TYR_KIT (Mast/stem cell growth factor receptor Kit)

Total number of chains: 68
Active chains: 22
Family: TYR
Uniprot: KIT_HUMAN
Kinase Domain Residues: 589 - 926
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 38 55.9% 6MOBA
DFGin BLAminus 26 38.2% AF-P10721-K1A
DFGout None 3 4.4% 3G0EA
None None 1 1.5% 8PQEA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P10721-K1A 581 934 976.0 No_ligand No_ligand Active DFGin 6.786 13.897 BLAminus -137.13, -177.35 65.01, 55.29 -77.83, 15.7 290.41, 84.5 -59.93, -30.98 in-in in 7.323 Saltbr-in 2.626 HRD-in -82.44, -44.53 66.57, -14.33 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.93, 86.29 APE9-dihe-in -106.7, 148.56 APE8-dihe-in -77.22, 85.6 APE8-rot-na 36.16 APE67-dihe-in -66.29, -16.54 -48.63, -37.36 APE12-dist-na 14.206 APE11-dist-na 8.149 APE10-dist-na 10.038 APE9-dist-in 6.176 None None None AF2 -1.0 1.0 1.0 A 354 354 0 0 0 0 [[589, 926]] 1.0 AF-P10721-K1 TYR_KIT_HUMAN TYR 2.7e-101 344.2 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
AF-P10721-K3A 581 934 976.0 No_ligand No_ligand Active DFGin 6.693 13.385 BLAminus -132.99, -175.92 56.33, 65.46 -74.58, 16.59 290.11, 86.3 -60.73, -30.92 in-in in 7.875 Saltbr-in 2.77 HRD-in -81.76, -44.83 66.21, -6.37 in-in-in SNCiii in-in ActLoopNT-in 2.895 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.02, 104.61 APE9-dihe-in -95.01, 154.28 APE8-dihe-in -78.39, 65.49 APE8-rot-na 36.61 APE67-dihe-in -67.79, -19.72 -50.01, -38.75 APE12-dist-na 14.481 APE11-dist-na 8.313 APE10-dist-na 11.056 APE9-dist-in 6.837 None None None AF2 -1.0 1.0 1.0 A 354 354 0 0 0 0 [[589, 926]] 1.0 AF-P10721-K3 TYR_KIT_HUMAN TYR 2.7e-101 344.2 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
7KHJA 566 931 976.0 WEG:61001 Type1 Active DFGin 6.611 13.898 BLAminus -132.69, -177.38 50.04, 76.8 -92.52, 23.6 290.02, 76.67 -56.27, -37.04 in-in in 7.663 Saltbr-in 3.294 HRD-in -79.35, -42.57 69.41, 10.19 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.7, 141.7 APE9-dihe-in -138.2, 151.32 APE8-dihe-in -79.54, 72.69 APE8-rot-na 30.14 APE67-dihe-in -69.61, -6.54 -46.54, -51.48 APE12-dist-na 999.0 APE11-dist-na 8.404 APE10-dist-na 11.082 APE9-dist-in 6.956 None None None XRAY 2.8 0.245 0.286 A 335 288 20 0 0 2 [[589, 926]] 1.0 7khj TYR_KIT_HUMAN TYR 1.1e-104 355.4 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
7KHJB 571 930 976.0 WEG:61001 Type1 Active DFGin 6.555 14.026 BLAminus -133.9, -173.37 50.96, 78.54 -96.13, 23.55 287.55, 72.9 -57.94, -35.66 in-in in 7.809 Saltbr-in 3.12 HRD-in -77.71, -37.21 66.91, 8.51 in-in-in SNCiii in-in ActLoopNT-in 3.022 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.94, 146.27 APE9-dihe-in -140.07, 155.52 APE8-dihe-in -78.0, 73.69 APE8-rot-na 31.61 APE67-dihe-in -66.82, -5.75 -44.98, -49.24 APE12-dist-na 14.146 APE11-dist-na 9.329 APE10-dist-na 11.832 APE9-dist-in 6.88 None None None XRAY 2.8 0.245 0.286 B 335 261 41 0 0 3 [[589, 926]] 1.0 7khj TYR_KIT_HUMAN TYR 1.1e-104 355.4 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
7KHKA 566 931 976.0 WEJ:61001 Type1 Active DFGin 6.622 14.272 BLAminus -140.87, -169.56 54.53, 74.43 -96.38, 20.12 284.39, 79.52 -61.52, -34.11 in-in in 7.796 Saltbr-in 2.955 HRD-in -71.94, -49.6 78.21, -7.61 in-in-in SNCiii in-in ActLoopNT-in 2.774 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.36, 145.92 APE9-dihe-in -134.49, 154.24 APE8-dihe-in -84.47, 81.8 APE8-rot-na 31.31 APE67-dihe-in -63.63, -25.49 -58.99, -41.55 APE12-dist-na 999.0 APE11-dist-na 9.105 APE10-dist-na 11.153 APE9-dist-in 7.163 None None None XRAY 2.34 0.247 0.285 A 335 291 17 0 0 2 [[589, 926]] 1.0 7khk TYR_KIT_HUMAN TYR 1.1e-104 355.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8PQGA 566 931 976.0 9JI:61001 Type1 Active DFGin 7.043 14.167 BLAminus -124.55, -174.12 54.99, 78.46 -96.45, 26.87 280.71, 70.71 -64.48, -33.68 in-in in 8.042 Saltbr-in 2.847 HRD-in -90.54, -41.04 71.94, -5.78 in-in-in SNCiii in-in ActLoopNT-in 3.025 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.66, 135.23 APE9-dihe-in -115.63, 149.54 APE8-dihe-in -83.89, 83.11 APE8-rot-na 25.85 APE67-dihe-in -70.62, -11.93 -61.47, -41.45 APE12-dist-na 999.0 APE11-dist-na 9.866 APE10-dist-na 13.032 APE9-dist-in 7.659 I563S,V569S,Y609Q,L631S,M651E,I662H,T670I,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.4 0.207 0.231 A 327 283 5 0 0 5 [[589, 926]] 1.0 8pqg TYR_KIT_HUMAN TYR 4.7e-104 353.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8PQGC 565 932 976.0 9JI:61001 Type1 Active DFGin 6.998 13.777 BLAminus -125.01, -177.18 59.69, 81.81 -99.94, 28.85 284.0, 66.15 -68.84, -20.03 in-in in 7.838 Saltbr-in 2.893 HRD-in -87.34, -47.72 75.4, 1.14 in-in-in SNCiii in-in ActLoopNT-in 2.994 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.89, 137.72 APE9-dihe-in -124.07, 148.98 APE8-dihe-in -81.48, 76.95 APE8-rot-na 33.1 APE67-dihe-in -72.2, -11.85 -56.44, -41.57 APE12-dist-na 14.367 APE11-dist-na 10.019 APE10-dist-na 12.979 APE9-dist-in 7.647 I563S,V569S,Y609Q,L631S,M651E,I662H,T670I,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.4 0.207 0.231 C 327 290 0 0 0 0 [[589, 926]] 1.0 8pqg TYR_KIT_HUMAN TYR 4.7e-104 353.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8PQ9A 566 931 976.0 9JI:61001 Type1 Active DFGin 7.252 13.815 BLAminus -126.16, 175.91 62.85, 85.59 -99.46, 22.74 287.74, 71.92 -60.52, -32.33 in-in in 8.045 Saltbr-in 2.892 HRD-in -88.42, -47.53 73.24, 0.77 in-in-in SNCiii in-in ActLoopNT-in 2.893 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.84, 137.41 APE9-dihe-in -124.52, 150.02 APE8-dihe-in -81.94, 72.53 APE8-rot-na 33.61 APE67-dihe-in -70.63, -9.48 -54.32, -43.88 APE12-dist-na 14.161 APE11-dist-na 9.659 APE10-dist-na 12.919 APE9-dist-in 7.632 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.7 0.191 0.204 A 327 288 0 0 0 0 [[589, 926]] 1.0 8pq9 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8PQ9C 565 931 976.0 9JI:61001 Type1 Active DFGin 7.253 13.629 BLAminus -125.82, 176.11 61.62, 87.15 -98.51, 24.61 286.73, 70.75 -59.71, -35.16 in-in in 7.798 Saltbr-in 2.831 HRD-in -85.3, -42.79 66.08, 3.46 in-in-in SNCiii in-in ActLoopNT-in 2.881 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.23, 137.49 APE9-dihe-in -122.07, 151.56 APE8-dihe-in -81.17, 74.2 APE8-rot-na 33.62 APE67-dihe-in -73.31, -9.55 -56.17, -42.06 APE12-dist-na 14.024 APE11-dist-na 9.741 APE10-dist-na 12.872 APE9-dist-in 7.621 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.7 0.191 0.204 C 327 289 0 0 0 0 [[589, 926]] 1.0 8pq9 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8PQAA 566 930 976.0 98A:61001 Type1 Active DFGin 7.193 13.856 BLAminus -122.96, 175.12 63.58, 85.5 -99.75, 20.34 285.92, 74.4 -56.64, -34.52 in-in in 7.944 Saltbr-in 2.729 HRD-in -94.67, -43.8 74.34, -1.0 in-in-in SNCiii in-in ActLoopNT-in 2.898 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.76, 135.8 APE9-dihe-in -118.85, 149.47 APE8-dihe-in -80.85, 69.46 APE8-rot-na 34.58 APE67-dihe-in -70.51, -9.55 -51.81, -44.71 APE12-dist-na 14.074 APE11-dist-na 9.749 APE10-dist-na 13.047 APE9-dist-in 7.64 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.65 0.189 0.214 A 327 287 0 0 0 0 [[589, 926]] 1.0 8pqa TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8PQAC 566 932 976.0 98A:61001 Type1 Active DFGin 7.365 13.871 BLAminus -128.44, 177.8 60.72, 85.37 -96.93, 21.25 285.42, 76.05 -60.3, -30.33 in-in in 7.863 Saltbr-in 2.674 HRD-in -93.28, -41.69 73.67, -0.95 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.53, 141.87 APE9-dihe-in -121.42, 146.47 APE8-dihe-in -77.65, 70.99 APE8-rot-na 35.44 APE67-dihe-in -71.59, -10.06 -56.88, -41.82 APE12-dist-na 14.203 APE11-dist-na 9.488 APE10-dist-na 13.008 APE9-dist-in 7.633 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.65 0.189 0.214 C 327 289 0 0 0 0 [[589, 926]] 1.0 8pqa TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8PQCA 566 932 976.0 9OO:61001 Type1 Active DFGin 7.32 13.728 BLAminus -124.52, 177.4 59.32, 88.07 -98.4, 24.69 287.2, 70.41 -61.62, -29.61 in-in in 7.815 Saltbr-in 2.767 HRD-in -93.83, -42.0 73.11, -0.37 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.91, 142.75 APE9-dihe-in -125.5, 151.35 APE8-dihe-in -83.13, 70.57 APE8-rot-na 37.57 APE67-dihe-in -73.25, -7.87 -53.76, -43.02 APE12-dist-na 14.042 APE11-dist-na 9.701 APE10-dist-na 13.023 APE9-dist-in 7.718 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.77 0.183 0.206 A 327 287 2 0 0 2 [[589, 926]] 1.0 8pqc TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8PQCB 566 931 976.0 9OO:61001 Type1 Active DFGin 7.283 13.835 BLAminus -128.31, 173.51 60.11, 89.0 -97.68, 23.86 286.68, 71.19 -63.1, -28.82 in-in in 7.971 Saltbr-in 2.828 HRD-in -94.17, -44.79 74.42, -0.63 in-in-in SNCiii in-in ActLoopNT-in 2.98 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.29, 141.63 APE9-dihe-in -125.35, 153.08 APE8-dihe-in -84.91, 76.41 APE8-rot-na 34.61 APE67-dihe-in -73.13, -6.88 -58.59, -41.47 APE12-dist-na 14.097 APE11-dist-na 9.739 APE10-dist-na 13.119 APE9-dist-in 7.692 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.77 0.183 0.206 B 327 287 1 0 0 1 [[589, 926]] 1.0 8pqc TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8PQDA 566 931 976.0 9VV:61001 Type1 Active DFGin 7.293 13.71 BLAminus -125.22, 174.02 64.35, 86.97 -99.96, 22.19 287.31, 74.14 -60.97, -31.0 in-in in 7.959 Saltbr-in 2.724 HRD-in -96.54, -44.33 76.17, -1.79 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.65, 142.04 APE9-dihe-in -121.46, 150.09 APE8-dihe-in -85.47, 74.64 APE8-rot-na 33.1 APE67-dihe-in -71.23, -8.89 -55.95, -43.17 APE12-dist-na 14.203 APE11-dist-na 9.884 APE10-dist-na 13.331 APE9-dist-in 7.722 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.5 0.176 0.194 A 327 288 0 0 0 0 [[589, 926]] 1.0 8pqd TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8PQDB 566 932 976.0 9VV:61001 Type1 Active DFGin 7.317 13.736 BLAminus -126.15, 174.7 62.73, 89.5 -101.98, 24.1 285.73, 74.08 -62.53, -30.1 in-in in 7.895 Saltbr-in 2.739 HRD-in -94.72, -44.07 75.73, -0.04 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.84, 140.68 APE9-dihe-in -121.78, 149.74 APE8-dihe-in -83.35, 71.92 APE8-rot-na 35.81 APE67-dihe-in -69.81, -8.26 -54.26, -45.11 APE12-dist-na 14.108 APE11-dist-na 9.808 APE10-dist-na 13.067 APE9-dist-in 7.689 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.5 0.176 0.194 B 327 289 0 0 0 0 [[589, 926]] 1.0 8pqd TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8PQFA 566 931 976.0 9KI:61001 Type1 Active DFGin 7.014 14.115 BLAminus -129.63, 178.86 58.56, 84.18 -100.12, 27.12 285.56, 70.86 -63.9, -31.9 in-in in 8.201 Saltbr-in 2.803 HRD-in -89.02, -45.2 77.26, -1.95 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.18, 135.2 APE9-dihe-in -119.42, 150.13 APE8-dihe-in -82.55, 76.11 APE8-rot-na 32.82 APE67-dihe-in -71.08, -6.74 -56.61, -43.88 APE12-dist-na 14.104 APE11-dist-na 9.535 APE10-dist-na 12.742 APE9-dist-in 7.584 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.9 0.197 0.219 A 327 285 3 0 0 2 [[589, 926]] 1.0 8pqf TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8PQFC 566 932 976.0 9KI:61001 Type1 Active DFGin 7.029 13.734 BLAminus -130.97, -177.27 58.3, 84.55 -100.6, 29.27 285.15, 69.87 -63.54, -39.98 in-in in 8.063 Saltbr-in 2.85 HRD-in -83.32, -44.04 70.24, 3.72 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.35, 134.14 APE9-dihe-in -127.54, 151.09 APE8-dihe-in -80.47, 79.59 APE8-rot-na 32.02 APE67-dihe-in -71.78, -11.06 -58.34, -43.23 APE12-dist-na 13.926 APE11-dist-na 8.992 APE10-dist-na 11.808 APE9-dist-in 7.23 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.9 0.197 0.219 C 327 287 2 0 0 2 [[589, 926]] 1.0 8pqf TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8S19A 566 931 976.0 STU:61001 Type1 Active DFGin 7.404 13.667 BLAminus -127.12, -176.58 57.62, 86.03 -104.33, 27.64 287.94, 75.89 -65.62, -32.19 in-in in 8.528 Saltbr-in 2.807 HRD-in -86.95, -44.99 76.04, 4.46 in-in-in SNCiii in-in ActLoopNT-in 2.98 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.78, 135.36 APE9-dihe-in -116.81, 146.55 APE8-dihe-in -80.8, 82.76 APE8-rot-na 31.59 APE67-dihe-in -71.09, -10.53 -60.41, -40.84 APE12-dist-na 14.65 APE11-dist-na 10.007 APE10-dist-na 13.468 APE9-dist-in 7.899 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.3 0.186 0.208 A 327 287 1 0 0 1 [[589, 926]] 1.0 8s19 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8S19B 566 930 976.0 STU:61001 Type1 Active DFGin 7.327 13.538 BLAminus -128.07, -176.35 62.24, 79.08 -101.65, 27.17 286.46, 78.41 -65.78, -31.3 in-in in 8.424 Saltbr-in 3.244 HRD-in -86.63, -46.82 74.21, 3.84 in-in-in SNCiii in-in ActLoopNT-in 2.972 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.88, 148.22 APE9-dihe-in -128.01, 146.9 APE8-dihe-in -81.2, 79.5 APE8-rot-na 31.77 APE67-dihe-in -74.43, -9.18 -60.72, -38.08 APE12-dist-na 14.121 APE11-dist-na 10.132 APE10-dist-na 13.229 APE9-dist-in 7.695 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.3 0.186 0.208 B 327 284 3 0 0 0 [[589, 926]] 1.0 8s19 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8S1AA 565 931 976.0 6T2:61001 Type1 Active DFGin 7.481 13.454 BLAminus -130.25, 174.66 66.24, 93.25 -105.72, 18.63 285.4, 75.09 -61.16, -30.32 in-in in 8.321 Saltbr-in 3.005 HRD-in -89.71, -45.27 75.21, -0.98 in-in-in SNCiii in-in ActLoopNT-in 2.851 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.31, 143.6 APE9-dihe-in -122.04, 151.68 APE8-dihe-in -82.91, 74.45 APE8-rot-na 35.68 APE67-dihe-in -72.93, -9.14 -57.9, -42.62 APE12-dist-na 13.94 APE11-dist-na 9.499 APE10-dist-na 12.956 APE9-dist-in 7.584 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.85 0.188 0.208 A 327 286 3 0 0 0 [[589, 926]] 1.0 8s1a TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8S1AB 566 931 976.0 6T2:61001 Type1 Active DFGin 7.432 13.564 BLAminus -134.77, 174.81 62.68, 90.66 -103.62, 20.87 285.06, 74.67 -61.54, -35.7 in-in in 8.31 Saltbr-in 2.716 HRD-in -95.21, -44.44 74.01, 0.64 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.03, 139.89 APE9-dihe-in -118.65, 149.04 APE8-dihe-in -82.35, 75.62 APE8-rot-na 34.69 APE67-dihe-in -73.13, -6.18 -57.98, -42.32 APE12-dist-na 14.151 APE11-dist-na 9.654 APE10-dist-na 13.127 APE9-dist-in 7.67 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.85 0.188 0.208 B 327 288 0 0 0 0 [[589, 926]] 1.0 8s1a TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
7KHKB 567 929 976.0 WEJ:61001 Type1.5_Back Active DFGin 6.498 14.235 BLAminus -142.53, -172.25 54.51, 74.71 -95.93, 18.48 280.18, 76.12 -61.98, -36.28 in-in in 7.946 Saltbr-in 2.743 HRD-in -68.07, -48.48 77.89, -8.06 in-in-in SNCiii in-in ActLoopNT-in 3.029 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.55, 143.65 APE9-dihe-in -140.59, 157.12 APE8-dihe-in -84.72, 84.57 APE8-rot-na 30.89 APE67-dihe-in -62.7, -33.9 -56.2, -38.85 APE12-dist-na 14.303 APE11-dist-na 9.162 APE10-dist-na 11.383 APE9-dist-in 7.113 None None None XRAY 2.34 0.247 0.285 B 335 266 39 0 0 2 [[589, 926]] 1.0 7khk TYR_KIT_HUMAN TYR 1.1e-104 355.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
1PKGA 567 927 976.0 ADP:1480 ATPlike Inactive DFGin 6.481 14.136 BLAminus -130.56, -161.98 47.26, 79.76 -98.59, 34.29 290.92, 88.36 -71.71, -28.0 in-out in 8.138 Saltbr-out 3.883 HRD-in -70.61, -44.29 71.47, -6.33 out-in-out SNCoio in-out ActLoopNT-in 2.981 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 81.05, 87.98 APE9-dihe-in -123.34, 167.37 APE8-dihe-in -84.87, 64.98 APE8-rot-na 27.08 APE67-dihe-in -64.22, -13.25 -46.84, -45.75 APE12-dist-na 14.817 APE11-dist-na 9.099 APE10-dist-na 11.173 APE9-dist-in 6.894 None PTR568,PTR570 PTR568,PTR570 XRAY 2.9 0.229 0.311 A 329 292 11 0 0 0 [[589, 926]] 1.0 1pkg TYR_KIT_HUMAN TYR 4.5e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8S13A 554 931 976.0 No_ligand No_ligand Inactive DFGout 15.624 11.512 BBAminus -148.4, 169.24 -129.57, 102.72 -56.93, -44.81 289.47, 76.32 66.09, -124.48 in-none in 7.441 Saltbr-none 999.0 HRD-in -79.95, -50.64 76.82, -5.45 none-out-in SNCnoi out-in ActLoopNT-out 16.346 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.22, 120.12 APE9-dihe-in -133.85, 146.63 APE8-dihe-in -82.42, 75.57 APE8-rot-na 34.6 APE67-dihe-in -69.14, -10.54 -59.81, -43.07 APE12-dist-na 17.896 APE11-dist-na 15.835 APE10-dist-na 13.419 APE9-dist-in 7.636 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.0 0.206 0.236 A 327 291 6 0 0 0 [[589, 926]] 1.0 8s13 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8S14A 554 931 976.0 B49:61001 Type1 Inactive DFGout 15.67 11.005 BBAminus -130.33, 156.75 -126.16, 102.94 -63.2, -39.5 274.42, 76.71 60.38, -127.64 in-in in 7.027 Saltbr-in 2.555 HRD-in -74.54, -47.39 71.57, -1.96 in-out-in SNCioi out-in ActLoopNT-out 16.165 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.13, 124.86 APE9-dihe-in -134.1, 147.98 APE8-dihe-in -82.5, 68.05 APE8-rot-na 34.36 APE67-dihe-in -70.91, -8.55 -58.2, -39.66 APE12-dist-na 17.889 APE11-dist-na 15.908 APE10-dist-na 13.814 APE9-dist-in 7.606 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.5 0.189 0.214 A 327 292 6 0 0 0 [[589, 926]] 1.0 8s14 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8S15A 554 929 976.0 XIN:61001 Type1 Inactive DFGout 15.636 10.752 BBAminus -151.54, 167.1 -114.68, 111.91 -64.96, -34.32 269.42, 62.99 55.55, -112.33 in-in in 7.573 Saltbr-in 2.584 HRD-in -79.41, -46.95 68.95, -3.61 in-out-in SNCioi out-in ActLoopNT-out 15.753 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.59, 118.15 APE9-dihe-in -124.52, 145.08 APE8-dihe-in -74.65, 73.9 APE8-rot-na 30.34 APE67-dihe-in -67.28, -14.41 -59.06, -44.65 APE12-dist-na 17.811 APE11-dist-na 15.115 APE10-dist-na 13.124 APE9-dist-in 7.459 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.4 0.222 0.26 A 327 295 0 0 0 0 [[589, 926]] 1.0 8s15 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
3G0FA 566 930 976.0 B49:9001 Type1 Inactive DFGout 15.932 11.024 BBAminus -133.24, 143.68 -91.38, 106.1 -85.13, 9.55 260.45, 86.5 -43.92, 131.31 in-in in 7.308 Saltbr-in 2.858 HRD-out -104.98, 124.53 -81.9, 0.65 in-out-in SNCioi out-in ActLoopNT-out 16.723 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.6, 122.46 APE9-dihe-in -125.81, 152.57 APE8-dihe-in -80.31, 82.53 APE8-rot-na 33.57 APE67-dihe-in -64.38, -18.09 -77.28, -33.89 APE12-dist-na 17.512 APE11-dist-na 13.756 APE10-dist-na 12.661 APE9-dist-in 7.497 D816H None None XRAY 2.6 0.212 0.255 A 336 291 16 0 0 0 [[589, 926]] 1.0 3g0f TYR_KIT_HUMAN TYR 9.5e-102 346.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
3G0FB 564 930 976.0 B49:9001 Type1 Inactive DFGout 16.025 10.608 BBAminus -141.97, 146.96 -100.97, 117.58 -98.35, 1.5 249.66, 85.76 -37.59, 131.92 in-in in 7.372 Saltbr-in 2.84 HRD-out -103.28, 116.42 -91.73, 18.13 in-out-in SNCioi out-in ActLoopNT-out 16.63 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.56, 113.86 APE9-dihe-in -119.17, 158.81 APE8-dihe-in -86.16, 69.24 APE8-rot-na 31.3 APE67-dihe-in -71.68, -15.15 -66.98, -25.93 APE12-dist-na 16.574 APE11-dist-na 13.473 APE10-dist-na 12.13 APE9-dist-in 7.192 D816H None None XRAY 2.6 0.212 0.255 B 336 293 16 0 0 0 [[589, 926]] 1.0 3g0f TYR_KIT_HUMAN TYR 9.5e-102 346.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
7ZW8A 554 932 976.0 K3R:1001 Type1 Inactive DFGout 16.012 10.018 BBAminus -138.08, -169.86 -159.78, 110.19 -64.11, -32.05 278.75, 82.59 52.03, -125.86 in-out in 7.721 Saltbr-out 4.364 HRD-in -61.49, -54.81 83.28, -7.92 out-out-in SNCooi out-in ActLoopNT-out 17.41 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.53, 117.94 APE9-dihe-in -118.58, 148.65 APE8-dihe-in -86.23, 67.89 APE8-rot-na 23.54 APE67-dihe-in -65.66, -17.01 -48.38, -44.77 APE12-dist-na 17.14 APE11-dist-na 12.852 APE10-dist-na 11.192 APE9-dist-in 7.887 None None None XRAY 2.119 0.212 0.25 A 327 301 14 0 0 0 [[589, 926]] 1.0 7zw8 TYR_KIT_HUMAN TYR 4.4e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6KLAA 554 931 976.0 DJX:1001 Type1 Inactive DFGout 16.031 10.495 BBAminus -144.54, -177.7 -136.39, 121.77 -66.88, -33.43 280.19, 83.19 48.43, -112.59 in-in in 7.464 Saltbr-in 3.119 HRD-in -76.38, -50.3 78.17, -9.51 in-out-in SNCioi out-in ActLoopNT-out 16.538 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.01, 114.36 APE9-dihe-in -126.31, 147.8 APE8-dihe-in -81.74, 73.59 APE8-rot-na 34.39 APE67-dihe-in -65.25, -12.32 -65.72, -36.43 APE12-dist-na 17.228 APE11-dist-na 13.724 APE10-dist-na 11.998 APE9-dist-in 7.869 None None None XRAY 2.109 0.187 0.224 A 331 309 9 0 0 0 [[589, 926]] 1.0 6kla TYR_KIT_HUMAN TYR 4.6e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
4HVSA 551 931 976.0 647:61001 Type2 Inactive DFGout 16.746 10.514 BBAminus -159.87, -170.23 -156.88, 107.58 -49.76, -38.8 288.82, 77.13 62.66, -117.3 in-in in 7.712 Saltbr-in 2.737 HRD-in -67.64, -52.36 77.34, -5.66 in-out-in SNCioi out-in ActLoopNT-out 17.051 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.37, 111.8 APE9-dihe-in -121.62, 137.52 APE8-dihe-in -74.22, 64.9 APE8-rot-na 31.15 APE67-dihe-in -65.92, -12.77 -54.47, -42.41 APE12-dist-na 16.871 APE11-dist-na 13.882 APE10-dist-na 11.234 APE9-dist-in 7.477 I563S,V569S,Y609Q,L631S,M651E,I662H,I690H,C691S,K693D,Q694T,E695S,I756S,L762N,V825D,C844S,L890S,L912D,L923D None None XRAY 1.9 0.2 0.227 A 335 323 0 0 0 0 [[589, 926]] 1.0 4hvs TYR_KIT_HUMAN TYR 5e-105 356.5 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
7KHGA 547 931 976.0 P31:61001 Type2 Inactive DFGout 16.792 10.534 BBAminus -158.09, -171.29 -155.8, 113.13 -53.22, -36.84 288.49, 77.89 59.09, -120.96 in-in in 7.674 Saltbr-in 2.792 HRD-in -71.24, -49.13 72.07, -2.92 in-out-in SNCioi out-in ActLoopNT-out 17.097 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.08, 109.74 APE9-dihe-in -119.45, 139.81 APE8-dihe-in -80.02, 70.33 APE8-rot-na 32.88 APE67-dihe-in -65.04, -11.31 -57.06, -45.0 APE12-dist-na 16.957 APE11-dist-na 13.892 APE10-dist-na 11.219 APE9-dist-in 7.602 None None None XRAY 2.15 0.184 0.203 A 335 327 0 0 0 0 [[589, 926]] 1.0 7khg TYR_KIT_HUMAN TYR 5e-105 356.5 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8S16A 566 932 976.0 STI:61001 Type2 Inactive DFGout 16.156 10.633 BBAminus -135.66, -175.47 -146.5, 109.21 -66.07, -39.1 278.01, 69.44 60.83, -124.1 in-in in 7.912 Saltbr-in 2.965 HRD-in -69.14, -53.88 78.27, -9.6 in-out-in SNCioi out-in ActLoopNT-out 16.021 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.16, 109.76 APE9-dihe-in -124.4, 150.42 APE8-dihe-in -79.68, 69.89 APE8-rot-na 33.56 APE67-dihe-in -69.51, -13.06 -61.98, -37.06 APE12-dist-na 16.436 APE11-dist-na 13.18 APE10-dist-na 11.121 APE9-dist-in 7.791 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.85 0.177 0.207 A 327 289 0 0 0 0 [[589, 926]] 1.0 8s16 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8S16B 578 931 976.0 STI:61001 Type2 Inactive DFGout 15.888 10.523 BBAminus -137.35, -173.79 -154.74, 102.74 -60.21, -39.63 280.81, 66.69 55.03, -114.07 in-in in 7.842 Saltbr-in 2.853 HRD-in -70.27, -58.28 86.53, -13.22 in-out-in SNCioi out-in ActLoopNT-out 16.122 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.71, 104.25 APE9-dihe-in -123.97, 149.57 APE8-dihe-in -79.76, 65.91 APE8-rot-na 34.81 APE67-dihe-in -69.88, -14.71 -57.96, -38.02 APE12-dist-na 17.084 APE11-dist-na 13.899 APE10-dist-na 11.436 APE9-dist-in 7.91 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.85 0.177 0.207 B 327 276 0 0 0 0 [[589, 926]] 1.0 8s16 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8S17A 567 931 976.0 0LI:61001 Type2 Inactive DFGout 15.425 9.951 BBAminus -145.25, 179.39 -143.98, 106.64 -67.34, -40.16 274.67, 96.68 