Protein kinases in complex with 6T2 (Crenolanib)

Total number of genes: 3
Total number of chains: 5
Spatial Dihedral Chains Representative
DFGin BLAminus 3 8S1AB
DFGin BLAplus 1 6JOIA
None None 1 6JOJA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
CAMK CAMKK2 KKCC2_HUMAN Calcium/calmodulin-dependent protein kinase kinase 2 6BQPA 1.95 Active DFGin BLAminus in-in in-in 6T2 Type1
TYR KIT KIT_HUMAN Mast/stem cell growth factor receptor Kit 8S1AA 1.85 Active DFGin BLAminus in-in in-in 6T2 Type1
TYR KIT KIT_HUMAN Mast/stem cell growth factor receptor Kit 8S1AB 1.85 Active DFGin BLAminus in-in in-in 6T2 Type1
TYR PDGFRA PGFRA_HUMAN Platelet-derived growth factor receptor alpha 6JOIA 3.1 Inactive DFGin BLAplus in-out none-in 6T2 Type1
TYR PDGFRA PGFRA_HUMAN Platelet-derived growth factor receptor alpha 6JOJA 2.6 Inactive None None in-in out-in 6T2 Type1

Protein kinases in complex with 6T2

Total number of genes: 3
Total number of chains: 5
Spatial Dihedral Chains Representative
DFGin BLAminus 3 8S1AB
DFGin BLAplus 1 6JOIA
None None 1 6JOJA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens CAMK CAMKK2 KKCC2_HUMAN Calcium/calmodulin-dependent protein kinase kinase 2 6BQPA 1.95 Active DFGin BLAminus in-in in-in 6T2 Type1
Homo sapiens TYR KIT KIT_HUMAN Mast/stem cell growth factor receptor Kit 8S1AA 1.85 Active DFGin BLAminus in-in in-in 6T2 Type1
Homo sapiens TYR KIT KIT_HUMAN Mast/stem cell growth factor receptor Kit 8S1AB 1.85 Active DFGin BLAminus in-in in-in 6T2 Type1
Homo sapiens TYR PDGFRA PGFRA_HUMAN Platelet-derived growth factor receptor alpha 6JOIA 3.1 Inactive DFGin BLAplus in-out none-in 6T2 Type1
Homo sapiens TYR PDGFRA PGFRA_HUMAN Platelet-derived growth factor receptor alpha 6JOJA 2.6 Inactive None None in-in out-in 6T2 Type1

Protein kinases in complex with 6T2

Total number of genes: 0
Total number of chains: 0
Spatial Dihedral Chains Representative
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type