Protein kinases in complex with AMP

Total number of genes: 11
Total number of chains: 27
Spatial Dihedral Chains Representative
DFGin BLAminus 22 7P7GA
DFGin ABAminus 2 7N8TA
DFGin BLBplus 3 6P8QC
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
AGC GRK6 GRK6_HUMAN G protein-coupled receptor kinase 6 3NYOA 2.92 Active DFGin BLAminus in-in in-in AMP Type1
AGC GRK6 GRK6_HUMAN G protein-coupled receptor kinase 6 3NYOB 2.92 Active DFGin BLAminus in-in in-in AMP Type1
CAMK AURKA AURKA_HUMAN Aurora kinase A 6VPMA 1.58 Inactive DFGin BLAminus out-out in-out AMP R74 Type1 Allosteric
CAMK AURKA AURKA_HUMAN Aurora kinase A 6VPMB 1.58 Inactive DFGin BLAminus out-out in-out AMP R74 Type1 Allosteric
CAMK CASK CSKP_HUMAN Peripheral plasma membrane protein CASK 3C0HA 2.3 Active DFGin BLAminus in-in in-in AMP Type1
CAMK CASK CSKP_HUMAN Peripheral plasma membrane protein CASK 3C0HB 2.3 Active DFGin BLAminus in-in in-in AMP Type1
CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 1YXUA 2.24 Active DFGin BLAminus in-in in-in AMP Type1
CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 1YXUB 2.24 Active DFGin BLAminus in-in in-in AMP Type1
CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 1YXUC 2.24 Active DFGin BLAminus in-in in-in AMP Type1
CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 1YXUD 2.24 Active DFGin BLAminus in-in in-in AMP Type1
CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 7P7FA 1.96 Active DFGin BLAminus in-in in-in AMP Type1
CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 7P7FB 1.96 Active DFGin BLAminus in-in in-in AMP Type1
CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 7P7GA 1.7 Inactive DFGin BLAminus in-in in-out AMP Type1
CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 7P7GB 1.7 Active DFGin BLAminus in-in in-in AMP Type1
CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 7P7HA 2.4 Active DFGin BLAminus in-in in-in AMP Type1
CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 7P7HB 2.4 Active DFGin BLAminus in-in in-in AMP Type1
CMGC CDK9 CDK9_HUMAN Cyclin-dependent kinase 9 4IMYC 2.94 Active DFGin BLAminus in-in in-in AMP Type1
CMGC CDK9 CDK9_HUMAN Cyclin-dependent kinase 9 4IMYE 2.94 Active DFGin BLAminus in-in in-in AMP Type1
CMGC CDK9 CDK9_HUMAN Cyclin-dependent kinase 9 4IMYA 2.94 Active DFGin BLAminus in-in in-in AMP Type1.5_Back
CMGC MAPK10 MK10_HUMAN Mitogen-activated protein kinase 10 4KKEA 2.2 Inactive DFGin ABAminus in-out out-out AMP Type1
CMGC MAPK9 MK09_HUMAN Mitogen-activated protein kinase 9 7N8TA 1.69 Inactive DFGin ABAminus in-out out-out AMP Type1
OTHER HASPIN HASP_HUMAN Serine/threonine-protein kinase haspin 3DLZA 1.85 Active DFGin BLAminus in-in in-none AMP Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 6P8QB 1.9 Inactive DFGin BLBplus out-out out-in AMP O57 Type1 Type3
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 6P8QC 1.9 Inactive DFGin BLBplus out-out out-in AMP O57 Type1 Type3
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 6P8QD 1.9 Inactive DFGin BLBplus out-out out-in AMP O57 Type1 Type3
TYR RET RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret 2IVTA 2.6 Active DFGin BLAminus in-in in-in AMP Type1
TYR RET RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret 6NE7A 1.99 Active DFGin BLAminus in-in in-in AMP Type1