58.73, -115.03 in-in in 7.749 Saltbr-in 2.696 HRD-in -73.68, -54.05 81.88, -13.47 in-out-in SNCioi out-in ActLoopNT-out 16.311 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.0, 112.95 APE9-dihe-in -124.02, 150.83 APE8-dihe-in -80.03, 74.01 APE8-rot-na 32.18 APE67-dihe-in -67.91, -14.83 -61.86, -40.28 APE12-dist-na 16.635 APE11-dist-na 13.202 APE10-dist-na 11.515 APE9-dist-in 7.701 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.2 0.203 0.228 A 327 287 0 0 0 0 [[589, 926]] 1.0 8s17 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8S17B 578 931 976.0 0LI:61001 Type2 Inactive DFGout 15.227 9.879 BBAminus -145.11, 172.96 -138.62, 103.76 -65.65, -38.27 276.93, 92.02 61.53, -118.4 in-in in 7.652 Saltbr-in 2.743 HRD-in -69.78, -55.3 82.77, -9.47 in-out-in SNCioi out-in ActLoopNT-out 16.408 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.26, 116.47 APE9-dihe-in -128.18, 149.58 APE8-dihe-in -80.46, 72.63 APE8-rot-na 32.73 APE67-dihe-in -67.64, -17.39 -58.96, -38.89 APE12-dist-na 16.505 APE11-dist-na 13.309 APE10-dist-na 11.718 APE9-dist-in 7.975 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.2 0.203 0.228 B 327 276 0 0 0 0 [[589, 926]] 1.0 8s17 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8S18A 568 931 976.0 A1H4U:61001 Type2 Inactive DFGout 14.358 9.846 BBAminus -136.5, 172.4 -143.71, 96.71 -74.26, -23.47 290.48, 134.1 43.91, -111.27 in-in in 7.768 Saltbr-in 2.833 HRD-in -78.51, -51.56 81.82, -15.01 in-out-in SNCioi out-in ActLoopNT-out 16.236 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.06, 109.89 APE9-dihe-in -125.76, 152.89 APE8-dihe-in -81.62, 69.52 APE8-rot-na 33.63 APE67-dihe-in -66.18, -17.82 -59.01, -39.86 APE12-dist-na 16.492 APE11-dist-na 13.102 APE10-dist-na 11.251 APE9-dist-in 7.774 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.1 0.194 0.218 A 327 286 0 0 0 0 [[589, 926]] 1.0 8s18 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8S18B 578 931 976.0 A1H4U:61001 Type2 Inactive DFGout 14.108 9.476 BBAminus -139.33, 158.91 -137.25, 115.01 -87.55, -17.15 295.29, 118.72 51.85, -119.38 in-in in 7.955 Saltbr-in 2.767 HRD-in -75.32, -56.82 85.0, -9.46 in-out-in SNCioi out-in ActLoopNT-out 15.856 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.84, 113.28 APE9-dihe-in -126.85, 149.08 APE8-dihe-in -82.57, 70.64 APE8-rot-na 34.25 APE67-dihe-in -68.54, -17.43 -60.68, -37.6 APE12-dist-na 16.663 APE11-dist-na 13.374 APE10-dist-na 11.56 APE9-dist-in 7.778 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.1 0.194 0.218 B 327 276 0 0 0 0 [[589, 926]] 1.0 8s18 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6GQJA 567 931 976.0 F82:1001 Type2 Inactive DFGout 15.431 9.8 BBAminus -136.14, -170.08 -155.16, 100.15 -61.78, -34.41 278.51, 89.29 45.55, -110.63 in-in in 7.709 Saltbr-in 2.785 HRD-in -67.68, -49.72 75.47, -12.89 in-out-in SNCioi out-in ActLoopNT-out 16.263 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.47, 103.38 APE9-dihe-in -113.89, 148.07 APE8-dihe-in -82.1, 66.48 APE8-rot-na 35.26 APE67-dihe-in -63.13, -15.01 -49.56, -44.22 APE12-dist-na 16.275 APE11-dist-na 13.067 APE10-dist-na 11.362 APE9-dist-in 7.977 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.33 0.183 0.217 A 327 298 6 0 0 0 [[589, 926]] 1.0 6gqj TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6GQJB 572 931 976.0 F82:1001 Type2 Inactive DFGout 15.57 9.889 BBAminus -134.09, -172.42 -152.78, 100.31 -60.59, -34.13 279.05, 88.45 48.2, -115.16 in-in in 7.673 Saltbr-in 2.774 HRD-in -74.21, -50.69 79.42, -13.47 in-out-in SNCioi out-in ActLoopNT-out 16.241 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.62, 102.98 APE9-dihe-in -113.69, 149.0 APE8-dihe-in -85.17, 67.73 APE8-rot-na 33.45 APE67-dihe-in -61.65, -16.27 -50.45, -44.13 APE12-dist-na 16.643 APE11-dist-na 13.355 APE10-dist-na 11.507 APE9-dist-in 7.985 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.33 0.183 0.217 B 327 292 7 0 0 0 [[589, 926]] 1.0 6gqj TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6GQKA 567 931 976.0 F88:61001 Type2 Inactive DFGout 16.265 10.54 BBAminus -138.36, -179.35 -150.62, 102.51 -62.45, -32.35 276.39, 87.37 49.32, -117.03 in-in in 7.663 Saltbr-in 3.188 HRD-in -73.61, -52.81 79.41, -11.37 in-out-out SNCioo out-out ActLoopNT-out 16.465 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -119.95, 100.35 APE9-dihe-in -115.33, 151.26 APE8-dihe-in -84.45, 66.8 APE8-rot-na 34.27 APE67-dihe-in -66.19, -12.65 -48.04, -43.77 APE12-dist-na 16.94 APE11-dist-na 13.676 APE10-dist-na 11.702 APE9-dist-out 8.021 I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.31 0.188 0.22 A 328 282 0 0 0 0 [[589, 926]] 1.0 6gqk TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6GQKB 572 931 976.0 F88:61001 Type2 Inactive DFGout 16.311 10.572 BBAminus -138.21, -178.47 -152.96, 103.82 -61.94, -32.56 277.07, 85.37 50.17, -117.95 in-in in 7.649 Saltbr-in 3.206 HRD-in -72.76, -53.71 79.41, -11.08 in-out-out SNCioo out-out ActLoopNT-out 16.384 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -116.06, 104.54 APE9-dihe-in -119.72, 151.19 APE8-dihe-in -85.12, 66.24 APE8-rot-na 33.44 APE67-dihe-in -66.35, -13.84 -47.54, -43.83 APE12-dist-na 17.282 APE11-dist-na 13.998 APE10-dist-na 11.892 APE9-dist-out 8.091 I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.31 0.188 0.22 B 328 277 0 0 0 0 [[589, 926]] 1.0 6gqk TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6GQLA 568 931 976.0 F8B:61001 Type2 Inactive DFGout 16.298 10.407 BBAminus -139.81, -179.58 -147.15, 104.1 -62.76, -35.23 278.0, 81.24 49.83, -115.81 in-in in 7.688 Saltbr-in 2.702 HRD-in -69.78, -53.4 80.29, -13.23 in-out-in SNCioi out-in ActLoopNT-out 16.604 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.57, 101.18 APE9-dihe-in -117.98, 151.43 APE8-dihe-in -83.84, 67.65 APE8-rot-na 33.5 APE67-dihe-in -63.86, -15.23 -50.06, -43.24 APE12-dist-na 16.889 APE11-dist-na 13.629 APE10-dist-na 11.418 APE9-dist-in 7.998 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.01 0.202 0.222 A 328 297 6 0 0 0 [[589, 926]] 1.0 6gql TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6GQLB 577 931 976.0 F8B:61001 Type2 Inactive DFGout 16.337 10.478 BBAminus -138.32, -179.86 -148.07, 104.2 -62.14, -34.67 277.43, 81.68 50.68, -116.78 in-in in 7.731 Saltbr-in 2.741 HRD-in -68.79, -54.39 79.8, -13.05 in-out-out SNCioo out-out ActLoopNT-out 16.537 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -117.3, 101.37 APE9-dihe-in -120.57, 151.18 APE8-dihe-in -84.13, 66.79 APE8-rot-na 32.76 APE67-dihe-in -64.17, -15.21 -49.48, -43.05 APE12-dist-na 17.164 APE11-dist-na 13.913 APE10-dist-na 11.519 APE9-dist-out 8.06 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.01 0.202 0.222 B 328 286 8 0 0 0 [[589, 926]] 1.0 6gql TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6GQMA 569 931 976.0 F8H:61001 Type2 Inactive DFGout 16.229 10.388 BBAminus -136.57, -179.47 -147.93, 100.03 -59.52, -34.87 275.16, 81.94 48.12, -112.93 in-in in 7.556 Saltbr-in 2.756 HRD-in -68.29, -51.8 77.27, -17.33 in-out-in SNCioi out-in ActLoopNT-out 16.474 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.29, 100.87 APE9-dihe-in -115.89, 146.45 APE8-dihe-in -80.79, 61.87 APE8-rot-na 34.09 APE67-dihe-in -66.61, -10.92 -45.17, -44.75 APE12-dist-na 16.602 APE11-dist-na 13.143 APE10-dist-na 11.005 APE9-dist-in 7.881 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.0 0.205 0.23 A 328 296 6 0 0 0 [[589, 926]] 1.0 6gqm TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6GQMB 577 931 976.0 F8H:61001 Type2 Inactive DFGout 16.208 10.398 BBAminus -135.72, -179.99 -147.49, 100.7 -59.32, -34.43 274.81, 80.92 50.64, -114.3 in-in in 7.55 Saltbr-in 2.759 HRD-in -67.84, -52.64 77.31, -15.84 in-out-in SNCioi out-in ActLoopNT-out 16.418 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.68, 94.89 APE9-dihe-in -113.11, 150.6 APE8-dihe-in -84.09, 61.58 APE8-rot-na 33.61 APE67-dihe-in -66.61, -10.94 -43.73, -45.44 APE12-dist-na 16.946 APE11-dist-na 13.535 APE10-dist-na 11.221 APE9-dist-in 7.933 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.0 0.205 0.23 B 328 288 6 0 0 0 [[589, 926]] 1.0 6gqm TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6XV9A 566 931 976.0 O35:61001 Type2 Inactive DFGout 15.543 9.748 BBAminus -131.58, -169.39 -156.72, 93.49 -62.05, -42.03 282.46, 88.43 48.41, -104.01 in-in in 7.689 Saltbr-in 2.832 HRD-in -69.28, -49.38 72.93, -5.84 in-out-in SNCioi out-in ActLoopNT-out 16.311 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.37, 97.09 APE9-dihe-in -112.0, 148.71 APE8-dihe-in -81.81, 67.27 APE8-rot-na 29.88 APE67-dihe-in -63.86, -9.66 -46.65, -44.91 APE12-dist-na 16.579 APE11-dist-na 13.135 APE10-dist-na 10.916 APE9-dist-in 7.629 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 3.38 0.197 0.247 A 328 288 0 0 0 0 [[589, 926]] 1.0 6xv9 TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6XV9B 572 931 976.0 O35:61001 Type2 Inactive DFGout 15.678 9.77 BBAminus -131.94, -171.98 -157.03, 93.9 -61.83, -41.64 282.16, 88.18 48.65, -104.6 in-in in 7.733 Saltbr-in 2.854 HRD-in -68.86, -49.09 75.5, -9.43 in-out-in SNCioi out-in ActLoopNT-out 16.206 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.51, 98.6 APE9-dihe-in -113.58, 149.31 APE8-dihe-in -82.14, 67.2 APE8-rot-na 30.55 APE67-dihe-in -64.65, -9.32 -46.19, -45.23 APE12-dist-na 16.763 APE11-dist-na 13.334 APE10-dist-na 11.149 APE9-dist-in 7.755 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 3.38 0.197 0.247 B 328 282 0 0 0 0 [[589, 926]] 1.0 6xv9 TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6XVAA 569 931 976.0 O2K:61001 Type2 Inactive DFGout 15.552 9.873 BBAminus -130.9, -166.53 -160.13, 95.6 -61.57, -39.69 279.99, 84.81 51.06, -112.95 in-in in 7.671 Saltbr-in 2.812 HRD-in -65.74, -44.71 75.29, -12.36 in-out-in SNCioi out-in ActLoopNT-out 16.456 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.89, 95.77 APE9-dihe-in -112.54, 151.67 APE8-dihe-in -83.56, 70.47 APE8-rot-na 31.96 APE67-dihe-in -64.92, -13.68 -47.25, -45.59 APE12-dist-na 16.25 APE11-dist-na 13.101 APE10-dist-na 11.187 APE9-dist-in 7.904 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.3 0.198 0.245 A 328 285 0 0 0 0 [[589, 926]] 1.0 6xva TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6XVAB 577 931 976.0 O2K:61001 Type2 Inactive DFGout 15.832 9.946 BBAminus -129.58, -168.14 -159.52, 95.6 -60.13, -40.05 280.9, 81.98 51.8, -114.7 in-in in 7.838 Saltbr-in 2.873 HRD-in -67.63, -49.04 76.72, -12.76 in-out-in SNCioi out-in ActLoopNT-out 16.3 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.1, 96.88 APE9-dihe-in -113.3, 152.94 APE8-dihe-in -84.37, 70.57 APE8-rot-na 30.8 APE67-dihe-in -65.41, -13.28 -47.31, -45.65 APE12-dist-na 16.527 APE11-dist-na 13.148 APE10-dist-na 11.354 APE9-dist-in 7.935 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.3 0.198 0.245 B 328 277 0 0 0 0 [[589, 926]] 1.0 6xva TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6XVBA 569 931 976.0 O2H:61001 Type2 Inactive DFGout 15.696 10.02 BBAminus -139.93, -171.17 -149.97, 98.79 -62.06, -36.15 280.7, 79.89 52.82, -116.74 in-in in 7.626 Saltbr-in 2.776 HRD-in -70.55, -51.81 77.37, -9.25 in-out-in SNCioi out-in ActLoopNT-out 16.539 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.91, 97.58 APE9-dihe-in -112.95, 149.34 APE8-dihe-in -83.11, 69.81 APE8-rot-na 31.26 APE67-dihe-in -62.03, -20.02 -53.33, -41.4 APE12-dist-na 16.854 APE11-dist-na 13.597 APE10-dist-na 11.232 APE9-dist-in 7.817 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.15 0.194 0.223 A 328 285 0 0 0 0 [[589, 926]] 1.0 6xvb TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6XVBB 577 931 976.0 O2H:61001 Type2 Inactive DFGout 15.815 10.031 BBAminus -139.72, -172.06 -151.07, 100.84 -60.77, -37.85 279.63, 78.82 52.08, -117.31 in-in in 7.634 