TYR_KDR (Vascular endothelial growth factor receptor 2)

Total number of chains: 54
Active chains: 2
Family: TYR
Uniprot: VGFR2_HUMAN
Kinase Domain Residues: 834 - 1162
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 32 59.3% 6GQQA
DFGout None 9 16.7% 3VO3A
DFGin BLAminus 3 5.6% AF-P35968-K1A
DFGin BLBplus 3 5.6% 3WZDA
None None 3 5.6% 3CJFA
DFGinter None 2 3.7% 1Y6BA
DFGin BLAplus 1 1.9% 2P2HA
DFGin None 1 1.9% 1VR2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P35968-K1A 826 1170 1356.0 No_ligand No_ligand Active DFGin 6.724 13.754 BLAminus -135.49, -178.07 64.31, 58.61 -79.84, 14.65 291.25, 84.84 -59.67, -29.27 in-in in 7.274 Saltbr-in 2.654 HRD-in -79.81, -44.23 66.36, -15.09 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.88, 109.91 APE9-dihe-in -121.83, 150.33 APE8-dihe-in -76.73, 95.83 APE8-rot-na 34.09 APE67-dihe-in -64.1, -25.24 -52.96, -31.45 APE12-dist-na 14.175 APE11-dist-na 7.936 APE10-dist-na 10.731 APE9-dist-in 6.196 None None None AF2 -1.0 1.0 1.0 A 345 345 0 0 0 0 [[834, 1162]] 1.0 AF-P35968-K1 TYR_KDR_HUMAN TYR 2.1e-99 338.0 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
AF-P35968-K3A 826 1170 1356.0 No_ligand No_ligand Active DFGin 6.467 13.46 BLAminus -139.09, -177.77 61.66, 65.38 -79.85, 17.72 289.99, 89.58 -61.52, -31.06 in-in in 7.822 Saltbr-in 2.729 HRD-in -81.16, -45.43 63.07, 4.14 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -52.76, 130.74 APE9-dihe-in -112.3, 130.74 APE8-dihe-in -82.3, 61.23 APE8-rot-na 36.08 APE67-dihe-in -68.73, -19.78 -48.02, -36.64 APE12-dist-na 13.331 APE11-dist-na 7.163 APE10-dist-na 8.538 APE9-dist-in 6.757 None None None AF2 -1.0 1.0 1.0 A 345 345 0 0 0 0 [[834, 1162]] 1.0 AF-P35968-K3 TYR_KDR_HUMAN TYR 2.1e-99 338.0 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3CJGA 816 1168 1356.0 KIM:61167 Type1 Inactive DFGin 7.412 14.128 BLAminus -120.91, -162.35 48.63, 86.88 -107.47, 22.59 302.68, 92.72 -76.12, -15.36 in-in in 7.179 Saltbr-in 2.681 HRD-in -77.13, -50.16 74.93, 1.17 in-in-out SNCiio in-out ActLoopNT-in 2.977 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 19.76 APE8-rot-na 1.33 APE67-dihe-out -66.63, -12.94 74.8, -54.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None CSO862,CSO1024 XRAY 2.25 0.209 0.253 A 309 282 17 0 0 14 [[834, 1162]] 1.0 3cjg TYR_KDR_HUMAN TYR 4.8e-100 340.1 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
2P2HA 815 1172 1356.0 994:60501 Type1 Inactive DFGin 5.778 13.494 BLAplus -120.41, 168.7 57.61, 43.27 -102.94, -14.81 60.29, 84.2 -108.45, 28.25 in-in in 7.35 Saltbr-in 2.527 HRD-in -63.68, -53.12 82.34, -19.49 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, 158.7 APE9-dihe-out 54.03, 51.67 APE8-dihe-out -62.29, -19.22 APE8-rot-na 32.86 APE67-dihe-in -68.4, -12.54 -60.9, -27.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 19.04 APE9-dist-out 11.181 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 1.95 0.205 0.229 A 314 289 19 0 0 15 [[834, 1162]] 1.0 2p2h TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3WZDA 820 1167 1356.0 LEV:1201 Type1 Inactive DFGin 5.426 13.803 BLBplus -131.31, 171.12 64.88, 24.46 -69.96, 136.97 45.36, 91.24 79.76, 6.08 in-in in 7.309 Saltbr-in 2.943 HRD-in -65.52, -53.13 82.13, -20.42 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -70.62 APE8-dihe-out -53.22, -31.36 APE8-rot-na 22.8 APE67-dihe-in -66.02, -15.12 -58.21, -29.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.248 T940V None None XRAY 1.57 0.184 0.212 A 309 278 20 0 0 16 [[834, 1162]] 1.0 3wzd TYR_KDR_HUMAN TYR 3.7e-100 340.4 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3B8RA 818 1171 1356.0 887:60201 Type1 Inactive DFGin 5.424 13.871 BLBplus -147.04, 169.16 57.66, 43.33 -97.43, 156.79 47.05, 78.4 59.04, 37.41 in-in in 7.251 Saltbr-in 2.68 HRD-in -59.31, -52.93 80.34, -8.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 162.25 APE8-dihe-out -73.03, -9.68 APE8-rot-na 326.59 APE67-dihe-in -61.58, -18.77 -55.36, -31.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.259 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.7 0.204 0.259 A 314 282 22 0 0 17 [[834, 1162]] 1.0 3b8r TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3B8RB 821 1166 1356.0 887:60202 Type1 Inactive DFGin 5.442 13.886 BLBplus -153.23, 176.22 49.55, 49.42 -108.14, 150.46 48.31, 72.77 69.58, 35.57 in-in in 7.393 Saltbr-in 2.745 HRD-in -68.34, -51.75 79.37, -8.5 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.55 APE8-dihe-out -62.02, -11.57 APE8-rot-na 326.58 APE67-dihe-in -65.24, -19.42 -57.92, -26.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.261 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.7 0.204 0.259 B 314 267 29 0 0 17 [[834, 1162]] 1.0 3b8r TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
1VR2A 820 1168 1356.0 No_ligand No_ligand Inactive DFGin 6.197 12.201 None -132.36, 167.84 67.89, 27.54 -86.08, 999.0 49.78, 130.84 999.0, 999.0 in-in in 7.73 Saltbr-in 2.99 HRD-in -66.37, -43.4 76.06, -15.34 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -137.43, 155.04 APE9-dihe-in -108.73, 90.95 APE8-dihe-out -47.33, -14.52 APE8-rot-na 323.83 APE67-dihe-in -64.29, -7.8 -69.97, -29.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.466 E990V PTR1059 PTR1059 XRAY 2.4 0.215 999.0 A 316 275 24 0 0 16 [[834, 1162]] 1.0 1vr2 TYR_KDR_HUMAN TYR 4.1e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
1Y6AA 820 1167 1356.0 AAZ:60201 Type1 Inactive DFGinter 8.666 8.838 None -73.14, 116.72 -103.71, 73.1 -178.89, 999.0 25.84, 61.42 999.0, 999.0 in-in in 7.47 Saltbr-in 2.801 HRD-in -83.04, -53.13 81.96, -16.64 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -20.95 APE8-rot-na 328.99 APE67-dihe-in -63.85, -16.51 -63.27, -26.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.196 0.217 A 366 261 87 0 0 20 [[834, 1162]] 1.0 1y6a TYR_KDR_HUMAN TYR 2.6e-99 337.7 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
1Y6BA 819 1168 1356.0 AAX:60201 Type1 Inactive DFGinter 8.959 8.691 None -70.35, 112.74 -90.68, -29.02 -42.32, 999.0 351.89, 106.67 999.0, 999.0 in-in in 7.482 Saltbr-in 2.957 HRD-in -82.96, -58.21 87.46, -12.31 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 69.65 APE8-rot-na 33.76 APE67-dihe-in -65.54, -15.03 -63.36, -37.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.194 0.236 A 366 266 84 0 0 20 [[834, 1162]] 1.0 1y6b TYR_KDR_HUMAN TYR 2.6e-99 337.7 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
4AG8A 816 1168 1356.0 AXI:2000 Type1 Inactive DFGout 16.497 10.362 BBAminus -143.7, -179.58 -144.17, 113.57 -60.35, -33.13 275.19, 77.68 54.27, -121.79 in-in in 7.519 Saltbr-in 2.748 HRD-in -80.25, -53.16 76.08, -12.6 in-out-in SNCioi out-in ActLoopNT-out 16.566 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.55, 111.08 APE9-dihe-in -116.46, 147.01 APE8-dihe-in -77.77, 66.25 APE8-rot-na 30.85 APE67-dihe-in -66.26, -17.06 -55.96, -37.76 APE12-dist-na 16.456 APE11-dist-na 13.513 APE10-dist-na 11.473 APE9-dist-in 7.983 E990V None None XRAY 1.95 0.197 0.241 A 316 296 7 0 0 0 [[834, 1162]] 1.0 4ag8 TYR_KDR_HUMAN TYR 4.1e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
4AGDA 802 1169 1356.0 B49:2000 Type1 Inactive DFGout 16.069 10.723 BBAminus -138.96, 169.29 -127.17, 103.68 -55.8, -25.22 266.19, 75.17 52.13, -127.76 in-in in 6.778 Saltbr-in 3.023 HRD-out -100.33, 104.42 -84.72, 20.62 in-out-in SNCioi out-in ActLoopNT-out 15.854 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.84, 115.98 APE9-dihe-in -119.8, 140.98 APE8-dihe-in -66.9, 64.41 APE8-rot-na 27.14 APE67-dihe-in -54.0, -28.9 -62.45, -38.96 APE12-dist-na 16.473 APE11-dist-na 15.651 APE10-dist-na 13.29 APE9-dist-in 7.777 E990V None None XRAY 2.81 0.21 0.307 A 353 304 7 0 0 0 [[834, 1162]] 1.0 4agd TYR_KDR_HUMAN TYR 6e-100 339.8 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3CPBB 820 1165 1356.0 C92:60002 Type1 Inactive DFGout 15.47 9.898 BBAminus -145.95, -173.33 -148.66, 122.86 -90.71, -55.39 280.65, 93.5 148.13, 999.0 in-in in 7.466 Saltbr-in 2.743 HRD-in -84.85, -49.1 84.19, -23.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -49.62 APE8-dihe-out -64.93, -12.78 APE8-rot-na 24.8 APE67-dihe-in -63.19, -14.98 -60.0, -29.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.363 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.7 0.224 0.286 B 314 263 33 0 0 18 [[834, 1162]] 1.0 3cpb TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
