EPHA3 (Ephrin type-A receptor 3)

Group: TYR
Uniprot: EPHA3_HUMAN
Domain boundary: 621 - 880


Total number of chains: 28
Spatial Dihedral Chains Representative
DFGin BLAminus 19 AF-P29320-K1A
DFGin None 6 2QODA
DFGout BBAminus 1 3DZQA
DFGout None 2 4TWNA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P29320-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 613 - 888 None None 0
2QOBA 1.65 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 609 - 906 None X701 13
3FY2A 1.8 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 607 - 904 A608T None 10
2GSFA 1.77 None DFGin BLAminus in-in in-none No_ligand No_ligand 595 - 904 A608T None 16
2QO2A 1.6 None DFGin BLAminus in-in none-none No_ligand No_ligand 595 - 904 None None 20
2QOKA 1.2 Active DFGin BLAminus in-in in-in No_ligand No_ligand 595 - 904 Y596F,Y602F,S768A None 15
2QONA 1.79 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 595 - 905 Y596F,Y602F,Y742A X701 16
2QOCA 1.25 Inactive DFGin BLAminus in-out in-in ANP Type1 613 - 906 None None 11
4GK3A 1.898 Active DFGin BLAminus in-in in-in L87 Type1 609 - 903 None None 14
4P5QA 1.35 Active DFGin BLAminus in-in in-in Q0B Type1 609 - 904 None None 16
4TWOA 2.047 None DFGin BLAminus in-in in-none 37W Type1 609 - 906 None None 15
3FXXA 1.7 Inactive DFGin BLAminus in-out in-in ANP Type1 606 - 904 A608T None 9
2QO7A 1.605 None DFGin BLAminus in-out none-none ANP Type1 595 - 904 None X701 20
2QO9A 1.55 Inactive DFGin BLAminus in-out in-in ANP Type1 608 - 904 None None 13
2QOQA 1.6 None DFGin BLAminus in-in none-in ANP Type1 595 - 906 None X701 18
4G2FA 1.699 None DFGin BLAminus in-in in-none C07 Type1.5_Back 609 - 903 None None 15
4GK2A 2.195 None DFGin BLAminus in-in none-none L66 Type1.5_Back 609 - 903 None None 19
4GK4A 2.1 Active DFGin BLAminus in-in in-in L90 Type1.5_Back 609 - 903 None None 13
6IN0A 1.501 Inactive DFGin BLAminus in-out in-in O4B O4B Type3 Allosteric 613 - 903 None None 14
2QOOA 1.25 Inactive DFGin None in-in none-none No_ligand No_ligand 595 - 904 Y596F,Y602F,Y742F None 21
2QOFA 1.2 Inactive DFGin None in-in none-none No_ligand No_ligand 595 - 906 Y596F None 21
2QODA 1.15 Inactive DFGin None in-in none-none No_ligand No_ligand 595 - 904 Y602F None 21
2QOIA 1.25 Inactive DFGin None in-in none-none No_ligand No_ligand 595 - 904 Y596F,Y602F None 21
2QOLA 1.07 Inactive DFGin None in-in none-none No_ligand No_ligand 595 - 904 Y596F,Y602F,S768G None 22
4P4CA 1.599 Inactive DFGin None in-in none-none 25Q Type1 613 - 904 None None 21
3DZQA 1.75 Inactive DFGout BBAminus in-in none-none IFC Type2 609 - 904 None None 19
4P5ZA 2.002 Inactive DFGout None in-in none-none Q7M Type2 609 - 903 None None 21
4TWNA 1.706 Inactive DFGout None in-in out-in B96 Type2 609 - 904 None None 15

EPHA3 (Ephrin type-A receptor 3)