Saltbr-in 2.778 HRD-in -66.84, -49.22 76.63, -10.21 in-out-in SNCioi out-in ActLoopNT-out 16.489 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.62, 98.9 APE9-dihe-in -115.12, 149.29 APE8-dihe-in -83.95, 69.91 APE8-rot-na 30.96 APE67-dihe-in -63.32, -19.92 -52.16, -41.56 APE12-dist-na 16.981 APE11-dist-na 13.768 APE10-dist-na 11.259 APE9-dist-in 7.864 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.15 0.194 0.223 B 328 277 0 0 0 0 [[589, 926]] 1.0 6xvb TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6HH1A 565 929 976.0 G4E:61002 Type2 Inactive DFGout 14.661 10.012 BBAminus -138.92, -176.56 -149.27, 99.83 -51.66, -24.64 274.87, 97.82 33.16, -115.44 in-in in 7.308 Saltbr-in 2.465 HRD-none 999.0, 999.0 999.0, 999.0 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_iiiai APEdist_aaan APE10-dihe-in -111.15, 108.76 APE9-dihe-in -124.6, 151.33 APE8-dihe-in -84.01, 72.22 APE8-rot-na 35.73 APE67-dihe-in -67.14, -12.3 -57.73, -41.96 APE12-dist-na 17.197 APE11-dist-na 14.167 APE10-dist-na 11.999 APE9-dist-none 999.0 None None None XRAY 2.25 0.208 0.273 A 303 266 0 0 0 0 [[589, 926]] 1.0 6hh1 TYR_KIT_HUMAN TYR 3.1e-102 347.3 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6MOBA 567 930 976.0 JWY:61015 Type2 Inactive DFGout 15.878 11.579 BBAminus -127.84, 149.97 -94.24, 110.85 -86.58, 15.01 261.63, 78.66 -55.34, 145.08 in-in in 6.702 Saltbr-in 2.873 HRD-in -79.72, -39.78 69.39, 0.84 in-out-in SNCioi out-in ActLoopNT-out 17.191 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.68, 117.19 APE9-dihe-in -127.37, 145.81 APE8-dihe-in -81.12, 64.9 APE8-rot-na 36.53 APE67-dihe-in -63.81, -14.22 -53.22, -40.55 APE12-dist-na 19.237 APE11-dist-na 15.935 APE10-dist-na 13.719 APE9-dist-in 7.891 None None None XRAY 1.8 0.183 0.21 A 312 304 0 0 0 0 [[589, 926]] 1.0 6mob TYR_KIT_HUMAN TYR 3.7e-102 347.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
1T46A 565 933 976.0 STI:3 Type2 Inactive DFGout 15.698 10.154 BBAminus -131.86, -173.06 -155.36, 102.8 -61.56, -32.02 275.6, 68.14 52.41, -121.03 in-in in 7.777 Saltbr-in 2.635 HRD-in -73.88, -54.0 82.13, -17.12 in-out-in SNCioi out-in ActLoopNT-out 15.995 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.78, 112.21 APE9-dihe-in -122.06, 148.23 APE8-dihe-in -76.99, 63.4 APE8-rot-na 27.97 APE67-dihe-in -65.29, -14.58 -53.78, -42.45 APE12-dist-na 17.358 APE11-dist-na 13.86 APE10-dist-na 12.062 APE9-dist-in 7.881 None None None XRAY 1.6 0.19 0.213 A 313 297 14 0 0 0 [[589, 926]] 1.0 1t46 TYR_KIT_HUMAN TYR 3.7e-102 347.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
4U0IA 565 933 976.0 0LI:1001 Type2 Inactive DFGout 15.152 9.758 BBAminus -145.62, -174.19 -155.03, 115.98 -76.91, -26.31 285.47, 90.73 51.17, -116.44 in-in in 7.686 Saltbr-in 2.619 HRD-in -74.87, -53.81 79.28, -20.01 in-out-in SNCioi out-in ActLoopNT-out 16.446 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.86, 120.83 APE9-dihe-in -126.16, 149.12 APE8-dihe-in -78.54, 70.26 APE8-rot-na 32.2 APE67-dihe-in -61.59, -16.21 -59.65, -43.09 APE12-dist-na 17.193 APE11-dist-na 14.015 APE10-dist-na 12.164 APE9-dist-in 7.681 None None None XRAY 2.0 0.204 0.239 A 315 297 12 0 0 0 [[589, 926]] 1.0 4u0i TYR_KIT_HUMAN TYR 3.8e-102 347.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
7ZY6A 557 932 976.0 KCI:1001 Type2 Inactive DFGout 16.172 10.316 BBAminus -136.78, -169.12 -153.88, 112.67 -67.2, -49.87 280.18, 88.12 64.42, -125.84 in-out in 7.505 Saltbr-out 3.808 HRD-in -58.49, -51.37 72.91, -7.18 out-out-in SNCooi out-in ActLoopNT-out 16.646 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.67, 123.05 APE9-dihe-in -122.6, 151.66 APE8-dihe-in -82.55, 76.06 APE8-rot-na 28.18 APE67-dihe-in -56.34, -24.16 -50.87, -51.7 APE12-dist-na 16.893 APE11-dist-na 12.279 APE10-dist-na 11.342 APE9-dist-in 7.708 None None None XRAY 3.09 0.226 0.298 A 327 293 15 0 0 0 [[589, 926]] 1.0 7zy6 TYR_KIT_HUMAN TYR 4.4e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6ITTA 563 932 976.0 AWO:1001 Type2 Inactive DFGout 15.484 9.996 BBAminus -135.32, -179.43 -142.96, 106.16 -65.75, -31.61 273.13, 95.47 52.92, -118.06 in-in in 7.514 Saltbr-in 2.417 HRD-in -74.63, -52.97 82.44, -12.98 in-out-in SNCioi out-in ActLoopNT-out 16.302 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.45, 111.43 APE9-dihe-in -126.25, 147.19 APE8-dihe-in -79.48, 66.78 APE8-rot-na 33.6 APE67-dihe-in -70.79, -15.46 -52.73, -40.71 APE12-dist-na 16.642 APE11-dist-na 13.251 APE10-dist-na 11.298 APE9-dist-in 7.826 None None None XRAY 2.103 0.188 0.235 A 331 301 9 0 0 0 [[589, 926]] 1.0 6itt TYR_KIT_HUMAN TYR 4.6e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6ITTB 566 932 976.0 AWO:1001 Type2 Inactive DFGout 15.854 9.954 BBAminus -133.07, -166.83 -157.39, 107.5 -64.33, -24.78 281.52, 85.55 48.34, -114.87 in-in in 7.396 Saltbr-in 2.812 HRD-in -77.26, -52.35 84.78, -20.38 in-out-in SNCioi out-in ActLoopNT-out 16.43 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.43, 115.97 APE9-dihe-in -124.11, 147.19 APE8-dihe-in -79.93, 68.79 APE8-rot-na 32.78 APE67-dihe-in -67.26, -20.31 -62.0, -32.62 APE12-dist-na 16.358 APE11-dist-na 12.759 APE10-dist-na 11.539 APE9-dist-in 7.721 None None None XRAY 2.103 0.188 0.235 B 331 297 10 0 0 0 [[589, 926]] 1.0 6itt TYR_KIT_HUMAN TYR 4.6e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
6ITVA 569 935 976.0 AWO:1001 Type2 Inactive DFGout 15.681 9.968 BBAminus -133.58, -176.04 -147.68, 101.18 -63.17, -35.25 275.27, 92.64 59.41, -120.81 in-in in 7.242 Saltbr-in 2.692 HRD-in -77.36, -52.7 81.42, -8.84 in-out-in SNCioi out-in ActLoopNT-out 16.359 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.69, 111.08 APE9-dihe-in -117.38, 154.04 APE8-dihe-in -83.08, 69.5 APE8-rot-na 33.4 APE67-dihe-in -64.37, -14.12 -61.67, -38.34 APE12-dist-na 16.4 APE11-dist-na 12.492 APE10-dist-na 11.609 APE9-dist-in 7.771 None PTR570 PTR570 XRAY 1.881 0.183 0.231 A 331 298 9 0 0 0 [[589, 926]] 1.0 6itv TYR_KIT_HUMAN TYR 4.6e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8S1BB 565 930 976.0 K3R:61001,K3R:61002,K3R:61003 Type2,Allosteric,Allosteric Inactive DFGout 16.169 10.058 BBAminus -146.83, -168.87 -158.96, 107.65 -65.61, -37.38 279.44, 81.29 53.58, -115.98 in-out in 7.801 Saltbr-out 4.493 HRD-in -74.79, -50.48 79.07, -8.17 out-out-in SNCooi out-in ActLoopNT-out 16.848 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.82, 139.49 APE9-dihe-in -122.28, 148.41 APE8-dihe-in -81.66, 77.14 APE8-rot-na 32.23 APE67-dihe-in -70.9, -9.09 -57.75, -42.87 APE12-dist-na 999.0 APE11-dist-na 12.33 APE10-dist-na 11.01 APE9-dist-in 7.722 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.0 0.204 0.231 B 327 275 13 0 0 13 [[589, 926]] 1.0 8s1b TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
1T45A 547 935 976.0 No_ligand No_ligand Inactive DFGout 15.995 8.618 None -149.03, -178.26 -114.33, 114.95 -104.67, 13.77 216.67, 60.33 -60.17, -31.26 in-in in 7.335 Saltbr-in 2.644 HRD-in -82.54, -46.77 73.44, -10.98 in-out-in SNCioi out-in ActLoopNT-out 17.676 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.95, 120.89 APE9-dihe-in -128.42, 148.93 APE8-dihe-in -80.27, 68.64 APE8-rot-na 34.24 APE67-dihe-in -66.94, -15.67 -58.16, -36.35 APE12-dist-na 19.181 APE11-dist-na 14.984 APE10-dist-na 13.176 APE9-dist-in 7.698 None None None XRAY 1.9 0.194 0.222 A 331 331 0 0 0 0 [[589, 926]] 1.0 1t45 TYR_KIT_HUMAN TYR 4.6e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
3G0EA 544 931 976.0 B49:69000 Type1 Inactive DFGout 17.746 11.185 None -121.33, 151.46 -96.26, 99.11 -97.45, -2.26 201.86, 86.92 -50.22, -44.62 in-in in 7.975 Saltbr-in 2.741 HRD-in -84.75, -49.91 86.53, -14.09 in-out-in SNCioi out-in ActLoopNT-out 17.007 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.72, 116.38 APE9-dihe-in -130.06, 149.91 APE8-dihe-in -78.23, 61.24 APE8-rot-na 30.2 APE67-dihe-in -67.26, -15.34 -60.23, -32.65 APE12-dist-na 20.171 APE11-dist-na 16.418 APE10-dist-na 14.346 APE9-dist-in 7.896 None None None XRAY 1.6 0.201 0.212 A 336 330 0 0 0 0 [[589, 926]] 1.0 3g0e TYR_KIT_HUMAN TYR 4.8e-102 347.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8S1BA 565 931 976.0 K3R:61001 Type2 Inactive DFGout 16.161 9.934 None -141.28, -177.54 -152.15, 111.48 -76.48, 999.0 278.29, 104.57 999.0, 999.0 in-in in 8.01 Saltbr-in 2.953 HRD-in -83.54, -49.08 76.6, -0.94 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.56, 134.6 APE9-dihe-in -124.31, 149.97 APE8-dihe-in -81.72, 80.43 APE8-rot-na 31.68 APE67-dihe-in -72.23, -10.16 -60.27, -44.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.579 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.0 0.204 0.231 A 327 269 20 0 0 17 [[589, 926]] 1.0 8s1b TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8PQEA 566 930 976.0 9WU:61002 Type1 Inactive None 999.0 999.0 None -123.65, 163.55 59.33, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.376 Saltbr-in 2.852 HRD-in -77.67, -50.66 77.73, -6.13 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -38.37 APE9-dihe-in -124.18, 149.41 APE8-dihe-in -83.4, 76.76 APE8-rot-na 31.5 APE67-dihe-in -70.67, -10.1 -55.54, -43.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.661 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.0 0.216 0.256 A 327 267 20 0 0 19 [[589, 926]] 1.0 8pqe TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
1PKGB 566 929 976.0 ADP:1486 ATPlike None DFGin 6.537 13.819 BLAminus -133.94, -165.75 57.9, 93.59 -119.64, 36.22 290.23, 87.19 -80.39, -20.36 in-in in 6.934 Saltbr-in 2.915 HRD-in -72.14, -51.55 69.69, 17.19 in-in-none SNCiin in-none ActLoopNT-in 2.888 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 110.55 APE9-dihe-in -141.29, 162.93 APE8-dihe-in -80.26, 78.25 APE8-rot-na 29.66 APE67-dihe-in -62.74, -24.13 -40.98, -43.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.765 APE9-dist-in 6.494 None PTR568,PTR570 PTR568,PTR570 XRAY 2.9 0.229 0.311 B 329 279 27 0 0 13 [[589, 926]] 1.0 1pkg TYR_KIT_HUMAN TYR 4.5e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8PQBA 567 931 976.0 9XO:61001 Type1 None DFGin 7.065 13.907 BLAminus -125.03, 178.92 57.85, 86.74 -99.85, 27.47 283.64, 67.72 -68.32, -23.51 in-in in 7.946 Saltbr-in 2.834 HRD-in -88.64, -44.33 73.75, -0.94 in-in-none SNCiin in-none ActLoopNT-in 2.88 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -36.37 APE9-dihe-in -123.05, 142.81 APE8-dihe-in -78.63, 73.9 APE8-rot-na 33.79 APE67-dihe-in -70.48, -9.16 -54.85, -42.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.094 APE9-dist-in 7.446 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.87 0.2 0.234 A 327 270 17 0 0 11 [[589, 926]] 1.0 8pqb TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
8PQEB 566 930 976.0 9WU:61001 Type1 None DFGin 7.234 14.115 BLAminus -126.18, 173.65 61.69, 86.72 -98.88, 21.32 288.15, 71.07 -45.22, -42.17 in-in in 8.62 Saltbr-in 3.312 HRD-in -77.31, -50.57 76.99, -5.36 in-in-none SNCiin in-none ActLoopNT-in 2.779 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 124.75 APE9-dihe-in -123.1, 151.69 APE8-dihe-in -82.48, 77.97 APE8-rot-na 31.45 APE67-dihe-in -69.72, -10.62 -57.01, -43.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.159 APE9-dist-in 7.513 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.0 0.216 0.256 B 327 274 13 0 0 13 [[589, 926]] 1.0 8pqe TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit

TYR_KIT (Mast/stem cell growth factor receptor Kit)

Total number of chains: 68
Active chains: 22
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 38 55.9% 6MOBA
DFGin BLAminus 26 38.2% AF-P10721-K1A
DFGout None 3 4.4% 3G0EA
None None 1 1.5% 8PQEA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