2XIRA 816 1168 1356.0 00J:2169 Type1.5_Back Inactive DFGout 15.972 9.922 BBAminus -148.97, -178.6 -143.75, 112.04 -61.18, -32.48 278.24, 81.67 54.1, -120.79 in-in in 7.693 Saltbr-in 2.739 HRD-in -84.85, -55.21 79.77, -10.15 in-out-in SNCioi out-in ActLoopNT-out 16.772 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.39, 115.13 APE9-dihe-in -121.67, 148.38 APE8-dihe-in -77.59, 66.04 APE8-rot-na 29.49 APE67-dihe-in -66.29, -14.94 -52.56, -39.25 APE12-dist-na 16.968 APE11-dist-na 13.328 APE10-dist-na 11.46 APE9-dist-in 7.91 E990V None None XRAY 1.5 0.219 0.238 A 316 296 7 0 0 0 [[834, 1162]] 1.0 2xir TYR_KDR_HUMAN TYR 4.1e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
4AGCA 801 1169 1356.0 AXI:2000 Type1.5_Back Inactive DFGout 16.342 10.451 BBAminus -142.09, -174.91 -148.19, 116.12 -63.13, -37.04 279.42, 73.43 58.39, -117.25 in-in in 7.347 Saltbr-in 2.669 HRD-out -119.32, 107.11 -77.42, 1.81 in-out-in SNCioi out-in ActLoopNT-out 16.525 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.04, 119.4 APE9-dihe-in -126.34, 146.64 APE8-dihe-in -75.44, 63.67 APE8-rot-na 28.57 APE67-dihe-in -65.72, -15.94 -53.26, -41.15 APE12-dist-na 16.758 APE11-dist-na 14.426 APE10-dist-na 12.23 APE9-dist-in 7.621 E990V None None XRAY 2.0 0.204 0.251 A 353 305 7 0 0 0 [[834, 1162]] 1.0 4agc TYR_KDR_HUMAN TYR 6e-100 339.8 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3WZEA 815 1167 1356.0 BAX:1201 Type2 Inactive DFGout 15.423 9.724 BBAminus -149.68, 178.07 -142.38, 105.98 -66.68, -30.19 278.49, 88.73 48.89, -116.05 in-in in 7.489 Saltbr-in 2.791 HRD-in -80.41, -52.96 79.37, -11.85 in-out-out SNCioo out-out ActLoopNT-out 16.658 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -114.24, 115.23 APE9-dihe-in -125.6, 147.79 APE8-dihe-in -77.19, 70.99 APE8-rot-na 33.48 APE67-dihe-in -66.14, -18.73 -60.64, -36.14 APE12-dist-na 999.0 APE11-dist-na 13.7 APE10-dist-na 11.342 APE9-dist-out 8.081 T940V None None XRAY 1.9 0.188 0.224 A 309 298 5 0 0 1 [[834, 1162]] 1.0 3wze TYR_KDR_HUMAN TYR 3.7e-100 340.4 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
2OH4A 816 1171 1356.0 GIG:60303 Type2 Inactive DFGout 15.031 10.896 BBAminus -143.49, 178.34 -145.54, 97.19 -58.33, -39.73 283.57, 84.4 57.49, 37.59 in-in in 7.356 Saltbr-in 2.634 HRD-in -73.75, -53.05 85.59, -23.47 in-out-out SNCioo out-out ActLoopNT-out 17.855 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -140.49, 159.6 APE9-dihe-in -103.67, 100.95 APE8-dihe-out -54.41, -26.49 APE8-rot-na 335.24 APE67-dihe-in -67.64, -14.75 -51.43, -34.8 APE12-dist-na 13.307 APE11-dist-na 12.794 APE10-dist-na 13.546 APE9-dist-out 11.206 None PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.05 0.189 0.231 A 316 299 6 0 0 0 [[834, 1162]] 1.0 2oh4 TYR_KDR_HUMAN TYR 5.6e-100 339.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
2P2IA 817 1172 1356.0 608:60501 Type2 Inactive DFGout 16.646 10.42 BBAminus -140.93, -165.49 -165.76, 112.99 -76.4, -20.94 281.97, 76.28 -89.36, -168.3 in-in in 7.487 Saltbr-in 2.878 HRD-in -67.84, -45.58 77.98, -15.16 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.47 APE8-dihe-in -74.22, 56.93 APE8-rot-na 34.49 APE67-dihe-in -67.46, -12.22 -54.19, -35.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.65 C817A,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.4 0.222 0.266 A 314 283 23 0 0 16 [[834, 1162]] 1.0 2p2i TYR_KDR_HUMAN TYR 4e-100 340.4 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3EFLA 817 1171 1356.0 706:60501 Type2 Inactive DFGout 16.18 10.559 BBAminus -138.71, -172.72 -156.17, 97.27 -59.6, -16.87 285.84, 75.59 69.09, 999.0 in-in in 7.333 Saltbr-in 2.822 HRD-in -65.88, -53.9 89.41, -28.23 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 54.05 APE8-rot-na 34.8 APE67-dihe-in -59.53, -20.45 -52.35, -30.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C817A,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.2 0.23 0.264 A 314 279 26 0 0 19 [[834, 1162]] 1.0 3efl TYR_KDR_HUMAN TYR 4e-100 340.4 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3EFLB 821 1165 1356.0 706:60502 Type2 Inactive DFGout 16.113 10.23 BBAminus -141.16, -175.15 -153.12, 108.94 -69.6, -34.74 280.14, 78.23 138.83, 999.0 in-in in 7.096 Saltbr-in 3.242 HRD-in -62.3, -53.81 81.7, -4.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.71 APE8-dihe-out -39.02, -20.75 APE8-rot-na 27.77 APE67-dihe-in -68.47, -11.11 -59.68, -39.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.82 C817A,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.2 0.23 0.264 B 314 263 32 0 0 18 [[834, 1162]] 1.0 3efl TYR_KDR_HUMAN TYR 4e-100 340.4 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
5EW3A 821 1168 1356.0 5T2:1201 Type2 Inactive DFGout 15.88 10.082 BBAminus -139.44, -178.76 -147.6, 111.79 -72.49, -35.99 276.01, 89.46 -76.06, 999.0 in-in in 7.423 Saltbr-in 2.964 HRD-in -64.57, -50.86 83.75, -23.1 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -57.13 APE8-dihe-in -81.64, 66.53 APE8-rot-na 27.98 APE67-dihe-in -64.62, -30.42 -51.68, -35.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.717 None None None XRAY 2.5 0.219 0.254 A 316 274 24 0 0 18 [[834, 1162]] 1.0 5ew3 TYR_KDR_HUMAN TYR 4.1e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
5EW3B 820 1165 1356.0 5T2:1201 Type2 Inactive DFGout 15.862 10.107 BBAminus -138.44, -179.7 -148.59, 111.71 -71.05, -37.05 275.98, 95.16 -74.59, 999.0 in-in in 7.217 Saltbr-in 2.905 HRD-in -64.78, -51.26 84.58, -25.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.03 APE8-dihe-in -87.05, 66.83 APE8-rot-na 29.69 APE67-dihe-in -64.72, -30.16 -52.26, -35.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.665 None None None XRAY 2.5 0.219 0.254 B 316 266 30 0 0 18 [[834, 1162]] 1.0 5ew3 TYR_KDR_HUMAN TYR 4.1e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
6GQOA 811 1168 1356.0 F82:61201 Type2 Inactive DFGout 15.51 9.872 BBAminus -137.41, -174.48 -148.75, 103.09 -62.92, -33.23 281.85, 85.18 53.53, -124.22 in-in in 7.652 Saltbr-in 2.842 HRD-in -77.93, -60.11 81.09, -6.45 in-out-in SNCioi out-in ActLoopNT-out 16.478 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.71, 109.7 APE9-dihe-in -116.16, 147.79 APE8-dihe-in -80.04, 70.94 APE8-rot-na 31.31 APE67-dihe-in -64.81, -13.7 -51.33, -43.39 APE12-dist-na 16.398 APE11-dist-na 13.212 APE10-dist-na 11.091 APE9-dist-in 7.951 None None None XRAY 1.87 0.174 0.207 A 322 307 0 0 0 0 [[834, 1162]] 1.0 6gqo TYR_KDR_HUMAN TYR 4.4e-100 340.2 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
6GQPA 821 1168 1356.0 F88:61201 Type2 Inactive DFGout 16.041 9.828 BBAminus -137.29, -179.39 -147.6, 105.82 -66.11, -30.27 279.44, 81.63 58.93, -133.79 in-in in 7.784 Saltbr-in 3.16 HRD-in -72.29, -59.65 82.33, -13.78 in-out-out SNCioo out-out ActLoopNT-out 16.787 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -109.31, 108.64 APE9-dihe-in -119.08, 147.18 APE8-dihe-in -76.82, 68.93 APE8-rot-na 29.84 APE67-dihe-in -64.0, -17.44 -48.7, -44.35 APE12-dist-na 16.28 APE11-dist-na 13.029 APE10-dist-na 10.463 APE9-dist-out 8.02 None None None XRAY 2.09 0.201 0.234 A 322 298 0 0 0 0 [[834, 1162]] 1.0 6gqp TYR_KDR_HUMAN TYR 4.4e-100 340.2 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
6GQQA 813 1167 1356.0 F8B:61201 Type2 Inactive DFGout 16.318 9.893 BBAminus -140.35, 179.68 -146.82, 105.0 -62.58, -33.91 278.73, 81.84 52.08, -122.03 in-in in 7.855 Saltbr-in 2.87 HRD-in -79.41, -58.06 81.99, -7.96 in-out-out SNCioo out-out ActLoopNT-out 16.642 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -102.87, 113.66 APE9-dihe-in -116.65, 151.24 APE8-dihe-in -82.45, 66.44 APE8-rot-na 31.58 APE67-dihe-in -64.76, -12.48 -47.19, -45.1 APE12-dist-na 16.867 APE11-dist-na 13.207 APE10-dist-na 11.633 APE9-dist-out 8.047 None None None XRAY 1.52 0.178 0.204 A 322 304 0 0 0 0 [[834, 1162]] 1.0 6gqq TYR_KDR_HUMAN TYR 4.4e-100 340.2 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
6XVJA 813 1167 1356.0 O35:1201 Type2 Inactive DFGout 15.797 9.86 BBAminus -132.46, -168.17 -160.35, 90.75 -54.1, -41.9 283.85, 84.23 55.21, -117.78 in-in in 7.713 Saltbr-in 2.862 HRD-in -84.82, -59.51 82.99, -12.32 in-out-in SNCioi out-in ActLoopNT-out 16.682 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.56, 109.17 APE9-dihe-in -116.73, 149.21 APE8-dihe-in -78.94, 66.26 APE8-rot-na 30.73 APE67-dihe-in -62.92, -14.21 -46.08, -45.25 APE12-dist-na 17.103 APE11-dist-na 13.504 APE10-dist-na 11.345 APE9-dist-in 7.992 E990V None None XRAY 1.78 0.18 0.215 A 322 305 0 0 0 0 [[834, 1162]] 1.0 6xvj TYR_KDR_HUMAN TYR 4.4e-100 340.2 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
6XVKA 821 1168 1356.0 O3E:1201 Type2 Inactive DFGout 16.107 9.975 BBAminus -141.36, -173.76 -156.84, 95.12 -54.67, -41.12 280.3, 80.99 54.89, -110.87 in-in in 7.682 Saltbr-in 2.816 HRD-in -73.74, -55.3 80.84, -9.06 in-out-in SNCioi out-in ActLoopNT-out 16.606 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.81, 104.06 APE9-dihe-in -104.53, 149.15 APE8-dihe-in -78.71, 70.31 APE8-rot-na 29.7 APE67-dihe-in -63.75, -14.49 -47.12, -46.79 APE12-dist-na 16.777 APE11-dist-na 12.961 APE10-dist-na 11.381 APE9-dist-in 7.676 E990V None None XRAY 1.99 0.208 0.244 A 322 298 0 0 0 0 [[834, 1162]] 1.0 6xvk TYR_KDR_HUMAN TYR 4.4e-100 340.2 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
