TYR_ALK (ALK tyrosine kinase receptor)

Total number of chains: 68
Active chains: 2
Uniprot: ALK_HUMAN
Kinase Domain Residues: 1116 - 1385
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 58 85.3% 3LCSA
DFGin None 5 7.4% 2YJRA
DFGin BLAminus 2 2.9% AF-Q9UM73-K1A
DFGout BBAminus 2 2.9% 5IUGA
DFGout None 1 1.5% 4FNYA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ALK AF-Q9UM73-K1A Q9UM73 1108 1393 1620.0 No_ligand No_ligand Active DFGin 5.946 14.3748 BLAminus -128.36, -171.81 51.94, 77.78 -92.22, 15.36 286.64, 85.92 -56.6, -33.49 in-in in 7.9769 Saltbr-in 2.6312 HRD-in -84.5, -39.96 65.84, -13.69 in-in-in SNCiii in-in ActLoopNT-in 2.9075 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.67, 132.62 APE9-dihe-in -132.53, 142.2 APE8-dihe-in -77.98, 67.6 APE8-rot-na 34.24 APE67-dihe-in -67.7, -9.18 -47.25, -44.33 APE12-dist-na 15.1897 APE11-dist-na 9.6169 APE10-dist-na 10.4614 APE9-dist-in 7.2037 None None None AF2 -1.0 1.0 1.0 A 286.0 286.0 0 30 30 0 [[1116, 1385]] 1.0 AF-Q9UM73-K1 TYR_ALK_HUMAN TYR 8.6e-91 309.7 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK AF-Q9UM73-K3A Q9UM73 1108 1393 1620.0 No_ligand No_ligand Active DFGin 6.0517 13.6075 BLAminus -131.74, -170.01 51.86, 66.91 -83.62, 16.51 291.43, 91.58 -58.46, -31.87 in-in in 8.0792 Saltbr-in 2.6868 HRD-in -85.25, -38.15 64.37, 4.14 in-in-in SNCiii in-in ActLoopNT-in 2.8669 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.58, 98.52 APE9-dihe-in -103.22, 145.61 APE8-dihe-in -72.6, 70.7 APE8-rot-na 33.25 APE67-dihe-in -77.31, -3.9 -52.0, -31.13 APE12-dist-na 16.4672 APE11-dist-na 10.4351 APE10-dist-na 11.2538 APE9-dist-in 7.2852 None None None AF2 -1.0 1.0 1.0 A 286.0 286.0 0 30 30 0 [[1116, 1385]] 1.0 AF-Q9UM73-K3 TYR_ALK_HUMAN TYR 8.6e-91 309.7 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 3LCTA Q9UM73 1093 1400 1620.0 ADP:1412 ATPlike Inactive DFGin 6.2665 15.1932 ABAminus -127.22, 10.26 -136.37, 129.73 -130.23, 18.7 291.41, 88.16 -49.74, -46.74 in-none in 8.1003 Saltbr-none 999.0 HRD-in -78.72, -45.58 81.21, -3.39 none-out-out SNCnoo out-out ActLoopNT-out 6.8864 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -94.62, -10.42 APE9-dihe-in -67.88, 140.77 APE8-dihe-in -81.63, 62.42 APE8-rot-na 34.08 APE67-dihe-in -66.16, -16.53 -61.79, -27.56 APE12-dist-na 14.7391 APE11-dist-na 15.1116 APE10-dist-na 9.9808 APE9-dist-out 8.0309 S1281G None None XRAY 2.1 0.207 0.255 A 344.0 308.0 0 30 30 0 [[1116, 1385]] 1.0 3lct TYR_ALK_HUMAN TYR 5e-90 307.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4TT7A Q9UM73 1095 1400 1620.0 COM:61501,COM:61502 Allosteric,Allosteric Inactive DFGin 6.3309 15.1043 ABAminus -129.34, 13.94 -143.37, 136.26 -133.45, 29.15 287.86, 86.47 -61.1, -46.06 in-in in 8.2758 Saltbr-in 2.8991 HRD-in -65.35, -47.66 76.28, -7.96 in-out-out SNCioo out-out ActLoopNT-out 6.7172 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -97.0, -10.73 APE9-dihe-in -72.98, 131.19 APE8-dihe-in -73.54, 64.64 APE8-rot-na 32.16 APE67-dihe-in -68.68, -12.97 -52.76, -40.18 APE12-dist-na 14.9463 APE11-dist-na 15.2582 APE10-dist-na 10.0877 APE9-dist-out 8.1337 None None None XRAY 2.1 0.195 0.244 A 325.0 290.0 16 30 28 2 [[1116, 1385]] 1.0 4tt7 TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 7JY4A Q9UM73 1096 1399 1620.0 W47:1701,W47:1702 Allosteric,Type1 Inactive DFGin 5.9202 14.5186 ABAminus -113.43, -9.3 -142.4, 138.16 -131.48, 29.53 294.61, 83.59 -63.18, -27.52 in-out in 7.579 Saltbr-out 4.2893 HRD-in -66.41, -52.1 72.58, 14.97 out-out-out SNCooo out-out ActLoopNT-out 6.6647 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.55, -8.29 APE9-dihe-in -68.93, 134.74 APE8-dihe-in -72.25, 67.62 APE8-rot-na 30.54 APE67-dihe-in -68.71, -7.15 -58.46, -37.5 APE12-dist-na 14.864 APE11-dist-na 15.6375 APE10-dist-na 10.484 APE9-dist-out 8.4718 None None None XRAY 2.42 0.221 0.255 A 322.0 290.0 14 30 23 7 [[1116, 1385]] 1.0 7jy4 TYR_ALK_HUMAN TYR 1.3e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 2YHVA Q9UM73 1093 1401 1620.0 No_ligand No_ligand Inactive DFGin 6.2916 15.188 ABAminus -123.67, -1.11 -136.06, 135.4 -132.07, 27.87 288.99, 87.09 -68.12, -28.8 in-out in 8.0074 Saltbr-out 4.973 HRD-in -77.85, -44.61 80.59, -11.15 out-out-out SNCooo out-out ActLoopNT-out 6.9708 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.52, -6.03 APE9-dihe-in -64.98, 136.8 APE8-dihe-in -78.21, 58.76 APE8-rot-na 28.31 APE67-dihe-in -70.14, -11.55 -58.4, -31.21 APE12-dist-na 14.5833 APE11-dist-na 15.0032 APE10-dist-na 10.0023 APE9-dist-out 8.1027 L1196M None None XRAY 1.9 0.206 0.238 A 342.0 292.0 17 30 24 6 [[1116, 1385]] 1.0 2yhv TYR_ALK_HUMAN TYR 6e-91 310.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4ANLA Q9UM73 1094 1402 1620.0 No_ligand No_ligand Inactive DFGin 6.3187 15.074 ABAminus -122.56, -44.06 -97.45, 124.8 -122.56, 30.81 292.45, 83.3 -66.54, -36.82 in-out in 8.0229 Saltbr-out 4.8522 HRD-in -74.81, -43.42 79.26, -10.5 out-out-out SNCooo out-out ActLoopNT-out 6.9758 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.21, -6.47 APE9-dihe-in -62.46, 134.19 APE8-dihe-in -75.42, 58.77 APE8-rot-na 29.27 APE67-dihe-in -71.73, -7.68 -54.8, -34.96 APE12-dist-na 14.3762 APE11-dist-na 14.7897 APE10-dist-na 9.8499 APE9-dist-out 8.0398 G1269A None None XRAY 1.7 0.202 0.216 A 342.0 293.0 16 30 24 6 [[1116, 1385]] 1.0 4anl TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4FNWA Q9UM73 1084 1405 1620.0 No_ligand No_ligand Inactive DFGin 6.2663 14.909 ABAminus -118.46, -25.35 -118.23, 130.17 -123.97, 30.37 289.23, 85.23 -66.19, -35.54 in-in in 7.9726 Saltbr-in 3.2706 HRD-in -71.6, -47.27 80.64, -6.43 in-out-out SNCioo out-out ActLoopNT-out 7.0091 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.87, -11.88 APE9-dihe-in -57.72, 142.89 APE8-dihe-in -82.66, 63.25 APE8-rot-na 32.43 APE67-dihe-in -71.06, -7.27 -50.06, -41.71 APE12-dist-na 11.9215 APE11-dist-na 15.1006 APE10-dist-na 10.0549 APE9-dist-in 7.9156 C1097S,F1174L None None XRAY 1.75 0.181 0.203 A 327.0 304.0 18 30 22 8 [[1116, 1385]] 1.0 4fnw TYR_ALK_HUMAN TYR 1.1e-90 309.4 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4FNXA Q9UM73 1093 1404 1620.0 No_ligand No_ligand Inactive DFGin 6.0557 14.8296 ABAminus -115.68, -17.57 -132.37, 141.55 -132.11, 50.23 294.37, 89.4 -81.69, -11.71 in-in in 7.8786 Saltbr-in 2.8996 HRD-in -67.87, -45.92 63.48, 21.39 in-out-out SNCioo out-out ActLoopNT-out 8.7961 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.41, -1.04 APE9-dihe-in -70.97, 126.88 APE8-dihe-in -77.01, 61.37 APE8-rot-na 28.92 APE67-dihe-in -68.85, -9.84 -51.53, -36.34 APE12-dist-na 12.798 APE11-dist-na 16.4257 APE10-dist-na 11.5513 APE9-dist-out 8.7707 C1097S,R1275Q None None XRAY 1.7 0.196 0.23 A 327.0 292.0 20 30 21 9 [[1116, 1385]] 1.0 4fnx TYR_ALK_HUMAN TYR 3.6e-90 307.7 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 6CDTA Q9UM73 1093 1400 1620.0 No_ligand No_ligand Inactive DFGin 6.3001 15.1244 ABAminus -123.35, -15.42 -125.06, 128.52 -124.36, 30.18 290.06, 83.02 -64.75, -38.93 in-out in 7.9953 Saltbr-out 4.9785 HRD-in -72.97, -44.41 80.06, -9.45 out-out-out SNCooo out-out ActLoopNT-out 7.0241 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -101.22, -7.31 APE9-dihe-in -65.06, 137.47 APE8-dihe-in -74.57, 60.9 APE8-rot-na 29.07 APE67-dihe-in -75.35, -6.12 -48.18, -42.21 APE12-dist-na 14.4527 APE11-dist-na 14.7792 APE10-dist-na 9.783 APE9-dist-in 7.8611 None None None XRAY 1.8 0.196 0.226 A 327.0 292.0 16 30 24 6 [[1116, 1385]] 1.0 6cdt TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 2YJSA Q9UM73 1094 1402 1620.0 No_ligand No_ligand Inactive DFGin 5.9329 15.0657 ABAminus -121.83, -11.53 -129.45, 132.48 -129.61, 30.1 290.02, 84.24 -67.53, -32.65 in-out in 8.5294 Saltbr-out 3.7588 HRD-in -74.02, -46.25 80.81, -7.98 out-out-out SNCooo out-out ActLoopNT-out 6.9634 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -95.71, -13.28 APE9-dihe-in -61.54, 135.1 APE8-dihe-in -77.63, 61.25 APE8-rot-na 30.06 APE67-dihe-in -69.46, -13.22 -55.44, -32.78 APE12-dist-na 14.1592 APE11-dist-na 15.2679 APE10-dist-na 10.2679 APE9-dist-out 8.1891 C1156Y None None XRAY 1.9 0.211 0.243 A 342.0 290.0 19 30 22 8 [[1116, 1385]] 1.0 2yjs TYR_ALK_HUMAN TYR 2.2e-90 308.4 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 3L9PA Q9UM73 1093 1400 1620.0 No_ligand No_ligand Inactive DFGin 6.2188 15.1559 ABAminus -126.0, -1.93 -131.15, 131.2 -131.41, 25.42 291.27, 88.64 -59.73, -44.21 in-none in 7.9825 Saltbr-none 999.0 HRD-in -69.61, -44.54 77.55, -8.47 none-out-out SNCnoo out-out ActLoopNT-out 6.8826 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.3, -11.47 APE9-dihe-in -69.19, 138.58 APE8-dihe-in -80.43, 62.6 APE8-rot-na 32.84 APE67-dihe-in -67.59, -13.49 -45.09, -43.43 APE12-dist-na 14.948 APE11-dist-na 15.1102 APE10-dist-na 10.0091 APE9-dist-in 7.9038 S1281G None None XRAY 1.8 0.192 0.226 A 367.0 303.0 5 30 30 0 [[1116, 1385]] 1.0 3l9p TYR_ALK_HUMAN TYR 6.2e-90 307.0 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4ANSA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 6.2485 15.1618 ABAminus -128.23, -41.44 -98.11, 120.9 -117.53, 30.59 287.81, 85.26 -66.49, -38.26 in-out in 8.265 Saltbr-out 4.8918 HRD-in -72.85, -44.3 78.64, -9.03 out-out-out SNCooo out-out ActLoopNT-out 6.908 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.15, -7.92 APE9-dihe-in -66.26, 134.84 APE8-dihe-in -77.14, 60.8 APE8-rot-na 30.33 APE67-dihe-in -70.27, -10.51 -58.92, -29.59 APE12-dist-na 14.6611 APE11-dist-na 14.8834 APE10-dist-na 9.857 APE9-dist-out 8.0387 L1196M,G1269A None None XRAY 1.85 0.201 0.231 A 342.0 294.0 16 30 24 6 [[1116, 1385]] 1.0 4ans TYR_ALK_HUMAN TYR 5.2e-91 310.5 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 2YFXA Q9UM73 1093 1401 1620.0 VGH:9000 Type1 Inactive DFGin 6.2206 14.8808 ABAminus -122.22, -28.6 -114.9, 132.72 -127.11, 33.52 293.03, 85.04 -65.89, -37.73 in-out in 7.9144 Saltbr-out 4.7498 HRD-in -73.95, -43.63 78.32, -9.23 out-out-out SNCooo out-out ActLoopNT-out 6.9557 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.12, -9.34 APE9-dihe-in -61.51, 137.47 APE8-dihe-in -77.72, 57.54 APE8-rot-na 29.78 APE67-dihe-in -70.24, -8.94 -56.4, -32.44 APE12-dist-na 14.505 APE11-dist-na 14.9332 APE10-dist-na 9.9197 APE9-dist-out 8.0505 L1196M None None XRAY 1.7 0.208 0.234 A 327.0 293.0 16 30 24 6 [[1116, 1385]] 1.0 2yfx TYR_ALK_HUMAN TYR 5.1e-91 310.5 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4CLJA Q9UM73 1094 1402 1620.0 5P8:2402 Type1 Inactive DFGin 6.2031 14.8054 ABAminus -125.62, -0.02 -140.07, 135.04 -130.43, 32.34 295.46, 85.14 -65.98, -39.5 in-in in 8.0111 Saltbr-in 2.7108 HRD-in -71.97, -45.96 80.49, -8.87 in-out-out SNCioo out-out ActLoopNT-out 6.9627 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.51, -5.34 APE9-dihe-in -68.88, 140.43 APE8-dihe-in -76.17, 58.33 APE8-rot-na 29.07 APE67-dihe-in -72.79, -6.46 -47.28, -42.69 APE12-dist-na 14.5577 APE11-dist-na 14.8066 APE10-dist-na 9.7887 APE9-dist-in 7.9372 L1196M None None XRAY 1.66 0.197 0.229 A 327.0 296.0 13 30 24 6 [[1116, 1385]] 1.0 4clj TYR_ALK_HUMAN TYR 5.1e-91 310.5 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4CD0A Q9UM73 1094 1402 1620.0 AWJ:1500 Type1 Inactive DFGin 6.2095 14.8068 ABAminus -124.48, -7.47 -131.66, 141.46 -133.85, 29.84 290.85, 86.66 -65.46, -35.12 in-in in 7.7112 Saltbr-in 2.7447 HRD-in -77.45, -47.18 84.39, -11.38 in-out-out SNCioo out-out ActLoopNT-out 6.8871 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.9, -13.71 APE9-dihe-in -68.46, 134.66 APE8-dihe-in -73.25, 65.7 APE8-rot-na 30.38 APE67-dihe-in -69.89, -9.61 -53.98, -40.39 APE12-dist-na 14.7046 APE11-dist-na 14.9102 APE10-dist-na 9.7245 APE9-dist-in 7.9756 L1196M None None XRAY 2.23 0.198 0.25 A 342.0 296.0 13 30 24 6 [[1116, 1385]] 1.0 4cd0 TYR_ALK_HUMAN TYR 6e-91 310.