Protein kinases in complex with AMP

Total number of genes: 20
Total number of chains: 44
Spatial Dihedral Chains Representative
DFGin BLAminus 37 6ESAA
DFGin ABAminus 2 7N8TA
DFGin BLBminus 1 3GC0A
DFGin BLBplus 4 6P8QC
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Candida albicans CMGC CKA1 A0A1D8PUA2_CANAL Casein kinase 2 catalytic subunit 6O6QA 2.7 Active DFGin BLAminus in-in in-in AMP Type1
Candida albicans CMGC CKA1 A0A1D8PUA2_CANAL Casein kinase 2 catalytic subunit 6O6QB 2.7 Active DFGin BLAminus in-in in-in AMP Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 6EH2A 1.76 None DFGin BLAminus in-none in-in AMP Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 6ESAA 1.307 Active DFGin BLAminus in-in in-in AMP Type1
Cryptosporidium parvum CAMK CDPK1 A3FQ16_CRYPI Calmodulin-domain protein kinase 1, putative 4Y5QA 2.0 Inactive DFGin BLBplus out-out out-out AMP Type1
Cydia pomonella granulosis virus OTHER PK1 A0A097P1P8_GVCP PK-1 6VVGA 2.01 Inactive DFGin BLAminus out-out in-in AMP Type1
Cydia pomonella granulosis virus OTHER PK1 A0A097P1P8_GVCP PK-1 6VVGB 2.01 Inactive DFGin BLAminus out-out in-in AMP Type1
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 3DQXA 2.3 Inactive DFGin BLAminus in-out in-in AMP Type1
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 3DQXB 2.3 Active DFGin BLAminus in-in in-in AMP Type1
Giardia intestinalis CMGC CDK A8BZ95_GIAIC Kinase, CMGC CDK 3GC0A 2.0 Inactive DFGin BLBminus out-none out-out AMP Type1
Homo sapiens AGC GRK6 GRK6_HUMAN G protein-coupled receptor kinase 6 3NYOA 2.92 Active DFGin BLAminus in-in in-in AMP Type1
Homo sapiens AGC GRK6 GRK6_HUMAN G protein-coupled receptor kinase 6 3NYOB 2.92 Active DFGin BLAminus in-in in-in AMP Type1
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 6VPMA 1.58 Inactive DFGin BLAminus out-out in-out AMP R74 Type1 Allosteric
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 6VPMB 1.58 Inactive DFGin BLAminus out-out in-out AMP R74 Type1 Allosteric
Homo sapiens CAMK CASK CSKP_HUMAN Peripheral plasma membrane protein CASK 3C0HA 2.3 Active DFGin BLAminus in-in in-in AMP Type1
Homo sapiens CAMK CASK CSKP_HUMAN Peripheral plasma membrane protein CASK 3C0HB 2.3 Active DFGin BLAminus in-in in-in AMP Type1
Homo sapiens CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 1YXUA 2.24 Active DFGin BLAminus in-in in-in AMP Type1
Homo sapiens CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 1YXUB 2.24 Active DFGin BLAminus in-in in-in AMP Type1
Homo sapiens CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 1YXUC 2.24 Active DFGin BLAminus in-in in-in AMP Type1
Homo sapiens CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 1YXUD 2.24 Active DFGin BLAminus in-in in-in AMP Type1
Homo sapiens CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 7P7FA 1.96 Active DFGin BLAminus in-in in-in AMP Type1
Homo sapiens CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 7P7FB 1.96 Active DFGin BLAminus in-in in-in AMP Type1
Homo sapiens CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 7P7GA 1.7 Inactive DFGin BLAminus in-in in-out AMP Type1
Homo sapiens CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 7P7GB 1.7 Active DFGin BLAminus in-in in-in AMP Type1
Homo sapiens CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 7P7HA 2.4 Active DFGin BLAminus in-in in-in AMP Type1
Homo sapiens CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 7P7HB 2.4 Active DFGin BLAminus in-in in-in AMP Type1
Homo sapiens CMGC CDK9 CDK9_HUMAN Cyclin-dependent kinase 9 4IMYC 2.94 Active DFGin BLAminus in-in in-in AMP Type1
Homo sapiens CMGC CDK9 CDK9_HUMAN Cyclin-dependent kinase 9 4IMYE 2.94 Active DFGin BLAminus in-in in-in AMP Type1
Homo sapiens CMGC CDK9 CDK9_HUMAN Cyclin-dependent kinase 9 4IMYA 2.94 Active DFGin BLAminus in-in in-in AMP Type1.5_Back
Homo sapiens CMGC MAPK10 MK10_HUMAN Mitogen-activated protein kinase 10 4KKEA 2.2 Inactive DFGin ABAminus in-out out-out AMP Type1
Homo sapiens CMGC MAPK9 MK09_HUMAN Mitogen-activated protein kinase 9 7N8TA 1.69 Inactive DFGin ABAminus in-out out-out AMP Type1
Homo sapiens OTHER HASPIN HASP_HUMAN Serine/threonine-protein kinase haspin 3DLZA 1.85 Active DFGin BLAminus in-in in-none AMP Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 6P8QB 1.9 Inactive DFGin BLBplus out-out out-in AMP O57 Type1 Type3
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 6P8QC 1.9 Inactive DFGin BLBplus out-out out-in AMP O57 Type1 Type3
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 6P8QD 1.9 Inactive DFGin BLBplus out-out out-in AMP O57 Type1 Type3
Homo sapiens TYR RET RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret 2IVTA 2.6 Active DFGin BLAminus in-in in-in AMP Type1
Homo sapiens TYR RET RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret 6NE7A 1.99 Active DFGin BLAminus in-in in-in AMP Type1
Mus musculus CAMK DAPK2 DAPK2_MOUSE Death-associated protein kinase 2 2YABA 1.9 Active DFGin BLAminus in-in in-in AMP Type1
Mus musculus CAMK DAPK2 DAPK2_MOUSE Death-associated protein kinase 2 2YABB 1.9 Inactive DFGin BLAminus in-out in-in AMP Type1
Saccharomyces cerevisiae OTHER BUD32 BUD32_YEAST EKC/KEOPS complex subunit BUD32 4WW7A 1.669 Active DFGin BLAminus in-in in-none AMP Type1
Zea mays CMGC ACK2 CSK2A_MAIZE Casein kinase II subunit alpha 1DS5A 3.16 Active DFGin BLAminus in-in in-in AMP Type1
Zea mays CMGC ACK2 CSK2A_MAIZE Casein kinase II subunit alpha 1DS5B 3.16 Active DFGin BLAminus in-in in-in AMP Type1
Zea mays CMGC ACK2 CSK2A_MAIZE Casein kinase II subunit alpha 1DS5C 3.16 Active DFGin BLAminus in-in in-in AMP Type1
Zea mays CMGC ACK2 CSK2A_MAIZE Casein kinase II subunit alpha 1DS5D 3.16 Active DFGin BLAminus in-in in-in AMP Type1

