CMGC_CLK1 (Dual specificity protein kinase CLK1)

Total number of chains: 61
Active chains: 39
Family: CMGC
Uniprot: CLK1_HUMAN
Kinase Domain Residues: 161 - 477
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 59 96.7% AF-P49759-K3A
DFGin ABAminus 1 1.6% 6KHDC
DFGin None 1 1.6% 6KHDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P49759-K3A 153 484 484.0 No_ligand No_ligand Active DFGin 6.943 14.15 BLAminus -132.48, 177.39 60.27, 71.57 -85.18, 10.53 300.3, 105.86 -66.37, -11.95 in-in in 8.442 Saltbr-in 2.717 HRD-in -74.62, -35.37 68.27, -12.7 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.72, 174.26 APE9-dihe-na 63.43, 136.97 APE8-dihe-in -54.83, 138.19 APE8-rot-in 291.39 APE67-dihe-in -67.82, -20.27 -52.33, -42.8 APE12-dist-in 13.892 APE11-dist-in 11.523 APE10-dist-in 7.732 APE9-dist-in 3.006 None None None AF2 -1.0 1.0 1.0 A 332 332 0 0 0 0 [[161, 477]] 1.0 AF-P49759-K3 CMGC_CLK1_HUMAN CMGC 1.8e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6YTDA 148 484 484.0 EAE:60501 Type1 Active DFGin 7.218 14.624 BLAminus -129.04, -179.37 68.43, 75.26 -99.43, 5.66 289.75, 100.38 -57.22, -23.43 in-in in 8.789 Saltbr-in 2.743 HRD-in -67.84, -52.77 79.42, -15.7 in-in-in SNCiii in-in ActLoopNT-in 2.956 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.91, 160.56 APE9-dihe-na 78.51, 152.43 APE8-dihe-in -82.58, 136.21 APE8-rot-in 297.75 APE67-dihe-in -72.13, -8.69 -31.46, -59.55 APE12-dist-in 13.409 APE11-dist-in 11.117 APE10-dist-in 7.411 APE9-dist-in 2.986 V324A None None XRAY 2.0 0.182 0.228 A 339 337 0 0 0 0 [[161, 477]] 1.0 6ytd CMGC_CLK1_HUMAN CMGC 1.5e-93 319.2 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6QTYA 149 481 484.0 V25:501 Type1 Active DFGin 7.189 13.828 BLAminus -129.69, 172.83 71.11, 83.55 -99.13, 16.45 297.38, 96.6 -71.94, -15.11 in-in in 8.324 Saltbr-in 2.651 HRD-in -69.24, -51.3 77.68, -14.79 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.16, 166.1 APE9-dihe-na 76.64, 158.21 APE8-dihe-in -87.0, 137.14 APE8-rot-in 293.42 APE67-dihe-in -62.6, -10.5 -44.79, -53.3 APE12-dist-in 12.981 APE11-dist-in 11.463 APE10-dist-in 7.478 APE9-dist-in 3.088 None None None XRAY 1.65 0.139 0.203 A 337 333 0 0 0 0 [[161, 477]] 1.0 6qty CMGC_CLK1_HUMAN CMGC 1.9e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6R3DA 152 481 484.0 JQW:901 Type1 Active DFGin 7.236 14.013 BLAminus -122.46, 176.35 64.69, 84.91 -101.75, 18.8 296.55, 100.55 -62.91, -23.24 in-in in 8.272 Saltbr-in 2.938 HRD-in -66.66, -51.76 77.65, -11.03 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.87, 173.33 APE9-dihe-na 73.0, 159.5 APE8-dihe-in -89.36, 141.36 APE8-rot-in 302.1 APE67-dihe-in -68.09, -12.73 -48.4, -46.85 APE12-dist-in 13.178 APE11-dist-in 11.688 APE10-dist-in 7.569 APE9-dist-in 2.994 None None None XRAY 1.85 0.223 0.265 A 337 330 0 0 0 0 [[161, 477]] 1.0 6r3d CMGC_CLK1_HUMAN CMGC 1.9e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6R6EA 153 481 484.0 JTQ:901 Type1 Active DFGin 7.288 14.296 BLAminus -128.0, 174.1 72.24, 79.12 -104.06, 19.03 290.47, 84.52 -68.66, -15.84 in-in in 8.409 Saltbr-in 2.745 HRD-in -60.82, -42.83 67.21, -15.33 in-in-in SNCiii in-in ActLoopNT-in 2.75 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.15, 166.85 APE9-dihe-na 79.69, 155.93 APE8-dihe-in -74.39, 146.66 APE8-rot-in 301.47 APE67-dihe-in -66.87, -19.64 -52.56, -47.56 APE12-dist-in 13.177 APE11-dist-in 11.708 APE10-dist-in 7.616 APE9-dist-in 3.091 None None None XRAY 2.25 0.209 0.258 A 337 327 2 0 0 0 [[161, 477]] 1.0 6r6e CMGC_CLK1_HUMAN CMGC 1.9e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6R6XA 152 481 484.0 JU8:901 Type1 Active DFGin 7.191 13.882 BLAminus -123.65, 175.5 67.74, 78.23 -100.49, 14.01 300.01, 96.17 -58.94, -19.36 in-in in 8.437 Saltbr-in 2.746 HRD-in -67.05, -47.28 77.18, -15.83 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.71, 173.64 APE9-dihe-na 76.22, 157.17 APE8-dihe-in -81.77, 144.6 APE8-rot-in 304.54 APE67-dihe-in -66.2, -13.27 -49.16, -50.71 APE12-dist-in 12.988 APE11-dist-in 11.623 APE10-dist-in 7.49 APE9-dist-in 3.042 None None None XRAY 2.05 0.201 0.247 A 337 330 0 0 0 0 [[161, 477]] 1.0 6r6x CMGC_CLK1_HUMAN CMGC 1.9e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
7O9YA 152 481 484.0 V5T:501 Type1 Active DFGin 7.246 13.687 BLAminus -122.5, 174.1 68.65, 82.2 -100.77, 14.37 301.76, 93.94 -56.91, -24.51 in-in in 8.153 Saltbr-in 2.762 HRD-in -69.77, -51.58 81.58, -12.75 in-in-in SNCiii in-in ActLoopNT-in 2.851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.84, 169.0 APE9-dihe-na 74.97, 161.24 APE8-dihe-in -86.97, 141.45 APE8-rot-in 302.46 APE67-dihe-in -63.2, -13.37 -47.79, -52.2 APE12-dist-in 12.972 APE11-dist-in 11.507 APE10-dist-in 7.486 APE9-dist-in 3.08 None None None XRAY 1.66 0.219 0.246 A 337 330 0 0 0 0 [[161, 477]] 1.0 7o9y CMGC_CLK1_HUMAN CMGC 1.9e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