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4ANQA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 6.2087 14.9738 ABAminus -128.3, -36.39 -101.79, 127.42 -123.56, 31.99 288.31, 85.14 -69.12, -35.87 in-out in 8.2697 Saltbr-out 4.7889 HRD-in -73.02, -46.15 80.91, -7.4 out-out-out SNCooo out-out ActLoopNT-out 6.947 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -98.41, -8.07 APE9-dihe-in -67.75, 134.94 APE8-dihe-in -74.89, 59.28 APE8-rot-na 29.64 APE67-dihe-in -70.46, -10.96 -58.56, -29.68 APE12-dist-na 14.7237 APE11-dist-na 14.9551 APE10-dist-na 9.9221 APE9-dist-out 8.0186 G1269A None None XRAY 1.76 0.201 0.217 A 342.0 294.0 16 30 24 6 [[1116, 1385]] 1.0 4anq TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 5AA9A Q9UM73 1093 1402 1620.0 5P8:2402 Type1 Inactive DFGin 6.1824 14.8906 ABAminus -123.86, -6.83 -134.63, 136.55 -132.06, 29.87 289.56, 85.44 -66.04, -35.64 in-out in 8.1567 Saltbr-out 4.5375 HRD-in -75.17, -44.12 79.72, -10.27 out-out-out SNCooo out-out ActLoopNT-out 6.8482 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.37, -11.88 APE9-dihe-in -67.63, 135.25 APE8-dihe-in -76.86, 63.04 APE8-rot-na 30.41 APE67-dihe-in -70.03, -11.65 -60.61, -27.66 APE12-dist-na 14.9157 APE11-dist-na 15.2297 APE10-dist-na 10.0961 APE9-dist-out 8.1585 L1198F None None XRAY 1.93 0.201 0.237 A 327.0 296.0 14 30 24 6 [[1116, 1385]] 1.0 5aa9 TYR_ALK_HUMAN TYR 4.4e-91 310.7 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 5AAAA Q9UM73 1093 1401 1620.0 VGH:9000 Type1 Inactive DFGin 6.2088 14.916 ABAminus -119.08, -27.29 -116.14, 136.82 -130.64, 32.52 289.46, 85.69 -67.72, -37.15 in-out in 7.9686 Saltbr-out 4.6697 HRD-in -74.4, -45.03 79.43, -9.27 out-out-out SNCooo out-out ActLoopNT-out 6.8981 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.98, -3.96 APE9-dihe-in -73.12, 136.6 APE8-dihe-in -77.4, 61.62 APE8-rot-na 28.9 APE67-dihe-in -71.26, -10.51 -60.21, -28.6 APE12-dist-na 14.5554 APE11-dist-na 14.8493 APE10-dist-na 9.8001 APE9-dist-out 8.0299 L1198F None None XRAY 1.73 0.201 0.206 A 327.0 295.0 14 30 24 6 [[1116, 1385]] 1.0 5aaa TYR_ALK_HUMAN TYR 4.4e-91 310.7 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 5AA8A Q9UM73 1093 1402 1620.0 5P8:2402 Type1 Inactive DFGin 6.0863 14.918 ABAminus -121.09, -8.69 -130.71, 131.76 -128.08, 33.6 288.19, 85.62 -75.96, -22.55 in-out in 8.2447 Saltbr-out 4.485 HRD-in -76.73, -45.37 80.25, -8.63 out-out-out SNCooo out-out ActLoopNT-out 6.7988 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.53, -15.21 APE9-dihe-in -61.78, 135.61 APE8-dihe-in -77.32, 62.22 APE8-rot-na 29.6 APE67-dihe-in -71.9, -11.44 -60.22, -27.26 APE12-dist-na 14.6816 APE11-dist-na 15.5516 APE10-dist-na 10.4812 APE9-dist-out 8.1876 C1156Y,L1198F None None XRAY 1.86 0.209 0.233 A 327.0 293.0 17 30 24 6 [[1116, 1385]] 1.0 5aa8 TYR_ALK_HUMAN TYR 5.9e-91 310.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 5AABA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 5.962 14.9414 ABAminus -122.06, -28.4 -115.22, 132.25 -127.31, 26.85 289.37, 81.1 -65.12, -33.9 in-out in 8.0829 Saltbr-out 4.2699 HRD-in -73.35, -48.11 83.65, -8.17 out-out-out SNCooo out-out ActLoopNT-out 6.9633 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.88, -2.64 APE9-dihe-in -78.59, 133.38 APE8-dihe-in -74.05, 62.22 APE8-rot-na 30.08 APE67-dihe-in -71.71, -12.93 -64.03, -23.79 APE12-dist-na 15.1004 APE11-dist-na 15.2049 APE10-dist-na 10.0874 APE9-dist-out 8.0863 C1156Y,L1198F None None XRAY 2.2 0.211 0.246 A 327.0 294.0 16 30 24 6 [[1116, 1385]] 1.0 5aab TYR_ALK_HUMAN TYR 5.9e-91 310.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 6MX8A Q9UM73 1094 1400 1620.0 6GY:1500 Type1 Inactive DFGin 6.1418 14.6623 ABAminus -114.12, -38.77 -118.14, 138.18 -129.19, 26.62 289.5, 87.05 -61.73, -41.9 in-in in 7.7858 Saltbr-in 3.2344 HRD-in -72.93, -50.14 84.31, -4.9 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.89, -3.2 APE9-dihe-in -73.94, 138.53 APE8-dihe-in -85.7, 68.86 APE8-rot-na 37.09 APE67-dihe-in -74.13, -8.15 -48.67, -39.52 APE12-dist-na 14.2439 APE11-dist-na 15.1838 APE10-dist-na 10.0835 APE9-dist-out 8.1676 None None None XRAY 1.96 0.185 0.227 A 307.0 282.0 25 30 17 13 [[1116, 1385]] 1.0 6mx8 TYR_ALK_HUMAN TYR 1.1e-90 309.4 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 2XB7A Q9UM73 1095 1401 1620.0 GUI:1501 Type1 Inactive DFGin 5.7305 14.5992 ABAminus -132.42, -0.18 -141.44, 142.16 -131.03, 43.77 292.96, 89.17 -72.28, -38.54 in-in in 7.5319 Saltbr-in 3.1842 HRD-in -87.04, -46.67 85.76, -13.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.32, -3.08 APE9-dihe-in -73.74, 136.06 APE8-dihe-in -78.24, 56.9 APE8-rot-na 30.55 APE67-dihe-in -70.57, -6.09 -40.69, -40.8 APE12-dist-na 999.0 APE11-dist-na 15.2726 APE10-dist-na 10.496 APE9-dist-out 8.3356 None None None XRAY 2.5 0.195 0.243 A 315.0 286.0 21 30 16 14 [[1116, 1385]] 1.0 2xb7 TYR_ALK_HUMAN TYR 1.2e-90 309.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 2XBAA Q9UM73 1095 1402 1620.0 571:1501 Type1 Inactive DFGin 6.0851 14.8742 ABAminus -122.73, -16.28 -123.08, 138.16 -132.25, 31.45 293.73, 90.75 -70.57, -36.09 in-in in 7.9954 Saltbr-in 2.825 HRD-in -75.43, -45.29 77.63, -4.66 in-out-out SNCioo out-out ActLoopNT-out 6.9938 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.39, 0.87 APE9-dihe-in -70.63, 140.95 APE8-dihe-in -81.29, 62.03 APE8-rot-na 33.35 APE67-dihe-in -68.85, -9.81 -51.55, -41.48 APE12-dist-na 999.0 APE11-dist-na 14.8997 APE10-dist-na 9.9146 APE9-dist-out 8.1052 None None None XRAY 1.95 0.195 0.229 A 315.0 284.0 24 30 20 10 [[1116, 1385]] 1.0 2xba TYR_ALK_HUMAN TYR 1.2e-90 309.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 5FTOA Q9UM73 1094 1401 1620.0 YMX:62402 Type1 Inactive DFGin 6.6137 15.1027 ABAminus -123.37, 0.05 -137.72, 139.58 -135.41, 24.82 289.1, 90.09 -60.28, -46.38 in-in in 7.802 Saltbr-in 2.7128 HRD-in -72.55, -46.15 82.21, -13.13 in-out-out SNCioo out-out ActLoopNT-out 7.0886 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -91.32, -8.05 APE9-dihe-in -57.49, 136.7 APE8-dihe-in -78.81, 60.16 APE8-rot-na 28.18 APE67-dihe-in -67.52, -8.47 -48.73, -45.52 APE12-dist-na 11.5172 APE11-dist-na 14.8572 APE10-dist-na 9.821 APE9-dist-in 7.9666 None None None XRAY 2.22 0.199 0.257 A 315.0 297.0 11 30 23 7 [[1116, 1385]] 1.0 5fto TYR_ALK_HUMAN TYR 1.2e-90 309.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 5FTQA Q9UM73 1094 1401 1620.0 U4W:62402 Type1 Inactive DFGin 6.5385 14.8246 ABAminus -118.64, -8.41 -138.53, 135.08 -126.73, 26.7 295.74, 85.6 -58.63, -49.74 in-in in 7.6052 Saltbr-in 2.5791 HRD-in -70.78, -46.77 80.03, 2.04 in-out-out SNCioo out-out ActLoopNT-out 6.9291 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.78, -4.85 APE9-dihe-in -67.75, 140.01 APE8-dihe-in -77.42, 62.81 APE8-rot-na 24.56 APE67-dihe-in -73.5, -8.73 -54.41, -36.36 APE12-dist-na 12.6879 APE11-dist-na 14.9562 APE10-dist-na 9.9213 APE9-dist-in 7.795 None None None XRAY 1.7 0.175 0.22 A 315.0 292.0 16 30 22 8 [[1116, 1385]] 1.0 5ftq TYR_ALK_HUMAN TYR 1.2e-90 309.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 8ARJA Q9UM73 1103 1399 1620.0 NRR:1501 Type1 Inactive DFGin 6.1187 14.5245 ABAminus -117.07, -37.76 -110.06, 107.52 -111.08, 38.44 282.92, 90.71 -87.79, -43.75 in-in in 7.8615 Saltbr-in 2.577 HRD-in -71.95, -46.72 76.96, -5.2 in-out-out SNCioo out-out ActLoopNT-out 6.5525 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -98.2, -2.7 APE9-dihe-in -71.32, 134.53 APE8-dihe-in -74.4, 64.1 APE8-rot-na 36.74 APE67-dihe-in -65.93, -15.67 -63.14, -27.35 APE12-dist-na 15.6023 APE11-dist-na 15.7953 APE10-dist-na 10.5703 APE9-dist-out 8.4005 None None None XRAY 1.645 0.198 0.229 A 321.0 275.0 22 30 22 8 [[1116, 1385]] 1.0 8arj TYR_ALK_HUMAN TYR 1.3e-90 309.2 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 6E0RA Q9UM73 1099 1399 1620.0 HKJ:1500 Type1 Inactive DFGin 5.9898 14.1302 ABAminus -126.54, 6.88 -146.63, 139.75 -129.52, 23.79 286.55, 86.22 -54.44, -45.81 in-out in 8.2911 Saltbr-out 4.4908 HRD-in -74.7, -43.96 75.16, -3.83 out-out-none SNCoon out-none ActLoopNT-out 6.4909 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -139.14 APE9-dihe-in -62.89, 135.23 APE8-dihe-in -79.57, 61.66 APE8-rot-na 34.01 APE67-dihe-in -70.37, -9.48 -43.47, -41.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.8829 APE9-dist-in 7.8082 None None None XRAY 2.303 0.241 0.296 A 322.0 279.0 22 30 19 11 [[1116, 1385]] 1.0 6e0r TYR_ALK_HUMAN TYR 1.3e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 6EBWA Q9UM73 1096 1399 1620.0 J3Y:1500 Type1 Inactive DFGin 6.3319 14.7708 ABAminus -124.53, 13.61 -158.52, 147.01 -134.91, 49.92 284.01, 90.06 -74.0, -48.2 in-out in 7.7246 Saltbr-out 5.1352 HRD-in -83.27, -44.43 72.92, 3.22 out-out-none SNCoon out-none ActLoopNT-out 7.088 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 149.36 APE8-dihe-in -68.97, 75.32 APE8-rot-na 28.29 APE67-dihe-in -64.76, -14.09 -59.15, -42.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.811 None None None XRAY 2.455 0.246 0.286 A 322.0 277.0 24 30 16 14 [[1116, 1385]] 1.0 6ebw TYR_ALK_HUMAN TYR 1.3e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 7JYRA Q9UM73 1095 1399 1620.0 VTA:1601 Type1 Inactive DFGin 6.0368 14.6472 ABAminus -117.25, -3.0 -143.43, 138.22 -132.95, 32.31 290.25, 83.3 -65.6, -36.91 in-out in 7.9182 Saltbr-out 4.7574 HRD-in -74.08, -42.05 82.36, -13.99 out-out-out SNCooo out-out ActLoopNT-out 6.9088 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.47, -3.99 APE9-dihe-in -74.12, 138.94 APE8-dihe-in -75.24, 67.71 APE8-rot-na 31.71 APE67-dihe-in -73.48, -9.59 -58.72, -34.79 APE12-dist-na 15.1778 APE11-dist-na 15.6549 APE10-dist-na 10.5004 APE9-dist-out 8.4538 None None None XRAY 2.32 0.216 0.247 A 322.0 287.0 18 30 23 7 [[1116, 1385]] 1.0 7jyr TYR_ALK_HUMAN TYR 1.3e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 7JYSA Q9UM73 1095 1399 1620.0 VTD:1601 Type1 Inactive DFGin 5.8473 14.4212 ABAminus -117.17, -14.0 -132.7, 135.12 -128.93, 36.18 292.83, 86.2 -69.53, -37.99 in-in in 7.9616 Saltbr-in 2.5387 HRD-in -70.79, -47.81 83.57, -7.04 in-out-out SNCioo out-out ActLoopNT-out 6.9537 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -114.43, -7.14 APE9-dihe-in -64.31, 136.8 APE8-dihe-in -71.91, 66.98 APE8-rot-na 26.54 APE67-dihe-in -68.83, -10.73 -59.12, -37.36 APE12-dist-na 15.097 APE11-dist-na 15.4959 APE10-dist-na 10.3537 APE9-dist-out 8.1897 None None None XRAY 2.22 0.216 0.253 A 322.0 281.0 24 30 23 7 [[1116, 1385]] 1.0 7jys TYR_ALK_HUMAN TYR 1.3e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 7JYTA Q9UM73 1095 1399 1620.0 VRM:1502 Type1 Inactive DFGin 5.9774 14.4605 ABAminus -124.69, -2.73 -143.22, 137.8 -131.88, 32.76 291.21, 85.91 -67.73, -37.01 in-out in 7.9242 Saltbr-out 5.3271 HRD-in -79.43, -44.52 77.34, -3.4 out-out-out SNCooo out-out ActLoopNT-out 6.8231 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -112.03, -10.17 APE9-dihe-in -61.0, 135.32 APE8-dihe-in -73.73, 64.74 APE8-rot-na 29.73 APE67-dihe-in -69.91, -11.24 -57.53, -36.41 APE12-dist-na 15.0412 APE11-dist-na 15.5277 APE10-dist-na 10.358 APE9-dist-out 8.1429 None None None XRAY 2.0 0.209 0.224 A 322.0 281.0 24 30 23 7 [[1116, 1385]] 1.0 7jyt TYR_ALK_HUMAN TYR 1.3e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 2XP2A Q9UM73 1093 1401 1620.0 VGH:9000 Type1 Inactive DFGin 6.01 14.8527 ABAminus -116.89, -30.31 -113.6, 135.35 -129.42, 33.32 290.86, 85.52 -68.93, -36.66 in-out in 8.312 Saltbr-out 4.8435 HRD-in -70.6, -46.14 82.26, -7.39 out-out-out SNCooo out-out ActLoopNT-out 6.7853 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -14.78 APE9-dihe-in -71.8, 131.97 APE8-dihe-in -75.49, 62.54 APE8-rot-na 30.87 APE67-dihe-in -72.66, -13.49 -62.38, -23.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.1483 APE9-dist-out 8.2573 None None None XRAY 1.9 0.207 0.252 A 327.0 289.0 20 30 21 9 [[1116, 1385]] 1.0 2xp2 TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4CCBA Q9UM73 1093 1401 1620.0 OFG:2401 Type1 Inactive DFGin 6.0497 14.7677 ABAminus -119.22, -9.24 -133.44, 139.2 -130.65, 36.27 292.81, 84.36 -70.77, -32.92 in-in in 7.8494 Saltbr-in 2.9192 HRD-in -75.15, -47.62 82.69, -9.54 in-out-none SNCion out-none ActLoopNT-out 6.8955 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -19.77 APE9-dihe-in -65.32, 136.43 APE8-dihe-in -75.25, 61.07 APE8-rot-na 30.01 APE67-dihe-in -69.24, -12.29 -57.16, -31.