KIT_HUMAN AF-P10721-K1A P10721 581 934 976.0 No_ligand No_ligand Active DFGin 6.786 13.897 BLAminus -137.13, -177.35 65.01, 55.29 -77.83, 15.7 290.41, 84.5 -59.93, -30.98 in-in in 7.323 Saltbr-in 2.626 HRD-in -82.44, -44.53 66.57, -14.33 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.93, 86.29 APE9-dihe-in -106.7, 148.56 APE8-dihe-in -77.22, 85.6 APE8-rot-na 36.16 APE67-dihe-in -66.29, -16.54 -48.63, -37.36 APE12-dist-na 14.206 APE11-dist-na 8.149 APE10-dist-na 10.038 APE9-dist-in 6.176 None None None AF2 -1.0 1.0 1.0 A 354 354 0 0 0 0 [[589, 926]] 1.0 AF-P10721-K1 Homo sapiens TYR_KIT_HUMAN TYR 2.7e-101 344.2 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN AF-P10721-K3A P10721 581 934 976.0 No_ligand No_ligand Active DFGin 6.693 13.385 BLAminus -132.99, -175.92 56.33, 65.46 -74.58, 16.59 290.11, 86.3 -60.73, -30.92 in-in in 7.875 Saltbr-in 2.77 HRD-in -81.76, -44.83 66.21, -6.37 in-in-in SNCiii in-in ActLoopNT-in 2.895 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.02, 104.61 APE9-dihe-in -95.01, 154.28 APE8-dihe-in -78.39, 65.49 APE8-rot-na 36.61 APE67-dihe-in -67.79, -19.72 -50.01, -38.75 APE12-dist-na 14.481 APE11-dist-na 8.313 APE10-dist-na 11.056 APE9-dist-in 6.837 None None None AF2 -1.0 1.0 1.0 A 354 354 0 0 0 0 [[589, 926]] 1.0 AF-P10721-K3 Homo sapiens TYR_KIT_HUMAN TYR 2.7e-101 344.2 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 7KHJA P10721 566 931 976.0 WEG:61001 Type1 Active DFGin 6.611 13.898 BLAminus -132.69, -177.38 50.04, 76.8 -92.52, 23.6 290.02, 76.67 -56.27, -37.04 in-in in 7.663 Saltbr-in 3.294 HRD-in -79.35, -42.57 69.41, 10.19 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.7, 141.7 APE9-dihe-in -138.2, 151.32 APE8-dihe-in -79.54, 72.69 APE8-rot-na 30.14 APE67-dihe-in -69.61, -6.54 -46.54, -51.48 APE12-dist-na 999.0 APE11-dist-na 8.404 APE10-dist-na 11.082 APE9-dist-in 6.956 None None None XRAY 2.8 0.245 0.286 A 335 288 20 0 0 2 [[589, 926]] 1.0 7khj Homo sapiens TYR_KIT_HUMAN TYR 1.1e-104 355.4 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 7KHJB P10721 571 930 976.0 WEG:61001 Type1 Active DFGin 6.555 14.026 BLAminus -133.9, -173.37 50.96, 78.54 -96.13, 23.55 287.55, 72.9 -57.94, -35.66 in-in in 7.809 Saltbr-in 3.12 HRD-in -77.71, -37.21 66.91, 8.51 in-in-in SNCiii in-in ActLoopNT-in 3.022 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.94, 146.27 APE9-dihe-in -140.07, 155.52 APE8-dihe-in -78.0, 73.69 APE8-rot-na 31.61 APE67-dihe-in -66.82, -5.75 -44.98, -49.24 APE12-dist-na 14.146 APE11-dist-na 9.329 APE10-dist-na 11.832 APE9-dist-in 6.88 None None None XRAY 2.8 0.245 0.286 B 335 261 41 0 0 3 [[589, 926]] 1.0 7khj Homo sapiens TYR_KIT_HUMAN TYR 1.1e-104 355.4 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 7KHKA P10721 566 931 976.0 WEJ:61001 Type1 Active DFGin 6.622 14.272 BLAminus -140.87, -169.56 54.53, 74.43 -96.38, 20.12 284.39, 79.52 -61.52, -34.11 in-in in 7.796 Saltbr-in 2.955 HRD-in -71.94, -49.6 78.21, -7.61 in-in-in SNCiii in-in ActLoopNT-in 2.774 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.36, 145.92 APE9-dihe-in -134.49, 154.24 APE8-dihe-in -84.47, 81.8 APE8-rot-na 31.31 APE67-dihe-in -63.63, -25.49 -58.99, -41.55 APE12-dist-na 999.0 APE11-dist-na 9.105 APE10-dist-na 11.153 APE9-dist-in 7.163 None None None XRAY 2.34 0.247 0.285 A 335 291 17 0 0 2 [[589, 926]] 1.0 7khk Homo sapiens TYR_KIT_HUMAN TYR 1.1e-104 355.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8PQGA P10721 566 931 976.0 9JI:61001 Type1 Active DFGin 7.043 14.167 BLAminus -124.55, -174.12 54.99, 78.46 -96.45, 26.87 280.71, 70.71 -64.48, -33.68 in-in in 8.042 Saltbr-in 2.847 HRD-in -90.54, -41.04 71.94, -5.78 in-in-in SNCiii in-in ActLoopNT-in 3.025 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.66, 135.23 APE9-dihe-in -115.63, 149.54 APE8-dihe-in -83.89, 83.11 APE8-rot-na 25.85 APE67-dihe-in -70.62, -11.93 -61.47, -41.45 APE12-dist-na 999.0 APE11-dist-na 9.866 APE10-dist-na 13.032 APE9-dist-in 7.659 I563S,V569S,Y609Q,L631S,M651E,I662H,T670I,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.4 0.207 0.231 A 327 283 5 0 0 5 [[589, 926]] 1.0 8pqg Homo sapiens TYR_KIT_HUMAN TYR 4.7e-104 353.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8PQGC P10721 565 932 976.0 9JI:61001 Type1 Active DFGin 6.998 13.777 BLAminus -125.01, -177.18 59.69, 81.81 -99.94, 28.85 284.0, 66.15 -68.84, -20.03 in-in in 7.838 Saltbr-in 2.893 HRD-in -87.34, -47.72 75.4, 1.14 in-in-in SNCiii in-in ActLoopNT-in 2.994 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.89, 137.72 APE9-dihe-in -124.07, 148.98 APE8-dihe-in -81.48, 76.95 APE8-rot-na 33.1 APE67-dihe-in -72.2, -11.85 -56.44, -41.57 APE12-dist-na 14.367 APE11-dist-na 10.019 APE10-dist-na 12.979 APE9-dist-in 7.647 I563S,V569S,Y609Q,L631S,M651E,I662H,T670I,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.4 0.207 0.231 C 327 290 0 0 0 0 [[589, 926]] 1.0 8pqg Homo sapiens TYR_KIT_HUMAN TYR 4.7e-104 353.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8PQ9A P10721 566 931 976.0 9JI:61001 Type1 Active DFGin 7.252 13.815 BLAminus -126.16, 175.91 62.85, 85.59 -99.46, 22.74 287.74, 71.92 -60.52, -32.33 in-in in 8.045 Saltbr-in 2.892 HRD-in -88.42, -47.53 73.24, 0.77 in-in-in SNCiii in-in ActLoopNT-in 2.893 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.84, 137.41 APE9-dihe-in -124.52, 150.02 APE8-dihe-in -81.94, 72.53 APE8-rot-na 33.61 APE67-dihe-in -70.63, -9.48 -54.32, -43.88 APE12-dist-na 14.161 APE11-dist-na 9.659 APE10-dist-na 12.919 APE9-dist-in 7.632 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.7 0.191 0.204 A 327 288 0 0 0 0 [[589, 926]] 1.0 8pq9 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8PQ9C P10721 565 931 976.0 9JI:61001 Type1 Active DFGin 7.253 13.629 BLAminus -125.82, 176.11 61.62, 87.15 -98.51, 24.61 286.73, 70.75 -59.71, -35.16 in-in in 7.798 Saltbr-in 2.831 HRD-in -85.3, -42.79 66.08, 3.46 in-in-in SNCiii in-in ActLoopNT-in 2.881 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.23, 137.49 APE9-dihe-in -122.07, 151.56 APE8-dihe-in -81.17, 74.2 APE8-rot-na 33.62 APE67-dihe-in -73.31, -9.55 -56.17, -42.06 APE12-dist-na 14.024 APE11-dist-na 9.741 APE10-dist-na 12.872 APE9-dist-in 7.621 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.7 0.191 0.204 C 327 289 0 0 0 0 [[589, 926]] 1.0 8pq9 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8PQAA P10721 566 930 976.0 98A:61001 Type1 Active DFGin 7.193 13.856 BLAminus -122.96, 175.12 63.58, 85.5 -99.75, 20.34 285.92, 74.4 -56.64, -34.52 in-in in 7.944 Saltbr-in 2.729 HRD-in -94.67, -43.8 74.34, -1.0 in-in-in SNCiii in-in ActLoopNT-in 2.898 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.76, 135.8 APE9-dihe-in -118.85, 149.47 APE8-dihe-in -80.85, 69.46 APE8-rot-na 34.58 APE67-dihe-in -70.51, -9.55 -51.81, -44.71 APE12-dist-na 14.074 APE11-dist-na 9.749 APE10-dist-na 13.047 APE9-dist-in 7.64 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.65 0.189 0.214 A 327 287 0 0 0 0 [[589, 926]] 1.0 8pqa Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8PQAC P10721 566 932 976.0 98A:61001 Type1 Active DFGin 7.365 13.871 BLAminus -128.44, 177.8 60.72, 85.37 -96.93, 21.25 285.42, 76.05 -60.3, -30.33 in-in in 7.863 Saltbr-in 2.674 HRD-in -93.28, -41.69 73.67, -0.95 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.53, 141.87 APE9-dihe-in -121.42, 146.47 APE8-dihe-in -77.65, 70.99 APE8-rot-na 35.44 APE67-dihe-in -71.59, -10.06 -56.88, -41.82 APE12-dist-na 14.203 APE11-dist-na 9.488 APE10-dist-na 13.008 APE9-dist-in 7.633 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.65 0.189 0.214 C 327 289 0 0 0 0 [[589, 926]] 1.0 8pqa Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8PQCA P10721 566 932 976.0 9OO:61001 Type1 Active DFGin 7.32 13.728 BLAminus -124.52, 177.4 59.32, 88.07 -98.4, 24.69 287.2, 70.41 -61.62, -29.61 in-in in 7.815 Saltbr-in 2.767 HRD-in -93.83, -42.0 73.11, -0.37 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.91, 142.75 APE9-dihe-in -125.5, 151.35 APE8-dihe-in -83.13, 70.57 APE8-rot-na 37.57 APE67-dihe-in -73.25, -7.87 -53.76, -43.02 APE12-dist-na 14.042 APE11-dist-na 9.701 APE10-dist-na 13.023 APE9-dist-in 7.718 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.77 0.183 0.206 A 327 287 2 0 0 2 [[589, 926]] 1.0 8pqc Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8PQCB P10721 566 931 976.0 9OO:61001 Type1 Active DFGin 7.283 13.835 BLAminus -128.31, 173.51 60.11, 89.0 -97.68, 23.86 286.68, 71.19 -63.1, -28.82 in-in in 7.971 Saltbr-in 2.828 HRD-in -94.17, -44.79 74.42, -0.63 in-in-in SNCiii in-in ActLoopNT-in 2.98 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.29, 141.63 APE9-dihe-in -125.35, 153.08 APE8-dihe-in -84.91, 76.41 APE8-rot-na 34.61 APE67-dihe-in -73.13, -6.88 -58.59, -41.47 APE12-dist-na 14.097 APE11-dist-na 9.739 APE10-dist-na 13.119 APE9-dist-in 7.692 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.77 0.183 0.206 B 327 287 1 0 0 1 [[589, 926]] 1.0 8pqc Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8PQDA P10721 566 931 976.0 9VV:61001 Type1 Active DFGin 7.293 13.71 BLAminus -125.22, 174.02 64.35, 86.97 -99.96, 22.19 287.31, 74.14 -60.97, -31.0 in-in in 7.959 Saltbr-in 2.724 HRD-in -96.54, -44.33 76.17, -1.79 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.65, 142.04 APE9-dihe-in -121.46, 150.09 APE8-dihe-in -85.47, 74.64 APE8-rot-na 33.1 APE67-dihe-in -71.23, -8.89 -55.95, -43.17 APE12-dist-na 14.203 APE11-dist-na 9.884 APE10-dist-na 13.331 APE9-dist-in 7.722 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.5 0.176 0.194 A 327 288 0 0 0 0 [[589, 926]] 1.0 8pqd Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8PQDB P10721 566 932 976.0 9VV:61001 Type1 Active DFGin 7.317 13.736 BLAminus -126.15, 174.7 62.73, 89.5 -101.98, 24.1 285.73, 74.08 -62.53, -30.1 in-in in 7.895 Saltbr-in 2.739 HRD-in -94.72, -44.07 75.73, -0.04 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.84, 140.68 APE9-dihe-in -121.78, 149.74 APE8-dihe-in -83.35, 71.92 APE8-rot-na 35.81 APE67-dihe-in -69.81, -8.26 -54.26, -45.11 APE12-dist-na 14.108 APE11-dist-na 9.808 APE10-dist-na 13.067 APE9-dist-in 7.689 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.5 0.176 0.194 B 327 289 0 0 0 0 [[589, 926]] 1.0 8pqd Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8PQFA P10721 566 931 976.0 9KI:61001 Type1 Active DFGin 7.014 14.115 BLAminus -129.63, 178.86 58.56, 84.18 -100.12, 27.12 285.56, 70.86 -63.9, -31.9 in-in in 8.201 Saltbr-in 2.803 HRD-in -89.02, -45.2 77.26, -1.95 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.18, 135.2 APE9-dihe-in -119.42, 150.13 APE8-dihe-in -82.55, 76.11 APE8-rot-na 32.82 APE67-dihe-in -71.08, -6.74 -56.61, -43.88 APE12-dist-na 14.104 APE11-dist-na 9.535 APE10-dist-na 12.742 APE9-dist-in 7.584 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.9 0.197 0.219 A 327 285 3 0 0 2 [[589, 926]] 1.0 8pqf Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8PQFC P10721 566 932 976.0 9KI:61001 Type1 Active DFGin 7.029 13.734 BLAminus -130.97, -177.27 58.3, 84.55 -100.6, 29.27 285.15, 69.87 -63.54, -39.98 in-in in 8.063 Saltbr-in 2.85 HRD-in -83.32, -44.04 70.24, 3.72 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.35, 134.14 APE9-dihe-in -127.54, 151.09 APE8-dihe-in -80.47, 79.59 APE8-rot-na 32.02 APE67-dihe-in -71.78, -11.06 -58.34, -43.23 APE12-dist-na 13.926 APE11-dist-na 8.992 APE10-dist-na 11.808 APE9-dist-in 7.23 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.9 0.197 0.219 C 327 287 2 0 0 2 [[589, 926]] 1.0 8pqf Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8S19A P10721 566 931 976.0 STU:61001 Type1 Active DFGin 7.404 13.667 BLAminus -127.12, -176.58 57.62, 86.03 -104.33, 27.64 287.94, 75.89 -65.62, -32.19 in-in in 8.528 Saltbr-in 2.807 HRD-in -86.95, -44.99 76.04, 4.46 in-in-in SNCiii in-in ActLoopNT-in 2.98 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.78, 135.36 APE9-dihe-in -116.81, 146.55 APE8-dihe-in -80.8, 