TYR_KIT (Mast/stem cell growth factor receptor Kit)

Total number of chains: 68
Active chains: 22
Uniprot: KIT_HUMAN
Kinase Domain Residues: 589 - 926
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 38 55.9% 6MOBA
DFGin BLAminus 26 38.2% AF-P10721-K1A
DFGout None 3 4.4% 3G0EA
None None 1 1.5% 8PQEA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P10721-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 581 - 934 0 None None Mast/stem cell growth factor receptor Kit
AF-P10721-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 581 - 934 0 None None Mast/stem cell growth factor receptor Kit
7KHJA 2.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai WEG Type1 566 - 931 0 None None Mast/stem cell growth factor receptor Kit
7KHJB 2.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai WEG Type1 571 - 930 0 None None Mast/stem cell growth factor receptor Kit
7KHKA 2.34 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai WEJ Type1 566 - 931 0 None None Mast/stem cell growth factor receptor Kit
8PQGA 2.4 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9JI Type1 566 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,T670I,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8PQGC 2.4 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9JI Type1 565 - 932 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,T670I,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8PQ9A 1.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9JI Type1 566 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8PQ9C 1.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9JI Type1 565 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8PQAA 1.65 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 98A Type1 566 - 930 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8PQAC 1.65 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 98A Type1 566 - 932 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8PQCA 1.77 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9OO Type1 566 - 932 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8PQCB 1.77 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9OO Type1 566 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8PQDA 1.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9VV Type1 566 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8PQDB 1.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9VV Type1 566 - 932 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8PQFA 1.9 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9KI Type1 566 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8PQFC 1.9 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9KI Type1 566 - 932 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8S19A 2.3 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 566 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8S19B 2.3 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 566 - 930 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8S1AA 1.85 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6T2 Type1 565 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8S1AB 1.85 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6T2 Type1 566 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
7KHKB 2.34 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai WEJ Type1.5_Back 567 - 929 0 None None Mast/stem cell growth factor receptor Kit
1PKGA 2.9 Inactive DFGin‑BLAminus in-out in-out TYR APEdihe_oiiai APEdist_aaai ADP ATPlike 567 - 927 0 PTR568,PTR570 None Mast/stem cell growth factor receptor Kit
8S13A 2.0 Inactive DFGout‑BBAminus in-none out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 554 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8S14A 1.5 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai B49 Type1 554 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8S15A 2.4 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai XIN Type1 554 - 929 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
3G0FA 2.6 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai B49 Type1 566 - 930 0 None D816H Mast/stem cell growth factor receptor Kit
3G0FB 2.6 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai B49 Type1 564 - 930 0 None D816H Mast/stem cell growth factor receptor Kit
7ZW8A 2.119 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai K3R Type1 554 - 932 0 None None Mast/stem cell growth factor receptor Kit
6KLAA 2.109 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai DJX Type1 554 - 931 0 None None Mast/stem cell growth factor receptor Kit
4HVSA 1.9 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 647 Type2 551 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,I690H,C691S,K693D,Q694T,E695S,I756S,L762N,V825D,C844S,L890S,L912D,L923D Mast/stem cell growth factor receptor Kit
7KHGA 2.15 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai P31 Type2 547 - 931 0 None None Mast/stem cell growth factor receptor Kit
8S16A 1.85 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai STI Type2 566 - 932 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8S16B 1.85 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai STI Type2 578 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8S17A 2.2 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 0LI Type2 567 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8S17B 2.2 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 0LI Type2 578 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8S18A 2.1 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai A1H4U Type2 568 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8S18B 2.1 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai A1H4U Type2 578 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
6GQJA 2.33 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai F82 Type2 567 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
6GQJB 2.33 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai F82 Type2 572 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
6GQKA 2.31 Inactive DFGout‑BBAminus in-in out-out TYR APEdihe_iiiai APEdist_aaao F88 Type2 567 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
6GQKB 2.31 Inactive DFGout‑BBAminus in-in out-out TYR APEdihe_iiiai APEdist_aaao F88 Type2 572 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
6GQLA 2.01 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai F8B Type2 568 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
6GQLB 2.01 Inactive DFGout‑BBAminus in-in out-out TYR APEdihe_iiiai APEdist_aaao F8B Type2 577 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
6GQMA 2.0 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai F8H Type2 569 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
