Ligand: AMP

Total number of chains: 28
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 22 7P7GA
DFGin ABAminus 2 7N8TA
DFGin BLBplus 3 6P8QC
DFGin None 1 9GUCA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC GRK6 GRK6_HUMAN 3NYOA 2.92 Active DFGin‑BLAminus in-in in-in AMP Type1 2 - 557 0 None None G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN 3NYOB 2.92 Active DFGin‑BLAminus in-in in-in AMP Type1 2 - 557 0 None None G protein-coupled receptor kinase 6
CAMK AURKA AURKA_HUMAN 6VPMA 1.58 Inactive DFGin‑BLAminus out-out in-out AMP, R74 Type1, Allosteric 7 - 389 4 X288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPMB 1.58 Inactive DFGin‑BLAminus out-out in-out AMP, R74 Type1, Allosteric 7 - 389 4 X288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 9GUCA 2.1 Inactive DFGin‑None out-none none-none ADP, AMP Type1, Allosteric 124 - 391 12 None C290A,C393A Aurora kinase A
CAMK CASK CSKP_HUMAN 3C0HA 2.3 Pseudo DFGin‑BLAminus in-in in-in AMP Type1 5 - 304 0 None None Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3C0HB 2.3 Pseudo DFGin‑BLAminus in-in in-in AMP Type1 5 - 304 0 None None Peripheral plasma membrane protein CASK
CAMK PIM1 PIM1_HUMAN 1YXUA 2.24 Active DFGin‑BLAminus in-in in-in AMP Type1 33 - 305 0 None None Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YXUB 2.24 Active DFGin‑BLAminus in-in in-in AMP Type1 33 - 305 0 None None Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YXUC 2.24 Active DFGin‑BLAminus in-in in-in AMP Type1 34 - 305 0 None None Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YXUD 2.24 Active DFGin‑BLAminus in-in in-in AMP Type1 33 - 305 0 None None Serine/threonine-protein kinase pim-1
CK1 CSNK1D KC1D_HUMAN 7P7FA 1.96 Active DFGin‑BLAminus in-in in-in AMP Type1 3 - 294 0 X220 None Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7FB 1.96 Active DFGin‑BLAminus in-in in-in AMP Type1 3 - 294 0 X220 None Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7GA 1.7 Inactive DFGin‑BLAminus in-in in-out AMP Type1 8 - 294 0 X220 None Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7GB 1.7 Inactive DFGin‑BLAminus in-in in-out AMP Type1 7 - 293 0 X220 None Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7HA 2.4 Active DFGin‑BLAminus in-in in-in AMP Type1 3 - 294 0 None None Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7HB 2.4 Active DFGin‑BLAminus in-in in-in AMP Type1 3 - 294 0 None None Casein kinase I isoform delta
CMGC CDK9 CDK9_HUMAN 4IMYC 2.94 Active DFGin‑BLAminus in-in in-in AMP Type1 8 - 330 0 X186 None Cyclin-dependent kinase 9
CMGC CDK9 CDK9_HUMAN 4IMYE 2.94 Active DFGin‑BLAminus in-in in-in AMP Type1 8 - 330 0 X186 None Cyclin-dependent kinase 9
CMGC CDK9 CDK9_HUMAN 4IMYA 2.94 Active DFGin‑BLAminus in-in in-in AMP Type1.5_Back 8 - 330 0 X186 None Cyclin-dependent kinase 9