7OA0AAA 152 481 484.0 JTQ:501 Type1 Active DFGin 7.208 13.869 BLAminus -123.62, 171.83 70.68, 87.81 -105.24, 18.66 295.8, 102.89 -75.22, -10.65 in-in in 8.248 Saltbr-in 2.75 HRD-in -68.11, -52.1 81.61, -13.16 in-in-in SNCiii in-in ActLoopNT-in 2.859 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.31, 171.34 APE9-dihe-na 77.29, 158.23 APE8-dihe-in -81.59, 143.88 APE8-rot-in 304.32 APE67-dihe-in -62.82, -8.69 -51.01, -53.79 APE12-dist-in 13.049 APE11-dist-in 11.57 APE10-dist-in 7.474 APE9-dist-in 3.03 None None None XRAY 1.81 0.195 0.242 AAA 337 330 0 0 0 0 [[161, 477]] 1.0 7oa0 CMGC_CLK1_HUMAN CMGC 1.9e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
1Z57A 148 482 484.0 DBQ:60001 Type1 Active DFGin 6.981 14.002 BLAminus -125.78, 172.53 74.79, 89.46 -108.53, 21.5 296.6, 99.61 -72.51, -21.17 in-in in 8.466 Saltbr-in 2.788 HRD-in -70.25, -52.83 80.14, -14.55 in-in-in SNCiii in-in ActLoopNT-in 2.943 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.0, 169.19 APE9-dihe-na 76.16, 157.77 APE8-dihe-in -82.83, 140.18 APE8-rot-in 294.7 APE67-dihe-in -63.99, -15.88 -47.28, -50.61 APE12-dist-in 13.322 APE11-dist-in 11.223 APE10-dist-in 7.313 APE9-dist-in 3.001 None None None XRAY 1.7 0.14 0.186 A 339 331 4 0 0 0 [[161, 477]] 1.0 1z57 CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
5J1VA 148 483 484.0 6FD:60501 Type1 Active DFGin 7.1 14.172 BLAminus -126.87, 172.93 72.75, 87.91 -109.91, 21.95 296.61, 87.13 -77.69, -9.89 in-in in 8.527 Saltbr-in 2.736 HRD-in -74.36, -52.4 82.96, -16.81 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.9, 168.51 APE9-dihe-na 72.23, 149.39 APE8-dihe-in -71.93, 136.52 APE8-rot-in 285.15 APE67-dihe-in -66.67, -20.56 -35.82, -53.71 APE12-dist-in 13.528 APE11-dist-in 11.444 APE10-dist-in 7.281 APE9-dist-in 3.043 None None None XRAY 2.52 0.201 0.244 A 339 336 0 0 0 0 [[161, 477]] 1.0 5j1v CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
5J1VB 148 482 484.0 6FD:60501 Type1 Active DFGin 7.109 14.12 BLAminus -126.74, 175.0 70.24, 87.64 -108.44, 20.05 295.73, 90.04 -77.7, -8.55 in-in in 8.576 Saltbr-in 2.754 HRD-in -73.08, -51.15 80.15, -14.17 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.41, 168.72 APE9-dihe-na 72.72, 151.05 APE8-dihe-in -70.92, 135.35 APE8-rot-in 286.36 APE67-dihe-in -65.82, -21.41 -37.05, -51.94 APE12-dist-in 13.782 APE11-dist-in 11.542 APE10-dist-in 7.356 APE9-dist-in 3.05 None None None XRAY 2.52 0.201 0.244 B 339 335 0 0 0 0 [[161, 477]] 1.0 5j1v CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
5J1WA 148 483 484.0 6FB:60506 Type1 Active DFGin 7.172 14.326 BLAminus -121.81, 173.7 71.87, 86.58 -105.02, 20.94 296.61, 84.3 -77.49, -14.22 in-in in 8.549 Saltbr-in 2.564 HRD-in -71.53, -50.92 81.49, -14.91 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.47, 167.51 APE9-dihe-na 77.02, 140.17 APE8-dihe-in -56.28, 137.97 APE8-rot-in 295.84 APE67-dihe-in -62.06, -22.4 -61.94, -35.28 APE12-dist-in 13.605 APE11-dist-in 11.437 APE10-dist-in 7.252 APE9-dist-in 3.042 None None None XRAY 2.42 0.191 0.228 A 339 336 0 0 0 0 [[161, 477]] 1.0 5j1w CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
5J1WB 148 482 484.0 6FB:60503 Type1 Active DFGin 7.29 14.265 BLAminus -120.99, 173.46 72.42, 86.12 -105.34, 21.92 296.07, 87.01 -75.02, -15.34 in-in in 8.585 Saltbr-in 2.585 HRD-in -69.32, -50.91 80.3, -14.73 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.41, 167.18 APE9-dihe-na 77.9, 139.82 APE8-dihe-in -54.28, 138.17 APE8-rot-in 296.7 APE67-dihe-in -62.44, -21.37 -62.69, -34.82 APE12-dist-in 13.648 APE11-dist-in 11.342 APE10-dist-in 7.196 APE9-dist-in 3.035 None None None XRAY 2.42 0.191 0.228 B 339 335 0 0 0 0 [[161, 477]] 1.0 5j1w CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6FT8A 148 483 484.0 E6T:60501 Type1 Active DFGin 7.042 14.153 BLAminus -123.69, 179.12 66.02, 80.75 -102.66, 23.58 296.94, 92.84 -75.28, -12.2 in-in in 8.448 Saltbr-in 2.743 HRD-in -68.91, -53.98 78.36, -16.69 in-in-in SNCiii in-in ActLoopNT-in 2.941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.28, 167.17 APE9-dihe-na 78.21, 159.73 APE8-dihe-in -85.1, 140.33 APE8-rot-in 293.05 APE67-dihe-in -66.99, -12.12 -49.73, -45.92 APE12-dist-in 13.282 APE11-dist-in 11.517 APE10-dist-in 7.327 APE9-dist-in 3.029 None None None XRAY 1.45 0.166 0.195 A 339 336 0 0 0 0 [[161, 477]] 1.0 6ft8 CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6FT9A 148 482 484.0 E6W:60501 Type1 Active DFGin 7.232 14.3 BLAminus -125.02, 175.42 67.64, 86.22 -106.42, 22.86 292.22, 81.03 -75.21, -13.41 in-in in 8.43 Saltbr-in 2.712 HRD-in -69.31, -51.72 79.55, -13.59 in-in-in SNCiii in-in ActLoopNT-in 2.866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.87, 168.01 APE9-dihe-na 73.7, 150.41 APE8-dihe-in -70.08, 140.16 APE8-rot-in 296.52 APE67-dihe-in -66.14, -21.84 -44.66, -47.8 APE12-dist-in 13.556 APE11-dist-in 11.218 APE10-dist-in 7.279 APE9-dist-in 2.933 None None None XRAY 1.87 0.168 0.202 A 339 335 0 0 0 0 [[161, 477]] 1.0 6ft9 CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6FT9B 148 482 484.0 E6W:60501 Type1 Active DFGin 7.294 14.314 BLAminus -123.52, 178.1 65.34, 85.29 -106.33, 21.22 292.88, 84.42 -75.16, -8.95 in-in in 8.486 Saltbr-in 2.708 HRD-in -71.01, -50.08 80.37, -13.57 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.43, 168.15 APE9-dihe-na 75.76, 149.1 APE8-dihe-in -68.06, 138.01 APE8-rot-in 296.86 APE67-dihe-in -65.44, -22.15 -43.68, -46.72 APE12-dist-in 13.745 APE11-dist-in 11.277 APE10-dist-in 7.284 APE9-dist-in 2.966 None None None XRAY 1.87 0.168 0.202 B 339 335 0 0 0 0 [[161, 477]] 1.0 6ft9 CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6I5HA 148 481 484.0 H3N:60507 Type1 Active DFGin 6.936 13.99 BLAminus -127.91, 175.49 70.62, 86.84 -104.99, 23.28 297.7, 98.27 -76.67, -15.26 in-in in 8.671 Saltbr-in 2.794 HRD-in -71.42, -54.52 81.98, -15.98 in-in-in SNCiii in-in ActLoopNT-in 2.989 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.5, 162.59 APE9-dihe-na 81.01, 150.81 APE8-dihe-in -73.05, 137.12 APE8-rot-in 298.85 APE67-dihe-in -65.31, -13.64 -50.7, -47.04 APE12-dist-in 12.982 APE11-dist-in 11.325 APE10-dist-in 7.234 APE9-dist-in 3.097 None None None XRAY 1.49 0.179 0.206 A 339 323 11 0 0 0 [[161, 477]] 1.0 6i5h CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6I5IA 148 483 484.0 H3E:60501 Type1 Active DFGin 6.909 13.949 BLAminus -127.6, 172.7 71.85, 87.8 -102.42, 20.37 300.05, 101.13 -74.42, -16.22 in-in in 8.713 Saltbr-in 2.693 HRD-in -75.53, -52.34 81.22, -14.82 in-in-in SNCiii in-in ActLoopNT-in 2.998 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.19, 164.34 APE9-dihe-na 79.5, 152.78 APE8-dihe-in -78.57, 135.82 APE8-rot-in 292.41 APE67-dihe-in -65.9, -11.23 -46.6, -47.35 APE12-dist-in 13.114 APE11-dist-in 11.284 APE10-dist-in 7.252 APE9-dist-in 3.074 None None None XRAY 1.6 0.166 0.196 A 339 333 3 0 0 0 [[161, 477]] 1.0 6i5i CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6I5KB 148 481 484.0 H3H:60504 Type1 Active DFGin 7.006 14.359 BLAminus -126.82, 178.06 66.53, 84.63 -104.0, 26.37 299.27, 91.89 -80.46, -16.31 in-in in 9.029 Saltbr-in 2.693 HRD-in -71.59, -48.77 75.18, -11.75 in-in-in SNCiii in-in ActLoopNT-in 2.984 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.96, 164.13 APE9-dihe-na 74.43, 150.15 APE8-dihe-in -66.68, 137.66 APE8-rot-in 303.78 APE67-dihe-in -77.74, -18.3 -54.0, -31.51 APE12-dist-in 13.844 APE11-dist-in 11.224 APE10-dist-in 7.395 APE9-dist-in 3.093 None None None XRAY 2.3 0.197 0.224 B 339 334 0 0 0 0 [[161, 477]] 1.0 6i5k CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6I5KC 148 483 484.0 H3H:60504 Type1 Active DFGin 6.987 14.351 BLAminus -125.41, 178.1 66.91, 85.45 -105.62, 25.72 298.18, 84.65 -79.89, -19.48 in-in in 8.919 Saltbr-in 2.666 HRD-in -72.35, -49.89 76.53, -11.56 in-in-in SNCiii in-in ActLoopNT-in 3.001 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.9, 163.92 APE9-dihe-na 72.8, 149.97 APE8-dihe-in -66.75, 139.4 APE8-rot-in 303.5 APE67-dihe-in -77.85, -17.5 -52.64, -34.11 APE12-dist-in 13.616 APE11-dist-in 11.124 APE10-dist-in 7.341 APE9-dist-in 3.112 None None None XRAY 2.3 0.197 0.224 C 339 336 0 0 0 0 [[161, 477]] 1.0 6i5k CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6I5LB 148 481 484.0 H3Q:60502 Type1 Active DFGin 6.928 14.418 BLAminus -123.55, 178.93 67.48, 93.05 -113.53, 21.71 295.78, 85.8 -74.38, -22.09 in-in in 8.982 Saltbr-in 2.74 HRD-in -69.85, -49.79 74.87, -13.88 in-in-in SNCiii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.82, 165.73 APE9-dihe-na 81.08, 146.54 APE8-dihe-in -62.76, 135.54 APE8-rot-in 302.63 APE67-dihe-in -68.98, -24.89 -54.53, -33.68 APE12-dist-in 13.852 APE11-dist-in 11.417 APE10-dist-in 7.226 APE9-dist-in 3.102 None None None XRAY 2.55 0.195 0.221 B 339 334 0 0 0 0 [[161, 477]] 1.0 6i5l CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6I5LC 148 483 484.0 H3Q:60502 Type1 Active DFGin 6.913 14.384 BLAminus -123.57, 177.17 68.91, 92.22 -114.6, 21.5 296.12, 85.91 -74.75, -23.49 in-in in 8.878 Saltbr-in 2.711 HRD-in -71.08, -49.61 75.52, -13.95 in-in-in SNCiii in-in ActLoopNT-in 3.021 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.58, 165.38 APE9-dihe-na 80.23, 146.0 APE8-dihe-in -62.57, 137.3 APE8-rot-in 302.62 APE67-dihe-in -70.1, -23.69 -53.95, -35.33 APE12-dist-in 13.658 APE11-dist-in 11.337 APE10-dist-in 7.179 APE9-dist-in 3.136 None None None XRAY 2.55 0.195 0.221 C 339 336 0 0 0 0 [[161, 477]] 1.0 6i5l CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6Q8KA 148 484 484.0 FG9:60502 Type1 Active DFGin 7.038 14.073 BLAminus -126.96, 173.92 68.96, 94.14 -110.91, 19.67 299.22, 86.31 -70.74, -15.36 in-in in 8.789 Saltbr-in 2.697 HRD-in -64.71, -54.26 80.91, -18.18 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.28, 157.45 APE9-dihe-na 83.98, 154.49 APE8-dihe-in -77.73, 126.84 APE8-rot-in 298.77 APE67-dihe-in -63.27, -22.97 -33.76, -49.02 APE12-dist-in 13.367 APE11-dist-in 11.286 APE10-dist-in 