Protein kinases in complex with B96 (Doramapimod)

Total number of genes: 7
Total number of chains: 12
Spatial Dihedral Chains Representative
DFGout BBAminus 6 4JVGA
DFGout None 6 3NPCA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
CMGC MAPK11 MK11_HUMAN Mitogen-activated protein kinase 11 8YGWA 3.301 Inactive DFGout None in-out none-out B96 Type2
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 5N66A 2.4 Inactive DFGout None in-in none-out BW1 B96 Allosteric Type2
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 1KV2A 2.8 Inactive DFGout None in-in none-none B96 Type2
CMGC MAPK9 MK09_HUMAN Mitogen-activated protein kinase 9 3NPCA 2.35 Inactive DFGout None in-in out-out B96 Type2
CMGC MAPK9 MK09_HUMAN Mitogen-activated protein kinase 9 3NPCB 2.35 Inactive DFGout None in-in out-out B96 Type2
STE STK10 STK10_HUMAN Serine/threonine-protein kinase 10 6GTTA 2.25 Inactive DFGout BBAminus in-in none-none B96 Type2
TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf 4JVGA 3.09 Inactive DFGout BBAminus in-in out-none B96 Type2
TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf 4JVGB 3.09 Inactive DFGout BBAminus in-in out-none B96 Type2
TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf 4JVGC 3.09 Inactive DFGout BBAminus in-in none-none B96 Type2
TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf 4JVGD 3.09 Inactive DFGout BBAminus in-in out-none B96 Type2
TYR EPHA3 EPHA3_HUMAN Ephrin type-A receptor 3 4TWNA 1.706 Inactive DFGout None in-in out-in B96 Type2
TYR PTK2B FAK2_HUMAN Protein-tyrosine kinase 2-beta 3FZSA 1.75 Inactive DFGout BBAminus in-in none-in B96 Type2

Protein kinases in complex with B96

Total number of genes: 7
Total number of chains: 12
Spatial Dihedral Chains Representative
DFGout BBAminus 6 4JVGA
DFGout None 6 3NPCA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens CMGC MAPK11 MK11_HUMAN Mitogen-activated protein kinase 11 8YGWA 3.301 Inactive DFGout None in-out none-out B96 Type2
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 5N66A 2.4 Inactive DFGout None in-in none-out BW1 B96 Allosteric Type2
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 1KV2A 2.8 Inactive DFGout None in-in none-none B96 Type2
Homo sapiens CMGC MAPK9 MK09_HUMAN Mitogen-activated protein kinase 9 3NPCA 2.35 Inactive DFGout None in-in out-out B96 Type2
Homo sapiens CMGC MAPK9 MK09_HUMAN Mitogen-activated protein kinase 9 3NPCB 2.35 Inactive DFGout None in-in out-out B96 Type2
Homo sapiens STE STK10 STK10_HUMAN Serine/threonine-protein kinase 10 6GTTA 2.25 Inactive DFGout BBAminus in-in none-none B96 Type2
Homo sapiens TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf 4JVGA 3.09 Inactive DFGout BBAminus in-in out-none B96 Type2
Homo sapiens TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf 4JVGB 3.09 Inactive DFGout BBAminus in-in out-none B96 Type2
Homo sapiens TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf 4JVGC 3.09 Inactive DFGout BBAminus in-in none-none B96 Type2
Homo sapiens TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf 4JVGD 3.09 Inactive DFGout BBAminus in-in out-none B96 Type2
Homo sapiens TYR EPHA3 EPHA3_HUMAN Ephrin type-A receptor 3 4TWNA 1.706 Inactive DFGout None in-in out-in B96 Type2
Homo sapiens TYR PTK2B FAK2_HUMAN Protein-tyrosine kinase 2-beta 3FZSA 1.75 Inactive DFGout BBAminus in-in none-in B96 Type2

Protein kinases in complex with B96

Total number of genes: 0
Total number of chains: 0
Spatial Dihedral Chains Representative
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type