Group: TYR
Total number of chains: 28
Spatial Dihedral Chains Representative
DFGin BLAminus 19 AF-P29320-K1A
DFGin None 6 2QODA
DFGout BBAminus 1 3DZQA
DFGout None 2 4TWNA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens EPHA3_HUMAN AF-P29320-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 613 - 888 None None 0
Homo sapiens EPHA3_HUMAN 2QOBA 1.65 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 609 - 906 None X701 13
Homo sapiens EPHA3_HUMAN 3FY2A 1.8 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 607 - 904 A608T None 10
Homo sapiens EPHA3_HUMAN 2GSFA 1.77 None DFGin BLAminus in-in in-none No_ligand No_ligand 595 - 904 A608T None 16
Homo sapiens EPHA3_HUMAN 2QO2A 1.6 None DFGin BLAminus in-in none-none No_ligand No_ligand 595 - 904 None None 20
Homo sapiens EPHA3_HUMAN 2QOKA 1.2 Active DFGin BLAminus in-in in-in No_ligand No_ligand 595 - 904 Y596F,Y602F,S768A None 15
Homo sapiens EPHA3_HUMAN 2QONA 1.79 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 595 - 905 Y596F,Y602F,Y742A X701 16
Homo sapiens EPHA3_HUMAN 2QOCA 1.25 Inactive DFGin BLAminus in-out in-in ANP Type1 613 - 906 None None 11
Homo sapiens EPHA3_HUMAN 4GK3A 1.898 Active DFGin BLAminus in-in in-in L87 Type1 609 - 903 None None 14
Homo sapiens EPHA3_HUMAN 4P5QA 1.35 Active DFGin BLAminus in-in in-in Q0B Type1 609 - 904 None None 16
Homo sapiens EPHA3_HUMAN 4TWOA 2.047 None DFGin BLAminus in-in in-none 37W Type1 609 - 906 None None 15
Homo sapiens EPHA3_HUMAN 3FXXA 1.7 Inactive DFGin BLAminus in-out in-in ANP Type1 606 - 904 A608T None 9
Homo sapiens EPHA3_HUMAN 2QO7A 1.605 None DFGin BLAminus in-out none-none ANP Type1 595 - 904 None X701 20
Homo sapiens EPHA3_HUMAN 2QO9A 1.55 Inactive DFGin BLAminus in-out in-in ANP Type1 608 - 904 None None 13
Homo sapiens EPHA3_HUMAN 2QOQA 1.6 None DFGin BLAminus in-in none-in ANP Type1 595 - 906 None X701 18
Homo sapiens EPHA3_HUMAN 4G2FA 1.699 None DFGin BLAminus in-in in-none C07 Type1.5_Back 609 - 903 None None 15
Homo sapiens EPHA3_HUMAN 4GK2A 2.195 None DFGin BLAminus in-in none-none L66 Type1.5_Back 609 - 903 None None 19
Homo sapiens EPHA3_HUMAN 4GK4A 2.1 Active DFGin BLAminus in-in in-in L90 Type1.5_Back 609 - 903 None None 13
Homo sapiens EPHA3_HUMAN 6IN0A 1.501 Inactive DFGin BLAminus in-out in-in O4B O4B Type3 Allosteric 613 - 903 None None 14
Homo sapiens EPHA3_HUMAN 2QOOA 1.25 Inactive DFGin None in-in none-none No_ligand No_ligand 595 - 904 Y596F,Y602F,Y742F None 21
Homo sapiens EPHA3_HUMAN 2QOFA 1.2 Inactive DFGin None in-in none-none No_ligand No_ligand 595 - 906 Y596F None 21
Homo sapiens EPHA3_HUMAN 2QODA 1.15 Inactive DFGin None in-in none-none No_ligand No_ligand 595 - 904 Y602F None 21
Homo sapiens EPHA3_HUMAN 2QOIA 1.25 Inactive DFGin None in-in none-none No_ligand No_ligand 595 - 904 Y596F,Y602F None 21
Homo sapiens EPHA3_HUMAN 2QOLA 1.07 Inactive DFGin None in-in none-none No_ligand No_ligand 595 - 904 Y596F,Y602F,S768G None 22
Homo sapiens EPHA3_HUMAN 4P4CA 1.599 Inactive DFGin None in-in none-none 25Q Type1 613 - 904 None None 21
Homo sapiens EPHA3_HUMAN 3DZQA 1.75 Inactive DFGout BBAminus in-in none-none IFC Type2 609 - 904 None None 19
Homo sapiens EPHA3_HUMAN 4P5ZA 2.002 Inactive DFGout None in-in none-none Q7M Type2 609 - 903 None None 21
Homo sapiens EPHA3_HUMAN 4TWNA 1.706 Inactive DFGout None in-in out-in B96 Type2 609 - 904 None None 15

EPHA3 (Ephrin type-A receptor 3)

No non-human structures known.