7.468 APE9-dist-in 3.111 None None None XRAY 2.29 0.191 0.259 A 339 337 0 0 0 0 [[161, 477]] 1.0 6q8k CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6YTAA 148 483 484.0 IYZ:60702 Type1 Active DFGin 6.935 13.725 BLAminus -125.39, 175.02 66.16, 92.34 -102.15, 17.18 301.41, 98.15 -60.08, -20.3 in-in in 8.317 Saltbr-in 2.699 HRD-in -68.08, -57.05 83.09, -18.57 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.65, 155.94 APE9-dihe-na 83.67, 157.83 APE8-dihe-in -84.55, 129.06 APE8-rot-in 292.9 APE67-dihe-in -62.02, -24.22 -28.74, -53.35 APE12-dist-in 13.211 APE11-dist-in 11.663 APE10-dist-in 7.375 APE9-dist-in 3.159 None None None XRAY 2.3 0.194 0.275 A 339 336 0 0 0 0 [[161, 477]] 1.0 6yta CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6YTEC 148 484 484.0 EAE:60501 Type1 Active DFGin 7.145 14.111 BLAminus -123.36, 172.5 72.26, 86.11 -107.09, 11.71 295.65, 98.47 -58.29, -17.8 in-in in 8.544 Saltbr-in 2.225 HRD-in -60.42, -59.86 88.88, -8.99 in-in-in SNCiii in-in ActLoopNT-in 3.005 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.24, 160.76 APE9-dihe-na 81.35, 157.72 APE8-dihe-in -87.96, 130.83 APE8-rot-in 293.05 APE67-dihe-in -54.77, -23.25 -31.22, -65.53 APE12-dist-in 13.375 APE11-dist-in 11.44 APE10-dist-in 7.321 APE9-dist-in 3.082 None None None XRAY 2.3 0.184 0.258 C 339 337 0 0 0 0 [[161, 477]] 1.0 6yte CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6YTIA 150 482 484.0 7A7:605 Type1 Active DFGin 7.292 14.242 BLAminus -134.7, 172.33 69.03, 94.12 -110.31, 22.0 290.95, 98.93 -72.82, -22.05 in-in in 8.645 Saltbr-in 2.617 HRD-in -68.46, -54.35 84.41, -17.31 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.78, 154.97 APE9-dihe-na 84.02, 157.2 APE8-dihe-in -78.01, 116.07 APE8-rot-in 301.91 APE67-dihe-in -65.16, -18.0 -14.75, -58.2 APE12-dist-in 13.417 APE11-dist-in 11.037 APE10-dist-in 7.456 APE9-dist-in 3.02 None None None XRAY 2.4 0.198 0.256 A 339 329 4 0 0 0 [[161, 477]] 1.0 6yti CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6Z4ZA 148 482 484.0 PQ5:60505 Type1 Active DFGin 7.046 14.236 BLAminus -126.68, 179.24 66.69, 82.0 -103.33, 19.73 297.68, 94.61 -71.59, -13.97 in-in in 8.461 Saltbr-in 2.764 HRD-in -69.38, -51.98 76.89, -13.79 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.91, 169.84 APE9-dihe-na 70.81, 154.45 APE8-dihe-in -79.18, 136.44 APE8-rot-in 295.15 APE67-dihe-in -64.16, -17.67 -45.6, -49.57 APE12-dist-in 13.513 APE11-dist-in 11.359 APE10-dist-in 7.327 APE9-dist-in 3.041 None None None XRAY 2.07 0.177 0.213 A 339 335 0 0 0 0 [[161, 477]] 1.0 6z4z CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6Z4ZB 148 484 484.0 PQ5:60501 Type1 Active DFGin 7.048 14.168 BLAminus -127.78, 179.44 66.36, 84.49 -106.02, 23.22 298.83, 96.06 -73.86, -11.97 in-in in 8.421 Saltbr-in 2.725 HRD-in -70.61, -51.12 77.5, -15.65 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.17, 168.57 APE9-dihe-na 73.19, 152.9 APE8-dihe-in -77.75, 136.06 APE8-rot-in 294.47 APE67-dihe-in -61.42, -18.21 -47.63, -47.77 APE12-dist-in 13.485 APE11-dist-in 11.247 APE10-dist-in 7.219 APE9-dist-in 3.052 None None None XRAY 2.07 0.177 0.213 B 339 337 0 0 0 0 [[161, 477]] 1.0 6z4z CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6Z4ZC 148 482 484.0 PQ5:60502 Type1 Active DFGin 7.108 14.249 BLAminus -126.87, 178.82 67.48, 81.17 -101.74, 18.48 298.94, 95.28 -65.75, -17.47 in-in in 8.567 Saltbr-in 2.763 HRD-in -67.93, -52.14 78.08, -12.45 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.01, 169.28 APE9-dihe-na 73.05, 151.25 APE8-dihe-in -74.69, 135.04 APE8-rot-in 294.69 APE67-dihe-in -63.57, -18.13 -46.66, -45.93 APE12-dist-in 13.708 APE11-dist-in 11.458 APE10-dist-in 7.407 APE9-dist-in 3.028 None None None XRAY 2.07 0.177 0.213 C 339 335 0 0 0 0 [[161, 477]] 1.0 6z4z CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6ZLNA 148 484 484.0 PKB:60503 Type1 Active DFGin 7.006 14.192 BLAminus -125.63, 176.89 76.78, 75.35 -103.44, 16.76 293.35, 98.15 -70.81, -12.33 in-in in 8.663 Saltbr-in 2.707 HRD-in -67.73, -49.47 78.97, -14.05 in-in-in SNCiii in-in ActLoopNT-in 2.935 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.54, 162.21 APE9-dihe-na 79.84, 163.79 APE8-dihe-in -96.39, 123.92 APE8-rot-in 291.96 APE67-dihe-in -72.31, -12.72 -20.91, -56.58 APE12-dist-in 13.233 APE11-dist-in 10.924 APE10-dist-in 7.217 APE9-dist-in 3.092 None None None XRAY 1.7 0.171 0.199 A 339 337 0 0 0 0 [[161, 477]] 1.0 6zln CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
7AK3A 148 483 484.0 RH8:60501 Type1 Active DFGin 7.32 14.284 BLAminus -128.56, 172.37 67.01, 84.33 -103.74, 27.34 296.18, 85.72 -72.52, -23.23 in-in in 8.603 Saltbr-in 2.865 HRD-in -61.61, -53.86 89.68, -14.81 in-in-in SNCiii in-in ActLoopNT-in 2.958 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.68, 162.47 APE9-dihe-na 75.05, 158.38 APE8-dihe-in -88.77, 128.79 APE8-rot-in 301.95 APE67-dihe-in -60.58, -28.09 -3.93, -77.31 APE12-dist-in 13.387 APE11-dist-in 11.15 APE10-dist-in 7.274 APE9-dist-in 2.998 None None None XRAY 2.5 0.213 0.26 A 339 336 0 0 0 0 [[161, 477]] 1.0 7ak3 CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
