.31 APE12-dist-in 8.973 APE11-dist-in 11.841 APE10-dist-in 6.158 APE9-dist-in 3.414 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[17, 274]] 1.0 AF-Q92918-K3 STE_MAP4K1_HUMAN STE 1.1e-92 315.9 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
6NFZB 5 292 833.0 B49:9001 Type1 Active DFGin 6.569 14.125 BLAminus -143.42, 177.82 59.84, 65.59 -92.66, 20.58 294.3, 90.38 -59.43, -39.56 in-in in 8.651 Saltbr-in 3.56 HRD-in -78.49, -47.72 65.71, 8.89 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.78, 156.37 APE9-dihe-na 142.37, -174.26 APE8-dihe-in -102.95, 108.5 APE8-rot-in 309.31 APE67-dihe-in -65.17, -28.5 -37.53, -43.95 APE12-dist-in 8.184 APE11-dist-in 11.437 APE10-dist-in 5.975 APE9-dist-in 3.854 None TPO165,SEP171 TPO165,SEP171 XRAY 2.966 0.209 0.251 B 309 277 11 0 0 3 [[17, 274]] 1.0 6nfz STE_MAP4K1_HUMAN STE 1.7e-92 315.3 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
6NFYA 10 292 833.0 B49:69000 Type1 Inactive DFGin 5.593 14.914 ABAminus -77.99, -10.08 -165.37, 178.6 -100.73, 5.46 299.9, 89.52 78.01, -158.47 out-out out 11.415 Saltbr-out 8.806 HRD-in -67.76, -54.16 80.53, -5.66 out-out-out SNCooo out-out ActLoopNT-out 5.972 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -122.43, 132.12 APE9-dihe-na -84.67, -151.78 APE8-dihe-in -82.18, 120.44 APE8-rot-in 317.02 APE67-dihe-in -65.57, -25.36 -45.65, -39.38 APE12-dist-in 12.643 APE11-dist-in 8.454 APE10-dist-out 12.901 APE9-dist-in 3.434 None None None XRAY 2.17 0.194 0.219 A 300 280 3 0 0 0 [[17, 274]] 1.0 6nfy STE_MAP4K1_HUMAN STE 1.6e-92 315.4 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
6NFYB 10 292 833.0 B49:69000 Type1 Inactive DFGin 5.428 14.439 ABAminus -77.59, -12.73 -160.52, 173.22 -94.5, 5.68 304.19, 88.51 70.4, -157.51 out-out out 11.151 Saltbr-out 8.039 HRD-in -66.24, -54.13 78.28, -9.22 out-out-out SNCooo out-out ActLoopNT-out 6.006 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -128.67, 114.08 APE9-dihe-na -99.5, -109.92 APE8-dihe-in -118.15, 107.47 APE8-rot-in 308.81 APE67-dihe-in -64.32, -24.35 -45.36, -36.49 APE12-dist-out 15.067 APE11-dist-in 10.6 APE10-dist-out 15.129 APE9-dist-in 4.289 None None None XRAY 2.17 0.194 0.219 B 300 283 0 0 0 0 [[17, 274]] 1.0 6nfy STE_MAP4K1_HUMAN STE 1.6e-92 315.4 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
6CQDA 2 293 833.0 ANP:60301 ATPlike Inactive DFGin 6.032 13.886 BLAminus -140.97, 178.85 65.6, 83.06 -106.07, 25.72 286.0, 93.85 -58.74, -52.87 in-in in 8.588 Saltbr-in 2.603 HRD-in -75.86, -49.25 70.86, -6.64 in-out-out SNCioo out-out ActLoopNT-out 5.612 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -107.43, -47.34 APE9-dihe-na -128.13, -155.64 APE8-dihe-in -106.29, 135.18 APE8-rot-out 173.28 APE67-dihe-in -57.05, -28.95 -70.03, -34.9 APE12-dist-out 19.71 APE11-dist-out 23.507 APE10-dist-out 22.083 APE9-dist-out 27.312 None None None XRAY 2.12 0.206 0.25 A 297 288 4 0 0 0 [[17, 274]] 1.0 6cqd STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
6CQDB 4 293 833.0 ANP:60302 ATPlike Inactive DFGin 6.101 14.229 BLAminus -144.26, -175.8 58.68, 77.54 -93.97, 33.74 292.79, 90.96 -66.13, -50.88 in-in in 9.463 Saltbr-in 3.209 HRD-in -76.3, -46.87 66.26, 5.48 in-out-out SNCioo out-out ActLoopNT-out 6.073 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.26, 126.5 APE9-dihe-na -81.79, -144.73 APE8-dihe-in -66.65, 145.16 APE8-rot-out 188.81 APE67-dihe-in -66.31, -22.65 -105.18, -2.62 APE12-dist-out 20.763 APE11-dist-out 21.959 APE10-dist-out 21.41 APE9-dist-out 27.357 None None None XRAY 2.12 0.206 0.25 B 297 290 0 0 0 0 [[17, 274]] 1.0 6cqd STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7KACB 7 294 833.0 W9D:401 Type1 Inactive DFGin 6.478 15.039 BLAminus -142.13, 167.59 65.6, 78.09 -86.94, 22.14 297.43, 93.96 -62.14, -40.27 in-out in 9.485 Saltbr-out 4.11 HRD-in -70.49, -51.21 66.78, 6.45 out-out-out SNCooo out-out ActLoopNT-out 6.37 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -130.57, 137.49 APE9-dihe-na -72.47, -120.59 APE8-dihe-in -59.2, 120.08 APE8-rot-out 43.57 APE67-dihe-in -54.01, -32.53 -81.01, -10.52 APE12-dist-out 17.024 APE11-dist-out 21.076 APE10-dist-out 22.501 APE9-dist-out 28.19 L221D,F225E None None XRAY 1.85 0.217 0.232 B 340 288 0 0 0 0 [[17, 274]] 1.0 7kac STE_MAP4K1_HUMAN STE 4.2e-91 310.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7M0MA 2 294 833.0 YK1:301 Type1 Inactive DFGin 6.687 14.597 BLAminus -138.14, 175.74 49.93, 80.08 -88.4, 29.89 288.19, 82.75 -65.83, -47.43 in-in in 8.807 Saltbr-in 2.733 HRD-in -68.9, -51.69 71.01, 3.09 in-out-out SNCioo out-out ActLoopNT-out 6.154 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.06, 129.56 APE9-dihe-na -87.01, -111.4 APE8-dihe-in -115.37, 97.33 APE8-rot-out 42.58 APE67-dihe-in -65.39, -26.85 -90.09, 25.44 APE12-dist-out 19.378 APE11-dist-out 20.699 APE10-dist-out 21.673 APE9-dist-out 28.197 None None None XRAY 1.93 0.188 0.22 A 293 293 0 0 0 0 [[17, 274]] 1.0 7m0m STE_MAP4K1_HUMAN STE 4e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7M0MB 3 293 833.0 YK1:301 Type1 Inactive DFGin 6.499 14.094 BLAminus -136.63, 174.09 57.96, 82.75 -88.09, 24.59 290.28, 84.21 -67.07, -46.88 in-in in 8.776 Saltbr-in 2.746 HRD-in -70.12, -50.67 70.12, 6.36 in-out-out SNCioo out-out ActLoopNT-out 6.168 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -62.85, -31.51 APE9-dihe-na 78.15, -165.12 APE8-dihe-in -72.84, 128.05 APE8-rot-out 198.02 APE67-dihe-in -66.84, -29.23 -96.76, -1.39 APE12-dist-out 19.369 APE11-dist-out 20.336 APE10-dist-out 21.816 APE9-dist-out 27.559 None None None XRAY 1.93 0.188 0.22 B 293 291 0 0 0 0 [[17, 274]] 1.0 7m0m STE_MAP4K1_HUMAN STE 4e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7R9NA 3 293 833.0 F97:301 Type1 Inactive DFGin 6.175 14.585 BLAminus -146.44, -171.42 55.37, 74.43 -87.26, 17.26 286.52, 100.62 -61.54, -42.57 in-in in 9.099 Saltbr-in 2.99 HRD-in -72.69, -47.96 70.45, -0.15 in-out-out SNCioo out-out ActLoopNT-out 6.369 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.78, -25.66 APE9-dihe-na 77.38, -176.25 APE8-dihe-in -64.1, 139.12 APE8-rot-out 194.57 APE67-dihe-in -67.3, -23.81 -101.42, -2.74 APE12-dist-out 19.377 APE11-dist-out 20.863 APE10-dist-out 21.738 APE9-dist-out 27.684 None None None XRAY 1.5 0.167 0.191 A 297 291 0 0 0 0 [[17, 274]] 1.0 7r9n STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7R9NB 4 293 833.0 F97:301 Type1 Inactive DFGin 6.266 15.321 BLAminus -146.02, -177.22 55.93, 75.65 -90.22, 21.38 287.95, 88.23 -62.82, -41.47 in-out in 9.759 Saltbr-out 4.102 HRD-in -72.45, -53.71 75.68, -0.26 out-out-out SNCooo out-out ActLoopNT-out 6.136 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.8, -25.67 APE9-dihe-na 74.93, -177.44 APE8-dihe-in -63.0, 140.67 APE8-rot-out 196.08 APE67-dihe-in -68.28, -21.9 -101.8, -0.97 APE12-dist-out 19.317 APE11-dist-out 20.926 APE10-dist-out 21.759 APE9-dist-out 27.601 None None None XRAY 1.5 0.167 0.191 B 297 286 4 0 0 0 [[17, 274]] 1.0 7r9n STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7R9PA 5 293 833.0 2WI:60301 Type1 Inactive DFGin 5.866 14.838 BLAminus -139.47, 175.09 56.52, 93.83 -96.72, 30.24 292.48, 91.02 -62.77, -53.1 in-out in 9.85 Saltbr-out 3.919 HRD-in -72.5, -57.61 75.96, -1.79 out-out-out SNCooo out-out ActLoopNT-out 6.029 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -97.04, -27.64 APE9-dihe-na 91.61, -154.21 APE8-dihe-in -95.68, 123.06 APE8-rot-out 57.95 APE67-dihe-in -65.56, -28.98 -97.36, 11.82 APE12-dist-out 19.512 APE11-dist-out 20.724 APE10-dist-out 22.086 APE9-dist-out 28.437 None None None XRAY 2.27 0.211 0.232 A 297 286 3 0 0 0 [[17, 274]] 1.0 7r9p STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7R9PB 3 293 833.0 2WI:60301 Type1 Inactive DFGin 5.945 15.276 BLAminus -143.88, 174.79 53.65, 85.57 -90.15, 26.18 296.0, 90.76 -60.23, -48.45 in-out in 9.857 Saltbr-out 4.513 HRD-in -74.84, -52.47 68.69, 9.44 out-out-out SNCooo out-out ActLoopNT-out 6.388 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -80.16, -17.77 APE9-dihe-na 72.14, -120.36 APE8-dihe-in -113.34, 108.55 APE8-rot-out 53.88 APE67-dihe-in -70.0, -20.38 -93.3, 14.58 APE12-dist-out 19.214 APE11-dist-out 21.113 APE10-dist-out 21.907 APE9-dist-out 28.403 None None None XRAY 2.27 0.211 0.232 B 297 291 0 0 0 0 [[17, 274]] 1.0 7r9p STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7R9TA 3 293 833.0 2TR:60301 Type1 Inactive DFGin 6.199 15.021 BLAminus -144.22, 171.46 64.03, 83.98 -91.5, 29.51 294.13, 93.76 -68.67, -43.52 in-out in 9.77 Saltbr-out 4.404 HRD-in -68.79, -58.68 77.22, 3.1 out-out-out SNCooo out-out ActLoopNT-out 6.287 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.84, -26.31 APE9-dihe-na 80.83, -173.28 APE8-dihe-in -66.47, 134.84 APE8-rot-out 189.9 APE67-dihe-in -64.95, -22.68 -106.67, 4.64 APE12-dist-out 19.371 APE11-dist-out 21.086 APE10-dist-out 21.695 APE9-dist-out 27.985 None None None XRAY 2.0 0.2 0.229 A 297 291 0 0 0 0 [[17, 274]] 1.0 7r9t STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7R9TB 4 293 833.0 2TR:60301 Type1 Inactive DFGin 6.036 15.503 BLAminus -141.5, 169.57 67.75, 80.3 -94.86, 21.18 292.6, 84.25 -62.92, -43.96 out-out out 10.104 Saltbr-out 3.908 HRD-in -73.53, -49.63 67.47, 8.97 out-out-out SNCooo out-out ActLoopNT-out 6.186 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -83.95, -20.57 APE9-dihe-na 81.97, -175.21 APE8-dihe-in -65.12, 142.45 APE8-rot-out 187.76 APE67-dihe-in -64.59, -24.46 -107.23, 2.56 APE12-dist-out 19.628 APE11-dist-out 21.091 APE10-dist-out 21.866 APE9-dist-out 27.864 None None None XRAY 2.0 0.2 0.229 B 297 284 6 0 0 0 [[17, 274]] 1.0 7r9t STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9CZTA 5 292 833.0 A1A1E:401 Type1 Inactive DFGin 6.299 14.335 BLAminus -140.35, 175.62 59.71, 82.27 -89.15, 19.04 288.12, 99.31 -55.34, -49.29 in-in in 8.82 Saltbr-in 2.725 HRD-in -72.27, -52.66 66.08, 4.34 in-out-out SNCioo out-out ActLoopNT-out 6.222 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -80.97, -21.01 APE9-dihe-na 79.81, -158.76 APE8-dihe-in -64.23, 143.11 APE8-rot-out 46.29 APE67-dihe-in -61.81, -23.62 -110.28, 1.48 APE12-dist-out 20.711 APE11-dist-out 20.225 APE10-dist-out 20.996 APE9-dist-out 27.52 T165E,S171E None None XRAY 1.69 0.194 0.219 A 309 288 0 0 0 0 [[17, 274]] 1.0 9czt STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9CZTB 5 293 833.0 A1A1E:401 Type1 Inactive DFGin 6.219 14.34 BLAminus -146.07, 172.56 61.38, 80.77 -87.95, 18.12 288.02, 101.14 -55.26, -49.8 in-in in 9.031 Saltbr-in 2.578 HRD-in -76.71, -51.39 71.17, 0.36 in-out-out SNCioo out-out ActLoopNT-out 6.295 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.79, -16.26 APE9-dihe-na 71.23, -149.72 APE8-dihe-in -63.45, 121.67 APE8-rot-out 72.41 APE67-dihe-in -58.64, -26.17 -98.87, 3.1 APE12-dist-out 20.187 APE11-dist-out 20.45 APE10-dist-out 21.646 APE9-dist-out 28.253 T165E,S171E None None XRAY 1.69 0.194 0.219 B 309 289 0 0 0 0 [[17, 274]] 1.0 9czt STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9CZUA 5 293 833.0 A1A1D:402 Type1 Inactive DFGin 6.489 14.351 BLAminus -137.75, 175.2 60.15, 86.19 -93.64, 18.19 290.54, 89.04 -56.44, -52.47 in-in in 9.037 Saltbr-in 2.728 HRD-in -75.08, -47.99 65.32, -1.97 in-out-out SNCioo out-out ActLoopNT-out 6.362 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.17, -48.47 APE9-dihe-na 84.19, -157.27 APE8-dihe-in -72.64, 141.86 APE8-rot-out 43.34 APE67-dihe-in -57.98, -25.96 -98.31, -2.0 APE12-dist-out 20.226 APE11-dist-out 21.215 APE10-dist-out 21.689 APE9-dist-out 27.932 T165E,S171E None None XRAY 1.85 0.198 0.248 A 309 289 0 0 0 0 [[17, 274]] 1.0 9czu STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9CZUB 5 293 833.0 A1A1D:401 Type1 Inactive DFGin 6.627 14.256 BLAminus -142.58, 175.68 62.6, 83.65 -94.25, 18.74 283.17, 98.7 -57.67, -46.92 in-in in 8.941 Saltbr-in 2.711 HRD-in -79.54, -50.09 64.64, 8.44 in-out-out SNCioo out-out ActLoopNT-out 6.227 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -43.64, -23.49 APE9-dihe-na -83.63, -155.02 APE8-dihe-in -111.85, 117.82 APE8-rot-out 188.67 APE67-dihe-in -63.02, -29.49 -59.84, -30.8 APE12-dist-none 999.0 APE11-dist-out 21.237 APE10-dist-out 22.531 APE9-dist-out 27.303 T165E,S171E None None XRAY 1.85 0.198 0.248 B 309 281 8 0 0 3 [[17, 274]] 1.0 9czu STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9CZUC 2 293 833.0 A1A1D:401 Type1 Inactive DFGin 6.442 14.095 BLAminus -139.71, -179.22 60.34, 85.98 -94.91, 23.99 287.04, 94.1 -63.75, -52.11 in-in in 8.778 Saltbr-in 2.819 HRD-in -74.72, -51.25 65.43, 3.35 in-out-out SNCioo out-out ActLoopNT-out 6.098 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.95, -44.47 APE9-dihe-na 71.68, -170.18 APE8-dihe-in -74.3, 141.89 APE8-rot-out 51.45 APE67-dihe-in -58.88, -33.48 -102.84, 6.18 APE12-dist-out 19.796 APE11-dist-out 21.474 APE10-dist-out 22.33 APE9-dist-out 28.448 T165E,S171E None None XRAY 1.85 0.198 0.248 C 309 287 5 0 0 0 [[17, 274]] 1.0 9czu STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9CZUD 8 293 833.0 A1A1D:401 Type1 Inactive DFGin 6.537 14.124 BLAminus -133.54, 178.66 62.04, 84.09 -97.33, 23.34 283.9, 99.03 -63.9, -49.28 in-in in 8.641 Saltbr-in 2.812 HRD-in -74.93, -53.89 72.23, 2.08 in-out-out SNCioo out-out ActLoopNT-out 6.125 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -62.67, -39.85 APE9-dihe-na 75.44, -164.27 APE8-dihe-in -73.76, 140.22 APE8-rot-out 49.21 APE67-dihe-in -59.67, -27.82 -103.43, 3.8 APE12-dist-out 19.334 APE11-dist-out 20.71 APE10-dist-out 22.031 APE9-dist-out 28.546 T165E,S171E None None XRAY 1.85 0.198 0.248 D 309 282 4 0 0 0 [[17, 274]] 1.0 9czu STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9CZWA 5 292 833.0 A1A1C:401 Type1 Inactive DFGin 6.484 14.447 BLAminus -142.4, 176.37 61.0, 83.2 -91.86, 20.12 285.36, 100.06 -58.94, -45.03 in-in in 8.966 Saltbr-in 2.722 HRD-in -79.51, -49.76 66.53, 5.58 in-out-out SNCioo out-out ActLoopNT-out 6.181 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -76.64, -6.98 APE9-dihe-na 106.64, 178.38 APE8-dihe-in -78.01, 124.7 APE8-rot-in 294.47 APE67-dihe-in -59.5, -32.1 -67.37, -27.03 APE12-dist-out 21.065 APE11-dist-out 20.811 APE10-dist-out 20.554 APE9-dist-out 27.132 T165E,S171E None None XRAY 1.59 0.191 0.221 A 309 288 0 0 0 0 [[17, 274]] 1.0 9czw STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9CZWB 5 293 833.0 A1A1C:401 Type1 Inactive DFGin 6.281 14.195 BLAminus -145.03, 174.12 65.2, 80.3 -86.34, 20.99 291.56, 97.25 -57.8, -48.9 in-in in 9.065 Saltbr-in 2.581 HRD-in -78.76, -55.32 70.65, 5.05 in-out-out SNCioo out-out ActLoopNT-out 6.137 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.11, -8.45 APE9-dihe-na 103.65, 171.84 APE8-dihe-in -56.95, 141.18 APE8-rot-out 40.62 APE67-dihe-in -59.63, -31.73 -86.68, -21.16 APE12-dist-out 21.34 APE11-dist-out 20.851 APE10-dist-out 20.86 APE9-dist-out 27.494 T165E,S171E None None XRAY 1.59 0.191 0.221 B 309 289 0 0 0 0 [[17, 274]] 1.0 9czw STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9CZXA 1 292 833.0 A1A1B:60401 Type1 Inactive DFGin 5.456 14.116 BLAminus -136.88, 170.25 74.65, 86.4 -97.31, 23.38 288.29, 110.97 -60.88, -50.46 in-in in 9.02 Saltbr-in 2.721 HRD-in -77.07, -55.67 66.53, 5.39 in-out-out SNCioo out-out ActLoopNT-out 6.178 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.91, -29.12 APE9-dihe-na 72.57, -159.77 APE8-dihe-in -67.35, 141.44 APE8-rot-out 207.67 APE67-dihe-in -52.4, -31.07 -100.58, -15.44 APE12-dist-out 20.226 APE11-dist-out 20.5 APE10-dist-out 21.294 APE9-dist-out 27.598 T165E,S171E None None XRAY 1.464 0.216 0.242 A 309 288 4 0 0 0 [[17, 274]] 1.0 9czx STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9D00A 6 293 833.0 A1A1A:901 Type1 Inactive DFGin 6.336 14.447 BLAminus -140.17, 169.69 66.05, 82.16 -90.41, 19.67 289.69, 94.63 -57.9, -45.24 in-in in 9.147 Saltbr-in 2.544 HRD-in -69.4, -52.71 68.37, -0.38 in-out-out SNCioo out-out ActLoopNT-out 6.239 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -115.73, -16.53 APE9-dihe-na 70.33, -148.11 APE8-dihe-in -67.12, 125.31 APE8-rot-out 58.95 APE67-dihe-in -62.24, -23.42 -101.84, 10.31 APE12-dist-out 19.399 APE11-dist-out 20.636 APE10-dist-out 21.399 APE9-dist-out 28.194 None None None XRAY 1.951 0.247 0.279 A 309 284 4 0 0 0 [[17, 274]] 1.0 9d00 STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9D00B 4 292 833.0 A1A1A:401 Type1 Inactive DFGin 6.336 14.317 BLAminus -139.86, 169.35 66.73, 83.9 -91.21, 18.67 290.65, 95.0 -58.22, -46.78 in-in in 9.18 Saltbr-in 2.544 HRD-in -69.48, -53.11 69.59, -1.41 in-out-out SNCioo out-out ActLoopNT-out 6.19 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.7, -18.52 APE9-dihe-na 69.55, -149.8 APE8-dihe-in -76.21, 127.76 APE8-rot-out 54.96 APE67-dihe-in -61.76, -27.13 -102.55, 9.59 APE12-dist-out 19.308 APE11-dist-out 20.505 APE10-dist-out 21.513 APE9-dist-out 28.174 None None None XRAY 1.951 0.247 0.279 B 309 284 5 0 0 0 [[17, 274]] 1.0 9d00 STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9D00C 4 293 833.0 A1A1A:401 Type1 Inactive DFGin 6.242 14.447 BLAminus -140.24, 170.38 65.3, 82.76 -91.49, 20.02 291.46, 93.21 -59.78, -44.19 in-in in 9.119 Saltbr-in 2.57 HRD-in -70.48, -52.81 68.16, -0.69 in-out-out SNCioo out-out ActLoopNT-out 6.199 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -95.51, -17.94 APE9-dihe-na 66.33, -149.39 APE8-dihe-in -68.18, 126.44 APE8-rot-out 60.28 APE67-dihe-in -61.75, -26.6 -102.65, 9.42 APE12-dist-out 19.711 APE11-dist-out 20.098 APE10-dist-out 21.274 APE9-dist-out 28.024 None None None XRAY 1.951 0.247 0.279 C 309 284 6 0 0 0 [[17, 274]] 1.0 9d00 STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9D00D 4 292 833.0 A1A1A:401 Type1 Inactive DFGin 6.342 14.371 BLAminus -139.3, 170.77 65.41, 83.56 -92.51, 20.91 290.0, 94.21 -58.73, -44.95 in-in in 9.15 Saltbr-in 2.682 HRD-in -70.53, -51.9 66.76, -0.27 in-out-out SNCioo out-out ActLoopNT-out 6.168 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -82.51, -20.77 APE9-dihe-na 70.59, -152.77 APE8-dihe-in -74.62, 128.96 APE8-rot-out 53.71 APE67-dihe-in -61.19, -25.01 -101.63, 7.98 APE12-dist-out 19.416 APE11-dist-out 20.746 APE10-dist-out 21.537 APE9-dist-out 28.314 None None None XRAY 1.951 0.247 0.279 D 309 285 4 0 0 0 [[17, 274]] 1.0 9d00 STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9BIKB 4 293 833.0 A1APO:60306 Type1 Inactive DFGin 5.683 14.357 BLAminus -141.88, 171.96 69.55, 86.63 -96.36, 19.05 290.17, 117.22 -60.62, -46.28 in-out in 9.456 Saltbr-out 3.849 HRD-in -71.2, -54.39 71.44, 3.91 out-out-out SNCooo out-out ActLoopNT-out 6.194 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -83.12, -39.97 APE9-dihe-na 75.35, -114.91 APE8-dihe-in -113.34, 93.34 APE8-rot-out 58.64 APE67-dihe-in -71.32, -21.13 -98.03, 27.22 APE12-dist-out 20.218 APE11-dist-out 19.938 APE10-dist-out 22.034 APE9-dist-out 28.365 None None None XRAY 2.25 0.199 0.244 B 311 288 2 0 0 0 [[17, 274]] 1.0 9bik STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9BJ1A 3 293 833.0 A1APR:60307 Type1 Inactive DFGin 6.569 14.529 BLAminus -146.0, -178.93 54.39, 80.26 -93.68, 26.78 292.39, 86.08 -69.21, -46.11 in-out in 9.572 Saltbr-out 5.495 HRD-in -81.77, -51.32 67.22, 6.16 out-out-out SNCooo out-out ActLoopNT-out 5.941 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.59, -26.74 APE9-dihe-na 73.54, -133.9 APE8-dihe-in -118.37, 92.73 APE8-rot-out 36.98 APE67-dihe-in -71.33, -19.35 -88.26, 22.61 APE12-dist-out 19.485 APE11-dist-out 20.488 APE10-dist-out 22.052 APE9-dist-out 28.312 None None None XRAY 2.18 0.176 0.228 A 311 291 0 0 0 0 [[17, 274]] 1.0 9bj1 STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9NACA 3 293 833.0 A1BWM:60306 Type1 Inactive DFGin 6.288 14.967 BLAminus -143.28, -179.9 57.0, 78.75 -89.28, 19.43 296.28, 96.63 -61.6, -43.89 in-out in 9.294 Saltbr-out 3.664 HRD-in -70.18, -52.47 72.86, -0.69 out-out-out SNCooo out-out ActLoopNT-out 6.143 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -62.56, -29.04 APE9-dihe-na 78.31, -171.8 APE8-dihe-in -65.01, 137.86 APE8-rot-out 193.85 APE67-dihe-in -68.58, -21.98 -102.03, 0.3 APE12-dist-out 19.421 APE11-dist-out 20.936 APE10-dist-out 21.655 APE9-dist-out 27.942 None None None XRAY 1.45 0.178 0.193 A 311 291 0 0 0 0 [[17, 274]] 1.0 9nac STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9NACB 5 293 833.0 A1BWM:60312 Type1 Inactive DFGin 6.317 14.872 BLAminus -141.68, 174.58 62.05, 80.76 -88.85, 23.58 293.45, 94.02 -62.42, -47.37 in-out in 9.662 Saltbr-out 4.157 HRD-in -72.47, -48.21 72.81, -1.94 out-out-out SNCooo out-out ActLoopNT-out 6.322 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.0 APE8-rot-out 87.18 APE67-dihe-in -67.23, -23.72 -101.81, -5.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.45 0.178 0.193 B 311 285 4 0 0 4 [[17, 274]] 1.0 9nac STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9NBSA 3 293 833.0 A1BW4:312 Type1 Inactive DFGin 6.543 15.139 BLAminus -146.1, 166.61 69.7, 85.0 -90.14, 23.76 293.67, 93.84 -61.08, -43.36 out-out out 10.091 Saltbr-out 4.649 HRD-in -75.52, -51.94 71.79, 2.7 out-out-out SNCooo out-out ActLoopNT-out 6.275 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -64.95, -30.13 APE9-dihe-na 83.5, -176.39 APE8-dihe-in -60.89, 134.02 APE8-rot-out 196.75 APE67-dihe-in -67.54, -23.89 -100.39, -0.26 APE12-dist-out 19.234 APE11-dist-out 20.805 APE10-dist-out 21.589 APE9-dist-out 27.824 None None None XRAY 1.8 0.167 0.207 A 311 291 0 0 0 0 [[17, 274]] 1.0 9nbs STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9NBSB 4 293 833.0 A1BW4:309 Type1 Inactive DFGin 6.679 15.424 BLAminus -142.94, 164.96 71.95, 83.55 -93.82, 22.6 293.89, 95.45 -62.36, -42.17 out-out out 10.076 Saltbr-out 3.712 HRD-in -71.82, -53.88 74.04, 5.26 out-out-out SNCooo out-out ActLoopNT-out 6.126 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.84, -27.25 APE9-dihe-na 80.94, -173.11 APE8-dihe-in -65.61, 141.02 APE8-rot-out 195.95 APE67-dihe-in -67.9, -21.76 -102.86, -1.4 APE12-dist-out 19.216 APE11-dist-out 20.977 APE10-dist-out 21.623 APE9-dist-out 27.685 None None None XRAY 1.8 0.167 0.207 B 311 290 0 0 0 0 [[17, 274]] 1.0 9nbs STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9NC2A 3 292 833.0 F97:301 Type1 Inactive DFGin 6.169 14.56 BLAminus -146.03, -172.66 54.61, 75.11 -87.07, 18.0 287.4, 99.86 -60.8, -42.16 in-in in 9.077 Saltbr-in 3.084 HRD-in -71.62, -49.35 69.24, 2.43 in-out-out SNCioo out-out ActLoopNT-out 6.365 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.88, -25.86 APE9-dihe-na 79.92, -176.93 APE8-dihe-in -63.28, 137.33 APE8-rot-out 195.9 APE67-dihe-in -69.31, -23.4 -99.38, -2.77 APE12-dist-out 19.365 APE11-dist-out 20.869 APE10-dist-out 21.697 APE9-dist-out 27.663 T165E,S171E None None XRAY 1.5 0.159 0.182 A 311 290 0 0 0 0 [[17, 274]] 1.0 9nc2 STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9NC2B 4 293 833.0 F97:301 Type1 Inactive DFGin 6.219 15.322 BLAminus -146.56, -178.89 56.97, 76.11 -90.84, 22.27 287.71, 91.06 -63.05, -41.66 in-out in 9.74 Saltbr-out 4.08 HRD-in -71.95, -49.68 67.73, 5.0 out-out-out SNCooo out-out ActLoopNT-out 6.107 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -65.85, -26.59 APE9-dihe-na 76.68, -178.01 APE8-dihe-in -63.02, 140.61 APE8-rot-out 197.6 APE67-dihe-in -68.97, -20.58 -101.56, -1.68 APE12-dist-out 19.288 APE11-dist-out 20.819 APE10-dist-out 21.719 APE9-dist-out 27.484 T165E,S171E None None XRAY 1.5 0.159 0.182 B 311 283 7 0 0 0 [[17, 274]] 1.0 9nc2 STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8FH4A 4 293 833.0 XXF:60401 Type1 Inactive DFGin 6.846 14.475 BLAminus -131.99, 171.23 62.34, 86.7 -92.12, 20.1 289.3, 88.42 -59.7, -48.05 in-in in 9.232 Saltbr-in 2.734 HRD-in -67.47, -51.18 67.4, 4.94 in-out-out SNCioo out-out ActLoopNT-out 6.199 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.65, -44.57 APE9-dihe-na 76.29, -171.23 APE8-dihe-in -62.48, 141.12 APE8-rot-out 34.25 APE67-dihe-in -59.58, -27.68 -102.29, 0.49 APE12-dist-out 20.304 APE11-dist-out 21.079 APE10-dist-out 21.421 APE9-dist-out 27.259 T165E,S171E None None XRAY 1.827 0.189 0.215 A 331 290 0 0 0 0 [[17, 274]] 1.0 8fh4 STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8FH4B 6 302 833.0 XXF:60402 Type1 Inactive DFGin 6.551 14.294 BLAminus -141.43, 174.43 62.64, 85.33 -93.2, 13.55 285.99, 85.49 -57.34, -45.75 in-in in 8.939 Saltbr-in 2.697 HRD-in -67.85, -50.88 67.73, 2.48 in-out-out SNCioo out-out ActLoopNT-out 6.309 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.39, -32.57 APE9-dihe-na 75.42, -167.37 APE8-dihe-in -61.44, 126.8 APE8-rot-out 59.49 APE67-dihe-in -56.24, -30.95 -97.05, -0.91 APE12-dist-out 19.464 APE11-dist-out 20.586 APE10-dist-out 21.665 APE9-dist-out 28.047 T165E,S171E None None XRAY 1.827 0.189 0.215 B 331 297 0 0 0 0 [[17, 274]] 1.0 8fh4 STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8FH4C 1 292 833.0 XXF:60401 Type1 Inactive DFGin 6.824 14.118 BLAminus -136.31, 172.65 64.01, 85.1 -95.02, 19.77 288.84, 83.7 -61.21, -46.39 in-in in 8.967 Saltbr-in 2.733 HRD-in -69.91, -50.19 67.9, 0.86 in-out-out SNCioo out-out ActLoopNT-out 6.08 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.7, -68.85 APE9-dihe-na -109.26, -27.15 APE8-dihe-in -115.11, 101.44 APE8-rot-out 62.11 APE67-dihe-in -65.51, -20.35 -96.81, 16.0 APE12-dist-out 19.318 APE11-dist-out 20.935 APE10-dist-out 23.085 APE9-dist-out 28.365 T165E,S171E None None XRAY 1.827 0.189 0.215 C 331 292 0 0 0 0 [[17, 274]] 1.0 8fh4 STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8FH4D 8 292 833.0 XXF:60401 Type1 Inactive DFGin 6.646 14.023 BLAminus -135.73, 170.9 66.66, 83.46 -93.58, 25.1 289.61, 94.72 -69.05, -41.66 in-in in 9.022 Saltbr-in 2.745 HRD-in -74.6, -51.27 71.89, -5.96 in-out-out SNCioo out-out ActLoopNT-out 6.134 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.02 APE8-dihe-in -67.05, 131.5 APE8-rot-out 192.16 APE67-dihe-in -57.98, -30.82 -102.78, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 27.427 T165E,S171E None None XRAY 1.827 0.189 0.215 D 331 276 9 0 0 4 [[17, 274]] 1.0 8fh4 STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8FJZA 3 292 833.0 Y3I:401 Type1 Inactive DFGin 6.51 14.504 BLAminus -137.7, 170.08 62.89, 84.84 -92.48, 16.46 289.48, 97.05 -57.69, -48.7 in-in in 9.024 Saltbr-in 2.853 HRD-in -76.6, -50.02 65.48, 5.07 in-out-out SNCioo out-out ActLoopNT-out 6.147 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.77, -28.54 APE9-dihe-na 83.8, -160.52 APE8-dihe-in -69.85, 130.12 APE8-rot-out 203.17 APE67-dihe-in -57.6, -27.08 -102.15, -1.9 APE12-dist-out 19.688 APE11-dist-out 20.668 APE10-dist-out 21.671 APE9-dist-out 28.13 T165E,S171E None None XRAY 1.897 0.216 0.249 A 331 288 2 0 0 0 [[17, 274]] 1.0 8fjz STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8FJZB 5 292 833.0 Y3I:401 Type1 Inactive DFGin 6.57 14.021 BLAminus -137.02, 169.84 67.81, 83.93 -94.03, 22.71 289.99, 87.03 -64.87, -48.53 in-in in 8.905 Saltbr-in 2.675 HRD-in -75.0, -51.65 69.43, 3.22 in-out-out SNCioo out-out ActLoopNT-out 5.948 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 126.69 APE8-rot-out 63.83 APE67-dihe-in -54.59, -38.97 -101.21, 8.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T165E,S171E None None XRAY 1.897 0.216 0.249 B 331 284 4 0 0 4 [[17, 274]] 1.0 8fjz STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8FJZC 5 292 833.0 Y3I:401 Type1 Inactive DFGin 6.587 14.237 BLAminus -130.95, 168.73 65.84, 84.49 -90.64, 23.57 288.05, 96.05 -64.63, -46.84 in-in in 8.898 Saltbr-in 2.7 HRD-in -82.44, -52.09 67.55, 1.71 in-out-out SNCioo out-out ActLoopNT-out 6.231 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -63.71, -26.25 APE9-dihe-na 76.16, -172.12 APE8-dihe-in -60.33, 130.84 APE8-rot-out 195.91 APE67-dihe-in -63.98, -25.54 -102.76, 2.25 APE12-dist-out 19.401 APE11-dist-out 20.592 APE10-dist-out 21.738 APE9-dist-out 28.12 T165E,S171E None None XRAY 1.897 0.216 0.249 C 331 288 0 0 0 0 [[17, 274]] 1.0 8fjz STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8FJZD 5 292 833.0 Y3I:401 Type1 Inactive DFGin 6.717 14.041 BLAminus -137.08, 171.73 59.36, 82.37 -86.27, 18.66 292.08, 95.93 -58.09, -54.94 in-in in 8.988 Saltbr-in 2.732 HRD-in -69.09, -53.22 71.65, -0.73 in-out-out SNCioo out-out ActLoopNT-out 6.095 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -148.42 APE8-dihe-in -68.43, 138.08 APE8-rot-out 39.71 APE67-dihe-in -52.93, -33.25 -97.78, -5.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.327 T165E,S171E None None XRAY 1.897 0.216 0.249 D 331 279 9 0 0 5 [[17, 274]] 1.0 8fjz STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8FJZE 6 292 833.0 Y3I:401 Type1 Inactive DFGin 6.774 14.099 BLAminus -136.75, 169.37 68.25, 86.68 -95.74, 24.36 294.3, 85.62 -65.14, -47.45 in-in in 8.919 Saltbr-in 2.724 HRD-in -74.26, -49.77 67.78, 3.39 in-out-out SNCioo out-out ActLoopNT-out 6.066 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -56.26, -48.49 APE9-dihe-na 80.16, 179.63 APE8-dihe-in -54.87, 130.2 APE8-rot-in 306.01 APE67-dihe-in -57.58, -32.37 -99.48, -10.41 APE12-dist-out 19.306 APE11-dist-out 20.62 APE10-dist-out 22.177 APE9-dist-out 28.139 T165E,S171E None None XRAY 1.897 0.216 0.249 E 331 283 4 0 0 0 [[17, 274]] 1.0 8fjz STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8FJZF 9 292 833.0 Y3I:401 Type1 Inactive DFGin 6.754 14.514 BLAminus -131.7, 172.77 61.74, 84.47 -90.86, 22.68 286.38, 91.5 -60.13, -49.97 in-in in 9.121 Saltbr-in 2.741 HRD-in -74.14, -51.77 66.66, 4.96 in-out-out SNCioo out-out ActLoopNT-out 5.986 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -63.64, -30.73 APE9-dihe-na 73.64, -165.36 APE8-dihe-in -58.14, 130.21 APE8-rot-out 197.86 APE67-dihe-in -59.67, -30.33 -96.67, -2.31 APE12-dist-out 19.267 APE11-dist-out 20.726 APE10-dist-out 21.359 APE9-dist-out 27.978 T165E,S171E None None XRAY 1.897 0.216 0.249 F 331 276 8 0 0 0 [[17, 274]] 1.0 8fjz STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8FKOA 4 292 833.0 Y3O:401 Type1 Inactive DFGin 6.6 14.474 BLAminus -136.74, 175.6 60.99, 80.38 -90.69, 19.24 290.65, 92.45 -58.8, -50.56 in-in in 9.008 Saltbr-in 2.865 HRD-in -73.32, -49.99 68.3, 0.65 in-out-out SNCioo out-out ActLoopNT-out 6.173 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -69.21, -28.97 APE9-dihe-na 81.7, -165.26 APE8-dihe-in -68.43, 130.79 APE8-rot-out 206.57 APE67-dihe-in -61.7, -26.02 -104.74, 4.48 APE12-dist-out 19.399 APE11-dist-out 20.778 APE10-dist-out 21.72 APE9-dist-out 28.14 T165E,S171E None None XRAY 2.104 0.222 0.258 A 331 289 0 0 0 0 [[17, 274]] 1.0 8fko STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8FKOB 5 292 833.0 Y3O:401 Type1 Inactive DFGin 6.742 14.362 BLAminus -132.05, 170.07 64.75, 88.13 -97.12, 25.5 288.76, 98.36 -61.57, -55.4 in-in in 9.414 Saltbr-in 2.741 HRD-in -70.11, -54.58 72.79, -2.56 in-out-out SNCioo out-out ActLoopNT-out 5.828 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 135.87 APE8-rot-out 50.22 APE67-dihe-in -58.48, -31.01 -101.42, 4.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T165E,S171E None None XRAY 2.104 0.222 0.258 B 331 281 7 0 0 7 [[17, 274]] 1.0 8fko STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8FKOC 5 292 833.0 Y3O:401 Type1 Inactive DFGin 6.775 14.419 BLAminus -132.55, 171.23 64.29, 81.94 -88.9, 26.84 288.08, 99.44 -65.27, -52.46 in-in in 8.665 Saltbr-in 2.911 HRD-in -74.45, -54.73 70.38, 2.95 in-out-out SNCioo out-out ActLoopNT-out 6.228 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.61, -32.11 APE9-dihe-na 79.88, -174.37 APE8-dihe-in -60.81, 133.78 APE8-rot-out 52.53 APE67-dihe-in -64.71, -25.08 -101.63, 4.73 APE12-dist-out 19.479 APE11-dist-out 20.54 APE10-dist-out 21.92 APE9-dist-out 28.333 T165E,S171E None None XRAY 2.104 0.222 0.258 C 331 288 0 0 0 0 [[17, 274]] 1.0 8fko STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8FKOD 5 292 833.0 Y3O:401 Type1 Inactive DFGin 6.709 14.678 BLAminus -131.09, 178.78 56.35, 80.98 -89.1, 26.55 286.22, 90.67 -64.13, -49.82 in-in in 8.965 Saltbr-in 2.747 HRD-in -66.34, -52.49 71.26, -7.01 in-out-out SNCioo out-out ActLoopNT-out 6.206 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -158.42 APE8-dihe-in -63.3, 145.09 APE8-rot-out 69.9 APE67-dihe-in -64.17, -28.12 -107.51, 10.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.25 T165E,S171E None None XRAY 2.104 0.222 0.258 D 331 279 9 0 0 5 [[17, 274]] 1.0 8fko STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8FKOE 9 292 833.0 Y3O:401 Type1 Inactive DFGin 6.435 14.085 BLAminus -135.28, 164.55 67.79, 89.79 -102.78, 38.26 298.04, 85.81 -76.64, -45.96 in-in in 8.677 Saltbr-in 2.736 HRD-in -62.44, -55.25 72.64, 2.07 in-out-out SNCioo out-out ActLoopNT-out 6.141 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -58.79, -42.45 APE9-dihe-na 75.19, -172.93 APE8-dihe-in -61.39, 128.93 APE8-rot-in 302.43 APE67-dihe-in -54.75, -33.19 -95.27, -10.5 APE12-dist-out 19.343 APE11-dist-out 20.455 APE10-dist-out 21.955 APE9-dist-out 28.115 T165E,S171E None None XRAY 2.104 0.222 0.258 E 331 271 13 0 0 0 [[17, 274]] 1.0 8fko STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7L24A 7 293 833.0 XHV:301 Type1 Inactive DFGin 7.009 14.62 BLAminus -143.84, -179.7 61.55, 69.1 -91.94, 12.61 283.35, 87.89 -58.65, -41.1 in-in in 8.865 Saltbr-in 3.018 HRD-in -76.34, -55.95 67.89, 13.07 in-out-out SNCioo out-out ActLoopNT-out 6.039 ActLoopCT-out nonTYR APEdihe_aannn APEdist_onnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -83.54, -38.3 999.0, -31.75 APE12-dist-out 21.759 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S171A,G191C None None XRAY 2.68 0.227 0.272 A 288 283 4 0 0 4 [[17, 274]] 1.0 7l24 STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7L24B 7 293 833.0 XHV:301 Type1 Inactive DFGin 6.546 13.975 BLAminus -135.14, 169.97 71.4, 79.39 -97.76, 12.38 287.4, 86.62 -58.33, -41.41 in-in in 8.914 Saltbr-in 2.438 HRD-in -76.97, -54.35 69.63, 6.66 in-out-out SNCioo out-out ActLoopNT-out 5.569 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 128.53 APE9-dihe-na -79.83, -176.62 APE8-dihe-in -81.98, 123.97 APE8-rot-in 295.15 APE67-dihe-in -69.95, -26.85 -67.53, -22.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 22.945 APE9-dist-out 27.304 S171A,G191C None None XRAY 2.68 0.227 0.272 B 288 271 16 0 0 11 [[17, 274]] 1.0 7l24 STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7L24C 8 293 833.0 XHV:301 Type1 Inactive DFGin 6.624 13.96 BLAminus -136.48, 171.4 72.39, 79.87 -99.38, 13.47 287.36, 81.53 -59.93, -44.55 in-in in 9.034 Saltbr-in 3.127 HRD-in -75.35, -55.81 67.71, 14.86 in-out-out SNCioo out-out ActLoopNT-out 5.741 ActLoopCT-out nonTYR APEdihe_aanii APEdist_ooon APE10-dihe-na -156.45, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 105.18 APE8-rot-in 294.61 APE67-dihe-in -70.16, -27.48 -121.22, 17.23 APE12-dist-out 19.985 APE11-dist-out 20.145 APE10-dist-out 21.577 APE9-dist-none 999.0 S171A,G191C None None XRAY 2.68 0.227 0.272 C 288 283 3 0 0 3 [[17, 274]] 1.0 7l24 STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7L24D 8 292 833.0 XHV:301 Type1 Inactive DFGin 6.968 14.326 BLAminus -134.37, 175.58 63.92, 76.15 -95.35, 10.89 286.09, 85.69 -58.43, -42.03 in-in in 8.952 Saltbr-in 3.364 HRD-in -77.33, -58.31 72.58, 6.78 in-out-out SNCioo out-out ActLoopNT-out 5.813 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -101.26, -46.51 APE9-dihe-na 81.9, 171.61 APE8-dihe-in -50.17, 142.46 APE8-rot-out 55.63 APE67-dihe-in -69.03, -27.01 -120.49, 22.45 APE12-dist-out 19.237 APE11-dist-out 21.048 APE10-dist-out 21.272 APE9-dist-out 27.624 S171A,G191C None None XRAY 2.68 0.227 0.272 D 288 274 11 0 0 0 [[17, 274]] 1.0 7l24 STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9CZXB 8 292 833.0 A1A1B:60402,A1A1B:60403 Type1,Allosteric Inactive DFGin 6.343 14.279 BLAminus -134.7, 170.43 71.89, 82.48 -96.36, 23.25 289.39, 99.86 -63.19, -37.33 in-in in 9.036 Saltbr-in 2.712 HRD-in -68.81, -50.24 70.2, 0.87 in-out-out SNCioo out-out ActLoopNT-out 5.927 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.69, 123.51 APE9-dihe-na -83.33, -140.23 APE8-dihe-in -74.52, 137.21 APE8-rot-out 68.09 APE67-dihe-in -59.39, -33.85 -97.6, 2.5 APE12-dist-out 20.309 APE11-dist-out 20.831 APE10-dist-out 22.527 APE9-dist-out 28.487 T165E,S171E None None XRAY 1.464 0.216 0.242 B 309 285 0 0 0 0 [[17, 274]] 1.0 9czx STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9BJ1B 5 293 833.0 A1APQ:60307 Type1.5_Back Inactive DFGin 7.037 13.81 BLAminus -140.55, 172.82 64.02, 87.63 -97.29, 21.1 289.69, 88.26 -60.45, -45.75 in-in in 8.872 Saltbr-in 2.732 HRD-in -88.62, -54.15 69.86, 7.97 in-out-out SNCioo out-out ActLoopNT-out 6.1 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -85.03, -20.64 APE9-dihe-na 69.49, -145.44 APE8-dihe-in -88.44, 115.74 APE8-rot-out 46.21 APE67-dihe-in -65.1, -22.62 -98.35, 16.87 APE12-dist-out 19.307 APE11-dist-out 20.333 APE10-dist-out 21.769 APE9-dist-out 28.153 None None None XRAY 2.18 0.176 0.228 B 311 289 0 0 0 0 [[17, 274]] 1.0 9bj1 STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7KACA 7 304 833.0 W9D:401 Type1 Inactive DFGin 8.022 14.805 None -141.48, 167.09 66.93, 78.4 -88.8, 999.0 297.14, 96.79 999.0, 999.0 out-out out 12.754 Saltbr-out 11.254 HRD-in -70.03, -49.57 71.67, 0.31 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -89.52, 94.35 APE9-dihe-na 120.85, -175.69 APE8-dihe-in -107.35, 147.06 APE8-rot-out 190.1 APE67-dihe-in -53.56, -32.93 -92.41, -14.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 26.986 L221D,F225E None None XRAY 1.85 0.217 0.232 A 340 283 15 0 0 15 [[17, 274]] 1.0 7kac STE_MAP4K1_HUMAN STE 4.2e-91 310.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9H8DA 7 293 833.0 A1ITC:301 Type1 Inactive DFGin 4.623 14.038 None -56.45, -37.26 -153.97, -176.48 -89.45, 20.13 56.87, 83.02 106.24, -162.07 out-out out 13.393 Saltbr-out 11.411 HRD-in -65.3, -52.29 59.62, 17.42 out-out-out SNCooo out-out ActLoopNT-out 6.941 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -60.47, -36.02 APE9-dihe-na -87.07, -11.18 APE8-dihe-in -151.76, 75.87 APE8-rot-out 169.0 APE67-dihe-in -55.43, -30.79 -91.48, 7.95 APE12-dist-in 9.289 APE11-dist-in 10.207 APE10-dist-out 13.999 APE9-dist-out 12.455 T165E,S171E None None XRAY 1.641 0.199 0.226 A 294 287 0 0 0 0 [[17, 274]] 1.0 9h8d STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9H8EA 7 293 833.0 A1ITA:301 Type1 Inactive DFGin 4.871 13.643 None -54.93, -36.87 -153.52, -178.14 -86.71, 13.52 57.7, 54.93 110.72, -162.78 out-out out 13.244 Saltbr-out 11.94 HRD-in -64.82, -60.03 68.16, 15.68 out-out-out SNCooo out-out ActLoopNT-out 7.428 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -56.89, -34.7 APE9-dihe-na -89.78, -12.26 APE8-dihe-in -151.93, 70.96 APE8-rot-out 171.34 APE67-dihe-in -55.35, -30.86 -85.9, 6.53 APE12-dist-in 9.316 APE11-dist-in 10.439 APE10-dist-out 14.104 APE9-dist-out 12.387 T165E,S171E None None XRAY 1.631 0.195 0.218 A 294 287 0 0 0 0 [[17, 274]] 1.0 9h8e STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9H8FA 7 293 833.0 A1ITB:301 Type1 Inactive DFGin 4.705 13.378 None -52.93, -40.35 -154.71, -177.86 -83.04, 10.74 51.93, 61.71 106.06, -156.77 out-out out 13.504 Saltbr-out 12.054 HRD-in -67.59, -55.04 63.7, 17.96 out-out-out SNCooo out-out ActLoopNT-out 7.349 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -58.32, -34.33 APE9-dihe-na -89.38, -1.89 APE8-dihe-in -161.32, 73.17 APE8-rot-out 170.41 APE67-dihe-in -57.59, -27.85 -94.08, 8.2 APE12-dist-in 9.175 APE11-dist-in 10.305 APE10-dist-out 14.04 APE9-dist-out 12.303 T165E,S171E None None XRAY 1.393 0.203 0.246 A 294 287 0 0 0 0 [[17, 274]] 1.0 9h8f STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9QT6A 6 292 833.0 A1JAF:301 Type1 Inactive DFGin 6.463 13.765 None -60.93, -35.58 -154.04, -176.9 -79.86, 1.42 63.88, 19.01 105.02, -157.57 out-out out 13.28 Saltbr-out 10.782 HRD-in -74.09, -55.53 70.27, 5.38 out-out-out SNCooo out-out ActLoopNT-out 7.582 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -59.89, -40.77 APE9-dihe-na -92.18, -16.28 APE8-dihe-in -142.86, 74.69 APE8-rot-in 316.27 APE67-dihe-in -56.11, -27.62 -91.41, -1.8 APE12-dist-in 9.809 APE11-dist-in 11.134 APE10-dist-out 15.153 APE9-dist-out 12.698 T165E,S171E None None XRAY 1.76 0.198 0.226 A 294 285 2 0 0 0 [[17, 274]] 1.0 9qt6 STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
6NG0A 6 302 833.0 B49:9000 Type1 Inactive DFGin 5.141 15.065 None -69.74, 172.09 -58.45, 155.47 -142.74, 154.55 54.54, 93.56 67.99, -7.56 out-out out 12.858 Saltbr-out 10.815 HRD-in -63.9, -48.24 77.74, -8.02 out-out-out SNCooo out-out ActLoopNT-out 10.601 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -51.88, -33.41 APE9-dihe-na -72.94, -17.4 APE8-dihe-in -134.99, 76.22 APE8-rot-in 306.88 APE67-dihe-in -54.91, -28.64 -97.55, -2.9 APE12-dist-out 23.075 APE11-dist-out 25.012 APE10-dist-out 24.594 APE9-dist-out 28.735 T165E,S171E None None XRAY 2.05 0.202 0.229 A 309 289 8 0 0 5 [[17, 274]] 1.0 6ng0 STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
6CQFA 6 293 833.0 F97:301 Type1 Inactive DFGin 4.938 15.018 None -68.84, 171.73 -65.96, 157.38 -148.76, 145.95 51.62, 92.75 82.89, -6.34 out-out out 12.948 Saltbr-out 11.471 HRD-in -70.81, -45.95 79.09, -18.39 out-out-out SNCooo out-out ActLoopNT-out 10.287 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na 52.73, 67.51 APE9-dihe-na 130.19, -174.52 APE8-dihe-in -127.23, 115.01 APE8-rot-in 316.68 APE67-dihe-in -61.16, -24.43 -41.69, -51.15 APE12-dist-out 15.318 APE11-dist-out 16.648 APE10-dist-out 20.688 APE9-dist-out 21.386 None None None XRAY 2.246 0.21 0.255 A 297 282 6 0 0 6 [[17, 274]] 1.0 6cqf STE_MAP4K1_HUMAN STE 4e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7R9LA 7 293 833.0 2YE:60301 Type1 Inactive DFGin 5.371 15.871 None -79.3, 179.17 -65.19, 145.46 -137.47, 150.51 63.11, 101.31 78.13, -24.94 out-out out 13.256 Saltbr-out 11.156 HRD-in -72.62, -38.36 76.08, -17.52 out-out-out SNCooo out-out ActLoopNT-out 9.297 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -49.77 APE9-dihe-na 168.11, -141.43 APE8-dihe-in -134.99, 123.61 APE8-rot-in 309.2 APE67-dihe-in -71.83, -29.15 -51.51, -37.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.951 APE9-dist-out 20.567 None None None XRAY 2.332 0.23 0.284 A 297 281 6 0 0 6 [[17, 274]] 1.0 7r9l STE_MAP4K1_HUMAN STE 4e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7L26A 8 294 833.0 XHM:301 Type1 Inactive DFGin 5.165 15.699 None -90.65, 167.41 -51.45, 151.26 -138.89, 999.0 46.52, 93.57 999.0, 999.0 out-out out 13.649 Saltbr-out 12.266 HRD-in -70.63, -54.99 86.79, -28.34 out-out-out SNCooo out-out ActLoopNT-out 11.408 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -80.69, -41.73 APE9-dihe-na 172.07, -144.25 APE8-dihe-in -123.38, 126.59 APE8-rot-in 309.45 APE67-dihe-in -64.56, -28.61 -52.67, -44.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.76 S171A,G191C None None XRAY 2.3 0.263 0.298 A 287 280 7 0 0 3 [[17, 274]] 1.0 7l26 STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7L26B 8 294 833.0 XHM:301 Type1 Inactive DFGin 5.053 15.91 None -91.19, 163.6 -51.51, 146.14 -129.86, 999.0 50.48, 91.75 999.0, 999.0 out-out out 13.395 Saltbr-out 10.525 HRD-in -70.31, -53.37 86.88, -29.66 out-out-out SNCooo out-out ActLoopNT-out 11.643 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, -41.02 APE9-dihe-na -160.51, -140.31 APE8-dihe-in -120.3, 127.28 APE8-rot-in 312.21 APE67-dihe-in -60.79, -31.57 -54.68, -45.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.977 S171A,G191C None None XRAY 2.3 0.263 0.298 B 287 275 12 0 0 7 [[17, 274]] 1.0 7l26 STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7L26C 8 294 833.0 XHM:301 Type1 Inactive DFGin 5.239 15.713 None -90.03, 164.23 -51.57, 154.12 -136.67, 999.0 47.02, 92.8 999.0, 999.0 out-out out 13.519 Saltbr-out 12.211 HRD-in -69.66, -55.84 84.96, -26.68 out-out-out SNCooo out-out ActLoopNT-out 11.356 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -82.36, -41.22 APE9-dihe-na 172.52, -152.31 APE8-dihe-in -119.13, 126.23 APE8-rot-in 306.88 APE67-dihe-in -64.39, -28.24 -51.56, -46.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.638 S171A,G191C None None XRAY 2.3 0.263 0.298 C 287 280 7 0 0 3 [[17, 274]] 1.0 7l26 STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7L26D 8 294 833.0 XHM:301 Type1 Inactive DFGin 5.178 15.724 None -92.34, 166.71 -52.02, 146.05 -132.39, 999.0 51.2, 93.07 999.0, 999.0 out-out out 13.064 Saltbr-out 11.471 HRD-in -69.0, -53.47 85.02, -28.41 out-out-out SNCooo out-out ActLoopNT-out 10.874 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -61.1, -36.36 APE9-dihe-na -126.65, -143.86 APE8-dihe-in -116.21, 125.85 APE8-rot-in 315.3 APE67-dihe-in -62.16, -30.12 -53.98, -45.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.683 S171A,G191C None None XRAY 2.3 0.263 0.298 D 287 275 12 0 0 7 [[17, 274]] 1.0 7l26 STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7L25A 7 294 833.0 XHS:301 Type1 Inactive DFGin 4.883 15.036 None -55.28, -37.86 -159.35, -176.67 -80.39, 10.23 63.68, 79.5 109.4, -154.39 out-out out 13.357 Saltbr-out 10.987 HRD-in -68.56, -54.21 74.19, 0.12 out-out-out SNCooo out-out ActLoopNT-out 6.93 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -67.83, -24.29 APE9-dihe-na 79.98, -160.78 APE8-dihe-in -62.61, 131.99 APE8-rot-out 193.6 APE67-dihe-in -64.53, -27.32 -96.3, 1.86 APE12-dist-in 12.785 APE11-dist-in 12.327 APE10-dist-out 11.319 APE9-dist-out 9.214 S171A,G191C None None XRAY 1.85 0.187 0.227 A 289 288 0 0 0 0 [[17, 274]] 1.0 7l25 STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7L25B 6 293 833.0 XHS:301 Type1 Inactive DFGin 4.692 15.194 None -55.03, -37.48 -157.98, -176.29 -82.32, 12.4 61.67, 77.66 107.44, -152.88 out-out out 14.055 Saltbr-out 11.455 HRD-in -67.3, -54.15 74.75, -2.09 out-out-out SNCooo out-out ActLoopNT-out 6.939 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -67.95, -23.75 APE9-dihe-na 79.88, -158.91 APE8-dihe-in -63.36, 133.86 APE8-rot-out 194.95 APE67-dihe-in -65.2, -27.32 -96.05, 0.4 APE12-dist-in 12.75 APE11-dist-in 12.198 APE10-dist-out 11.462 APE9-dist-out 9.201 S171A,G191C None None XRAY 1.85 0.187 0.227 B 289 288 0 0 0 0 [[17, 274]] 1.0 7l25 STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7SIUA 5 294 833.0 9ID:60901 Type1.5_Back Inactive DFGin 3.837 13.895 None -51.62, -38.18 -156.43, -174.28 -96.36, 21.52 50.92, 94.98 81.37, -133.4 out-out out 13.418 Saltbr-out 9.847 HRD-in -75.88, -56.67 70.34, 5.7 out-out-out SNCooo out-out ActLoopNT-out 6.983 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -60.93, -38.93 APE9-dihe-na 77.72, -173.74 APE8-dihe-in -55.84, 129.92 APE8-rot-out 190.44 APE67-dihe-in -64.04, -19.87 -98.67, -1.07 APE12-dist-out 14.742 APE11-dist-in 11.943 APE10-dist-out 11.923 APE9-dist-out 18.051 None None None XRAY 1.786 0.187 0.205 A 310 290 0 0 0 0 [[17, 274]] 1.0 7siu STE_MAP4K1_HUMAN STE 4e-91 310.9 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7SIUB 16 294 833.0 9ID:60301 Type1.5_Back Inactive DFGin 5.076 13.483 None -53.44, -36.92 -155.11, -179.05 -87.99, 18.37 47.54, 74.7 106.16, -161.65 out-out out 12.383 Saltbr-out 8.79 HRD-in -71.24, -52.8 63.02, 13.42 out-out-out SNCooo out-out ActLoopNT-out 7.165 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -100.2, -45.71 APE9-dihe-na 128.51, -162.4 APE8-dihe-in -63.73, 151.22 APE8-rot-out 52.58 APE67-dihe-in -59.58, -25.5 -100.41, 4.16 APE12-dist-out 16.955 APE11-dist-out 16.612 APE10-dist-out 17.1 APE9-dist-out 21.748 None None None XRAY 1.786 0.187 0.205 B 310 279 0 0 0 0 [[17, 274]] 1.0 7siu STE_MAP4K1_HUMAN STE 4e-91 310.9 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9BI8A 6 293 833.0 A1APL:60301 Type1 Inactive DFGinter 10.88 6.392 None -84.61, 129.22 -97.99, 100.09 -110.18, 33.34 298.01, 131.21 -69.67, 73.48 out-out out 13.764 Saltbr-out 14.074 HRD-in -72.89, -53.57 81.64, -15.14 out-out-out SNCooo out-out ActLoopNT-out 12.228 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -88.01, -22.61 APE9-dihe-na 97.47, -162.62 APE8-dihe-in -70.31, 141.95 APE8-rot-out 187.73 APE67-dihe-in -58.8, -30.03 -104.05, -8.58 APE12-dist-out 20.556 APE11-dist-out 20.704 APE10-dist-out 21.839 APE9-dist-out 20.928 None None None XRAY 2.25 0.203 0.271 A 311 288 0 0 0 0 [[17, 274]] 1.0 9bi8 STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9BI8B 6 293 833.0 A1APL:60302 Type1 Inactive DFGinter 10.74 6.23 None -97.5, 135.14 -108.73, 95.26 -106.77, 39.31 297.68, 134.76 -83.18, 62.11 out-out out 13.997 Saltbr-out 14.039 HRD-in -72.45, -53.25 76.92, -14.23 out-out-out SNCooo out-out ActLoopNT-out 12.839 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -130.02, -27.74 APE9-dihe-na 93.81, 172.9 APE8-dihe-in -65.36, 145.02 APE8-rot-out 198.59 APE67-dihe-in -58.71, -28.43 -102.52, -7.42 APE12-dist-out 22.486 APE11-dist-out 22.102 APE10-dist-out 20.6 APE9-dist-out 22.057 None None None XRAY 2.25 0.203 0.271 B 311 288 0 0 0 0 [[17, 274]] 1.0 9bi8 STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9N9XA 6 293 833.0 A1BWL:60303 Type1 Inactive DFGinter 10.661 6.351 None -84.76, 134.66 -105.03, 107.01 -114.17, 28.48 294.9, 125.35 -58.6, 75.75 out-out out 13.958 Saltbr-out 13.908 HRD-in -69.29, -54.46 84.81, -14.35 out-out-out SNCooo out-out ActLoopNT-out 12.469 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.99, -16.32 APE9-dihe-na 85.41, -173.0 APE8-dihe-in -61.5, 138.0 APE8-rot-out 189.55 APE67-dihe-in -57.89, -33.43 -97.6, -11.25 APE12-dist-out 20.846 APE11-dist-out 20.756 APE10-dist-out 21.579 APE9-dist-out 20.677 None None None XRAY 2.3 0.227 0.276 A 311 288 0 0 0 0 [[17, 274]] 1.0 9n9x STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9N9XB 5 293 833.0 A1BWL:60303 Type1 Inactive DFGinter 10.659 6.162 None -80.37, 148.27 -120.58, 99.48 -108.65, 34.73 297.74, 123.66 -67.08, 76.96 out-out out 14.045 Saltbr-out 13.883 HRD-in -72.97, -55.95 86.29, -23.53 out-out-out SNCooo out-out ActLoopNT-out 13.033 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -142.31, -31.43 APE9-dihe-na 78.86, 177.37 APE8-dihe-in -56.88, 138.49 APE8-rot-out 57.19 APE67-dihe-in -66.47, -29.19 -92.99, -1.5 APE12-dist-out 21.885 APE11-dist-out 21.794 APE10-dist-out 20.426 APE9-dist-out 22.322 None None None XRAY 2.3 0.227 0.276 B 311 289 0 0 0 0 [[17, 274]] 1.0 9n9x STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7M0KA 6 294 833.0 YK7:301 Type1 Inactive DFGout 14.38 9.282 BBAminus -82.3, 127.5 -108.13, 109.39 -92.58, 8.94 296.45, 85.82 -60.45, -29.18 out-out out 12.684 Saltbr-out 10.589 HRD-in -69.78, -44.39 74.68, -4.23 out-out-out SNCooo out-out ActLoopNT-out 10.041 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -64.61, -29.22 APE9-dihe-na 78.69, -174.49 APE8-dihe-in -60.92, 129.35 APE8-rot-out 191.1 APE67-dihe-in -68.64, -29.1 -96.97, -0.09 APE12-dist-out 18.536 APE11-dist-out 18.248 APE10-dist-out 18.348 APE9-dist-out 21.588 None None None XRAY 2.01 0.248 0.278 A 289 289 0 0 0 0 [[17, 274]] 1.0 7m0k STE_MAP4K1_HUMAN STE 3.8e-92 314.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7M0KB 8 294 833.0 YK7:301 Type1 Inactive DFGout 14.556 9.244 BBAminus -84.24, 127.09 -106.78, 108.88 -92.96, 3.49 301.42, 86.85 -59.34, -32.37 out-out out 13.258 Saltbr-out 10.295 HRD-in -69.73, -43.43 74.85, -2.63 out-out-out SNCooo out-out ActLoopNT-out 10.733 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -68.65, -29.31 APE9-dihe-na 76.74, -172.39 APE8-dihe-in -61.0, 130.59 APE8-rot-out 51.68 APE67-dihe-in -68.9, -29.49 -91.58, -0.02 APE12-dist-out 18.527 APE11-dist-out 17.326 APE10-dist-out 17.979 APE9-dist-out 21.377 None None None XRAY 2.01 0.248 0.278 B 289 287 0 0 0 0 [[17, 274]] 1.0 7m0k STE_MAP4K1_HUMAN STE 3.8e-92 314.