4ASDA 807 1168 1356.0 BAX:1500 Type2 Inactive DFGout 15.598 9.565 BBAminus -143.46, -179.3 -143.72, 107.55 -61.84, -34.25 277.42, 87.13 55.65, -120.32 in-in in 7.584 Saltbr-in 2.914 HRD-in -94.7, -57.23 78.86, -11.11 in-out-in SNCioi out-in ActLoopNT-out 16.565 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.01, 114.08 APE9-dihe-in -124.4, 147.41 APE8-dihe-in -79.65, 63.41 APE8-rot-na 32.33 APE67-dihe-in -69.55, -12.31 -53.55, -35.42 APE12-dist-na 16.044 APE11-dist-na 13.431 APE10-dist-na 11.456 APE9-dist-in 7.976 E990V None None XRAY 2.03 0.178 0.23 A 353 305 7 0 0 0 [[834, 1162]] 1.0 4asd TYR_KDR_HUMAN TYR 6e-100 339.8 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
4ASEA 807 1169 1356.0 AV9:3169 Type2 Inactive DFGout 15.508 9.621 BBAminus -131.22, 172.65 -143.22, 109.66 -69.47, -29.54 275.37, 90.83 50.61, -120.83 in-in in 7.684 Saltbr-in 3.052 HRD-in -82.51, -52.61 76.99, -4.03 in-out-in SNCioi out-in ActLoopNT-out 16.451 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.53, 119.23 APE9-dihe-in -120.88, 143.86 APE8-dihe-in -75.11, 65.17 APE8-rot-na 28.66 APE67-dihe-in -64.27, -9.66 -54.44, -43.05 APE12-dist-na 16.155 APE11-dist-na 13.798 APE10-dist-na 11.652 APE9-dist-in 7.975 E990V None None XRAY 1.83 0.207 0.231 A 353 307 6 0 0 0 [[834, 1162]] 1.0 4ase TYR_KDR_HUMAN TYR 6e-100 339.8 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3VHEA 811 1169 1356.0 42Q:1170 Type2 Inactive DFGout 15.985 10.209 BBAminus -150.75, 179.81 -145.06, 104.72 -59.59, -35.08 275.44, 63.4 53.57, -124.69 in-in in 7.546 Saltbr-in 2.811 HRD-in -83.47, -54.75 79.34, -6.09 in-out-out SNCioo out-out ActLoopNT-out 16.706 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -104.74, 113.79 APE9-dihe-in -123.79, 149.45 APE8-dihe-in -81.9, 62.59 APE8-rot-na 35.67 APE67-dihe-in -65.86, -15.29 -45.47, -41.75 APE12-dist-na 999.0 APE11-dist-na 15.555 APE10-dist-na 11.557 APE9-dist-out 8.043 None None None XRAY 1.55 0.186 0.209 A 359 303 56 0 0 2 [[834, 1162]] 1.0 3vhe TYR_KDR_HUMAN TYR 2.4e-99 337.8 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3VHKA 814 1168 1356.0 BPK:2001 Type2 Inactive DFGout 16.497 9.97 BBAminus -142.42, -168.12 -154.13, 113.05 -66.9, -34.19 279.52, 80.67 55.02, -115.26 in-in in 7.732 Saltbr-in 2.685 HRD-in -85.63, -50.5 78.47, -9.06 in-out-out SNCioo out-out ActLoopNT-out 16.634 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -101.84, 113.0 APE9-dihe-in -119.22, 139.89 APE8-dihe-in -75.91, 70.12 APE8-rot-na 29.63 APE67-dihe-in -67.23, -15.54 -56.62, -35.16 APE12-dist-na 999.0 APE11-dist-na 13.376 APE10-dist-na 11.003 APE9-dist-out 8.108 None None None XRAY 2.49 0.21 0.262 A 368 297 58 0 0 2 [[834, 1162]] 1.0 3vhk TYR_KDR_HUMAN TYR 2.6e-99 337.7 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
2QU5A 816 1170 1356.0 276:501 Type2 Inactive DFGout 15.957 9.83 BBAminus -148.46, -172.65 -150.45, 108.8 -78.65, -16.42 280.25, 86.88 -99.11, -166.35 in-in in 7.874 Saltbr-in 2.752 HRD-in -80.82, -52.31 94.02, -25.74 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -87.63, 5.51 APE9-dihe-out 37.61, 55.41 APE8-dihe-out -52.54, -22.13 APE8-rot-na 25.49 APE67-dihe-in -67.04, -17.69 -59.89, -24.68 APE12-dist-na 10.279 APE11-dist-na 14.224 APE10-dist-na 11.11 APE9-dist-out 11.322 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.95 0.213 0.251 A 314 292 13 0 0 13 [[834, 1162]] 1.0 2qu5 TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
2QU6A 817 1171 1356.0 857:60501 Type2 Inactive DFGout 15.942 9.817 BBAminus -132.31, -170.97 -155.67, 103.74 -71.24, -21.04 287.6, 86.95 -49.98, 999.0 in-in in 7.837 Saltbr-in 3.056 HRD-in -61.86, -49.75 81.1, -16.44 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 40.43 APE8-rot-na 31.68 APE67-dihe-in -68.37, -13.6 -54.82, -35.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.1 0.242 0.272 A 314 276 29 0 0 19 [[834, 1162]] 1.0 2qu6 TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
2RL5A 815 1171 1356.0 2RL:60501 Type2 Inactive DFGout 15.392 11.07 BBAminus -145.48, -175.23 -148.97, 113.05 -80.1, -11.01 289.69, 95.02 69.28, 57.0 in-in in 7.826 Saltbr-in 2.698 HRD-in -65.08, -49.32 80.71, -16.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -86.71, -13.59 APE9-dihe-out 45.53, 52.75 APE8-dihe-out -54.88, -21.97 APE8-rot-na 32.05 APE67-dihe-in -73.02, -12.93 -62.39, -23.08 APE12-dist-na 7.93 APE11-dist-na 10.632 APE10-dist-na 6.743 APE9-dist-out 11.661 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.65 0.199 0.233 A 314 290 17 0 0 14 [[834, 1162]] 1.0 2rl5 TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3B8QB 820 1166 1356.0 900:60502 Type2 Inactive DFGout 15.404 10.078 BBAminus -136.11, -171.43 -160.46, 118.31 -80.85, -45.83 290.91, 83.9 123.21, 999.0 in-in in 7.898 Saltbr-in 2.903 HRD-in -68.36, -46.63 75.78, -5.88 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 155.56 APE8-dihe-out -60.35, -14.62 APE8-rot-na 30.93 APE67-dihe-in -68.62, -6.92 -55.79, -32.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.297 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.75 0.218 0.276 B 314 271 26 0 0 18 [[834, 1162]] 1.0 3b8q TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3BE2A 815 1171 1356.0 RAJ:60501 Type2 Inactive DFGout 14.113 11.043 BBAminus -134.72, 177.84 -152.38, 97.13 -77.52, -8.1 302.77, 127.65 76.19, 999.0 in-in in 7.941 Saltbr-in 2.769 HRD-in -67.93, -53.26 79.3, -9.77 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 56.48 APE8-rot-na 341.32 APE67-dihe-in -65.72, -14.43 -46.07, -42.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 1.75 0.197 0.226 A 314 285 22 0 0 19 [[834, 1162]] 1.0 3be2 TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3CP9A 817 1171 1356.0 C19:60501 Type2 Inactive DFGout 16.62 10.275 BBAminus -128.38, -176.57 -155.05, 99.17 -63.66, -9.88 278.68, 88.56 -54.74, 999.0 in-in in 7.733 Saltbr-in 2.636 HRD-in -61.14, -53.92 79.09, -9.79 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 101.57 APE8-dihe-out -50.34, -15.58 APE8-rot-na 28.54 APE67-dihe-in -69.67, -13.51 -65.76, -26.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.578 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.5 0.211 0.263 A 314 281 24 0 0 18 [[834, 1162]] 1.0 3cp9 TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3CP9B 819 1165 1356.0 C19:60502 Type2 Inactive DFGout 16.841 10.404 BBAminus -132.75, -171.12 -162.18, 105.04 -62.12, -28.88 281.99, 80.12 49.45, -86.0 in-in in 7.646 Saltbr-in 3.048 HRD-in -88.31, -43.32 78.52, -15.92 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -57.69 APE8-dihe-out -39.24, -27.85 APE8-rot-na 24.86 APE67-dihe-in -68.9, -8.27 -59.68, -31.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.44 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.5 0.211 0.263 B 314 269 28 0 0 17 [[834, 1162]] 1.0 3cp9 TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3CPCB 820 1165 1356.0 C52:60002 Type2 Inactive DFGout 16.639 10.379 BBAminus -131.82, -178.95 -148.17, 107.11 -69.23, -53.88 273.75, 87.39 111.77, 999.0 in-in in 7.485 Saltbr-in 2.706 HRD-in -75.42, -46.4 80.7, -16.54 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -53.89 APE8-dihe-out -53.45, -16.48 APE8-rot-na 17.35 APE67-dihe-in -69.92, -17.21 -63.01, -26.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.384 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.4 0.221 0.272 B 314 262 34 0 0 18 [[834, 1162]] 1.0 3cpc TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3DTWB 820 1166 1356.0 A96:60502 Type2 Inactive DFGout 15.036 10.168 BBAminus -136.42, -166.86 -159.08, 106.24 -84.37, -81.02 295.18, 95.96 174.82, 139.27 in-in in 8.177 Saltbr-in 2.957 HRD-in -66.59, -51.66 77.85, -16.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, 31.74 APE9-dihe-out -53.82, -56.19 APE8-dihe-out -45.11, -17.45 APE8-rot-na 28.36 APE67-dihe-in -71.35, -4.04 -72.8, -21.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.291 APE9-dist-out 11.527 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.9 0.215 0.279 B 314 269 28 0 0 16 [[834, 1162]] 1.0 3dtw TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3EWHA 815 1171 1356.0 K11:60001 Type2 Inactive DFGout 15.139 11.42 BBAminus -133.49, -179.18 -135.71, 102.66 -69.48, -9.86 280.78, 102.57 67.93, 33.26 in-in in 7.937 Saltbr-in 3.079 HRD-in -71.49, -51.89 78.14, -10.7 in-out-none SNCion out-none ActLoopNT-out 12.944 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.93 APE8-dihe-in -76.46, 69.83 APE8-rot-na 30.0 APE67-dihe-in -66.36, -17.49 -56.88, -35.