7OPGA 148 482 484.0 06N:60501 Type1 Active DFGin 7.079 14.337 BLAminus -125.23, 174.99 68.34, 89.35 -108.55, 22.34 294.5, 84.43 -74.9, -16.57 in-in in 8.828 Saltbr-in 2.697 HRD-in -68.7, -53.19 79.41, -13.79 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.87, 169.9 APE9-dihe-na 72.2, 152.58 APE8-dihe-in -74.2, 140.4 APE8-rot-in 296.34 APE67-dihe-in -64.01, -18.08 -47.78, -49.23 APE12-dist-in 13.454 APE11-dist-in 11.205 APE10-dist-in 7.289 APE9-dist-in 3.014 None None None XRAY 1.93 0.176 0.208 A 339 335 0 0 0 0 [[161, 477]] 1.0 7opg CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
7OPGB 148 483 484.0 06N:60501 Type1 Active DFGin 7.092 14.295 BLAminus -128.58, 171.98 71.57, 88.89 -110.25, 21.49 294.73, 85.57 -73.38, -14.32 in-in in 8.793 Saltbr-in 2.685 HRD-in -66.06, -53.32 81.87, -15.7 in-in-in SNCiii in-in ActLoopNT-in 2.843 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.09, 167.09 APE9-dihe-na 74.85, 150.04 APE8-dihe-in -76.84, 138.69 APE8-rot-in 295.58 APE67-dihe-in -61.09, -19.4 -51.05, -46.51 APE12-dist-in 13.276 APE11-dist-in 11.151 APE10-dist-in 7.227 APE9-dist-in 3.05 None None None XRAY 1.93 0.176 0.208 B 339 336 0 0 0 0 [[161, 477]] 1.0 7opg CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
7OPGC 148 482 484.0 06N:60501 Type1 Active DFGin 7.14 14.318 BLAminus -126.92, 172.88 71.54, 91.0 -109.11, 17.42 294.29, 87.52 -72.35, -14.96 in-in in 8.898 Saltbr-in 2.703 HRD-in -68.36, -53.23 82.74, -14.25 in-in-in SNCiii in-in ActLoopNT-in 2.837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.58, 169.34 APE9-dihe-na 74.62, 150.8 APE8-dihe-in -72.07, 139.48 APE8-rot-in 296.41 APE67-dihe-in -63.14, -17.95 -50.02, -46.94 APE12-dist-in 13.459 APE11-dist-in 11.323 APE10-dist-in 7.383 APE9-dist-in 3.025 None None None XRAY 1.93 0.176 0.208 C 339 335 0 0 0 0 [[161, 477]] 1.0 7opg CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6FYOA 148 481 484.0 EAQ:501 Type1 Active DFGin 7.13 14.609 BLAminus -126.41, -177.97 57.7, 79.82 -101.45, 23.66 290.45, 86.2 -71.99, -23.62 in-in in 8.254 Saltbr-in 2.826 HRD-in -67.73, -44.39 69.27, -21.51 in-in-in SNCiii in-in ActLoopNT-in 2.776 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.41, 162.2 APE9-dihe-na 76.62, 158.52 APE8-dihe-in -81.15, 137.38 APE8-rot-in 320.28 APE67-dihe-in -54.52, -12.47 -37.95, -53.62 APE12-dist-in 13.104 APE11-dist-in 11.291 APE10-dist-in 7.016 APE9-dist-in 3.21 None None None XRAY 2.32 0.204 0.234 A 339 331 3 0 0 0 [[161, 477]] 1.0 6fyo CMGC_CLK1_HUMAN CMGC 2e-93 318.8 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
5X8IA 154 481 484.0 SQZ:501 Type1 Active DFGin 7.353 13.999 BLAminus -122.66, 172.48 71.45, 69.85 -89.46, 19.16 303.2, 86.95 -71.61, -17.76 in-in in 8.379 Saltbr-in 2.542 HRD-in -68.32, -52.49 79.94, -11.57 in-in-in SNCiii in-in ActLoopNT-in 2.866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.32, 168.72 APE9-dihe-na 74.05, 158.08 APE8-dihe-in -81.53, 144.19 APE8-rot-in 300.53 APE67-dihe-in -65.15, -11.28 -51.71, -50.28 APE12-dist-in 13.083 APE11-dist-in 11.651 APE10-dist-in 7.533 APE9-dist-in 3.016 R432A None None XRAY 1.902 0.168 0.206 A 346 328 0 0 0 0 [[161, 477]] 1.0 5x8i CMGC_CLK1_HUMAN CMGC 2.7e-93 318.4 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
5X8IB 155 481 484.0 SQZ:501 Type1 Active DFGin 7.384 13.98 BLAminus -126.45, 170.69 71.83, 69.37 -88.36, 11.76 302.43, 89.48 -69.31, -18.97 in-in in 8.382 Saltbr-in 2.41 HRD-in -67.27, -52.41 79.09, -12.7 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.02, 169.54 APE9-dihe-na 72.76, 157.49 APE8-dihe-in -80.25, 143.44 APE8-rot-in 301.33 APE67-dihe-in -65.52, -10.3 -49.82, -50.77 APE12-dist-in 13.116 APE11-dist-in 11.677 APE10-dist-in 7.499 APE9-dist-in 3.017 R432A None None XRAY 1.902 0.168 0.206 B 346 327 0 0 0 0 [[161, 477]] 1.0 5x8i CMGC_CLK1_HUMAN CMGC 2.7e-93 318.4 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6YTGA 148 483 484.0 KHC:60501,KHC:60502 Type1,Allosteric Active DFGin 7.109 14.378 BLAminus -123.68, -179.19 66.81, 76.1 -102.89, 15.19 291.91, 90.06 -75.03, -12.8 in-in in 8.55 Saltbr-in 2.696 HRD-in -64.66, -54.29 85.54, -10.78 in-in-in SNCiii in-in ActLoopNT-in 2.832 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.45, 156.23 APE9-dihe-na 81.17, 153.49 APE8-dihe-in -77.75, 128.48 APE8-rot-in 300.43 APE67-dihe-in -69.97, -17.37 -12.96, -64.06 APE12-dist-in 13.337 APE11-dist-in 11.403 APE10-dist-in 7.756 APE9-dist-in 2.982 None None None XRAY 1.95 0.207 0.261 A 339 329 7 0 0 0 [[161, 477]] 1.0 6ytg CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6R8JA 152 481 484.0 JUW:501,JUW:502 Type1,Type1 Active DFGin 7.172 13.677 BLAminus -124.23, 172.49 72.75, 83.0 -102.73, 17.52 298.34, 101.12 -64.7, -21.81 in-in in 8.134 