82.76 APE8-rot-na 31.59 APE67-dihe-in -71.09, -10.53 -60.41, -40.84 APE12-dist-na 14.65 APE11-dist-na 10.007 APE10-dist-na 13.468 APE9-dist-in 7.899 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.3 0.186 0.208 A 327 287 1 0 0 1 [[589, 926]] 1.0 8s19 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8S19B P10721 566 930 976.0 STU:61001 Type1 Active DFGin 7.327 13.538 BLAminus -128.07, -176.35 62.24, 79.08 -101.65, 27.17 286.46, 78.41 -65.78, -31.3 in-in in 8.424 Saltbr-in 3.244 HRD-in -86.63, -46.82 74.21, 3.84 in-in-in SNCiii in-in ActLoopNT-in 2.972 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.88, 148.22 APE9-dihe-in -128.01, 146.9 APE8-dihe-in -81.2, 79.5 APE8-rot-na 31.77 APE67-dihe-in -74.43, -9.18 -60.72, -38.08 APE12-dist-na 14.121 APE11-dist-na 10.132 APE10-dist-na 13.229 APE9-dist-in 7.695 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.3 0.186 0.208 B 327 284 3 0 0 0 [[589, 926]] 1.0 8s19 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8S1AA P10721 565 931 976.0 6T2:61001 Type1 Active DFGin 7.481 13.454 BLAminus -130.25, 174.66 66.24, 93.25 -105.72, 18.63 285.4, 75.09 -61.16, -30.32 in-in in 8.321 Saltbr-in 3.005 HRD-in -89.71, -45.27 75.21, -0.98 in-in-in SNCiii in-in ActLoopNT-in 2.851 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.31, 143.6 APE9-dihe-in -122.04, 151.68 APE8-dihe-in -82.91, 74.45 APE8-rot-na 35.68 APE67-dihe-in -72.93, -9.14 -57.9, -42.62 APE12-dist-na 13.94 APE11-dist-na 9.499 APE10-dist-na 12.956 APE9-dist-in 7.584 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.85 0.188 0.208 A 327 286 3 0 0 0 [[589, 926]] 1.0 8s1a Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8S1AB P10721 566 931 976.0 6T2:61001 Type1 Active DFGin 7.432 13.564 BLAminus -134.77, 174.81 62.68, 90.66 -103.62, 20.87 285.06, 74.67 -61.54, -35.7 in-in in 8.31 Saltbr-in 2.716 HRD-in -95.21, -44.44 74.01, 0.64 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.03, 139.89 APE9-dihe-in -118.65, 149.04 APE8-dihe-in -82.35, 75.62 APE8-rot-na 34.69 APE67-dihe-in -73.13, -6.18 -57.98, -42.32 APE12-dist-na 14.151 APE11-dist-na 9.654 APE10-dist-na 13.127 APE9-dist-in 7.67 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.85 0.188 0.208 B 327 288 0 0 0 0 [[589, 926]] 1.0 8s1a Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 7KHKB P10721 567 929 976.0 WEJ:61001 Type1.5_Back Active DFGin 6.498 14.235 BLAminus -142.53, -172.25 54.51, 74.71 -95.93, 18.48 280.18, 76.12 -61.98, -36.28 in-in in 7.946 Saltbr-in 2.743 HRD-in -68.07, -48.48 77.89, -8.06 in-in-in SNCiii in-in ActLoopNT-in 3.029 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.55, 143.65 APE9-dihe-in -140.59, 157.12 APE8-dihe-in -84.72, 84.57 APE8-rot-na 30.89 APE67-dihe-in -62.7, -33.9 -56.2, -38.85 APE12-dist-na 14.303 APE11-dist-na 9.162 APE10-dist-na 11.383 APE9-dist-in 7.113 None None None XRAY 2.34 0.247 0.285 B 335 266 39 0 0 2 [[589, 926]] 1.0 7khk Homo sapiens TYR_KIT_HUMAN TYR 1.1e-104 355.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 1PKGA P10721 567 927 976.0 ADP:1480 ATPlike Inactive DFGin 6.481 14.136 BLAminus -130.56, -161.98 47.26, 79.76 -98.59, 34.29 290.92, 88.36 -71.71, -28.0 in-out in 8.138 Saltbr-out 3.883 HRD-in -70.61, -44.29 71.47, -6.33 out-in-out SNCoio in-out ActLoopNT-in 2.981 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 81.05, 87.98 APE9-dihe-in -123.34, 167.37 APE8-dihe-in -84.87, 64.98 APE8-rot-na 27.08 APE67-dihe-in -64.22, -13.25 -46.84, -45.75 APE12-dist-na 14.817 APE11-dist-na 9.099 APE10-dist-na 11.173 APE9-dist-in 6.894 None PTR568,PTR570 PTR568,PTR570 XRAY 2.9 0.229 0.311 A 329 292 11 0 0 0 [[589, 926]] 1.0 1pkg Homo sapiens TYR_KIT_HUMAN TYR 4.5e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8S13A P10721 554 931 976.0 No_ligand No_ligand Inactive DFGout 15.624 11.512 BBAminus -148.4, 169.24 -129.57, 102.72 -56.93, -44.81 289.47, 76.32 66.09, -124.48 in-none in 7.441 Saltbr-none 999.0 HRD-in -79.95, -50.64 76.82, -5.45 none-out-in SNCnoi out-in ActLoopNT-out 16.346 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.22, 120.12 APE9-dihe-in -133.85, 146.63 APE8-dihe-in -82.42, 75.57 APE8-rot-na 34.6 APE67-dihe-in -69.14, -10.54 -59.81, -43.07 APE12-dist-na 17.896 APE11-dist-na 15.835 APE10-dist-na 13.419 APE9-dist-in 7.636 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.0 0.206 0.236 A 327 291 6 0 0 0 [[589, 926]] 1.0 8s13 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8S14A P10721 554 931 976.0 B49:61001 Type1 Inactive DFGout 15.67 11.005 BBAminus -130.33, 156.75 -126.16, 102.94 -63.2, -39.5 274.42, 76.71 60.38, -127.64 in-in in 7.027 Saltbr-in 2.555 HRD-in -74.54, -47.39 71.57, -1.96 in-out-in SNCioi out-in ActLoopNT-out 16.165 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.13, 124.86 APE9-dihe-in -134.1, 147.98 APE8-dihe-in -82.5, 68.05 APE8-rot-na 34.36 APE67-dihe-in -70.91, -8.55 -58.2, -39.66 APE12-dist-na 17.889 APE11-dist-na 15.908 APE10-dist-na 13.814 APE9-dist-in 7.606 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.5 0.189 0.214 A 327 292 6 0 0 0 [[589, 926]] 1.0 8s14 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8S15A P10721 554 929 976.0 XIN:61001 Type1 Inactive DFGout 15.636 10.752 BBAminus -151.54, 167.1 -114.68, 111.91 -64.96, -34.32 269.42, 62.99 55.55, -112.33 in-in in 7.573 Saltbr-in 2.584 HRD-in -79.41, -46.95 68.95, -3.61 in-out-in SNCioi out-in ActLoopNT-out 15.753 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.59, 118.15 APE9-dihe-in -124.52, 145.08 APE8-dihe-in -74.65, 73.9 APE8-rot-na 30.34 APE67-dihe-in -67.28, -14.41 -59.06, -44.65 APE12-dist-na 17.811 APE11-dist-na 15.115 APE10-dist-na 13.124 APE9-dist-in 7.459 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.4 0.222 0.26 A 327 295 0 0 0 0 [[589, 926]] 1.0 8s15 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 3G0FA P10721 566 930 976.0 B49:9001 Type1 Inactive DFGout 15.932 11.024 BBAminus -133.24, 143.68 -91.38, 106.1 -85.13, 9.55 260.45, 86.5 -43.92, 131.31 in-in in 7.308 Saltbr-in 2.858 HRD-out -104.98, 124.53 -81.9, 0.65 in-out-in SNCioi out-in ActLoopNT-out 16.723 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.6, 122.46 APE9-dihe-in -125.81, 152.57 APE8-dihe-in -80.31, 82.53 APE8-rot-na 33.57 APE67-dihe-in -64.38, -18.09 -77.28, -33.89 APE12-dist-na 17.512 APE11-dist-na 13.756 APE10-dist-na 12.661 APE9-dist-in 7.497 D816H None None XRAY 2.6 0.212 0.255 A 336 291 16 0 0 0 [[589, 926]] 1.0 3g0f Homo sapiens TYR_KIT_HUMAN TYR 9.5e-102 346.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 3G0FB P10721 564 930 976.0 B49:9001 Type1 Inactive DFGout 16.025 10.608 BBAminus -141.97, 146.96 -100.97, 117.58 -98.35, 1.5 249.66, 85.76 -37.59, 131.92 in-in in 7.372 Saltbr-in 2.84 HRD-out -103.28, 116.42 -91.73, 18.13 in-out-in SNCioi out-in ActLoopNT-out 16.63 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.56, 113.86 APE9-dihe-in -119.17, 158.81 APE8-dihe-in -86.16, 69.24 APE8-rot-na 31.3 APE67-dihe-in -71.68, -15.15 -66.98, -25.93 APE12-dist-na 16.574 APE11-dist-na 13.473 APE10-dist-na 12.13 APE9-dist-in 7.192 D816H None None XRAY 2.6 0.212 0.255 B 336 293 16 0 0 0 [[589, 926]] 1.0 3g0f Homo sapiens TYR_KIT_HUMAN TYR 9.5e-102 346.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 7ZW8A P10721 554 932 976.0 K3R:1001 Type1 Inactive DFGout 16.012 10.018 BBAminus -138.08, -169.86 -159.78, 110.19 -64.11, -32.05 278.75, 82.59 52.03, -125.86 in-out in 7.721 Saltbr-out 4.364 HRD-in -61.49, -54.81 83.28, -7.92 out-out-in SNCooi out-in ActLoopNT-out 17.41 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.53, 117.94 APE9-dihe-in -118.58, 148.65 APE8-dihe-in -86.23, 67.89 APE8-rot-na 23.54 APE67-dihe-in -65.66, -17.01 -48.38, -44.77 APE12-dist-na 17.14 APE11-dist-na 12.852 APE10-dist-na 11.192 APE9-dist-in 7.887 None None None XRAY 2.119 0.212 0.25 A 327 301 14 0 0 0 [[589, 926]] 1.0 7zw8 Homo sapiens TYR_KIT_HUMAN TYR 4.4e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6KLAA P10721 554 931 976.0 DJX:1001 Type1 Inactive DFGout 16.031 10.495 BBAminus -144.54, -177.7 -136.39, 121.77 -66.88, -33.43 280.19, 83.19 48.43, -112.59 in-in in 7.464 Saltbr-in 3.119 HRD-in -76.38, -50.3 78.17, -9.51 in-out-in SNCioi out-in ActLoopNT-out 16.538 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.01, 114.36 APE9-dihe-in -126.31, 147.8 APE8-dihe-in -81.74, 73.59 APE8-rot-na 34.39 APE67-dihe-in -65.25, -12.32 -65.72, -36.43 APE12-dist-na 17.228 APE11-dist-na 13.724 APE10-dist-na 11.998 APE9-dist-in 7.869 None None None XRAY 2.109 0.187 0.224 A 331 309 9 0 0 0 [[589, 926]] 1.0 6kla Homo sapiens TYR_KIT_HUMAN TYR 4.6e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 4HVSA P10721 551 931 976.0 647:61001 Type2 Inactive DFGout 16.746 10.514 BBAminus -159.87, -170.23 -156.88, 107.58 -49.76, -38.8 288.82, 77.13 62.66, -117.3 in-in in 7.712 Saltbr-in 2.737 HRD-in -67.64, -52.36 77.34, -5.66 in-out-in SNCioi out-in ActLoopNT-out 17.051 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.37, 111.8 APE9-dihe-in -121.62, 137.52 APE8-dihe-in -74.22, 64.9 APE8-rot-na 31.15 APE67-dihe-in -65.92, -12.77 -54.47, -42.41 APE12-dist-na 16.871 APE11-dist-na 13.882 APE10-dist-na 11.234 APE9-dist-in 7.477 I563S,V569S,Y609Q,L631S,M651E,I662H,I690H,C691S,K693D,Q694T,E695S,I756S,L762N,V825D,C844S,L890S,L912D,L923D None None XRAY 1.9 0.2 0.227 A 335 323 0 0 0 0 [[589, 926]] 1.0 4hvs Homo sapiens TYR_KIT_HUMAN TYR 5e-105 356.5 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 7KHGA P10721 547 931 976.0 P31:61001 Type2 Inactive DFGout 16.792 10.534 BBAminus -158.09, -171.29 -155.8, 113.13 -53.22, -36.84 288.49, 77.89 59.09, -120.96 in-in in 7.674 Saltbr-in 2.792 HRD-in -71.24, -49.13 72.07, -2.92 in-out-in SNCioi out-in ActLoopNT-out 17.097 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.08, 109.74 APE9-dihe-in -119.45, 139.81 APE8-dihe-in -80.02, 70.33 APE8-rot-na 32.88 APE67-dihe-in -65.04, -11.31 -57.06, -45.0 APE12-dist-na 16.957 APE11-dist-na 13.892 APE10-dist-na 11.219 APE9-dist-in 7.602 None None None XRAY 2.15 0.184 0.203 A 335 327 0 0 0 0 [[589, 926]] 1.0 7khg Homo sapiens TYR_KIT_HUMAN TYR 5e-105 356.5 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8S16A P10721 566 932 976.0 STI:61001 Type2 Inactive DFGout 16.156 10.633 BBAminus -135.66, -175.47 -146.5, 109.21 -66.07, -39.1 278.01, 69.44 60.83, -124.1 in-in in 7.912 Saltbr-in 2.965 HRD-in -69.14, -53.88 78.27, -9.6 in-out-in SNCioi out-in ActLoopNT-out 16.021 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.16, 109.76 APE9-dihe-in -124.4, 150.42 APE8-dihe-in -79.68, 69.89 APE8-rot-na 33.56 APE67-dihe-in -69.51, -13.06 -61.98, -37.06 APE12-dist-na 16.436 APE11-dist-na 13.18 APE10-dist-na 11.121 APE9-dist-in 7.791 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.85 0.177 0.207 A 327 289 0 0 0 0 [[589, 926]] 1.0 8s16 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8S16B P10721 578 931 976.0 STI:61001 Type2 Inactive DFGout 15.888 10.523 BBAminus -137.35, -173.79 -154.74, 102.74 -60.21, -39.63 280.81, 66.69 55.03, -114.07 in-in in 7.842 Saltbr-in 2.853 HRD-in -70.27, -58.28 86.53, -13.22 in-out-in SNCioi out-in ActLoopNT-out 16.122 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.71, 104.25 APE9-dihe-in -123.97, 149.57 APE8-dihe-in -79.76, 65.91 APE8-rot-na 34.81 APE67-dihe-in -69.88, -14.71 -57.96, -38.02 APE12-dist-na 17.084 APE11-dist-na 13.899 APE10-dist-na 11.436 APE9-dist-in 7.91 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.85 0.177 0.207 B 327 276 0 0 0 0 [[589, 926]] 1.0 8s16 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8S17A P10721 567 931 976.0 0LI:61001 Type2 Inactive DFGout 15.425 9.951 BBAminus -145.25, 179.39 -143.98, 106.64 -67.34, -40.16 274.67, 96.68 58.73, -115.03 in-in in 7.749 Saltbr-in 2.696 HRD-in -73.68, -54.05 