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.972 C817A,V916T,E990V None None XRAY 1.6 0.208 0.234 A 314 295 12 0 0 9 [[834, 1162]] 1.0 3ewh TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3U6JA 815 1171 1356.0 03X:60001 Type2 Inactive DFGout 14.979 10.356 BBAminus -144.73, -178.41 -146.44, 121.96 -64.93, -27.75 282.37, 79.48 52.91, -122.32 in-in in 7.455 Saltbr-in 2.867 HRD-in -74.57, -56.02 80.88, -14.69 in-out-in SNCioi out-in ActLoopNT-out 16.133 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.27, 117.84 APE9-dihe-in -122.3, 141.03 APE8-dihe-in -77.42, 64.76 APE8-rot-na 30.56 APE67-dihe-in -69.06, -14.4 -51.48, -37.1 APE12-dist-na 17.368 APE11-dist-na 14.214 APE10-dist-na 12.387 APE9-dist-in 7.733 V916T,E990V None None XRAY 2.15 0.196 0.23 A 314 305 2 0 0 0 [[834, 1162]] 1.0 3u6j TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3C7QA 819 1171 1356.0 XIN:1172 Type1 Inactive DFGout 15.785 9.794 None -118.96, 138.15 -110.64, 113.79 -73.47, 999.0 192.45, 128.99 999.0, 999.0 in-in in 7.283 Saltbr-in 2.608 HRD-in -83.9, -48.68 82.47, -6.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -147.17, 145.76 APE9-dihe-in -104.98, 98.81 APE8-dihe-out -50.37, -26.53 APE8-rot-na 330.15 APE67-dihe-in -62.19, -10.0 -56.65, -35.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.175 None PTR1054,PTR1059 CME862,CME1007,CME1024,PTR1054,PTR1059 XRAY 2.1 0.221 0.279 A 316 291 10 0 0 4 [[834, 1162]] 1.0 3c7q TYR_KDR_HUMAN TYR 3.9e-100 340.4 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
2P2IB 820 1168 1356.0 608:60502 Type1 Inactive DFGout 16.274 10.204 None -141.39, -171.24 -157.47, 119.0 -85.08, 999.0 285.18, 81.66 999.0, 999.0 in-in in 7.143 Saltbr-in 3.271 HRD-in -71.95, -45.89 71.89, -7.38 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 36.68 APE8-rot-na 31.31 APE67-dihe-in -54.41, -18.08 -58.67, -41.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C817A,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.4 0.222 0.266 B 314 263 36 0 0 20 [[834, 1162]] 1.0 2p2i TYR_KDR_HUMAN TYR 4e-100 340.4 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3VNTA 812 1168 1356.0 0JA:2001 Type2 Inactive DFGout 16.764 8.386 None -132.49, -178.83 -142.53, 104.52 -68.92, -32.97 219.02, 49.93 58.07, -122.23 in-in in 7.468 Saltbr-in 2.746 HRD-in -79.08, -51.8 75.79, -7.69 in-out-in SNCioi out-in ActLoopNT-out 16.542 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.01, 111.64 APE9-dihe-in -121.89, 148.7 APE8-dihe-in -79.2, 68.13 APE8-rot-na 30.95 APE67-dihe-in -64.82, -12.79 -56.01, -39.41 APE12-dist-na 16.826 APE11-dist-na 13.454 APE10-dist-na 11.292 APE9-dist-in 7.869 None None None XRAY 1.64 0.153 0.192 A 318 301 6 0 0 0 [[834, 1162]] 1.0 3vnt TYR_KDR_HUMAN TYR 4.2e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3VO3A 812 1168 1356.0 0KF:2001 Type2 Inactive DFGout 16.448 8.215 None -125.16, 179.81 -141.05, 99.79 -70.03, -34.74 215.55, 55.41 59.77, -120.61 in-in in 7.357 Saltbr-in 2.898 HRD-in -84.45, -53.71 76.95, -3.4 in-out-in SNCioi out-in ActLoopNT-out 16.477 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.91, 109.54 APE9-dihe-in -120.7, 147.5 APE8-dihe-in -78.09, 65.8 APE8-rot-na 32.33 APE67-dihe-in -67.73, -12.3 -53.4, -39.21 APE12-dist-na 17.03 APE11-dist-na 14.067 APE10-dist-na 11.393 APE9-dist-in 7.997 None None None XRAY 1.52 0.162 0.182 A 318 303 4 0 0 0 [[834, 1162]] 1.0 3vo3 TYR_KDR_HUMAN TYR 4.2e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
2QU6B 822 1165 1356.0 857:60502 Type2 Inactive DFGout 15.963 9.541 None -133.96, -169.17 -160.0, 100.56 -72.82, 999.0 288.62, 90.71 999.0, 999.0 in-in in 7.953 Saltbr-in 3.095 HRD-in -62.66, -51.11 76.69, -2.42 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.74 APE8-dihe-in -72.44, 73.71 APE8-rot-na 32.18 APE67-dihe-in -66.59, -17.43 -56.47, -30.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.292 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.1 0.242 0.272 B 314 260 34 0 0 19 [[834, 1162]] 1.0 2qu6 TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3B8QA 818 1171 1356.0 900:60501 Type2 Inactive DFGout 15.467 9.913 None -131.74, -168.2 -159.75, 118.5 -86.72, 999.0 284.22, 100.5 999.0, 999.0 in-in in 7.759 Saltbr-in 2.765 HRD-in -57.53, -50.67 79.88, -14.29 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 160.03 APE8-dihe-out -77.48, -12.97 APE8-rot-na 36.4 APE67-dihe-in -68.93, -8.62 -57.21, -28.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.072 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.75 0.218 0.276 A 314 285 19 0 0 19 [[834, 1162]] 1.0 3b8q TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3CPBA 819 1171 1356.0 C92:60001 Type2 Inactive DFGout 15.333 9.751 None -143.96, -172.89 -147.19, 119.38 -89.94, 999.0 278.49, 101.53 999.0, 999.0 in-in in 7.763 Saltbr-in 3.585 HRD-in -60.85, -44.16 62.59, 3.77 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.93 APE8-dihe-out -45.12, -28.83 APE8-rot-na 328.95 APE67-dihe-in -65.36, -7.17 -53.29, -33.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.351 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.7 0.224 0.286 A 314 278 25 0 0 19 [[834, 1162]] 1.0 3cpb TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3CPCA 820 1171 1356.0 C52:60001 Type2 Inactive DFGout 16.803 10.382 None -127.27, -176.88 -144.84, 92.18 -66.45, 999.0 268.44, 99.63 999.0, 999.0 in-out in 8.027 Saltbr-out 3.977 HRD-in -74.56, -44.56 79.03, -21.68 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.84 APE8-dihe-out -45.97, -30.08 APE8-rot-na 328.28 APE67-dihe-in -73.13, -9.14 -56.02, -29.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.356 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.4 0.221 0.272 A 314 277 25 0 0 19 [[834, 1162]] 1.0 3cpc TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3DTWA 818 1171 1356.0 A96:60501 Type2 Inactive DFGout 15.158 10.099 None -129.54, -170.94 -153.49, 103.32 -82.68, 999.0 294.21, 96.03 999.0, 999.0 in-in in 8.006 Saltbr-in 2.64 HRD-in -53.04, -53.77 79.82, -12.25 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.1 APE8-dihe-out -46.34, -20.16 APE8-rot-na 23.94 APE67-dihe-in -60.71, -7.92 -57.08, -38.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.234 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.9 0.215 0.279 A 314 281 23 0 0 19 [[834, 1162]] 1.0 3dtw TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3CJFA 817 1168 1356.0 SAV:61167 Type1 Inactive None 999.0 999.0 None -83.44, 111.78 -118.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 7.821 Saltbr-out 5.223 HRD-out -105.6, 121.11 -71.37, -10.71 out-in-none SNCoin in-none ActLoopNT-in 2.889 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 48.59 APE8-rot-na 25.36 APE67-dihe-in -69.88, -14.36 -60.34, -37.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None CSO862,CSO1007,CSO1024,CSO1045,CSO1116 XRAY 2.15 0.205 0.258 A 309 281 17 0 0 14 [[834, 1162]] 1.0 3cjf TYR_KDR_HUMAN TYR 4.8e-100 340.1 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
1YWNA 820 1171 1356.0 LIF:60301 Type1 Inactive None 999.0 999.0 None -128.91, 171.96 -143.62, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.21 Saltbr-in 2.725 HRD-in -77.88, -50.07 82.87, -17.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -141.39, 161.44 APE9-dihe-in -104.18, 100.32 APE8-dihe-out -56.09, -24.71 APE8-rot-na 336.02 APE67-dihe-in -70.59, -14.0 -51.58, -32.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.239 E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 1.71 0.206 0.23 A 316 281 21 0 0 6 [[834, 1162]] 1.0 1ywn TYR_KDR_HUMAN TYR 4.1e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
3VIDA 813 1168 1356.0 4TT:2001 Type1 Inactive None 999.0 999.0 None -128.64, 167.68 -132.79, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.326 Saltbr-in 2.98 HRD-in -77.53, -50.55 79.3, -13.28 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -152.12, 159.09 APE9-dihe-in -96.12, 109.5 APE8-dihe-out -66.36, -14.96 APE8-rot-na 337.32 APE67-dihe-in -69.61, -3.71 -60.46, -30.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.378 None None None XRAY 2.3 0.247 0.281 A 356 299 57 0 0 7 [[834, 1162]] 1.0 3vid TYR_KDR_HUMAN TYR 2.3e-99 337.8 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2

TYR_KDR (Vascular endothelial growth factor receptor 2)

Total number of chains: 54
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 32 59.3% 6GQQA
DFGout None 9 16.7% 3VO3A
DFGin BLAminus 3 5.6% AF-P35968-K1A
DFGin BLBplus 3 5.6% 3WZDA
None None 3 5.6% 3CJFA
DFGinter None 2 3.7% 1Y6BA
DFGin BLAplus 1 1.9% 2P2HA
DFGin None 1 1.9% 1VR2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