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.9496 APE9-dist-in 7.9084 None None None XRAY 2.03 0.202 0.235 A 327.0 291.0 18 30 21 9 [[1116, 1385]] 1.0 4ccb TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4CCUA Q9UM73 1093 1402 1620.0 AWF:1500 Type1 Inactive DFGin 6.0199 14.6231 ABAminus -118.73, -9.8 -132.17, 139.04 -133.56, 37.48 295.42, 86.35 -74.53, -27.89 in-out in 8.2766 Saltbr-out 4.6887 HRD-in -77.94, -47.73 82.62, -10.67 out-out-out SNCooo out-out ActLoopNT-out 6.8034 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.98, -27.23 APE9-dihe-in -56.62, 135.11 APE8-dihe-in -75.38, 65.75 APE8-rot-na 29.29 APE67-dihe-in -70.29, -14.23 -60.1, -29.45 APE12-dist-na 14.5251 APE11-dist-na 15.1704 APE10-dist-na 10.0283 APE9-dist-in 7.7958 None None None XRAY 2.0 0.202 0.233 A 327.0 293.0 17 30 24 6 [[1116, 1385]] 1.0 4ccu TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4CLIA Q9UM73 1093 1401 1620.0 5P8:2401 Type1 Inactive DFGin 6.1037 14.6636 ABAminus -126.26, -5.06 -135.36, 136.5 -131.98, 39.01 293.42, 86.05 -79.91, -26.98 in-out in 8.3036 Saltbr-out 4.5186 HRD-in -75.26, -46.3 81.47, -9.07 out-out-out SNCooo out-out ActLoopNT-out 6.8442 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.34, -12.93 APE9-dihe-in -62.11, 137.41 APE8-dihe-in -77.3, 59.87 APE8-rot-na 29.14 APE67-dihe-in -74.79, -11.71 -58.14, -27.0 APE12-dist-na 14.6641 APE11-dist-na 14.9821 APE10-dist-na 10.0029 APE9-dist-in 7.8293 None None None XRAY 2.05 0.199 0.245 A 327.0 295.0 14 30 24 6 [[1116, 1385]] 1.0 4cli TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4CMOA Q9UM73 1093 1402 1620.0 YPW:2402 Type1 Inactive DFGin 6.1786 14.7285 ABAminus -120.95, -9.17 -132.13, 138.79 -131.64, 32.19 292.59, 86.4 -67.48, -36.83 in-out in 8.1084 Saltbr-out 5.0989 HRD-in -74.69, -45.72 80.53, -9.82 out-out-out SNCooo out-out ActLoopNT-out 6.894 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.18, -16.6 APE9-dihe-in -61.82, 137.9 APE8-dihe-in -75.79, 58.08 APE8-rot-na 29.65 APE67-dihe-in -70.92, -9.19 -55.73, -32.13 APE12-dist-na 14.61 APE11-dist-na 14.9019 APE10-dist-na 9.8208 APE9-dist-in 7.8311 None None None XRAY 2.05 0.199 0.245 A 327.0 296.0 14 30 24 6 [[1116, 1385]] 1.0 4cmo TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4CMTA Q9UM73 1093 1401 1620.0 GWH:2401 Type1 Inactive DFGin 6.2115 14.8303 ABAminus -123.22, -5.39 -133.47, 138.97 -132.82, 32.21 291.71, 85.66 -66.83, -37.56 in-in in 7.927 Saltbr-in 2.6223 HRD-in -73.35, -43.01 78.17, -7.26 in-out-none SNCion out-none ActLoopNT-out 6.9135 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 3.2 APE9-dihe-in -71.77, 138.91 APE8-dihe-in -76.34, 59.3 APE8-rot-na 30.92 APE67-dihe-in -69.85, -8.04 -57.32, -34.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.7928 APE9-dist-in 7.8761 None None None XRAY 1.73 0.214 0.248 A 327.0 288.0 21 30 21 9 [[1116, 1385]] 1.0 4cmt TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4CMUA Q9UM73 1093 1401 1620.0 IV7:2401 Type1 Inactive DFGin 6.2247 14.8479 ABAminus -119.02, -15.67 -129.52, 137.46 -129.87, 35.57 292.32, 83.85 -72.08, -34.25 in-out in 8.2683 Saltbr-out 5.0523 HRD-in -73.08, -46.65 81.42, -8.55 out-out-out SNCooo out-out ActLoopNT-out 6.9437 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -98.74, -12.22 APE9-dihe-in -65.64, 137.39 APE8-dihe-in -75.72, 59.54 APE8-rot-na 29.91 APE67-dihe-in -71.19, -9.41 -57.38, -31.15 APE12-dist-na 14.6694 APE11-dist-na 14.8711 APE10-dist-na 9.8653 APE9-dist-in 7.8939 None None None XRAY 1.8 0.206 0.227 A 327.0 295.0 14 30 24 6 [[1116, 1385]] 1.0 4cmu TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4CNHA Q9UM73 1094 1402 1620.0 3U9:2402 Type1 Inactive DFGin 6.3283 15.0458 ABAminus -121.41, -13.5 -134.76, 134.27 -127.13, 24.83 291.86, 80.94 -58.37, -37.06 in-out in 7.9054 Saltbr-out 4.9159 HRD-in -72.36, -47.54 81.36, -5.81 out-out-none SNCoon out-none ActLoopNT-out 7.0247 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 36.87 APE9-dihe-in -64.44, 124.84 APE8-dihe-in -71.68, 78.76 APE8-rot-na 25.36 APE67-dihe-in -71.29, -8.43 -50.25, -44.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.445 APE9-dist-in 6.8106 None None None XRAY 1.9 0.206 0.25 A 327.0 286.0 23 30 20 10 [[1116, 1385]] 1.0 4cnh TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4CTBA Q9UM73 1093 1402 1620.0 KVC:2402 Type1 Inactive DFGin 6.2156 14.8492 ABAminus -119.67, -9.24 -135.77, 135.53 -130.14, 34.99 293.83, 84.83 -68.92, -36.75 in-in in 7.8013 Saltbr-in 3.0825 HRD-in -73.33, -46.07 82.91, -9.21 in-out-out SNCioo out-out ActLoopNT-out 6.9413 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.19, -13.84 APE9-dihe-in -65.2, 138.92 APE8-dihe-in -74.78, 60.38 APE8-rot-na 30.11 APE67-dihe-in -72.32, -8.28 -56.62, -34.41 APE12-dist-na 14.636 APE11-dist-na 14.9968 APE10-dist-na 9.9651 APE9-dist-out 8.0006 None None None XRAY 1.79 0.21 0.247 A 327.0 293.0 17 30 24 6 [[1116, 1385]] 1.0 4ctb TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4CTCA Q9UM73 1094 1402 1620.0 J99:2402 Type1 Inactive DFGin 6.0868 14.4364 ABAminus -113.76, -13.97 -127.87, 134.88 -130.21, 34.39 296.92, 88.54 -69.58, -32.9 in-out in 7.818 Saltbr-out 4.6632 HRD-in -68.52, -47.86 79.55, -14.18 out-out-out SNCooo out-out ActLoopNT-out 6.6285 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.25, -22.21 APE9-dihe-in -63.2, 137.35 APE8-dihe-in -83.4, 68.98 APE8-rot-na 27.6 APE67-dihe-in -69.91, -15.73 -58.12, -29.13 APE12-dist-na 14.9347 APE11-dist-na 15.2582 APE10-dist-na 10.2032 APE9-dist-in 7.8235 None None None XRAY 2.03 0.194 0.216 A 327.0 289.0 20 30 22 8 [[1116, 1385]] 1.0 4ctc TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 5KZ0A Q9UM73 1093 1401 1620.0 6YL:1501 Type1 Inactive DFGin 5.9216 14.406 ABAminus -133.15, -11.67 -127.06, 138.04 -132.87, 29.16 292.21, 94.94 -79.99, -2.4 in-out in 7.9192 Saltbr-out 4.0839 HRD-in -74.2, -39.11 78.61, -15.85 out-out-out SNCooo out-out ActLoopNT-out 6.8345 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -92.46, -46.15 APE9-dihe-in -45.76, 137.83 APE8-dihe-in -84.92, 73.38 APE8-rot-na 33.7 APE67-dihe-in -73.49, -11.11 -70.16, -20.71 APE12-dist-na 15.231 APE11-dist-na 15.1964 APE10-dist-na 10.0438 APE9-dist-in 7.7877 None None None XRAY 2.3 0.18 0.269 A 327.0 293.0 16 30 22 8 [[1116, 1385]] 1.0 5kz0 TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 7R7KA Q9UM73 1094 1400 1620.0 25J:1501 Type1 Inactive DFGin 6.2963 14.7986 ABAminus -117.03, -7.91 -132.86, 139.73 -133.05, 30.6 293.43, 91.77 -61.89, -44.97 in-out in 7.758 Saltbr-out 4.764 HRD-in -63.52, -48.31 78.95, -7.31 out-out-out SNCooo out-out ActLoopNT-out 6.9056 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.56, -4.43 APE9-dihe-in -73.03, 141.44 APE8-dihe-in -80.52, 63.08 APE8-rot-na 29.68 APE67-dihe-in -66.55, -12.77 -43.97, -45.25 APE12-dist-na 14.1426 APE11-dist-na 14.9269 APE10-dist-na 9.8073 APE9-dist-in 7.9115 None None None XRAY 1.831 0.195 0.221 A 327.0 290.0 17 30 24 6 [[1116, 1385]] 1.0 7r7k TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 7R7RA Q9UM73 1093 1401 1620.0 AWJ:1501 Type1 Inactive DFGin 6.1215 14.6939 ABAminus -114.04, -10.1 -130.71, 138.84 -131.21, 32.52 294.04, 89.2 -62.61, -42.67 in-out in 8.0251 Saltbr-out 4.7495 HRD-in -66.43, -50.15 80.96, -9.24 out-out-out SNCooo out-out ActLoopNT-out 6.8833 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -105.96, -19.38 APE9-dihe-in -67.0, 138.74 APE8-dihe-in -79.51, 69.3 APE8-rot-na 29.25 APE67-dihe-in -68.73, -13.21 -57.11, -32.66 APE12-dist-na 14.4527 APE11-dist-na 14.9728 APE10-dist-na 9.8498 APE9-dist-in 7.7278 None None None XRAY 1.935 0.193 0.227 A 327.0 291.0 18 30 23 7 [[1116, 1385]] 1.0 7r7r TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4FNZA Q9UM73 1093 1402 1620.0 NZF:1501 Type1 Inactive DFGin 5.291 12.7997 ABAminus -135.46, 12.02 -152.76, 153.63 -83.97, -38.55 283.31, 122.35 73.66, 999.0 in-in in 8.5004 Saltbr-in 2.8123 HRD-in -72.66, -49.3 78.9, -9.45 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.65, -24.93 APE9-dihe-in -50.61, 132.71 APE8-dihe-in -79.34, 69.48 APE8-rot-na 27.73 APE67-dihe-in -74.42, -13.21 -56.44, -36.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8304 C1097S None None XRAY 2.6 0.202 0.261 A 327.0 287.0 23 30 15 15 [[1116, 1385]] 1.0 4fnz TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 5IUIA Q9UM73 1089 1400 1620.0 45Q:1501 Type1 Inactive DFGin 6.097 15.0666 ABAminus -115.96, -40.57 -98.03, 131.36 -128.94, 30.02 290.16, 88.83 -67.06, -40.42 in-in in 8.1728 Saltbr-in 2.9353 HRD-in -74.44, -37.49 70.23, -3.09 in-out-out SNCioo out-out ActLoopNT-out 7.0487 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -106.21, -6.36 APE9-dihe-in -64.31, 145.1 APE8-dihe-in -79.79, 58.82 APE8-rot-na 31.57 APE67-dihe-in -70.65, -5.92 -44.41, -46.15 APE12-dist-na 14.4423 APE11-dist-na 15.0558 APE10-dist-na 10.0388 APE9-dist-out 8.1167 C1097S None None XRAY 1.88 0.181 0.205 A 327.0 303.0 9 30 25 5 [[1116, 1385]] 1.0 5iui TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4FODA Q9UM73 1085 1405 1620.0 0UV:1501 Type1 Inactive DFGin 6.303 14.9416 ABAminus -126.17, 8.88 -148.68, 139.13 -133.76, 30.42 294.7, 92.17 -67.04, -41.19 in-in in 7.4866 Saltbr-in 2.605 HRD-in -73.82, -48.62 76.13, -0.28 in-out-out SNCioo out-out ActLoopNT-out 7.025 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -105.69, -7.83 APE9-dihe-in -60.03, 145.3 APE8-dihe-in -82.29, 62.32 APE8-rot-na 33.22 APE67-dihe-in -70.05, -10.83 -47.36, -42.53 APE12-dist-na 11.937 APE11-dist-na 15.0687 APE10-dist-na 10.0107 APE9-dist-in 7.8425 C1097S None None XRAY 2.0 0.18 0.221 A 333.0 308.0 13 30 23 7 [[1116, 1385]] 1.0 4fod TYR_ALK_HUMAN TYR 1.5e-90 309.0 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 3AOXA Q9UM73 1086 1401 1620.0 EMH:901 Type1 Inactive DFGin 6.4074 14.9437 ABAminus -137.07, 23.28 -158.41, 139.16 -133.43, 27.21 291.39, 95.08 -65.65, -43.18 in-in in 7.6565 Saltbr-in 2.5942 HRD-in -71.98, -46.85 79.15, -6.33 in-out-out SNCioo out-out ActLoopNT-out 6.9548 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -95.63, -6.24 APE9-dihe-in -65.1, 144.04 APE8-dihe-in -84.44, 65.15 APE8-rot-na 34.19 APE67-dihe-in -68.33, -10.93 -51.94, -40.89 APE12-dist-na 11.753 APE11-dist-na 14.9616 APE10-dist-na 9.9208 APE9-dist-in 7.9922 None None None XRAY 1.75 0.17 0.206 A 344.0 298.0 18 30 23 7 [[1116, 1385]] 1.0 3aox TYR_ALK_HUMAN TYR 1.7e-90 308.8 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 5A9UA Q9UM73 1093 1402 1620.0 5P8:2402 Type1 Inactive DFGin 6.068 14.6566 ABAminus -124.48, -3.05 -136.25, 135.66 -131.11, 34.63 291.44, 81.89 -72.61, -25.01 in-out in 8.1331 Saltbr-out 3.8384 HRD-in -74.43, -46.73 80.61, -9.35 out-out-out SNCooo out-out ActLoopNT-out 6.8438 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.6, -12.67 APE9-dihe-in -61.75, 137.74 APE8-dihe-in -78.53, 58.82 APE8-rot-na 30.41 APE67-dihe-in -71.12, -10.64 -57.9, -28.42 APE12-dist-na 14.791 APE11-dist-na 15.3736 APE10-dist-na 10.2941 APE9-dist-out 8.143 C1156Y None None XRAY 1.6 0.216 0.258 A 327.0 293.0 17 30 24 6 [[1116, 1385]] 1.0 5a9u TYR_ALK_HUMAN TYR 1.9e-90 308.6 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 5AACA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 6.0491 14.9478 ABAminus -115.19, -31.77 -111.83, 134.22 -128.43, 30.25 290.07, 81.16 -65.53, -32.88 in-out in 8.2704 Saltbr-out 4.6082 HRD-in -73.86, -46.4 82.42, -9.17 out-out-out SNCooo out-out ActLoopNT-out 6.9248 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.47, -8.93 APE9-dihe-in -64.75, 135.46 APE8-dihe-in -76.69, 59.35 APE8-rot-na 30.37 APE67-dihe-in -71.48, -11.11 -59.44, -28.8 APE12-dist-na 14.7445 APE11-dist-na 15.3235 APE10-dist-na 10.293 APE9-dist-out 8.1919 C1156Y None None XRAY 1.7 0.208 0.232 A 327.0 293.0 17 30 24 6 [[1116, 1385]] 1.0 5aac TYR_ALK_HUMAN TYR 1.9e-90 308.6 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 7BTTA Q9UM73 1093 1401 1620.0 F8R:1501 Type1 Inactive DFGin 6.1564 14.7855 ABAminus -122.03, -17.95 -119.49, 138.11 -134.22, 32.1 293.32, 88.16 -75.16, -36.17 in-in in 7.5925 Saltbr-in 2.8567 HRD-in -69.97, -43.61 74.45, -5.72 in-out-out SNCioo out-out ActLoopNT-out 7.0265 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.06, -5.75 APE9-dihe-in -67.85, 139.87 APE8-dihe-in -78.72, 64.66 APE8-rot-na 32.81 APE67-dihe-in -71.63, -7.08 -50.37, -43.62 APE12-dist-na 14.5626 APE11-dist-na 14.9078 APE10-dist-na 9.8213 APE9-dist-out 8.0875 None None None XRAY 1.86 0.188 0.209 A 320.0 304.0 5 30 30 0 [[1116, 1385]] 1.0 7btt TYR_ALK_HUMAN TYR 3.9e-90 307.6 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4FOBA Q9UM73 1093 1402 1620.0 0US:1501 Type1 Inactive DFGin 6.2031 14.6081 ABAminus -121.93, -5.87 -135.31, 135.62 -128.54, 34.16 296.11, 87.18 -69.77, -38.85 in-in in 7.8612 Saltbr-in 2.6092 HRD-in -75.01, -47.81 80.74, -11.97 in-out-out SNCioo out-out ActLoopNT-out 6.9633 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -99.67, -8.45 APE9-dihe-in -60.62, 141.15 APE8-dihe-in -80.22, 63.12 APE8-rot-na 30.66 APE67-dihe-in -69.42, -9.11 -51.4, -43.54 APE12-dist-na 14.3459 APE11-dist-na 14.7246 APE10-dist-na 9.6458 APE9-dist-in 7.854 C1097S None None XRAY 1.9 0.203 0.255 A 353.0 295.0 15 30 24 6 [[1116, 1385]] 1.0 4fob TYR_ALK_HUMAN TYR 1.8e-90 308.8 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4FOCA Q9UM73 1093 1402 1620.0 0UU:1501 Type1 Inactive DFGin 6.3245 14.5687 ABAminus -123.54, -7.23 -132.63, 134.75 -129.46, 36.57 293.68, 84.81 -70.2, -37.62 in-in in 7.7863 Saltbr-in 3.1014 HRD-in -69.96, -48.47 78.5, -3.5 in-out-out SNCioo out-out ActLoopNT-out 6.9878 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.01, -12.7 APE9-dihe-in -61.61, 144.79 APE8-dihe-in -84.7, 68.48 APE8-rot-na 34.22 APE67-dihe-in -73.32, -8.77 -52.28, -39.37 APE12-dist-na 12.056 APE11-dist-na 15.0289 APE10-dist-na 9.9167 APE9-dist-in 7.7646 C1097S None None XRAY 1.7 0.191 0.225 A 353.0 296.0 14 30 22 8 [[1116, 1385]] 1.0 4foc TYR_ALK_HUMAN TYR 1.8e-90 308.8 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4Z55A Q9UM73 1093 1399 1620.0 4LO:1503 Type1 Inactive DFGin 6.2529 14.6352 ABAminus -123.6, 13.8 -145.92, 137.93 -133.07, 27.38 295.45, 90.97 -57.61, -49.96 in-in in 7.4562 Saltbr-in 2.7841 HRD-in -65.39, -47.79 76.59, -11.13 in-out-out SNCioo out-out ActLoopNT-out 6.8722 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.75, -10.47 APE9-dihe-in -67.58, 140.18 APE8-dihe-in -79.19, 59.38 APE8-rot-na 31.88 APE67-dihe-in -66.53, -10.05 -40.3, -48.22 APE12-dist-na 14.8771 APE11-dist-na 15.1593 APE10-dist-na 10.0854 APE9-dist-out 8.0721 S1281G None None XRAY 1.55 0.185 0.208 A 339.0 294.0 13 30 29 1 [[1116, 1385]] 1.0 4z55 TYR_ALK_HUMAN TYR 4.7e-90 307.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 3LCSA Q9UM73 1096 1399 1620.0 STU:1 Type1 Inactive DFGin 6.3299 14.9123 ABAminus -115.64, -37.74 -102.74, 114.2 -112.42, 20.01 289.12, 86.66 -56.01, -38.26 in-in in 7.78 Saltbr-in 2.6618 HRD-in -69.52, -44.32 78.89, -12.54 in-out-out SNCioo out-out ActLoopNT-out 6.7937 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.07, -13.05 APE9-dihe-in -64.04, 139.47 APE8-dihe-in -80.51, 60.39 APE8-rot-na 31.54 APE67-dihe-in -67.01, -14.6 -60.37, -27.86 APE12-dist-na 15.3078 APE11-dist-na 15.5689 APE10-dist-na 10.5385 APE9-dist-out 8.2956 S1281G None None XRAY 1.95 0.196 0.229 A 344.0 304.0 0 30 30 0 [[1116, 1385]] 1.0 3lcs TYR_ALK_HUMAN TYR 5e-90 307.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4MKCA Q9UM73 1093 1401 1620.0 4MK:1503 Type1 Inactive DFGin 6.1419 14.7875 ABAminus -119.13, 7.31 -142.69, 137.29 -134.51, 29.61 298.97, 84.4 -59.55, -42.66 in-in in 7.6556 Saltbr-in 2.8638 HRD-in -66.46, -45.49 70.41, -4.89 in-out-out SNCioo out-out ActLoopNT-out 6.8961 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.61, -14.66 APE9-dihe-in -63.04, 142.03 APE8-dihe-in -82.73, 64.43 APE8-rot-na 33.65 APE67-dihe-in -65.02, -10.82 -49.18, -45.64 APE12-dist-na 14.9176 APE11-dist-na 15.2507 APE10-dist-na 10.2048 APE9-dist-out 8.1176 S1281G None None XRAY 2.01 0.173 0.218 A 367.0 303.0 6 30 30 0 [[1116, 1385]] 1.0 4mkc TYR_ALK_HUMAN TYR 6.2e-90 307.0 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 9GBEA Q9UM73 1086 1401 1620.0 A1IJ8:1501 Type1 Inactive DFGin 6.2263 14.8347 ABAminus -118.03, -13.57 -139.47, 137.54 -132.04, 28.84 289.39, 90.38 -67.89, -35.38 in-in in 7.8497 Saltbr-in 2.7097 HRD-in -70.68, -49.03 81.56, -8.45 in-out-out SNCioo out-out ActLoopNT-out 6.9133 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.96, -12.0 APE9-dihe-in -66.08, 139.0 APE8-dihe-in -79.17, 64.92 APE8-rot-na 34.36 APE67-dihe-in -67.16, -14.31 -60.07, -32.34 APE12-dist-na 14.1672 APE11-dist-na 15.0287 APE10-dist-na 9.8915 APE9-dist-out 8.0702 L1196M,G1202R None None XRAY 1.58 0.186 0.224 A 344.0 304.0 12 30 24 6 [[1116, 1385]] 1.0 9gbe TYR_ALK_HUMAN TYR 3.3e-89 304.6 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4CNHB Q9UM73 1093 1401 1620.0 3U9:2401,3U9:2402 Type1,Allosteric Inactive DFGin 4.3394 12.3272 ABAminus -115.59, -14.06 -164.87, 163.73 -86.41, -10.43 302.46, 115.44 53.37, -130.64 in-in in 8.0724 Saltbr-in 2.6288 HRD-in -84.33, -49.79 83.6, -11.29 in-out-out SNCioo out-out ActLoopNT-out 8.5492 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -91.6, -17.34 APE9-dihe-in -73.51, 138.4 APE8-dihe-in -77.48, 68.43 APE8-rot-na 27.84 APE67-dihe-in -66.22, -13.37 -69.94, -19.9 APE12-dist-na 12.7837 APE11-dist-na 13.4643 APE10-dist-na 8.3849 APE9-dist-out 8.684 None None None XRAY 1.9 0.206 0.25 B 327.0 294.0 15 30 25 5 [[1116, 1385]] 1.0 4cnh TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4JOAA Q9UM73 1107 1398 1620.0 3DK:1501 Type1.5_Front Inactive DFGin 5.6505 15.1801 ABAminus -99.28, -25.44 -116.97, 136.23 -132.09, 28.46 289.09, 82.31 -66.18, -40.48 in-out in 8.5317 Saltbr-out 7.3232 HRD-in -79.35, -45.13 67.79, 9.59 out-out-out SNCooo out-out ActLoopNT-out 6.6325 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -75.97, -11.03 APE9-dihe-in -75.81, 135.85 APE8-dihe-in -79.69, 75.84 APE8-rot-na 32.08 APE67-dihe-in -70.53, -20.07 -69.09, -33.02 APE12-dist-na 999.0 APE11-dist-na 15.0993 APE10-dist-na 10.2802 APE9-dist-out 8.0984 S1281G None None XRAY 2.7 0.253 0.29 A 344.0 251.0 41 30 21 9 [[1116, 1385]] 1.0 4joa TYR_ALK_HUMAN TYR 5e-90 307.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 2YJRA Q9UM73 1101 1402 1620.0 No_ligand No_ligand Inactive DFGin 6.3091 14.7033 None -109.22, -156.6 -24.57, 131.48 -106.45, 12.37 294.91, 66.22 -54.96, -56.35 in-in in 7.9428 Saltbr-in 3.1237 HRD-in -78.17, -44.51 78.03, -12.49 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -91.23, -22.26 APE9-dihe-in -61.19, 130.79 APE8-dihe-in -74.37, 65.56 APE8-rot-na 28.22 APE67-dihe-in -67.2, -14.23 -60.39, -32.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8552 F1174L None None XRAY 1.9 0.221 0.281 A 342.0 281.0 21 30 16 14 [[1116, 1385]] 1.0 2yjr TYR_ALK_HUMAN TYR 1.3e-90 309.2 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 6EDLA Q9UM73 1093 1399 1620.0 J4M:1500 Type1 Inactive DFGin 5.7419 13.9986 None -126.77, 7.53 -146.28, 139.77 -129.2, 999.0 286.43, 88.97 999.0, 999.0 in-in in 8.043 Saltbr-in 3.2026 HRD-in -75.33, -45.54 75.3, -3.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -90.79, -15.28 APE9-dihe-in -62.49, 138.06 APE8-dihe-in -76.58, 62.31 APE8-rot-na 33.87 APE67-dihe-in -71.34, -10.1 -42.44, -41.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1154 None None None XRAY 2.799 0.231 0.282 A 322.0 282.0 25 30 14 16 [[1116, 1385]] 1.0 6edl TYR_ALK_HUMAN TYR 1.3e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 5IMXA Q9UM73 1109 1400 1620.0 CZ4:1501 Type1 Inactive DFGin 5.0344 14.4493 None -109.53, -14.09 -148.27, 147.07 -105.7, 146.52 283.91, 86.87 -67.35, -107.72 in-in in 8.0283 Saltbr-in 2.5042 HRD-in -65.65, -55.77 80.57, -2.35 in-out-out SNCioo out-out ActLoopNT-out 7.5579 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -82.05, -3.8 APE9-dihe-in -82.72, 146.31 APE8-dihe-in -87.12, 68.37 APE8-rot-na 16.28 APE67-dihe-in -69.01, -16.06 -50.43, -36.09 APE12-dist-na 10.9042 APE11-dist-na 15.5625 APE10-dist-na 10.6323 APE9-dist-in 7.972 None None None XRAY 2.12 0.213 0.259 A 327.0 266.0 26 30 20 10 [[1116, 1385]] 1.0 5imx TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4DCEA Q9UM73 1093 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.6296 13.8228 None -137.27, 16.47 -161.52, 152.14 -94.73, 164.26 291.72, 122.64 -76.17, 999.0 in-in in 8.4822 Saltbr-in 2.8829 HRD-in -75.4, -48.78 85.77, -10.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.83, -20.84 APE9-dihe-in -55.51, 136.7 APE8-dihe-in -77.28, 70.08 APE8-rot-na 28.6 APE67-dihe-in -68.31, -8.92 -56.77, -41.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9739 C1097S None None XRAY 2.03 0.211 0.256 A 333.0 288.0 22 30 16 14 [[1116, 1385]] 1.0 4dce TYR_ALK_HUMAN TYR 1.5e-90 309.0 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4DCEB Q9UM73 1094 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.7474 13.6282 None -141.04, 18.73 -165.26, 150.02 -96.5, 167.37 286.77, 120.17 -70.38, 999.0 in-in in 8.5634 Saltbr-in 2.9896 HRD-in -72.56, -48.26 83.87, -14.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.41, -12.56 APE9-dihe-in -59.98, 136.0 APE8-dihe-in -80.48, 64.18 APE8-rot-na 31.8 APE67-dihe-in -66.1, -14.3 -52.07, -41.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.7127 C1097S None None XRAY 2.03 0.211 0.256 B 333.0 284.0 25 30 15 15 [[1116, 1385]] 1.0 4dce TYR_ALK_HUMAN TYR 1.5e-90 309.0 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 5IUGA Q9UM73 1093 1404 1620.0 729:1501 Type2 Inactive DFGout 14.1533 9.9993 BBAminus -131.11, -160.99 -160.87, 113.54 -82.67, -13.49 278.51, 100.05 82.21, 14.97 in-in in 7.6694 Saltbr-in 3.0741 HRD-in -68.79, -47.96 74.11, -0.87 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.37, -10.99 APE9-dihe-in -66.27, 131.08 APE8-dihe-in -74.93, 62.41 APE8-rot-na 32.11 APE67-dihe-in -72.28, -10.91 -51.72, -32.16 APE12-dist-na 14.9994 APE11-dist-na 12.8171 APE10-dist-na 7.8996 APE9-dist-out 8.4198 C1097S None None XRAY 1.93 0.184 0.211 A 327.0 285.0 27 30 18 12 [[1116, 1385]] 1.0 5iug TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 5IUHA Q9UM73 1093 1404 1620.0 34Y:1501 Type2 Inactive DFGout 14.2321 10.118 BBAminus -138.56, -161.58 -159.14, 110.88 -77.24, -9.47 279.89, 100.17 78.06, 14.37 in-in in 7.6196 Saltbr-in 2.9882 HRD-in -72.63, -47.58 76.22, -3.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -97.17, -17.0 APE9-dihe-in -66.13, 131.14 APE8-dihe-in -77.12, 65.41 APE8-rot-na 31.95 APE67-dihe-in -67.53, -10.9 -52.9, -35.57 APE12-dist-na 14.94 APE11-dist-na 12.9611 APE10-dist-na 8.2239 APE9-dist-out 8.5443 C1097S None None XRAY 2.1 0.183 0.221 A 327.0 285.0 27 30 17 13 [[1116, 1385]] 1.0 5iuh TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK 4FNYA Q9UM73 1103 1404 1620.0 I3K:1501 Type2 Inactive DFGout 14.1839 10.0885 None -127.21, -165.1 -161.64, 122.7 -96.04, 999.0 291.91, 90.85 999.0, 999.0 in-in in 7.8988 Saltbr-in 2.5278 HRD-in -68.56, -48.94 76.07, 1.7 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.3, -24.9 APE9-dihe-in -67.06, 137.93 APE8-dihe-in -72.43, 66.19 APE8-rot-na 27.5 APE67-dihe-in -66.24, -16.71 -48.34, -39.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2142 C1097S,R1275Q None None XRAY 2.45 0.196 0.252 A 327.0 273.0 29 30 14 16 [[1116, 1385]] 1.0 4fny TYR_ALK_HUMAN TYR 3.6e-90 307.7 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor

TYR_ALK (ALK tyrosine kinase receptor)

Total number of chains: 68
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 58 85.3% 3LCSA
DFGin None 5 7.4% 2YJRA
DFGin BLAminus 2 2.9% AF-Q9UM73-K1A
DFGout BBAminus 2 2.9% 5IUGA
DFGout None 1 1.5% 4FNYA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ALK ALK_HUMAN AF-Q9UM73-K1A Q9UM73 1108 1393 1620.0 No_ligand No_ligand Active DFGin 5.946 14.3748 BLAminus -128.36, -171.81 51.94, 77.78 -92.22, 15.36 286.64, 85.92 -56.6, -33.49 in-in in 7.9769 Saltbr-in 2.6312 HRD-in -84.5, -39.96 65.84, -13.69 in-in-in SNCiii in-in ActLoopNT-in 2.9075 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.67, 132.62 APE9-dihe-in -132.53, 142.2 APE8-dihe-in -77.98, 67.6 APE8-rot-na 34.24 APE67-dihe-in -67.7, -9.18 -47.25, -44.33 APE12-dist-na 15.1897 APE11-dist-na 9.6169 APE10-dist-na 10.4614 APE9-dist-in 7.2037 None None None AF2 -1.0 1.0 1.0 A 286.0 286.0 0 30 30 0 [[1116, 1385]] 1.0 AF-Q9UM73-K1 Homo sapiens TYR_ALK_HUMAN TYR 8.6e-91 309.7 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN AF-Q9UM73-K3A Q9UM73 1108 1393 1620.0 No_ligand No_ligand Active DFGin 6.0517 13.6075 BLAminus -131.74, -170.01 51.86, 66.91 -83.62, 16.51 291.43, 91.58 -58.46, -31.87 in-in in 8.0792 Saltbr-in 2.6868 HRD-in -85.25, -38.15 64.37, 4.14 in-in-in SNCiii in-in ActLoopNT-in 2.8669 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.58, 98.52 APE9-dihe-in -103.22, 145.61 APE8-dihe-in -72.6, 70.7 APE8-rot-na 33.25 APE67-dihe-in -77.31, -3.9 -52.0, -31.13 APE12-dist-na 16.4672 APE11-dist-na 10.4351 APE10-dist-na 11.2538 APE9-dist-in 7.2852 None None None AF2 -1.0 1.0 1.0 A 286.0 286.0 0 30 30 0 [[1116, 1385]] 1.0 AF-Q9UM73-K3 Homo sapiens TYR_ALK_HUMAN TYR 8.6e-91 309.7 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 3LCTA Q9UM73 1093 1400 1620.0 ADP:1412 ATPlike Inactive DFGin 6.2665 15.1932 ABAminus -127.22, 10.26 -136.37, 129.73 -130.23, 18.7 291.41, 88.16 -49.74, -46.74 in-none in 8.1003 Saltbr-none 999.0 HRD-in -78.72, -45.58 81.21, -3.39 none-out-out SNCnoo out-out ActLoopNT-out 6.8864 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -94.62, -10.42 APE9-dihe-in -67.88, 140.77 APE8-dihe-in -81.63, 62.42 APE8-rot-na 34.08 APE67-dihe-in -66.16, -16.53 -61.79, -27.56 APE12-dist-na 14.7391 APE11-dist-na 15.1116 APE10-dist-na 9.9808 APE9-dist-out 8.0309 S1281G None None XRAY 2.1 0.207 0.255 A 344.0 308.0 0 30 30 0 [[1116, 1385]] 1.0 3lct Homo sapiens TYR_ALK_HUMAN TYR 5e-90 307.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4TT7A Q9UM73 1095 1400 1620.0 COM:61501,COM:61502 Allosteric,Allosteric Inactive DFGin 6.3309 15.1043 ABAminus -129.34, 13.94 -143.37, 136.26 -133.45, 29.15 287.86, 86.47 -61.1, -46.06 in-in in 8.2758 Saltbr-in 2.8991 HRD-in -65.35, -47.66 76.28, -7.96 in-out-out SNCioo out-out ActLoopNT-out 6.7172 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -97.0, -10.73 APE9-dihe-in -72.98, 131.19 APE8-dihe-in -73.54, 64.64 APE8-rot-na 32.16 APE67-dihe-in -68.68, -12.97 -52.76, -40.18 APE12-dist-na 14.9463 APE11-dist-na 15.2582 APE10-dist-na 10.0877 APE9-dist-out 8.1337 None None None XRAY 2.1 0.195 0.244 A 325.0 290.0 16 30 28 2 [[1116, 1385]] 1.0 4tt7 Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 7JY4A Q9UM73 1096 1399 1620.0 W47:1701,W47:1702 Allosteric,Type1 Inactive DFGin 5.9202 14.5186 ABAminus -113.43, -9.3 -142.4, 138.16 -131.48, 29.53 294.61, 83.59 -63.18, -27.52 in-out in 7.579 Saltbr-out 4.2893 HRD-in -66.41, -52.1 72.58, 14.97 out-out-out SNCooo out-out ActLoopNT-out 6.6647 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.55, -8.29 APE9-dihe-in -68.93, 134.74 APE8-dihe-in -72.25, 67.62 APE8-rot-na 30.54 APE67-dihe-in -68.71, -7.15 -58.46, -37.5 APE12-dist-na 14.864 APE11-dist-na 15.6375 APE10-dist-na 10.484 APE9-dist-out 8.4718 None None None XRAY 2.42 0.221 0.255 A 322.0 290.0 14 30 23 7 [[1116, 1385]] 1.0 7jy4 Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 2YHVA Q9UM73 1093 1401 1620.0 No_ligand No_ligand Inactive DFGin 6.2916 15.188 ABAminus -123.67, -1.11 -136.06, 135.4 -132.07, 27.87 288.99, 87.09 -68.12, -28.8 in-out in 8.0074 Saltbr-out 4.973 HRD-in -77.85, -44.61 80.59, -11.15 out-out-out SNCooo out-out ActLoopNT-out 6.9708 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.52, -6.03 APE9-dihe-in -64.98, 136.8 APE8-dihe-in -78.21, 58.76 APE8-rot-na 28.31 APE67-dihe-in -70.14, -11.55 -58.4, -31.21 APE12-dist-na 14.5833 APE11-dist-na 15.0032 APE10-dist-na 10.0023 APE9-dist-out 8.1027 L1196M None None XRAY 1.9 0.206 0.238 A 342.0 292.0 17 30 24 6 [[1116, 1385]] 1.0 2yhv Homo sapiens TYR_ALK_HUMAN TYR 6e-91 310.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4ANLA Q9UM73 1094 1402 1620.0 No_ligand No_ligand Inactive DFGin 6.3187 15.074 ABAminus -122.56, -44.06 -97.45, 124.8 -122.56, 30.81 292.45, 83.3 -66.54, -36.82 in-out in 8.0229 Saltbr-out 4.8522 HRD-in -74.81, -43.42 79.26, -10.5 out-out-out SNCooo out-out ActLoopNT-out 6.9758 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.21, -6.47 APE9-dihe-in -62.46, 134.19 APE8-dihe-in -75.42, 58.77 APE8-rot-na 29.27 APE67-dihe-in -71.73, -7.68 -54.8, -34.96 APE12-dist-na 14.3762 APE11-dist-na 14.7897 APE10-dist-na 9.8499 APE9-dist-out 8.0398 G1269A None None XRAY 1.7 0.202 0.216 A 342.0 293.0 16 30 24 6 [[1116, 1385]] 1.0 4anl Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4FNWA Q9UM73 1084 1405 1620.0 No_ligand No_ligand Inactive DFGin 6.2663 14.909 ABAminus -118.46, -25.35 -118.23, 130.17 -123.97, 30.37 289.23, 85.23 -66.19, -35.54 in-in in 7.9726 Saltbr-in 3.2706 HRD-in -71.6, -47.27 80.64, -6.43 in-out-out SNCioo out-out ActLoopNT-out 7.0091 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.87, -11.88 APE9-dihe-in -57.72, 142.89 APE8-dihe-in -82.66, 63.25 APE8-rot-na 32.43 APE67-dihe-in -71.06, -7.27 -50.06, -41.71 APE12-dist-na 11.9215 APE11-dist-na 15.1006 APE10-dist-na 10.0549 APE9-dist-in 7.9156 C1097S,F1174L None None XRAY 1.75 0.181 0.203 A 327.0 304.0 18 30 22 8 [[1116, 1385]] 1.0 4fnw Homo sapiens TYR_ALK_HUMAN TYR 1.1e-90 309.4 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4FNXA Q9UM73 1093 1404 1620.0 No_ligand No_ligand Inactive DFGin 6.0557 14.8296 ABAminus -115.68, -17.57 -132.37, 141.55 -132.11, 50.23 294.37, 89.4 -81.69, -11.71 in-in in 7.8786 Saltbr-in 2.8996 HRD-in -67.87, -45.92 63.48, 21.39 in-out-out SNCioo out-out ActLoopNT-out 8.7961 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.41, -1.04 APE9-dihe-in -70.97, 126.88 APE8-dihe-in -77.01, 61.37 APE8-rot-na 28.92 APE67-dihe-in -68.85, -9.84 -51.53, -36.34 APE12-dist-na 12.798 APE11-dist-na 16.4257 APE10-dist-na 11.5513 APE9-dist-out 8.7707 C1097S,R1275Q None None XRAY 1.7 0.196 0.23 A 327.0 292.0 20 30 21 9 [[1116, 1385]] 1.0 4fnx Homo sapiens TYR_ALK_HUMAN TYR 3.6e-90 307.7 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 6CDTA Q9UM73 1093 1400 1620.0 No_ligand No_ligand Inactive DFGin 6.3001 15.1244 ABAminus -123.35, -15.42 -125.06, 128.52 -124.36, 30.18 290.06, 83.02 -64.75, -38.93 in-out in 7.9953 Saltbr-out 4.9785 HRD-in -72.97, -44.41 80.06, -9.45 out-out-out SNCooo out-out ActLoopNT-out 7.0241 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -101.22, -7.31 APE9-dihe-in -65.06, 137.47 APE8-dihe-in -74.57, 60.9 APE8-rot-na 29.07 APE67-dihe-in -75.35, -6.12 -48.18, -42.21 APE12-dist-na 14.4527 APE11-dist-na 14.7792 APE10-dist-na 9.783 APE9-dist-in 7.8611 None None None XRAY 1.8 0.196 0.226 A 327.0 292.0 16 30 24 6 [[1116, 1385]] 1.0 6cdt Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 2YJSA Q9UM73 1094 1402 1620.0 No_ligand No_ligand Inactive DFGin 5.9329 15.0657 ABAminus -121.83, -11.53 -129.45, 132.48 -129.61, 30.1 290.02, 84.24 -67.53, -32.65 in-out in 8.5294 Saltbr-out 3.7588 HRD-in -74.02, -46.25 80.81, -7.98 out-out-out SNCooo out-out ActLoopNT-out 6.9634 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -95.71, -13.28 APE9-dihe-in -61.54, 135.1 APE8-dihe-in -77.63, 61.25 APE8-rot-na 30.06 APE67-dihe-in -69.46, -13.22 -55.44, -32.78 APE12-dist-na 14.1592 APE11-dist-na 15.2679 APE10-dist-na 10.2679 APE9-dist-out 8.1891 C1156Y None None XRAY 1.9 0.211 0.243 A 342.0 290.0 19 30 22 8 [[1116, 1385]] 1.0 2yjs Homo sapiens TYR_ALK_HUMAN TYR 2.2e-90 308.4 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 3L9PA Q9UM73 1093 1400 1620.0 No_ligand No_ligand Inactive DFGin 6.2188 15.1559 ABAminus -126.0, -1.93 -131.15, 131.2 -131.41, 25.42 291.27, 88.64 -59.73, -44.21 in-none in 7.9825 Saltbr-none 999.0 HRD-in -69.61, -44.54 77.55, -8.47 none-out-out SNCnoo out-out ActLoopNT-out 6.8826 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.3, -11.47 APE9-dihe-in -69.19, 138.58 APE8-dihe-in -80.43, 62.6 APE8-rot-na 32.84 APE67-dihe-in -67.59, -13.49 -45.09, -43.43 APE12-dist-na 14.948 APE11-dist-na 15.1102 APE10-dist-na 10.0091 APE9-dist-in 7.9038 S1281G None None XRAY 1.8 0.192 0.226 A 367.0 303.0 5 30 30 0 [[1116, 1385]] 1.0 3l9p Homo sapiens TYR_ALK_HUMAN TYR 6.2e-90 307.0 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4ANSA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 6.2485 15.1618 ABAminus -128.23, -41.44 -98.11, 120.9 -117.53, 30.59 287.81, 85.26 -66.49, -38.26 in-out in 8.265 Saltbr-out 4.8918 HRD-in -72.85, -44.3 78.64, -9.03 out-out-out SNCooo out-out ActLoopNT-out 6.908 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.15, -7.92 APE9-dihe-in -66.26, 134.84 APE8-dihe-in -77.14, 60.8 APE8-rot-na 30.33 APE67-dihe-in -70.27, -10.51 -58.92, -29.59 APE12-dist-na 14.6611 APE11-dist-na 14.8834 APE10-dist-na 9.857 APE9-dist-out 8.0387 L1196M,G1269A None None XRAY 1.85 0.201 0.231 A 342.0 294.0 16 30 24 6 [[1116, 1385]] 1.0 4ans Homo sapiens TYR_ALK_HUMAN TYR 5.2e-91 310.5 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 2YFXA Q9UM73 1093 1401 1620.0 VGH:9000 Type1 Inactive DFGin 6.2206 14.8808 ABAminus -122.22, -28.6 -114.9, 132.72 -127.11, 33.52 293.03, 85.04 -65.89, -37.73 in-out in 7.9144 Saltbr-out 4.7498 HRD-in -73.95, -43.63 78.32, -9.23 out-out-out SNCooo out-out ActLoopNT-out 6.9557 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.12, -9.34 APE9-dihe-in -61.51, 137.47 APE8-dihe-in -77.72, 57.54 APE8-rot-na 29.78 APE67-dihe-in -70.24, -8.94 -56.4, -32.44 APE12-dist-na 14.505 APE11-dist-na 14.9332 APE10-dist-na 9.9197 APE9-dist-out 8.0505 L1196M None None XRAY 1.7 0.208 0.234 A 327.0 293.0 16 30 24 6 [[1116, 1385]] 1.0 2yfx Homo sapiens TYR_ALK_HUMAN TYR 5.1e-91 310.5 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4CLJA Q9UM73 1094 1402 1620.0 5P8:2402 Type1 Inactive DFGin 6.2031 14.8054 ABAminus -125.62, -0.02 -140.07, 135.04 -130.43, 32.34 295.46, 85.14 -65.98, -39.5 in-in in 8.0111 Saltbr-in 2.7108 HRD-in -71.97, -45.96 80.49, -8.87 in-out-out SNCioo out-out ActLoopNT-out 6.9627 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.51, -5.34 APE9-dihe-in -68.88, 140.43 APE8-dihe-in -76.17, 58.33 APE8-rot-na 29.07 APE67-dihe-in -72.79, -6.46 -47.28, -42.69 APE12-dist-na 14.5577 APE11-dist-na 14.8066 APE10-dist-na 9.7887 APE9-dist-in 7.9372 L1196M None None XRAY 1.66 0.197 0.229 A 327.0 296.0 13 30 24 6 [[1116, 1385]] 1.0 4clj Homo sapiens TYR_ALK_HUMAN TYR 5.1e-91 310.5 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4CD0A Q9UM73 1094 1402 1620.0 AWJ:1500 Type1 Inactive DFGin 6.2095 14.8068 ABAminus -124.48, -7.47 -131.66, 141.46 -133.85, 29.84 290.85, 86.66 -65.46, -35.12 in-in in 7.7112 Saltbr-in 2.7447 HRD-in -77.45, -47.18 84.39, -11.38 in-out-out SNCioo out-out ActLoopNT-out 6.8871 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.9, -13.71 APE9-dihe-in -68.46, 134.66 APE8-dihe-in -73.25, 65.7 APE8-rot-na 30.38 APE67-dihe-in -69.89, -9.61 -53.98, -40.39 APE12-dist-na 14.7046 APE11-dist-na 14.9102 APE10-dist-na 9.7245 APE9-dist-in 7.9756 L1196M None None XRAY 2.23 0.198 0.25 A 342.0 296.0 13 30 24 6 [[1116, 1385]] 1.0 4cd0 Homo sapiens TYR_ALK_HUMAN TYR 6e-91 310.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4ANQA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 6.2087 14.9738 ABAminus -128.3, -36.39 -101.79, 127.42 -123.56, 31.99 288.31, 85.14 -69.12, -35.87 in-out in 8.2697 Saltbr-out 4.7889 HRD-in -73.02, -46.15 80.91, -7.4 out-out-out SNCooo out-out ActLoopNT-out 6.947 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -98.41, -8.07 APE9-dihe-in -67.75, 134.94 APE8-dihe-in -74.89, 59.28 APE8-rot-na 29.64 APE67-dihe-in -70.46, -10.96 -58.56, -29.68 APE12-dist-na 14.7237 APE11-dist-na 14.9551 APE10-dist-na 9.9221 APE9-dist-out 8.0186 G1269A None None XRAY 1.76 0.201 0.217 A 342.0 294.0 16 30 24 6 [[1116, 1385]] 1.0 4anq Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 5AA9A Q9UM73 1093 1402 1620.0 5P8:2402 Type1 Inactive DFGin 6.1824 14.8906 ABAminus -123.86, -6.83 -134.63, 136.55 -132.06, 29.87 289.56, 85.44 -66.04, -35.64 in-out in 8.1567 Saltbr-out 4.5375 HRD-in -75.17, -44.12 79.72, -10.27 out-out-out SNCooo out-out ActLoopNT-out 6.8482 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.37, -11.88 APE9-dihe-in -67.63, 135.25 APE8-dihe-in -76.86, 63.04 APE8-rot-na 30.41 APE67-dihe-in -70.03, -11.65 -60.61, -27.66 APE12-dist-na 14.9157 APE11-dist-na 15.2297 APE10-dist-na 10.0961 APE9-dist-out 8.1585 L1198F None None XRAY 1.93 0.201 0.237 A 327.0 296.0 14 30 24 6 [[1116, 1385]] 1.0 5aa9 Homo sapiens TYR_ALK_HUMAN TYR 4.4e-91 310.7 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 5AAAA Q9UM73 1093 1401 1620.0 VGH:9000 Type1 Inactive DFGin 6.2088 14.916 ABAminus -119.08, -27.29 -116.14, 136.82 -130.64, 32.52 289.46, 85.69 -67.72, -37.15 in-out in 7.9686 Saltbr-out 4.6697 HRD-in -74.4, -45.03 79.43, -9.27 out-out-out SNCooo out-out ActLoopNT-out 6.8981 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.98, -3.96 APE9-dihe-in -73.12, 136.6 APE8-dihe-in -77.4, 61.62 APE8-rot-na 28.9 APE67-dihe-in -71.26, -10.51 -60.21, -28.6 APE12-dist-na 14.5554 APE11-dist-na 14.8493 APE10-dist-na 9.8001 APE9-dist-out 8.0299 L1198F None None XRAY 1.73 0.201 0.206 A 327.0 295.0 14 30 24 6 [[1116, 1385]] 1.0 5aaa Homo sapiens TYR_ALK_HUMAN TYR 4.4e-91 310.7 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 5AA8A Q9UM73 1093 1402 1620.0 5P8:2402 Type1 Inactive DFGin 6.0863 14.918 ABAminus -121.09, -8.69 -130.71, 131.76 -128.08, 33.6 288.19, 85.62 -75.96, -22.55 in-out in 8.2447 Saltbr-out 4.485 HRD-in -76.73, -45.37 80.25, -8.63 out-out-out SNCooo out-out ActLoopNT-out 6.7988 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.53, -15.21 APE9-dihe-in -61.78, 135.61 APE8-dihe-in -77.32, 62.22 APE8-rot-na 29.6 APE67-dihe-in -71.9, -11.44 -60.22, -27.26 APE12-dist-na 14.6816 APE11-dist-na 15.5516 APE10-dist-na 10.4812 APE9-dist-out 8.1876 C1156Y,L1198F None None XRAY 1.86 0.209 0.233 A 327.0 293.0 17 30 24 6 [[1116, 1385]] 1.0 5aa8 Homo sapiens TYR_ALK_HUMAN TYR 5.9e-91 310.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 5AABA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 5.962 14.9414 ABAminus -122.06, -28.4 -115.22, 132.25 -127.31, 26.85 289.37, 81.1 -65.12, -33.9 in-out in 8.0829 Saltbr-out 4.2699 HRD-in -73.35, -48.11 83.65, -8.17 out-out-out SNCooo out-out ActLoopNT-out 6.9633 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.88, -2.64 APE9-dihe-in -78.59, 133.38 APE8-dihe-in -74.05, 62.22 APE8-rot-na 30.08 APE67-dihe-in -71.71, -12.93 -64.03, -23.79 APE12-dist-na 15.1004 APE11-dist-na 15.2049 APE10-dist-na 10.0874 APE9-dist-out 8.0863 C1156Y,L1198F None None XRAY 2.2 0.211 0.246 A 327.0 294.0 16 30 24 6 [[1116, 1385]] 1.0 5aab Homo sapiens TYR_ALK_HUMAN TYR 5.9e-91 310.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 6MX8A Q9UM73 1094 1400 1620.0 6GY:1500 Type1 Inactive DFGin 6.1418 14.6623 ABAminus -114.12, -38.77 -118.14, 138.18 -129.19, 26.62 289.5, 87.05 -61.73, -41.9 in-in in 7.7858 Saltbr-in 3.2344 HRD-in -72.93, -50.14 84.31, -4.9 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.89, -3.2 APE9-dihe-in -73.94, 138.53 APE8-dihe-in -85.7, 68.86 APE8-rot-na 37.09 APE67-dihe-in -74.13, -8.15 -48.67, -39.52 APE12-dist-na 14.2439 APE11-dist-na 15.1838 APE10-dist-na 10.0835 APE9-dist-out 8.1676 None None None XRAY 1.96 0.185 0.227 A 307.0 282.0 25 30 17 13 [[1116, 1385]] 1.0 6mx8 Homo sapiens TYR_ALK_HUMAN TYR 1.1e-90 309.4 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 2XB7A Q9UM73 1095 1401 1620.0 GUI:1501 Type1 Inactive DFGin 5.7305 14.5992 ABAminus -132.42, -0.18 -141.44, 142.16 -131.03, 43.77 292.96, 89.17 -72.28, -38.54 in-in in 7.5319 Saltbr-in 3.1842 HRD-in -87.04, -46.67 85.76, -13.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.32, -3.08 APE9-dihe-in -73.74, 136.06 APE8-dihe-in -78.24, 56.9 APE8-rot-na 30.55 APE67-dihe-in -70.57, -6.09 -40.69, -40.8 APE12-dist-na 999.0 APE11-dist-na 15.2726 APE10-dist-na 10.496 APE9-dist-out 8.3356 None None None XRAY 2.5 0.195 0.243 A 315.0 286.0 21 30 16 14 [[1116, 1385]] 1.0 2xb7 Homo sapiens TYR_ALK_HUMAN TYR 1.2e-90 309.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 2XBAA Q9UM73 1095 1402 1620.0 571:1501 Type1 Inactive DFGin 6.0851 14.8742 ABAminus -122.73, -16.28 -123.08, 138.16 -132.25, 31.45 293.73, 90.75 -70.57, -36.09 in-in in 7.9954 Saltbr-in 2.825 HRD-in -75.43, -45.29 77.63, -4.66 in-out-out SNCioo out-out ActLoopNT-out 6.9938 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.39, 0.87 APE9-dihe-in -70.63, 140.95 APE8-dihe-in -81.29, 62.03 APE8-rot-na 33.35 APE67-dihe-in -68.85, -9.81 -51.55, -41.48 APE12-dist-na 999.0 APE11-dist-na 14.8997 APE10-dist-na 9.9146 APE9-dist-out 8.1052 None None None XRAY 1.95 0.195 0.229 A 315.0 284.0 24 30 20 10 [[1116, 1385]] 1.0 2xba Homo sapiens TYR_ALK_HUMAN TYR 1.2e-90 309.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 5FTOA Q9UM73 1094 1401 1620.0 YMX:62402 Type1 Inactive DFGin 6.6137 15.1027 ABAminus -123.37, 0.05 -137.72, 139.58 -135.41, 24.82 289.1, 90.09 -60.28, -46.38 in-in in 7.802 Saltbr-in 2.7128 HRD-in -72.55, -46.15 82.21, -13.13 in-out-out SNCioo out-out ActLoopNT-out 7.0886 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -91.32, -8.05 APE9-dihe-in -57.49, 136.7 APE8-dihe-in -78.81, 60.16 APE8-rot-na 28.18 APE67-dihe-in -67.52, -8.47 -48.73, -45.52 APE12-dist-na 11.5172 APE11-dist-na 14.8572 APE10-dist-na 9.821 APE9-dist-in 7.9666 None None None XRAY 2.22 0.199 0.257 A 315.0 297.0 11 30 23 7 [[1116, 1385]] 1.0 5fto Homo sapiens TYR_ALK_HUMAN TYR 1.2e-90 309.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 5FTQA Q9UM73 1094 1401 1620.0 U4W:62402 Type1 Inactive DFGin 6.5385 14.8246 ABAminus -118.64, -8.41 -138.53, 135.08 -126.73, 26.7 295.74, 85.6 -58.63, -49.74 in-in in 7.6052 Saltbr-in 2.5791 HRD-in -70.78, -46.77 80.03, 2.04 in-out-out SNCioo out-out ActLoopNT-out 6.9291 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.78, -4.85 APE9-dihe-in -67.75, 140.01 APE8-dihe-in -77.42, 62.81 APE8-rot-na 24.56 APE67-dihe-in -73.5, -8.73 -54.41, -36.36 APE12-dist-na 12.6879 APE11-dist-na 14.9562 APE10-dist-na 9.9213 APE9-dist-in 7.795 None None None XRAY 1.7 0.175 0.22 A 315.0 292.0 16 30 22 8 [[1116, 1385]] 1.0 5ftq Homo sapiens TYR_ALK_HUMAN TYR 1.2e-90 309.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 8ARJA Q9UM73 1103 1399 1620.0 NRR:1501 Type1 Inactive DFGin 6.1187 14.5245 ABAminus -117.07, -37.76 -110.06, 107.52 -111.08, 38.44 282.92, 90.71 -87.79, -43.75 in-in in 7.8615 Saltbr-in 2.577 HRD-in -71.95, -46.72 76.96, -5.2 in-out-out SNCioo out-out ActLoopNT-out 6.5525 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -98.2, -2.7 APE9-dihe-in -71.32, 134.53 APE8-dihe-in -74.4, 64.1 APE8-rot-na 36.74 APE67-dihe-in -65.93, -15.67 -63.14, -27.35 APE12-dist-na 15.6023 APE11-dist-na 15.7953 APE10-dist-na 10.5703 APE9-dist-out 8.4005 None None None XRAY 1.645 0.198 0.229 A 321.0 275.0 22 30 22 8 [[1116, 1385]] 1.0 8arj Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.2 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 6E0RA Q9UM73 1099 1399 1620.0 HKJ:1500 Type1 Inactive DFGin 5.9898 14.1302 ABAminus -126.54, 6.88 -146.63, 139.75 -129.52, 23.79 286.55, 86.22 -54.44, -45.81 in-out in 8.2911 Saltbr-out 4.4908 HRD-in -74.7, -43.96 75.16, -3.83 out-out-none SNCoon out-none ActLoopNT-out 6.4909 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -139.14 APE9-dihe-in -62.89, 135.23 APE8-dihe-in -79.57, 61.66 APE8-rot-na 34.01 APE67-dihe-in -70.37, -9.48 -43.47, -41.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.8829 APE9-dist-in 7.8082 None None None XRAY 2.303 0.241 0.296 A 322.0 279.0 22 30 19 11 [[1116, 1385]] 1.0 6e0r Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 6EBWA Q9UM73 1096 1399 1620.0 J3Y:1500 Type1 Inactive DFGin 6.3319 14.7708 ABAminus -124.53, 13.61 -158.52, 147.01 -134.91, 49.92 284.01, 90.06 -74.0, -48.2 in-out in 7.7246 Saltbr-out 5.1352 HRD-in -83.27, -44.43 72.92, 3.22 out-out-none SNCoon out-none ActLoopNT-out 7.088 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 149.36 APE8-dihe-in -68.97, 75.32 APE8-rot-na 28.29 APE67-dihe-in -64.76, -14.09 -59.15, -42.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.811 None None None XRAY 2.455 0.246 0.286 A 322.0 277.0 24 30 16 14 [[1116, 1385]] 1.0 6ebw Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 7JYRA Q9UM73 1095 1399 1620.0 VTA:1601 Type1 Inactive DFGin 6.0368 14.6472 ABAminus -117.25, -3.0 -143.43, 138.22 -132.95, 32.31 290.25, 83.3 -65.6, -36.91 in-out in 7.9182 Saltbr-out 4.7574 HRD-in -74.08, -42.05 82.36, -13.99 out-out-out SNCooo out-out ActLoopNT-out 6.9088 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.47, -3.99 APE9-dihe-in -74.12, 138.94 APE8-dihe-in -75.24, 67.71 APE8-rot-na 31.71 APE67-dihe-in -73.48, -9.59 -58.72, -34.79 APE12-dist-na 15.1778 APE11-dist-na 15.6549 APE10-dist-na 10.5004 APE9-dist-out 8.4538 None None None XRAY 2.32 0.216 0.247 A 322.0 287.0 18 30 23 7 [[1116, 1385]] 1.0 7jyr Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 7JYSA Q9UM73 1095 1399 1620.0 VTD:1601 Type1 Inactive DFGin 5.8473 14.4212 ABAminus -117.17, -14.0 -132.7, 135.12 -128.93, 36.18 292.83, 86.2 -69.53, -37.99 in-in in 7.9616 Saltbr-in 2.5387 HRD-in -70.79, -47.81 83.57, -7.04 in-out-out SNCioo out-out ActLoopNT-out 6.9537 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -114.43, -7.14 APE9-dihe-in -64.31, 136.8 APE8-dihe-in -71.91, 66.98 APE8-rot-na 26.54 APE67-dihe-in -68.83, -10.73 -59.12, -37.36 APE12-dist-na 15.097 APE11-dist-na 15.4959 APE10-dist-na 10.3537 APE9-dist-out 8.1897 None None None XRAY 2.22 0.216 0.253 A 322.0 281.0 24 30 23 7 [[1116, 1385]] 1.0 7jys Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 7JYTA Q9UM73 1095 1399 1620.0 VRM:1502 Type1 Inactive DFGin 5.9774 14.4605 ABAminus -124.69, -2.73 -143.22, 137.8 -131.88, 32.76 291.21, 85.91 -67.73, -37.01 in-out in 7.9242 Saltbr-out 5.3271 HRD-in -79.43, -44.52 77.34, -3.4 out-out-out SNCooo out-out ActLoopNT-out 6.8231 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -112.03, -10.17 APE9-dihe-in -61.0, 135.32 APE8-dihe-in -73.73, 64.74 APE8-rot-na 29.73 APE67-dihe-in -69.91, -11.24 -57.53, -36.41 APE12-dist-na 15.0412 APE11-dist-na 15.5277 APE10-dist-na 10.358 APE9-dist-out 8.1429 None None None XRAY 2.0 0.209 0.224 A 322.0 281.0 24 30 23 7 [[1116, 1385]] 1.0 7jyt Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 2XP2A Q9UM73 1093 1401 1620.0 VGH:9000 Type1 Inactive DFGin 6.01 14.8527 ABAminus -116.89, -30.31 -113.6, 135.35 -129.42, 33.32 290.86, 85.52 -68.93, -36.66 in-out in 8.312 Saltbr-out 4.8435 HRD-in -70.6, -46.14 82.26, -7.39 out-out-out SNCooo out-out ActLoopNT-out 6.7853 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -14.78 APE9-dihe-in -71.8, 131.97 APE8-dihe-in -75.49, 62.54 APE8-rot-na 30.87 APE67-dihe-in -72.66, -13.49 -62.38, -23.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.1483 APE9-dist-out 8.2573 None None None XRAY 1.9 0.207 0.252 A 327.0 289.0 20 30 21 9 [[1116, 1385]] 1.0 2xp2 Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4CCBA Q9UM73 1093 1401 1620.0 OFG:2401 Type1 Inactive DFGin 6.0497 14.7677 ABAminus -119.22, -9.24 -133.44, 139.2 -130.65, 36.27 292.81, 84.36 -70.77, -32.92 in-in in 7.8494 Saltbr-in 2.9192 HRD-in -75.15, -47.62 82.69, -9.54 in-out-none SNCion out-none ActLoopNT-out 6.8955 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -19.77 APE9-dihe-in -65.32, 136.43 APE8-dihe-in -75.25, 61.07 APE8-rot-na 30.01 APE67-dihe-in -69.24, -12.29 -57.16, -31.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.9496 APE9-dist-in 7.9084 None None None XRAY 2.03 0.202 0.235 A 327.0 291.0 18 30 21 9 [[1116, 1385]] 1.0 4ccb Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4CCUA Q9UM73 1093 1402 1620.0 AWF:1500 Type1 Inactive DFGin 6.0199 14.6231 ABAminus -118.73, -9.8 -132.17, 139.04 -133.56, 37.48 295.42, 86.35 -74.53, -27.89 in-out in 8.2766 Saltbr-out 4.6887 HRD-in -77.94, -47.73 82.62, -10.67 out-out-out SNCooo out-out ActLoopNT-out 6.8034 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.98, -27.23 APE9-dihe-in -56.62, 135.11 APE8-dihe-in -75.38, 65.75 APE8-rot-na 29.29 APE67-dihe-in -70.29, -14.23 -60.1, -29.45 APE12-dist-na 14.5251 APE11-dist-na 15.1704 APE10-dist-na 10.0283 APE9-dist-in 7.7958 None None None XRAY 2.0 0.202 0.233 A 327.0 293.0 17 30 24 6 [[1116, 1385]] 1.0 4ccu Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4CLIA Q9UM73 1093 1401 1620.0 5P8:2401 Type1 Inactive DFGin 6.1037 14.6636 ABAminus -126.26, -5.06 -135.36, 136.5 -131.98, 39.01 293.42, 86.05 -79.91, -26.98 in-out in 8.3036 Saltbr-out 4.5186 HRD-in -75.26, -46.3 81.47, -9.07 out-out-out SNCooo out-out ActLoopNT-out 6.8442 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.34, -12.93 APE9-dihe-in -62.11, 137.41 APE8-dihe-in -77.3, 59.87 APE8-rot-na 29.14 APE67-dihe-in -74.79, -11.71 -58.14, -27.0 APE12-dist-na 14.6641 APE11-dist-na 14.9821 APE10-dist-na 10.0029 APE9-dist-in 7.8293 None None None XRAY 2.05 0.199 0.245 A 327.0 295.0 14 30 24 6 [[1116, 1385]] 1.0 4cli Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4CMOA Q9UM73 1093 1402 1620.0 YPW:2402 Type1 Inactive DFGin 6.1786 14.7285 ABAminus -120.95, -9.17 -132.13, 138.79 -131.64, 32.19 292.59, 86.4 -67.48, -36.83 in-out in 8.1084 Saltbr-out 5.0989 HRD-in -74.69, -45.72 80.53, -9.82 out-out-out SNCooo out-out ActLoopNT-out 6.894 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.18, -16.6 APE9-dihe-in -61.82, 137.9 APE8-dihe-in -75.79, 58.08 APE8-rot-na 29.65 APE67-dihe-in -70.92, -9.19 -55.73, -32.13 APE12-dist-na 14.61 APE11-dist-na 14.9019 APE10-dist-na 9.8208 APE9-dist-in 7.8311 None None None XRAY 2.05 0.199 0.245 A 327.0 296.0 14 30 24 6 [[1116, 1385]] 1.0 4cmo Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4CMTA Q9UM73 1093 1401 1620.0 GWH:2401 Type1 Inactive DFGin 6.2115 14.8303 ABAminus -123.22, -5.39 -133.47, 138.97 -132.82, 32.21 291.71, 85.66 -66.83, -37.56 in-in in 7.927 Saltbr-in 2.6223 HRD-in -73.35, -43.01 78.17, -7.26 in-out-none SNCion out-none ActLoopNT-out 6.9135 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 3.2 APE9-dihe-in -71.77, 138.91 APE8-dihe-in -76.34, 59.3 APE8-rot-na 30.92 APE67-dihe-in -69.85, -8.04 -57.32, -34.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.7928 APE9-dist-in 7.8761 None None None XRAY 1.73 0.214 0.248 A 327.0 288.0 21 30 21 9 [[1116, 1385]] 1.0 4cmt Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4CMUA Q9UM73 1093 1401 1620.0 IV7:2401 Type1 Inactive DFGin 6.2247 14.8479 ABAminus -119.02, -15.67 -129.52, 137.46 -129.87, 35.57 292.32, 83.85 -72.08, -34.25 in-out in 8.2683 Saltbr-out 5.0523 HRD-in -73.08, -46.65 81.42, -8.55 out-out-out SNCooo out-out ActLoopNT-out 6.9437 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -98.74, -12.22 APE9-dihe-in -65.64, 137.39 APE8-dihe-in -75.72, 59.54 APE8-rot-na 29.91 APE67-dihe-in -71.19, -9.41 -57.38, -31.15 APE12-dist-na 14.6694 APE11-dist-na 14.8711 APE10-dist-na 9.8653 APE9-dist-in 7.8939 None None None XRAY 1.8 0.206 0.227 A 327.0 295.0 14 30 24 6 [[1116, 1385]] 1.0 4cmu Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4CNHA Q9UM73 1094 1402 1620.0 3U9:2402 Type1 Inactive DFGin 6.3283 15.0458 ABAminus -121.41, -13.5 -134.76, 134.27 -127.13, 24.83 291.86, 80.94 -58.37, -37.06 in-out in 7.9054 Saltbr-out 4.9159 HRD-in -72.36, -47.54 81.36, -5.81 out-out-none SNCoon out-none ActLoopNT-out 7.0247 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 36.87 APE9-dihe-in -64.44, 124.84 APE8-dihe-in -71.68, 78.76 APE8-rot-na 25.36 APE67-dihe-in -71.29, -8.43 -50.25, -44.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.445 APE9-dist-in 6.8106 None None None XRAY 1.9 0.206 0.25 A 327.0 286.0 23 30 20 10 [[1116, 1385]] 1.0 4cnh Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4CTBA Q9UM73 1093 1402 1620.0 KVC:2402 Type1 Inactive DFGin 6.2156 14.8492 ABAminus -119.67, -9.24 -135.77, 135.53 -130.14, 34.99 293.83, 84.83 -68.92, -36.75 in-in in 7.8013 Saltbr-in 3.0825 HRD-in -73.33, -46.07 82.91, -9.21 in-out-out SNCioo out-out ActLoopNT-out 6.9413 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.19, -13.84 APE9-dihe-in -65.2, 138.92 APE8-dihe-in -74.78, 60.38 APE8-rot-na 30.11 APE67-dihe-in -72.32, -8.28 -56.62, -34.41 APE12-dist-na 14.636 APE11-dist-na 14.9968 APE10-dist-na 9.9651 APE9-dist-out 8.0006 None None None XRAY 1.79 0.21 0.247 A 327.0 293.0 17 30 24 6 [[1116, 1385]] 1.0 4ctb Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4CTCA Q9UM73 1094 1402 1620.0 J99:2402 Type1 Inactive DFGin 6.0868 14.4364 ABAminus -113.76, -13.97 -127.87, 134.88 -130.21, 34.39 296.92, 88.54 -69.58, -32.9 in-out in 7.818 Saltbr-out 4.6632 HRD-in -68.52, -47.86 79.55, -14.18 out-out-out SNCooo out-out ActLoopNT-out 6.6285 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.25, -22.21 APE9-dihe-in -63.2, 137.35 APE8-dihe-in -83.4, 68.98 APE8-rot-na 27.6 APE67-dihe-in -69.91, -15.73 -58.12, -29.13 APE12-dist-na 14.9347 APE11-dist-na 15.2582 APE10-dist-na 10.2032 APE9-dist-in 7.8235 None None None XRAY 2.03 0.194 0.216 A 327.0 289.0 20 30 22 8 [[1116, 1385]] 1.0 4ctc Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 5KZ0A Q9UM73 1093 1401 1620.0 6YL:1501 Type1 Inactive DFGin 5.9216 14.406 ABAminus -133.15, -11.67 -127.06, 138.04 -132.87, 29.16 292.21, 94.94 -79.99, -2.4 in-out in 7.9192 Saltbr-out 4.0839 HRD-in -74.2, -39.11 78.61, -15.85 out-out-out SNCooo out-out ActLoopNT-out 6.8345 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -92.46, -46.15 APE9-dihe-in -45.76, 137.83 APE8-dihe-in -84.92, 73.38 APE8-rot-na 33.7 APE67-dihe-in -73.49, -11.11 -70.16, -20.71 APE12-dist-na 15.231 APE11-dist-na 15.1964 APE10-dist-na 10.0438 APE9-dist-in 7.7877 None None None XRAY 2.3 0.18 0.269 A 327.0 293.0 16 30 22 8 [[1116, 1385]] 1.0 5kz0 Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 7R7KA Q9UM73 1094 1400 1620.0 25J:1501 Type1 Inactive DFGin 6.2963 14.7986 ABAminus -117.03, -7.91 -132.86, 139.73 -133.05, 30.6 293.43, 91.77 -61.89, -44.97 in-out in 7.758 Saltbr-out 4.764 HRD-in -63.52, -48.31 78.95, -7.31 out-out-out SNCooo out-out ActLoopNT-out 6.9056 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.56, -4.43 APE9-dihe-in -73.03, 141.44 APE8-dihe-in -80.52, 63.08 APE8-rot-na 29.68 APE67-dihe-in -66.55, -12.77 -43.97, -45.25 APE12-dist-na 14.1426 APE11-dist-na 14.9269 APE10-dist-na 9.8073 APE9-dist-in 7.9115 None None None XRAY 1.831 0.195 0.221 A 327.0 290.0 17 30 24 6 [[1116, 1385]] 1.0 7r7k Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 7R7RA Q9UM73 1093 1401 1620.0 AWJ:1501 Type1 Inactive DFGin 6.1215 14.6939 ABAminus -114.04, -10.1 -130.71, 138.84 -131.21, 32.52 294.04, 89.2 -62.61, -42.67 in-out in 8.0251 Saltbr-out 4.7495 HRD-in -66.43, -50.15 80.96, -9.24 out-out-out SNCooo out-out ActLoopNT-out 6.8833 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -105.96, -19.38 APE9-dihe-in -67.0, 138.74 APE8-dihe-in -79.51, 69.3 APE8-rot-na 29.25 APE67-dihe-in -68.73, -13.21 -57.11, -32.66 APE12-dist-na 14.4527 APE11-dist-na 14.9728 APE10-dist-na 9.8498 APE9-dist-in 7.7278 None None None XRAY 1.935 0.193 0.227 A 327.0 291.0 18 30 23 7 [[1116, 1385]] 1.0 7r7r Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4FNZA Q9UM73 1093 1402 1620.0 NZF:1501 Type1 Inactive DFGin 5.291 12.7997 ABAminus -135.46, 12.02 -152.76, 153.63 -83.97, -38.55 283.31, 122.35 73.66, 999.0 in-in in 8.5004 Saltbr-in 2.8123 HRD-in -72.66, -49.3 78.9, -9.45 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.65, -24.93 APE9-dihe-in -50.61, 132.71 APE8-dihe-in -79.34, 69.48 APE8-rot-na 27.73 APE67-dihe-in -74.42, -13.21 -56.44, -36.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8304 C1097S None None XRAY 2.6 0.202 0.261 A 327.0 287.0 23 30 15 15 [[1116, 1385]] 1.0 4fnz Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 5IUIA Q9UM73 1089 1400 1620.0 45Q:1501 Type1 Inactive DFGin 6.097 15.0666 ABAminus -115.96, -40.57 -98.03, 131.36 -128.94, 30.02 290.16, 88.83 -67.06, -40.42 in-in in 8.1728 Saltbr-in 2.9353 HRD-in -74.44, -37.49 70.23, -3.09 in-out-out SNCioo out-out ActLoopNT-out 7.0487 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -106.21, -6.36 APE9-dihe-in -64.31, 145.1 APE8-dihe-in -79.79, 58.82 APE8-rot-na 31.57 APE67-dihe-in -70.65, -5.92 -44.41, -46.15 APE12-dist-na 14.4423 APE11-dist-na 15.0558 APE10-dist-na 10.0388 APE9-dist-out 8.1167 C1097S None None XRAY 1.88 0.181 0.205 A 327.0 303.0 9 30 25 5 [[1116, 1385]] 1.0 5iui Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4FODA Q9UM73 1085 1405 1620.0 0UV:1501 Type1 Inactive DFGin 6.303 14.9416 ABAminus -126.17, 8.88 -148.68, 139.13 -133.76, 30.42 294.7, 92.17 -67.04, -41.19 in-in in 7.4866 Saltbr-in 2.605 HRD-in -73.82, -48.62 76.13, -0.28 in-out-out SNCioo out-out ActLoopNT-out 7.025 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -105.69, -7.83 APE9-dihe-in -60.03, 145.3 APE8-dihe-in -82.29, 62.32 APE8-rot-na 33.22 APE67-dihe-in -70.05, -10.83 -47.36, -42.53 APE12-dist-na 11.937 APE11-dist-na 15.0687 APE10-dist-na 10.0107 APE9-dist-in 7.8425 C1097S None None XRAY 2.0 0.18 0.221 A 333.0 308.0 13 30 23 7 [[1116, 1385]] 1.0 4fod Homo sapiens TYR_ALK_HUMAN TYR 1.5e-90 309.0 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 3AOXA Q9UM73 1086 1401 1620.0 EMH:901 Type1 Inactive DFGin 6.4074 14.9437 ABAminus -137.07, 23.28 -158.41, 139.16 -133.43, 27.21 291.39, 95.08 -65.65, -43.18 in-in in 7.6565 Saltbr-in 2.5942 HRD-in -71.98, -46.85 79.15, -6.33 in-out-out SNCioo out-out ActLoopNT-out 6.9548 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -95.63, -6.24 APE9-dihe-in -65.1, 144.04 APE8-dihe-in -84.44, 65.15 APE8-rot-na 34.19 APE67-dihe-in -68.33, -10.93 -51.94, -40.89 APE12-dist-na 11.753 APE11-dist-na 14.9616 APE10-dist-na 9.9208 APE9-dist-in 7.9922 None None None XRAY 1.75 0.17 0.206 A 344.0 298.0 18 30 23 7 [[1116, 1385]] 1.0 3aox Homo sapiens TYR_ALK_HUMAN TYR 1.7e-90 308.8 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 5A9UA Q9UM73 1093 1402 1620.0 5P8:2402 Type1 Inactive DFGin 6.068 14.6566 ABAminus -124.48, -3.05 -136.25, 135.66 -131.11, 34.63 291.44, 81.89 -72.61, -25.01 in-out in 8.1331 Saltbr-out 3.8384 HRD-in -74.43, -46.73 80.61, -9.35 out-out-out SNCooo out-out ActLoopNT-out 6.8438 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.6, -12.67 APE9-dihe-in -61.75, 137.74 APE8-dihe-in -78.53, 58.82 APE8-rot-na 30.41 APE67-dihe-in -71.12, -10.64 -57.9, -28.42 APE12-dist-na 14.791 APE11-dist-na 15.3736 APE10-dist-na 10.2941 APE9-dist-out 8.143 C1156Y None None XRAY 1.6 0.216 0.258 A 327.0 293.0 17 30 24 6 [[1116, 1385]] 1.0 5a9u Homo sapiens TYR_ALK_HUMAN TYR 1.9e-90 308.6 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 5AACA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 6.0491 14.9478 ABAminus -115.19, -31.77 -111.83, 134.22 -128.43, 30.25 290.07, 81.16 -65.53, -32.88 in-out in 8.2704 Saltbr-out 4.6082 HRD-in -73.86, -46.4 82.42, -9.17 out-out-out SNCooo out-out ActLoopNT-out 6.9248 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.47, -8.93 APE9-dihe-in -64.75, 135.46 APE8-dihe-in -76.69, 59.35 APE8-rot-na 30.37 APE67-dihe-in -71.48, -11.11 -59.44, -28.8 APE12-dist-na 14.7445 APE11-dist-na 15.3235 APE10-dist-na 10.293 APE9-dist-out 8.1919 C1156Y None None XRAY 1.7 0.208 0.232 A 327.0 293.0 17 30 24 6 [[1116, 1385]] 1.0 5aac Homo sapiens TYR_ALK_HUMAN TYR 1.9e-90 308.6 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 7BTTA Q9UM73 1093 1401 1620.0 F8R:1501 Type1 Inactive DFGin 6.1564 14.7855 ABAminus -122.03, -17.95 -119.49, 138.11 -134.22, 32.1 293.32, 88.16 -75.16, -36.17 in-in in 7.5925 Saltbr-in 2.8567 HRD-in -69.97, -43.61 74.45, -5.72 in-out-out SNCioo out-out ActLoopNT-out 7.0265 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.06, -5.75 APE9-dihe-in -67.85, 139.87 APE8-dihe-in -78.72, 64.66 APE8-rot-na 32.81 APE67-dihe-in -71.63, -7.08 -50.37, -43.62 APE12-dist-na 14.5626 APE11-dist-na 14.9078 APE10-dist-na 9.8213 APE9-dist-out 8.0875 None None None XRAY 1.86 0.188 0.209 A 320.0 304.0 5 30 30 0 [[1116, 1385]] 1.0 7btt Homo sapiens TYR_ALK_HUMAN TYR 3.9e-90 307.6 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4FOBA Q9UM73 1093 1402 1620.0 0US:1501 Type1 Inactive DFGin 6.2031 14.6081 ABAminus -121.93, -5.87 -135.31, 135.62 -128.54, 34.16 296.11, 87.18 -69.77, -38.85 in-in in 7.8612 Saltbr-in 2.6092 HRD-in -75.01, -47.81 80.74, -11.97 in-out-out SNCioo out-out ActLoopNT-out 6.9633 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -99.67, -8.45 APE9-dihe-in -60.62, 141.15 APE8-dihe-in -80.22, 63.12 APE8-rot-na 30.66 APE67-dihe-in -69.42, -9.11 -51.4, -43.54 APE12-dist-na 14.3459 APE11-dist-na 14.7246 APE10-dist-na 9.6458 APE9-dist-in 7.854 C1097S None None XRAY 1.9 0.203 0.255 A 353.0 295.0 15 30 24 6 [[1116, 1385]] 1.0 4fob Homo sapiens TYR_ALK_HUMAN TYR 1.8e-90 308.8 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4FOCA Q9UM73 1093 1402 1620.0 0UU:1501 Type1 Inactive DFGin 6.3245 14.5687 ABAminus -123.54, -7.23 -132.63, 134.75 -129.46, 36.57 293.68, 84.81 -70.2, -37.62 in-in in 7.7863 Saltbr-in 3.1014 HRD-in -69.96, -48.47 78.5, -3.5 in-out-out SNCioo out-out ActLoopNT-out 6.9878 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.01, -12.7 APE9-dihe-in -61.61, 144.79 APE8-dihe-in -84.7, 68.48 APE8-rot-na 34.22 APE67-dihe-in -73.32, -8.77 -52.28, -39.37 APE12-dist-na 12.056 APE11-dist-na 15.0289 APE10-dist-na 9.9167 APE9-dist-in 7.7646 C1097S None None XRAY 1.7 0.191 0.225 A 353.0 296.0 14 30 22 8 [[1116, 1385]] 1.0 4foc Homo sapiens TYR_ALK_HUMAN TYR 1.8e-90 308.8 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4Z55A Q9UM73 1093 1399 1620.0 4LO:1503 Type1 Inactive DFGin 6.2529 14.6352 ABAminus -123.6, 13.8 -145.92, 137.93 -133.07, 27.38 295.45, 90.97 -57.61, -49.96 in-in in 7.4562 Saltbr-in 2.7841 HRD-in -65.39, -47.79 76.59, -11.13 in-out-out SNCioo out-out ActLoopNT-out 6.8722 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.75, -10.47 APE9-dihe-in -67.58, 140.18 APE8-dihe-in -79.19, 59.38 APE8-rot-na 31.88 APE67-dihe-in -66.53, -10.05 -40.3, -48.22 APE12-dist-na 14.8771 APE11-dist-na 15.1593 APE10-dist-na 10.0854 APE9-dist-out 8.0721 S1281G None None XRAY 1.55 0.185 0.208 A 339.0 294.0 13 30 29 1 [[1116, 1385]] 1.0 4z55 Homo sapiens TYR_ALK_HUMAN TYR 4.7e-90 307.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 3LCSA Q9UM73 1096 1399 1620.0 STU:1 Type1 Inactive DFGin 6.3299 14.9123 ABAminus -115.64, -37.74 -102.74, 114.2 -112.42, 20.01 289.12, 86.66 -56.01, -38.26 in-in in 7.78 Saltbr-in 2.6618 HRD-in -69.52, -44.32 78.89, -12.54 in-out-out SNCioo out-out ActLoopNT-out 6.7937 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.07, -13.05 APE9-dihe-in -64.04, 139.47 APE8-dihe-in -80.51, 60.39 APE8-rot-na 31.54 APE67-dihe-in -67.01, -14.6 -60.37, -27.86 APE12-dist-na 15.3078 APE11-dist-na 15.5689 APE10-dist-na 10.5385 APE9-dist-out 8.2956 S1281G None None XRAY 1.95 0.196 0.229 A 344.0 304.0 0 30 30 0 [[1116, 1385]] 1.0 3lcs Homo sapiens TYR_ALK_HUMAN TYR 5e-90 307.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4MKCA Q9UM73 1093 1401 1620.0 4MK:1503 Type1 Inactive DFGin 6.1419 14.7875 ABAminus -119.13, 7.31 -142.69, 137.29 -134.51, 29.61 298.97, 84.4 -59.55, -42.66 in-in in 7.6556 Saltbr-in 2.8638 HRD-in -66.46, -45.49 70.41, -4.89 in-out-out SNCioo out-out ActLoopNT-out 6.8961 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.61, -14.66 APE9-dihe-in -63.04, 142.03 APE8-dihe-in -82.73, 64.43 APE8-rot-na 33.65 APE67-dihe-in -65.02, -10.82 -49.18, -45.64 APE12-dist-na 14.9176 APE11-dist-na 15.2507 APE10-dist-na 10.2048 APE9-dist-out 8.1176 S1281G None None XRAY 2.01 0.173 0.218 A 367.0 303.0 6 30 30 0 [[1116, 1385]] 1.0 4mkc Homo sapiens TYR_ALK_HUMAN TYR 6.2e-90 307.0 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 9GBEA Q9UM73 1086 1401 1620.0 A1IJ8:1501 Type1 Inactive DFGin 6.2263 14.8347 ABAminus -118.03, -13.57 -139.47, 137.54 -132.04, 28.84 289.39, 90.38 -67.89, -35.38 in-in in 7.8497 Saltbr-in 2.7097 HRD-in -70.68, -49.03 81.56, -8.45 in-out-out SNCioo out-out ActLoopNT-out 6.9133 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.96, -12.0 APE9-dihe-in -66.08, 139.0 APE8-dihe-in -79.17, 64.92 APE8-rot-na 34.36 APE67-dihe-in -67.16, -14.31 -60.07, -32.34 APE12-dist-na 14.1672 APE11-dist-na 15.0287 APE10-dist-na 9.8915 APE9-dist-out 8.0702 L1196M,G1202R None None XRAY 1.58 0.186 0.224 A 344.0 304.0 12 30 24 6 [[1116, 1385]] 1.0 9gbe Homo sapiens TYR_ALK_HUMAN TYR 3.3e-89 304.6 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4CNHB Q9UM73 1093 1401 1620.0 3U9:2401,3U9:2402 Type1,Allosteric Inactive DFGin 4.3394 12.3272 ABAminus -115.59, -14.06 -164.87, 163.73 -86.41, -10.43 302.46, 115.44 53.37, -130.64 in-in in 8.0724 Saltbr-in 2.6288 HRD-in -84.33, -49.79 83.6, -11.29 in-out-out SNCioo out-out ActLoopNT-out 8.5492 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -91.6, -17.34 APE9-dihe-in -73.51, 138.4 APE8-dihe-in -77.48, 68.43 APE8-rot-na 27.84 APE67-dihe-in -66.22, -13.37 -69.94, -19.9 APE12-dist-na 12.7837 APE11-dist-na 13.4643 APE10-dist-na 8.3849 APE9-dist-out 8.684 None None None XRAY 1.9 0.206 0.25 B 327.0 294.0 15 30 25 5 [[1116, 1385]] 1.0 4cnh Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4JOAA Q9UM73 1107 1398 1620.0 3DK:1501 Type1.5_Front Inactive DFGin 5.6505 15.1801 ABAminus -99.28, -25.44 -116.97, 136.23 -132.09, 28.46 289.09, 82.31 -66.18, -40.48 in-out in 8.5317 Saltbr-out 7.3232 HRD-in -79.35, -45.13 67.79, 9.59 out-out-out SNCooo out-out ActLoopNT-out 6.6325 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -75.97, -11.03 APE9-dihe-in -75.81, 135.85 APE8-dihe-in -79.69, 75.84 APE8-rot-na 32.08 APE67-dihe-in -70.53, -20.07 -69.09, -33.02 APE12-dist-na 999.0 APE11-dist-na 15.0993 APE10-dist-na 10.2802 APE9-dist-out 8.0984 S1281G None None XRAY 2.7 0.253 0.29 A 344.0 251.0 41 30 21 9 [[1116, 1385]] 1.0 4joa Homo sapiens TYR_ALK_HUMAN TYR 5e-90 307.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 2YJRA Q9UM73 1101 1402 1620.0 No_ligand No_ligand Inactive DFGin 6.3091 14.7033 None -109.22, -156.6 -24.57, 131.48 -106.45, 12.37 294.91, 66.22 -54.96, -56.35 in-in in 7.9428 Saltbr-in 3.1237 HRD-in -78.17, -44.51 78.03, -12.49 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -91.23, -22.26 APE9-dihe-in -61.19, 130.79 APE8-dihe-in -74.37, 65.56 APE8-rot-na 28.22 APE67-dihe-in -67.2, -14.23 -60.39, -32.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8552 F1174L None None XRAY 1.9 0.221 0.281 A 342.0 281.0 21 30 16 14 [[1116, 1385]] 1.0 2yjr Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.2 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 6EDLA Q9UM73 1093 1399 1620.0 J4M:1500 Type1 Inactive DFGin 5.7419 13.9986 None -126.77, 7.53 -146.28, 139.77 -129.2, 999.0 286.43, 88.97 999.0, 999.0 in-in in 8.043 Saltbr-in 3.2026 HRD-in -75.33, -45.54 75.3, -3.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -90.79, -15.28 APE9-dihe-in -62.49, 138.06 APE8-dihe-in -76.58, 62.31 APE8-rot-na 33.87 APE67-dihe-in -71.34, -10.1 -42.44, -41.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1154 None None None XRAY 2.799 0.231 0.282 A 322.0 282.0 25 30 14 16 [[1116, 1385]] 1.0 6edl Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 5IMXA Q9UM73 1109 1400 1620.0 CZ4:1501 Type1 Inactive DFGin 5.0344 14.4493 None -109.53, -14.09 -148.27, 147.07 -105.7, 146.52 283.91, 86.87 -67.35, -107.72 in-in in 8.0283 Saltbr-in 2.5042 HRD-in -65.65, -55.77 80.57, -2.35 in-out-out SNCioo out-out ActLoopNT-out 7.5579 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -82.05, -3.8 APE9-dihe-in -82.72, 146.31 APE8-dihe-in -87.12, 68.37 APE8-rot-na 16.28 APE67-dihe-in -69.01, -16.06 -50.43, -36.09 APE12-dist-na 10.9042 APE11-dist-na 15.5625 APE10-dist-na 10.6323 APE9-dist-in 7.972 None None None XRAY 2.12 0.213 0.259 A 327.0 266.0 26 30 20 10 [[1116, 1385]] 1.0 5imx Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4DCEA Q9UM73 1093 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.6296 13.8228 None -137.27, 16.47 -161.52, 152.14 -94.73, 164.26 291.72, 122.64 -76.17, 999.0 in-in in 8.4822 Saltbr-in 2.8829 HRD-in -75.4, -48.78 85.77, -10.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.83, -20.84 APE9-dihe-in -55.51, 136.7 APE8-dihe-in -77.28, 70.08 APE8-rot-na 28.6 APE67-dihe-in -68.31, -8.92 -56.77, -41.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9739 C1097S None None XRAY 2.03 0.211 0.256 A 333.0 288.0 22 30 16 14 [[1116, 1385]] 1.0 4dce Homo sapiens TYR_ALK_HUMAN TYR 1.5e-90 309.0 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4DCEB Q9UM73 1094 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.7474 13.6282 None -141.04, 18.73 -165.26, 150.02 -96.5, 167.37 286.77, 120.17 -70.38, 999.0 in-in in 8.5634 Saltbr-in 2.9896 HRD-in -72.56, -48.26 83.87, -14.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.41, -12.56 APE9-dihe-in -59.98, 136.0 APE8-dihe-in -80.48, 64.18 APE8-rot-na 31.8 APE67-dihe-in -66.1, -14.3 -52.07, -41.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.7127 C1097S None None XRAY 2.03 0.211 0.256 B 333.0 284.0 25 30 15 15 [[1116, 1385]] 1.0 4dce Homo sapiens TYR_ALK_HUMAN TYR 1.5e-90 309.0 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 5IUGA Q9UM73 1093 1404 1620.0 729:1501 Type2 Inactive DFGout 14.1533 9.9993 BBAminus -131.11, -160.99 -160.87, 113.54 -82.67, -13.49 278.51, 100.05 82.21, 14.97 in-in in 7.6694 Saltbr-in 3.0741 HRD-in -68.79, -47.96 74.11, -0.87 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.37, -10.99 APE9-dihe-in -66.27, 131.08 APE8-dihe-in -74.93, 62.41 APE8-rot-na 32.11 APE67-dihe-in -72.28, -10.91 -51.72, -32.16 APE12-dist-na 14.9994 APE11-dist-na 12.8171 APE10-dist-na 7.8996 APE9-dist-out 8.4198 C1097S None None XRAY 1.93 0.184 0.211 A 327.0 285.0 27 30 18 12 [[1116, 1385]] 1.0 5iug Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 5IUHA Q9UM73 1093 1404 1620.0 34Y:1501 Type2 Inactive DFGout 14.2321 10.118 BBAminus -138.56, -161.58 -159.14, 110.88 -77.24, -9.47 279.89, 100.17 78.06, 14.37 in-in in 7.6196 Saltbr-in 2.9882 HRD-in -72.63, -47.58 76.22, -3.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -97.17, -17.0 APE9-dihe-in -66.13, 131.14 APE8-dihe-in -77.12, 65.41 APE8-rot-na 31.95 APE67-dihe-in -67.53, -10.9 -52.9, -35.57 APE12-dist-na 14.94 APE11-dist-na 12.9611 APE10-dist-na 8.2239 APE9-dist-out 8.5443 C1097S None None XRAY 2.1 0.183 0.221 A 327.0 285.0 27 30 17 13 [[1116, 1385]] 1.0 5iuh Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK ALK_HUMAN 4FNYA Q9UM73 1103 1404 1620.0 I3K:1501 Type2 Inactive DFGout 14.1839 10.0885 None -127.21, -165.1 -161.64, 122.7 -96.04, 999.0 291.91, 90.85 999.0, 999.0 in-in in 7.8988 Saltbr-in 2.5278 HRD-in -68.56, -48.94 76.07, 1.7 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.3, -24.9 APE9-dihe-in -67.06, 137.93 APE8-dihe-in -72.43, 66.19 APE8-rot-na 27.5 APE67-dihe-in -66.24, -16.71 -48.34, -39.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2142 C1097S,R1275Q None None XRAY 2.45 0.196 0.252 A 327.0 273.0 29 30 14 16 [[1116, 1385]] 1.0 4fny Homo sapiens TYR_ALK_HUMAN TYR 3.6e-90 307.7 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor

TYR_ALK (ALK tyrosine kinase receptor)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name