81.88, -13.47 in-out-in SNCioi out-in ActLoopNT-out 16.311 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.0, 112.95 APE9-dihe-in -124.02, 150.83 APE8-dihe-in -80.03, 74.01 APE8-rot-na 32.18 APE67-dihe-in -67.91, -14.83 -61.86, -40.28 APE12-dist-na 16.635 APE11-dist-na 13.202 APE10-dist-na 11.515 APE9-dist-in 7.701 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.2 0.203 0.228 A 327 287 0 0 0 0 [[589, 926]] 1.0 8s17 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8S17B P10721 578 931 976.0 0LI:61001 Type2 Inactive DFGout 15.227 9.879 BBAminus -145.11, 172.96 -138.62, 103.76 -65.65, -38.27 276.93, 92.02 61.53, -118.4 in-in in 7.652 Saltbr-in 2.743 HRD-in -69.78, -55.3 82.77, -9.47 in-out-in SNCioi out-in ActLoopNT-out 16.408 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.26, 116.47 APE9-dihe-in -128.18, 149.58 APE8-dihe-in -80.46, 72.63 APE8-rot-na 32.73 APE67-dihe-in -67.64, -17.39 -58.96, -38.89 APE12-dist-na 16.505 APE11-dist-na 13.309 APE10-dist-na 11.718 APE9-dist-in 7.975 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.2 0.203 0.228 B 327 276 0 0 0 0 [[589, 926]] 1.0 8s17 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8S18A P10721 568 931 976.0 A1H4U:61001 Type2 Inactive DFGout 14.358 9.846 BBAminus -136.5, 172.4 -143.71, 96.71 -74.26, -23.47 290.48, 134.1 43.91, -111.27 in-in in 7.768 Saltbr-in 2.833 HRD-in -78.51, -51.56 81.82, -15.01 in-out-in SNCioi out-in ActLoopNT-out 16.236 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.06, 109.89 APE9-dihe-in -125.76, 152.89 APE8-dihe-in -81.62, 69.52 APE8-rot-na 33.63 APE67-dihe-in -66.18, -17.82 -59.01, -39.86 APE12-dist-na 16.492 APE11-dist-na 13.102 APE10-dist-na 11.251 APE9-dist-in 7.774 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.1 0.194 0.218 A 327 286 0 0 0 0 [[589, 926]] 1.0 8s18 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8S18B P10721 578 931 976.0 A1H4U:61001 Type2 Inactive DFGout 14.108 9.476 BBAminus -139.33, 158.91 -137.25, 115.01 -87.55, -17.15 295.29, 118.72 51.85, -119.38 in-in in 7.955 Saltbr-in 2.767 HRD-in -75.32, -56.82 85.0, -9.46 in-out-in SNCioi out-in ActLoopNT-out 15.856 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.84, 113.28 APE9-dihe-in -126.85, 149.08 APE8-dihe-in -82.57, 70.64 APE8-rot-na 34.25 APE67-dihe-in -68.54, -17.43 -60.68, -37.6 APE12-dist-na 16.663 APE11-dist-na 13.374 APE10-dist-na 11.56 APE9-dist-in 7.778 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.1 0.194 0.218 B 327 276 0 0 0 0 [[589, 926]] 1.0 8s18 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6GQJA P10721 567 931 976.0 F82:1001 Type2 Inactive DFGout 15.431 9.8 BBAminus -136.14, -170.08 -155.16, 100.15 -61.78, -34.41 278.51, 89.29 45.55, -110.63 in-in in 7.709 Saltbr-in 2.785 HRD-in -67.68, -49.72 75.47, -12.89 in-out-in SNCioi out-in ActLoopNT-out 16.263 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.47, 103.38 APE9-dihe-in -113.89, 148.07 APE8-dihe-in -82.1, 66.48 APE8-rot-na 35.26 APE67-dihe-in -63.13, -15.01 -49.56, -44.22 APE12-dist-na 16.275 APE11-dist-na 13.067 APE10-dist-na 11.362 APE9-dist-in 7.977 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.33 0.183 0.217 A 327 298 6 0 0 0 [[589, 926]] 1.0 6gqj Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6GQJB P10721 572 931 976.0 F82:1001 Type2 Inactive DFGout 15.57 9.889 BBAminus -134.09, -172.42 -152.78, 100.31 -60.59, -34.13 279.05, 88.45 48.2, -115.16 in-in in 7.673 Saltbr-in 2.774 HRD-in -74.21, -50.69 79.42, -13.47 in-out-in SNCioi out-in ActLoopNT-out 16.241 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.62, 102.98 APE9-dihe-in -113.69, 149.0 APE8-dihe-in -85.17, 67.73 APE8-rot-na 33.45 APE67-dihe-in -61.65, -16.27 -50.45, -44.13 APE12-dist-na 16.643 APE11-dist-na 13.355 APE10-dist-na 11.507 APE9-dist-in 7.985 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.33 0.183 0.217 B 327 292 7 0 0 0 [[589, 926]] 1.0 6gqj Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6GQKA P10721 567 931 976.0 F88:61001 Type2 Inactive DFGout 16.265 10.54 BBAminus -138.36, -179.35 -150.62, 102.51 -62.45, -32.35 276.39, 87.37 49.32, -117.03 in-in in 7.663 Saltbr-in 3.188 HRD-in -73.61, -52.81 79.41, -11.37 in-out-out SNCioo out-out ActLoopNT-out 16.465 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -119.95, 100.35 APE9-dihe-in -115.33, 151.26 APE8-dihe-in -84.45, 66.8 APE8-rot-na 34.27 APE67-dihe-in -66.19, -12.65 -48.04, -43.77 APE12-dist-na 16.94 APE11-dist-na 13.676 APE10-dist-na 11.702 APE9-dist-out 8.021 I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.31 0.188 0.22 A 328 282 0 0 0 0 [[589, 926]] 1.0 6gqk Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6GQKB P10721 572 931 976.0 F88:61001 Type2 Inactive DFGout 16.311 10.572 BBAminus -138.21, -178.47 -152.96, 103.82 -61.94, -32.56 277.07, 85.37 50.17, -117.95 in-in in 7.649 Saltbr-in 3.206 HRD-in -72.76, -53.71 79.41, -11.08 in-out-out SNCioo out-out ActLoopNT-out 16.384 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -116.06, 104.54 APE9-dihe-in -119.72, 151.19 APE8-dihe-in -85.12, 66.24 APE8-rot-na 33.44 APE67-dihe-in -66.35, -13.84 -47.54, -43.83 APE12-dist-na 17.282 APE11-dist-na 13.998 APE10-dist-na 11.892 APE9-dist-out 8.091 I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.31 0.188 0.22 B 328 277 0 0 0 0 [[589, 926]] 1.0 6gqk Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6GQLA P10721 568 931 976.0 F8B:61001 Type2 Inactive DFGout 16.298 10.407 BBAminus -139.81, -179.58 -147.15, 104.1 -62.76, -35.23 278.0, 81.24 49.83, -115.81 in-in in 7.688 Saltbr-in 2.702 HRD-in -69.78, -53.4 80.29, -13.23 in-out-in SNCioi out-in ActLoopNT-out 16.604 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.57, 101.18 APE9-dihe-in -117.98, 151.43 APE8-dihe-in -83.84, 67.65 APE8-rot-na 33.5 APE67-dihe-in -63.86, -15.23 -50.06, -43.24 APE12-dist-na 16.889 APE11-dist-na 13.629 APE10-dist-na 11.418 APE9-dist-in 7.998 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.01 0.202 0.222 A 328 297 6 0 0 0 [[589, 926]] 1.0 6gql Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6GQLB P10721 577 931 976.0 F8B:61001 Type2 Inactive DFGout 16.337 10.478 BBAminus -138.32, -179.86 -148.07, 104.2 -62.14, -34.67 277.43, 81.68 50.68, -116.78 in-in in 7.731 Saltbr-in 2.741 HRD-in -68.79, -54.39 79.8, -13.05 in-out-out SNCioo out-out ActLoopNT-out 16.537 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -117.3, 101.37 APE9-dihe-in -120.57, 151.18 APE8-dihe-in -84.13, 66.79 APE8-rot-na 32.76 APE67-dihe-in -64.17, -15.21 -49.48, -43.05 APE12-dist-na 17.164 APE11-dist-na 13.913 APE10-dist-na 11.519 APE9-dist-out 8.06 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.01 0.202 0.222 B 328 286 8 0 0 0 [[589, 926]] 1.0 6gql Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6GQMA P10721 569 931 976.0 F8H:61001 Type2 Inactive DFGout 16.229 10.388 BBAminus -136.57, -179.47 -147.93, 100.03 -59.52, -34.87 275.16, 81.94 48.12, -112.93 in-in in 7.556 Saltbr-in 2.756 HRD-in -68.29, -51.8 77.27, -17.33 in-out-in SNCioi out-in ActLoopNT-out 16.474 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.29, 100.87 APE9-dihe-in -115.89, 146.45 APE8-dihe-in -80.79, 61.87 APE8-rot-na 34.09 APE67-dihe-in -66.61, -10.92 -45.17, -44.75 APE12-dist-na 16.602 APE11-dist-na 13.143 APE10-dist-na 11.005 APE9-dist-in 7.881 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.0 0.205 0.23 A 328 296 6 0 0 0 [[589, 926]] 1.0 6gqm Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6GQMB P10721 577 931 976.0 F8H:61001 Type2 Inactive DFGout 16.208 10.398 BBAminus -135.72, -179.99 -147.49, 100.7 -59.32, -34.43 274.81, 80.92 50.64, -114.3 in-in in 7.55 Saltbr-in 2.759 HRD-in -67.84, -52.64 77.31, -15.84 in-out-in SNCioi out-in ActLoopNT-out 16.418 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.68, 94.89 APE9-dihe-in -113.11, 150.6 APE8-dihe-in -84.09, 61.58 APE8-rot-na 33.61 APE67-dihe-in -66.61, -10.94 -43.73, -45.44 APE12-dist-na 16.946 APE11-dist-na 13.535 APE10-dist-na 11.221 APE9-dist-in 7.933 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.0 0.205 0.23 B 328 288 6 0 0 0 [[589, 926]] 1.0 6gqm Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6XV9A P10721 566 931 976.0 O35:61001 Type2 Inactive DFGout 15.543 9.748 BBAminus -131.58, -169.39 -156.72, 93.49 -62.05, -42.03 282.46, 88.43 48.41, -104.01 in-in in 7.689 Saltbr-in 2.832 HRD-in -69.28, -49.38 72.93, -5.84 in-out-in SNCioi out-in ActLoopNT-out 16.311 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.37, 97.09 APE9-dihe-in -112.0, 148.71 APE8-dihe-in -81.81, 67.27 APE8-rot-na 29.88 APE67-dihe-in -63.86, -9.66 -46.65, -44.91 APE12-dist-na 16.579 APE11-dist-na 13.135 APE10-dist-na 10.916 APE9-dist-in 7.629 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 3.38 0.197 0.247 A 328 288 0 0 0 0 [[589, 926]] 1.0 6xv9 Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6XV9B P10721 572 931 976.0 O35:61001 Type2 Inactive DFGout 15.678 9.77 BBAminus -131.94, -171.98 -157.03, 93.9 -61.83, -41.64 282.16, 88.18 48.65, -104.6 in-in in 7.733 Saltbr-in 2.854 HRD-in -68.86, -49.09 75.5, -9.43 in-out-in SNCioi out-in ActLoopNT-out 16.206 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.51, 98.6 APE9-dihe-in -113.58, 149.31 APE8-dihe-in -82.14, 67.2 APE8-rot-na 30.55 APE67-dihe-in -64.65, -9.32 -46.19, -45.23 APE12-dist-na 16.763 APE11-dist-na 13.334 APE10-dist-na 11.149 APE9-dist-in 7.755 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 3.38 0.197 0.247 B 328 282 0 0 0 0 [[589, 926]] 1.0 6xv9 Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6XVAA P10721 569 931 976.0 O2K:61001 Type2 Inactive DFGout 15.552 9.873 BBAminus -130.9, -166.53 -160.13, 95.6 -61.57, -39.69 279.99, 84.81 51.06, -112.95 in-in in 7.671 Saltbr-in 2.812 HRD-in -65.74, -44.71 75.29, -12.36 in-out-in SNCioi out-in ActLoopNT-out 16.456 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.89, 95.77 APE9-dihe-in -112.54, 151.67 APE8-dihe-in -83.56, 70.47 APE8-rot-na 31.96 APE67-dihe-in -64.92, -13.68 -47.25, -45.59 APE12-dist-na 16.25 APE11-dist-na 13.101 APE10-dist-na 11.187 APE9-dist-in 7.904 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.3 0.198 0.245 A 328 285 0 0 0 0 [[589, 926]] 1.0 6xva Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6XVAB P10721 577 931 976.0 O2K:61001 Type2 Inactive DFGout 15.832 9.946 BBAminus -129.58, -168.14 -159.52, 95.6 -60.13, -40.05 280.9, 81.98 51.8, -114.7 in-in in 7.838 Saltbr-in 2.873 HRD-in -67.63, -49.04 76.72, -12.76 in-out-in SNCioi out-in ActLoopNT-out 16.3 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.1, 96.88 APE9-dihe-in -113.3, 152.94 APE8-dihe-in -84.37, 70.57 APE8-rot-na 30.8 APE67-dihe-in -65.41, -13.28 -47.31, -45.65 APE12-dist-na 16.527 APE11-dist-na 13.148 APE10-dist-na 11.354 APE9-dist-in 7.935 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.3 0.198 0.245 B 328 277 0 0 0 0 [[589, 926]] 1.0 6xva Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6XVBA P10721 569 931 976.0 O2H:61001 Type2 Inactive DFGout 15.696 10.02 BBAminus -139.93, -171.17 -149.97, 98.79 -62.06, -36.15 280.7, 79.89 52.82, -116.74 in-in in 7.626 Saltbr-in 2.776 HRD-in -70.55, -51.81 77.37, -9.25 in-out-in SNCioi out-in ActLoopNT-out 16.539 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.91, 97.58 APE9-dihe-in -112.95, 149.34 APE8-dihe-in -83.11, 69.81 APE8-rot-na 31.26 APE67-dihe-in -62.03, -20.02 -53.33, -41.4 APE12-dist-na 16.854 APE11-dist-na 13.597 APE10-dist-na 11.232 APE9-dist-in 7.817 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.15 0.194 0.223 A 328 285 0 0 0 0 [[589, 926]] 1.0 6xvb Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6XVBB P10721 577 931 976.0 O2H:61001 Type2 Inactive DFGout 15.815 10.031 BBAminus -139.72, -172.06 -151.07, 100.84 -60.77, -37.85 279.63, 78.82 