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7M0KC 8 294 833.0 YK7:301 Type1 Inactive DFGout 14.747 9.193 BBAminus -83.02, 126.6 -104.83, 108.45 -92.61, 4.19 299.55, 86.73 -58.9, -32.52 out-out out 13.052 Saltbr-out 10.865 HRD-in -69.81, -43.58 74.75, -1.63 out-out-out SNCooo out-out ActLoopNT-out 10.739 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -68.31, -28.22 APE9-dihe-na 77.87, -176.3 APE8-dihe-in -60.14, 130.51 APE8-rot-out 51.57 APE67-dihe-in -68.87, -29.91 -92.31, -0.75 APE12-dist-out 18.58 APE11-dist-out 17.484 APE10-dist-out 17.883 APE9-dist-out 21.188 None None None XRAY 2.01 0.248 0.278 C 289 287 0 0 0 0 [[17, 274]] 1.0 7m0k STE_MAP4K1_HUMAN STE 3.8e-92 314.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7M0KD 6 294 833.0 YK7:301 Type1 Inactive DFGout 14.184 9.527 BBAminus -83.63, 126.84 -106.68, 106.05 -94.4, 6.0 302.62, 86.87 -62.71, -28.5 out-out out 12.654 Saltbr-out 9.241 HRD-in -69.65, -44.42 75.51, -4.67 out-out-out SNCooo out-out ActLoopNT-out 10.084 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -64.4, -29.63 APE9-dihe-na 78.61, -174.89 APE8-dihe-in -60.94, 129.64 APE8-rot-out 191.32 APE67-dihe-in -67.7, -29.48 -96.47, 0.29 APE12-dist-out 18.251 APE11-dist-out 17.87 APE10-dist-out 17.914 APE9-dist-out 21.542 None None None XRAY 2.01 0.248 0.278 D 289 289 0 0 0 0 [[17, 274]] 1.0 7m0k STE_MAP4K1_HUMAN STE 3.8e-92 314.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7M0LA 6 294 833.0 YK4:301 Type1 Inactive DFGout 14.902 10.045 BBAminus -71.28, 178.03 -141.2, 104.43 -97.3, 46.95 304.49, 90.24 -84.8, -71.52 out-out out 13.467 Saltbr-out 11.202 HRD-in -68.11, -44.69 74.67, -1.39 out-out-out SNCooo out-out ActLoopNT-out 9.998 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -57.77, -34.08 APE9-dihe-na 74.25, 174.22 APE8-dihe-in -46.91, 123.76 APE8-rot-out 49.48 APE67-dihe-in -66.71, -32.87 -89.18, 0.28 APE12-dist-out 18.95 APE11-dist-out 19.692 APE10-dist-out 18.759 APE9-dist-out 21.445 None None None XRAY 2.43 0.247 0.293 A 290 289 0 0 0 0 [[17, 274]] 1.0 7m0l STE_MAP4K1_HUMAN STE 3.9e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7M0LB 7 291 833.0 YK4:301 Type1 Inactive DFGout 15.61 10.209 BBAminus -70.94, 176.88 -141.02, 102.53 -97.9, 45.28 304.85, 90.25 -88.09, -75.03 out-out out 13.727 Saltbr-out 11.209 HRD-in -66.64, -44.4 75.03, -0.95 out-out-out SNCooo out-out ActLoopNT-out 10.439 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -58.84, -34.7 APE9-dihe-na 74.6, 170.86 APE8-dihe-in -43.86, 123.95 APE8-rot-out 48.0 APE67-dihe-in -67.03, -32.95 -86.15, -1.97 APE12-dist-out 18.821 APE11-dist-out 19.065 APE10-dist-out 18.033 APE9-dist-out 21.124 None None None XRAY 2.43 0.247 0.293 B 290 285 0 0 0 0 [[17, 274]] 1.0 7m0l STE_MAP4K1_HUMAN STE 3.9e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7M0LC 5 293 833.0 YK4:301 Type1 Inactive DFGout 15.53 10.394 BBAminus -71.65, 178.05 -140.2, 103.38 -97.38, 46.57 306.96, 90.71 -89.66, -75.36 out-out out 13.736 Saltbr-out 11.256 HRD-in -66.05, -45.63 75.21, -1.09 out-out-out SNCooo out-out ActLoopNT-out 10.542 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -56.43, -35.65 APE9-dihe-na 76.18, 166.86 APE8-dihe-in -44.06, 124.4 APE8-rot-out 47.86 APE67-dihe-in -66.88, -33.48 -86.46, -1.75 APE12-dist-out 18.956 APE11-dist-out 19.052 APE10-dist-out 17.978 APE9-dist-out 20.967 None None None XRAY 2.43 0.247 0.293 C 290 289 0 0 0 0 [[17, 274]] 1.0 7m0l STE_MAP4K1_HUMAN STE 3.9e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
7M0LD 6 294 833.0 YK4:301 Type1 Inactive DFGout 15.055 10.164 BBAminus -71.92, 179.1 -140.53, 104.62 -96.34, 48.54 303.88, 89.32 -84.2, -73.4 out-out out 13.331 Saltbr-out 10.975 HRD-in -67.59, -45.21 75.46, -2.9 out-out-out SNCooo out-out ActLoopNT-out 10.088 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -59.91, -35.42 APE9-dihe-na 70.42, 178.96 APE8-dihe-in -46.62, 123.18 APE8-rot-out 48.98 APE67-dihe-in -68.16, -32.32 -90.56, -1.23 APE12-dist-out 18.879 APE11-dist-out 19.363 APE10-dist-out 18.66 APE9-dist-out 21.346 None None None XRAY 2.43 0.247 0.293 D 290 289 0 0 0 0 [[17, 274]] 1.0 7m0l STE_MAP4K1_HUMAN STE 3.9e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8XN7A 6 292 833.0 A1LVT:301 Type1 Inactive DFGout 14.345 8.503 BBAminus -88.75, 151.47 -138.7, 126.73 -107.63, 21.41 291.25, 85.46 -71.58, -35.21 out-out out 12.452 Saltbr-out 9.821 HRD-in -58.31, -58.38 91.57, -25.59 out-out-out SNCooo out-out ActLoopNT-out 10.863 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -64.68, -28.8 APE9-dihe-na 70.41, -167.61 APE8-dihe-in -58.65, 130.58 APE8-rot-in 298.7 APE67-dihe-in -73.02, -31.33 -104.12, 4.31 APE12-dist-out 17.739 APE11-dist-out 17.886 APE10-dist-out 17.981 APE9-dist-out 22.532 T165E,S171E None None XRAY 2.65 0.216 0.23 A 296 287 0 0 0 0 [[17, 274]] 1.0 8xn7 STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8XN7B 6 293 833.0 A1LVT:301 Type1 Inactive DFGout 14.344 8.441 BBAminus -88.25, 152.38 -137.37, 125.89 -108.54, 21.47 292.51, 85.61 -69.84, -31.75 out-out out 12.646 Saltbr-out 9.784 HRD-in -65.26, -49.86 82.38, -14.29 out-out-out SNCooo out-out ActLoopNT-out 11.266 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -70.2, -26.89 APE9-dihe-na 72.95, -172.4 APE8-dihe-in -61.15, 131.32 APE8-rot-in 303.09 APE67-dihe-in -73.29, -31.98 -103.73, 3.33 APE12-dist-out 17.784 APE11-dist-out 16.391 APE10-dist-out 16.978 APE9-dist-out 21.515 T165E,S171E None None XRAY 2.65 0.216 0.23 B 296 288 0 0 0 0 [[17, 274]] 1.0 8xn7 STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
6NG0B 7 293 833.0 B49:9000 Type1 Inactive DFGout 15.022 9.027 BBAminus -132.93, 173.24 -130.35, 91.11 -75.14, -30.73 272.68, 88.14 -91.62, -130.52 out-out out 11.213 Saltbr-out 7.483 HRD-in -72.09, -46.07 68.34, -7.21 out-out-out SNCooo out-out ActLoopNT-out 6.11 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.37, 118.48 APE9-dihe-na -63.42, 177.66 APE8-dihe-in -42.4, 131.86 APE8-rot-out 56.61 APE67-dihe-in -50.2, -28.57 -93.94, -13.91 APE12-dist-out 19.976 APE11-dist-out 20.334 APE10-dist-out 21.461 APE9-dist-out 26.729 T165E,S171E None None XRAY 2.05 0.202 0.229 B 309 279 8 0 0 0 [[17, 274]] 1.0 6ng0 STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9BIKA 6 293 833.0 A1APO:60305 Type1 Inactive DFGout 11.049 6.429 BBAminus -86.09, 138.02 -107.53, 93.71 -107.56, 23.89 298.14, 124.18 -51.45, -27.27 out-out out 13.789 Saltbr-out 15.086 HRD-in -65.37, -54.34 81.94, -7.09 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -75.89, -68.71 APE9-dihe-na 67.03, -121.46 APE8-dihe-in -103.1, 131.35 APE8-rot-out 193.66 APE67-dihe-in -68.7, -24.1 -99.33, 8.23 APE12-dist-out 18.958 APE11-dist-out 18.254 APE10-dist-out 18.059 APE9-dist-out 25.386 None None None XRAY 2.25 0.199 0.244 A 311 277 11 0 0 9 [[17, 274]] 1.0 9bik STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9N7RB 8 293 833.0 A1BWC:60303 Type1 Inactive DFGout 13.297 7.461 BBAminus -95.98, 130.04 -92.56, 107.91 -107.94, 11.95 278.7, 152.36 -51.43, -31.57 out-out out 14.109 Saltbr-out 11.998 HRD-in -70.53, -47.56 77.61, -10.23 out-out-out SNCooo out-out ActLoopNT-out 10.003 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -82.83, -34.63 APE9-dihe-na 119.15, 153.13 APE8-dihe-in -69.07, 159.39 APE8-rot-out 47.32 APE67-dihe-in -62.98, -31.32 -84.37, -15.77 APE12-dist-out 18.622 APE11-dist-out 18.323 APE10-dist-out 17.047 APE9-dist-out 19.026 None None None XRAY 2.13 0.181 0.227 B 311 286 0 0 0 0 [[17, 274]] 1.0 9n7r STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
9N7RA 6 293 833.0 A1BWC:60311,A1BWC:60312,A1BWC:60313,A1BWC:60314 Allosteric,Allosteric,Type1,Type3 Inactive DFGout 17.032 11.8 None -129.06, 178.2 -145.13, 177.54 -61.13, -39.48 183.33, 82.96 102.23, 179.57 out-out out 13.632 Saltbr-out 11.265 HRD-in -73.28, -53.35 86.93, -14.11 out-out-out SNCooo out-out ActLoopNT-out 13.906 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -81.55, -0.66 APE9-dihe-na 85.8, 22.09 APE8-dihe-out 64.18, 169.47 APE8-rot-out 79.18 APE67-dihe-in -67.09, -36.34 -100.57, -1.37 APE12-dist-out 17.862 APE11-dist-out 17.078 APE10-dist-out 17.236 APE9-dist-out 22.488 None None None XRAY 2.13 0.181 0.227 A 311 288 0 0 0 0 [[17, 274]] 1.0 9n7r STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8PAUA 7 294 833.0 XOR:1001 Type1 Inactive DFGout 12.502 8.937 None -85.41, 114.68 -96.13, 139.33 -109.83, 159.8 292.92, 88.01 145.69, 999.0 out-out out 13.219 Saltbr-out 12.099 HRD-in -61.81, -50.9 82.78, -10.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -89.69, -5.15 APE9-dihe-na 127.7, 166.27 APE8-dihe-in -87.46, 130.96 APE8-rot-in 325.04 APE67-dihe-in -54.13, -40.06 -71.53, -24.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.374 None None None XRAY 2.8 0.219 0.272 A 288 276 12 0 0 12 [[17, 274]] 1.0 8pau STE_MAP4K1_HUMAN STE 1.3e-92 315.7 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8PAUB 7 294 833.0 XOR:1001 Type1 Inactive DFGout 12.519 8.959 None -85.91, 115.0 -96.04, 138.99 -110.13, 158.13 294.35, 88.25 150.56, 999.0 out-out out 13.341 Saltbr-out 12.444 HRD-in -60.94, -50.68 83.07, -11.96 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -89.71, -5.01 APE9-dihe-na 125.94, 168.22 APE8-dihe-in -87.62, 131.63 APE8-rot-in 327.51 APE67-dihe-in -53.89, -40.26 -71.12, -25.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.51 None None None XRAY 2.8 0.219 0.272 B 288 276 12 0 0 12 [[17, 274]] 1.0 8pau STE_MAP4K1_HUMAN STE 1.3e-92 315.7 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8PASA 8 295 833.0 XOH:1001 Type1 Inactive DFGout 17.194 11.34 None -102.48, 172.96 -123.06, 91.61 -76.46, -45.21 184.61, 68.06 -62.9, -137.65 out-out out 12.746 Saltbr-out 10.388 HRD-in -71.47, -49.47 84.52, -7.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 81.11 APE8-rot-out 192.88 APE67-dihe-in -41.49, -47.96 -71.33, -32.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.231 0.3 A 289 269 19 0 0 15 [[17, 274]] 1.0 8pas STE_MAP4K1_HUMAN STE 1.4e-92 315.6 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8PASB 7 294 833.0 XOH:1001 Type1 Inactive DFGout 16.527 8.559 None -98.04, 164.09 -125.71, 93.21 -79.27, -45.4 197.01, 39.14 -93.06, 64.56 out-out out 13.068 Saltbr-out 11.979 HRD-in -70.58, -50.51 83.73, -9.49 out-out-out SNCooo out-out ActLoopNT-out 11.835 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 116.66 APE8-rot-out 72.4 APE67-dihe-in -39.94, -48.63 -94.09, -15.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.231 0.3 B 289 273 15 0 0 12 [[17, 274]] 1.0 8pas STE_MAP4K1_HUMAN STE 1.4e-92 315.6 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8CDWA 7 294 833.0 UES:401 Type1 Inactive DFGout 12.943 10.181 None -88.94, 138.44 -85.59, 110.01 -95.36, 999.0 303.83, 5.34 999.0, 999.0 out-out out 12.997 Saltbr-out 12.142 HRD-in -68.21, -45.06 72.04, -15.38 out-out-out SNCooo out-out ActLoopNT-out 9.782 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -61.85, -37.25 APE9-dihe-na 89.35, -173.76 APE8-dihe-in -63.78, 133.43 APE8-rot-out 48.38 APE67-dihe-in -57.9, -34.4 -95.8, -2.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 21.11 None None None XRAY 1.941 0.229 0.252 A 307 285 3 0 0 3 [[17, 274]] 1.0 8cdw STE_MAP4K1_HUMAN STE 4.8e-92 313.9 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8CIJA 14 294 833.0 USF:401 Type1 Inactive DFGout 11.213 7.331 None -112.58, 122.54 -96.1, 115.56 -121.01, 999.0 297.98, 106.95 999.0, 999.0 out-out out 13.535 Saltbr-out 11.8 HRD-in -61.67, -48.53 69.18, 2.25 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -87.98, 122.06 APE9-dihe-na 145.78, 142.84 APE8-dihe-in -120.8, 116.13 APE8-rot-in 320.07 APE67-dihe-in -58.16, -27.75 -31.5, -57.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.681 None None None XRAY 2.821 0.239 0.266 A 307 264 17 0 0 12 [[17, 274]] 1.0 8cij STE_MAP4K1_HUMAN STE 4.8e-92 313.9 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8PARA 7 294 833.0 XON:402 Type1 Inactive DFGout 14.971 8.334 None -85.12, 139.88 -106.78, 86.97 -93.71, -153.54 212.58, 74.65 90.72, 999.0 out-out out 14.169 Saltbr-out 12.168 HRD-in -64.66, -52.5 81.78, -15.49 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 169.98 APE8-dihe-in -64.02, 158.26 APE8-rot-out 59.07 APE67-dihe-in -62.49, -27.18 -94.28, 3.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 21.369 T165E,S171E None None XRAY 2.0 0.242 0.292 A 308 268 20 0 0 16 [[17, 274]] 1.0 8par STE_MAP4K1_HUMAN STE 4.8e-92 313.9 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8FKOF 57 292 833.0 No_ligand No_ligand Inactive None 6.584 999.0 None -130.11, 169.82 68.72, 80.6 -90.27, 25.22 286.89, 93.32 -62.48, -41.27 none-none none 999.0 Saltbr-none 999.0 HRD-in -79.1, -46.03 67.61, -7.09 none-out-out SNCnoo out-out ActLoopNT-out 6.119 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -65.82, -29.85 APE9-dihe-na 74.43, -162.11 APE8-dihe-in -54.25, 130.28 APE8-rot-out 204.88 APE67-dihe-in -55.84, -31.2 -100.45, -5.05 APE12-dist-out 19.323 APE11-dist-out 21.012 APE10-dist-out 21.979 APE9-dist-out 27.951 T165E,S171E None None XRAY 2.104 0.222 0.258 F 331 224 52 0 0 0 [[17, 274]] 1.0 8fko STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
6CQEA 4 293 833.0 No_ligand No_ligand Inactive None 13.3 16.89 None -78.38, 159.45 -80.15, 141.12 -104.62, -37.54 162.44, 74.03 -60.06, -40.87 out-out out 13.207 Saltbr-out 10.933 HRD-in -68.12, -50.77 83.16, -16.98 out-out-out SNCooo out-out ActLoopNT-out 11.022 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -125.75, 162.38 APE9-dihe-na -83.75, 166.4 APE8-dihe-in -86.5, 169.52 APE8-rot-out 55.14 APE67-dihe-in -56.39, -35.1 -100.47, 3.45 APE12-dist-out 21.498 APE11-dist-out 18.233 APE10-dist-out 16.536 APE9-dist-out 20.671 S171A None None XRAY 1.886 0.207 0.258 A 295 286 4 0 0 0 [[17, 274]] 1.0 6cqe STE_MAP4K1_HUMAN STE 3.9e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
6CQEB 5 293 833.0 No_ligand No_ligand Inactive None 13.606 16.666 None -80.76, 157.28 -74.99, 140.01 -104.91, -33.72 170.4, 64.14 -59.17, -42.27 out-out out 13.282 Saltbr-out 11.412 HRD-in -69.42, -46.27 82.96, -17.54 out-out-out SNCooo out-out ActLoopNT-out 11.104 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -124.41, 161.02 APE9-dihe-na -76.12, 165.91 APE8-dihe-in -92.98, 166.38 APE8-rot-out 201.74 APE67-dihe-in -59.03, -29.82 -96.28, -0.42 APE12-dist-out 21.535 APE11-dist-out 18.345 APE10-dist-out 16.557 APE9-dist-out 20.617 S171A None None XRAY 1.886 0.207 0.258 B 295 286 3 0 0 0 [[17, 274]] 1.0 6cqe STE_MAP4K1_HUMAN STE 3.9e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
8CDWB 9 294 833.0 UES:401 Type1 Inactive None 999.0 999.0 None -90.95, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.693 Saltbr-out 9.501 HRD-in -69.3, -45.46 74.3, -15.92 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -164.41 APE8-dihe-in -62.34, 132.44 APE8-rot-out 50.76 APE67-dihe-in -59.34, -31.48 -97.57, 1.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 22.685 None None None XRAY 1.941 0.229 0.252 B 307 265 21 0 0 9 [[17, 274]] 1.0 8cdw STE_MAP4K1_HUMAN STE 4.8e-92 313.9 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
6NFZA 7 292 833.0 B49:401 Type1 None DFGin 6.284 14.02 BLAminus -132.74, -179.97 58.53, 80.12 -96.32, 31.7 293.92, 71.67 -62.29, -28.15 in-none in 8.634 Saltbr-none 999.0 HRD-in -77.39, -48.16 72.34, -9.45 none-in-in SNCnii in-in ActLoopNT-in 2.838 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.28, 161.74 APE9-dihe-na 145.04, -157.57 APE8-dihe-in -127.09, 102.67 APE8-rot-in 298.6 APE67-dihe-in -54.23, -29.76 -34.34, -51.63 APE12-dist-in 8.241 APE11-dist-in 11.626 APE10-dist-in 6.178 APE9-dist-in 3.916 None TPO165,SEP171 TPO165,SEP171 XRAY 2.966 0.209 0.251 A 309 270 16 0 0 0 [[17, 274]] 1.0 6nfz STE_MAP4K1_HUMAN STE 1.7e-92 315.3 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1

STE_MAP4K1 (Mitogen-activated protein kinase kinase kinase kinase 1)

Total number of chains: 104
Active chains: 3
Family: STE
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 57 54.8% AF-Q92918-K1A
DFGin None 16 15.4% 9H8FA
DFGout BBAminus 13 12.5% 7M0KA
DFGout None 8 7.7% 9N7RA
DFGinter None 4 3.8% 9BI8A
None None 4 3.8% 6CQEB
DFGin ABAminus 2 1.9% 6NFYB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