6GQMB 2.0 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai F8H Type2 577 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
6XV9A 3.38 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai O35 Type2 566 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
6XV9B 3.38 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai O35 Type2 572 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
6XVAA 2.3 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai O2K Type2 569 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
6XVAB 2.3 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai O2K Type2 577 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
6XVBA 2.15 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai O2H Type2 569 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
6XVBB 2.15 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai O2H Type2 577 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
6HH1A 2.25 Inactive DFGout‑BBAminus in-in none-none TYR APEdihe_iiiai APEdist_aaan G4E Type2 565 - 929 0 None None Mast/stem cell growth factor receptor Kit
6MOBA 1.8 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai JWY Type2 567 - 930 0 None None Mast/stem cell growth factor receptor Kit
1T46A 1.6 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai STI Type2 565 - 933 0 None None Mast/stem cell growth factor receptor Kit
4U0IA 2.0 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 0LI Type2 565 - 933 0 None None Mast/stem cell growth factor receptor Kit
7ZY6A 3.09 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai KCI Type2 557 - 932 0 None None Mast/stem cell growth factor receptor Kit
6ITTA 2.103 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai AWO Type2 563 - 932 0 None None Mast/stem cell growth factor receptor Kit
6ITTB 2.103 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai AWO Type2 566 - 932 0 None None Mast/stem cell growth factor receptor Kit
6ITVA 1.881 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai AWO Type2 569 - 935 0 PTR570 None Mast/stem cell growth factor receptor Kit
8S1BB 2.0 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai K3R, K3R, K3R Type2, Allosteric, Allosteric 565 - 930 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
1T45A 1.9 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 547 - 935 0 None None Mast/stem cell growth factor receptor Kit
3G0EA 1.6 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai B49 Type1 544 - 931 0 None None Mast/stem cell growth factor receptor Kit
8S1BA 2.0 Inactive DFGout‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai K3R Type2 565 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8PQEA 2.0 Inactive None‑None in-in none-none TYR APEdihe_niiai APEdist_aaai 9WU Type1 566 - 930 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
1PKGB 2.9 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai ADP ATPlike 566 - 929 0 PTR568,PTR570 None Mast/stem cell growth factor receptor Kit
8PQBA 1.87 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 9XO Type1 567 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
8PQEB 2.0 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 9WU Type1 566 - 930 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit

TYR_KIT (Mast/stem cell growth factor receptor Kit)

Total number of chains: 68
Active chains: 22
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 38 55.9% 6MOBA
DFGin BLAminus 26 38.2% AF-P10721-K1A
DFGout None 3 4.4% 3G0EA
None None 1 1.5% 8PQEA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
KIT_HUMAN AF-P10721-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 581 - 934 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN AF-P10721-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 581 - 934 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 7KHJA 2.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai WEG Type1 566 - 931 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 7KHJB 2.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai WEG Type1 571 - 930 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 7KHKA 2.34 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai WEJ Type1 566 - 931 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8PQGA 2.4 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9JI Type1 566 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,T670I,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8PQGC 2.4 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9JI Type1 565 - 932 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,T670I,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8PQ9A 1.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9JI Type1 566 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8PQ9C 1.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9JI Type1 565 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8PQAA 1.65 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 98A Type1 566 - 930 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8PQAC 1.65 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 98A Type1 566 - 932 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8PQCA 1.77 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9OO Type1 566 - 932 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8PQCB 1.77 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9OO Type1 566 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8PQDA 1.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9VV Type1 566 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8PQDB 1.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9VV Type1 566 - 932 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8PQFA 1.9 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9KI Type1 566 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8PQFC 1.9 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9KI Type1 566 - 932 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8S19A 2.3 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 566 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8S19B 2.3 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 566 - 930 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8S1AA 1.85 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6T2 Type1 565 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8S1AB 1.85 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6T2 Type1 566 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 7KHKB 2.34 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai WEJ Type1.5_Back 567 - 929 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 1PKGA 2.9 Inactive DFGin‑BLAminus in-out