VGFR2_HUMAN AF-P35968-K1A P35968 826 1170 1356.0 No_ligand No_ligand Active DFGin 6.724 13.754 BLAminus -135.49, -178.07 64.31, 58.61 -79.84, 14.65 291.25, 84.84 -59.67, -29.27 in-in in 7.274 Saltbr-in 2.654 HRD-in -79.81, -44.23 66.36, -15.09 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.88, 109.91 APE9-dihe-in -121.83, 150.33 APE8-dihe-in -76.73, 95.83 APE8-rot-na 34.09 APE67-dihe-in -64.1, -25.24 -52.96, -31.45 APE12-dist-na 14.175 APE11-dist-na 7.936 APE10-dist-na 10.731 APE9-dist-in 6.196 None None None AF2 -1.0 1.0 1.0 A 345 345 0 0 0 0 [[834, 1162]] 1.0 AF-P35968-K1 Homo sapiens TYR_KDR_HUMAN TYR 2.1e-99 338.0 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN AF-P35968-K3A P35968 826 1170 1356.0 No_ligand No_ligand Active DFGin 6.467 13.46 BLAminus -139.09, -177.77 61.66, 65.38 -79.85, 17.72 289.99, 89.58 -61.52, -31.06 in-in in 7.822 Saltbr-in 2.729 HRD-in -81.16, -45.43 63.07, 4.14 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -52.76, 130.74 APE9-dihe-in -112.3, 130.74 APE8-dihe-in -82.3, 61.23 APE8-rot-na 36.08 APE67-dihe-in -68.73, -19.78 -48.02, -36.64 APE12-dist-na 13.331 APE11-dist-na 7.163 APE10-dist-na 8.538 APE9-dist-in 6.757 None None None AF2 -1.0 1.0 1.0 A 345 345 0 0 0 0 [[834, 1162]] 1.0 AF-P35968-K3 Homo sapiens TYR_KDR_HUMAN TYR 2.1e-99 338.0 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3CJGA P35968 816 1168 1356.0 KIM:61167 Type1 Inactive DFGin 7.412 14.128 BLAminus -120.91, -162.35 48.63, 86.88 -107.47, 22.59 302.68, 92.72 -76.12, -15.36 in-in in 7.179 Saltbr-in 2.681 HRD-in -77.13, -50.16 74.93, 1.17 in-in-out SNCiio in-out ActLoopNT-in 2.977 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 19.76 APE8-rot-na 1.33 APE67-dihe-out -66.63, -12.94 74.8, -54.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None CSO862,CSO1024 XRAY 2.25 0.209 0.253 A 309 282 17 0 0 14 [[834, 1162]] 1.0 3cjg Homo sapiens TYR_KDR_HUMAN TYR 4.8e-100 340.1 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 2P2HA P35968 815 1172 1356.0 994:60501 Type1 Inactive DFGin 5.778 13.494 BLAplus -120.41, 168.7 57.61, 43.27 -102.94, -14.81 60.29, 84.2 -108.45, 28.25 in-in in 7.35 Saltbr-in 2.527 HRD-in -63.68, -53.12 82.34, -19.49 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, 158.7 APE9-dihe-out 54.03, 51.67 APE8-dihe-out -62.29, -19.22 APE8-rot-na 32.86 APE67-dihe-in -68.4, -12.54 -60.9, -27.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 19.04 APE9-dist-out 11.181 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 1.95 0.205 0.229 A 314 289 19 0 0 15 [[834, 1162]] 1.0 2p2h Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3WZDA P35968 820 1167 1356.0 LEV:1201 Type1 Inactive DFGin 5.426 13.803 BLBplus -131.31, 171.12 64.88, 24.46 -69.96, 136.97 45.36, 91.24 79.76, 6.08 in-in in 7.309 Saltbr-in 2.943 HRD-in -65.52, -53.13 82.13, -20.42 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -70.62 APE8-dihe-out -53.22, -31.36 APE8-rot-na 22.8 APE67-dihe-in -66.02, -15.12 -58.21, -29.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.248 T940V None None XRAY 1.57 0.184 0.212 A 309 278 20 0 0 16 [[834, 1162]] 1.0 3wzd Homo sapiens TYR_KDR_HUMAN TYR 3.7e-100 340.4 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3B8RA P35968 818 1171 1356.0 887:60201 Type1 Inactive DFGin 5.424 13.871 BLBplus -147.04, 169.16 57.66, 43.33 -97.43, 156.79 47.05, 78.4 59.04, 37.41 in-in in 7.251 Saltbr-in 2.68 HRD-in -59.31, -52.93 80.34, -8.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 162.25 APE8-dihe-out -73.03, -9.68 APE8-rot-na 326.59 APE67-dihe-in -61.58, -18.77 -55.36, -31.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.259 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.7 0.204 0.259 A 314 282 22 0 0 17 [[834, 1162]] 1.0 3b8r Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3B8RB P35968 821 1166 1356.0 887:60202 Type1 Inactive DFGin 5.442 13.886 BLBplus -153.23, 176.22 49.55, 49.42 -108.14, 150.46 48.31, 72.77 69.58, 35.57 in-in in 7.393 Saltbr-in 2.745 HRD-in -68.34, -51.75 79.37, -8.5 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.55 APE8-dihe-out -62.02, -11.57 APE8-rot-na 326.58 APE67-dihe-in -65.24, -19.42 -57.92, -26.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.261 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.7 0.204 0.259 B 314 267 29 0 0 17 [[834, 1162]] 1.0 3b8r Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 1VR2A P35968 820 1168 1356.0 No_ligand No_ligand Inactive DFGin 6.197 12.201 None -132.36, 167.84 67.89, 27.54 -86.08, 999.0 49.78, 130.84 999.0, 999.0 in-in in 7.73 Saltbr-in 2.99 HRD-in -66.37, -43.4 76.06, -15.34 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -137.43, 155.04 APE9-dihe-in -108.73, 90.95 APE8-dihe-out -47.33, -14.52 APE8-rot-na 323.83 APE67-dihe-in -64.29, -7.8 -69.97, -29.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.466 E990V PTR1059 PTR1059 XRAY 2.4 0.215 999.0 A 316 275 24 0 0 16 [[834, 1162]] 1.0 1vr2 Homo sapiens TYR_KDR_HUMAN TYR 4.1e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 1Y6AA P35968 820 1167 1356.0 AAZ:60201 Type1 Inactive DFGinter 8.666 8.838 None -73.14, 116.72 -103.71, 73.1 -178.89, 999.0 25.84, 61.42 999.0, 999.0 in-in in 7.47 Saltbr-in 2.801 HRD-in -83.04, -53.13 81.96, -16.64 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -20.95 APE8-rot-na 328.99 APE67-dihe-in -63.85, -16.51 -63.27, -26.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.196 0.217 A 366 261 87 0 0 20 [[834, 1162]] 1.0 1y6a Homo sapiens TYR_KDR_HUMAN TYR 2.6e-99 337.7 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 1Y6BA P35968 819 1168 1356.0 AAX:60201 Type1 Inactive DFGinter 8.959 8.691 None -70.35, 112.74 -90.68, -29.02 -42.32, 999.0 351.89, 106.67 999.0, 999.0 in-in in 7.482 Saltbr-in 2.957 HRD-in -82.96, -58.21 87.46, -12.31 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 69.65 APE8-rot-na 33.76 APE67-dihe-in -65.54, -15.03 -63.36, -37.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.194 0.236 A 366 266 84 0 0 20 [[834, 1162]] 1.0 1y6b Homo sapiens TYR_KDR_HUMAN TYR 2.6e-99 337.7 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 4AG8A P35968 816 1168 1356.0 AXI:2000 Type1 Inactive DFGout 16.497 10.362 BBAminus -143.7, -179.58 -144.17, 113.57 -60.35, -33.13 275.19, 77.68 54.27, -121.79 in-in in 7.519 Saltbr-in 2.748 HRD-in -80.25, -53.16 76.08, -12.6 in-out-in SNCioi out-in ActLoopNT-out 16.566 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.55, 111.08 APE9-dihe-in -116.46, 147.01 APE8-dihe-in -77.77, 66.25 APE8-rot-na 30.85 APE67-dihe-in -66.26, -17.06 -55.96, -37.76 APE12-dist-na 16.456 APE11-dist-na 13.513 APE10-dist-na 11.473 APE9-dist-in 7.983 E990V None None XRAY 1.95 0.197 0.241 A 316 296 7 0 0 0 [[834, 1162]] 1.0 4ag8 Homo sapiens TYR_KDR_HUMAN TYR 4.1e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 4AGDA P35968 802 1169 1356.0 B49:2000 Type1 Inactive DFGout 16.069 10.723 BBAminus -138.96, 169.29 -127.17, 103.68 -55.8, -25.22 266.19, 75.17 52.13, -127.76 in-in in 6.778 Saltbr-in 3.023 HRD-out -100.33, 104.42 -84.72, 20.62 in-out-in SNCioi out-in ActLoopNT-out 15.854 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.84, 115.98 APE9-dihe-in -119.8, 140.98 APE8-dihe-in -66.9, 64.41 APE8-rot-na 27.14 APE67-dihe-in -54.0, -28.9 -62.45, -38.96 APE12-dist-na 16.473 APE11-dist-na 15.651 APE10-dist-na 13.29 APE9-dist-in 7.777 E990V None None XRAY 2.81 0.21 0.307 A 353 304 7 0 0 0 [[834, 1162]] 1.0 4agd Homo sapiens TYR_KDR_HUMAN TYR 6e-100 339.8 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3CPBB P35968 820 1165 1356.0 C92:60002 Type1 Inactive DFGout 15.47 9.898 BBAminus -145.95, -173.33 -148.66, 122.86 -90.71, -55.39 280.65, 93.5 148.13, 999.0 in-in in 7.466 Saltbr-in 2.743 HRD-in -84.85, -49.1 84.19, -23.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -49.62 APE8-dihe-out -64.93, -12.78 APE8-rot-na 24.8 APE67-dihe-in -63.19, -14.98 -60.0, -29.