M4K1_HUMAN AF-Q92918-K1A Q92918 9 282 833.0 No_ligand No_ligand Active DFGin 6.385 14.306 BLAminus -137.99, 179.33 58.7, 63.56 -81.89, 12.08 292.52, 84.97 -57.46, -34.33 in-in in 8.834 Saltbr-in 2.736 HRD-in -83.11, -47.12 66.24, 7.46 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.12, 145.19 APE9-dihe-na 133.94, 175.27 APE8-dihe-in -87.36, 125.88 APE8-rot-in 305.87 APE67-dihe-in -73.49, -21.52 -47.83, -45.86 APE12-dist-in 9.081 APE11-dist-in 12.01 APE10-dist-in 6.194 APE9-dist-in 3.426 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[17, 274]] 1.0 AF-Q92918-K1 Homo sapiens STE_MAP4K1_HUMAN STE 1.1e-92 315.9 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN AF-Q92918-K3A Q92918 9 282 833.0 No_ligand No_ligand Active DFGin 6.295 13.921 BLAminus -134.67, 173.63 57.41, 70.5 -81.88, 9.86 290.72, 85.76 -58.96, -31.66 in-in in 8.868 Saltbr-in 2.757 HRD-in -78.36, -44.81 68.44, 4.33 in-in-in SNCiii in-in ActLoopNT-in 2.811 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.01, 146.33 APE9-dihe-na 136.5, 166.99 APE8-dihe-in -77.81, 123.18 APE8-rot-in 304.84 APE67-dihe-in -70.02, -28.12 -47.87, -44.31 APE12-dist-in 8.973 APE11-dist-in 11.841 APE10-dist-in 6.158 APE9-dist-in 3.414 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[17, 274]] 1.0 AF-Q92918-K3 Homo sapiens STE_MAP4K1_HUMAN STE 1.1e-92 315.9 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 6NFZB Q92918 5 292 833.0 B49:9001 Type1 Active DFGin 6.569 14.125 BLAminus -143.42, 177.82 59.84, 65.59 -92.66, 20.58 294.3, 90.38 -59.43, -39.56 in-in in 8.651 Saltbr-in 3.56 HRD-in -78.49, -47.72 65.71, 8.89 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.78, 156.37 APE9-dihe-na 142.37, -174.26 APE8-dihe-in -102.95, 108.5 APE8-rot-in 309.31 APE67-dihe-in -65.17, -28.5 -37.53, -43.95 APE12-dist-in 8.184 APE11-dist-in 11.437 APE10-dist-in 5.975 APE9-dist-in 3.854 None TPO165,SEP171 TPO165,SEP171 XRAY 2.966 0.209 0.251 B 309 277 11 0 0 3 [[17, 274]] 1.0 6nfz Homo sapiens STE_MAP4K1_HUMAN STE 1.7e-92 315.3 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 6NFYA Q92918 10 292 833.0 B49:69000 Type1 Inactive DFGin 5.593 14.914 ABAminus -77.99, -10.08 -165.37, 178.6 -100.73, 5.46 299.9, 89.52 78.01, -158.47 out-out out 11.415 Saltbr-out 8.806 HRD-in -67.76, -54.16 80.53, -5.66 out-out-out SNCooo out-out ActLoopNT-out 5.972 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -122.43, 132.12 APE9-dihe-na -84.67, -151.78 APE8-dihe-in -82.18, 120.44 APE8-rot-in 317.02 APE67-dihe-in -65.57, -25.36 -45.65, -39.38 APE12-dist-in 12.643 APE11-dist-in 8.454 APE10-dist-out 12.901 APE9-dist-in 3.434 None None None XRAY 2.17 0.194 0.219 A 300 280 3 0 0 0 [[17, 274]] 1.0 6nfy Homo sapiens STE_MAP4K1_HUMAN STE 1.6e-92 315.4 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 6NFYB Q92918 10 292 833.0 B49:69000 Type1 Inactive DFGin 5.428 14.439 ABAminus -77.59, -12.73 -160.52, 173.22 -94.5, 5.68 304.19, 88.51 70.4, -157.51 out-out out 11.151 Saltbr-out 8.039 HRD-in -66.24, -54.13 78.28, -9.22 out-out-out SNCooo out-out ActLoopNT-out 6.006 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -128.67, 114.08 APE9-dihe-na -99.5, -109.92 APE8-dihe-in -118.15, 107.47 APE8-rot-in 308.81 APE67-dihe-in -64.32, -24.35 -45.36, -36.49 APE12-dist-out 15.067 APE11-dist-in 10.6 APE10-dist-out 15.129 APE9-dist-in 4.289 None None None XRAY 2.17 0.194 0.219 B 300 283 0 0 0 0 [[17, 274]] 1.0 6nfy Homo sapiens STE_MAP4K1_HUMAN STE 1.6e-92 315.4 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 6CQDA Q92918 2 293 833.0 ANP:60301 ATPlike Inactive DFGin 6.032 13.886 BLAminus -140.97, 178.85 65.6, 83.06 -106.07, 25.72 286.0, 93.85 -58.74, -52.87 in-in in 8.588 Saltbr-in 2.603 HRD-in -75.86, -49.25 70.86, -6.64 in-out-out SNCioo out-out ActLoopNT-out 5.612 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -107.43, -47.34 APE9-dihe-na -128.13, -155.64 APE8-dihe-in -106.29, 135.18 APE8-rot-out 173.28 APE67-dihe-in -57.05, -28.95 -70.03, -34.9 APE12-dist-out 19.71 APE11-dist-out 23.507 APE10-dist-out 22.083 APE9-dist-out 27.312 None None None XRAY 2.12 0.206 0.25 A 297 288 4 0 0 0 [[17, 274]] 1.0 6cqd Homo sapiens STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 6CQDB Q92918 4 293 833.0 ANP:60302 ATPlike Inactive DFGin 6.101 14.229 BLAminus -144.26, -175.8 58.68, 77.54 -93.97, 33.74 292.79, 90.96 -66.13, -50.88 in-in in 9.463 Saltbr-in 3.209 HRD-in -76.3, -46.87 66.26, 5.48 in-out-out SNCioo out-out ActLoopNT-out 6.073 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.26, 126.5 APE9-dihe-na -81.79, -144.73 APE8-dihe-in -66.65, 145.16 APE8-rot-out 188.81 APE67-dihe-in -66.31, -22.65 -105.18, -2.62 APE12-dist-out 20.763 APE11-dist-out 21.959 APE10-dist-out 21.41 APE9-dist-out 27.357 None None None XRAY 2.12 0.206 0.25 B 297 290 0 0 0 0 [[17, 274]] 1.0 6cqd Homo sapiens STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7KACB Q92918 7 294 833.0 W9D:401 Type1 Inactive DFGin 6.478 15.039 BLAminus -142.13, 167.59 65.6, 78.09 -86.94, 22.14 297.43, 93.96 -62.14, -40.27 in-out in 9.485 Saltbr-out 4.11 HRD-in -70.49, -51.21 66.78, 6.45 out-out-out SNCooo out-out ActLoopNT-out 6.37 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -130.57, 137.49 APE9-dihe-na -72.47, -120.59 APE8-dihe-in -59.2, 120.08 APE8-rot-out 43.57 APE67-dihe-in -54.01, -32.53 -81.01, -10.52 APE12-dist-out 17.024 APE11-dist-out 21.076 APE10-dist-out 22.501 APE9-dist-out 28.19 L221D,F225E None None XRAY 1.85 0.217 0.232 B 340 288 0 0 0 0 [[17, 274]] 1.0 7kac Homo sapiens STE_MAP4K1_HUMAN STE 4.2e-91 310.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7M0MA Q92918 2 294 833.0 YK1:301 Type1 Inactive DFGin 6.687 14.597 BLAminus -138.14, 175.74 49.93, 80.08 -88.4, 29.89 288.19, 82.75 -65.83, -47.43 in-in in 8.807 Saltbr-in 2.733 HRD-in -68.9, -51.69 71.01, 3.09 in-out-out SNCioo out-out ActLoopNT-out 6.154 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.06, 129.56 APE9-dihe-na -87.01, -111.4 APE8-dihe-in -115.37, 97.33 APE8-rot-out 42.58 APE67-dihe-in -65.39, -26.85 -90.09, 25.44 APE12-dist-out 19.378 APE11-dist-out 20.699 APE10-dist-out 21.673 APE9-dist-out 28.197 None None None XRAY 1.93 0.188 0.22 A 293 293 0 0 0 0 [[17, 274]] 1.0 7m0m Homo sapiens STE_MAP4K1_HUMAN STE 4e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7M0MB Q92918 3 293 833.0 YK1:301 Type1 Inactive DFGin 6.499 14.094 BLAminus -136.63, 174.09 57.96, 82.75 -88.09, 24.59 290.28, 84.21 -67.07, -46.88 in-in in 8.776 Saltbr-in 2.746 HRD-in -70.12, -50.67 70.12, 6.36 in-out-out SNCioo out-out ActLoopNT-out 6.168 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -62.85, -31.51 APE9-dihe-na 78.15, -165.12 APE8-dihe-in -72.84, 128.05 APE8-rot-out 198.02 APE67-dihe-in -66.84, -29.23 -96.76, -1.39 APE12-dist-out 19.369 APE11-dist-out 20.336 APE10-dist-out 21.816 APE9-dist-out 27.559 None None None XRAY 1.93 0.188 0.22 B 293 291 0 0 0 0 [[17, 274]] 1.0 7m0m Homo sapiens STE_MAP4K1_HUMAN STE 4e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7R9NA Q92918 3 293 833.0 F97:301 Type1 Inactive DFGin 6.175 14.585 BLAminus -146.44, -171.42 55.37, 74.43 -87.26, 17.26 286.52, 100.62 -61.54, -42.57 in-in in 9.099 Saltbr-in 2.99 HRD-in -72.69, -47.96 70.45, -0.15 in-out-out SNCioo out-out ActLoopNT-out 6.369 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.78, -25.66 APE9-dihe-na 77.38, -176.25 APE8-dihe-in -64.1, 139.12 APE8-rot-out 194.57 APE67-dihe-in -67.3, -23.81 -101.42, -2.74 APE12-dist-out 19.377 APE11-dist-out 20.863 APE10-dist-out 21.738 APE9-dist-out 27.684 None None None XRAY 1.5 0.167 0.191 A 297 291 0 0 0 0 [[17, 274]] 1.0 7r9n Homo sapiens STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7R9NB Q92918 4 293 833.0 F97:301 Type1 Inactive DFGin 6.266 15.321 BLAminus -146.02, -177.22 55.93, 75.65 -90.22, 21.38 287.95, 88.23 -62.82, -41.47 in-out in 9.759 Saltbr-out 4.102 HRD-in -72.45, -53.71 75.68, -0.26 out-out-out SNCooo out-out ActLoopNT-out 6.136 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.8, -25.67 APE9-dihe-na 74.93, -177.44 APE8-dihe-in -63.0, 140.67 APE8-rot-out 196.08 APE67-dihe-in -68.28, -21.9 -101.8, -0.97 APE12-dist-out 19.317 APE11-dist-out 20.926 APE10-dist-out 21.759 APE9-dist-out 27.601 None None None XRAY 1.5 0.167 0.191 B 297 286 4 0 0 0 [[17, 274]] 1.0 7r9n Homo sapiens STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7R9PA Q92918 5 293 833.0 2WI:60301 Type1 Inactive DFGin 5.866 14.838 BLAminus -139.47, 175.09 56.52, 93.83 -96.72, 30.24 292.48, 91.02 -62.77, -53.1 in-out in 9.85 Saltbr-out 3.919 HRD-in -72.5, -57.61 75.96, -1.79 out-out-out SNCooo out-out ActLoopNT-out 6.029 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -97.04, -27.64 APE9-dihe-na 91.61, -154.21 APE8-dihe-in -95.68, 123.06 APE8-rot-out 57.95 APE67-dihe-in -65.56, -28.98 -97.36, 11.82 APE12-dist-out 19.512 APE11-dist-out 20.724 APE10-dist-out 22.086 APE9-dist-out 28.437 None None None XRAY 2.27 0.211 0.232 A 297 286 3 0 0 0 [[17, 274]] 1.0 7r9p Homo sapiens STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7R9PB Q92918 3 293 833.0 2WI:60301 Type1 Inactive DFGin 5.945 15.276 BLAminus -143.88, 174.79 53.65, 85.57 -90.15, 26.18 296.0, 90.76 -60.23, -48.45 in-out in 9.857 Saltbr-out 4.513 HRD-in -74.84, -52.47 68.69, 9.44 out-out-out SNCooo out-out ActLoopNT-out 6.388 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -80.16, -17.77 APE9-dihe-na 72.14, -120.36 APE8-dihe-in -113.34, 108.55 APE8-rot-out 53.88 APE67-dihe-in -70.0, -20.38 -93.3, 14.58 APE12-dist-out 19.214 APE11-dist-out 21.113 APE10-dist-out 21.907 APE9-dist-out 28.403 None None None XRAY 2.27 0.211 0.232 B 297 291 0 0 0 0 [[17, 274]] 1.0 7r9p Homo sapiens STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7R9TA Q92918 3 293 833.0 2TR:60301 Type1 Inactive DFGin 6.199 15.021 BLAminus -144.22, 171.46 64.03, 83.98 -91.5, 29.51 294.13, 93.76 -68.67, -43.52 in-out in 9.77 Saltbr-out 4.404 HRD-in -68.79, -58.68 77.22, 3.1 out-out-out SNCooo out-out ActLoopNT-out 6.287 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.84, -26.31 APE9-dihe-na 80.83, -173.28 APE8-dihe-in -66.47, 134.84 APE8-rot-out 189.9 APE67-dihe-in -64.95, -22.68 -106.67, 4.64 APE12-dist-out 19.371 APE11-dist-out 21.086 APE10-dist-out 21.695 APE9-dist-out 27.985 None None None XRAY 2.0 0.2 0.229 A 297 291 0 0 0 0 [[17, 274]] 1.0 7r9t Homo sapiens STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7R9TB Q92918 4 293 833.0 2TR:60301 Type1 Inactive DFGin 6.036 15.503 BLAminus -141.5, 169.57 67.75, 80.3 -94.86, 21.18 292.6, 84.25 -62.92, -43.96 out-out out 10.104 Saltbr-out 3.908 HRD-in -73.53, -49.63 67.47, 8.97 out-out-out SNCooo out-out ActLoopNT-out 6.186 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -83.95, -20.57 APE9-dihe-na 81.97, -175.21 APE8-dihe-in -65.12, 142.45 APE8-rot-out 187.76 APE67-dihe-in -64.59, -24.46 -107.23, 2.56 APE12-dist-out 19.628 APE11-dist-out 21.091 APE10-dist-out 21.866 APE9-dist-out 27.864 None None None XRAY 2.0 0.2 0.229 B 297 284 6 0 0 0 [[17, 274]] 1.0 7r9t Homo sapiens STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9CZTA Q92918 5 292 833.0 A1A1E:401 Type1 Inactive DFGin 6.299 14.335 BLAminus -140.35, 175.62 59.71, 82.27 -89.15, 19.04 288.12, 99.31 -55.34, -49.29 in-in in 8.82 Saltbr-in 2.725 HRD-in -72.27, -52.66 66.08, 4.34 in-out-out SNCioo out-out ActLoopNT-out 6.222 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -80.97, -21.01 APE9-dihe-na 79.81, -158.76 APE8-dihe-in -64.23, 143.11 APE8-rot-out 46.29 APE67-dihe-in -61.81, -23.62 -110.28, 1.48 APE12-dist-out 20.711 APE11-dist-out 20.225 APE10-dist-out 20.996 APE9-dist-out 27.52 T165E,S171E None None XRAY 1.69 0.194 0.219 A 309 288 0 0 0 0 [[17, 274]] 1.0 9czt Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9CZTB Q92918 5 293 833.0 A1A1E:401 Type1 Inactive DFGin 6.219 14.34 BLAminus -146.07, 172.56 61.38, 80.77 -87.95, 18.12 288.02, 101.14 -55.26, -49.8 in-in in 9.031 Saltbr-in 2.578 HRD-in -76.71, -51.39 71.17, 0.36 in-out-out SNCioo out-out ActLoopNT-out 6.295 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.79, -16.26 APE9-dihe-na 71.23, -149.72 APE8-dihe-in -63.45, 121.67 APE8-rot-out 72.41 APE67-dihe-in -58.64, -26.17 -98.87, 3.1 APE12-dist-out 20.187 APE11-dist-out 20.45 APE10-dist-out 21.646 APE9-dist-out 28.253 T165E,S171E None None XRAY 1.69 0.194 0.219 B 309 289 0 0 0 0 [[17, 274]] 1.0 9czt Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9CZUA Q92918 5 293 833.0 A1A1D:402 Type1 Inactive DFGin 6.489 14.351 BLAminus -137.75, 175.2 60.15, 86.19 -93.64, 18.19 290.54, 89.04 -56.44, -52.47 in-in in 9.037 Saltbr-in 2.728 HRD-in -75.08, -47.99 65.32, -1.97 in-out-out SNCioo out-out ActLoopNT-out 6.362 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.17, -48.47 APE9-dihe-na 84.19, -157.27 APE8-dihe-in -72.64, 141.86 APE8-rot-out 43.34 APE67-dihe-in -57.98, -25.96 -98.31, -2.0 APE12-dist-out 20.226 APE11-dist-out 21.215 APE10-dist-out 21.689 APE9-dist-out 27.932 T165E,S171E None None XRAY 1.85 0.198 0.248 A 309 289 0 0 0 0 [[17, 274]] 1.0 9czu Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9CZUB Q92918 5 293 833.0 A1A1D:401 Type1 Inactive DFGin 6.627 14.256 BLAminus -142.58, 175.68 62.6, 83.65 -94.25, 18.74 283.17, 98.7 -57.67, -46.92 in-in in 8.941 Saltbr-in 2.711 HRD-in -79.54, -50.09 64.64, 8.44 in-out-out SNCioo out-out ActLoopNT-out 6.227 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -43.64, -23.49 APE9-dihe-na -83.63, -155.02 APE8-dihe-in -111.85, 117.82 APE8-rot-out 188.67 APE67-dihe-in -63.02, -29.49 -59.84, -30.8 APE12-dist-none 999.0 APE11-dist-out 21.237 APE10-dist-out 22.531 APE9-dist-out 27.303 T165E,S171E None None XRAY 1.85 0.198 0.248 B 309 281 8 0 0 3 [[17, 274]] 1.0 9czu Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9CZUC Q92918 2 293 833.0 A1A1D:401 Type1 Inactive DFGin 6.442 14.095 BLAminus -139.71, -179.22 60.34, 85.98 -94.91, 23.99 287.04, 94.1 -63.75, -52.11 in-in in 8.778 Saltbr-in 2.819 HRD-in -74.72, -51.25 65.43, 3.35 in-out-out SNCioo out-out ActLoopNT-out 6.098 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.95, -44.47 APE9-dihe-na 71.68, -170.18 APE8-dihe-in -74.3, 141.89 APE8-rot-out 51.45 APE67-dihe-in -58.88, -33.48 -102.84, 6.18 APE12-dist-out 19.796 APE11-dist-out 21.474 APE10-dist-out 22.33 APE9-dist-out 28.448 T165E,S171E None None XRAY 1.85 0.198 0.248 C 309 287 5 0 0 0 [[17, 274]] 1.0 9czu Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9CZUD Q92918 8 293 833.0 A1A1D:401 Type1 Inactive DFGin 6.537 14.124 BLAminus -133.54, 178.66 62.04, 84.09 -97.33, 23.34 283.9, 99.03 -63.9, -49.28 in-in in 8.641 Saltbr-in 2.812 HRD-in -74.93, -53.89 72.23, 2.08 in-out-out SNCioo out-out ActLoopNT-out 6.125 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -62.67, -39.85 APE9-dihe-na 75.44, -164.27 APE8-dihe-in -73.76, 140.22 APE8-rot-out 49.21 APE67-dihe-in -59.67, -27.82 -103.43, 3.8 APE12-dist-out 19.334 APE11-dist-out 20.71 APE10-dist-out 22.031 APE9-dist-out 28.546 T165E,S171E None None XRAY 1.85 0.198 0.248 D 309 282 4 0 0 0 [[17, 274]] 1.0 9czu Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9CZWA Q92918 5 292 833.0 A1A1C:401 Type1 Inactive DFGin 6.484 14.447 BLAminus -142.4, 176.37 61.0, 83.2 -91.86, 20.12 285.36, 100.06 -58.94, -45.03 in-in in 8.966 Saltbr-in 2.722 HRD-in -79.51, -49.76 66.53, 5.58 in-out-out SNCioo out-out ActLoopNT-out 6.181 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -76.64, -6.98 APE9-dihe-na 106.64, 178.38 APE8-dihe-in -78.01, 124.7 APE8-rot-in 294.47 APE67-dihe-in -59.5, -32.1 -67.37, -27.03 APE12-dist-out 21.065 APE11-dist-out 20.811 APE10-dist-out 20.554 APE9-dist-out 27.132 T165E,S171E None None XRAY 1.59 0.191 0.221 A 309 288 0 0 0 0 [[17, 274]] 1.0 9czw Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9CZWB Q92918 5 293 833.0 A1A1C:401 Type1 Inactive DFGin 6.281 14.195 BLAminus -145.03, 174.12 65.2, 80.3 -86.34, 20.99 291.56, 97.25 -57.8, -48.9 in-in in 9.065 Saltbr-in 2.581 HRD-in -78.76, -55.32 70.65, 5.05 in-out-out SNCioo out-out ActLoopNT-out 6.137 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.11, -8.45 APE9-dihe-na 103.65, 171.84 APE8-dihe-in -56.95, 141.18 APE8-rot-out 40.62 APE67-dihe-in -59.63, -31.73 -86.68, -21.16 APE12-dist-out 21.34 APE11-dist-out 20.851 APE10-dist-out 20.86 APE9-dist-out 27.494 T165E,S171E None None XRAY 1.59 0.191 0.221 B 309 289 0 0 0 0 [[17, 274]] 1.0 9czw Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9CZXA Q92918 1 292 833.0 A1A1B:60401 Type1 Inactive DFGin 5.456 14.116 BLAminus -136.88, 170.25 74.65, 86.4 -97.31, 23.38 288.29, 110.97 -60.88, -50.46 in-in in 9.02 Saltbr-in 2.721 HRD-in -77.07, -55.67 66.53, 5.39 in-out-out SNCioo out-out ActLoopNT-out 6.178 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.91, -29.12 APE9-dihe-na 72.57, -159.77 APE8-dihe-in -67.35, 141.44 APE8-rot-out 207.67 APE67-dihe-in -52.4, -31.07 -100.58, -15.44 APE12-dist-out 20.226 APE11-dist-out 20.5 APE10-dist-out 21.294 APE9-dist-out 27.598 T165E,S171E None None XRAY 1.464 0.216 0.242 A 309 288 4 0 0 0 [[17, 274]] 1.0 9czx Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9D00A Q92918 6 293 833.0 A1A1A:901 Type1 Inactive DFGin 6.336 14.447 BLAminus -140.17, 169.69 66.05, 82.16 -90.41, 19.67 289.69, 94.63 -57.9, -45.24 in-in in 9.147 Saltbr-in 2.544 HRD-in -69.4, -52.71 68.37, -0.38 in-out-out SNCioo out-out ActLoopNT-out 6.239 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -115.73, -16.53 APE9-dihe-na 70.33, -148.11 APE8-dihe-in -67.12, 125.31 APE8-rot-out 58.95 APE67-dihe-in -62.24, -23.42 -101.84, 10.31 APE12-dist-out 19.399 APE11-dist-out 20.636 APE10-dist-out 21.399 APE9-dist-out 28.194 None None None XRAY 1.951 0.247 0.279 A 309 284 4 0 0 0 [[17, 274]] 1.0 9d00 Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9D00B Q92918 4 292 833.0 A1A1A:401 Type1 Inactive DFGin 6.336 14.317 BLAminus -139.86, 169.35 66.73, 83.9 -91.21, 18.67 290.65, 95.0 -58.22, -46.78 in-in in 9.18 Saltbr-in 2.544 HRD-in -69.48, -53.11 69.59, -1.41 in-out-out SNCioo out-out ActLoopNT-out 6.19 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.7, -18.52 APE9-dihe-na 69.55, -149.8 APE8-dihe-in -76.21, 127.76 APE8-rot-out 54.96 APE67-dihe-in -61.76, -27.13 -102.55, 9.59 APE12-dist-out 19.308 APE11-dist-out 20.505 APE10-dist-out 21.513 APE9-dist-out 28.174 None None None XRAY 1.951 0.247 0.279 B 309 284 5 0 0 0 [[17, 274]] 1.0 9d00 Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9D00C Q92918 4 293 833.0 A1A1A:401 Type1 Inactive DFGin 6.242 14.447 BLAminus -140.24, 170.38 65.3, 82.76 -91.49, 20.02 