Saltbr-in 2.894 HRD-in -66.22, -54.05 83.24, -16.78 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.97, 169.66 APE9-dihe-na 75.96, 160.32 APE8-dihe-in -86.77, 141.55 APE8-rot-in 304.05 APE67-dihe-in -66.39, -13.17 -48.7, -48.98 APE12-dist-in 13.01 APE11-dist-in 11.527 APE10-dist-in 7.548 APE9-dist-in 2.981 None None None XRAY 1.75 0.218 0.263 A 337 330 0 0 0 0 [[161, 477]] 1.0 6r8j CMGC_CLK1_HUMAN CMGC 1.9e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6KHDC 150 479 484.0 3NG:1000 Type1 Inactive DFGin 7.026 14.412 ABAminus -125.6, -45.1 -89.27, 107.55 -111.64, 19.23 292.41, 98.32 -77.1, 0.74 in-in in 8.767 Saltbr-in 2.904 HRD-in -53.74, -54.41 89.98, -20.88 in-in-out SNCiio in-out ActLoopNT-in 2.895 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -118.02, -81.8 APE9-dihe-na -80.38, 126.35 APE8-dihe-in -130.72, 139.1 APE8-rot-out 73.02 APE67-dihe-in -49.48, -32.44 -62.98, -36.18 APE12-dist-in 13.371 APE11-dist-in 9.097 APE10-dist-out 11.33 APE9-dist-out 7.849 None None None XRAY 2.7 0.204 0.274 C 484 325 5 0 0 0 [[161, 477]] 1.0 6khd CMGC_CLK1_HUMAN CMGC 8.2e-93 317.4 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
AF-P49759-K1A 153 484 484.0 No_ligand No_ligand Inactive DFGin 7.074 14.19 BLAminus -127.24, 176.41 62.19, 72.99 -88.32, 9.55 297.11, 102.62 -68.31, -9.87 in-in in 8.451 Saltbr-in 2.696 HRD-in -72.36, -39.16 64.91, -10.55 in-in-out SNCiio in-out ActLoopNT-in 2.909 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -123.01, 174.5 APE9-dihe-na 65.72, 145.79 APE8-dihe-in -57.06, 135.18 APE8-rot-in 292.86 APE67-dihe-in -70.16, -18.82 -51.52, -41.74 APE12-dist-out 14.11 APE11-dist-in 11.835 APE10-dist-in 7.582 APE9-dist-in 2.907 None None None AF2 -1.0 1.0 1.0 A 332 332 0 0 0 0 [[161, 477]] 1.0 AF-P49759-K1 CMGC_CLK1_HUMAN CMGC 1.8e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
2VAGA 148 481 484.0 V25:61482 Type1 Inactive DFGin 7.108 14.026 BLAminus -129.43, 175.64 66.18, 85.97 -104.96, 23.22 293.24, 95.17 -73.67, -15.41 in-in in 8.37 Saltbr-in 2.627 HRD-in -71.48, -53.18 82.14, -13.71 in-in-out SNCiio in-out ActLoopNT-in 2.844 ActLoopCT-out nonTYR APEdihe_aaino APEdist_oioo APE10-dihe-na -88.11, 138.68 APE9-dihe-na -83.4, -165.24 APE8-dihe-in -49.62, 134.22 APE8-rot-none 999.0 APE67-dihe-out -47.82, -50.26 -151.88, 142.32 APE12-dist-out 14.065 APE11-dist-in 12.864 APE10-dist-out 9.777 APE9-dist-out 8.618 None SEP341,TPO342 SEP341,TPO342 XRAY 1.8 0.182 0.225 A 339 331 3 0 0 0 [[161, 477]] 1.0 2vag CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
5J1VC 148 483 484.0 6FD:60501 Type1 Inactive DFGin 7.065 14.186 BLAminus -127.76, 172.5 71.94, 87.97 -108.84, 22.87 296.53, 88.54 -79.84, -9.02 in-in in 8.535 Saltbr-in 2.747 HRD-in -76.64, -52.07 83.95, -17.44 in-in-out SNCiio in-out ActLoopNT-in 2.893 ActLoopCT-out nonTYR APEdihe_aannn APEdist_oion APE10-dihe-na -156.89, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -20.42 999.0, 999.0 APE12-dist-out 14.251 APE11-dist-in 11.602 APE10-dist-out 9.681 APE9-dist-none 999.0 None None None XRAY 2.52 0.201 0.244 C 339 312 24 0 0 3 [[161, 477]] 1.0 5j1v CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6FT9C 148 482 484.0 E6W:60501 Type1 Inactive DFGin 7.214 14.253 BLAminus -122.85, 177.29 65.92, 85.07 -105.77, 22.23 295.06, 82.45 -71.81, -8.98 in-in in 8.369 Saltbr-in 2.671 HRD-in -69.43, -51.23 80.08, -14.43 in-in-out SNCiio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oioo APE10-dihe-na -129.97, 131.35 APE9-dihe-na -47.51, 149.39 APE8-dihe-in -75.79, 135.36 APE8-rot-in 303.89 APE67-dihe-out -54.68, -26.4 -154.15, 148.3 APE12-dist-out 14.739 APE11-dist-in 12.427 APE10-dist-out 9.694 APE9-dist-out 8.702 None None None XRAY 1.87 0.168 0.202 C 339 335 0 0 0 0 [[161, 477]] 1.0 6ft9 CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6G33A 148 482 484.0 5ID:60501 Type1 Inactive DFGin 7.039 14.029 BLAminus -127.31, 176.31 68.38, 85.72 -104.03, 25.47 298.82, 93.66 -74.89, -17.97 in-in in 8.382 Saltbr-in 2.725 HRD-in -70.1, -50.84 78.28, -13.18 in-in-out SNCiio in-out ActLoopNT-in 2.848 ActLoopCT-out nonTYR APEdihe_aaino APEdist_oioo APE10-dihe-na -128.78, 136.1 APE9-dihe-na -77.1, 148.33 APE8-dihe-in -66.51, 123.5 APE8-rot-none 999.0 APE67-dihe-out -66.2, -20.29 -135.8, 167.22 APE12-dist-out 14.701 APE11-dist-in 12.354 APE10-dist-out 9.499 APE9-dist-out 8.8 None SEP341,TPO342 SEP341,TPO342 XRAY 2.05 0.19 0.218 A 339 335 0 0 0 0 [[161, 477]] 1.0 6g33 CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6G33B 148 482 484.0 5ID:60501 Type1 Inactive DFGin 7.077 13.979 BLAminus -125.16, 175.81 68.83, 87.13 -106.27, 24.24 297.31, 93.02 -76.58, -16.07 in-in in 8.386 Saltbr-in 2.7 HRD-in -69.85, -51.6 75.98, -11.49 in-in-out SNCiio in-out ActLoopNT-in 2.879 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -123.97, 135.36 APE9-dihe-na -72.42, 114.42 APE8-dihe-in -42.53, 141.22 APE8-rot-in 302.44 APE67-dihe-out -66.45, -16.55 -136.36, 149.49 