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.363 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.7 0.224 0.286 B 314 263 33 0 0 18 [[834, 1162]] 1.0 3cpb Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 2XIRA P35968 816 1168 1356.0 00J:2169 Type1.5_Back Inactive DFGout 15.972 9.922 BBAminus -148.97, -178.6 -143.75, 112.04 -61.18, -32.48 278.24, 81.67 54.1, -120.79 in-in in 7.693 Saltbr-in 2.739 HRD-in -84.85, -55.21 79.77, -10.15 in-out-in SNCioi out-in ActLoopNT-out 16.772 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.39, 115.13 APE9-dihe-in -121.67, 148.38 APE8-dihe-in -77.59, 66.04 APE8-rot-na 29.49 APE67-dihe-in -66.29, -14.94 -52.56, -39.25 APE12-dist-na 16.968 APE11-dist-na 13.328 APE10-dist-na 11.46 APE9-dist-in 7.91 E990V None None XRAY 1.5 0.219 0.238 A 316 296 7 0 0 0 [[834, 1162]] 1.0 2xir Homo sapiens TYR_KDR_HUMAN TYR 4.1e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 4AGCA P35968 801 1169 1356.0 AXI:2000 Type1.5_Back Inactive DFGout 16.342 10.451 BBAminus -142.09, -174.91 -148.19, 116.12 -63.13, -37.04 279.42, 73.43 58.39, -117.25 in-in in 7.347 Saltbr-in 2.669 HRD-out -119.32, 107.11 -77.42, 1.81 in-out-in SNCioi out-in ActLoopNT-out 16.525 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.04, 119.4 APE9-dihe-in -126.34, 146.64 APE8-dihe-in -75.44, 63.67 APE8-rot-na 28.57 APE67-dihe-in -65.72, -15.94 -53.26, -41.15 APE12-dist-na 16.758 APE11-dist-na 14.426 APE10-dist-na 12.23 APE9-dist-in 7.621 E990V None None XRAY 2.0 0.204 0.251 A 353 305 7 0 0 0 [[834, 1162]] 1.0 4agc Homo sapiens TYR_KDR_HUMAN TYR 6e-100 339.8 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3WZEA P35968 815 1167 1356.0 BAX:1201 Type2 Inactive DFGout 15.423 9.724 BBAminus -149.68, 178.07 -142.38, 105.98 -66.68, -30.19 278.49, 88.73 48.89, -116.05 in-in in 7.489 Saltbr-in 2.791 HRD-in -80.41, -52.96 79.37, -11.85 in-out-out SNCioo out-out ActLoopNT-out 16.658 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -114.24, 115.23 APE9-dihe-in -125.6, 147.79 APE8-dihe-in -77.19, 70.99 APE8-rot-na 33.48 APE67-dihe-in -66.14, -18.73 -60.64, -36.14 APE12-dist-na 999.0 APE11-dist-na 13.7 APE10-dist-na 11.342 APE9-dist-out 8.081 T940V None None XRAY 1.9 0.188 0.224 A 309 298 5 0 0 1 [[834, 1162]] 1.0 3wze Homo sapiens TYR_KDR_HUMAN TYR 3.7e-100 340.4 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 2OH4A P35968 816 1171 1356.0 GIG:60303 Type2 Inactive DFGout 15.031 10.896 BBAminus -143.49, 178.34 -145.54, 97.19 -58.33, -39.73 283.57, 84.4 57.49, 37.59 in-in in 7.356 Saltbr-in 2.634 HRD-in -73.75, -53.05 85.59, -23.47 in-out-out SNCioo out-out ActLoopNT-out 17.855 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -140.49, 159.6 APE9-dihe-in -103.67, 100.95 APE8-dihe-out -54.41, -26.49 APE8-rot-na 335.24 APE67-dihe-in -67.64, -14.75 -51.43, -34.8 APE12-dist-na 13.307 APE11-dist-na 12.794 APE10-dist-na 13.546 APE9-dist-out 11.206 None PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.05 0.189 0.231 A 316 299 6 0 0 0 [[834, 1162]] 1.0 2oh4 Homo sapiens TYR_KDR_HUMAN TYR 5.6e-100 339.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 2P2IA P35968 817 1172 1356.0 608:60501 Type2 Inactive DFGout 16.646 10.42 BBAminus -140.93, -165.49 -165.76, 112.99 -76.4, -20.94 281.97, 76.28 -89.36, -168.3 in-in in 7.487 Saltbr-in 2.878 HRD-in -67.84, -45.58 77.98, -15.16 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.47 APE8-dihe-in -74.22, 56.93 APE8-rot-na 34.49 APE67-dihe-in -67.46, -12.22 -54.19, -35.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.65 C817A,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.4 0.222 0.266 A 314 283 23 0 0 16 [[834, 1162]] 1.0 2p2i Homo sapiens TYR_KDR_HUMAN TYR 4e-100 340.4 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3EFLA P35968 817 1171 1356.0 706:60501 Type2 Inactive DFGout 16.18 10.559 BBAminus -138.71, -172.72 -156.17, 97.27 -59.6, -16.87 285.84, 75.59 69.09, 999.0 in-in in 7.333 Saltbr-in 2.822 HRD-in -65.88, -53.9 89.41, -28.23 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 54.05 APE8-rot-na 34.8 APE67-dihe-in -59.53, -20.45 -52.35, -30.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C817A,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.2 0.23 0.264 A 314 279 26 0 0 19 [[834, 1162]] 1.0 3efl Homo sapiens TYR_KDR_HUMAN TYR 4e-100 340.4 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3EFLB P35968 821 1165 1356.0 706:60502 Type2 Inactive DFGout 16.113 10.23 BBAminus -141.16, -175.15 -153.12, 108.94 -69.6, -34.74 280.14, 78.23 138.83, 999.0 in-in in 7.096 Saltbr-in 3.242 HRD-in -62.3, -53.81 81.7, -4.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.71 APE8-dihe-out -39.02, -20.75 APE8-rot-na 27.77 APE67-dihe-in -68.47, -11.11 -59.68, -39.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.82 C817A,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.2 0.23 0.264 B 314 263 32 0 0 18 [[834, 1162]] 1.0 3efl Homo sapiens TYR_KDR_HUMAN TYR 4e-100 340.4 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 5EW3A P35968 821 1168 1356.0 5T2:1201 Type2 Inactive DFGout 15.88 10.082 BBAminus -139.44, -178.76 -147.6, 111.79 -72.49, -35.99 276.01, 89.46 -76.06, 999.0 in-in in 7.423 Saltbr-in 2.964 HRD-in -64.57, -50.86 83.75, -23.1 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -57.13 APE8-dihe-in -81.64, 66.53 APE8-rot-na 27.98 APE67-dihe-in -64.62, -30.42 -51.68, -35.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.717 None None None XRAY 2.5 0.219 0.254 A 316 274 24 0 0 18 [[834, 1162]] 1.0 5ew3 Homo sapiens TYR_KDR_HUMAN TYR 4.1e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 5EW3B P35968 820 1165 1356.0 5T2:1201 Type2 Inactive DFGout 15.862 10.107 BBAminus -138.44, -179.7 -148.59, 111.71 -71.05, -37.05 275.98, 95.16 -74.59, 999.0 in-in in 7.217 Saltbr-in 2.905 HRD-in -64.78, -51.26 84.58, -25.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.03 APE8-dihe-in -87.05, 66.83 APE8-rot-na 29.69 APE67-dihe-in -64.72, -30.16 -52.26, -35.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.665 None None None XRAY 2.5 0.219 0.254 B 316 266 30 0 0 18 [[834, 1162]] 1.0 5ew3 Homo sapiens TYR_KDR_HUMAN TYR 4.1e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 6GQOA P35968 811 1168 1356.0 F82:61201 Type2 Inactive DFGout 15.51 9.872 BBAminus -137.41, -174.48 -148.75, 103.09 -62.92, -33.23 281.85, 85.18 53.53, -124.22 in-in in 7.652 Saltbr-in 2.842 HRD-in -77.93, -60.11 81.09, -6.45 in-out-in SNCioi out-in ActLoopNT-out 16.478 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.71, 109.7 APE9-dihe-in -116.16, 147.79 APE8-dihe-in -80.04, 70.94 APE8-rot-na 31.31 APE67-dihe-in -64.81, -13.7 -51.33, -43.39 APE12-dist-na 16.398 APE11-dist-na 13.212 APE10-dist-na 11.091 APE9-dist-in 7.951 None None None XRAY 1.87 0.174 0.207 A 322 307 0 0 0 0 [[834, 1162]] 1.0 6gqo Homo sapiens TYR_KDR_HUMAN TYR 4.4e-100 340.2 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 6GQPA P35968 821 1168 1356.0 F88:61201 Type2 Inactive DFGout 16.041 9.828 BBAminus -137.29, -179.39 -147.6, 105.82 -66.11, -30.27 279.44, 81.63 58.93, -133.79 in-in in 7.784 Saltbr-in 3.16 HRD-in -72.29, -59.65 82.33, -13.78 in-out-out SNCioo out-out ActLoopNT-out 16.787 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -109.31, 108.64 APE9-dihe-in -119.08, 147.18 APE8-dihe-in -76.82, 68.93 APE8-rot-na 29.84 APE67-dihe-in -64.0, -17.44 -48.7, -44.35 APE12-dist-na 16.28 APE11-dist-na 13.029 APE10-dist-na 10.463 APE9-dist-out 8.02 None None None XRAY 2.09 0.201 0.234 A 322 298 0 0 0 0 [[834, 1162]] 1.0 6gqp Homo sapiens TYR_KDR_HUMAN TYR 4.4e-100 340.2 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 6GQQA P35968 813 1167 1356.0 F8B:61201 Type2 Inactive DFGout 16.318 9.893 BBAminus -140.35, 179.68 -146.82, 105.0 -62.58, -33.91 278.73, 81.84 52.08, -122.03 in-in in 7.855 Saltbr-in 2.87 HRD-in -79.41, -58.06 81.99, -7.96 in-out-out SNCioo out-out ActLoopNT-out 16.642 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -102.87, 113.66 APE9-dihe-in -116.65, 151.24 APE8-dihe-in -82.45, 66.44 APE8-rot-na 31.58 APE67-dihe-in -64.76, -12.48 -47.19, -45.1 APE12-dist-na 16.867 APE11-dist-na 13.207 APE10-dist-na 11.633 APE9-dist-out 8.047 None None None XRAY 1.52 0.178 0.204 A 322 304 0 0 0 0 [[834, 1162]] 1.0 6gqq Homo sapiens TYR_KDR_HUMAN TYR 4.4e-100 340.2 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 6XVJA P35968 813 1167 1356.0 O35:1201 Type2 Inactive DFGout 15.797 9.86 BBAminus -132.46, -168.17 -160.35, 90.75 -54.1, -41.9 283.85, 84.23 55.21, -117.78 in-in in 7.713 Saltbr-in 2.862 HRD-in -84.82, -59.51 82.99, -12.32 in-out-in SNCioi out-in ActLoopNT-out 16.682 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.56, 109.17 APE9-dihe-in -116.73, 149.21 APE8-dihe-in -78.94, 66.26 APE8-rot-na 30.73 APE67-dihe-in -62.92, -14.21 -46.08, -45.25 APE12-dist-na 17.103 APE11-dist-na 13.504 APE10-dist-na 11.345 APE9-dist-in 7.992 E990V None None XRAY 1.78 0.18 0.215 A 322 305 0 0 0 0 [[834, 1162]] 1.0 6xvj Homo sapiens TYR_KDR_HUMAN TYR 4.4e-100 340.2 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 6XVKA P35968 821 1168 1356.0 O3E:1201 Type2 Inactive DFGout 16.107 9.975 BBAminus -141.36, -173.76 -156.84, 95.12 -54.67, -41.12 280.3, 80.99 54.89, -110.87 in-in in 7.682 Saltbr-in 2.816 HRD-in -73.74, -55.3 80.84, -9.06 in-out-in SNCioi out-in ActLoopNT-out 16.606 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.81, 104.06 APE9-dihe-in -104.53, 149.15 APE8-dihe-in -78.71, 70.31 APE8-rot-na 29.7 APE67-dihe-in -63.75, -14.49 -47.12, -46.79 APE12-dist-na 16.777 APE11-dist-na 12.961 APE10-dist-na 11.381 APE9-dist-in 7.676 E990V None None XRAY 1.99 0.208 0.244 A 322 298 0 0 0 0 [[834, 1162]] 1.0 6xvk Homo sapiens TYR_KDR_HUMAN TYR 4.4e-100 340.2 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 4ASDA P35968 807 1168 1356.0 BAX:1500 Type2 Inactive DFGout 15.598 9.565 BBAminus -143.46, -179.3 -143.72, 107.55 -61.84, -34.25 277.42, 87.13 55.65, -120.32 in-in in 7.584 Saltbr-in 2.914 HRD-in -94.7, -57.23 78.86, -11.11 in-out-in SNCioi out-in ActLoopNT-out 16.565 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.01, 114.08 APE9-dihe-in -124.4, 147.41 APE8-dihe-in -79.65, 63.41 APE8-rot-na 32.33 APE67-dihe-in -69.55, -12.31 -53.55, -35.42 APE12-dist-na 16.044 APE11-dist-na 13.431 APE10-dist-na 11.456 APE9-dist-in 7.976 E990V None None XRAY 2.03 0.178 0.23 A 353 305 7 0 0 0 [[834, 1162]] 1.0 4asd Homo sapiens TYR_KDR_HUMAN TYR 6e-100 339.8 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 4ASEA P35968 807 1169 1356.0 AV9:3169 Type2 Inactive DFGout 15.508 9.621 BBAminus -131.22, 172.65 -143.22, 109.66 -69.47, -29.54 275.37, 90.83 50.61, -120.83 in-in in 7.684 Saltbr-in 3.052 HRD-in -82.51, -52.61 76.99, -4.03 in-out-in SNCioi out-in ActLoopNT-out 16.451 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.53, 119.23 APE9-dihe-in -120.88, 143.86 APE8-dihe-in -75.11, 65.17 APE8-rot-na 28.66 APE67-dihe-in -64.27, -9.66 -54.44, -43.05 APE12-dist-na 16.155 APE11-dist-na 13.798 APE10-dist-na 11.652 APE9-dist-in 7.975 E990V None None XRAY 1.83 0.207 0.231 A 353 307 6 0 0 0 [[834, 1162]] 1.0 4ase Homo sapiens TYR_KDR_HUMAN TYR 6e-100 339.8 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3VHEA P35968 811 1169 1356.0 42Q:1170 Type2 Inactive DFGout 15.985 10.209 BBAminus -150.75, 179.81 -145.06, 104.72 -59.59, -35.08 275.44, 63.4 53.57, -124.69 in-in in 7.546 Saltbr-in 2.811 HRD-in -83.47, -54.75 79.34, -6.09 in-out-out SNCioo out-out ActLoopNT-out 16.706 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -104.74, 113.79 APE9-dihe-in -123.79, 149.45 APE8-dihe-in -81.9, 62.59 APE8-rot-na 35.67 APE67-dihe-in -65.86, -15.29 -45.47, -41.75 APE12-dist-na 999.0 APE11-dist-na 15.555 APE10-dist-na 11.557 APE9-dist-out 8.043 None None None XRAY 1.55 0.186 0.209 A 359 303 56 0 0 2 [[834, 1162]] 1.0 3vhe Homo sapiens TYR_KDR_HUMAN TYR 2.4e-99 337.8 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3VHKA P35968 814 1168 1356.0 BPK:2001 Type2 Inactive DFGout 16.497 9.97 BBAminus -142.42, -168.12 -154.13, 113.05 -66.9, -34.19 279.52, 80.67 55.02, -115.26 in-in in 7.732 Saltbr-in 2.685 HRD-in -85.63, -50.5 78.47, -9.06 in-out-out SNCioo out-out ActLoopNT-out 16.634 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -101.84, 113.0 APE9-dihe-in -119.22, 139.89 APE8-dihe-in -75.91, 70.12 APE8-rot-na 29.63 APE67-dihe-in -67.23, -15.54 -56.62, -35.16 APE12-dist-na 999.0 APE11-dist-na 13.376 APE10-dist-na 11.003 APE9-dist-out 8.108 None None None XRAY 2.49 0.21 0.262 A 368 297 58 0 0 2 [[834, 1162]] 1.0 3vhk Homo sapiens TYR_KDR_HUMAN TYR 2.6e-99 337.7 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 2QU5A P35968 816 1170 1356.0 276:501 Type2 Inactive DFGout 15.957 9.83 BBAminus -148.46, -172.65 -150.45, 108.8 -78.65, -16.42 280.25, 86.88 -99.11, -166.35 in-in in 7.874 Saltbr-in 2.752 HRD-in -80.82, -52.31 94.02, -25.74 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -87.63, 5.51 APE9-dihe-out 37.61, 55.41 APE8-dihe-out -52.54, -22.13 APE8-rot-na 25.49 APE67-dihe-in -67.04, -17.69 -59.89, -24.68 APE12-dist-na 10.279 APE11-dist-na 14.224 APE10-dist-na 11.11 APE9-dist-out 11.322 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.95 0.213 0.251 A 314 292 13 0 0 13 [[834, 1162]] 1.0 2qu5 Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 2QU6A P35968 817 1171 1356.0 857:60501 Type2 Inactive DFGout 15.942 9.817 BBAminus -132.31, -170.97 -155.67, 103.74 -71.24, -21.04 287.6, 86.95 -49.98, 999.0 in-in in 7.837 Saltbr-in 3.056 HRD-in -61.86, -49.75 81.1, -16.44 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 40.43 APE8-rot-na 31.68 APE67-dihe-in -68.37, -13.6 -54.82, -35.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.1 0.242 0.272 A 314 276 29 0 0 19 [[834, 1162]] 1.0 2qu6 Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 2RL5A P35968 815 1171 1356.0 2RL:60501 Type2 Inactive DFGout 15.392 11.07 BBAminus -145.48, -175.23 -148.97, 113.05 -80.1, -11.01 289.69, 95.02 69.28, 57.0 in-in in 7.826 Saltbr-in 2.698 HRD-in -65.08, -49.32 80.71, -16.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -86.71, -13.59 APE9-dihe-out 45.53, 52.75 APE8-dihe-out -54.88, -21.97 APE8-rot-na 32.05 APE67-dihe-in -73.02, -12.93 -62.39, -23.08 APE12-dist-na 7.93 APE11-dist-na 10.632 APE10-dist-na 6.743 APE9-dist-out 11.661 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.65 0.199 0.233 A 314 290 17 0 0 14 [[834, 1162]] 1.0 2rl5 Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3B8QB P35968 820 1166 1356.0 900:60502 Type2 Inactive DFGout 15.404 10.078 BBAminus -136.11, -171.43 -160.46, 118.31 -80.85, -45.83 290.91, 83.9 123.21, 999.0 in-in in 7.898 Saltbr-in 2.903 HRD-in -68.36, -46.63 75.78, -5.88 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 155.56 APE8-dihe-out -60.35, -14.62 APE8-rot-na 30.93 APE67-dihe-in -68.62, -6.92 -55.79, -32.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.297 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.75 0.218 0.276 B 314 271 26 0 0 18 [[834, 1162]] 1.0 3b8q Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3BE2A P35968 815 1171 1356.0 RAJ:60501 Type2 Inactive DFGout 14.113 11.043 BBAminus -134.72, 177.84 -152.38, 97.13 -77.52, -8.1 302.77, 127.65 76.19, 999.0 in-in in 7.941 Saltbr-in 2.769 HRD-in -67.93, -53.26 79.3, -9.77 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 56.48 APE8-rot-na 341.32 APE67-dihe-in -65.72, -14.43 -46.07, -42.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 1.75 0.197 0.226 A 314 285 22 0 0 19 [[834, 1162]] 1.0 3be2 Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3CP9A P35968 817 1171 1356.0 C19:60501 Type2 Inactive DFGout 16.62 10.275 BBAminus -128.38, -176.57 -155.05, 99.17 -63.66, -9.88 278.68, 88.56 -54.74, 999.0 in-in in 7.733 Saltbr-in 2.636 HRD-in -61.14, -53.92 79.09, -9.79 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 101.57 APE8-dihe-out -50.34, -15.58 APE8-rot-na 28.54 APE67-dihe-in -69.67, -13.51 -65.76, -26.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.578 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.5 0.211 0.263 A 314 281 24 0 0 18 [[834, 1162]] 1.0 3cp9 Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3CP9B P35968 819 1165 1356.0 C19:60502 Type2 Inactive DFGout 16.841 10.404 BBAminus -132.75, -171.12 -162.18, 105.04 -62.12, -28.88 281.99, 80.12 49.45, -86.0 in-in in 7.646 Saltbr-in 3.048 HRD-in -88.31, -43.32 78.52, -15.92 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -57.69 APE8-dihe-out -39.24, -27.85 APE8-rot-na 24.86 APE67-dihe-in -68.9, -8.27 -59.68, -31.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.44 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.5 0.211 0.263 B 314 269 28 0 0 17 [[834, 1162]] 1.0 3cp9 Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3CPCB P35968 820 1165 1356.0 C52:60002 Type2 Inactive DFGout 16.639 10.379 BBAminus -131.82, -178.95 -148.17, 107.11 -69.23, -53.88 273.75, 87.39 111.77, 999.0 in-in in 7.485 Saltbr-in 2.706 HRD-in -75.42, -46.4 80.7, -16.54 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -53.89 APE8-dihe-out -53.45, -16.48 APE8-rot-na 17.35 APE67-dihe-in -69.92, -17.21 -63.01, -26.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.384 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.4 0.221 0.272 B 314 262 34 0 0 18 [[834, 1162]] 1.0 3cpc Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3DTWB P35968 820 1166 1356.0 A96:60502 Type2 Inactive DFGout 15.036 10.168 BBAminus -136.42, -166.86 -159.08, 106.24 -84.37, -81.02 295.18, 95.96 174.82, 139.27 in-in in 8.177 Saltbr-in 2.957 HRD-in -66.59, -51.66 77.85, -16.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, 31.74 APE9-dihe-out -53.82, -56.19 APE8-dihe-out -45.11, -17.45 APE8-rot-na 28.36 APE67-dihe-in -71.35, -4.04 -72.8, -21.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.291 APE9-dist-out 11.527 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.9 0.215 0.279 B 314 269 28 0 0 16 [[834, 1162]] 1.0 3dtw Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3EWHA P35968 815 1171 1356.0 K11:60001 Type2 Inactive DFGout 15.139 11.42 BBAminus -133.49, -179.18 -135.71, 102.66 -69.48, -9.86 280.78, 102.57 67.93, 33.26 in-in in 7.937 Saltbr-in 3.079 HRD-in -71.49, -51.89 78.14, -10.7 in-out-none SNCion out-none ActLoopNT-out 12.944 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.93 APE8-dihe-in -76.46, 69.83 APE8-rot-na 30.0 APE67-dihe-in -66.36, -17.49 -56.88, -35.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.972 C817A,V916T,E990V None None XRAY 1.6 0.208 0.234 A 314 295 12 0 0 9 [[834, 1162]] 1.0 3ewh Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3U6JA P35968 815 1171 1356.0 03X:60001 Type2 Inactive DFGout 14.979 10.356 BBAminus -144.73, -178.41 -146.44, 121.96 -64.93, -27.75 282.37, 79.48 52.91, -122.32 in-in in 7.455 Saltbr-in 2.867 HRD-in -74.57, -56.02 80.88, -14.69 in-out-in SNCioi out-in ActLoopNT-out 16.133 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.27, 117.84 APE9-dihe-in -122.3, 141.03 APE8-dihe-in -77.42, 64.76 APE8-rot-na 30.56 APE67-dihe-in -69.06, -14.4 -51.48, -37.1 APE12-dist-na 17.368 APE11-dist-na 14.214 APE10-dist-na 12.387 APE9-dist-in 7.733 V916T,E990V None None XRAY 2.15 0.196 0.23 A 314 305 2 0 0 0 [[834, 1162]] 1.0 3u6j Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3C7QA P35968 819 1171 1356.0 XIN:1172 Type1 Inactive DFGout 15.785 9.794 None -118.96, 138.15 -110.64, 113.79 -73.47, 999.0 192.45, 128.99 999.0, 999.0 in-in in 7.283 Saltbr-in 2.608 HRD-in -83.9, -48.68 82.47, -6.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -147.17, 145.76 APE9-dihe-in -104.98, 98.81 APE8-dihe-out -50.37, -26.53 APE8-rot-na 330.15 APE67-dihe-in -62.19, -10.0 -56.65, -35.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.175 None PTR1054,PTR1059 CME862,CME1007,CME1024,PTR1054,PTR1059 XRAY 2.1 0.221 0.279 A 316 291 10 0 0 4 [[834, 1162]] 1.0 3c7q Homo sapiens TYR_KDR_HUMAN TYR 3.9e-100 340.4 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 2P2IB P35968 820 1168 1356.0 608:60502 Type1 Inactive DFGout 16.274 10.204 None -141.39, -171.24 -157.47, 119.0 -85.08, 999.0 285.18, 81.66 999.0, 999.0 in-in in 7.143 Saltbr-in 3.271 HRD-in -71.95, -45.89 71.89, -7.38 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 36.68 APE8-rot-na 31.31 APE67-dihe-in -54.41, -18.08 -58.67, -41.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C817A,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.4 0.222 0.266 B 314 263 36 0 0 20 [[834, 1162]] 1.0 2p2i Homo sapiens TYR_KDR_HUMAN TYR 4e-100 340.4 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3VNTA P35968 812 1168 1356.0 0JA:2001 Type2 Inactive DFGout 16.764 8.386 None -132.49, -178.83 -142.53, 104.52 -68.92, -32.97 219.02, 49.93 58.07, -122.23 in-in in 7.468 Saltbr-in 2.746 HRD-in -79.08, -51.8 75.79, -7.69 in-out-in SNCioi out-in ActLoopNT-out 16.542 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.01, 111.64 APE9-dihe-in -121.89, 148.7 APE8-dihe-in -79.2, 68.13 APE8-rot-na 30.95 APE67-dihe-in -64.82, -12.79 -56.01, -39.41 APE12-dist-na 16.826 APE11-dist-na 13.454 APE10-dist-na 11.292 APE9-dist-in 7.869 None None None XRAY 1.64 0.153 0.192 A 318 301 6 0 0 0 [[834, 1162]] 1.0 3vnt Homo sapiens TYR_KDR_HUMAN TYR 4.2e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3VO3A P35968 812 1168 1356.0 0KF:2001 Type2 Inactive DFGout 16.448 8.215 None -125.16, 179.81 -141.05, 99.79 -70.03, -34.74 215.55, 55.41 59.77, -120.61 in-in in 7.357 Saltbr-in 2.898 HRD-in -84.45, -53.71 76.95, -3.4 in-out-in SNCioi out-in ActLoopNT-out 16.477 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.91, 109.54 APE9-dihe-in -120.7, 147.5 APE8-dihe-in -78.09, 65.8 APE8-rot-na 32.33 APE67-dihe-in -67.73, -12.3 -53.4, -39.21 APE12-dist-na 17.03 APE11-dist-na 14.067 APE10-dist-na 11.393 APE9-dist-in 7.997 None None None XRAY 1.52 0.162 0.182 A 318 303 4 0 0 0 [[834, 1162]] 1.0 3vo3 Homo sapiens TYR_KDR_HUMAN TYR 4.2e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 2QU6B P35968 822 1165 1356.0 857:60502 Type2 Inactive DFGout 15.963 9.541 None -133.96, -169.17 -160.0, 100.56 -72.82, 999.0 288.62, 90.71 999.0, 999.0 in-in in 7.953 Saltbr-in 3.095 HRD-in -62.66, -51.11 76.69, -2.42 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.74 APE8-dihe-in -72.44, 73.71 APE8-rot-na 32.18 APE67-dihe-in -66.59, -17.43 -56.47, -30.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.292 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.1 0.242 0.272 B 314 260 34 0 0 19 [[834, 1162]] 1.0 2qu6 Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3B8QA P35968 818 1171 1356.0 900:60501 Type2 Inactive DFGout 15.467 9.913 None -131.74, -168.2 -159.75, 118.5 -86.72, 999.0 284.22, 100.5 999.0, 999.0 in-in in 7.759 Saltbr-in 2.765 HRD-in -57.53, -50.67 79.88, -14.29 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 160.03 APE8-dihe-out -77.48, -12.97 APE8-rot-na 36.4 APE67-dihe-in -68.93, -8.62 -57.21, -28.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.072 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.75 0.218 0.276 A 314 285 19 0 0 19 [[834, 1162]] 1.0 3b8q Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3CPBA P35968 819 1171 1356.0 C92:60001 Type2 Inactive DFGout 15.333 9.751 None -143.96, -172.89 -147.19, 119.38 -89.94, 999.0 278.49, 101.53 999.0, 999.0 in-in in 7.763 Saltbr-in 3.585 HRD-in -60.85, -44.16 62.59, 3.77 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.93 APE8-dihe-out -45.12, -28.83 APE8-rot-na 328.95 APE67-dihe-in -65.36, -7.17 -53.29, -33.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.351 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.7 0.224 0.286 A 314 278 25 0 0 19 [[834, 1162]] 1.0 3cpb Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3CPCA P35968 820 1171 1356.0 C52:60001 Type2 Inactive DFGout 16.803 10.382 None -127.27, -176.88 -144.84, 92.18 -66.45, 999.0 268.44, 99.63 999.0, 999.0 in-out in 8.027 Saltbr-out 3.977 HRD-in -74.56, -44.56 79.03, -21.68 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.84 APE8-dihe-out -45.97, -30.08 APE8-rot-na 328.28 APE67-dihe-in -73.13, -9.14 -56.02, -29.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.356 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.4 0.221 0.272 A 314 277 25 0 0 19 [[834, 1162]] 1.0 3cpc Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3DTWA P35968 818 1171 1356.0 A96:60501 Type2 Inactive DFGout 15.158 10.099 None -129.54, -170.94 -153.49, 103.32 -82.68, 999.0 294.21, 96.03 999.0, 999.0 in-in in 8.006 Saltbr-in 2.64 HRD-in -53.04, -53.77 79.82, -12.25 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.1 APE8-dihe-out -46.34, -20.16 APE8-rot-na 23.94 APE67-dihe-in -60.71, -7.92 -57.08, -38.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.234 C817A,V916T,E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 2.9 0.215 0.279 A 314 281 23 0 0 19 [[834, 1162]] 1.0 3dtw Homo sapiens TYR_KDR_HUMAN TYR 2.8e-100 340.9 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3CJFA P35968 817 1168 1356.0 SAV:61167 Type1 Inactive None 999.0 999.0 None -83.44, 111.78 -118.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 7.821 Saltbr-out 5.223 HRD-out -105.6, 121.11 -71.37, -10.71 out-in-none SNCoin in-none ActLoopNT-in 2.889 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 48.59 APE8-rot-na 25.36 APE67-dihe-in -69.88, -14.36 -60.34, -37.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None CSO862,CSO1007,CSO1024,CSO1045,CSO1116 XRAY 2.15 0.205 0.258 A 309 281 17 0 0 14 [[834, 1162]] 1.0 3cjf Homo sapiens TYR_KDR_HUMAN TYR 4.8e-100 340.1 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 1YWNA P35968 820 1171 1356.0 LIF:60301 Type1 Inactive None 999.0 999.0 None -128.91, 171.96 -143.62, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.21 Saltbr-in 2.725 HRD-in -77.88, -50.07 82.87, -17.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -141.39, 161.44 APE9-dihe-in -104.18, 100.32 APE8-dihe-out -56.09, -24.71 APE8-rot-na 336.02 APE67-dihe-in -70.59, -14.0 -51.58, -32.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.239 E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 1.71 0.206 0.23 A 316 281 21 0 0 6 [[834, 1162]] 1.0 1ywn Homo sapiens TYR_KDR_HUMAN TYR 4.1e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
VGFR2_HUMAN 3VIDA P35968 813 1168 1356.0 4TT:2001 Type1 Inactive None 999.0 999.0 None -128.64, 167.68 -132.79, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.326 Saltbr-in 2.98 HRD-in -77.53, -50.55 79.3, -13.28 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -152.12, 159.09 APE9-dihe-in -96.12, 109.5 APE8-dihe-out -66.36, -14.96 APE8-rot-na 337.32 APE67-dihe-in -69.61, -3.71 -60.46, -30.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.378 None None None XRAY 2.3 0.247 0.281 A 356 299 57 0 0 7 [[834, 1162]] 1.0 3vid Homo sapiens TYR_KDR_HUMAN TYR 2.3e-99 337.8 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2

TYR_KDR (Vascular endothelial growth factor receptor 2)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name