291.46, 93.21 -59.78, -44.19 in-in in 9.119 Saltbr-in 2.57 HRD-in -70.48, -52.81 68.16, -0.69 in-out-out SNCioo out-out ActLoopNT-out 6.199 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -95.51, -17.94 APE9-dihe-na 66.33, -149.39 APE8-dihe-in -68.18, 126.44 APE8-rot-out 60.28 APE67-dihe-in -61.75, -26.6 -102.65, 9.42 APE12-dist-out 19.711 APE11-dist-out 20.098 APE10-dist-out 21.274 APE9-dist-out 28.024 None None None XRAY 1.951 0.247 0.279 C 309 284 6 0 0 0 [[17, 274]] 1.0 9d00 Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9D00D Q92918 4 292 833.0 A1A1A:401 Type1 Inactive DFGin 6.342 14.371 BLAminus -139.3, 170.77 65.41, 83.56 -92.51, 20.91 290.0, 94.21 -58.73, -44.95 in-in in 9.15 Saltbr-in 2.682 HRD-in -70.53, -51.9 66.76, -0.27 in-out-out SNCioo out-out ActLoopNT-out 6.168 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -82.51, -20.77 APE9-dihe-na 70.59, -152.77 APE8-dihe-in -74.62, 128.96 APE8-rot-out 53.71 APE67-dihe-in -61.19, -25.01 -101.63, 7.98 APE12-dist-out 19.416 APE11-dist-out 20.746 APE10-dist-out 21.537 APE9-dist-out 28.314 None None None XRAY 1.951 0.247 0.279 D 309 285 4 0 0 0 [[17, 274]] 1.0 9d00 Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9BIKB Q92918 4 293 833.0 A1APO:60306 Type1 Inactive DFGin 5.683 14.357 BLAminus -141.88, 171.96 69.55, 86.63 -96.36, 19.05 290.17, 117.22 -60.62, -46.28 in-out in 9.456 Saltbr-out 3.849 HRD-in -71.2, -54.39 71.44, 3.91 out-out-out SNCooo out-out ActLoopNT-out 6.194 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -83.12, -39.97 APE9-dihe-na 75.35, -114.91 APE8-dihe-in -113.34, 93.34 APE8-rot-out 58.64 APE67-dihe-in -71.32, -21.13 -98.03, 27.22 APE12-dist-out 20.218 APE11-dist-out 19.938 APE10-dist-out 22.034 APE9-dist-out 28.365 None None None XRAY 2.25 0.199 0.244 B 311 288 2 0 0 0 [[17, 274]] 1.0 9bik Homo sapiens STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9BJ1A Q92918 3 293 833.0 A1APR:60307 Type1 Inactive DFGin 6.569 14.529 BLAminus -146.0, -178.93 54.39, 80.26 -93.68, 26.78 292.39, 86.08 -69.21, -46.11 in-out in 9.572 Saltbr-out 5.495 HRD-in -81.77, -51.32 67.22, 6.16 out-out-out SNCooo out-out ActLoopNT-out 5.941 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.59, -26.74 APE9-dihe-na 73.54, -133.9 APE8-dihe-in -118.37, 92.73 APE8-rot-out 36.98 APE67-dihe-in -71.33, -19.35 -88.26, 22.61 APE12-dist-out 19.485 APE11-dist-out 20.488 APE10-dist-out 22.052 APE9-dist-out 28.312 None None None XRAY 2.18 0.176 0.228 A 311 291 0 0 0 0 [[17, 274]] 1.0 9bj1 Homo sapiens STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9NACA Q92918 3 293 833.0 A1BWM:60306 Type1 Inactive DFGin 6.288 14.967 BLAminus -143.28, -179.9 57.0, 78.75 -89.28, 19.43 296.28, 96.63 -61.6, -43.89 in-out in 9.294 Saltbr-out 3.664 HRD-in -70.18, -52.47 72.86, -0.69 out-out-out SNCooo out-out ActLoopNT-out 6.143 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -62.56, -29.04 APE9-dihe-na 78.31, -171.8 APE8-dihe-in -65.01, 137.86 APE8-rot-out 193.85 APE67-dihe-in -68.58, -21.98 -102.03, 0.3 APE12-dist-out 19.421 APE11-dist-out 20.936 APE10-dist-out 21.655 APE9-dist-out 27.942 None None None XRAY 1.45 0.178 0.193 A 311 291 0 0 0 0 [[17, 274]] 1.0 9nac Homo sapiens STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9NACB Q92918 5 293 833.0 A1BWM:60312 Type1 Inactive DFGin 6.317 14.872 BLAminus -141.68, 174.58 62.05, 80.76 -88.85, 23.58 293.45, 94.02 -62.42, -47.37 in-out in 9.662 Saltbr-out 4.157 HRD-in -72.47, -48.21 72.81, -1.94 out-out-out SNCooo out-out ActLoopNT-out 6.322 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.0 APE8-rot-out 87.18 APE67-dihe-in -67.23, -23.72 -101.81, -5.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.45 0.178 0.193 B 311 285 4 0 0 4 [[17, 274]] 1.0 9nac Homo sapiens STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9NBSA Q92918 3 293 833.0 A1BW4:312 Type1 Inactive DFGin 6.543 15.139 BLAminus -146.1, 166.61 69.7, 85.0 -90.14, 23.76 293.67, 93.84 -61.08, -43.36 out-out out 10.091 Saltbr-out 4.649 HRD-in -75.52, -51.94 71.79, 2.7 out-out-out SNCooo out-out ActLoopNT-out 6.275 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -64.95, -30.13 APE9-dihe-na 83.5, -176.39 APE8-dihe-in -60.89, 134.02 APE8-rot-out 196.75 APE67-dihe-in -67.54, -23.89 -100.39, -0.26 APE12-dist-out 19.234 APE11-dist-out 20.805 APE10-dist-out 21.589 APE9-dist-out 27.824 None None None XRAY 1.8 0.167 0.207 A 311 291 0 0 0 0 [[17, 274]] 1.0 9nbs Homo sapiens STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9NBSB Q92918 4 293 833.0 A1BW4:309 Type1 Inactive DFGin 6.679 15.424 BLAminus -142.94, 164.96 71.95, 83.55 -93.82, 22.6 293.89, 95.45 -62.36, -42.17 out-out out 10.076 Saltbr-out 3.712 HRD-in -71.82, -53.88 74.04, 5.26 out-out-out SNCooo out-out ActLoopNT-out 6.126 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.84, -27.25 APE9-dihe-na 80.94, -173.11 APE8-dihe-in -65.61, 141.02 APE8-rot-out 195.95 APE67-dihe-in -67.9, -21.76 -102.86, -1.4 APE12-dist-out 19.216 APE11-dist-out 20.977 APE10-dist-out 21.623 APE9-dist-out 27.685 None None None XRAY 1.8 0.167 0.207 B 311 290 0 0 0 0 [[17, 274]] 1.0 9nbs Homo sapiens STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9NC2A Q92918 3 292 833.0 F97:301 Type1 Inactive DFGin 6.169 14.56 BLAminus -146.03, -172.66 54.61, 75.11 -87.07, 18.0 287.4, 99.86 -60.8, -42.16 in-in in 9.077 Saltbr-in 3.084 HRD-in -71.62, -49.35 69.24, 2.43 in-out-out SNCioo out-out ActLoopNT-out 6.365 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.88, -25.86 APE9-dihe-na 79.92, -176.93 APE8-dihe-in -63.28, 137.33 APE8-rot-out 195.9 APE67-dihe-in -69.31, -23.4 -99.38, -2.77 APE12-dist-out 19.365 APE11-dist-out 20.869 APE10-dist-out 21.697 APE9-dist-out 27.663 T165E,S171E None None XRAY 1.5 0.159 0.182 A 311 290 0 0 0 0 [[17, 274]] 1.0 9nc2 Homo sapiens STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9NC2B Q92918 4 293 833.0 F97:301 Type1 Inactive DFGin 6.219 15.322 BLAminus -146.56, -178.89 56.97, 76.11 -90.84, 22.27 287.71, 91.06 -63.05, -41.66 in-out in 9.74 Saltbr-out 4.08 HRD-in -71.95, -49.68 67.73, 5.0 out-out-out SNCooo out-out ActLoopNT-out 6.107 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -65.85, -26.59 APE9-dihe-na 76.68, -178.01 APE8-dihe-in -63.02, 140.61 APE8-rot-out 197.6 APE67-dihe-in -68.97, -20.58 -101.56, -1.68 APE12-dist-out 19.288 APE11-dist-out 20.819 APE10-dist-out 21.719 APE9-dist-out 27.484 T165E,S171E None None XRAY 1.5 0.159 0.182 B 311 283 7 0 0 0 [[17, 274]] 1.0 9nc2 Homo sapiens STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8FH4A Q92918 4 293 833.0 XXF:60401 Type1 Inactive DFGin 6.846 14.475 BLAminus -131.99, 171.23 62.34, 86.7 -92.12, 20.1 289.3, 88.42 -59.7, -48.05 in-in in 9.232 Saltbr-in 2.734 HRD-in -67.47, -51.18 67.4, 4.94 in-out-out SNCioo out-out ActLoopNT-out 6.199 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.65, -44.57 APE9-dihe-na 76.29, -171.23 APE8-dihe-in -62.48, 141.12 APE8-rot-out 34.25 APE67-dihe-in -59.58, -27.68 -102.29, 0.49 APE12-dist-out 20.304 APE11-dist-out 21.079 APE10-dist-out 21.421 APE9-dist-out 27.259 T165E,S171E None None XRAY 1.827 0.189 0.215 A 331 290 0 0 0 0 [[17, 274]] 1.0 8fh4 Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8FH4B Q92918 6 302 833.0 XXF:60402 Type1 Inactive DFGin 6.551 14.294 BLAminus -141.43, 174.43 62.64, 85.33 -93.2, 13.55 285.99, 85.49 -57.34, -45.75 in-in in 8.939 Saltbr-in 2.697 HRD-in -67.85, -50.88 67.73, 2.48 in-out-out SNCioo out-out ActLoopNT-out 6.309 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.39, -32.57 APE9-dihe-na 75.42, -167.37 APE8-dihe-in -61.44, 126.8 APE8-rot-out 59.49 APE67-dihe-in -56.24, -30.95 -97.05, -0.91 APE12-dist-out 19.464 APE11-dist-out 20.586 APE10-dist-out 21.665 APE9-dist-out 28.047 T165E,S171E None None XRAY 1.827 0.189 0.215 B 331 297 0 0 0 0 [[17, 274]] 1.0 8fh4 Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8FH4C Q92918 1 292 833.0 XXF:60401 Type1 Inactive DFGin 6.824 14.118 BLAminus -136.31, 172.65 64.01, 85.1 -95.02, 19.77 288.84, 83.7 -61.21, -46.39 in-in in 8.967 Saltbr-in 2.733 HRD-in -69.91, -50.19 67.9, 0.86 in-out-out SNCioo out-out ActLoopNT-out 6.08 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.7, -68.85 APE9-dihe-na -109.26, -27.15 APE8-dihe-in -115.11, 101.44 APE8-rot-out 62.11 APE67-dihe-in -65.51, -20.35 -96.81, 16.0 APE12-dist-out 19.318 APE11-dist-out 20.935 APE10-dist-out 23.085 APE9-dist-out 28.365 T165E,S171E None None XRAY 1.827 0.189 0.215 C 331 292 0 0 0 0 [[17, 274]] 1.0 8fh4 Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8FH4D Q92918 8 292 833.0 XXF:60401 Type1 Inactive DFGin 6.646 14.023 BLAminus -135.73, 170.9 66.66, 83.46 -93.58, 25.1 289.61, 94.72 -69.05, -41.66 in-in in 9.022 Saltbr-in 2.745 HRD-in -74.6, -51.27 71.89, -5.96 in-out-out SNCioo out-out ActLoopNT-out 6.134 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.02 APE8-dihe-in -67.05, 131.5 APE8-rot-out 192.16 APE67-dihe-in -57.98, -30.82 -102.78, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 27.427 T165E,S171E None None XRAY 1.827 0.189 0.215 D 331 276 9 0 0 4 [[17, 274]] 1.0 8fh4 Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8FJZA Q92918 3 292 833.0 Y3I:401 Type1 Inactive DFGin 6.51 14.504 BLAminus -137.7, 170.08 62.89, 84.84 -92.48, 16.46 289.48, 97.05 -57.69, -48.7 in-in in 9.024 Saltbr-in 2.853 HRD-in -76.6, -50.02 65.48, 5.07 in-out-out SNCioo out-out ActLoopNT-out 6.147 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.77, -28.54 APE9-dihe-na 83.8, -160.52 APE8-dihe-in -69.85, 130.12 APE8-rot-out 203.17 APE67-dihe-in -57.6, -27.08 -102.15, -1.9 APE12-dist-out 19.688 APE11-dist-out 20.668 APE10-dist-out 21.671 APE9-dist-out 28.13 T165E,S171E None None XRAY 1.897 0.216 0.249 A 331 288 2 0 0 0 [[17, 274]] 1.0 8fjz Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8FJZB Q92918 5 292 833.0 Y3I:401 Type1 Inactive DFGin 6.57 14.021 BLAminus -137.02, 169.84 67.81, 83.93 -94.03, 22.71 289.99, 87.03 -64.87, -48.53 in-in in 8.905 Saltbr-in 2.675 HRD-in -75.0, -51.65 69.43, 3.22 in-out-out SNCioo out-out ActLoopNT-out 5.948 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 126.69 APE8-rot-out 63.83 APE67-dihe-in -54.59, -38.97 -101.21, 8.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T165E,S171E None None XRAY 1.897 0.216 0.249 B 331 284 4 0 0 4 [[17, 274]] 1.0 8fjz Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8FJZC Q92918 5 292 833.0 Y3I:401 Type1 Inactive DFGin 6.587 14.237 BLAminus -130.95, 168.73 65.84, 84.49 -90.64, 23.57 288.05, 96.05 -64.63, -46.84 in-in in 8.898 Saltbr-in 2.7 HRD-in -82.44, -52.09 67.55, 1.71 in-out-out SNCioo out-out ActLoopNT-out 6.231 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -63.71, -26.25 APE9-dihe-na 76.16, -172.12 APE8-dihe-in -60.33, 130.84 APE8-rot-out 195.91 APE67-dihe-in -63.98, -25.54 -102.76, 2.25 APE12-dist-out 19.401 APE11-dist-out 20.592 APE10-dist-out 21.738 APE9-dist-out 28.12 T165E,S171E None None XRAY 1.897 0.216 0.249 C 331 288 0 0 0 0 [[17, 274]] 1.0 8fjz Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8FJZD Q92918 5 292 833.0 Y3I:401 Type1 Inactive DFGin 6.717 14.041 BLAminus -137.08, 171.73 59.36, 82.37 -86.27, 18.66 292.08, 95.93 -58.09, -54.94 in-in in 8.988 Saltbr-in 2.732 HRD-in -69.09, -53.22 71.65, -0.73 in-out-out SNCioo out-out ActLoopNT-out 6.095 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -148.42 APE8-dihe-in -68.43, 138.08 APE8-rot-out 39.71 APE67-dihe-in -52.93, -33.25 -97.78, -5.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.327 T165E,S171E None None XRAY 1.897 0.216 0.249 D 331 279 9 0 0 5 [[17, 274]] 1.0 8fjz Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8FJZE Q92918 6 292 833.0 Y3I:401 Type1 Inactive DFGin 6.774 14.099 BLAminus -136.75, 169.37 68.25, 86.68 -95.74, 24.36 294.3, 85.62 -65.14, -47.45 in-in in 8.919 Saltbr-in 2.724 HRD-in -74.26, -49.77 67.78, 3.39 in-out-out SNCioo out-out ActLoopNT-out 6.066 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -56.26, -48.49 APE9-dihe-na 80.16, 179.63 APE8-dihe-in -54.87, 130.2 APE8-rot-in 306.01 APE67-dihe-in -57.58, -32.37 -99.48, -10.41 APE12-dist-out 19.306 APE11-dist-out 20.62 APE10-dist-out 22.177 APE9-dist-out 28.139 T165E,S171E None None XRAY 1.897 0.216 0.249 E 331 283 4 0 0 0 [[17, 274]] 1.0 8fjz Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8FJZF Q92918 9 292 833.0 Y3I:401 Type1 Inactive DFGin 6.754 14.514 BLAminus -131.7, 172.77 61.74, 84.47 -90.86, 22.68 286.38, 91.5 -60.13, -49.97 in-in in 9.121 Saltbr-in 2.741 HRD-in -74.14, -51.77 66.66, 4.96 in-out-out SNCioo out-out ActLoopNT-out 5.986 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -63.64, -30.73 APE9-dihe-na 73.64, -165.36 APE8-dihe-in -58.14, 130.21 APE8-rot-out 197.86 APE67-dihe-in -59.67, -30.33 -96.67, -2.31 APE12-dist-out 19.267 APE11-dist-out 20.726 APE10-dist-out 21.359 APE9-dist-out 27.978 T165E,S171E None None XRAY 1.897 0.216 0.249 F 331 276 8 0 0 0 [[17, 274]] 1.0 8fjz Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8FKOA Q92918 4 292 833.0 Y3O:401 Type1 Inactive DFGin 6.6 14.474 BLAminus -136.74, 175.6 60.99, 80.38 -90.69, 19.24 290.65, 92.45 -58.8, -50.56 in-in in 9.008 Saltbr-in 2.865 HRD-in -73.32, -49.99 68.3, 0.65 in-out-out SNCioo out-out ActLoopNT-out 6.173 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -69.21, -28.97 APE9-dihe-na 81.7, -165.26 APE8-dihe-in -68.43, 130.79 APE8-rot-out 206.57 APE67-dihe-in -61.7, -26.02 -104.74, 4.48 APE12-dist-out 19.399 APE11-dist-out 20.778 APE10-dist-out 21.72 APE9-dist-out 28.14 T165E,S171E None None XRAY 2.104 0.222 0.258 A 331 289 0 0 0 0 [[17, 274]] 1.0 8fko Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8FKOB Q92918 5 292 833.0 Y3O:401 Type1 Inactive DFGin 6.742 14.362 BLAminus -132.05, 170.07 64.75, 88.13 -97.12, 25.5 288.76, 98.36 -61.57, -55.4 in-in in 9.414 Saltbr-in 2.741 HRD-in -70.11, -54.58 72.79, -2.56 in-out-out SNCioo out-out ActLoopNT-out 5.828 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 135.87 APE8-rot-out 50.22 APE67-dihe-in -58.48, -31.01 -101.42, 4.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T165E,S171E None None XRAY 2.104 0.222 0.258 B 331 281 7 0 0 7 [[17, 274]] 1.0 8fko Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8FKOC Q92918 5 292 833.0 Y3O:401 Type1 Inactive DFGin 6.775 14.419 BLAminus -132.55, 171.23 64.29, 81.94 -88.9, 26.84 288.08, 99.44 -65.27, -52.46 in-in in 8.665 Saltbr-in 2.911 HRD-in -74.45, -54.73 70.38, 2.95 in-out-out SNCioo out-out ActLoopNT-out 6.228 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.61, -32.11 APE9-dihe-na 79.88, -174.37 APE8-dihe-in -60.81, 133.78 APE8-rot-out 52.53 APE67-dihe-in -64.71, -25.08 -101.63, 4.73 APE12-dist-out 19.479 APE11-dist-out 20.54 APE10-dist-out 21.92 APE9-dist-out 28.333 T165E,S171E None None XRAY 2.104 0.222 0.258 C 331 288 0 0 0 0 [[17, 274]] 1.0 8fko Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8FKOD Q92918 5 292 833.0 Y3O:401 Type1 Inactive DFGin 6.709 14.678 BLAminus -131.09, 178.78 56.35, 80.98 -89.1, 26.55 286.22, 90.67 -64.13, -49.82 in-in in 8.965 Saltbr-in 2.747 HRD-in -66.34, -52.49 71.26, -7.01 in-out-out SNCioo out-out ActLoopNT-out 6.206 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -158.42 APE8-dihe-in -63.3, 145.09 APE8-rot-out 69.9 APE67-dihe-in -64.17, -28.12 -107.51, 10.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.25 T165E,S171E None None XRAY 2.104 0.222 0.258 D 331 279 9 0 0 5 [[17, 274]] 1.0 8fko Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8FKOE Q92918 9 292 833.0 Y3O:401 Type1 Inactive DFGin 6.435 14.085 BLAminus -135.28, 164.55 67.79, 89.79 -102.78, 38.26 298.04, 85.81 -76.64, -45.96 in-in in 8.677 Saltbr-in 2.736 HRD-in -62.44, -55.25 72.64, 2.07 in-out-out SNCioo out-out ActLoopNT-out 6.141 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -58.79, -42.45 APE9-dihe-na 75.19, -172.93 APE8-dihe-in -61.39, 128.93 APE8-rot-in 302.43 APE67-dihe-in -54.75, -33.19 -95.27, -10.5 APE12-dist-out 19.343 APE11-dist-out 20.455 APE10-dist-out 21.955 APE9-dist-out 28.115 T165E,S171E None None XRAY 2.104 0.222 0.258 E 331 271 13 0 0 0 [[17, 274]] 1.0 8fko Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7L24A Q92918 7 293 833.0 XHV:301 Type1 Inactive DFGin 7.009 14.62 BLAminus -143.84, -179.7 61.55, 69.1 -91.94, 12.61 283.35, 87.89 -58.65, -41.1 in-in in 8.865 Saltbr-in 3.018 HRD-in -76.34, -55.95 67.89, 13.07 in-out-out SNCioo out-out ActLoopNT-out 6.039 ActLoopCT-out nonTYR APEdihe_aannn APEdist_onnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -83.54, -38.3 999.0, -31.75 APE12-dist-out 21.759 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S171A,G191C None None XRAY 2.68 0.227 0.272 A 288 283 4 0 0 4 [[17, 274]] 1.0 7l24 Homo sapiens STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7L24B Q92918 7 293 833.0 XHV:301 Type1 Inactive DFGin 6.546 13.975 BLAminus -135.14, 169.97 71.4, 79.39 -97.76, 12.38 287.4, 86.62 -58.33, -41.41 in-in in 8.914 Saltbr-in 2.438 HRD-in -76.97, -54.35 69.63, 6.66 in-out-out SNCioo out-out ActLoopNT-out 5.569 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 128.53 APE9-dihe-na -79.83, -176.62 APE8-dihe-in -81.98, 123.97 APE8-rot-in 295.15 APE67-dihe-in -69.95, -26.85 -67.53, -22.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 22.945 APE9-dist-out 27.304 S171A,G191C None None XRAY 2.68 0.227 0.272 B 288 271 16 0 0 11 [[17, 274]] 1.0 7l24 Homo sapiens STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7L24C Q92918 8 293 833.0 XHV:301 Type1 Inactive DFGin 6.624 13.96 BLAminus -136.48, 171.4 72.39, 79.87 -99.38, 13.47 287.36, 81.53 -59.93, -44.55 in-in in 9.034 Saltbr-in 3.127 HRD-in -75.35, -55.81 67.71, 14.86 in-out-out SNCioo out-out ActLoopNT-out 5.741 ActLoopCT-out nonTYR APEdihe_aanii APEdist_ooon APE10-dihe-na -156.45, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 105.18 APE8-rot-in 294.61 APE67-dihe-in -70.16, -27.48 -121.22, 17.23 APE12-dist-out 19.985 APE11-dist-out 20.145 APE10-dist-out 21.577 APE9-dist-none 999.0 S171A,G191C None None XRAY 2.68 0.227 0.272 C 288 283 3 0 0 3 [[17, 274]] 1.0 7l24 Homo sapiens STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7L24D Q92918 8 292 833.0 XHV:301 Type1 Inactive DFGin 6.968 14.326 BLAminus -134.37, 175.58 63.92, 76.15 -95.35, 10.89 286.09, 85.69 -58.43, -42.03 in-in in 8.952 Saltbr-in 3.364 HRD-in -77.33, -58.31 72.58, 6.78 in-out-out SNCioo out-out ActLoopNT-out 5.813 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -101.26, -46.51 APE9-dihe-na 81.9, 171.61 APE8-dihe-in -50.17, 142.46 APE8-rot-out 55.63 APE67-dihe-in -69.03, -27.01 -120.49, 22.45 APE12-dist-out 19.237 APE11-dist-out 21.048 APE10-dist-out 21.272 APE9-dist-out 27.624 S171A,G191C None None XRAY 2.68 0.227 0.272 D 288 274 11 0 0 0 [[17, 274]] 1.0 7l24 Homo sapiens STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9CZXB Q92918 8 292 833.0 A1A1B:60402,A1A1B:60403 Type1,Allosteric Inactive DFGin 6.343 14.279 BLAminus -134.7, 170.43 71.89, 82.48 -96.36, 23.25 289.39, 99.86 -63.19, -37.33 in-in in 9.036 Saltbr-in 2.712 HRD-in -68.81, -50.24 70.2, 0.87 in-out-out SNCioo out-out ActLoopNT-out 5.927 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.69, 123.51 APE9-dihe-na -83.33, -140.23 APE8-dihe-in -74.52, 137.21 APE8-rot-out 68.09 APE67-dihe-in -59.39, -33.85 -97.6, 2.5 APE12-dist-out 20.309 APE11-dist-out 20.831 APE10-dist-out 22.527 APE9-dist-out 28.487 T165E,S171E None None XRAY 1.464 0.216 0.242 B 309 285 0 0 0 0 [[17, 274]] 1.0 9czx Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9BJ1B Q92918 5 293 833.0 A1APQ:60307 Type1.5_Back Inactive DFGin 7.037 13.81 BLAminus -140.55, 172.82 64.02, 87.63 -97.29, 21.1 289.69, 88.26 -60.45, -45.75 in-in in 8.872 Saltbr-in 2.732 HRD-in -88.62, -54.15 69.86, 7.97 in-out-out SNCioo out-out ActLoopNT-out 6.1 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -85.03, -20.64 APE9-dihe-na 69.49, -145.44 APE8-dihe-in -88.44, 115.74 APE8-rot-out 46.21 APE67-dihe-in -65.1, -22.62 -98.35, 16.87 APE12-dist-out 19.307 APE11-dist-out 20.333 APE10-dist-out 21.769 APE9-dist-out 28.153 None None None XRAY 2.18 0.176 0.228 B 311 289 0 0 0 0 [[17, 274]] 1.0 9bj1 Homo sapiens STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7KACA Q92918 7 304 833.0 W9D:401 Type1 Inactive DFGin 8.022 14.805 None -141.48, 167.09 66.93, 78.4 -88.8, 999.0 297.14, 96.79 999.0, 999.0 out-out out 12.754 Saltbr-out 11.254 HRD-in -70.03, -49.57 71.67, 0.31 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -89.52, 94.35 APE9-dihe-na 120.85, -175.69 APE8-dihe-in -107.35, 147.06 APE8-rot-out 190.1 APE67-dihe-in -53.56, -32.93 -92.41, -14.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 26.986 L221D,F225E None None XRAY 1.85 0.217 0.232 A 340 283 15 0 0 15 [[17, 274]] 1.0 7kac Homo sapiens STE_MAP4K1_HUMAN STE 4.2e-91 310.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9H8DA Q92918 7 293 833.0 A1ITC:301 Type1 Inactive DFGin 4.623 14.038 None -56.45, -37.26 -153.97, -176.48 -89.45, 20.13 56.87, 83.02 106.24, -162.07 out-out out 13.393 Saltbr-out 11.411 HRD-in -65.3, -52.29 59.62, 17.42 out-out-out SNCooo out-out ActLoopNT-out 6.941 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -60.47, -36.02 APE9-dihe-na -87.07, -11.18 APE8-dihe-in -151.76, 75.87 APE8-rot-out 169.0 APE67-dihe-in -55.43, -30.79 -91.48, 7.95 APE12-dist-in 9.289 APE11-dist-in 10.207 APE10-dist-out 13.999 APE9-dist-out 12.455 T165E,S171E None None XRAY 1.641 0.199 0.226 A 294 287 0 0 0 0 [[17, 274]] 1.0 9h8d Homo sapiens STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9H8EA Q92918 7 293 833.0 A1ITA:301 Type1 Inactive DFGin 4.871 13.643 None -54.93, -36.87 -153.52, -178.14 -86.71, 13.52 57.7, 54.93 110.72, -162.78 out-out out 13.244 Saltbr-out 11.94 HRD-in -64.82, -60.03 68.16, 15.68 out-out-out SNCooo out-out ActLoopNT-out 7.428 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -56.89, -34.7 APE9-dihe-na -89.78, -12.26 APE8-dihe-in -151.93, 70.96 APE8-rot-out 171.34 APE67-dihe-in -55.35, -30.86 -85.9, 6.53 APE12-dist-in 9.316 APE11-dist-in 10.439 APE10-dist-out 14.104 APE9-dist-out 12.387 T165E,S171E None None XRAY 1.631 0.195 0.218 A 294 287 0 0 0 0 [[17, 274]] 1.0 9h8e Homo sapiens STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9H8FA Q92918 7 293 833.0 A1ITB:301 Type1 Inactive DFGin 4.705 13.378 None -52.93, -40.35 -154.71, -177.86 -83.04, 10.74 51.93, 61.71 106.06, -156.77 out-out out 13.504 Saltbr-out 12.054 HRD-in -67.59, -55.04 63.7, 17.96 out-out-out SNCooo out-out ActLoopNT-out 7.349 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -58.32, -34.33 APE9-dihe-na -89.38, -1.89 APE8-dihe-in -161.32, 73.17 APE8-rot-out 170.41 APE67-dihe-in -57.59, -27.85 -94.08, 8.2 APE12-dist-in 9.175 APE11-dist-in 10.305 APE10-dist-out 14.04 APE9-dist-out 12.303 T165E,S171E None None XRAY 1.393 0.203 0.246 A 294 287 0 0 0 0 [[17, 274]] 1.0 9h8f Homo sapiens STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9QT6A Q92918 6 292 833.0 A1JAF:301 Type1 Inactive DFGin 6.463 13.765 None -60.93, -35.58 -154.04, -176.9 -79.86, 1.42 63.88, 19.01 105.02, -157.57 out-out out 13.28 Saltbr-out 10.782 HRD-in -74.09, -55.53 70.27, 5.38 out-out-out SNCooo out-out ActLoopNT-out 7.582 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -59.89, -40.77 APE9-dihe-na -92.18, -16.28 APE8-dihe-in -142.86, 74.69 APE8-rot-in 316.27 APE67-dihe-in -56.11, -27.62 -91.41, -1.8 APE12-dist-in 9.809 APE11-dist-in 11.134 APE10-dist-out 15.153 APE9-dist-out 12.698 T165E,S171E None None XRAY 1.76 0.198 0.226 A 294 285 2 0 0 0 [[17, 274]] 1.0 9qt6 Homo sapiens STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 6NG0A Q92918 6 302 833.0 B49:9000 Type1 Inactive DFGin 5.141 15.065 None -69.74, 172.09 -58.45, 155.47 -142.74, 154.55 54.54, 93.56 67.99, -7.56 out-out out 12.858 Saltbr-out 10.815 HRD-in -63.9, -48.24 77.74, -8.02 out-out-out SNCooo out-out ActLoopNT-out 10.601 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -51.88, -33.41 APE9-dihe-na -72.94, -17.4 APE8-dihe-in -134.99, 76.22 APE8-rot-in 306.88 APE67-dihe-in -54.91, -28.64 -97.55, -2.9 APE12-dist-out 23.075 APE11-dist-out 25.012 APE10-dist-out 24.594 APE9-dist-out 28.735 T165E,S171E None None XRAY 2.05 0.202 0.229 A 309 289 8 0 0 5 [[17, 274]] 1.0 6ng0 Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 6CQFA Q92918 6 293 833.0 F97:301 Type1 Inactive DFGin 4.938 15.018 None -68.84, 171.73 -65.96, 157.38 -148.76, 145.95 51.62, 92.75 82.89, -6.34 out-out out 12.948 Saltbr-out 11.471 HRD-in -70.81, -45.95 79.09, -18.39 out-out-out SNCooo out-out ActLoopNT-out 10.287 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na 52.73, 67.51 APE9-dihe-na 130.19, -174.52 APE8-dihe-in -127.23, 115.01 APE8-rot-in 316.68 APE67-dihe-in -61.16, -24.43 -41.69, -51.15 APE12-dist-out 15.318 APE11-dist-out 16.648 APE10-dist-out 20.688 APE9-dist-out 21.386 None None None XRAY 2.246 0.21 0.255 A 297 282 6 0 0 6 [[17, 274]] 1.0 6cqf Homo sapiens STE_MAP4K1_HUMAN STE 4e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7R9LA Q92918 7 293 833.0 2YE:60301 Type1 Inactive DFGin 5.371 15.871 None -79.3, 179.17 -65.19, 145.46 -137.47, 150.51 63.11, 101.31 78.13, -24.94 out-out out 13.256 Saltbr-out 11.156 HRD-in -72.62, -38.36 76.08, -17.52 out-out-out SNCooo out-out ActLoopNT-out 9.297 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -49.77 APE9-dihe-na 168.11, -141.43 APE8-dihe-in -134.99, 123.61 APE8-rot-in 309.2 APE67-dihe-in -71.83, -29.15 -51.51, -37.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.951 APE9-dist-out 20.567 None None None XRAY 2.332 0.23 0.284 A 297 281 6 0 0 6 [[17, 274]] 1.0 7r9l Homo sapiens STE_MAP4K1_HUMAN STE 4e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7L26A Q92918 8 294 833.0 XHM:301 Type1 Inactive DFGin 5.165 15.699 None -90.65, 167.41 -51.45, 151.26 -138.89, 999.0 46.52, 93.57 999.0, 999.0 out-out out 13.649 Saltbr-out 12.266 HRD-in -70.63, -54.99 86.79, -28.34 out-out-out SNCooo out-out ActLoopNT-out 11.408 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -80.69, -41.73 APE9-dihe-na 172.07, -144.25 APE8-dihe-in -123.38, 126.59 APE8-rot-in 309.45 APE67-dihe-in -64.56, -28.61 -52.67, -44.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.76 S171A,G191C None None XRAY 2.3 0.263 0.298 A 287 280 7 0 0 3 [[17, 274]] 1.0 7l26 Homo sapiens STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7L26B Q92918 8 294 833.0 XHM:301 Type1 Inactive DFGin 5.053 15.91 None -91.19, 163.6 -51.51, 146.14 -129.86, 999.0 50.48, 91.75 999.0, 999.0 out-out out 13.395 Saltbr-out 10.525 HRD-in -70.31, -53.37 86.88, -29.66 out-out-out SNCooo out-out ActLoopNT-out 11.643 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, -41.02 APE9-dihe-na -160.51, -140.31 APE8-dihe-in -120.3, 127.28 APE8-rot-in 312.21 APE67-dihe-in -60.79, -31.57 -54.68, -45.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.977 S171A,G191C None None XRAY 2.3 0.263 0.298 B 287 275 12 0 0 7 [[17, 274]] 1.0 7l26 Homo sapiens STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7L26C Q92918 8 294 833.0 XHM:301 Type1 Inactive DFGin 5.239 15.713 None -90.03, 164.23 -51.57, 154.12 -136.67, 999.0 47.02, 92.8 999.0, 999.0 out-out out 13.519 Saltbr-out 12.211 HRD-in -69.66, -55.84 84.96, -26.68 out-out-out SNCooo out-out ActLoopNT-out 11.356 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -82.36, -41.22 APE9-dihe-na 172.52, -152.31 APE8-dihe-in -119.13, 126.23 APE8-rot-in 306.88 APE67-dihe-in -64.39, -28.24 -51.56, -46.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.638 S171A,G191C None None XRAY 2.3 0.263 0.298 C 287 280 7 0 0 3 [[17, 274]] 1.0 7l26 Homo sapiens STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7L26D Q92918 8 294 833.0 XHM:301 Type1 Inactive DFGin 5.178 15.724 None -92.34, 166.71 -52.02, 146.05 -132.39, 999.0 51.2, 93.07 999.0, 999.0 out-out out 13.064 Saltbr-out 11.471 HRD-in -69.0, -53.47 85.02, -28.41 out-out-out SNCooo out-out ActLoopNT-out 10.874 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -61.1, -36.36 APE9-dihe-na -126.65, -143.86 APE8-dihe-in -116.21, 125.85 APE8-rot-in 315.3 APE67-dihe-in -62.16, -30.12 -53.98, -45.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.683 S171A,G191C None None XRAY 2.3 0.263 0.298 D 287 275 12 0 0 7 [[17, 274]] 1.0 7l26 Homo sapiens STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7L25A Q92918 7 294 833.0 XHS:301 Type1 Inactive DFGin 4.883 15.036 None -55.28, -37.86 -159.35, -176.67 -80.39, 10.23 63.68, 79.5 109.4, -154.39 out-out out 13.357 Saltbr-out 10.987 HRD-in -68.56, -54.21 74.19, 0.12 out-out-out SNCooo out-out ActLoopNT-out 6.93 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -67.83, -24.29 APE9-dihe-na 79.98, -160.78 APE8-dihe-in -62.61, 131.99 APE8-rot-out 193.6 APE67-dihe-in -64.53, -27.32 -96.3, 1.86 APE12-dist-in 12.785 APE11-dist-in 12.327 APE10-dist-out 11.319 APE9-dist-out 9.214 S171A,G191C None None XRAY 1.85 0.187 0.227 A 289 288 0 0 0 0 [[17, 274]] 1.0 7l25 Homo sapiens STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7L25B Q92918 6 293 833.0 XHS:301 Type1 Inactive DFGin 4.692 15.194 None -55.03, -37.48 -157.98, -176.29 -82.32, 12.4 61.67, 77.66 107.44, -152.88 out-out out 14.055 Saltbr-out 11.455 HRD-in -67.3, -54.15 74.75, -2.09 out-out-out SNCooo out-out ActLoopNT-out 6.939 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -67.95, -23.75 APE9-dihe-na 79.88, -158.91 APE8-dihe-in -63.36, 133.86 APE8-rot-out 194.95 APE67-dihe-in -65.2, -27.32 -96.05, 0.4 APE12-dist-in 12.75 APE11-dist-in 12.198 APE10-dist-out 11.462 APE9-dist-out 9.201 S171A,G191C None None XRAY 1.85 0.187 0.227 B 289 288 0 0 0 0 [[17, 274]] 1.0 7l25 Homo sapiens STE_MAP4K1_HUMAN STE 1.5e-91 312.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7SIUA Q92918 5 294 833.0 9ID:60901 Type1.5_Back Inactive DFGin 3.837 13.895 None -51.62, -38.18 -156.43, -174.28 -96.36, 21.52 50.92, 94.98 81.37, -133.4 out-out out 13.418 Saltbr-out 9.847 HRD-in -75.88, -56.67 70.34, 5.7 out-out-out SNCooo out-out ActLoopNT-out 6.983 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -60.93, -38.93 APE9-dihe-na 77.72, -173.74 APE8-dihe-in -55.84, 129.92 APE8-rot-out 190.44 APE67-dihe-in -64.04, -19.87 -98.67, -1.07 APE12-dist-out 14.742 APE11-dist-in 11.943 APE10-dist-out 11.923 APE9-dist-out 18.051 None None None XRAY 1.786 0.187 0.205 A 310 290 0 0 0 0 [[17, 274]] 1.0 7siu Homo sapiens STE_MAP4K1_HUMAN STE 4e-91 310.9 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7SIUB Q92918 16 294 833.0 9ID:60301 Type1.5_Back Inactive DFGin 5.076 13.483 None -53.44, -36.92 -155.11, -179.05 -87.99, 18.37 47.54, 74.7 106.16, -161.65 out-out out 12.383 Saltbr-out 8.79 HRD-in -71.24, -52.8 63.02, 13.42 out-out-out SNCooo out-out ActLoopNT-out 7.165 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -100.2, -45.71 APE9-dihe-na 128.51, -162.4 APE8-dihe-in -63.73, 151.22 APE8-rot-out 52.58 APE67-dihe-in -59.58, -25.5 -100.41, 4.16 APE12-dist-out 16.955 APE11-dist-out 16.612 APE10-dist-out 17.1 APE9-dist-out 21.748 None None None XRAY 1.786 0.187 0.205 B 310 279 0 0 0 0 [[17, 274]] 1.0 7siu Homo sapiens STE_MAP4K1_HUMAN STE 4e-91 310.9 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9BI8A Q92918 6 293 833.0 A1APL:60301 Type1 Inactive DFGinter 10.88 6.392 None -84.61, 129.22 -97.99, 100.09 -110.18, 33.34 298.01, 131.21 -69.67, 73.48 out-out out 13.764 Saltbr-out 14.074 HRD-in -72.89, -53.57 81.64, -15.14 out-out-out SNCooo out-out ActLoopNT-out 12.228 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -88.01, -22.61 APE9-dihe-na 97.47, -162.62 APE8-dihe-in -70.31, 141.95 APE8-rot-out 187.73 APE67-dihe-in -58.8, -30.03 -104.05, -8.58 APE12-dist-out 20.556 APE11-dist-out 20.704 APE10-dist-out 21.839 APE9-dist-out 20.928 None None None XRAY 2.25 0.203 0.271 A 311 288 0 0 0 0 [[17, 274]] 1.0 9bi8 Homo sapiens STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9BI8B Q92918 6 293 833.0 A1APL:60302 Type1 Inactive DFGinter 10.74 6.23 None -97.5, 135.14 -108.73, 95.26 -106.77, 39.31 297.68, 134.76 -83.18, 62.11 out-out out 13.997 Saltbr-out 14.039 HRD-in -72.45, -53.25 76.92, -14.23 out-out-out SNCooo out-out ActLoopNT-out 12.839 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -130.02, -27.74 APE9-dihe-na 93.81, 172.9 APE8-dihe-in -65.36, 145.02 APE8-rot-out 198.59 APE67-dihe-in -58.71, -28.43 -102.52, -7.42 APE12-dist-out 22.486 APE11-dist-out 22.102 APE10-dist-out 20.6 APE9-dist-out 22.057 None None None XRAY 2.25 0.203 0.271 B 311 288 0 0 0 0 [[17, 274]] 1.0 9bi8 Homo sapiens STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9N9XA Q92918 6 293 833.0 A1BWL:60303 Type1 Inactive DFGinter 10.661 6.351 None -84.76, 134.66 -105.03, 107.01 -114.17, 28.48 294.9, 125.35 -58.6, 75.75 out-out out 13.958 Saltbr-out 13.908 HRD-in -69.29, -54.46 84.81, -14.35 out-out-out SNCooo out-out ActLoopNT-out 12.469 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.99, -16.32 APE9-dihe-na 85.41, -173.0 APE8-dihe-in -61.5, 138.0 APE8-rot-out 189.55 APE67-dihe-in -57.89, -33.43 -97.6, -11.25 APE12-dist-out 20.846 APE11-dist-out 20.756 APE10-dist-out 21.579 APE9-dist-out 20.677 None None None XRAY 2.3 0.227 0.276 A 311 288 0 0 0 0 [[17, 274]] 1.0 9n9x Homo sapiens STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9N9XB Q92918 5 293 833.0 A1BWL:60303 Type1 Inactive DFGinter 10.659 6.162 None -80.37, 148.27 -120.58, 99.48 -108.65, 34.73 297.74, 123.66 -67.08, 76.96 out-out out 14.045 Saltbr-out 13.883 HRD-in -72.97, -55.95 86.29, -23.53 out-out-out SNCooo out-out ActLoopNT-out 13.033 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -142.31, -31.43 APE9-dihe-na 78.86, 177.37 APE8-dihe-in -56.88, 138.49 APE8-rot-out 57.19 APE67-dihe-in -66.47, -29.19 -92.99, -1.5 APE12-dist-out 21.885 APE11-dist-out 21.794 APE10-dist-out 20.426 APE9-dist-out 22.322 None None None XRAY 2.3 0.227 0.276 B 311 289 0 0 0 0 [[17, 274]] 1.0 9n9x Homo sapiens STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7M0KA Q92918 6 294 833.0 YK7:301 Type1 Inactive DFGout 14.38 9.282 BBAminus -82.3, 127.5 -108.13, 109.39 -92.58, 8.94 296.45, 85.82 -60.45, -29.18 out-out out 12.684 Saltbr-out 10.589 HRD-in -69.78, -44.39 74.68, -4.23 out-out-out SNCooo out-out ActLoopNT-out 10.041 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -64.61, -29.22 APE9-dihe-na 78.69, -174.49 APE8-dihe-in -60.92, 129.35 APE8-rot-out 191.1 APE67-dihe-in -68.64, -29.1 -96.97, -0.09 APE12-dist-out 18.536 APE11-dist-out 18.248 APE10-dist-out 18.348 APE9-dist-out 21.588 None None None XRAY 2.01 0.248 0.278 A 289 289 0 0 0 0 [[17, 274]] 1.0 7m0k Homo sapiens STE_MAP4K1_HUMAN STE 3.8e-92 314.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7M0KB Q92918 8 294 833.0 YK7:301 Type1 Inactive DFGout 14.556 9.244 BBAminus -84.24, 127.09 -106.78, 108.88 -92.96, 3.49 301.42, 86.85 -59.34, -32.37 out-out out 13.258 Saltbr-out 10.295 HRD-in -69.73, -43.43 74.85, -2.63 out-out-out SNCooo out-out ActLoopNT-out 10.733 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -68.65, -29.31 APE9-dihe-na 76.74, -172.39 APE8-dihe-in -61.0, 130.59 APE8-rot-out 51.68 APE67-dihe-in -68.9, -29.49 -91.58, -0.02 APE12-dist-out 18.527 APE11-dist-out 17.326 APE10-dist-out 17.979 APE9-dist-out 21.377 None None None XRAY 2.01 0.248 0.278 B 289 287 0 0 0 0 [[17, 274]] 1.0 7m0k Homo sapiens STE_MAP4K1_HUMAN STE 3.8e-92 314.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7M0KC Q92918 8 294 833.0 YK7:301 Type1 Inactive DFGout 14.747 9.193 BBAminus -83.02, 126.6 -104.83, 108.45 -92.61, 4.19 299.55, 86.73 -58.9, -32.52 out-out out 13.052 Saltbr-out 10.865 HRD-in -69.81, -43.58 74.75, -1.63 out-out-out SNCooo out-out ActLoopNT-out 10.739 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -68.31, -28.22 APE9-dihe-na 77.87, -176.3 APE8-dihe-in -60.14, 130.51 APE8-rot-out 51.57 APE67-dihe-in -68.87, -29.91 -92.31, -0.75 APE12-dist-out 18.58 APE11-dist-out 17.484 APE10-dist-out 17.883 APE9-dist-out 21.188 None None None XRAY 2.01 0.248 0.278 C 289 287 0 0 0 0 [[17, 274]] 1.0 7m0k Homo sapiens STE_MAP4K1_HUMAN STE 3.8e-92 314.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7M0KD Q92918 6 294 833.0 YK7:301 Type1 Inactive DFGout 14.184 9.527 BBAminus -83.63, 126.84 -106.68, 106.05 -94.4, 6.0 302.62, 86.87 -62.71, -28.5 out-out out 12.654 Saltbr-out 9.241 HRD-in -69.65, -44.42 75.51, -4.67 out-out-out SNCooo out-out ActLoopNT-out 10.084 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -64.4, -29.63 APE9-dihe-na 78.61, -174.89 APE8-dihe-in -60.94, 129.64 APE8-rot-out 191.32 APE67-dihe-in -67.7, -29.48 -96.47, 0.29 APE12-dist-out 18.251 APE11-dist-out 17.87 APE10-dist-out 17.914 APE9-dist-out 21.542 None None None XRAY 2.01 0.248 0.278 D 289 289 0 0 0 0 [[17, 274]] 1.0 7m0k Homo sapiens STE_MAP4K1_HUMAN STE 3.8e-92 314.2 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7M0LA Q92918 6 294 833.0 YK4:301 Type1 Inactive DFGout 14.902 10.045 BBAminus -71.28, 178.03 -141.2, 104.43 -97.3, 46.95 304.49, 90.24 -84.8, -71.52 out-out out 13.467 Saltbr-out 11.202 HRD-in -68.11, -44.69 74.67, -1.39 out-out-out SNCooo out-out ActLoopNT-out 9.998 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -57.77, -34.08 APE9-dihe-na 74.25, 174.22 APE8-dihe-in -46.91, 123.76 APE8-rot-out 49.48 APE67-dihe-in -66.71, -32.87 -89.18, 0.28 APE12-dist-out 18.95 APE11-dist-out 19.692 APE10-dist-out 18.759 APE9-dist-out 21.445 None None None XRAY 2.43 0.247 0.293 A 290 289 0 0 0 0 [[17, 274]] 1.0 7m0l Homo sapiens STE_MAP4K1_HUMAN STE 3.9e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7M0LB Q92918 7 291 833.0 YK4:301 Type1 Inactive DFGout 15.61 10.209 BBAminus -70.94, 176.88 -141.02, 102.53 -97.9, 45.28 304.85, 90.25 -88.09, -75.03 out-out out 13.727 Saltbr-out 11.209 HRD-in -66.64, -44.4 75.03, -0.95 out-out-out SNCooo out-out ActLoopNT-out 10.439 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -58.84, -34.7 APE9-dihe-na 74.6, 170.86 APE8-dihe-in -43.86, 123.95 APE8-rot-out 48.0 APE67-dihe-in -67.03, -32.95 -86.15, -1.97 APE12-dist-out 18.821 APE11-dist-out 19.065 APE10-dist-out 18.033 APE9-dist-out 21.124 None None None XRAY 2.43 0.247 0.293 B 290 285 0 0 0 0 [[17, 274]] 1.0 7m0l Homo sapiens STE_MAP4K1_HUMAN STE 3.9e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7M0LC Q92918 5 293 833.0 YK4:301 Type1 Inactive DFGout 15.53 10.394 BBAminus -71.65, 178.05 -140.2, 103.38 -97.38, 46.57 306.96, 90.71 -89.66, -75.36 out-out out 13.736 Saltbr-out 11.256 HRD-in -66.05, -45.63 75.21, -1.09 out-out-out SNCooo out-out ActLoopNT-out 10.542 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -56.43, -35.65 APE9-dihe-na 76.18, 166.86 APE8-dihe-in -44.06, 124.4 APE8-rot-out 47.86 APE67-dihe-in -66.88, -33.48 -86.46, -1.75 APE12-dist-out 18.956 APE11-dist-out 19.052 APE10-dist-out 17.978 APE9-dist-out 20.967 None None None XRAY 2.43 0.247 0.293 C 290 289 0 0 0 0 [[17, 274]] 1.0 7m0l Homo sapiens STE_MAP4K1_HUMAN STE 3.9e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 7M0LD Q92918 6 294 833.0 YK4:301 Type1 Inactive DFGout 15.055 10.164 BBAminus -71.92, 179.1 -140.53, 104.62 -96.34, 48.54 303.88, 89.32 -84.2, -73.4 out-out out 13.331 Saltbr-out 10.975 HRD-in -67.59, -45.21 75.46, -2.9 out-out-out SNCooo out-out ActLoopNT-out 10.088 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -59.91, -35.42 APE9-dihe-na 70.42, 178.96 APE8-dihe-in -46.62, 123.18 APE8-rot-out 48.98 APE67-dihe-in -68.16, -32.32 -90.56, -1.23 APE12-dist-out 18.879 APE11-dist-out 19.363 APE10-dist-out 18.66 APE9-dist-out 21.346 None None None XRAY 2.43 0.247 0.293 D 290 289 0 0 0 0 [[17, 274]] 1.0 7m0l Homo sapiens STE_MAP4K1_HUMAN STE 3.9e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8XN7A Q92918 6 292 833.0 A1LVT:301 Type1 Inactive DFGout 14.345 8.503 BBAminus -88.75, 151.47 -138.7, 126.73 -107.63, 21.41 291.25, 85.46 -71.58, -35.21 out-out out 12.452 Saltbr-out 9.821 HRD-in -58.31, -58.38 91.57, -25.59 out-out-out SNCooo out-out ActLoopNT-out 10.863 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -64.68, -28.8 APE9-dihe-na 70.41, -167.61 APE8-dihe-in -58.65, 130.58 APE8-rot-in 298.7 APE67-dihe-in -73.02, -31.33 -104.12, 4.31 APE12-dist-out 17.739 APE11-dist-out 17.886 APE10-dist-out 17.981 APE9-dist-out 22.532 T165E,S171E None None XRAY 2.65 0.216 0.23 A 296 287 0 0 0 0 [[17, 274]] 1.0 8xn7 Homo sapiens STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8XN7B Q92918 6 293 833.0 A1LVT:301 Type1 Inactive DFGout 14.344 8.441 BBAminus -88.25, 152.38 -137.37, 125.89 -108.54, 21.47 292.51, 85.61 -69.84, -31.75 out-out out 12.646 Saltbr-out 9.784 HRD-in -65.26, -49.86 82.38, -14.29 out-out-out SNCooo out-out ActLoopNT-out 11.266 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -70.2, -26.89 APE9-dihe-na 72.95, -172.4 APE8-dihe-in -61.15, 131.32 APE8-rot-in 303.09 APE67-dihe-in -73.29, -31.98 -103.73, 3.33 APE12-dist-out 17.784 APE11-dist-out 16.391 APE10-dist-out 16.978 APE9-dist-out 21.515 T165E,S171E None None XRAY 2.65 0.216 0.23 B 296 288 0 0 0 0 [[17, 274]] 1.0 8xn7 Homo sapiens STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 6NG0B Q92918 7 293 833.0 B49:9000 Type1 Inactive DFGout 15.022 9.027 BBAminus -132.93, 173.24 -130.35, 91.11 -75.14, -30.73 272.68, 88.14 -91.62, -130.52 out-out out 11.213 Saltbr-out 7.483 HRD-in -72.09, -46.07 68.34, -7.21 out-out-out SNCooo out-out ActLoopNT-out 6.11 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.37, 118.48 APE9-dihe-na -63.42, 177.66 APE8-dihe-in -42.4, 131.86 APE8-rot-out 56.61 APE67-dihe-in -50.2, -28.57 -93.94, -13.91 APE12-dist-out 19.976 APE11-dist-out 20.334 APE10-dist-out 21.461 APE9-dist-out 26.729 T165E,S171E None None XRAY 2.05 0.202 0.229 B 309 279 8 0 0 0 [[17, 274]] 1.0 6ng0 Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9BIKA Q92918 6 293 833.0 A1APO:60305 Type1 Inactive DFGout 11.049 6.429 BBAminus -86.09, 138.02 -107.53, 93.71 -107.56, 23.89 298.14, 124.18 -51.45, -27.27 out-out out 13.789 Saltbr-out 15.086 HRD-in -65.37, -54.34 81.94, -7.09 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -75.89, -68.71 APE9-dihe-na 67.03, -121.46 APE8-dihe-in -103.1, 131.35 APE8-rot-out 193.66 APE67-dihe-in -68.7, -24.1 -99.33, 8.23 APE12-dist-out 18.958 APE11-dist-out 18.254 APE10-dist-out 18.059 APE9-dist-out 25.386 None None None XRAY 2.25 0.199 0.244 A 311 277 11 0 0 9 [[17, 274]] 1.0 9bik Homo sapiens STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9N7RB Q92918 8 293 833.0 A1BWC:60303 Type1 Inactive DFGout 13.297 7.461 BBAminus -95.98, 130.04 -92.56, 107.91 -107.94, 11.95 278.7, 152.36 -51.43, -31.57 out-out out 14.109 Saltbr-out 11.998 HRD-in -70.53, -47.56 77.61, -10.23 out-out-out SNCooo out-out ActLoopNT-out 10.003 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -82.83, -34.63 APE9-dihe-na 119.15, 153.13 APE8-dihe-in -69.07, 159.39 APE8-rot-out 47.32 APE67-dihe-in -62.98, -31.32 -84.37, -15.77 APE12-dist-out 18.622 APE11-dist-out 18.323 APE10-dist-out 17.047 APE9-dist-out 19.026 None None None XRAY 2.13 0.181 0.227 B 311 286 0 0 0 0 [[17, 274]] 1.0 9n7r Homo sapiens STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 9N7RA Q92918 6 293 833.0 A1BWC:60311,A1BWC:60312,A1BWC:60313,A1BWC:60314 Allosteric,Allosteric,Type1,Type3 Inactive DFGout 17.032 11.8 None -129.06, 178.2 -145.13, 177.54 -61.13, -39.48 183.33, 82.96 102.23, 179.57 out-out out 13.632 Saltbr-out 11.265 HRD-in -73.28, -53.35 86.93, -14.11 out-out-out SNCooo out-out ActLoopNT-out 13.906 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -81.55, -0.66 APE9-dihe-na 85.8, 22.09 APE8-dihe-out 64.18, 169.47 APE8-rot-out 79.18 APE67-dihe-in -67.09, -36.34 -100.57, -1.37 APE12-dist-out 17.862 APE11-dist-out 17.078 APE10-dist-out 17.236 APE9-dist-out 22.488 None None None XRAY 2.13 0.181 0.227 A 311 288 0 0 0 0 [[17, 274]] 1.0 9n7r Homo sapiens STE_MAP4K1_HUMAN STE 5e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8PAUA Q92918 7 294 833.0 XOR:1001 Type1 Inactive DFGout 12.502 8.937 None -85.41, 114.68 -96.13, 139.33 -109.83, 159.8 292.92, 88.01 145.69, 999.0 out-out out 13.219 Saltbr-out 12.099 HRD-in -61.81, -50.9 82.78, -10.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -89.69, -5.15 APE9-dihe-na 127.7, 166.27 APE8-dihe-in -87.46, 130.96 APE8-rot-in 325.04 APE67-dihe-in -54.13, -40.06 -71.53, -24.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.374 None None None XRAY 2.8 0.219 0.272 A 288 276 12 0 0 12 [[17, 274]] 1.0 8pau Homo sapiens STE_MAP4K1_HUMAN STE 1.3e-92 315.7 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8PAUB Q92918 7 294 833.0 XOR:1001 Type1 Inactive DFGout 12.519 8.959 None -85.91, 115.0 -96.04, 138.99 -110.13, 158.13 294.35, 88.25 150.56, 999.0 out-out out 13.341 Saltbr-out 12.444 HRD-in -60.94, -50.68 83.07, -11.96 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -89.71, -5.01 APE9-dihe-na 125.94, 168.22 APE8-dihe-in -87.62, 131.63 APE8-rot-in 327.51 APE67-dihe-in -53.89, -40.26 -71.12, -25.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 20.51 None None None XRAY 2.8 0.219 0.272 B 288 276 12 0 0 12 [[17, 274]] 1.0 8pau Homo sapiens STE_MAP4K1_HUMAN STE 1.3e-92 315.7 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8PASA Q92918 8 295 833.0 XOH:1001 Type1 Inactive DFGout 17.194 11.34 None -102.48, 172.96 -123.06, 91.61 -76.46, -45.21 184.61, 68.06 -62.9, -137.65 out-out out 12.746 Saltbr-out 10.388 HRD-in -71.47, -49.47 84.52, -7.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 81.11 APE8-rot-out 192.88 APE67-dihe-in -41.49, -47.96 -71.33, -32.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.231 0.3 A 289 269 19 0 0 15 [[17, 274]] 1.0 8pas Homo sapiens STE_MAP4K1_HUMAN STE 1.4e-92 315.6 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8PASB Q92918 7 294 833.0 XOH:1001 Type1 Inactive DFGout 16.527 8.559 None -98.04, 164.09 -125.71, 93.21 -79.27, -45.4 197.01, 39.14 -93.06, 64.56 out-out out 13.068 Saltbr-out 11.979 HRD-in -70.58, -50.51 83.73, -9.49 out-out-out SNCooo out-out ActLoopNT-out 11.835 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 116.66 APE8-rot-out 72.4 APE67-dihe-in -39.94, -48.63 -94.09, -15.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.231 0.3 B 289 273 15 0 0 12 [[17, 274]] 1.0 8pas Homo sapiens STE_MAP4K1_HUMAN STE 1.4e-92 315.6 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8CDWA Q92918 7 294 833.0 UES:401 Type1 Inactive DFGout 12.943 10.181 None -88.94, 138.44 -85.59, 110.01 -95.36, 999.0 303.83, 5.34 999.0, 999.0 out-out out 12.997 Saltbr-out 12.142 HRD-in -68.21, -45.06 72.04, -15.38 out-out-out SNCooo out-out ActLoopNT-out 9.782 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -61.85, -37.25 APE9-dihe-na 89.35, -173.76 APE8-dihe-in -63.78, 133.43 APE8-rot-out 48.38 APE67-dihe-in -57.9, -34.4 -95.8, -2.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 21.11 None None None XRAY 1.941 0.229 0.252 A 307 285 3 0 0 3 [[17, 274]] 1.0 8cdw Homo sapiens STE_MAP4K1_HUMAN STE 4.8e-92 313.9 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8CIJA Q92918 14 294 833.0 USF:401 Type1 Inactive DFGout 11.213 7.331 None -112.58, 122.54 -96.1, 115.56 -121.01, 999.0 297.98, 106.95 999.0, 999.0 out-out out 13.535 Saltbr-out 11.8 HRD-in -61.67, -48.53 69.18, 2.25 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -87.98, 122.06 APE9-dihe-na 145.78, 142.84 APE8-dihe-in -120.8, 116.13 APE8-rot-in 320.07 APE67-dihe-in -58.16, -27.75 -31.5, -57.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.681 None None None XRAY 2.821 0.239 0.266 A 307 264 17 0 0 12 [[17, 274]] 1.0 8cij Homo sapiens STE_MAP4K1_HUMAN STE 4.8e-92 313.9 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8PARA Q92918 7 294 833.0 XON:402 Type1 Inactive DFGout 14.971 8.334 None -85.12, 139.88 -106.78, 86.97 -93.71, -153.54 212.58, 74.65 90.72, 999.0 out-out out 14.169 Saltbr-out 12.168 HRD-in -64.66, -52.5 81.78, -15.49 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 169.98 APE8-dihe-in -64.02, 158.26 APE8-rot-out 59.07 APE67-dihe-in -62.49, -27.18 -94.28, 3.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 21.369 T165E,S171E None None XRAY 2.0 0.242 0.292 A 308 268 20 0 0 16 [[17, 274]] 1.0 8par Homo sapiens STE_MAP4K1_HUMAN STE 4.8e-92 313.9 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8FKOF Q92918 57 292 833.0 No_ligand No_ligand Inactive None 6.584 999.0 None -130.11, 169.82 68.72, 80.6 -90.27, 25.22 286.89, 93.32 -62.48, -41.27 none-none none 999.0 Saltbr-none 999.0 HRD-in -79.1, -46.03 67.61, -7.09 none-out-out SNCnoo out-out ActLoopNT-out 6.119 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -65.82, -29.85 APE9-dihe-na 74.43, -162.11 APE8-dihe-in -54.25, 130.28 APE8-rot-out 204.88 APE67-dihe-in -55.84, -31.2 -100.45, -5.05 APE12-dist-out 19.323 APE11-dist-out 21.012 APE10-dist-out 21.979 APE9-dist-out 27.951 T165E,S171E None None XRAY 2.104 0.222 0.258 F 331 224 52 0 0 0 [[17, 274]] 1.0 8fko Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 6CQEA Q92918 4 293 833.0 No_ligand No_ligand Inactive None 13.3 16.89 None -78.38, 159.45 -80.15, 141.12 -104.62, -37.54 162.44, 74.03 -60.06, -40.87 out-out out 13.207 Saltbr-out 10.933 HRD-in -68.12, -50.77 83.16, -16.98 out-out-out SNCooo out-out ActLoopNT-out 11.022 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -125.75, 162.38 APE9-dihe-na -83.75, 166.4 APE8-dihe-in -86.5, 169.52 APE8-rot-out 55.14 APE67-dihe-in -56.39, -35.1 -100.47, 3.45 APE12-dist-out 21.498 APE11-dist-out 18.233 APE10-dist-out 16.536 APE9-dist-out 20.671 S171A None None XRAY 1.886 0.207 0.258 A 295 286 4 0 0 0 [[17, 274]] 1.0 6cqe Homo sapiens STE_MAP4K1_HUMAN STE 3.9e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 6CQEB Q92918 5 293 833.0 No_ligand No_ligand Inactive None 13.606 16.666 None -80.76, 157.28 -74.99, 140.01 -104.91, -33.72 170.4, 64.14 -59.17, -42.27 out-out out 13.282 Saltbr-out 11.412 HRD-in -69.42, -46.27 82.96, -17.54 out-out-out SNCooo out-out ActLoopNT-out 11.104 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -124.41, 161.02 APE9-dihe-na -76.12, 165.91 APE8-dihe-in -92.98, 166.38 APE8-rot-out 201.74 APE67-dihe-in -59.03, -29.82 -96.28, -0.42 APE12-dist-out 21.535 APE11-dist-out 18.345 APE10-dist-out 16.557 APE9-dist-out 20.617 S171A None None XRAY 1.886 0.207 0.258 B 295 286 3 0 0 0 [[17, 274]] 1.0 6cqe Homo sapiens STE_MAP4K1_HUMAN STE 3.9e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 8CDWB Q92918 9 294 833.0 UES:401 Type1 Inactive None 999.0 999.0 None -90.95, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.693 Saltbr-out 9.501 HRD-in -69.3, -45.46 74.3, -15.92 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -164.41 APE8-dihe-in -62.34, 132.44 APE8-rot-out 50.76 APE67-dihe-in -59.34, -31.48 -97.57, 1.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 22.685 None None None XRAY 1.941 0.229 0.252 B 307 265 21 0 0 9 [[17, 274]] 1.0 8cdw Homo sapiens STE_MAP4K1_HUMAN STE 4.8e-92 313.9 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
M4K1_HUMAN 6NFZA Q92918 7 292 833.0 B49:401 Type1 None DFGin 6.284 14.02 BLAminus -132.74, -179.97 58.53, 80.12 -96.32, 31.7 293.92, 71.67 -62.29, -28.15 in-none in 8.634 Saltbr-none 999.0 HRD-in -77.39, -48.16 72.34, -9.45 none-in-in SNCnii in-in ActLoopNT-in 2.838 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.28, 161.74 APE9-dihe-na 145.04, -157.57 APE8-dihe-in -127.09, 102.67 APE8-rot-in 298.6 APE67-dihe-in -54.23, -29.76 -34.34, -51.63 APE12-dist-in 8.241 APE11-dist-in 11.626 APE10-dist-in 6.178 APE9-dist-in 3.916 None TPO165,SEP171 TPO165,SEP171 XRAY 2.966 0.209 0.251 A 309 270 16 0 0 0 [[17, 274]] 1.0 6nfz Homo sapiens STE_MAP4K1_HUMAN STE 1.7e-92 315.3 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1

STE_MAP4K1 (Mitogen-activated protein kinase kinase kinase kinase 1)

Total number of chains: 0
Active chains: 0
Family: STE
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name