in-out TYR APEdihe_oiiai APEdist_aaai ADP ATPlike 567 - 927 0 PTR568,PTR570 None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8S13A 2.0 Inactive DFGout‑BBAminus in-none out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 554 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8S14A 1.5 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai B49 Type1 554 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8S15A 2.4 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai XIN Type1 554 - 929 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 3G0FA 2.6 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai B49 Type1 566 - 930 0 None D816H Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 3G0FB 2.6 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai B49 Type1 564 - 930 0 None D816H Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 7ZW8A 2.119 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai K3R Type1 554 - 932 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6KLAA 2.109 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai DJX Type1 554 - 931 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 4HVSA 1.9 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 647 Type2 551 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,I690H,C691S,K693D,Q694T,E695S,I756S,L762N,V825D,C844S,L890S,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 7KHGA 2.15 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai P31 Type2 547 - 931 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8S16A 1.85 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai STI Type2 566 - 932 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8S16B 1.85 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai STI Type2 578 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8S17A 2.2 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 0LI Type2 567 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8S17B 2.2 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 0LI Type2 578 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8S18A 2.1 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai A1H4U Type2 568 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8S18B 2.1 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai A1H4U Type2 578 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6GQJA 2.33 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai F82 Type2 567 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6GQJB 2.33 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai F82 Type2 572 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6GQKA 2.31 Inactive DFGout‑BBAminus in-in out-out TYR APEdihe_iiiai APEdist_aaao F88 Type2 567 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6GQKB 2.31 Inactive DFGout‑BBAminus in-in out-out TYR APEdihe_iiiai APEdist_aaao F88 Type2 572 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6GQLA 2.01 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai F8B Type2 568 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6GQLB 2.01 Inactive DFGout‑BBAminus in-in out-out TYR APEdihe_iiiai APEdist_aaao F8B Type2 577 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6GQMA 2.0 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai F8H Type2 569 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6GQMB 2.0 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai F8H Type2 577 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6XV9A 3.38 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai O35 Type2 566 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6XV9B 3.38 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai O35 Type2 572 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6XVAA 2.3 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai O2K Type2 569 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6XVAB 2.3 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai O2K Type2 577 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6XVBA 2.15 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai O2H Type2 569 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6XVBB 2.15 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai O2H Type2 577 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6HH1A 2.25 Inactive DFGout‑BBAminus in-in none-none TYR APEdihe_iiiai APEdist_aaan G4E Type2 565 - 929 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6MOBA 1.8 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai JWY Type2 567 - 930 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 1T46A 1.6 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai STI Type2 565 - 933 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 4U0IA 2.0 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 0LI Type2 565 - 933 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 7ZY6A 3.09 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai KCI Type2 557 - 932 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6ITTA 2.103 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai AWO Type2 563 - 932 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6ITTB 2.103 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai AWO Type2 566 - 932 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 6ITVA 1.881 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai AWO Type2 569 - 935 0 PTR570 None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8S1BB 2.0 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai K3R, K3R, K3R Type2, Allosteric, Allosteric 565 - 930 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 1T45A 1.9 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 547 - 935 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 3G0EA 1.6 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai B49 Type1 544 - 931 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8S1BA 2.0 Inactive DFGout‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai K3R Type2 565 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8PQEA 2.0 Inactive None‑None in-in none-none TYR APEdihe_niiai APEdist_aaai 9WU Type1 566 - 930 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 1PKGB 2.9 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai ADP ATPlike 566 - 929 0 PTR568,PTR570 None Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8PQBA 1.87 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 9XO Type1 567 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
KIT_HUMAN 8PQEB 2.0 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 9WU Type1 566 - 930 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens

TYR_KIT (Mast/stem cell growth factor receptor Kit)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism