TYR_ALK (ALK tyrosine kinase receptor)

Total number of chains: 68
Active chains: 2
Family: TYR
Uniprot: ALK_HUMAN
Kinase Domain Residues: 1116 - 1385
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 58 85.3% 3LCSA
DFGin None 5 7.4% 2YJRA
DFGin BLAminus 2 2.9% AF-Q9UM73-K1A
DFGout BBAminus 2 2.9% 5IUGA
DFGout None 1 1.5% 4FNYA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q9UM73-K1A 1108 1393 1620.0 No_ligand No_ligand Active DFGin 5.946 14.375 BLAminus -128.36, -171.81 51.94, 77.78 -92.22, 15.36 286.64, 85.92 -56.6, -33.49 in-in in 7.977 Saltbr-in 2.631 HRD-in -84.5, -39.96 65.84, -13.69 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.67, 132.62 APE9-dihe-in -132.53, 142.2 APE8-dihe-in -77.98, 67.6 APE8-rot-na 34.24 APE67-dihe-in -67.7, -9.18 -47.25, -44.33 APE12-dist-na 15.19 APE11-dist-na 9.617 APE10-dist-na 10.461 APE9-dist-in 7.204 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[1116, 1385]] 1.0 AF-Q9UM73-K1 TYR_ALK_HUMAN TYR 8.6e-91 309.7 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
AF-Q9UM73-K3A 1108 1393 1620.0 No_ligand No_ligand Active DFGin 6.052 13.607 BLAminus -131.74, -170.01 51.86, 66.91 -83.62, 16.51 291.43, 91.58 -58.46, -31.87 in-in in 8.079 Saltbr-in 2.687 HRD-in -85.25, -38.15 64.37, 4.14 in-in-in SNCiii in-in ActLoopNT-in 2.867 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.58, 98.52 APE9-dihe-in -103.22, 145.61 APE8-dihe-in -72.6, 70.7 APE8-rot-na 33.25 APE67-dihe-in -77.31, -3.9 -52.0, -31.13 APE12-dist-na 16.467 APE11-dist-na 10.435 APE10-dist-na 11.254 APE9-dist-in 7.285 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[1116, 1385]] 1.0 AF-Q9UM73-K3 TYR_ALK_HUMAN TYR 8.6e-91 309.7 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
3LCTA 1093 1400 1620.0 ADP:1412 ATPlike Inactive DFGin 6.266 15.193 ABAminus -127.22, 10.26 -136.37, 129.73 -130.23, 18.7 291.41, 88.16 -49.74, -46.74 in-none in 8.1 Saltbr-none 999.0 HRD-in -78.72, -45.58 81.21, -3.39 none-out-out SNCnoo out-out ActLoopNT-out 6.886 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -94.62, -10.42 APE9-dihe-in -67.88, 140.77 APE8-dihe-in -81.63, 62.42 APE8-rot-na 34.08 APE67-dihe-in -66.16, -16.53 -61.79, -27.56 APE12-dist-na 14.739 APE11-dist-na 15.112 APE10-dist-na 9.981 APE9-dist-out 8.031 S1281G None None XRAY 2.1 0.207 0.255 A 344 308 0 0 0 0 [[1116, 1385]] 1.0 3lct TYR_ALK_HUMAN TYR 5e-90 307.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4TT7A 1095 1400 1620.0 COM:61501,COM:61502 Allosteric,Allosteric Inactive DFGin 6.331 15.104 ABAminus -129.34, 13.94 -143.37, 136.26 -133.45, 29.15 287.86, 86.47 -61.1, -46.06 in-in in 8.276 Saltbr-in 2.899 HRD-in -65.35, -47.66 76.28, -7.96 in-out-out SNCioo out-out ActLoopNT-out 6.717 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -97.0, -10.73 APE9-dihe-in -72.98, 131.19 APE8-dihe-in -73.54, 64.64 APE8-rot-na 32.16 APE67-dihe-in -68.68, -12.97 -52.76, -40.18 APE12-dist-na 14.946 APE11-dist-na 15.258 APE10-dist-na 10.088 APE9-dist-out 8.134 None None None XRAY 2.1 0.195 0.244 A 325 290 16 0 0 2 [[1116, 1385]] 1.0 4tt7 TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
7JY4A 1096 1399 1620.0 W47:1701,W47:1702 Allosteric,Type1 Inactive DFGin 5.92 14.519 ABAminus -113.43, -9.3 -142.4, 138.16 -131.48, 29.53 294.61, 83.59 -63.18, -27.52 in-out in 7.579 Saltbr-out 4.289 HRD-in -66.41, -52.1 72.58, 14.97 out-out-out SNCooo out-out ActLoopNT-out 6.665 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.55, -8.29 APE9-dihe-in -68.93, 134.74 APE8-dihe-in -72.25, 67.62 APE8-rot-na 30.54 APE67-dihe-in -68.71, -7.15 -58.46, -37.5 APE12-dist-na 14.864 APE11-dist-na 15.637 APE10-dist-na 10.484 APE9-dist-out 8.472 None None None XRAY 2.42 0.221 0.255 A 322 290 14 0 0 7 [[1116, 1385]] 1.0 7jy4 TYR_ALK_HUMAN TYR 1.3e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
2YHVA 1093 1401 1620.0 No_ligand No_ligand Inactive DFGin 6.292 15.188 ABAminus -123.67, -1.11 -136.06, 135.4 -132.07, 27.87 288.99, 87.09 -68.12, -28.8 in-out in 8.007 Saltbr-out 4.973 HRD-in -77.85, -44.61 80.59, -11.15 out-out-out SNCooo out-out ActLoopNT-out 6.971 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.52, -6.03 APE9-dihe-in -64.98, 136.8 APE8-dihe-in -78.21, 58.76 APE8-rot-na 28.31 APE67-dihe-in -70.14, -11.55 -58.4, -31.21 APE12-dist-na 14.583 APE11-dist-na 15.003 APE10-dist-na 10.002 APE9-dist-out 8.103 L1196M None None XRAY 1.9 0.206 0.238 A 342 292 17 0 0 6 [[1116, 1385]] 1.0 2yhv TYR_ALK_HUMAN TYR 6e-91 310.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4ANLA 1094 1402 1620.0 No_ligand No_ligand Inactive DFGin 6.319 15.074 ABAminus -122.56, -44.06 -97.45, 124.8 -122.56, 30.81 292.45, 83.3 -66.54, -36.82 in-out in 8.023 Saltbr-out 4.852 HRD-in -74.81, -43.42 79.26, -10.5 out-out-out SNCooo out-out ActLoopNT-out 6.976 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.21, -6.47 APE9-dihe-in -62.46, 134.19 APE8-dihe-in -75.42, 58.77 APE8-rot-na 29.27 APE67-dihe-in -71.73, -7.68 -54.8, -34.96 APE12-dist-na 14.376 APE11-dist-na 14.79 APE10-dist-na 9.85 APE9-dist-out 8.04 G1269A None None XRAY 1.7 0.202 0.216 A 342 293 16 0 0 6 [[1116, 1385]] 1.0 4anl TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4FNWA 1084 1405 1620.0 No_ligand No_ligand Inactive DFGin 6.266 14.909 ABAminus -118.46, -25.35 -118.23, 130.17 -123.97, 30.37 289.23, 85.23 -66.19, -35.54 in-in in 7.973 Saltbr-in 3.271 HRD-in -71.6, -47.27 80.64, -6.43 in-out-out SNCioo out-out ActLoopNT-out 7.009 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.87, -11.88 APE9-dihe-in -57.72, 142.89 APE8-dihe-in -82.66, 63.25 APE8-rot-na 32.43 APE67-dihe-in -71.06, -7.27 -50.06, -41.71 APE12-dist-na 11.921 APE11-dist-na 15.101 APE10-dist-na 10.055 APE9-dist-in 7.916 C1097S,F1174L None None XRAY 1.75 0.181 0.203 A 327 304 18 0 0 8 [[1116, 1385]] 1.0 4fnw TYR_ALK_HUMAN TYR 1.1e-90 309.4 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4FNXA 1093 1404 1620.0 No_ligand No_ligand Inactive DFGin 6.056 14.83 ABAminus -115.68, -17.57 -132.37, 141.55 -132.11, 50.23 294.37, 89.4 -81.69, -11.71 in-in in 7.879 Saltbr-in 2.9 HRD-in -67.87, -45.92 63.48, 21.39 in-out-out SNCioo out-out ActLoopNT-out 8.796 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.41, -1.04 APE9-dihe-in -70.97, 126.88 APE8-dihe-in -77.01, 61.37 APE8-rot-na 28.92 APE67-dihe-in -68.85, -9.84 -51.53, -36.34 APE12-dist-na 12.798 APE11-dist-na 16.426 APE10-dist-na 11.551 APE9-dist-out 8.771 C1097S,R1275Q None None XRAY 1.7 0.196 0.23 A 327 292 20 0 0 9 [[1116, 1385]] 1.0 4fnx TYR_ALK_HUMAN TYR 3.6e-90 307.7 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
6CDTA 1093 1400 1620.0 No_ligand No_ligand Inactive DFGin 6.3 15.124 ABAminus -123.35, -15.42 -125.06, 128.52 -124.36, 30.18 290.06, 83.02 -64.75, -38.93 in-out in 7.995 Saltbr-out 4.979 HRD-in -72.97, -44.41 80.06, -9.45 out-out-out SNCooo out-out ActLoopNT-out 7.024 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -101.22, -7.31 APE9-dihe-in -65.06, 137.47 APE8-dihe-in -74.57, 60.9 APE8-rot-na 29.07 APE67-dihe-in -75.35, -6.12 -48.18, -42.21 APE12-dist-na 14.453 APE11-dist-na 14.779 APE10-dist-na 9.783 APE9-dist-in 7.861 None None None XRAY 1.8 0.196 0.226 A 327 292 16 0 0 6 [[1116, 1385]] 1.0 6cdt TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
2YJSA 1094 1402 1620.0 No_ligand No_ligand Inactive DFGin 5.933 15.066 ABAminus -121.83, -11.53 -129.45, 132.48 -129.61, 30.1 290.02, 84.24 -67.53, -32.65 in-out in 8.529 Saltbr-out 3.759 HRD-in -74.02, -46.25 80.81, -7.98 out-out-out SNCooo out-out ActLoopNT-out 6.963 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -95.71, -13.28 APE9-dihe-in -61.54, 135.1 APE8-dihe-in -77.63, 61.25 APE8-rot-na 30.06 APE67-dihe-in -69.46, -13.22 -55.44, -32.78 APE12-dist-na 14.159 APE11-dist-na 15.268 APE10-dist-na 10.268 APE9-dist-out 8.189 C1156Y None None XRAY 1.9 0.211 0.243 A 342 290 19 0 0 8 [[1116, 1385]] 1.0 2yjs TYR_ALK_HUMAN TYR 2.2e-90 308.4 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
3L9PA 1093 1400 1620.0 No_ligand No_ligand Inactive DFGin 6.219 15.156 ABAminus -126.0, -1.93 -131.15, 131.2 -131.41, 25.42 291.27, 88.64 -59.73, -44.21 in-none in 7.982 Saltbr-none 999.0 HRD-in -69.61, -44.54 77.55, -8.47 none-out-out SNCnoo out-out ActLoopNT-out 6.883 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.3, -11.47 APE9-dihe-in -69.19, 138.58 APE8-dihe-in -80.43, 62.6 APE8-rot-na 32.84 APE67-dihe-in -67.59, -13.49 -45.09, -43.43 APE12-dist-na 14.948 APE11-dist-na 15.11 APE10-dist-na 10.009 APE9-dist-in 7.904 S1281G None None XRAY 1.8 0.192 0.226 A 367 303 5 0 0 0 [[1116, 1385]] 1.0 3l9p TYR_ALK_HUMAN TYR 6.2e-90 307.0 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4ANSA 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 6.248 15.162 ABAminus -128.23, -41.44 -98.11, 120.9 -117.53, 30.59 287.81, 85.26 -66.49, -38.26 in-out in 8.265 Saltbr-out 4.892 HRD-in -72.85, -44.3 78.64, -9.03 out-out-out SNCooo out-out ActLoopNT-out 6.908 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.15, -7.92 APE9-dihe-in -66.26, 134.84 APE8-dihe-in -77.14, 60.8 APE8-rot-na 30.33 APE67-dihe-in -70.27, -10.51 -58.92, -29.59 APE12-dist-na 14.661 APE11-dist-na 14.883 APE10-dist-na 9.857 APE9-dist-out 8.039 L1196M,G1269A None None XRAY 1.85 0.201 0.231 A 342 294 16 0 0 6 [[1116, 1385]] 1.0 4ans TYR_ALK_HUMAN TYR 5.2e-91 310.5 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
2YFXA 1093 1401 1620.0 VGH:9000 Type1 Inactive DFGin 6.221 14.881 ABAminus -122.22, -28.6 -114.9, 132.72 -127.11, 33.52 293.03, 85.04 -65.89, -37.73 in-out in 7.914 Saltbr-out 4.75 HRD-in -73.95, -43.63 78.32, -9.23 out-out-out SNCooo out-out ActLoopNT-out 6.956 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.12, -9.34 APE9-dihe-in -61.51, 137.47 APE8-dihe-in -77.72, 57.54 APE8-rot-na 29.78 APE67-dihe-in -70.24, -8.94 -56.4, -32.44 APE12-dist-na 14.505 APE11-dist-na 14.933 APE10-dist-na 9.92 APE9-dist-out 8.05 L1196M None None XRAY 1.7 0.208 0.234 A 327 293 16 0 0 6 [[1116, 1385]] 1.0 2yfx TYR_ALK_HUMAN TYR 5.1e-91 310.5 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4CLJA 1094 1402 1620.0 5P8:2402 Type1 Inactive DFGin 6.203 14.805 ABAminus -125.62, -0.02 -140.07, 135.04 -130.43, 32.34 295.46, 85.14 -65.98, -39.5 in-in in 8.011 Saltbr-in 2.711 HRD-in -71.97, -45.96 80.49, -8.87 in-out-out SNCioo out-out ActLoopNT-out 6.963 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.51, -5.34 APE9-dihe-in -68.88, 140.43 APE8-dihe-in -76.17, 58.33 APE8-rot-na 29.07 APE67-dihe-in -72.79, -6.46 -47.28, -42.69 APE12-dist-na 14.558 APE11-dist-na 14.807 APE10-dist-na 9.789 APE9-dist-in 7.937 L1196M None None XRAY 1.66 0.197 0.229 A 327 296 13 0 0 6 [[1116, 1385]] 1.0 4clj TYR_ALK_HUMAN TYR 5.1e-91 310.5 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4CD0A 1094 1402 1620.0 AWJ:1500 Type1 Inactive DFGin 6.21 14.807 ABAminus -124.48, -7.47 -131.66, 141.46 -133.85, 29.84 290.85, 86.66 -65.46, -35.12 in-in in 7.711 Saltbr-in 2.745 HRD-in -77.45, -47.18 84.39, -11.38 in-out-out SNCioo out-out ActLoopNT-out 6.887 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.9, -13.71 APE9-dihe-in -68.46, 134.66 APE8-dihe-in -73.25, 65.7 APE8-rot-na 30.38 APE67-dihe-in -69.89, -9.61 -53.98, -40.39 APE12-dist-na 14.705 APE11-dist-na 14.91 APE10-dist-na 9.725 APE9-dist-in 7.976 L1196M None None XRAY 2.23 0.198 0.25 A 342 296 13 0 0 6 [[1116, 1385]] 1.0 4cd0 TYR_ALK_HUMAN TYR 6e-91 310.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4ANQA 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 6.209 14.974 ABAminus -128.3, -36.39 -101.79, 127.42 -123.56, 31.99 288.31, 85.14 -69.12, -35.87 in-out in 8.27 Saltbr-out 4.789 HRD-in -73.02, -46.15 80.91, -7.4 out-out-out SNCooo out-out ActLoopNT-out 6.947 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -98.41, -8.07 APE9-dihe-in -67.75, 134.94 APE8-dihe-in -74.89, 59.28 APE8-rot-na 29.64 APE67-dihe-in -70.46, -10.96 -58.56, -29.68 APE12-dist-na 14.724 APE11-dist-na 14.955 APE10-dist-na 9.922 APE9-dist-out 8.019 G1269A None None XRAY 1.76 0.201 0.217 A 342 294 16 0 0 6 [[1116, 1385]] 1.0 4anq TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
5AA9A 1093 1402 1620.0 5P8:2402 Type1 Inactive DFGin 6.182 14.891 ABAminus -123.86, -6.83 -134.63, 136.55 -132.06, 29.87 289.56, 85.44 -66.04, -35.64 in-out in 8.157 Saltbr-out 4.537 HRD-in -75.17, -44.12 79.72, -10.27 out-out-out SNCooo out-out ActLoopNT-out 6.848 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.37, -11.88 APE9-dihe-in -67.63, 135.25 APE8-dihe-in -76.86, 63.04 APE8-rot-na 30.41 APE67-dihe-in -70.03, -11.65 -60.61, -27.66 APE12-dist-na 14.916 APE11-dist-na 15.23 APE10-dist-na 10.096 APE9-dist-out 8.159 L1198F None None XRAY 1.93 0.201 0.237 A 327 296 14 0 0 6 [[1116, 1385]] 1.0 5aa9 TYR_ALK_HUMAN TYR 4.4e-91 310.7 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
5AAAA 1093 1401 1620.0 VGH:9000 Type1 Inactive DFGin 6.209 14.916 ABAminus -119.08, -27.29 -116.14, 136.82 -130.64, 32.52 289.46, 85.69 -67.72, -37.15 in-out in 7.969 Saltbr-out 4.67 HRD-in -74.4, -45.03 79.43, -9.27 out-out-out SNCooo out-out ActLoopNT-out 6.898 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.98, -3.96 APE9-dihe-in -73.12, 136.6 APE8-dihe-in -77.4, 61.62 APE8-rot-na 28.9 APE67-dihe-in -71.26, -10.51 -60.21, -28.6 APE12-dist-na 14.555 APE11-dist-na 14.849 APE10-dist-na 9.8 APE9-dist-out 8.03 L1198F None None XRAY 1.73 0.201 0.206 A 327 295 14 0 0 6 [[1116, 1385]] 1.0 5aaa TYR_ALK_HUMAN TYR 4.4e-91 310.7 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
5AA8A 1093 1402 1620.0 5P8:2402 Type1 Inactive DFGin 6.086 14.918 ABAminus -121.09, -8.69 -130.71, 131.76 -128.08, 33.6 288.19, 85.62 -75.96, -22.55 in-out in 8.245 Saltbr-out 4.485 HRD-in -76.73, -45.37 80.25, -8.63 out-out-out SNCooo out-out ActLoopNT-out 6.799 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.53, -15.21 APE9-dihe-in -61.78, 135.61 APE8-dihe-in -77.32, 62.22 APE8-rot-na 29.6 APE67-dihe-in -71.9, -11.44 -60.22, -27.26 APE12-dist-na 14.682 APE11-dist-na 15.552 APE10-dist-na 10.481 APE9-dist-out 8.188 C1156Y,L1198F None None XRAY 1.86 0.209 0.233 A 327 293 17 0 0 6 [[1116, 1385]] 1.0 5aa8 TYR_ALK_HUMAN TYR 5.9e-91 310.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
5AABA 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 5.962 14.941 ABAminus -122.06, -28.4 -115.22, 132.25 -127.31, 26.85 289.37, 81.1 -65.12, -33.9 in-out in 8.083 Saltbr-out 4.27 HRD-in -73.35, -48.11 83.65, -8.17 out-out-out SNCooo out-out ActLoopNT-out 6.963 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.88, -2.64 APE9-dihe-in -78.59, 133.38 APE8-dihe-in -74.05, 62.22 APE8-rot-na 30.08 APE67-dihe-in -71.71, -12.93 -64.03, -23.79 APE12-dist-na 15.1 APE11-dist-na 15.205 APE10-dist-na 10.087 APE9-dist-out 8.086 C1156Y,L1198F None None XRAY 2.2 0.211 0.246 A 327 294 16 0 0 6 [[1116, 1385]] 1.0 5aab TYR_ALK_HUMAN TYR 5.9e-91 310.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
6MX8A 1094 1400 1620.0 6GY:1500 Type1 Inactive DFGin 6.142 14.662 ABAminus -114.12, -38.77 -118.14, 138.18 -129.19, 26.62 289.5, 87.05 -61.73, -41.9 in-in in 7.786 Saltbr-in 3.234 HRD-in -72.93, -50.14 84.31, -4.9 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.89, -3.2 APE9-dihe-in -73.94, 138.53 APE8-dihe-in -85.7, 68.86 APE8-rot-na 37.09 APE67-dihe-in -74.13, -8.15 -48.67, -39.52 APE12-dist-na 14.244 APE11-dist-na 15.184 APE10-dist-na 10.084 APE9-dist-out 8.168 None None None XRAY 1.96 0.185 0.227 A 307 282 25 0 0 13 [[1116, 1385]] 1.0 6mx8 TYR_ALK_HUMAN TYR 1.1e-90 309.4 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
2XB7A 1095 1401 1620.0 GUI:1501 Type1 Inactive DFGin 5.731 14.599 ABAminus -132.42, -0.18 -141.44, 142.16 -131.03, 43.77 292.96, 89.17 -72.28, -38.54 in-in in 7.532 Saltbr-in 3.184 HRD-in -87.04, -46.67 85.76, -13.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.32, -3.08 APE9-dihe-in -73.74, 136.06 APE8-dihe-in -78.24, 56.9 APE8-rot-na 30.55 APE67-dihe-in -70.57, -6.09 -40.69, -40.8 APE12-dist-na 999.0 APE11-dist-na 15.273 APE10-dist-na 10.496 APE9-dist-out 8.336 None None None XRAY 2.5 0.195 0.243 A 315 286 21 0 0 14 [[1116, 1385]] 1.0 2xb7 TYR_ALK_HUMAN TYR 1.2e-90 309.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
2XBAA 1095 1402 1620.0 571:1501 Type1 Inactive DFGin 6.085 14.874 ABAminus -122.73, -16.28 -123.08, 138.16 -132.25, 31.45 293.73, 90.75 -70.57, -36.09 in-in in 7.995 Saltbr-in 2.825 HRD-in -75.43, -45.29 77.63, -4.66 in-out-out SNCioo out-out ActLoopNT-out 6.994 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.39, 0.87 APE9-dihe-in -70.63, 140.95 APE8-dihe-in -81.29, 62.03 APE8-rot-na 33.35 APE67-dihe-in -68.85, -9.81 -51.55, -41.48 APE12-dist-na 999.0 APE11-dist-na 14.9 APE10-dist-na 9.915 APE9-dist-out 8.105 None None None XRAY 1.95 0.195 0.229 A 315 284 24 0 0 10 [[1116, 1385]] 1.0 2xba TYR_ALK_HUMAN TYR 1.2e-90 309.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
5FTOA 1094 1401 1620.0 YMX:62402 Type1 Inactive DFGin 6.614 15.103 ABAminus -123.37, 0.05 -137.72, 139.58 -135.41, 24.82 289.1, 90.09 -60.28, -46.38 in-in in 7.802 Saltbr-in 2.713 HRD-in -72.55, -46.15 82.21, -13.13 in-out-out SNCioo out-out ActLoopNT-out 7.089 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -91.32, -8.05 APE9-dihe-in -57.49, 136.7 APE8-dihe-in -78.81, 60.16 APE8-rot-na 28.18 APE67-dihe-in -67.52, -8.47 -48.73, -45.52 APE12-dist-na 11.517 APE11-dist-na 14.857 APE10-dist-na 9.821 APE9-dist-in 7.967 None None None XRAY 2.22 0.199 0.257 A 315 297 11 0 0 7 [[1116, 1385]] 1.0 5fto TYR_ALK_HUMAN TYR 1.2e-90 309.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
5FTQA 1094 1401 1620.0 U4W:62402 Type1 Inactive DFGin 6.538 14.825 ABAminus -118.64, -8.41 -138.53, 135.08 -126.73, 26.7 295.74, 85.6 -58.63, -49.74 in-in in 7.605 Saltbr-in 2.579 HRD-in -70.78, -46.77 80.03, 2.04 in-out-out SNCioo out-out ActLoopNT-out 6.929 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.78, -4.85 APE9-dihe-in -67.75, 140.01 APE8-dihe-in -77.42, 62.81 APE8-rot-na 24.56 APE67-dihe-in -73.5, -8.73 -54.41, -36.36 APE12-dist-na 12.688 APE11-dist-na 14.956 APE10-dist-na 9.921 APE9-dist-in 7.795 None None None XRAY 1.7 0.175 0.22 A 315 292 16 0 0 8 [[1116, 1385]] 1.0 5ftq TYR_ALK_HUMAN TYR 1.2e-90 309.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
8ARJA 1103 1399 1620.0 NRR:1501 Type1 Inactive DFGin 6.119 14.524 ABAminus -117.07, -37.76 -110.06, 107.52 -111.08, 38.44 282.92, 90.71 -87.79, -43.75 in-in in 7.862 Saltbr-in 2.577 HRD-in -71.95, -46.72 76.96, -5.2 in-out-out SNCioo out-out ActLoopNT-out 6.553 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -98.2, -2.7 APE9-dihe-in -71.32, 134.53 APE8-dihe-in -74.4, 64.1 APE8-rot-na 36.74 APE67-dihe-in -65.93, -15.67 -63.14, -27.35 APE12-dist-na 15.602 APE11-dist-na 15.795 APE10-dist-na 10.57 APE9-dist-out 8.4 None None None XRAY 1.645 0.198 0.229 A 321 275 22 0 0 8 [[1116, 1385]] 1.0 8arj TYR_ALK_HUMAN TYR 1.3e-90 309.2 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
6E0RA 1099 1399 1620.0 HKJ:1500 Type1 Inactive DFGin 5.99 14.13 ABAminus -126.54, 6.88 -146.63, 139.75 -129.52, 23.79 286.55, 86.22 -54.44, -45.81 in-out in 8.291 Saltbr-out 4.491 HRD-in -74.7, -43.96 75.16, -3.83 out-out-none SNCoon out-none ActLoopNT-out 6.491 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -139.14 APE9-dihe-in -62.89, 135.23 APE8-dihe-in -79.57, 61.66 APE8-rot-na 34.01 APE67-dihe-in -70.37, -9.48 -43.47, -41.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.883 APE9-dist-in 7.808 None None None XRAY 2.303 0.241 0.296 A 322 279 22 0 0 11 [[1116, 1385]] 1.0 6e0r TYR_ALK_HUMAN TYR 1.3e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
6EBWA 1096 1399 1620.0 J3Y:1500 Type1 Inactive DFGin 6.332 14.771 ABAminus -124.53, 13.61 -158.52, 147.01 -134.91, 49.92 284.01, 90.06 -74.0, -48.2 in-out in 7.725 Saltbr-out 5.135 HRD-in -83.27, -44.43 72.92, 3.22 out-out-none SNCoon out-none ActLoopNT-out 7.088 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 149.36 APE8-dihe-in -68.97, 75.32 APE8-rot-na 28.29 APE67-dihe-in -64.76, -14.09 -59.15, -42.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.811 None None None XRAY 2.455 0.246 0.286 A 322 277 24 0 0 14 [[1116, 1385]] 1.0 6ebw TYR_ALK_HUMAN TYR 1.3e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
7JYRA 1095 1399 1620.0 VTA:1601 Type1 Inactive DFGin 6.037 14.647 ABAminus -117.25, -3.0 -143.43, 138.22 -132.95, 32.31 290.25, 83.3 -65.6, -36.91 in-out in 7.918 Saltbr-out 4.757 HRD-in -74.08, -42.05 82.36, -13.99 out-out-out SNCooo out-out ActLoopNT-out 6.909 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.47, -3.99 APE9-dihe-in -74.12, 138.94 APE8-dihe-in -75.24, 67.71 APE8-rot-na 31.71 APE67-dihe-in -73.48, -9.59 -58.72, -34.79 APE12-dist-na 15.178 APE11-dist-na 15.655 APE10-dist-na 10.5 APE9-dist-out 8.454 None None None XRAY 2.32 0.216 0.247 A 322 287 18 0 0 7 [[1116, 1385]] 1.0 7jyr TYR_ALK_HUMAN TYR 1.3e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
7JYSA 1095 1399 1620.0 VTD:1601 Type1 Inactive DFGin 5.847 14.421 ABAminus -117.17, -14.0 -132.7, 135.12 -128.93, 36.18 292.83, 86.2 -69.53, -37.99 in-in in 7.962 Saltbr-in 2.539 HRD-in -70.79, -47.81 83.57, -7.04 in-out-out SNCioo out-out ActLoopNT-out 6.954 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -114.43, -7.14 APE9-dihe-in -64.31, 136.8 APE8-dihe-in -71.91, 66.98 APE8-rot-na 26.54 APE67-dihe-in -68.83, -10.73 -59.12, -37.36 APE12-dist-na 15.097 APE11-dist-na 15.496 APE10-dist-na 10.354 APE9-dist-out 8.19 None None None XRAY 2.22 0.216 0.253 A 322 281 24 0 0 7 [[1116, 1385]] 1.0 7jys TYR_ALK_HUMAN TYR 1.3e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
7JYTA 1095 1399 1620.0 VRM:1502 Type1 Inactive DFGin 5.977 14.46 ABAminus -124.69, -2.73 -143.22, 137.8 -131.88, 32.76 291.21, 85.91 -67.73, -37.01 in-out in 7.924 Saltbr-out 5.327 HRD-in -79.43, -44.52 77.34, -3.4 out-out-out SNCooo out-out ActLoopNT-out 6.823 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -112.03, -10.17 APE9-dihe-in -61.0, 135.32 APE8-dihe-in -73.73, 64.74 APE8-rot-na 29.73 APE67-dihe-in -69.91, -11.24 -57.53, -36.41 APE12-dist-na 15.041 APE11-dist-na 15.528 APE10-dist-na 10.358 APE9-dist-out 8.143 None None None XRAY 2.0 0.209 0.224 A 322 281 24 0 0 7 [[1116, 1385]] 1.0 7jyt TYR_ALK_HUMAN TYR 1.3e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
2XP2A 1093 1401 1620.0 VGH:9000 Type1 Inactive DFGin 6.01 14.853 ABAminus -116.89, -30.31 -113.6, 135.35 -129.42, 33.32 290.86, 85.52 -68.93, -36.66 in-out in 8.312 Saltbr-out 4.843 HRD-in -70.6, -46.14 82.26, -7.39 out-out-out SNCooo out-out ActLoopNT-out 6.785 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -14.78 APE9-dihe-in -71.8, 131.97 APE8-dihe-in -75.49, 62.54 APE8-rot-na 30.87 APE67-dihe-in -72.66, -13.49 -62.38, -23.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.148 APE9-dist-out 8.257 None None None XRAY 1.9 0.207 0.252 A 327 289 20 0 0 9 [[1116, 1385]] 1.0 2xp2 TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4CCBA 1093 1401 1620.0 OFG:2401 Type1 Inactive DFGin 6.05 14.768 ABAminus -119.22, -9.24 -133.44, 139.2 -130.65, 36.27 292.81, 84.36 -70.77, -32.92 in-in in 7.849 Saltbr-in 2.919 HRD-in -75.15, -47.62 82.69, -9.54 in-out-none SNCion out-none ActLoopNT-out 6.896 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -19.77 APE9-dihe-in -65.32, 136.43 APE8-dihe-in -75.25, 61.07 APE8-rot-na 30.01 APE67-dihe-in -69.24, -12.29 -57.16, -31.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.95 APE9-dist-in 7.908 None None None XRAY 2.03 0.202 0.235 A 327 291 18 0 0 9 [[1116, 1385]] 1.0 4ccb TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4CCUA 1093 1402 1620.0 AWF:1500 Type1 Inactive DFGin 6.02 14.623 ABAminus -118.73, -9.8 -132.17, 139.04 -133.56, 37.48 295.42, 86.35 -74.53, -27.89 in-out in 8.277 Saltbr-out 4.689 HRD-in -77.94, -47.73 82.62, -10.67 out-out-out SNCooo out-out ActLoopNT-out 6.803 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.98, -27.23 APE9-dihe-in -56.62, 135.11 APE8-dihe-in -75.38, 65.75 APE8-rot-na 29.29 APE67-dihe-in -70.29, -14.23 -60.1, -29.45 APE12-dist-na 14.525 APE11-dist-na 15.17 APE10-dist-na 10.028 APE9-dist-in 7.796 None None None XRAY 2.0 0.202 0.233 A 327 293 17 0 0 6 [[1116, 1385]] 1.0 4ccu TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4CLIA 1093 1401 1620.0 5P8:2401 Type1 Inactive DFGin 6.104 14.664 ABAminus -126.26, -5.06 -135.36, 136.5 -131.98, 39.01 293.42, 86.05 -79.91, -26.98 in-out in 8.304 Saltbr-out 4.519 HRD-in -75.26, -46.3 81.47, -9.07 out-out-out SNCooo out-out ActLoopNT-out 6.844 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.34, -12.93 APE9-dihe-in -62.11, 137.41 APE8-dihe-in -77.3, 59.87 APE8-rot-na 29.14 APE67-dihe-in -74.79, -11.71 -58.14, -27.0 APE12-dist-na 14.664 APE11-dist-na 14.982 APE10-dist-na 10.003 APE9-dist-in 7.829 None None None XRAY 2.05 0.199 0.245 A 327 295 14 0 0 6 [[1116, 1385]] 1.0 4cli TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4CMOA 1093 1402 1620.0 YPW:2402 Type1 Inactive DFGin 6.179 14.729 ABAminus -120.95, -9.17 -132.13, 138.79 -131.64, 32.19 292.59, 86.4 -67.48, -36.83 in-out in 8.108 Saltbr-out 5.099 HRD-in -74.69, -45.72 80.53, -9.82 out-out-out SNCooo out-out ActLoopNT-out 6.894 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.18, -16.6 APE9-dihe-in -61.82, 137.9 APE8-dihe-in -75.79, 58.08 APE8-rot-na 29.65 APE67-dihe-in -70.92, -9.19 -55.73, -32.13 APE12-dist-na 14.61 APE11-dist-na 14.902 APE10-dist-na 9.821 APE9-dist-in 7.831 None None None XRAY 2.05 0.199 0.245 A 327 296 14 0 0 6 [[1116, 1385]] 1.0 4cmo TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4CMTA 1093 1401 1620.0 GWH:2401 Type1 Inactive DFGin 6.212 14.83 ABAminus -123.22, -5.39 -133.47, 138.97 -132.82, 32.21 291.71, 85.66 -66.83, -37.56 in-in in 7.927 Saltbr-in 2.622 HRD-in -73.35, -43.01 78.17, -7.26 in-out-none SNCion out-none ActLoopNT-out 6.913 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 3.2 APE9-dihe-in -71.77, 138.91 APE8-dihe-in -76.34, 59.3 APE8-rot-na 30.92 APE67-dihe-in -69.85, -8.04 -57.32, -34.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.793 APE9-dist-in 7.876 None None None XRAY 1.73 0.214 0.248 A 327 288 21 0 0 9 [[1116, 1385]] 1.0 4cmt TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4CMUA 1093 1401 1620.0 IV7:2401 Type1 Inactive DFGin 6.225 14.848 ABAminus -119.02, -15.67 -129.52, 137.46 -129.87, 35.57 292.32, 83.85 -72.08, -34.25 in-out in 8.268 Saltbr-out 5.052 HRD-in -73.08, -46.65 81.42, -8.55 out-out-out SNCooo out-out ActLoopNT-out 6.944 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -98.74, -12.22 APE9-dihe-in -65.64, 137.39 APE8-dihe-in -75.72, 59.54 APE8-rot-na 29.91 APE67-dihe-in -71.19, -9.41 -57.38, -31.15 APE12-dist-na 14.669 APE11-dist-na 14.871 APE10-dist-na 9.865 APE9-dist-in 7.894 None None None XRAY 1.8 0.206 0.227 A 327 295 14 0 0 6 [[1116, 1385]] 1.0 4cmu TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4CNHA 1094 1402 1620.0 3U9:2402 Type1 Inactive DFGin 6.328 15.046 ABAminus -121.41, -13.5 -134.76, 134.27 -127.13, 24.83 291.86, 80.94 -58.37, -37.06 in-out in 7.905 Saltbr-out 4.916 HRD-in -72.36, -47.54 81.36, -5.81 out-out-none SNCoon out-none ActLoopNT-out 7.025 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 36.87 APE9-dihe-in -64.44, 124.84 APE8-dihe-in -71.68, 78.76 APE8-rot-na 25.36 APE67-dihe-in -71.29, -8.43 -50.25, -44.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.445 APE9-dist-in 6.811 None None None XRAY 1.9 0.206 0.25 A 327 286 23 0 0 10 [[1116, 1385]] 1.0 4cnh TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4CTBA 1093 1402 1620.0 KVC:2402 Type1 Inactive DFGin 6.216 14.849 ABAminus -119.67, -9.24 -135.77, 135.53 -130.14, 34.99 293.83, 84.83 -68.92, -36.75 in-in in 7.801 Saltbr-in 3.083 HRD-in -73.33, -46.07 82.91, -9.21 in-out-out SNCioo out-out ActLoopNT-out 6.941 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.19, -13.84 APE9-dihe-in -65.2, 138.92 APE8-dihe-in -74.78, 60.38 APE8-rot-na 30.11 APE67-dihe-in -72.32, -8.28 -56.62, -34.41 APE12-dist-na 14.636 APE11-dist-na 14.997 APE10-dist-na 9.965 APE9-dist-out 8.001 None None None XRAY 1.79 0.21 0.247 A 327 293 17 0 0 6 [[1116, 1385]] 1.0 4ctb TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4CTCA 1094 1402 1620.0 J99:2402 Type1 Inactive DFGin 6.087 14.436 ABAminus -113.76, -13.97 -127.87, 134.88 -130.21, 34.39 296.92, 88.54 -69.58, -32.9 in-out in 7.818 Saltbr-out 4.663 HRD-in -68.52, -47.86 79.55, -14.18 out-out-out SNCooo out-out ActLoopNT-out 6.628 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.25, -22.21 APE9-dihe-in -63.2, 137.35 APE8-dihe-in -83.4, 68.98 APE8-rot-na 27.6 APE67-dihe-in -69.91, -15.73 -58.12, -29.13 APE12-dist-na 14.935 APE11-dist-na 15.258 APE10-dist-na 10.203 APE9-dist-in 7.824 None None None XRAY 2.03 0.194 0.216 A 327 289 20 0 0 8 [[1116, 1385]] 1.0 4ctc TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
5KZ0A 1093 1401 1620.0 6YL:1501 Type1 Inactive DFGin 5.922 14.406 ABAminus -133.15, -11.67 -127.06, 138.04 -132.87, 29.16 292.21, 94.94 -79.99, -2.4 in-out in 7.919 Saltbr-out 4.084 HRD-in -74.2, -39.11 78.61, -15.85 out-out-out SNCooo out-out ActLoopNT-out 6.835 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -92.46, -46.15 APE9-dihe-in -45.76, 137.83 APE8-dihe-in -84.92, 73.38 APE8-rot-na 33.7 APE67-dihe-in -73.49, -11.11 -70.16, -20.71 APE12-dist-na 15.231 APE11-dist-na 15.196 APE10-dist-na 10.044 APE9-dist-in 7.788 None None None XRAY 2.3 0.18 0.269 A 327 293 16 0 0 8 [[1116, 1385]] 1.0 5kz0 TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
7R7KA 1094 1400 1620.0 25J:1501 Type1 Inactive DFGin 6.296 14.799 ABAminus -117.03, -7.91 -132.86, 139.73 -133.05, 30.6 293.43, 91.77 -61.89, -44.97 in-out in 7.758 Saltbr-out 4.764 HRD-in -63.52, -48.31 78.95, -7.31 out-out-out SNCooo out-out ActLoopNT-out 6.906 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.56, -4.43 APE9-dihe-in -73.03, 141.44 APE8-dihe-in -80.52, 63.08 APE8-rot-na 29.68 APE67-dihe-in -66.55, -12.77 -43.97, -45.25 APE12-dist-na 14.143 APE11-dist-na 14.927 APE10-dist-na 9.807 APE9-dist-in 7.912 None None None XRAY 1.831 0.195 0.221 A 327 290 17 0 0 6 [[1116, 1385]] 1.0 7r7k TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
7R7RA 1093 1401 1620.0 AWJ:1501 Type1 Inactive DFGin 6.122 14.694 ABAminus -114.04, -10.1 -130.71, 138.84 -131.21, 32.52 294.04, 89.2 -62.61, -42.67 in-out in 8.025 Saltbr-out 4.75 HRD-in -66.43, -50.15 80.96, -9.24 out-out-out SNCooo out-out ActLoopNT-out 6.883 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -105.96, -19.38 APE9-dihe-in -67.0, 138.74 APE8-dihe-in -79.51, 69.3 APE8-rot-na 29.25 APE67-dihe-in -68.73, -13.21 -57.11, -32.66 APE12-dist-na 14.453 APE11-dist-na 14.973 APE10-dist-na 9.85 APE9-dist-in 7.728 None None None XRAY 1.935 0.193 0.227 A 327 291 18 0 0 7 [[1116, 1385]] 1.0 7r7r TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4FNZA 1093 1402 1620.0 NZF:1501 Type1 Inactive DFGin 5.291 12.8 ABAminus -135.46, 12.02 -152.76, 153.63 -83.97, -38.55 283.31, 122.35 73.66, 999.0 in-in in 8.5 Saltbr-in 2.812 HRD-in -72.66, -49.3 78.9, -9.45 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.65, -24.93 APE9-dihe-in -50.61, 132.71 APE8-dihe-in -79.34, 69.48 APE8-rot-na 27.73 APE67-dihe-in -74.42, -13.21 -56.44, -36.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.83 C1097S None None XRAY 2.6 0.202 0.261 A 327 287 23 0 0 15 [[1116, 1385]] 1.0 4fnz TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
5IUIA 1089 1400 1620.0 45Q:1501 Type1 Inactive DFGin 6.097 15.067 ABAminus -115.96, -40.57 -98.03, 131.36 -128.94, 30.02 290.16, 88.83 -67.06, -40.42 in-in in 8.173 Saltbr-in 2.935 HRD-in -74.44, -37.49 70.23, -3.09 in-out-out SNCioo out-out ActLoopNT-out 7.049 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -106.21, -6.36 APE9-dihe-in -64.31, 145.1 APE8-dihe-in -79.79, 58.82 APE8-rot-na 31.57 APE67-dihe-in -70.65, -5.92 -44.41, -46.15 APE12-dist-na 14.442 APE11-dist-na 15.056 APE10-dist-na 10.039 APE9-dist-out 8.117 C1097S None None XRAY 1.88 0.181 0.205 A 327 303 9 0 0 5 [[1116, 1385]] 1.0 5iui TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4FODA 1085 1405 1620.0 0UV:1501 Type1 Inactive DFGin 6.303 14.942 ABAminus -126.17, 8.88 -148.68, 139.13 -133.76, 30.42 294.7, 92.17 -67.04, -41.19 in-in in 7.487 Saltbr-in 2.605 HRD-in -73.82, -48.62 76.13, -0.28 in-out-out SNCioo out-out ActLoopNT-out 7.025 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -105.69, -7.83 APE9-dihe-in -60.03, 145.3 APE8-dihe-in -82.29, 62.32 APE8-rot-na 33.22 APE67-dihe-in -70.05, -10.83 -47.36, -42.53 APE12-dist-na 11.937 APE11-dist-na 15.069 APE10-dist-na 10.011 APE9-dist-in 7.843 C1097S None None XRAY 2.0 0.18 0.221 A 333 308 13 0 0 7 [[1116, 1385]] 1.0 4fod TYR_ALK_HUMAN TYR 1.5e-90 309.0 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
3AOXA 1086 1401 1620.0 EMH:901 Type1 Inactive DFGin 6.407 14.944 ABAminus -137.07, 23.28 -158.41, 139.16 -133.43, 27.21 291.39, 95.08 -65.65, -43.18 in-in in 7.657 Saltbr-in 2.594 HRD-in -71.98, -46.85 79.15, -6.33 in-out-out SNCioo out-out ActLoopNT-out 6.955 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -95.63, -6.24 APE9-dihe-in -65.1, 144.04 APE8-dihe-in -84.44, 65.15 APE8-rot-na 34.19 APE67-dihe-in -68.33, -10.93 -51.94, -40.89 APE12-dist-na 11.753 APE11-dist-na 14.962 APE10-dist-na 9.921 APE9-dist-in 7.992 None None None XRAY 1.75 0.17 0.206 A 344 298 18 0 0 7 [[1116, 1385]] 1.0 3aox TYR_ALK_HUMAN TYR 1.7e-90 308.8 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
5A9UA 1093 1402 1620.0 5P8:2402 Type1 Inactive DFGin 6.068 14.657 ABAminus -124.48, -3.05 -136.25, 135.66 -131.11, 34.63 291.44, 81.89 -72.61, -25.01 in-out in 8.133 Saltbr-out 3.838 HRD-in -74.43, -46.73 80.61, -9.35 out-out-out SNCooo out-out ActLoopNT-out 6.844 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.6, -12.67 APE9-dihe-in -61.75, 137.74 APE8-dihe-in -78.53, 58.82 APE8-rot-na 30.41 APE67-dihe-in -71.12, -10.64 -57.9, -28.42 APE12-dist-na 14.791 APE11-dist-na 15.374 APE10-dist-na 10.294 APE9-dist-out 8.143 C1156Y None None XRAY 1.6 0.216 0.258 A 327 293 17 0 0 6 [[1116, 1385]] 1.0 5a9u TYR_ALK_HUMAN TYR 1.9e-90 308.6 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
5AACA 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 6.049 14.948 ABAminus -115.19, -31.77 -111.83, 134.22 -128.43, 30.25 290.07, 81.16 -65.53, -32.88 in-out in 8.27 Saltbr-out 4.608 HRD-in -73.86, -46.4 82.42, -9.17 out-out-out SNCooo out-out ActLoopNT-out 6.925 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.47, -8.93 APE9-dihe-in -64.75, 135.46 APE8-dihe-in -76.69, 59.35 APE8-rot-na 30.37 APE67-dihe-in -71.48, -11.11 -59.44, -28.8 APE12-dist-na 14.745 APE11-dist-na 15.323 APE10-dist-na 10.293 APE9-dist-out 8.192 C1156Y None None XRAY 1.7 0.208 0.232 A 327 293 17 0 0 6 [[1116, 1385]] 1.0 5aac TYR_ALK_HUMAN TYR 1.9e-90 308.6 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
7BTTA 1093 1401 1620.0 F8R:1501 Type1 Inactive DFGin 6.156 14.786 ABAminus -122.03, -17.95 -119.49, 138.11 -134.22, 32.1 293.32, 88.16 -75.16, -36.17 in-in in 7.593 Saltbr-in 2.857 HRD-in -69.97, -43.61 74.45, -5.72 in-out-out SNCioo out-out ActLoopNT-out 7.027 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.06, -5.75 APE9-dihe-in -67.85, 139.87 APE8-dihe-in -78.72, 64.66 APE8-rot-na 32.81 APE67-dihe-in -71.63, -7.08 -50.37, -43.62 APE12-dist-na 14.563 APE11-dist-na 14.908 APE10-dist-na 9.821 APE9-dist-out 8.088 None None None XRAY 1.86 0.188 0.209 A 320 304 5 0 0 0 [[1116, 1385]] 1.0 7btt TYR_ALK_HUMAN TYR 3.9e-90 307.6 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4FOBA 1093 1402 1620.0 0US:1501 Type1 Inactive DFGin 6.203 14.608 ABAminus -121.93, -5.87 -135.31, 135.62 -128.54, 34.16 296.11, 87.18 -69.77, -38.85 in-in in 7.861 Saltbr-in 2.609 HRD-in -75.01, -47.81 80.74, -11.97 in-out-out SNCioo out-out ActLoopNT-out 6.963 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -99.67, -8.45 APE9-dihe-in -60.62, 141.15 APE8-dihe-in -80.22, 63.12 APE8-rot-na 30.66 APE67-dihe-in -69.42, -9.11 -51.4, -43.54 APE12-dist-na 14.346 APE11-dist-na 14.725 APE10-dist-na 9.646 APE9-dist-in 7.854 C1097S None None XRAY 1.9 0.203 0.255 A 353 295 15 0 0 6 [[1116, 1385]] 1.0 4fob TYR_ALK_HUMAN TYR 1.8e-90 308.8 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4FOCA 1093 1402 1620.0 0UU:1501 Type1 Inactive DFGin 6.324 14.569 ABAminus -123.54, -7.23 -132.63, 134.75 -129.46, 36.57 293.68, 84.81 -70.2, -37.62 in-in in 7.786 Saltbr-in 3.101 HRD-in -69.96, -48.47 78.5, -3.5 in-out-out SNCioo out-out ActLoopNT-out 6.988 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.01, -12.7 APE9-dihe-in -61.61, 144.79 APE8-dihe-in -84.7, 68.48 APE8-rot-na 34.22 APE67-dihe-in -73.32, -8.77 -52.28, -39.37 APE12-dist-na 12.056 APE11-dist-na 15.029 APE10-dist-na 9.917 APE9-dist-in 7.765 C1097S None None XRAY 1.7 0.191 0.225 A 353 296 14 0 0 8 [[1116, 1385]] 1.0 4foc TYR_ALK_HUMAN TYR 1.8e-90 308.8 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4Z55A 1093 1399 1620.0 4LO:1503 Type1 Inactive DFGin 6.253 14.635 ABAminus -123.6, 13.8 -145.92, 137.93 -133.07, 27.38 295.45, 90.97 -57.61, -49.96 in-in in 7.456 Saltbr-in 2.784 HRD-in -65.39, -47.79 76.59, -11.13 in-out-out SNCioo out-out ActLoopNT-out 6.872 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.75, -10.47 APE9-dihe-in -67.58, 140.18 APE8-dihe-in -79.19, 59.38 APE8-rot-na 31.88 APE67-dihe-in -66.53, -10.05 -40.3, -48.22 APE12-dist-na 14.877 APE11-dist-na 15.159 APE10-dist-na 10.085 APE9-dist-out 8.072 S1281G None None XRAY 1.55 0.185 0.208 A 339 294 13 0 0 1 [[1116, 1385]] 1.0 4z55 TYR_ALK_HUMAN TYR 4.7e-90 307.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
3LCSA 1096 1399 1620.0 STU:1 Type1 Inactive DFGin 6.33 14.912 ABAminus -115.64, -37.74 -102.74, 114.2 -112.42, 20.01 289.12, 86.66 -56.01, -38.26 in-in in 7.78 Saltbr-in 2.662 HRD-in -69.52, -44.32 78.89, -12.54 in-out-out SNCioo out-out ActLoopNT-out 6.794 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.07, -13.05 APE9-dihe-in -64.04, 139.47 APE8-dihe-in -80.51, 60.39 APE8-rot-na 31.54 APE67-dihe-in -67.01, -14.6 -60.37, -27.86 APE12-dist-na 15.308 APE11-dist-na 15.569 APE10-dist-na 10.539 APE9-dist-out 8.296 S1281G None None XRAY 1.95 0.196 0.229 A 344 304 0 0 0 0 [[1116, 1385]] 1.0 3lcs TYR_ALK_HUMAN TYR 5e-90 307.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4MKCA 1093 1401 1620.0 4MK:1503 Type1 Inactive DFGin 6.142 14.787 ABAminus -119.13, 7.31 -142.69, 137.29 -134.51, 29.61 298.97, 84.4 -59.55, -42.66 in-in in 7.656 Saltbr-in 2.864 HRD-in -66.46, -45.49 70.41, -4.89 in-out-out SNCioo out-out ActLoopNT-out 6.896 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.61, -14.66 APE9-dihe-in -63.04, 142.03 APE8-dihe-in -82.73, 64.43 APE8-rot-na 33.65 APE67-dihe-in -65.02, -10.82 -49.18, -45.64 APE12-dist-na 14.918 APE11-dist-na 15.251 APE10-dist-na 10.205 APE9-dist-out 8.118 S1281G None None XRAY 2.01 0.173 0.218 A 367 303 6 0 0 0 [[1116, 1385]] 1.0 4mkc TYR_ALK_HUMAN TYR 6.2e-90 307.0 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
9GBEA 1086 1401 1620.0 A1IJ8:1501 Type1 Inactive DFGin 6.226 14.835 ABAminus -118.03, -13.57 -139.47, 137.54 -132.04, 28.84 289.39, 90.38 -67.89, -35.38 in-in in 7.85 Saltbr-in 2.71 HRD-in -70.68, -49.03 81.56, -8.45 in-out-out SNCioo out-out ActLoopNT-out 6.913 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.96, -12.0 APE9-dihe-in -66.08, 139.0 APE8-dihe-in -79.17, 64.92 APE8-rot-na 34.36 APE67-dihe-in -67.16, -14.31 -60.07, -32.34 APE12-dist-na 14.167 APE11-dist-na 15.029 APE10-dist-na 9.892 APE9-dist-out 8.07 L1196M,G1202R None None XRAY 1.58 0.186 0.224 A 344 304 12 0 0 6 [[1116, 1385]] 1.0 9gbe TYR_ALK_HUMAN TYR 3.3e-89 304.6 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4CNHB 1093 1401 1620.0 3U9:2401,3U9:2402 Type1,Allosteric Inactive DFGin 4.339 12.327 ABAminus -115.59, -14.06 -164.87, 163.73 -86.41, -10.43 302.46, 115.44 53.37, -130.64 in-in in 8.072 Saltbr-in 2.629 HRD-in -84.33, -49.79 83.6, -11.29 in-out-out SNCioo out-out ActLoopNT-out 8.549 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -91.6, -17.34 APE9-dihe-in -73.51, 138.4 APE8-dihe-in -77.48, 68.43 APE8-rot-na 27.84 APE67-dihe-in -66.22, -13.37 -69.94, -19.9 APE12-dist-na 12.784 APE11-dist-na 13.464 APE10-dist-na 8.385 APE9-dist-out 8.684 None None None XRAY 1.9 0.206 0.25 B 327 294 15 0 0 5 [[1116, 1385]] 1.0 4cnh TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4JOAA 1107 1398 1620.0 3DK:1501 Type1.5_Front Inactive DFGin 5.651 15.18 ABAminus -99.28, -25.44 -116.97, 136.23 -132.09, 28.46 289.09, 82.31 -66.18, -40.48 in-out in 8.532 Saltbr-out 7.323 HRD-in -79.35, -45.13 67.79, 9.59 out-out-out SNCooo out-out ActLoopNT-out 6.633 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -75.97, -11.03 APE9-dihe-in -75.81, 135.85 APE8-dihe-in -79.69, 75.84 APE8-rot-na 32.08 APE67-dihe-in -70.53, -20.07 -69.09, -33.02 APE12-dist-na 999.0 APE11-dist-na 15.099 APE10-dist-na 10.28 APE9-dist-out 8.098 S1281G None None XRAY 2.7 0.253 0.29 A 344 251 41 0 0 9 [[1116, 1385]] 1.0 4joa TYR_ALK_HUMAN TYR 5e-90 307.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
2YJRA 1101 1402 1620.0 No_ligand No_ligand Inactive DFGin 6.309 14.703 None -109.22, -156.6 -24.57, 131.48 -106.45, 12.37 294.91, 66.22 -54.96, -56.35 in-in in 7.943 Saltbr-in 3.124 HRD-in -78.17, -44.51 78.03, -12.49 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -91.23, -22.26 APE9-dihe-in -61.19, 130.79 APE8-dihe-in -74.37, 65.56 APE8-rot-na 28.22 APE67-dihe-in -67.2, -14.23 -60.39, -32.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.855 F1174L None None XRAY 1.9 0.221 0.281 A 342 281 21 0 0 14 [[1116, 1385]] 1.0 2yjr TYR_ALK_HUMAN TYR 1.3e-90 309.2 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
6EDLA 1093 1399 1620.0 J4M:1500 Type1 Inactive DFGin 5.742 13.999 None -126.77, 7.53 -146.28, 139.77 -129.2, 999.0 286.43, 88.97 999.0, 999.0 in-in in 8.043 Saltbr-in 3.203 HRD-in -75.33, -45.54 75.3, -3.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -90.79, -15.28 APE9-dihe-in -62.49, 138.06 APE8-dihe-in -76.58, 62.31 APE8-rot-na 33.87 APE67-dihe-in -71.34, -10.1 -42.44, -41.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.115 None None None XRAY 2.799 0.231 0.282 A 322 282 25 0 0 16 [[1116, 1385]] 1.0 6edl TYR_ALK_HUMAN TYR 1.3e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
5IMXA 1109 1400 1620.0 CZ4:1501 Type1 Inactive DFGin 5.034 14.449 None -109.53, -14.09 -148.27, 147.07 -105.7, 146.52 283.91, 86.87 -67.35, -107.72 in-in in 8.028 Saltbr-in 2.504 HRD-in -65.65, -55.77 80.57, -2.35 in-out-out SNCioo out-out ActLoopNT-out 7.558 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -82.05, -3.8 APE9-dihe-in -82.72, 146.31 APE8-dihe-in -87.12, 68.37 APE8-rot-na 16.28 APE67-dihe-in -69.01, -16.06 -50.43, -36.09 APE12-dist-na 10.904 APE11-dist-na 15.562 APE10-dist-na 10.632 APE9-dist-in 7.972 None None None XRAY 2.12 0.213 0.259 A 327 266 26 0 0 10 [[1116, 1385]] 1.0 5imx TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4DCEA 1093 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.63 13.823 None -137.27, 16.47 -161.52, 152.14 -94.73, 164.26 291.72, 122.64 -76.17, 999.0 in-in in 8.482 Saltbr-in 2.883 HRD-in -75.4, -48.78 85.77, -10.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.83, -20.84 APE9-dihe-in -55.51, 136.7 APE8-dihe-in -77.28, 70.08 APE8-rot-na 28.6 APE67-dihe-in -68.31, -8.92 -56.77, -41.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.974 C1097S None None XRAY 2.03 0.211 0.256 A 333 288 22 0 0 14 [[1116, 1385]] 1.0 4dce TYR_ALK_HUMAN TYR 1.5e-90 309.0 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4DCEB 1094 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.747 13.628 None -141.04, 18.73 -165.26, 150.02 -96.5, 167.37 286.77, 120.17 -70.38, 999.0 in-in in 8.563 Saltbr-in 2.99 HRD-in -72.56, -48.26 83.87, -14.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.41, -12.56 APE9-dihe-in -59.98, 136.0 APE8-dihe-in -80.48, 64.18 APE8-rot-na 31.8 APE67-dihe-in -66.1, -14.3 -52.07, -41.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.713 C1097S None None XRAY 2.03 0.211 0.256 B 333 284 25 0 0 15 [[1116, 1385]] 1.0 4dce TYR_ALK_HUMAN TYR 1.5e-90 309.0 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
5IUGA 1093 1404 1620.0 729:1501 Type2 Inactive DFGout 14.153 9.999 BBAminus -131.11, -160.99 -160.87, 113.54 -82.67, -13.49 278.51, 100.05 82.21, 14.97 in-in in 7.669 Saltbr-in 3.074 HRD-in -68.79, -47.96 74.11, -0.87 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.37, -10.99 APE9-dihe-in -66.27, 131.08 APE8-dihe-in -74.93, 62.41 APE8-rot-na 32.11 APE67-dihe-in -72.28, -10.91 -51.72, -32.16 APE12-dist-na 14.999 APE11-dist-na 12.817 APE10-dist-na 7.9 APE9-dist-out 8.42 C1097S None None XRAY 1.93 0.184 0.211 A 327 285 27 0 0 12 [[1116, 1385]] 1.0 5iug TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
5IUHA 1093 1404 1620.0 34Y:1501 Type2 Inactive DFGout 14.232 10.118 BBAminus -138.56, -161.58 -159.14, 110.88 -77.24, -9.47 279.89, 100.17 78.06, 14.37 in-in in 7.62 Saltbr-in 2.988 HRD-in -72.63, -47.58 76.22, -3.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -97.17, -17.0 APE9-dihe-in -66.13, 131.14 APE8-dihe-in -77.12, 65.41 APE8-rot-na 31.95 APE67-dihe-in -67.53, -10.9 -52.9, -35.57 APE12-dist-na 14.94 APE11-dist-na 12.961 APE10-dist-na 8.224 APE9-dist-out 8.544 C1097S None None XRAY 2.1 0.183 0.221 A 327 285 27 0 0 13 [[1116, 1385]] 1.0 5iuh TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
4FNYA 1103 1404 1620.0 I3K:1501 Type2 Inactive DFGout 14.184 10.088 None -127.21, -165.1 -161.64, 122.7 -96.04, 999.0 291.91, 90.85 999.0, 999.0 in-in in 7.899 Saltbr-in 2.528 HRD-in -68.56, -48.94 76.07, 1.7 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.3, -24.9 APE9-dihe-in -67.06, 137.93 APE8-dihe-in -72.43, 66.19 APE8-rot-na 27.5 APE67-dihe-in -66.24, -16.71 -48.34, -39.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.214 C1097S,R1275Q None None XRAY 2.45 0.196 0.252 A 327 273 29 0 0 16 [[1116, 1385]] 1.0 4fny TYR_ALK_HUMAN TYR 3.6e-90 307.7 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor

TYR_ALK (ALK tyrosine kinase receptor)

Total number of chains: 68
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 58 85.3% 3LCSA
DFGin None 5 7.4% 2YJRA
DFGin BLAminus 2 2.9% AF-Q9UM73-K1A
DFGout BBAminus 2 2.9% 5IUGA
DFGout None 1 1.5% 4FNYA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ALK_HUMAN AF-Q9UM73-K1A Q9UM73 1108 1393 1620.0 No_ligand No_ligand Active DFGin 5.946 14.375 BLAminus -128.36, -171.81 51.94, 77.78 -92.22, 15.36 286.64, 85.92 -56.6, -33.49 in-in in 7.977 Saltbr-in 2.631 HRD-in -84.5, -39.96 65.84, -13.69 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.67, 132.62 APE9-dihe-in -132.53, 142.2 APE8-dihe-in -77.98, 67.6 APE8-rot-na 34.24 APE67-dihe-in -67.7, -9.18 -47.25, -44.33 APE12-dist-na 15.19 APE11-dist-na 9.617 APE10-dist-na 10.461 APE9-dist-in 7.204 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[1116, 1385]] 1.0 AF-Q9UM73-K1 Homo sapiens TYR_ALK_HUMAN TYR 8.6e-91 309.7 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN AF-Q9UM73-K3A Q9UM73 1108 1393 1620.0 No_ligand No_ligand Active DFGin 6.052 13.607 BLAminus -131.74, -170.01 51.86, 66.91 -83.62, 16.51 291.43, 91.58 -58.46, -31.87 in-in in 8.079 Saltbr-in 2.687 HRD-in -85.25, -38.15 64.37, 4.14 in-in-in SNCiii in-in ActLoopNT-in 2.867 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.58, 98.52 APE9-dihe-in -103.22, 145.61 APE8-dihe-in -72.6, 70.7 APE8-rot-na 33.25 APE67-dihe-in -77.31, -3.9 -52.0, -31.13 APE12-dist-na 16.467 APE11-dist-na 10.435 APE10-dist-na 11.254 APE9-dist-in 7.285 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[1116, 1385]] 1.0 AF-Q9UM73-K3 Homo sapiens TYR_ALK_HUMAN TYR 8.6e-91 309.7 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 3LCTA Q9UM73 1093 1400 1620.0 ADP:1412 ATPlike Inactive DFGin 6.266 15.193 ABAminus -127.22, 10.26 -136.37, 129.73 -130.23, 18.7 291.41, 88.16 -49.74, -46.74 in-none in 8.1 Saltbr-none 999.0 HRD-in -78.72, -45.58 81.21, -3.39 none-out-out SNCnoo out-out ActLoopNT-out 6.886 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -94.62, -10.42 APE9-dihe-in -67.88, 140.77 APE8-dihe-in -81.63, 62.42 APE8-rot-na 34.08 APE67-dihe-in -66.16, -16.53 -61.79, -27.56 APE12-dist-na 14.739 APE11-dist-na 15.112 APE10-dist-na 9.981 APE9-dist-out 8.031 S1281G None None XRAY 2.1 0.207 0.255 A 344 308 0 0 0 0 [[1116, 1385]] 1.0 3lct Homo sapiens TYR_ALK_HUMAN TYR 5e-90 307.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4TT7A Q9UM73 1095 1400 1620.0 COM:61501,COM:61502 Allosteric,Allosteric Inactive DFGin 6.331 15.104 ABAminus -129.34, 13.94 -143.37, 136.26 -133.45, 29.15 287.86, 86.47 -61.1, -46.06 in-in in 8.276 Saltbr-in 2.899 HRD-in -65.35, -47.66 76.28, -7.96 in-out-out SNCioo out-out ActLoopNT-out 6.717 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -97.0, -10.73 APE9-dihe-in -72.98, 131.19 APE8-dihe-in -73.54, 64.64 APE8-rot-na 32.16 APE67-dihe-in -68.68, -12.97 -52.76, -40.18 APE12-dist-na 14.946 APE11-dist-na 15.258 APE10-dist-na 10.088 APE9-dist-out 8.134 None None None XRAY 2.1 0.195 0.244 A 325 290 16 0 0 2 [[1116, 1385]] 1.0 4tt7 Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 7JY4A Q9UM73 1096 1399 1620.0 W47:1701,W47:1702 Allosteric,Type1 Inactive DFGin 5.92 14.519 ABAminus -113.43, -9.3 -142.4, 138.16 -131.48, 29.53 294.61, 83.59 -63.18, -27.52 in-out in 7.579 Saltbr-out 4.289 HRD-in -66.41, -52.1 72.58, 14.97 out-out-out SNCooo out-out ActLoopNT-out 6.665 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.55, -8.29 APE9-dihe-in -68.93, 134.74 APE8-dihe-in -72.25, 67.62 APE8-rot-na 30.54 APE67-dihe-in -68.71, -7.15 -58.46, -37.5 APE12-dist-na 14.864 APE11-dist-na 15.637 APE10-dist-na 10.484 APE9-dist-out 8.472 None None None XRAY 2.42 0.221 0.255 A 322 290 14 0 0 7 [[1116, 1385]] 1.0 7jy4 Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 2YHVA Q9UM73 1093 1401 1620.0 No_ligand No_ligand Inactive DFGin 6.292 15.188 ABAminus -123.67, -1.11 -136.06, 135.4 -132.07, 27.87 288.99, 87.09 -68.12, -28.8 in-out in 8.007 Saltbr-out 4.973 HRD-in -77.85, -44.61 80.59, -11.15 out-out-out SNCooo out-out ActLoopNT-out 6.971 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.52, -6.03 APE9-dihe-in -64.98, 136.8 APE8-dihe-in -78.21, 58.76 APE8-rot-na 28.31 APE67-dihe-in -70.14, -11.55 -58.4, -31.21 APE12-dist-na 14.583 APE11-dist-na 15.003 APE10-dist-na 10.002 APE9-dist-out 8.103 L1196M None None XRAY 1.9 0.206 0.238 A 342 292 17 0 0 6 [[1116, 1385]] 1.0 2yhv Homo sapiens TYR_ALK_HUMAN TYR 6e-91 310.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4ANLA Q9UM73 1094 1402 1620.0 No_ligand No_ligand Inactive DFGin 6.319 15.074 ABAminus -122.56, -44.06 -97.45, 124.8 -122.56, 30.81 292.45, 83.3 -66.54, -36.82 in-out in 8.023 Saltbr-out 4.852 HRD-in -74.81, -43.42 79.26, -10.5 out-out-out SNCooo out-out ActLoopNT-out 6.976 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.21, -6.47 APE9-dihe-in -62.46, 134.19 APE8-dihe-in -75.42, 58.77 APE8-rot-na 29.27 APE67-dihe-in -71.73, -7.68 -54.8, -34.96 APE12-dist-na 14.376 APE11-dist-na 14.79 APE10-dist-na 9.85 APE9-dist-out 8.04 G1269A None None XRAY 1.7 0.202 0.216 A 342 293 16 0 0 6 [[1116, 1385]] 1.0 4anl Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4FNWA Q9UM73 1084 1405 1620.0 No_ligand No_ligand Inactive DFGin 6.266 14.909 ABAminus -118.46, -25.35 -118.23, 130.17 -123.97, 30.37 289.23, 85.23 -66.19, -35.54 in-in in 7.973 Saltbr-in 3.271 HRD-in -71.6, -47.27 80.64, -6.43 in-out-out SNCioo out-out ActLoopNT-out 7.009 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.87, -11.88 APE9-dihe-in -57.72, 142.89 APE8-dihe-in -82.66, 63.25 APE8-rot-na 32.43 APE67-dihe-in -71.06, -7.27 -50.06, -41.71 APE12-dist-na 11.921 APE11-dist-na 15.101 APE10-dist-na 10.055 APE9-dist-in 7.916 C1097S,F1174L None None XRAY 1.75 0.181 0.203 A 327 304 18 0 0 8 [[1116, 1385]] 1.0 4fnw Homo sapiens TYR_ALK_HUMAN TYR 1.1e-90 309.4 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4FNXA Q9UM73 1093 1404 1620.0 No_ligand No_ligand Inactive DFGin 6.056 14.83 ABAminus -115.68, -17.57 -132.37, 141.55 -132.11, 50.23 294.37, 89.4 -81.69, -11.71 in-in in 7.879 Saltbr-in 2.9 HRD-in -67.87, -45.92 63.48, 21.39 in-out-out SNCioo out-out ActLoopNT-out 8.796 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.41, -1.04 APE9-dihe-in -70.97, 126.88 APE8-dihe-in -77.01, 61.37 APE8-rot-na 28.92 APE67-dihe-in -68.85, -9.84 -51.53, -36.34 APE12-dist-na 12.798 APE11-dist-na 16.426 APE10-dist-na 11.551 APE9-dist-out 8.771 C1097S,R1275Q None None XRAY 1.7 0.196 0.23 A 327 292 20 0 0 9 [[1116, 1385]] 1.0 4fnx Homo sapiens TYR_ALK_HUMAN TYR 3.6e-90 307.7 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 6CDTA Q9UM73 1093 1400 1620.0 No_ligand No_ligand Inactive DFGin 6.3 15.124 ABAminus -123.35, -15.42 -125.06, 128.52 -124.36, 30.18 290.06, 83.02 -64.75, -38.93 in-out in 7.995 Saltbr-out 4.979 HRD-in -72.97, -44.41 80.06, -9.45 out-out-out SNCooo out-out ActLoopNT-out 7.024 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -101.22, -7.31 APE9-dihe-in -65.06, 137.47 APE8-dihe-in -74.57, 60.9 APE8-rot-na 29.07 APE67-dihe-in -75.35, -6.12 -48.18, -42.21 APE12-dist-na 14.453 APE11-dist-na 14.779 APE10-dist-na 9.783 APE9-dist-in 7.861 None None None XRAY 1.8 0.196 0.226 A 327 292 16 0 0 6 [[1116, 1385]] 1.0 6cdt Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 2YJSA Q9UM73 1094 1402 1620.0 No_ligand No_ligand Inactive DFGin 5.933 15.066 ABAminus -121.83, -11.53 -129.45, 132.48 -129.61, 30.1 290.02, 84.24 -67.53, -32.65 in-out in 8.529 Saltbr-out 3.759 HRD-in -74.02, -46.25 80.81, -7.98 out-out-out SNCooo out-out ActLoopNT-out 6.963 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -95.71, -13.28 APE9-dihe-in -61.54, 135.1 APE8-dihe-in -77.63, 61.25 APE8-rot-na 30.06 APE67-dihe-in -69.46, -13.22 -55.44, -32.78 APE12-dist-na 14.159 APE11-dist-na 15.268 APE10-dist-na 10.268 APE9-dist-out 8.189 C1156Y None None XRAY 1.9 0.211 0.243 A 342 290 19 0 0 8 [[1116, 1385]] 1.0 2yjs Homo sapiens TYR_ALK_HUMAN TYR 2.2e-90 308.4 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 3L9PA Q9UM73 1093 1400 1620.0 No_ligand No_ligand Inactive DFGin 6.219 15.156 ABAminus -126.0, -1.93 -131.15, 131.2 -131.41, 25.42 291.27, 88.64 -59.73, -44.21 in-none in 7.982 Saltbr-none 999.0 HRD-in -69.61, -44.54 77.55, -8.47 none-out-out SNCnoo out-out ActLoopNT-out 6.883 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.3, -11.47 APE9-dihe-in -69.19, 138.58 APE8-dihe-in -80.43, 62.6 APE8-rot-na 32.84 APE67-dihe-in -67.59, -13.49 -45.09, -43.43 APE12-dist-na 14.948 APE11-dist-na 15.11 APE10-dist-na 10.009 APE9-dist-in 7.904 S1281G None None XRAY 1.8 0.192 0.226 A 367 303 5 0 0 0 [[1116, 1385]] 1.0 3l9p Homo sapiens TYR_ALK_HUMAN TYR 6.2e-90 307.0 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4ANSA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 6.248 15.162 ABAminus -128.23, -41.44 -98.11, 120.9 -117.53, 30.59 287.81, 85.26 -66.49, -38.26 in-out in 8.265 Saltbr-out 4.892 HRD-in -72.85, -44.3 78.64, -9.03 out-out-out SNCooo out-out ActLoopNT-out 6.908 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.15, -7.92 APE9-dihe-in -66.26, 134.84 APE8-dihe-in -77.14, 60.8 APE8-rot-na 30.33 APE67-dihe-in -70.27, -10.51 -58.92, -29.59 APE12-dist-na 14.661 APE11-dist-na 14.883 APE10-dist-na 9.857 APE9-dist-out 8.039 L1196M,G1269A None None XRAY 1.85 0.201 0.231 A 342 294 16 0 0 6 [[1116, 1385]] 1.0 4ans Homo sapiens TYR_ALK_HUMAN TYR 5.2e-91 310.5 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 2YFXA Q9UM73 1093 1401 1620.0 VGH:9000 Type1 Inactive DFGin 6.221 14.881 ABAminus -122.22, -28.6 -114.9, 132.72 -127.11, 33.52 293.03, 85.04 -65.89, -37.73 in-out in 7.914 Saltbr-out 4.75 HRD-in -73.95, -43.63 78.32, -9.23 out-out-out SNCooo out-out ActLoopNT-out 6.956 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.12, -9.34 APE9-dihe-in -61.51, 137.47 APE8-dihe-in -77.72, 57.54 APE8-rot-na 29.78 APE67-dihe-in -70.24, -8.94 -56.4, -32.44 APE12-dist-na 14.505 APE11-dist-na 14.933 APE10-dist-na 9.92 APE9-dist-out 8.05 L1196M None None XRAY 1.7 0.208 0.234 A 327 293 16 0 0 6 [[1116, 1385]] 1.0 2yfx Homo sapiens TYR_ALK_HUMAN TYR 5.1e-91 310.5 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4CLJA Q9UM73 1094 1402 1620.0 5P8:2402 Type1 Inactive DFGin 6.203 14.805 ABAminus -125.62, -0.02 -140.07, 135.04 -130.43, 32.34 295.46, 85.14 -65.98, -39.5 in-in in 8.011 Saltbr-in 2.711 HRD-in -71.97, -45.96 80.49, -8.87 in-out-out SNCioo out-out ActLoopNT-out 6.963 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.51, -5.34 APE9-dihe-in -68.88, 140.43 APE8-dihe-in -76.17, 58.33 APE8-rot-na 29.07 APE67-dihe-in -72.79, -6.46 -47.28, -42.69 APE12-dist-na 14.558 APE11-dist-na 14.807 APE10-dist-na 9.789 APE9-dist-in 7.937 L1196M None None XRAY 1.66 0.197 0.229 A 327 296 13 0 0 6 [[1116, 1385]] 1.0 4clj Homo sapiens TYR_ALK_HUMAN TYR 5.1e-91 310.5 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4CD0A Q9UM73 1094 1402 1620.0 AWJ:1500 Type1 Inactive DFGin 6.21 14.807 ABAminus -124.48, -7.47 -131.66, 141.46 -133.85, 29.84 290.85, 86.66 -65.46, -35.12 in-in in 7.711 Saltbr-in 2.745 HRD-in -77.45, -47.18 84.39, -11.38 in-out-out SNCioo out-out ActLoopNT-out 6.887 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.9, -13.71 APE9-dihe-in -68.46, 134.66 APE8-dihe-in -73.25, 65.7 APE8-rot-na 30.38 APE67-dihe-in -69.89, -9.61 -53.98, -40.39 APE12-dist-na 14.705 APE11-dist-na 14.91 APE10-dist-na 9.725 APE9-dist-in 7.976 L1196M None None XRAY 2.23 0.198 0.25 A 342 296 13 0 0 6 [[1116, 1385]] 1.0 4cd0 Homo sapiens TYR_ALK_HUMAN TYR 6e-91 310.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4ANQA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 6.209 14.974 ABAminus -128.3, -36.39 -101.79, 127.42 -123.56, 31.99 288.31, 85.14 -69.12, -35.87 in-out in 8.27 Saltbr-out 4.789 HRD-in -73.02, -46.15 80.91, -7.4 out-out-out SNCooo out-out ActLoopNT-out 6.947 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -98.41, -8.07 APE9-dihe-in -67.75, 134.94 APE8-dihe-in -74.89, 59.28 APE8-rot-na 29.64 APE67-dihe-in -70.46, -10.96 -58.56, -29.68 APE12-dist-na 14.724 APE11-dist-na 14.955 APE10-dist-na 9.922 APE9-dist-out 8.019 G1269A None None XRAY 1.76 0.201 0.217 A 342 294 16 0 0 6 [[1116, 1385]] 1.0 4anq Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 5AA9A Q9UM73 1093 1402 1620.0 5P8:2402 Type1 Inactive DFGin 6.182 14.891 ABAminus -123.86, -6.83 -134.63, 136.55 -132.06, 29.87 289.56, 85.44 -66.04, -35.64 in-out in 8.157 Saltbr-out 4.537 HRD-in -75.17, -44.12 79.72, -10.27 out-out-out SNCooo out-out ActLoopNT-out 6.848 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.37, -11.88 APE9-dihe-in -67.63, 135.25 APE8-dihe-in -76.86, 63.04 APE8-rot-na 30.41 APE67-dihe-in -70.03, -11.65 -60.61, -27.66 APE12-dist-na 14.916 APE11-dist-na 15.23 APE10-dist-na 10.096 APE9-dist-out 8.159 L1198F None None XRAY 1.93 0.201 0.237 A 327 296 14 0 0 6 [[1116, 1385]] 1.0 5aa9 Homo sapiens TYR_ALK_HUMAN TYR 4.4e-91 310.7 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 5AAAA Q9UM73 1093 1401 1620.0 VGH:9000 Type1 Inactive DFGin 6.209 14.916 ABAminus -119.08, -27.29 -116.14, 136.82 -130.64, 32.52 289.46, 85.69 -67.72, -37.15 in-out in 7.969 Saltbr-out 4.67 HRD-in -74.4, -45.03 79.43, -9.27 out-out-out SNCooo out-out ActLoopNT-out 6.898 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.98, -3.96 APE9-dihe-in -73.12, 136.6 APE8-dihe-in -77.4, 61.62 APE8-rot-na 28.9 APE67-dihe-in -71.26, -10.51 -60.21, -28.6 APE12-dist-na 14.555 APE11-dist-na 14.849 APE10-dist-na 9.8 APE9-dist-out 8.03 L1198F None None XRAY 1.73 0.201 0.206 A 327 295 14 0 0 6 [[1116, 1385]] 1.0 5aaa Homo sapiens TYR_ALK_HUMAN TYR 4.4e-91 310.7 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 5AA8A Q9UM73 1093 1402 1620.0 5P8:2402 Type1 Inactive DFGin 6.086 14.918 ABAminus -121.09, -8.69 -130.71, 131.76 -128.08, 33.6 288.19, 85.62 -75.96, -22.55 in-out in 8.245 Saltbr-out 4.485 HRD-in -76.73, -45.37 80.25, -8.63 out-out-out SNCooo out-out ActLoopNT-out 6.799 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.53, -15.21 APE9-dihe-in -61.78, 135.61 APE8-dihe-in -77.32, 62.22 APE8-rot-na 29.6 APE67-dihe-in -71.9, -11.44 -60.22, -27.26 APE12-dist-na 14.682 APE11-dist-na 15.552 APE10-dist-na 10.481 APE9-dist-out 8.188 C1156Y,L1198F None None XRAY 1.86 0.209 0.233 A 327 293 17 0 0 6 [[1116, 1385]] 1.0 5aa8 Homo sapiens TYR_ALK_HUMAN TYR 5.9e-91 310.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 5AABA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 5.962 14.941 ABAminus -122.06, -28.4 -115.22, 132.25 -127.31, 26.85 289.37, 81.1 -65.12, -33.9 in-out in 8.083 Saltbr-out 4.27 HRD-in -73.35, -48.11 83.65, -8.17 out-out-out SNCooo out-out ActLoopNT-out 6.963 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.88, -2.64 APE9-dihe-in -78.59, 133.38 APE8-dihe-in -74.05, 62.22 APE8-rot-na 30.08 APE67-dihe-in -71.71, -12.93 -64.03, -23.79 APE12-dist-na 15.1 APE11-dist-na 15.205 APE10-dist-na 10.087 APE9-dist-out 8.086 C1156Y,L1198F None None XRAY 2.2 0.211 0.246 A 327 294 16 0 0 6 [[1116, 1385]] 1.0 5aab Homo sapiens TYR_ALK_HUMAN TYR 5.9e-91 310.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 6MX8A Q9UM73 1094 1400 1620.0 6GY:1500 Type1 Inactive DFGin 6.142 14.662 ABAminus -114.12, -38.77 -118.14, 138.18 -129.19, 26.62 289.5, 87.05 -61.73, -41.9 in-in in 7.786 Saltbr-in 3.234 HRD-in -72.93, -50.14 84.31, -4.9 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.89, -3.2 APE9-dihe-in -73.94, 138.53 APE8-dihe-in -85.7, 68.86 APE8-rot-na 37.09 APE67-dihe-in -74.13, -8.15 -48.67, -39.52 APE12-dist-na 14.244 APE11-dist-na 15.184 APE10-dist-na 10.084 APE9-dist-out 8.168 None None None XRAY 1.96 0.185 0.227 A 307 282 25 0 0 13 [[1116, 1385]] 1.0 6mx8 Homo sapiens TYR_ALK_HUMAN TYR 1.1e-90 309.4 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 2XB7A Q9UM73 1095 1401 1620.0 GUI:1501 Type1 Inactive DFGin 5.731 14.599 ABAminus -132.42, -0.18 -141.44, 142.16 -131.03, 43.77 292.96, 89.17 -72.28, -38.54 in-in in 7.532 Saltbr-in 3.184 HRD-in -87.04, -46.67 85.76, -13.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.32, -3.08 APE9-dihe-in -73.74, 136.06 APE8-dihe-in -78.24, 56.9 APE8-rot-na 30.55 APE67-dihe-in -70.57, -6.09 -40.69, -40.8 APE12-dist-na 999.0 APE11-dist-na 15.273 APE10-dist-na 10.496 APE9-dist-out 8.336 None None None XRAY 2.5 0.195 0.243 A 315 286 21 0 0 14 [[1116, 1385]] 1.0 2xb7 Homo sapiens TYR_ALK_HUMAN TYR 1.2e-90 309.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 2XBAA Q9UM73 1095 1402 1620.0 571:1501 Type1 Inactive DFGin 6.085 14.874 ABAminus -122.73, -16.28 -123.08, 138.16 -132.25, 31.45 293.73, 90.75 -70.57, -36.09 in-in in 7.995 Saltbr-in 2.825 HRD-in -75.43, -45.29 77.63, -4.66 in-out-out SNCioo out-out ActLoopNT-out 6.994 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.39, 0.87 APE9-dihe-in -70.63, 140.95 APE8-dihe-in -81.29, 62.03 APE8-rot-na 33.35 APE67-dihe-in -68.85, -9.81 -51.55, -41.48 APE12-dist-na 999.0 APE11-dist-na 14.9 APE10-dist-na 9.915 APE9-dist-out 8.105 None None None XRAY 1.95 0.195 0.229 A 315 284 24 0 0 10 [[1116, 1385]] 1.0 2xba Homo sapiens TYR_ALK_HUMAN TYR 1.2e-90 309.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 5FTOA Q9UM73 1094 1401 1620.0 YMX:62402 Type1 Inactive DFGin 6.614 15.103 ABAminus -123.37, 0.05 -137.72, 139.58 -135.41, 24.82 289.1, 90.09 -60.28, -46.38 in-in in 7.802 Saltbr-in 2.713 HRD-in -72.55, -46.15 82.21, -13.13 in-out-out SNCioo out-out ActLoopNT-out 7.089 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -91.32, -8.05 APE9-dihe-in -57.49, 136.7 APE8-dihe-in -78.81, 60.16 APE8-rot-na 28.18 APE67-dihe-in -67.52, -8.47 -48.73, -45.52 APE12-dist-na 11.517 APE11-dist-na 14.857 APE10-dist-na 9.821 APE9-dist-in 7.967 None None None XRAY 2.22 0.199 0.257 A 315 297 11 0 0 7 [[1116, 1385]] 1.0 5fto Homo sapiens TYR_ALK_HUMAN TYR 1.2e-90 309.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 5FTQA Q9UM73 1094 1401 1620.0 U4W:62402 Type1 Inactive DFGin 6.538 14.825 ABAminus -118.64, -8.41 -138.53, 135.08 -126.73, 26.7 295.74, 85.6 -58.63, -49.74 in-in in 7.605 Saltbr-in 2.579 HRD-in -70.78, -46.77 80.03, 2.04 in-out-out SNCioo out-out ActLoopNT-out 6.929 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.78, -4.85 APE9-dihe-in -67.75, 140.01 APE8-dihe-in -77.42, 62.81 APE8-rot-na 24.56 APE67-dihe-in -73.5, -8.73 -54.41, -36.36 APE12-dist-na 12.688 APE11-dist-na 14.956 APE10-dist-na 9.921 APE9-dist-in 7.795 None None None XRAY 1.7 0.175 0.22 A 315 292 16 0 0 8 [[1116, 1385]] 1.0 5ftq Homo sapiens TYR_ALK_HUMAN TYR 1.2e-90 309.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 8ARJA Q9UM73 1103 1399 1620.0 NRR:1501 Type1 Inactive DFGin 6.119 14.524 ABAminus -117.07, -37.76 -110.06, 107.52 -111.08, 38.44 282.92, 90.71 -87.79, -43.75 in-in in 7.862 Saltbr-in 2.577 HRD-in -71.95, -46.72 76.96, -5.2 in-out-out SNCioo out-out ActLoopNT-out 6.553 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -98.2, -2.7 APE9-dihe-in -71.32, 134.53 APE8-dihe-in -74.4, 64.1 APE8-rot-na 36.74 APE67-dihe-in -65.93, -15.67 -63.14, -27.35 APE12-dist-na 15.602 APE11-dist-na 15.795 APE10-dist-na 10.57 APE9-dist-out 8.4 None None None XRAY 1.645 0.198 0.229 A 321 275 22 0 0 8 [[1116, 1385]] 1.0 8arj Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.2 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 6E0RA Q9UM73 1099 1399 1620.0 HKJ:1500 Type1 Inactive DFGin 5.99 14.13 ABAminus -126.54, 6.88 -146.63, 139.75 -129.52, 23.79 286.55, 86.22 -54.44, -45.81 in-out in 8.291 Saltbr-out 4.491 HRD-in -74.7, -43.96 75.16, -3.83 out-out-none SNCoon out-none ActLoopNT-out 6.491 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -139.14 APE9-dihe-in -62.89, 135.23 APE8-dihe-in -79.57, 61.66 APE8-rot-na 34.01 APE67-dihe-in -70.37, -9.48 -43.47, -41.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.883 APE9-dist-in 7.808 None None None XRAY 2.303 0.241 0.296 A 322 279 22 0 0 11 [[1116, 1385]] 1.0 6e0r Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 6EBWA Q9UM73 1096 1399 1620.0 J3Y:1500 Type1 Inactive DFGin 6.332 14.771 ABAminus -124.53, 13.61 -158.52, 147.01 -134.91, 49.92 284.01, 90.06 -74.0, -48.2 in-out in 7.725 Saltbr-out 5.135 HRD-in -83.27, -44.43 72.92, 3.22 out-out-none SNCoon out-none ActLoopNT-out 7.088 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 149.36 APE8-dihe-in -68.97, 75.32 APE8-rot-na 28.29 APE67-dihe-in -64.76, -14.09 -59.15, -42.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.811 None None None XRAY 2.455 0.246 0.286 A 322 277 24 0 0 14 [[1116, 1385]] 1.0 6ebw Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 7JYRA Q9UM73 1095 1399 1620.0 VTA:1601 Type1 Inactive DFGin 6.037 14.647 ABAminus -117.25, -3.0 -143.43, 138.22 -132.95, 32.31 290.25, 83.3 -65.6, -36.91 in-out in 7.918 Saltbr-out 4.757 HRD-in -74.08, -42.05 82.36, -13.99 out-out-out SNCooo out-out ActLoopNT-out 6.909 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.47, -3.99 APE9-dihe-in -74.12, 138.94 APE8-dihe-in -75.24, 67.71 APE8-rot-na 31.71 APE67-dihe-in -73.48, -9.59 -58.72, -34.79 APE12-dist-na 15.178 APE11-dist-na 15.655 APE10-dist-na 10.5 APE9-dist-out 8.454 None None None XRAY 2.32 0.216 0.247 A 322 287 18 0 0 7 [[1116, 1385]] 1.0 7jyr Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 7JYSA Q9UM73 1095 1399 1620.0 VTD:1601 Type1 Inactive DFGin 5.847 14.421 ABAminus -117.17, -14.0 -132.7, 135.12 -128.93, 36.18 292.83, 86.2 -69.53, -37.99 in-in in 7.962 Saltbr-in 2.539 HRD-in -70.79, -47.81 83.57, -7.04 in-out-out SNCioo out-out ActLoopNT-out 6.954 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -114.43, -7.14 APE9-dihe-in -64.31, 136.8 APE8-dihe-in -71.91, 66.98 APE8-rot-na 26.54 APE67-dihe-in -68.83, -10.73 -59.12, -37.36 APE12-dist-na 15.097 APE11-dist-na 15.496 APE10-dist-na 10.354 APE9-dist-out 8.19 None None None XRAY 2.22 0.216 0.253 A 322 281 24 0 0 7 [[1116, 1385]] 1.0 7jys Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 7JYTA Q9UM73 1095 1399 1620.0 VRM:1502 Type1 Inactive DFGin 5.977 14.46 ABAminus -124.69, -2.73 -143.22, 137.8 -131.88, 32.76 291.21, 85.91 -67.73, -37.01 in-out in 7.924 Saltbr-out 5.327 HRD-in -79.43, -44.52 77.34, -3.4 out-out-out SNCooo out-out ActLoopNT-out 6.823 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -112.03, -10.17 APE9-dihe-in -61.0, 135.32 APE8-dihe-in -73.73, 64.74 APE8-rot-na 29.73 APE67-dihe-in -69.91, -11.24 -57.53, -36.41 APE12-dist-na 15.041 APE11-dist-na 15.528 APE10-dist-na 10.358 APE9-dist-out 8.143 None None None XRAY 2.0 0.209 0.224 A 322 281 24 0 0 7 [[1116, 1385]] 1.0 7jyt Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 2XP2A Q9UM73 1093 1401 1620.0 VGH:9000 Type1 Inactive DFGin 6.01 14.853 ABAminus -116.89, -30.31 -113.6, 135.35 -129.42, 33.32 290.86, 85.52 -68.93, -36.66 in-out in 8.312 Saltbr-out 4.843 HRD-in -70.6, -46.14 82.26, -7.39 out-out-out SNCooo out-out ActLoopNT-out 6.785 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -14.78 APE9-dihe-in -71.8, 131.97 APE8-dihe-in -75.49, 62.54 APE8-rot-na 30.87 APE67-dihe-in -72.66, -13.49 -62.38, -23.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.148 APE9-dist-out 8.257 None None None XRAY 1.9 0.207 0.252 A 327 289 20 0 0 9 [[1116, 1385]] 1.0 2xp2 Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4CCBA Q9UM73 1093 1401 1620.0 OFG:2401 Type1 Inactive DFGin 6.05 14.768 ABAminus -119.22, -9.24 -133.44, 139.2 -130.65, 36.27 292.81, 84.36 -70.77, -32.92 in-in in 7.849 Saltbr-in 2.919 HRD-in -75.15, -47.62 82.69, -9.54 in-out-none SNCion out-none ActLoopNT-out 6.896 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -19.77 APE9-dihe-in -65.32, 136.43 APE8-dihe-in -75.25, 61.07 APE8-rot-na 30.01 APE67-dihe-in -69.24, -12.29 -57.16, -31.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.95 APE9-dist-in 7.908 None None None XRAY 2.03 0.202 0.235 A 327 291 18 0 0 9 [[1116, 1385]] 1.0 4ccb Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4CCUA Q9UM73 1093 1402 1620.0 AWF:1500 Type1 Inactive DFGin 6.02 14.623 ABAminus -118.73, -9.8 -132.17, 139.04 -133.56, 37.48 295.42, 86.35 -74.53, -27.89 in-out in 8.277 Saltbr-out 4.689 HRD-in -77.94, -47.73 82.62, -10.67 out-out-out SNCooo out-out ActLoopNT-out 6.803 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.98, -27.23 APE9-dihe-in -56.62, 135.11 APE8-dihe-in -75.38, 65.75 APE8-rot-na 29.29 APE67-dihe-in -70.29, -14.23 -60.1, -29.45 APE12-dist-na 14.525 APE11-dist-na 15.17 APE10-dist-na 10.028 APE9-dist-in 7.796 None None None XRAY 2.0 0.202 0.233 A 327 293 17 0 0 6 [[1116, 1385]] 1.0 4ccu Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4CLIA Q9UM73 1093 1401 1620.0 5P8:2401 Type1 Inactive DFGin 6.104 14.664 ABAminus -126.26, -5.06 -135.36, 136.5 -131.98, 39.01 293.42, 86.05 -79.91, -26.98 in-out in 8.304 Saltbr-out 4.519 HRD-in -75.26, -46.3 81.47, -9.07 out-out-out SNCooo out-out ActLoopNT-out 6.844 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.34, -12.93 APE9-dihe-in -62.11, 137.41 APE8-dihe-in -77.3, 59.87 APE8-rot-na 29.14 APE67-dihe-in -74.79, -11.71 -58.14, -27.0 APE12-dist-na 14.664 APE11-dist-na 14.982 APE10-dist-na 10.003 APE9-dist-in 7.829 None None None XRAY 2.05 0.199 0.245 A 327 295 14 0 0 6 [[1116, 1385]] 1.0 4cli Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4CMOA Q9UM73 1093 1402 1620.0 YPW:2402 Type1 Inactive DFGin 6.179 14.729 ABAminus -120.95, -9.17 -132.13, 138.79 -131.64, 32.19 292.59, 86.4 -67.48, -36.83 in-out in 8.108 Saltbr-out 5.099 HRD-in -74.69, -45.72 80.53, -9.82 out-out-out SNCooo out-out ActLoopNT-out 6.894 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.18, -16.6 APE9-dihe-in -61.82, 137.9 APE8-dihe-in -75.79, 58.08 APE8-rot-na 29.65 APE67-dihe-in -70.92, -9.19 -55.73, -32.13 APE12-dist-na 14.61 APE11-dist-na 14.902 APE10-dist-na 9.821 APE9-dist-in 7.831 None None None XRAY 2.05 0.199 0.245 A 327 296 14 0 0 6 [[1116, 1385]] 1.0 4cmo Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4CMTA Q9UM73 1093 1401 1620.0 GWH:2401 Type1 Inactive DFGin 6.212 14.83 ABAminus -123.22, -5.39 -133.47, 138.97 -132.82, 32.21 291.71, 85.66 -66.83, -37.56 in-in in 7.927 Saltbr-in 2.622 HRD-in -73.35, -43.01 78.17, -7.26 in-out-none SNCion out-none ActLoopNT-out 6.913 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 3.2 APE9-dihe-in -71.77, 138.91 APE8-dihe-in -76.34, 59.3 APE8-rot-na 30.92 APE67-dihe-in -69.85, -8.04 -57.32, -34.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.793 APE9-dist-in 7.876 None None None XRAY 1.73 0.214 0.248 A 327 288 21 0 0 9 [[1116, 1385]] 1.0 4cmt Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4CMUA Q9UM73 1093 1401 1620.0 IV7:2401 Type1 Inactive DFGin 6.225 14.848 ABAminus -119.02, -15.67 -129.52, 137.46 -129.87, 35.57 292.32, 83.85 -72.08, -34.25 in-out in 8.268 Saltbr-out 5.052 HRD-in -73.08, -46.65 81.42, -8.55 out-out-out SNCooo out-out ActLoopNT-out 6.944 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -98.74, -12.22 APE9-dihe-in -65.64, 137.39 APE8-dihe-in -75.72, 59.54 APE8-rot-na 29.91 APE67-dihe-in -71.19, -9.41 -57.38, -31.15 APE12-dist-na 14.669 APE11-dist-na 14.871 APE10-dist-na 9.865 APE9-dist-in 7.894 None None None XRAY 1.8 0.206 0.227 A 327 295 14 0 0 6 [[1116, 1385]] 1.0 4cmu Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4CNHA Q9UM73 1094 1402 1620.0 3U9:2402 Type1 Inactive DFGin 6.328 15.046 ABAminus -121.41, -13.5 -134.76, 134.27 -127.13, 24.83 291.86, 80.94 -58.37, -37.06 in-out in 7.905 Saltbr-out 4.916 HRD-in -72.36, -47.54 81.36, -5.81 out-out-none SNCoon out-none ActLoopNT-out 7.025 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 36.87 APE9-dihe-in -64.44, 124.84 APE8-dihe-in -71.68, 78.76 APE8-rot-na 25.36 APE67-dihe-in -71.29, -8.43 -50.25, -44.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.445 APE9-dist-in 6.811 None None None XRAY 1.9 0.206 0.25 A 327 286 23 0 0 10 [[1116, 1385]] 1.0 4cnh Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4CTBA Q9UM73 1093 1402 1620.0 KVC:2402 Type1 Inactive DFGin 6.216 14.849 ABAminus -119.67, -9.24 -135.77, 135.53 -130.14, 34.99 293.83, 84.83 -68.92, -36.75 in-in in 7.801 Saltbr-in 3.083 HRD-in -73.33, -46.07 82.91, -9.21 in-out-out SNCioo out-out ActLoopNT-out 6.941 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.19, -13.84 APE9-dihe-in -65.2, 138.92 APE8-dihe-in -74.78, 60.38 APE8-rot-na 30.11 APE67-dihe-in -72.32, -8.28 -56.62, -34.41 APE12-dist-na 14.636 APE11-dist-na 14.997 APE10-dist-na 9.965 APE9-dist-out 8.001 None None None XRAY 1.79 0.21 0.247 A 327 293 17 0 0 6 [[1116, 1385]] 1.0 4ctb Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4CTCA Q9UM73 1094 1402 1620.0 J99:2402 Type1 Inactive DFGin 6.087 14.436 ABAminus -113.76, -13.97 -127.87, 134.88 -130.21, 34.39 296.92, 88.54 -69.58, -32.9 in-out in 7.818 Saltbr-out 4.663 HRD-in -68.52, -47.86 79.55, -14.18 out-out-out SNCooo out-out ActLoopNT-out 6.628 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.25, -22.21 APE9-dihe-in -63.2, 137.35 APE8-dihe-in -83.4, 68.98 APE8-rot-na 27.6 APE67-dihe-in -69.91, -15.73 -58.12, -29.13 APE12-dist-na 14.935 APE11-dist-na 15.258 APE10-dist-na 10.203 APE9-dist-in 7.824 None None None XRAY 2.03 0.194 0.216 A 327 289 20 0 0 8 [[1116, 1385]] 1.0 4ctc Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 5KZ0A Q9UM73 1093 1401 1620.0 6YL:1501 Type1 Inactive DFGin 5.922 14.406 ABAminus -133.15, -11.67 -127.06, 138.04 -132.87, 29.16 292.21, 94.94 -79.99, -2.4 in-out in 7.919 Saltbr-out 4.084 HRD-in -74.2, -39.11 78.61, -15.85 out-out-out SNCooo out-out ActLoopNT-out 6.835 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -92.46, -46.15 APE9-dihe-in -45.76, 137.83 APE8-dihe-in -84.92, 73.38 APE8-rot-na 33.7 APE67-dihe-in -73.49, -11.11 -70.16, -20.71 APE12-dist-na 15.231 APE11-dist-na 15.196 APE10-dist-na 10.044 APE9-dist-in 7.788 None None None XRAY 2.3 0.18 0.269 A 327 293 16 0 0 8 [[1116, 1385]] 1.0 5kz0 Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 7R7KA Q9UM73 1094 1400 1620.0 25J:1501 Type1 Inactive DFGin 6.296 14.799 ABAminus -117.03, -7.91 -132.86, 139.73 -133.05, 30.6 293.43, 91.77 -61.89, -44.97 in-out in 7.758 Saltbr-out 4.764 HRD-in -63.52, -48.31 78.95, -7.31 out-out-out SNCooo out-out ActLoopNT-out 6.906 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.56, -4.43 APE9-dihe-in -73.03, 141.44 APE8-dihe-in -80.52, 63.08 APE8-rot-na 29.68 APE67-dihe-in -66.55, -12.77 -43.97, -45.25 APE12-dist-na 14.143 APE11-dist-na 14.927 APE10-dist-na 9.807 APE9-dist-in 7.912 None None None XRAY 1.831 0.195 0.221 A 327 290 17 0 0 6 [[1116, 1385]] 1.0 7r7k Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 7R7RA Q9UM73 1093 1401 1620.0 AWJ:1501 Type1 Inactive DFGin 6.122 14.694 ABAminus -114.04, -10.1 -130.71, 138.84 -131.21, 32.52 294.04, 89.2 -62.61, -42.67 in-out in 8.025 Saltbr-out 4.75 HRD-in -66.43, -50.15 80.96, -9.24 out-out-out SNCooo out-out ActLoopNT-out 6.883 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -105.96, -19.38 APE9-dihe-in -67.0, 138.74 APE8-dihe-in -79.51, 69.3 APE8-rot-na 29.25 APE67-dihe-in -68.73, -13.21 -57.11, -32.66 APE12-dist-na 14.453 APE11-dist-na 14.973 APE10-dist-na 9.85 APE9-dist-in 7.728 None None None XRAY 1.935 0.193 0.227 A 327 291 18 0 0 7 [[1116, 1385]] 1.0 7r7r Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4FNZA Q9UM73 1093 1402 1620.0 NZF:1501 Type1 Inactive DFGin 5.291 12.8 ABAminus -135.46, 12.02 -152.76, 153.63 -83.97, -38.55 283.31, 122.35 73.66, 999.0 in-in in 8.5 Saltbr-in 2.812 HRD-in -72.66, -49.3 78.9, -9.45 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.65, -24.93 APE9-dihe-in -50.61, 132.71 APE8-dihe-in -79.34, 69.48 APE8-rot-na 27.73 APE67-dihe-in -74.42, -13.21 -56.44, -36.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.83 C1097S None None XRAY 2.6 0.202 0.261 A 327 287 23 0 0 15 [[1116, 1385]] 1.0 4fnz Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 5IUIA Q9UM73 1089 1400 1620.0 45Q:1501 Type1 Inactive DFGin 6.097 15.067 ABAminus -115.96, -40.57 -98.03, 131.36 -128.94, 30.02 290.16, 88.83 -67.06, -40.42 in-in in 8.173 Saltbr-in 2.935 HRD-in -74.44, -37.49 70.23, -3.09 in-out-out SNCioo out-out ActLoopNT-out 7.049 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -106.21, -6.36 APE9-dihe-in -64.31, 145.1 APE8-dihe-in -79.79, 58.82 APE8-rot-na 31.57 APE67-dihe-in -70.65, -5.92 -44.41, -46.15 APE12-dist-na 14.442 APE11-dist-na 15.056 APE10-dist-na 10.039 APE9-dist-out 8.117 C1097S None None XRAY 1.88 0.181 0.205 A 327 303 9 0 0 5 [[1116, 1385]] 1.0 5iui Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4FODA Q9UM73 1085 1405 1620.0 0UV:1501 Type1 Inactive DFGin 6.303 14.942 ABAminus -126.17, 8.88 -148.68, 139.13 -133.76, 30.42 294.7, 92.17 -67.04, -41.19 in-in in 7.487 Saltbr-in 2.605 HRD-in -73.82, -48.62 76.13, -0.28 in-out-out SNCioo out-out ActLoopNT-out 7.025 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -105.69, -7.83 APE9-dihe-in -60.03, 145.3 APE8-dihe-in -82.29, 62.32 APE8-rot-na 33.22 APE67-dihe-in -70.05, -10.83 -47.36, -42.53 APE12-dist-na 11.937 APE11-dist-na 15.069 APE10-dist-na 10.011 APE9-dist-in 7.843 C1097S None None XRAY 2.0 0.18 0.221 A 333 308 13 0 0 7 [[1116, 1385]] 1.0 4fod Homo sapiens TYR_ALK_HUMAN TYR 1.5e-90 309.0 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 3AOXA Q9UM73 1086 1401 1620.0 EMH:901 Type1 Inactive DFGin 6.407 14.944 ABAminus -137.07, 23.28 -158.41, 139.16 -133.43, 27.21 291.39, 95.08 -65.65, -43.18 in-in in 7.657 Saltbr-in 2.594 HRD-in -71.98, -46.85 79.15, -6.33 in-out-out SNCioo out-out ActLoopNT-out 6.955 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -95.63, -6.24 APE9-dihe-in -65.1, 144.04 APE8-dihe-in -84.44, 65.15 APE8-rot-na 34.19 APE67-dihe-in -68.33, -10.93 -51.94, -40.89 APE12-dist-na 11.753 APE11-dist-na 14.962 APE10-dist-na 9.921 APE9-dist-in 7.992 None None None XRAY 1.75 0.17 0.206 A 344 298 18 0 0 7 [[1116, 1385]] 1.0 3aox Homo sapiens TYR_ALK_HUMAN TYR 1.7e-90 308.8 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 5A9UA Q9UM73 1093 1402 1620.0 5P8:2402 Type1 Inactive DFGin 6.068 14.657 ABAminus -124.48, -3.05 -136.25, 135.66 -131.11, 34.63 291.44, 81.89 -72.61, -25.01 in-out in 8.133 Saltbr-out 3.838 HRD-in -74.43, -46.73 80.61, -9.35 out-out-out SNCooo out-out ActLoopNT-out 6.844 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.6, -12.67 APE9-dihe-in -61.75, 137.74 APE8-dihe-in -78.53, 58.82 APE8-rot-na 30.41 APE67-dihe-in -71.12, -10.64 -57.9, -28.42 APE12-dist-na 14.791 APE11-dist-na 15.374 APE10-dist-na 10.294 APE9-dist-out 8.143 C1156Y None None XRAY 1.6 0.216 0.258 A 327 293 17 0 0 6 [[1116, 1385]] 1.0 5a9u Homo sapiens TYR_ALK_HUMAN TYR 1.9e-90 308.6 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 5AACA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 6.049 14.948 ABAminus -115.19, -31.77 -111.83, 134.22 -128.43, 30.25 290.07, 81.16 -65.53, -32.88 in-out in 8.27 Saltbr-out 4.608 HRD-in -73.86, -46.4 82.42, -9.17 out-out-out SNCooo out-out ActLoopNT-out 6.925 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.47, -8.93 APE9-dihe-in -64.75, 135.46 APE8-dihe-in -76.69, 59.35 APE8-rot-na 30.37 APE67-dihe-in -71.48, -11.11 -59.44, -28.8 APE12-dist-na 14.745 APE11-dist-na 15.323 APE10-dist-na 10.293 APE9-dist-out 8.192 C1156Y None None XRAY 1.7 0.208 0.232 A 327 293 17 0 0 6 [[1116, 1385]] 1.0 5aac Homo sapiens TYR_ALK_HUMAN TYR 1.9e-90 308.6 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 7BTTA Q9UM73 1093 1401 1620.0 F8R:1501 Type1 Inactive DFGin 6.156 14.786 ABAminus -122.03, -17.95 -119.49, 138.11 -134.22, 32.1 293.32, 88.16 -75.16, -36.17 in-in in 7.593 Saltbr-in 2.857 HRD-in -69.97, -43.61 74.45, -5.72 in-out-out SNCioo out-out ActLoopNT-out 7.027 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -102.06, -5.75 APE9-dihe-in -67.85, 139.87 APE8-dihe-in -78.72, 64.66 APE8-rot-na 32.81 APE67-dihe-in -71.63, -7.08 -50.37, -43.62 APE12-dist-na 14.563 APE11-dist-na 14.908 APE10-dist-na 9.821 APE9-dist-out 8.088 None None None XRAY 1.86 0.188 0.209 A 320 304 5 0 0 0 [[1116, 1385]] 1.0 7btt Homo sapiens TYR_ALK_HUMAN TYR 3.9e-90 307.6 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4FOBA Q9UM73 1093 1402 1620.0 0US:1501 Type1 Inactive DFGin 6.203 14.608 ABAminus -121.93, -5.87 -135.31, 135.62 -128.54, 34.16 296.11, 87.18 -69.77, -38.85 in-in in 7.861 Saltbr-in 2.609 HRD-in -75.01, -47.81 80.74, -11.97 in-out-out SNCioo out-out ActLoopNT-out 6.963 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -99.67, -8.45 APE9-dihe-in -60.62, 141.15 APE8-dihe-in -80.22, 63.12 APE8-rot-na 30.66 APE67-dihe-in -69.42, -9.11 -51.4, -43.54 APE12-dist-na 14.346 APE11-dist-na 14.725 APE10-dist-na 9.646 APE9-dist-in 7.854 C1097S None None XRAY 1.9 0.203 0.255 A 353 295 15 0 0 6 [[1116, 1385]] 1.0 4fob Homo sapiens TYR_ALK_HUMAN TYR 1.8e-90 308.8 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4FOCA Q9UM73 1093 1402 1620.0 0UU:1501 Type1 Inactive DFGin 6.324 14.569 ABAminus -123.54, -7.23 -132.63, 134.75 -129.46, 36.57 293.68, 84.81 -70.2, -37.62 in-in in 7.786 Saltbr-in 3.101 HRD-in -69.96, -48.47 78.5, -3.5 in-out-out SNCioo out-out ActLoopNT-out 6.988 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.01, -12.7 APE9-dihe-in -61.61, 144.79 APE8-dihe-in -84.7, 68.48 APE8-rot-na 34.22 APE67-dihe-in -73.32, -8.77 -52.28, -39.37 APE12-dist-na 12.056 APE11-dist-na 15.029 APE10-dist-na 9.917 APE9-dist-in 7.765 C1097S None None XRAY 1.7 0.191 0.225 A 353 296 14 0 0 8 [[1116, 1385]] 1.0 4foc Homo sapiens TYR_ALK_HUMAN TYR 1.8e-90 308.8 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4Z55A Q9UM73 1093 1399 1620.0 4LO:1503 Type1 Inactive DFGin 6.253 14.635 ABAminus -123.6, 13.8 -145.92, 137.93 -133.07, 27.38 295.45, 90.97 -57.61, -49.96 in-in in 7.456 Saltbr-in 2.784 HRD-in -65.39, -47.79 76.59, -11.13 in-out-out SNCioo out-out ActLoopNT-out 6.872 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.75, -10.47 APE9-dihe-in -67.58, 140.18 APE8-dihe-in -79.19, 59.38 APE8-rot-na 31.88 APE67-dihe-in -66.53, -10.05 -40.3, -48.22 APE12-dist-na 14.877 APE11-dist-na 15.159 APE10-dist-na 10.085 APE9-dist-out 8.072 S1281G None None XRAY 1.55 0.185 0.208 A 339 294 13 0 0 1 [[1116, 1385]] 1.0 4z55 Homo sapiens TYR_ALK_HUMAN TYR 4.7e-90 307.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 3LCSA Q9UM73 1096 1399 1620.0 STU:1 Type1 Inactive DFGin 6.33 14.912 ABAminus -115.64, -37.74 -102.74, 114.2 -112.42, 20.01 289.12, 86.66 -56.01, -38.26 in-in in 7.78 Saltbr-in 2.662 HRD-in -69.52, -44.32 78.89, -12.54 in-out-out SNCioo out-out ActLoopNT-out 6.794 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.07, -13.05 APE9-dihe-in -64.04, 139.47 APE8-dihe-in -80.51, 60.39 APE8-rot-na 31.54 APE67-dihe-in -67.01, -14.6 -60.37, -27.86 APE12-dist-na 15.308 APE11-dist-na 15.569 APE10-dist-na 10.539 APE9-dist-out 8.296 S1281G None None XRAY 1.95 0.196 0.229 A 344 304 0 0 0 0 [[1116, 1385]] 1.0 3lcs Homo sapiens TYR_ALK_HUMAN TYR 5e-90 307.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4MKCA Q9UM73 1093 1401 1620.0 4MK:1503 Type1 Inactive DFGin 6.142 14.787 ABAminus -119.13, 7.31 -142.69, 137.29 -134.51, 29.61 298.97, 84.4 -59.55, -42.66 in-in in 7.656 Saltbr-in 2.864 HRD-in -66.46, -45.49 70.41, -4.89 in-out-out SNCioo out-out ActLoopNT-out 6.896 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.61, -14.66 APE9-dihe-in -63.04, 142.03 APE8-dihe-in -82.73, 64.43 APE8-rot-na 33.65 APE67-dihe-in -65.02, -10.82 -49.18, -45.64 APE12-dist-na 14.918 APE11-dist-na 15.251 APE10-dist-na 10.205 APE9-dist-out 8.118 S1281G None None XRAY 2.01 0.173 0.218 A 367 303 6 0 0 0 [[1116, 1385]] 1.0 4mkc Homo sapiens TYR_ALK_HUMAN TYR 6.2e-90 307.0 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 9GBEA Q9UM73 1086 1401 1620.0 A1IJ8:1501 Type1 Inactive DFGin 6.226 14.835 ABAminus -118.03, -13.57 -139.47, 137.54 -132.04, 28.84 289.39, 90.38 -67.89, -35.38 in-in in 7.85 Saltbr-in 2.71 HRD-in -70.68, -49.03 81.56, -8.45 in-out-out SNCioo out-out ActLoopNT-out 6.913 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.96, -12.0 APE9-dihe-in -66.08, 139.0 APE8-dihe-in -79.17, 64.92 APE8-rot-na 34.36 APE67-dihe-in -67.16, -14.31 -60.07, -32.34 APE12-dist-na 14.167 APE11-dist-na 15.029 APE10-dist-na 9.892 APE9-dist-out 8.07 L1196M,G1202R None None XRAY 1.58 0.186 0.224 A 344 304 12 0 0 6 [[1116, 1385]] 1.0 9gbe Homo sapiens TYR_ALK_HUMAN TYR 3.3e-89 304.6 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4CNHB Q9UM73 1093 1401 1620.0 3U9:2401,3U9:2402 Type1,Allosteric Inactive DFGin 4.339 12.327 ABAminus -115.59, -14.06 -164.87, 163.73 -86.41, -10.43 302.46, 115.44 53.37, -130.64 in-in in 8.072 Saltbr-in 2.629 HRD-in -84.33, -49.79 83.6, -11.29 in-out-out SNCioo out-out ActLoopNT-out 8.549 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -91.6, -17.34 APE9-dihe-in -73.51, 138.4 APE8-dihe-in -77.48, 68.43 APE8-rot-na 27.84 APE67-dihe-in -66.22, -13.37 -69.94, -19.9 APE12-dist-na 12.784 APE11-dist-na 13.464 APE10-dist-na 8.385 APE9-dist-out 8.684 None None None XRAY 1.9 0.206 0.25 B 327 294 15 0 0 5 [[1116, 1385]] 1.0 4cnh Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4JOAA Q9UM73 1107 1398 1620.0 3DK:1501 Type1.5_Front Inactive DFGin 5.651 15.18 ABAminus -99.28, -25.44 -116.97, 136.23 -132.09, 28.46 289.09, 82.31 -66.18, -40.48 in-out in 8.532 Saltbr-out 7.323 HRD-in -79.35, -45.13 67.79, 9.59 out-out-out SNCooo out-out ActLoopNT-out 6.633 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -75.97, -11.03 APE9-dihe-in -75.81, 135.85 APE8-dihe-in -79.69, 75.84 APE8-rot-na 32.08 APE67-dihe-in -70.53, -20.07 -69.09, -33.02 APE12-dist-na 999.0 APE11-dist-na 15.099 APE10-dist-na 10.28 APE9-dist-out 8.098 S1281G None None XRAY 2.7 0.253 0.29 A 344 251 41 0 0 9 [[1116, 1385]] 1.0 4joa Homo sapiens TYR_ALK_HUMAN TYR 5e-90 307.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 2YJRA Q9UM73 1101 1402 1620.0 No_ligand No_ligand Inactive DFGin 6.309 14.703 None -109.22, -156.6 -24.57, 131.48 -106.45, 12.37 294.91, 66.22 -54.96, -56.35 in-in in 7.943 Saltbr-in 3.124 HRD-in -78.17, -44.51 78.03, -12.49 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -91.23, -22.26 APE9-dihe-in -61.19, 130.79 APE8-dihe-in -74.37, 65.56 APE8-rot-na 28.22 APE67-dihe-in -67.2, -14.23 -60.39, -32.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.855 F1174L None None XRAY 1.9 0.221 0.281 A 342 281 21 0 0 14 [[1116, 1385]] 1.0 2yjr Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.2 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 6EDLA Q9UM73 1093 1399 1620.0 J4M:1500 Type1 Inactive DFGin 5.742 13.999 None -126.77, 7.53 -146.28, 139.77 -129.2, 999.0 286.43, 88.97 999.0, 999.0 in-in in 8.043 Saltbr-in 3.203 HRD-in -75.33, -45.54 75.3, -3.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -90.79, -15.28 APE9-dihe-in -62.49, 138.06 APE8-dihe-in -76.58, 62.31 APE8-rot-na 33.87 APE67-dihe-in -71.34, -10.1 -42.44, -41.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.115 None None None XRAY 2.799 0.231 0.282 A 322 282 25 0 0 16 [[1116, 1385]] 1.0 6edl Homo sapiens TYR_ALK_HUMAN TYR 1.3e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 5IMXA Q9UM73 1109 1400 1620.0 CZ4:1501 Type1 Inactive DFGin 5.034 14.449 None -109.53, -14.09 -148.27, 147.07 -105.7, 146.52 283.91, 86.87 -67.35, -107.72 in-in in 8.028 Saltbr-in 2.504 HRD-in -65.65, -55.77 80.57, -2.35 in-out-out SNCioo out-out ActLoopNT-out 7.558 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -82.05, -3.8 APE9-dihe-in -82.72, 146.31 APE8-dihe-in -87.12, 68.37 APE8-rot-na 16.28 APE67-dihe-in -69.01, -16.06 -50.43, -36.09 APE12-dist-na 10.904 APE11-dist-na 15.562 APE10-dist-na 10.632 APE9-dist-in 7.972 None None None XRAY 2.12 0.213 0.259 A 327 266 26 0 0 10 [[1116, 1385]] 1.0 5imx Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4DCEA Q9UM73 1093 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.63 13.823 None -137.27, 16.47 -161.52, 152.14 -94.73, 164.26 291.72, 122.64 -76.17, 999.0 in-in in 8.482 Saltbr-in 2.883 HRD-in -75.4, -48.78 85.77, -10.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.83, -20.84 APE9-dihe-in -55.51, 136.7 APE8-dihe-in -77.28, 70.08 APE8-rot-na 28.6 APE67-dihe-in -68.31, -8.92 -56.77, -41.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.974 C1097S None None XRAY 2.03 0.211 0.256 A 333 288 22 0 0 14 [[1116, 1385]] 1.0 4dce Homo sapiens TYR_ALK_HUMAN TYR 1.5e-90 309.0 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4DCEB Q9UM73 1094 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.747 13.628 None -141.04, 18.73 -165.26, 150.02 -96.5, 167.37 286.77, 120.17 -70.38, 999.0 in-in in 8.563 Saltbr-in 2.99 HRD-in -72.56, -48.26 83.87, -14.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.41, -12.56 APE9-dihe-in -59.98, 136.0 APE8-dihe-in -80.48, 64.18 APE8-rot-na 31.8 APE67-dihe-in -66.1, -14.3 -52.07, -41.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.713 C1097S None None XRAY 2.03 0.211 0.256 B 333 284 25 0 0 15 [[1116, 1385]] 1.0 4dce Homo sapiens TYR_ALK_HUMAN TYR 1.5e-90 309.0 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 5IUGA Q9UM73 1093 1404 1620.0 729:1501 Type2 Inactive DFGout 14.153 9.999 BBAminus -131.11, -160.99 -160.87, 113.54 -82.67, -13.49 278.51, 100.05 82.21, 14.97 in-in in 7.669 Saltbr-in 3.074 HRD-in -68.79, -47.96 74.11, -0.87 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.37, -10.99 APE9-dihe-in -66.27, 131.08 APE8-dihe-in -74.93, 62.41 APE8-rot-na 32.11 APE67-dihe-in -72.28, -10.91 -51.72, -32.16 APE12-dist-na 14.999 APE11-dist-na 12.817 APE10-dist-na 7.9 APE9-dist-out 8.42 C1097S None None XRAY 1.93 0.184 0.211 A 327 285 27 0 0 12 [[1116, 1385]] 1.0 5iug Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 5IUHA Q9UM73 1093 1404 1620.0 34Y:1501 Type2 Inactive DFGout 14.232 10.118 BBAminus -138.56, -161.58 -159.14, 110.88 -77.24, -9.47 279.89, 100.17 78.06, 14.37 in-in in 7.62 Saltbr-in 2.988 HRD-in -72.63, -47.58 76.22, -3.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -97.17, -17.0 APE9-dihe-in -66.13, 131.14 APE8-dihe-in -77.12, 65.41 APE8-rot-na 31.95 APE67-dihe-in -67.53, -10.9 -52.9, -35.57 APE12-dist-na 14.94 APE11-dist-na 12.961 APE10-dist-na 8.224 APE9-dist-out 8.544 C1097S None None XRAY 2.1 0.183 0.221 A 327 285 27 0 0 13 [[1116, 1385]] 1.0 5iuh Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
ALK_HUMAN 4FNYA Q9UM73 1103 1404 1620.0 I3K:1501 Type2 Inactive DFGout 14.184 10.088 None -127.21, -165.1 -161.64, 122.7 -96.04, 999.0 291.91, 90.85 999.0, 999.0 in-in in 7.899 Saltbr-in 2.528 HRD-in -68.56, -48.94 76.07, 1.7 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.3, -24.9 APE9-dihe-in -67.06, 137.93 APE8-dihe-in -72.43, 66.19 APE8-rot-na 27.5 APE67-dihe-in -66.24, -16.71 -48.34, -39.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.214 C1097S,R1275Q None None XRAY 2.45 0.196 0.252 A 327 273 29 0 0 16 [[1116, 1385]] 1.0 4fny Homo sapiens TYR_ALK_HUMAN TYR 3.6e-90 307.7 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor

TYR_ALK (ALK tyrosine kinase receptor)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name