Protein kinases in complex with AMP

Total number of genes: 9
Total number of chains: 17
Spatial Dihedral Chains Representative
DFGin BLAminus 15 6ESAA
DFGin BLBminus 1 3GC0A
DFGin BLBplus 1 4Y5QA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Candida albicans CMGC CKA1 A0A1D8PUA2_CANAL Casein kinase 2 catalytic subunit 6O6QA 2.7 Active DFGin BLAminus in-in in-in AMP Type1
Candida albicans CMGC CKA1 A0A1D8PUA2_CANAL Casein kinase 2 catalytic subunit 6O6QB 2.7 Active DFGin BLAminus in-in in-in AMP Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 6EH2A 1.76 None DFGin BLAminus in-none in-in AMP Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 6ESAA 1.307 Active DFGin BLAminus in-in in-in AMP Type1
Cryptosporidium parvum CAMK CDPK1 A3FQ16_CRYPI Calmodulin-domain protein kinase 1, putative 4Y5QA 2.0 Inactive DFGin BLBplus out-out out-out AMP Type1
Cydia pomonella granulosis virus OTHER PK1 A0A097P1P8_GVCP PK-1 6VVGA 2.01 Inactive DFGin BLAminus out-out in-in AMP Type1
Cydia pomonella granulosis virus OTHER PK1 A0A097P1P8_GVCP PK-1 6VVGB 2.01 Inactive DFGin BLAminus out-out in-in AMP Type1
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 3DQXA 2.3 Inactive DFGin BLAminus in-out in-in AMP Type1
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 3DQXB 2.3 Active DFGin BLAminus in-in in-in AMP Type1
Giardia intestinalis CMGC CDK A8BZ95_GIAIC Kinase, CMGC CDK 3GC0A 2.0 Inactive DFGin BLBminus out-none out-out AMP Type1
Mus musculus CAMK DAPK2 DAPK2_MOUSE Death-associated protein kinase 2 2YABA 1.9 Active DFGin BLAminus in-in in-in AMP Type1
Mus musculus CAMK DAPK2 DAPK2_MOUSE Death-associated protein kinase 2 2YABB 1.9 Inactive DFGin BLAminus in-out in-in AMP Type1
Saccharomyces cerevisiae OTHER BUD32 BUD32_YEAST EKC/KEOPS complex subunit BUD32 4WW7A 1.669 Active DFGin BLAminus in-in in-none AMP Type1
Zea mays CMGC ACK2 CSK2A_MAIZE Casein kinase II subunit alpha 1DS5A 3.16 Active DFGin BLAminus in-in in-in AMP Type1
Zea mays CMGC ACK2 CSK2A_MAIZE Casein kinase II subunit alpha 1DS5B 3.16 Active DFGin BLAminus in-in in-in AMP Type1
Zea mays CMGC ACK2 CSK2A_MAIZE Casein kinase II subunit alpha 1DS5C 3.16 Active DFGin BLAminus in-in in-in AMP Type1
Zea mays CMGC ACK2 CSK2A_MAIZE Casein kinase II subunit alpha 1DS5D 3.16 Active DFGin BLAminus in-in in-in AMP Type1