CMGC MAPK10 MK10_HUMAN 4KKEA 2.2 Inactive DFGin‑ABAminus in-out out-out AMP Type1 45 - 400 2 None None Mitogen-activated protein kinase 10
CMGC MAPK9 MK09_HUMAN 7N8TA 1.69 Inactive DFGin‑ABAminus in-out out-out AMP Type1 10 - 364 0 None None Mitogen-activated protein kinase 9
OTHER HASPIN HASP_HUMAN 3DLZA 1.85 Active DFGin‑BLAminus in-in in-na AMP Type1 470 - 798 0 None None Serine/threonine-protein kinase haspin
TYR EGFR EGFR_HUMAN 6P8QB 1.9 Inactive DFGin‑BLBplus out-out out-none AMP, O57 Type1, Type3 698 - 1007 10 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P8QC 1.9 Inactive DFGin‑BLBplus out-out out-in AMP, O57 Type1, Type3 699 - 1014 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P8QD 1.9 Inactive DFGin‑BLBplus out-out out-none AMP, O57 Type1, Type3 700 - 1007 12 None T790M,V948R Epidermal growth factor receptor
TYR RET RET_HUMAN 2IVTA 2.6 Inactive DFGin‑BLAminus in-in in-out AMP Type1 703 - 1012 0 X905 None Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 6NE7A 1.99 Inactive DFGin‑BLAminus in-in in-out AMP Type1 705 - 1013 0 X900,X905 G810A Proto-oncogene tyrosine-protein kinase receptor Ret

Ligand: AMP

Total number of chains: 48
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 39 6ESAA
DFGin ABAminus 2 7N8TA
DFGin BLBminus 1 3GC0A
DFGin BLBplus 5 6P8QC
DFGin None 1 9GUCA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CKA1 A0A1D8PUA2_CANAL 6O6QA 2.7 Active DFGin‑BLAminus in-in in-in AMP Type1 4 - 333 0 None None Casein kinase II subunit alpha Candida albicans
CMGC CKA1 A0A1D8PUA2_CANAL 6O6QB 2.7 Active DFGin‑BLAminus in-in in-in AMP Type1 5 - 333 0 None None Casein kinase II subunit alpha Candida albicans
AGC PRKACA KAPCA_CRIGR 6EH2A 1.76 None DFGin‑BLAminus in-none in-in AMP Type1 1 - 351 0 X11,X140,X198,X339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 6ESAA 1.307 Active DFGin‑BLAminus in-in in-in AMP Type1 11 - 351 0 X11,X140,X198,X339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
CAMK CDPK1 A3FQ16_CRYPI 4Y5QA 2.0 Inactive DFGin‑BLBplus out-out out-out AMP Type1 70 - 537 3 None None non-specific serine/threonine protein kinase Cryptosporidium parvum
CAMK CDPK1 A3FQ16_CRYPI 9D8SA 2.12 Inactive DFGin‑BLBplus out-out out-out AMP Type1 70 - 532 0 None None non-specific serine/threonine protein kinase Cryptosporidium parvum
OTHER PK1 A0A097P1P8_GVCP 6VVGA 2.01 Active DFGin‑BLAminus out-na in-in AMP Type1 3 - 279 0 None None PK-1 Cydia pomonella granulosis virus
OTHER PK1 A0A097P1P8_GVCP 6VVGB 2.01 Active DFGin‑BLAminus out-na in-in AMP Type1 3 - 278 0 None None PK-1 Cydia pomonella granulosis virus
TYR SRC SRC_CHICK 3DQXA 2.3 Inactive DFGin‑BLAminus in-out in-in AMP Type1 259 - 533 8 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3DQXB 2.3 Active DFGin‑BLAminus in-in in-in AMP Type1 259 - 533 7 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
CMGC CDK A8BZ95_GIAIC 3GC0A 2.0 Inactive DFGin‑BLBminus out-none out-out AMP Type1 11 - 308 9 None None cyclin-dependent kinase Giardia intestinalis
AGC GRK6 GRK6_HUMAN 3NYOA 2.92 Active DFGin‑BLAminus in-in in-in AMP Type1 2 - 557 0 None None G protein-coupled receptor kinase 6 Homo sapiens
AGC GRK6 GRK6_HUMAN 3NYOB 2.92 Active DFGin‑BLAminus in-in in-in AMP Type1 2 - 557 0 None None G protein-coupled receptor kinase 6 Homo sapiens
CAMK AURKA AURKA_HUMAN 6VPMA 1.58 Inactive DFGin‑BLAminus out-out in-out AMP, R74 Type1, Allosteric 7 - 389 4 X288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6VPMB 1.58 Inactive DFGin‑BLAminus out-out in-out AMP, R74 Type1, Allosteric 7 - 389 4 X288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 9GUCA 2.1 Inactive DFGin‑None out-none none-none ADP, AMP Type1, Allosteric 124 - 391 12 None C290A,C393A Aurora kinase A Homo sapiens
CAMK CASK CSKP_HUMAN 3C0HA 2.3 Pseudo DFGin‑BLAminus in-in in-in AMP Type1 5 - 304 0 None None Peripheral plasma membrane protein CASK Homo sapiens
CAMK CASK CSKP_HUMAN 3C0HB 2.3 Pseudo DFGin‑BLAminus in-in in-in AMP Type1 5 - 304 0 None None Peripheral plasma membrane protein CASK Homo sapiens
CAMK PIM1 PIM1_HUMAN 1YXUA 2.24 Active DFGin‑BLAminus in-in in-in AMP Type1 33 - 305 0 None None Serine/threonine-protein kinase pim-1 Homo sapiens
CAMK PIM1 PIM1_HUMAN 1YXUB 2.24 Active DFGin‑BLAminus in-in in-in AMP Type1 33 - 305 0 None None Serine/threonine-protein kinase pim-1 Homo sapiens
CAMK PIM1 PIM1_HUMAN 1YXUC 2.24 Active DFGin‑BLAminus in-in in-in AMP Type1 34 - 305 0 None None Serine/threonine-protein kinase pim-1 Homo sapiens
CAMK PIM1 PIM1_HUMAN 1YXUD 2.24 Active DFGin‑BLAminus in-in in-in AMP Type1 33 - 305 0 None None Serine/threonine-protein kinase pim-1 Homo sapiens
CK1 CSNK1D KC1D_HUMAN 7P7FA 1.96 Active DFGin‑BLAminus in-in in-in AMP Type1 3 - 294 0 X220 None Casein kinase I isoform delta Homo sapiens
CK1 CSNK1D KC1D_HUMAN 7P7FB 1.96 Active DFGin‑BLAminus in-in in-in AMP Type1 3 - 294 0 X220 None Casein kinase I isoform delta Homo sapiens
CK1 CSNK1D KC1D_HUMAN 7P7GA 1.7 Inactive DFGin‑BLAminus in-in in-out AMP Type1 8 - 294 0 X220 None Casein kinase I isoform delta Homo sapiens
CK1 CSNK1D KC1D_HUMAN 7P7GB 1.7 Inactive DFGin‑BLAminus in-in in-out AMP Type1 7 - 293 0 X220 None Casein kinase I isoform delta Homo sapiens
CK1 CSNK1D KC1D_HUMAN 7P7HA 2.4 Active DFGin‑BLAminus in-in in-in AMP Type1 3 - 294 0 None None Casein kinase I isoform delta Homo sapiens
CK1 CSNK1D KC1D_HUMAN 7P7HB 2.4 Active DFGin‑BLAminus in-in in-in AMP Type1 3 - 294 0 None None Casein kinase I isoform delta Homo sapiens
CMGC CDK9 CDK9_HUMAN 4IMYC 2.94 Active DFGin‑BLAminus in-in in-in AMP Type1 8 - 330 0 X186 None Cyclin-dependent kinase 9 Homo sapiens
CMGC CDK9 CDK9_HUMAN 4IMYE 2.94 Active DFGin‑BLAminus in-in in-in AMP Type1 8 - 330 0 X186 None Cyclin-dependent kinase 9 Homo sapiens
