Protein kinases in complex with 5P8 (Lorlatinib)

Total number of genes: 2
Total number of chains: 6
Spatial Dihedral Chains Representative
DFGin ABAminus 6 4UXLA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
TYR ALK ALK_HUMAN ALK tyrosine kinase receptor 4CLJA 1.66 Inactive DFGin ABAminus in-in out-in 5P8 Type1
TYR ALK ALK_HUMAN ALK tyrosine kinase receptor 5AA9A 1.93 Inactive DFGin ABAminus in-out out-out 5P8 Type1
TYR ALK ALK_HUMAN ALK tyrosine kinase receptor 5AA8A 1.86 Inactive DFGin ABAminus in-out out-out 5P8 Type1
TYR ALK ALK_HUMAN ALK tyrosine kinase receptor 4CLIA 2.05 Inactive DFGin ABAminus in-out out-in 5P8 Type1
TYR ALK ALK_HUMAN ALK tyrosine kinase receptor 5A9UA 1.6 Inactive DFGin ABAminus in-out out-out 5P8 Type1
TYR ROS1 ROS1_HUMAN Proto-oncogene tyrosine-protein kinase ROS 4UXLA 2.4 Inactive DFGin ABAminus in-out in-out 5P8 Type1

Protein kinases in complex with 5P8

Total number of genes: 2
Total number of chains: 6
Spatial Dihedral Chains Representative
DFGin ABAminus 6 4UXLA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens TYR ALK ALK_HUMAN ALK tyrosine kinase receptor 4CLJA 1.66 Inactive DFGin ABAminus in-in out-in 5P8 Type1
Homo sapiens TYR ALK ALK_HUMAN ALK tyrosine kinase receptor 5AA9A 1.93 Inactive DFGin ABAminus in-out out-out 5P8 Type1
Homo sapiens TYR ALK ALK_HUMAN ALK tyrosine kinase receptor 5AA8A 1.86 Inactive DFGin ABAminus in-out out-out 5P8 Type1
Homo sapiens TYR ALK ALK_HUMAN ALK tyrosine kinase receptor 4CLIA 2.05 Inactive DFGin ABAminus in-out out-in 5P8 Type1
Homo sapiens TYR ALK ALK_HUMAN ALK tyrosine kinase receptor 5A9UA 1.6 Inactive DFGin ABAminus in-out out-out 5P8 Type1
Homo sapiens TYR ROS1 ROS1_HUMAN Proto-oncogene tyrosine-protein kinase ROS 4UXLA 2.4 Inactive DFGin ABAminus in-out in-out 5P8 Type1

Protein kinases in complex with 5P8

Total number of genes: 0
Total number of chains: 0
Spatial Dihedral Chains Representative
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type