PTK2B (Protein-tyrosine kinase 2-beta)

Group: TYR
Uniprot: FAK2_HUMAN
Domain boundary: 425 - 681


Total number of chains: 15
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-Q14289-K1A
DFGin None 5 3CC6A
DFGout BBAminus 2 4H1MA
DFGout None 6 4H1JA
None None 1 3H3CA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q14289-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 417 - 689 None None 0
3FZOA 2.2 Inactive DFGin None in-out out-out No_ligand No_ligand 420 - 691 None None 10
8YGXA 2.0 Inactive DFGin None in-out none-out No_ligand No_ligand 420 - 691 None None 17
3CC6A 1.6 Inactive DFGin None in-in out-out No_ligand No_ligand 415 - 692 None None 9
8XOXA 1.9 Inactive DFGin None in-out none-out YAM Type1 417 - 692 None None 15
5TOBA 2.117 Inactive DFGin None in-none none-none YAM Type1 420 - 690 None None 18
3FZSA 1.75 Inactive DFGout BBAminus in-in none-in B96 Type2 420 - 690 None None 17
4H1MA 1.99 Inactive DFGout BBAminus in-in none-in 0YJ Type2 420 - 690 None None 15
3ET7A 2.7 Inactive DFGout None in-in out-in 349 Type1 419 - 691 None None 12
3FZPA 2.1 Inactive DFGout None in-out none-in AGS Type1 419 - 692 None None 15
3FZRA 2.7 Inactive DFGout None in-in out-in 3JZ Type1 419 - 691 None None 12
5TO8A 1.985 Inactive DFGout None in-none out-none 7FM Type1 420 - 691 None None 16
3FZTA 1.95 Inactive DFGout None in-in out-in 4JZ Type2 420 - 690 None None 12
4H1JA 2.0 Inactive DFGout None in-in out-in 0YH Type2 419 - 690 None None 9
3H3CA 2.0 Inactive None None in-out none-in P1E Type1 416 - 692 None None 14

PTK2B (Protein-tyrosine kinase 2-beta)

Group: TYR
Total number of chains: 15
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-Q14289-K1A
DFGin None 5 3CC6A
DFGout BBAminus 2 4H1MA
DFGout None 6 4H1JA
None None 1 3H3CA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens FAK2_HUMAN AF-Q14289-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 417 - 689 None None 0
Homo sapiens FAK2_HUMAN 3FZOA 2.2 Inactive DFGin None in-out out-out No_ligand No_ligand 420 - 691 None None 10
Homo sapiens FAK2_HUMAN 8YGXA 2.0 Inactive DFGin None in-out none-out No_ligand No_ligand 420 - 691 None None 17
Homo sapiens FAK2_HUMAN 3CC6A 1.6 Inactive DFGin None in-in out-out No_ligand No_ligand 415 - 692 None None 9
Homo sapiens FAK2_HUMAN 8XOXA 1.9 Inactive DFGin None in-out none-out YAM Type1 417 - 692 None None 15
Homo sapiens FAK2_HUMAN 5TOBA 2.117 Inactive DFGin None in-none none-none YAM Type1 420 - 690 None None 18
Homo sapiens FAK2_HUMAN 3FZSA 1.75 Inactive DFGout BBAminus in-in none-in B96 Type2 420 - 690 None None 17
Homo sapiens FAK2_HUMAN 4H1MA 1.99 Inactive DFGout BBAminus in-in none-in 0YJ Type2 420 - 690 None None 15
Homo sapiens FAK2_HUMAN 3ET7A 2.7 Inactive DFGout None in-in out-in 349 Type1 419 - 691 None None 12
Homo sapiens FAK2_HUMAN 3FZPA 2.1 Inactive DFGout None in-out none-in AGS Type1 419 - 692 None None 15
Homo sapiens FAK2_HUMAN 3FZRA 2.7 Inactive DFGout None in-in out-in 3JZ Type1 419 - 691 None None 12
Homo sapiens FAK2_HUMAN 5TO8A 1.985 Inactive DFGout None in-none out-none 7FM Type1 420 - 691 None None 16
Homo sapiens FAK2_HUMAN 3FZTA 1.95 Inactive DFGout None in-in out-in 4JZ Type2 420 - 690 None None 12
Homo sapiens FAK2_HUMAN 4H1JA 2.0 Inactive DFGout None in-in out-in 0YH Type2 419 - 690 None None 9
Homo sapiens FAK2_HUMAN 3H3CA 2.0 Inactive None None in-out none-in P1E Type1 416 - 692 None None 14

PTK2B (Protein-tyrosine kinase 2-beta)

No non-human structures known.