CMGC CDK9 CDK9_HUMAN 4IMYA 2.94 Active DFGin‑BLAminus in-in in-in AMP Type1.5_Back 8 - 330 0 X186 None Cyclin-dependent kinase 9 Homo sapiens
CMGC MAPK10 MK10_HUMAN 4KKEA 2.2 Inactive DFGin‑ABAminus in-out out-out AMP Type1 45 - 400 2 None None Mitogen-activated protein kinase 10 Homo sapiens
CMGC MAPK9 MK09_HUMAN 7N8TA 1.69 Inactive DFGin‑ABAminus in-out out-out AMP Type1 10 - 364 0 None None Mitogen-activated protein kinase 9 Homo sapiens
OTHER HASPIN HASP_HUMAN 3DLZA 1.85 Active DFGin‑BLAminus in-in in-na AMP Type1 470 - 798 0 None None Serine/threonine-protein kinase haspin Homo sapiens
TYR EGFR EGFR_HUMAN 6P8QB 1.9 Inactive DFGin‑BLBplus out-out out-none AMP, O57 Type1, Type3 698 - 1007 10 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6P8QC 1.9 Inactive DFGin‑BLBplus out-out out-in AMP, O57 Type1, Type3 699 - 1014 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6P8QD 1.9 Inactive DFGin‑BLBplus out-out out-none AMP, O57 Type1, Type3 700 - 1007 12 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR RET RET_HUMAN 2IVTA 2.6 Inactive DFGin‑BLAminus in-in in-out AMP Type1 703 - 1012 0 X905 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
TYR RET RET_HUMAN 6NE7A 1.99 Inactive DFGin‑BLAminus in-in in-out AMP Type1 705 - 1013 0 X900,X905 G810A Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
AGC PRKACA KAPCA_MOUSE 1BKXA 2.6 Active DFGin‑BLAminus in-in in-in AMP Type1 13 - 351 0 X11,X198,X339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
CAMK DAPK2 DAPK2_MOUSE 2YABA 1.9 Active DFGin‑BLAminus in-in in-in AMP Type1 13 - 311 0 None None Death-associated protein kinase 2 Mus musculus
CAMK DAPK2 DAPK2_MOUSE 2YABB 1.9 Inactive DFGin‑BLAminus in-out in-in AMP Type1 13 - 311 0 None None Death-associated protein kinase 2 Mus musculus
CMGC MPS1 MPS1_PYROR 8ZTCA 2.26 Inactive DFGin‑BLAminus in-out in-out AMP Type1 5 - 408 0 None None Mitogen-activated protein kinase MPS1 Pyricularia oryzae
OTHER BUD32 BUD32_YEAST 4WW7A 1.669 Active DFGin‑BLAminus in-in in-na AMP Type1 4 - 257 0 None None EKC/KEOPS complex subunit BUD32 Saccharomyces cerevisiae
CMGC ACK2 CSK2A_MAIZE 1DS5A 3.16 Active DFGin‑BLAminus in-in in-in AMP Type1 1 - 328 0 None None Casein kinase II subunit alpha Zea mays
CMGC ACK2 CSK2A_MAIZE 1DS5B 3.16 Active DFGin‑BLAminus in-in in-in AMP Type1 1 - 328 0 None None Casein kinase II subunit alpha Zea mays
CMGC ACK2 CSK2A_MAIZE 1DS5C 3.16 Active DFGin‑BLAminus in-in in-in AMP Type1 1 - 328 0 None None Casein kinase II subunit alpha Zea mays
CMGC ACK2 CSK2A_MAIZE 1DS5D 3.16 Active DFGin‑BLAminus in-in in-in AMP Type1 1 - 328 0 None None Casein kinase II subunit alpha Zea mays

Ligand: AMP

Total number of chains: 20
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 17 6ESAA
DFGin BLBminus 1 3GC0A
DFGin BLBplus 2 4Y5QA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CKA1 A0A1D8PUA2_CANAL 6O6QA 2.7 Active DFGin‑BLAminus in-in in-in AMP Type1 4 - 333 0 None None Casein kinase II subunit alpha Candida albicans
