Ligand

Protein kinases in complex with 6GY (Brigatinib)

Total number of genes: 2

Total number of chains: 4

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	3	8H7XA
DFGin	ABAminus	1	6MX8A

Database table as tsv

Group	Gene	UniprotID	Protein	PDB	Resolu	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type
TYR	ALK	ALK_HUMAN	ALK tyrosine kinase receptor	6MX8A	1.96	Inactive	DFGin	ABAminus	in-in	none-out	6GY	Type1
TYR	EGFR	EGFR_HUMAN	Epidermal growth factor receptor	8H7XA	3.404	Active	DFGin	BLAminus	in-in	in-in	6GY	Type1
TYR	EGFR	EGFR_HUMAN	Epidermal growth factor receptor	7ZYMA	2.5	Active	DFGin	BLAminus	in-in	in-in	6GY	Type1
TYR	EGFR	EGFR_HUMAN	Epidermal growth factor receptor	7AEMA	2.65	Active	DFGin	BLAminus	in-in	in-in	6GY	Type1

Protein kinases in complex with 6GY

Total number of genes: 2

Total number of chains: 4

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	3	8H7XA
DFGin	ABAminus	1	6MX8A

Database table as tsv

Organism	Group	Gene	UniprotID	Protein	PDB	Resolu	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type
Homo sapiens	TYR	ALK	ALK_HUMAN	ALK tyrosine kinase receptor	6MX8A	1.96	Inactive	DFGin	ABAminus	in-in	none-out	6GY	Type1
Homo sapiens	TYR	EGFR	EGFR_HUMAN	Epidermal growth factor receptor	8H7XA	3.404	Active	DFGin	BLAminus	in-in	in-in	6GY	Type1
Homo sapiens	TYR	EGFR	EGFR_HUMAN	Epidermal growth factor receptor	7ZYMA	2.5	Active	DFGin	BLAminus	in-in	in-in	6GY	Type1
Homo sapiens	TYR	EGFR	EGFR_HUMAN	Epidermal growth factor receptor	7AEMA	2.65	Active	DFGin	BLAminus	in-in	in-in	6GY	Type1

Protein kinases in complex with 6GY

Total number of genes: 0

Total number of chains: 0

Spatial	Dihedral	Chains	Representative

Database table as tsv

Organism	Group	Gene	UniprotID	Protein	PDB	Resolu	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type