APE12-dist-in 13.884 APE11-dist-in 11.906 APE10-dist-out 10.349 APE9-dist-out 9.743 None None None XRAY 2.05 0.19 0.218 B 339 335 0 0 0 0 [[161, 477]] 1.0 6g33 CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6G33C 148 482 484.0 5ID:60501 Type1 Inactive DFGin 7.153 14.05 BLAminus -127.31, 175.45 68.57, 84.45 -104.42, 25.23 297.23, 96.23 -74.84, -18.72 in-in in 8.43 Saltbr-in 2.707 HRD-in -68.44, -51.98 75.83, -9.76 in-in-out SNCiio in-out ActLoopNT-in 2.833 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioi APE10-dihe-na -158.67, 144.43 APE9-dihe-na 80.91, 147.02 APE8-dihe-in -56.89, 133.87 APE8-rot-none 999.0 APE67-dihe-in -70.75, -20.64 -58.82, -30.99 APE12-dist-out 14.13 APE11-dist-in 11.464 APE10-dist-out 8.215 APE9-dist-in 3.07 None None None XRAY 2.05 0.19 0.218 C 339 335 0 0 0 0 [[161, 477]] 1.0 6g33 CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6I5KA 148 482 484.0 H3H:60503 Type1 Inactive DFGin 7.019 14.281 BLAminus -127.95, 177.21 67.34, 85.43 -106.5, 25.82 299.72, 92.63 -80.22, -14.39 in-in in 8.899 Saltbr-in 2.673 HRD-in -72.89, -48.86 76.37, -11.75 in-in-out SNCiio in-out ActLoopNT-in 3.008 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oioo APE10-dihe-na -139.66, 157.93 APE9-dihe-na -83.57, -145.55 APE8-dihe-in -77.05, 120.2 APE8-rot-in 311.82 APE67-dihe-out -112.74, 31.9 -178.22, 144.22 APE12-dist-out 14.395 APE11-dist-in 12.617 APE10-dist-out 8.767 APE9-dist-out 8.726 None None None XRAY 2.3 0.197 0.224 A 339 335 0 0 0 0 [[161, 477]] 1.0 6i5k CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6I5LA 148 483 484.0 H3Q:60503 Type1 Inactive DFGin 6.915 14.32 BLAminus -124.28, 177.5 67.34, 93.35 -114.57, 21.88 295.56, 86.41 -76.53, -21.33 in-in in 8.845 Saltbr-in 2.712 HRD-in -70.91, -49.07 76.68, -14.69 in-in-out SNCiio in-out ActLoopNT-in 3.01 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oioo APE10-dihe-na -133.89, 159.24 APE9-dihe-na -106.72, -141.34 APE8-dihe-in -74.35, 99.26 APE8-rot-in 314.71 APE67-dihe-out -134.72, 40.5 -167.53, 148.17 APE12-dist-out 14.551 APE11-dist-in 12.28 APE10-dist-out 9.556 APE9-dist-out 8.853 None None None XRAY 2.55 0.195 0.221 A 339 336 0 0 0 0 [[161, 477]] 1.0 6i5l CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6Q8PB 148 483 484.0 HQB:60501 Type1 Inactive DFGin 6.666 14.081 BLAminus -123.82, 175.86 66.42, 98.63 -122.53, 30.35 298.66, 86.39 -77.45, -10.39 in-in in 8.788 Saltbr-in 2.993 HRD-in -68.29, -44.12 72.95, -22.76 in-in-out SNCiio in-out ActLoopNT-in 3.012 ActLoopCT-out nonTYR APEdihe_aannn APEdist_oion APE10-dihe-na -125.35, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.69, -36.51 999.0, -33.63 APE12-dist-out 14.435 APE11-dist-in 12.41 APE10-dist-out 9.398 APE9-dist-none 999.0 None None None XRAY 3.0 0.201 0.244 B 339 331 5 0 0 2 [[161, 477]] 1.0 6q8p CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6RAAA 148 481 484.0 JWN:60501 Type1 Inactive DFGin 6.887 13.755 BLAminus -129.66, 171.4 69.19, 92.86 -107.95, 20.85 301.15, 106.22 -67.28, -18.14 in-in in 8.302 Saltbr-in 2.917 HRD-in -72.74, -49.16 79.77, -9.47 in-in-out SNCiio in-out ActLoopNT-in 2.928 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.73, 160.54 APE9-dihe-na 78.15, 152.31 APE8-dihe-in -85.85, 139.96 APE8-rot-out 71.85 APE67-dihe-in -63.36, -27.28 -38.74, -49.54 APE12-dist-in 13.279 APE11-dist-in 11.314 APE10-dist-in 7.292 APE9-dist-in 3.081 None None None XRAY 2.1 0.19 0.233 A 339 334 0 0 0 0 [[161, 477]] 1.0 6raa CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6TW2E 148 484 484.0 V25:62301 Type1 Inactive DFGin 7.105 14.057 BLAminus -132.08, 175.35 68.1, 86.44 -104.28, 22.11 293.58, 88.16 -72.28, -16.22 in-in in 8.371 Saltbr-in 2.607 HRD-in -73.71, -50.29 77.69, -11.9 in-in-out SNCiio in-out ActLoopNT-in 2.874 ActLoopCT-out nonTYR APEdihe_aanao APEdist_oioo APE10-dihe-na -119.46, 133.12 APE9-dihe-na 999.0, -6.85 APE8-dihe-none 999.0, 103.3 APE8-rot-na 296.95 APE67-dihe-out -59.07, -41.0 14.44, 142.85 APE12-dist-out 14.85 APE11-dist-in 13.583 APE10-dist-out 9.947 APE9-dist-out 8.792 None SEP341,TPO342 SEP341,TPO342 XRAY 1.8 0.183 0.223 E 339 333 4 0 0 0 [[161, 477]] 1.0 6tw2 CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6Z50A 149 481 484.0 Q7K:501 Type1 Inactive DFGin 7.448 14.951 BLAminus -124.17, 179.68 61.85, 81.91 -99.95, 20.34 287.34, 80.47 -70.86, -16.42 in-out in 8.71 Saltbr-out 4.478 HRD-in -69.04, -50.58 79.9, -14.59 out-in-in SNCoii in-in ActLoopNT-in 2.964 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.92, 168.17 APE9-dihe-na 76.04, 153.68 APE8-dihe-in -72.55, 139.47 APE8-rot-in 294.1 APE67-dihe-in -67.47, -19.59 -46.45, -46.57 APE12-dist-in 13.543 APE11-dist-in 11.544 APE10-dist-in 7.517 APE9-dist-in 2.989 None None None XRAY 1.6 0.152 0.179 A 339 333 0 0 0 0 [[161, 477]] 1.0 6z50 CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