CMGC CKA1 A0A1D8PUA2_CANAL 6O6QB 2.7 Active DFGin‑BLAminus in-in in-in AMP Type1 5 - 333 0 None None Casein kinase II subunit alpha Candida albicans
AGC PRKACA KAPCA_CRIGR 6EH2A 1.76 None DFGin‑BLAminus in-none in-in AMP Type1 1 - 351 0 X11,X140,X198,X339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 6ESAA 1.307 Active DFGin‑BLAminus in-in in-in AMP Type1 11 - 351 0 X11,X140,X198,X339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
CAMK CDPK1 A3FQ16_CRYPI 4Y5QA 2.0 Inactive DFGin‑BLBplus out-out out-out AMP Type1 70 - 537 3 None None non-specific serine/threonine protein kinase Cryptosporidium parvum
CAMK CDPK1 A3FQ16_CRYPI 9D8SA 2.12 Inactive DFGin‑BLBplus out-out out-out AMP Type1 70 - 532 0 None None non-specific serine/threonine protein kinase Cryptosporidium parvum
OTHER PK1 A0A097P1P8_GVCP 6VVGA 2.01 Active DFGin‑BLAminus out-na in-in AMP Type1 3 - 279 0 None None PK-1 Cydia pomonella granulosis virus
OTHER PK1 A0A097P1P8_GVCP 6VVGB 2.01 Active DFGin‑BLAminus out-na in-in AMP Type1 3 - 278 0 None None PK-1 Cydia pomonella granulosis virus
TYR SRC SRC_CHICK 3DQXA 2.3 Inactive DFGin‑BLAminus in-out in-in AMP Type1 259 - 533 8 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3DQXB 2.3 Active DFGin‑BLAminus in-in in-in AMP Type1 259 - 533 7 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
CMGC CDK A8BZ95_GIAIC 3GC0A 2.0 Inactive DFGin‑BLBminus out-none out-out AMP Type1 11 - 308 9 None None cyclin-dependent kinase Giardia intestinalis
AGC PRKACA KAPCA_MOUSE 1BKXA 2.6 Active DFGin‑BLAminus in-in in-in AMP Type1 13 - 351 0 X11,X198,X339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
CAMK DAPK2 DAPK2_MOUSE 2YABA 1.9 Active DFGin‑BLAminus in-in in-in AMP Type1 13 - 311 0 None None Death-associated protein kinase 2 Mus musculus
CAMK DAPK2 DAPK2_MOUSE 2YABB 1.9 Inactive DFGin‑BLAminus in-out in-in AMP Type1 13 - 311 0 None None Death-associated protein kinase 2 Mus musculus
CMGC MPS1 MPS1_PYROR 8ZTCA 2.26 Inactive DFGin‑BLAminus in-out in-out AMP Type1 5 - 408 0 None None Mitogen-activated protein kinase MPS1 Pyricularia oryzae
OTHER BUD32 BUD32_YEAST 4WW7A 1.669 Active DFGin‑BLAminus in-in in-na AMP Type1 4 - 257 0 None None EKC/KEOPS complex subunit BUD32 Saccharomyces cerevisiae
CMGC ACK2 CSK2A_MAIZE 1DS5A 3.16 Active DFGin‑BLAminus in-in in-in AMP Type1 1 - 328 0 None None Casein kinase II subunit alpha Zea mays
CMGC ACK2 CSK2A_MAIZE 1DS5B 3.16 Active DFGin‑BLAminus in-in in-in AMP Type1 1 - 328 0 None None Casein kinase II subunit alpha Zea mays
CMGC ACK2 CSK2A_MAIZE 1DS5C 3.16 Active DFGin‑BLAminus in-in in-in AMP Type1 1 - 328 0 None None Casein kinase II subunit alpha Zea mays
CMGC ACK2 CSK2A_MAIZE 1DS5D 3.16 Active DFGin‑BLAminus in-in in-in AMP Type1 1 - 328 0 None None Casein kinase II subunit alpha Zea mays