52.08, -117.31 in-in in 7.634 Saltbr-in 2.778 HRD-in -66.84, -49.22 76.63, -10.21 in-out-in SNCioi out-in ActLoopNT-out 16.489 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.62, 98.9 APE9-dihe-in -115.12, 149.29 APE8-dihe-in -83.95, 69.91 APE8-rot-na 30.96 APE67-dihe-in -63.32, -19.92 -52.16, -41.56 APE12-dist-na 16.981 APE11-dist-na 13.768 APE10-dist-na 11.259 APE9-dist-in 7.864 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.15 0.194 0.223 B 328 277 0 0 0 0 [[589, 926]] 1.0 6xvb Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.2 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6HH1A P10721 565 929 976.0 G4E:61002 Type2 Inactive DFGout 14.661 10.012 BBAminus -138.92, -176.56 -149.27, 99.83 -51.66, -24.64 274.87, 97.82 33.16, -115.44 in-in in 7.308 Saltbr-in 2.465 HRD-none 999.0, 999.0 999.0, 999.0 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_iiiai APEdist_aaan APE10-dihe-in -111.15, 108.76 APE9-dihe-in -124.6, 151.33 APE8-dihe-in -84.01, 72.22 APE8-rot-na 35.73 APE67-dihe-in -67.14, -12.3 -57.73, -41.96 APE12-dist-na 17.197 APE11-dist-na 14.167 APE10-dist-na 11.999 APE9-dist-none 999.0 None None None XRAY 2.25 0.208 0.273 A 303 266 0 0 0 0 [[589, 926]] 1.0 6hh1 Homo sapiens TYR_KIT_HUMAN TYR 3.1e-102 347.3 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6MOBA P10721 567 930 976.0 JWY:61015 Type2 Inactive DFGout 15.878 11.579 BBAminus -127.84, 149.97 -94.24, 110.85 -86.58, 15.01 261.63, 78.66 -55.34, 145.08 in-in in 6.702 Saltbr-in 2.873 HRD-in -79.72, -39.78 69.39, 0.84 in-out-in SNCioi out-in ActLoopNT-out 17.191 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.68, 117.19 APE9-dihe-in -127.37, 145.81 APE8-dihe-in -81.12, 64.9 APE8-rot-na 36.53 APE67-dihe-in -63.81, -14.22 -53.22, -40.55 APE12-dist-na 19.237 APE11-dist-na 15.935 APE10-dist-na 13.719 APE9-dist-in 7.891 None None None XRAY 1.8 0.183 0.21 A 312 304 0 0 0 0 [[589, 926]] 1.0 6mob Homo sapiens TYR_KIT_HUMAN TYR 3.7e-102 347.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 1T46A P10721 565 933 976.0 STI:3 Type2 Inactive DFGout 15.698 10.154 BBAminus -131.86, -173.06 -155.36, 102.8 -61.56, -32.02 275.6, 68.14 52.41, -121.03 in-in in 7.777 Saltbr-in 2.635 HRD-in -73.88, -54.0 82.13, -17.12 in-out-in SNCioi out-in ActLoopNT-out 15.995 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.78, 112.21 APE9-dihe-in -122.06, 148.23 APE8-dihe-in -76.99, 63.4 APE8-rot-na 27.97 APE67-dihe-in -65.29, -14.58 -53.78, -42.45 APE12-dist-na 17.358 APE11-dist-na 13.86 APE10-dist-na 12.062 APE9-dist-in 7.881 None None None XRAY 1.6 0.19 0.213 A 313 297 14 0 0 0 [[589, 926]] 1.0 1t46 Homo sapiens TYR_KIT_HUMAN TYR 3.7e-102 347.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 4U0IA P10721 565 933 976.0 0LI:1001 Type2 Inactive DFGout 15.152 9.758 BBAminus -145.62, -174.19 -155.03, 115.98 -76.91, -26.31 285.47, 90.73 51.17, -116.44 in-in in 7.686 Saltbr-in 2.619 HRD-in -74.87, -53.81 79.28, -20.01 in-out-in SNCioi out-in ActLoopNT-out 16.446 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.86, 120.83 APE9-dihe-in -126.16, 149.12 APE8-dihe-in -78.54, 70.26 APE8-rot-na 32.2 APE67-dihe-in -61.59, -16.21 -59.65, -43.09 APE12-dist-na 17.193 APE11-dist-na 14.015 APE10-dist-na 12.164 APE9-dist-in 7.681 None None None XRAY 2.0 0.204 0.239 A 315 297 12 0 0 0 [[589, 926]] 1.0 4u0i Homo sapiens TYR_KIT_HUMAN TYR 3.8e-102 347.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 7ZY6A P10721 557 932 976.0 KCI:1001 Type2 Inactive DFGout 16.172 10.316 BBAminus -136.78, -169.12 -153.88, 112.67 -67.2, -49.87 280.18, 88.12 64.42, -125.84 in-out in 7.505 Saltbr-out 3.808 HRD-in -58.49, -51.37 72.91, -7.18 out-out-in SNCooi out-in ActLoopNT-out 16.646 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.67, 123.05 APE9-dihe-in -122.6, 151.66 APE8-dihe-in -82.55, 76.06 APE8-rot-na 28.18 APE67-dihe-in -56.34, -24.16 -50.87, -51.7 APE12-dist-na 16.893 APE11-dist-na 12.279 APE10-dist-na 11.342 APE9-dist-in 7.708 None None None XRAY 3.09 0.226 0.298 A 327 293 15 0 0 0 [[589, 926]] 1.0 7zy6 Homo sapiens TYR_KIT_HUMAN TYR 4.4e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6ITTA P10721 563 932 976.0 AWO:1001 Type2 Inactive DFGout 15.484 9.996 BBAminus -135.32, -179.43 -142.96, 106.16 -65.75, -31.61 273.13, 95.47 52.92, -118.06 in-in in 7.514 Saltbr-in 2.417 HRD-in -74.63, -52.97 82.44, -12.98 in-out-in SNCioi out-in ActLoopNT-out 16.302 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.45, 111.43 APE9-dihe-in -126.25, 147.19 APE8-dihe-in -79.48, 66.78 APE8-rot-na 33.6 APE67-dihe-in -70.79, -15.46 -52.73, -40.71 APE12-dist-na 16.642 APE11-dist-na 13.251 APE10-dist-na 11.298 APE9-dist-in 7.826 None None None XRAY 2.103 0.188 0.235 A 331 301 9 0 0 0 [[589, 926]] 1.0 6itt Homo sapiens TYR_KIT_HUMAN TYR 4.6e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6ITTB P10721 566 932 976.0 AWO:1001 Type2 Inactive DFGout 15.854 9.954 BBAminus -133.07, -166.83 -157.39, 107.5 -64.33, -24.78 281.52, 85.55 48.34, -114.87 in-in in 7.396 Saltbr-in 2.812 HRD-in -77.26, -52.35 84.78, -20.38 in-out-in SNCioi out-in ActLoopNT-out 16.43 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.43, 115.97 APE9-dihe-in -124.11, 147.19 APE8-dihe-in -79.93, 68.79 APE8-rot-na 32.78 APE67-dihe-in -67.26, -20.31 -62.0, -32.62 APE12-dist-na 16.358 APE11-dist-na 12.759 APE10-dist-na 11.539 APE9-dist-in 7.721 None None None XRAY 2.103 0.188 0.235 B 331 297 10 0 0 0 [[589, 926]] 1.0 6itt Homo sapiens TYR_KIT_HUMAN TYR 4.6e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 6ITVA P10721 569 935 976.0 AWO:1001 Type2 Inactive DFGout 15.681 9.968 BBAminus -133.58, -176.04 -147.68, 101.18 -63.17, -35.25 275.27, 92.64 59.41, -120.81 in-in in 7.242 Saltbr-in 2.692 HRD-in -77.36, -52.7 81.42, -8.84 in-out-in SNCioi out-in ActLoopNT-out 16.359 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.69, 111.08 APE9-dihe-in -117.38, 154.04 APE8-dihe-in -83.08, 69.5 APE8-rot-na 33.4 APE67-dihe-in -64.37, -14.12 -61.67, -38.34 APE12-dist-na 16.4 APE11-dist-na 12.492 APE10-dist-na 11.609 APE9-dist-in 7.771 None PTR570 PTR570 XRAY 1.881 0.183 0.231 A 331 298 9 0 0 0 [[589, 926]] 1.0 6itv Homo sapiens TYR_KIT_HUMAN TYR 4.6e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8S1BB P10721 565 930 976.0 K3R:61001,K3R:61002,K3R:61003 Type2,Allosteric,Allosteric Inactive DFGout 16.169 10.058 BBAminus -146.83, -168.87 -158.96, 107.65 -65.61, -37.38 279.44, 81.29 53.58, -115.98 in-out in 7.801 Saltbr-out 4.493 HRD-in -74.79, -50.48 79.07, -8.17 out-out-in SNCooi out-in ActLoopNT-out 16.848 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.82, 139.49 APE9-dihe-in -122.28, 148.41 APE8-dihe-in -81.66, 77.14 APE8-rot-na 32.23 APE67-dihe-in -70.9, -9.09 -57.75, -42.87 APE12-dist-na 999.0 APE11-dist-na 12.33 APE10-dist-na 11.01 APE9-dist-in 7.722 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.0 0.204 0.231 B 327 275 13 0 0 13 [[589, 926]] 1.0 8s1b Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 1T45A P10721 547 935 976.0 No_ligand No_ligand Inactive DFGout 15.995 8.618 None -149.03, -178.26 -114.33, 114.95 -104.67, 13.77 216.67, 60.33 -60.17, -31.26 in-in in 7.335 Saltbr-in 2.644 HRD-in -82.54, -46.77 73.44, -10.98 in-out-in SNCioi out-in ActLoopNT-out 17.676 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.95, 120.89 APE9-dihe-in -128.42, 148.93 APE8-dihe-in -80.27, 68.64 APE8-rot-na 34.24 APE67-dihe-in -66.94, -15.67 -58.16, -36.35 APE12-dist-na 19.181 APE11-dist-na 14.984 APE10-dist-na 13.176 APE9-dist-in 7.698 None None None XRAY 1.9 0.194 0.222 A 331 331 0 0 0 0 [[589, 926]] 1.0 1t45 Homo sapiens TYR_KIT_HUMAN TYR 4.6e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 3G0EA P10721 544 931 976.0 B49:69000 Type1 Inactive DFGout 17.746 11.185 None -121.33, 151.46 -96.26, 99.11 -97.45, -2.26 201.86, 86.92 -50.22, -44.62 in-in in 7.975 Saltbr-in 2.741 HRD-in -84.75, -49.91 86.53, -14.09 in-out-in SNCioi out-in ActLoopNT-out 17.007 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.72, 116.38 APE9-dihe-in -130.06, 149.91 APE8-dihe-in -78.23, 61.24 APE8-rot-na 30.2 APE67-dihe-in -67.26, -15.34 -60.23, -32.65 APE12-dist-na 20.171 APE11-dist-na 16.418 APE10-dist-na 14.346 APE9-dist-in 7.896 None None None XRAY 1.6 0.201 0.212 A 336 330 0 0 0 0 [[589, 926]] 1.0 3g0e Homo sapiens TYR_KIT_HUMAN TYR 4.8e-102 347.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8S1BA P10721 565 931 976.0 K3R:61001 Type2 Inactive DFGout 16.161 9.934 None -141.28, -177.54 -152.15, 111.48 -76.48, 999.0 278.29, 104.57 999.0, 999.0 in-in in 8.01 Saltbr-in 2.953 HRD-in -83.54, -49.08 76.6, -0.94 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.56, 134.6 APE9-dihe-in -124.31, 149.97 APE8-dihe-in -81.72, 80.43 APE8-rot-na 31.68 APE67-dihe-in -72.23, -10.16 -60.27, -44.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.579 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.0 0.204 0.231 A 327 269 20 0 0 17 [[589, 926]] 1.0 8s1b Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8PQEA P10721 566 930 976.0 9WU:61002 Type1 Inactive None 999.0 999.0 None -123.65, 163.55 59.33, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.376 Saltbr-in 2.852 HRD-in -77.67, -50.66 77.73, -6.13 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -38.37 APE9-dihe-in -124.18, 149.41 APE8-dihe-in -83.4, 76.76 APE8-rot-na 31.5 APE67-dihe-in -70.67, -10.1 -55.54, -43.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.661 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.0 0.216 0.256 A 327 267 20 0 0 19 [[589, 926]] 1.0 8pqe Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 1PKGB P10721 566 929 976.0 ADP:1486 ATPlike None DFGin 6.537 13.819 BLAminus -133.94, -165.75 57.9, 93.59 -119.64, 36.22 290.23, 87.19 -80.39, -20.36 in-in in 6.934 Saltbr-in 2.915 HRD-in -72.14, -51.55 69.69, 17.19 in-in-none SNCiin in-none ActLoopNT-in 2.888 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 110.55 APE9-dihe-in -141.29, 162.93 APE8-dihe-in -80.26, 78.25 APE8-rot-na 29.66 APE67-dihe-in -62.74, -24.13 -40.98, -43.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.765 APE9-dist-in 6.494 None PTR568,PTR570 PTR568,PTR570 XRAY 2.9 0.229 0.311 B 329 279 27 0 0 13 [[589, 926]] 1.0 1pkg Homo sapiens TYR_KIT_HUMAN TYR 4.5e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8PQBA P10721 567 931 976.0 9XO:61001 Type1 None DFGin 7.065 13.907 BLAminus -125.03, 178.92 57.85, 86.74 -99.85, 27.47 283.64, 67.72 -68.32, -23.51 in-in in 7.946 Saltbr-in 2.834 HRD-in -88.64, -44.33 73.75, -0.94 in-in-none SNCiin in-none ActLoopNT-in 2.88 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -36.37 APE9-dihe-in -123.05, 142.81 APE8-dihe-in -78.63, 73.9 APE8-rot-na 33.79 APE67-dihe-in -70.48, -9.16 -54.85, -42.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.094 APE9-dist-in 7.446 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.87 0.2 0.234 A 327 270 17 0 0 11 [[589, 926]] 1.0 8pqb Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
KIT_HUMAN 8PQEB P10721 566 930 976.0 9WU:61001 Type1 None DFGin 7.234 14.115 BLAminus -126.18, 173.65 61.69, 86.72 -98.88, 21.32 288.15, 71.07 -45.22, -42.17 in-in in 8.62 Saltbr-in 3.312 HRD-in -77.31, -50.57 76.99, -5.36 in-in-none SNCiin in-none ActLoopNT-in 2.779 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 124.75 APE9-dihe-in -123.1, 151.69 APE8-dihe-in -82.48, 77.97 APE8-rot-na 31.45 APE67-dihe-in -69.72, -10.62 -57.01, -43.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.159 APE9-dist-in 7.513 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.0 0.216 0.256 B 327 274 13 0 0 13 [[589, 926]] 1.0 8pqe Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit

TYR_KIT (Mast/stem cell growth factor receptor Kit)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name