8P04A 148 481 484.0 WAK:60501 Type1 Inactive DFGin 6.771 13.658 BLAminus -133.01, 172.38 67.05, 96.19 -115.13, 17.91 300.74, 102.47 -73.76, -12.51 in-in in 8.467 Saltbr-in 2.843 HRD-in -68.49, -47.59 68.4, -9.92 in-in-out SNCiio in-out ActLoopNT-in 2.926 ActLoopCT-out nonTYR APEdihe_aaono APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 12.77 APE8-dihe-out 175.17, 160.57 APE8-rot-none 999.0 APE67-dihe-out -106.6, 0.77 -150.85, -100.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.637 None None None XRAY 2.6 0.212 0.259 A 339 320 14 0 0 6 [[161, 477]] 1.0 8p04 CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
8P08A 148 481 484.0 WAZ:60501 Type1 Inactive DFGin 6.917 13.825 BLAminus -129.66, 178.06 64.59, 93.43 -115.04, 31.69 303.49, 95.34 -73.89, -25.33 in-in in 8.624 Saltbr-in 2.677 HRD-in -76.48, -42.72 69.48, -15.82 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iioo APE10-dihe-na -73.7, -173.61 APE9-dihe-na -62.64, 77.27 APE8-dihe-out -66.74, -40.98 APE8-rot-in 246.46 APE67-dihe-out -59.36, 9.02 163.87, 172.03 APE12-dist-in 12.905 APE11-dist-in 9.203 APE10-dist-out 8.846 APE9-dist-out 9.021 None None None XRAY 2.4 0.211 0.26 A 339 334 0 0 0 0 [[161, 477]] 1.0 8p08 CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
8UWNA 148 482 484.0 XQX:1002 Type1 Inactive DFGin 6.969 14.292 BLAminus -127.28, 178.92 66.55, 91.52 -112.74, 24.76 300.27, 94.07 -77.25, -18.47 in-in in 8.725 Saltbr-in 2.692 HRD-in -67.24, -52.59 80.23, -15.08 in-in-out SNCiio in-out ActLoopNT-in 2.95 ActLoopCT-out nonTYR APEdihe_aaino APEdist_oioo APE10-dihe-na -75.07, 130.75 APE9-dihe-na -78.49, -168.23 APE8-dihe-in -60.11, 132.08 APE8-rot-none 999.0 APE67-dihe-out -60.44, -48.1 -144.72, 138.81 APE12-dist-out 14.6 APE11-dist-in 13.749 APE10-dist-out 10.088 APE9-dist-out 8.851 None SEP341,TPO342 SEP341,TPO342 XRAY 1.8 0.18 0.24 A 360 335 0 0 0 0 [[161, 477]] 1.0 8uwn CMGC_CLK1_HUMAN CMGC 3.1e-93 318.2 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6KHDB 149 482 484.0 3NG:1000 Type1 Inactive DFGin 6.908 14.076 BLAminus -116.48, -175.0 67.35, 80.01 -102.96, 15.9 292.23, 100.48 -53.02, -40.84 in-in in 8.583 Saltbr-in 2.636 HRD-in -57.21, -57.72 79.07, -3.09 in-in-out SNCiio in-out ActLoopNT-in 2.918 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -136.88, 104.05 APE9-dihe-na 173.26, -145.7 APE8-dihe-in -145.78, 56.63 APE8-rot-in 325.36 APE67-dihe-out -165.57, -36.7 24.99, 58.5 APE12-dist-in 13.582 APE11-dist-in 11.89 APE10-dist-in 6.825 APE9-dist-in 3.747 None None None XRAY 2.7 0.204 0.274 B 484 332 2 0 0 0 [[161, 477]] 1.0 6khd CMGC_CLK1_HUMAN CMGC 8.2e-93 317.4 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
5J1WC 148 483 484.0 6FB:60505,6FB:60506 Type1,Allosteric Inactive DFGin 7.143 14.286 BLAminus -122.18, 173.27 71.94, 86.76 -106.83, 22.04 296.04, 87.14 -77.19, -12.48 in-in in 8.504 Saltbr-in 2.568 HRD-in -74.28, -51.47 84.87, -18.08 in-in-out SNCiio in-out ActLoopNT-in 2.88 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oioo APE10-dihe-na -128.25, 150.31 APE9-dihe-na -78.45, -169.37 APE8-dihe-in -56.02, 117.75 APE8-rot-in 301.81 APE67-dihe-out -74.26, -11.87 -128.54, 128.96 APE12-dist-out 14.754 APE11-dist-in 12.334 APE10-dist-out 9.21 APE9-dist-out 8.676 None None None XRAY 2.42 0.191 0.228 C 339 314 22 0 0 0 [[161, 477]] 1.0 5j1w CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6KHDA 149 481 484.0 3NG:1000 Type1 Inactive DFGin 6.862 14.485 None -115.36, -74.37 -61.99, 112.36 -110.01, 19.25 292.55, 104.1 -59.59, -27.31 in-in in 8.753 Saltbr-in 2.455 HRD-in -79.61, -40.92 65.39, -11.49 in-in-out SNCiio in-out ActLoopNT-in 2.98 ActLoopCT-out nonTYR APEdihe_aannn APEdist_ioon APE10-dihe-na -162.31, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -85.78, 10.46 999.0, -15.39 APE12-dist-in 11.868 APE11-dist-out 7.043 APE10-dist-out 11.635 APE9-dist-none 999.0 None None None XRAY 2.7 0.204 0.274 A 484 322 11 0 0 2 [[161, 477]] 1.0 6khd CMGC_CLK1_HUMAN CMGC 8.2e-93 317.4 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6Q8PA 148 482 484.0 HQB:60501 Type1 None DFGin 7.111 14.533 BLAminus -124.47, -177.12 56.99, 94.11 -115.67, 29.05 294.23, 87.9 -80.98, -10.13 in-in in 9.013 Saltbr-in 3.418 HRD-in -77.51, -42.79 69.43, -19.47 in-in-none SNCiin in-none ActLoopNT-in 3.131 ActLoopCT-none nonTYR APEdihe_aanii APEdist_iiin APE10-dihe-na -135.51, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.79 APE8-rot-in 323.11 APE67-dihe-in -68.72, -18.82 -64.59, -40.03 APE12-dist-in 13.204 APE11-dist-in 11.201 APE10-dist-in 7.288 APE9-dist-none 999.0 None None None XRAY 3.0 0.201 0.244 A 339 334 1 0 0 1 [[161, 477]] 1.0 6q8p CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
6Q8PC 148 483 484.0 HQB:60501 Type1 None DFGin 7.261 13.945 BLAminus -128.5, 178.53 59.41, 97.23 -121.71, 37.79 304.27, 105.41 -86.72, -22.18 in-in in 8.676 Saltbr-in 3.006 HRD-in -68.24, -39.01 69.57, -23.21 in-in-none SNCiin in-none ActLoopNT-in 2.953 ActLoopCT-none nonTYR APEdihe_aanii APEdist_iiin APE10-dihe-na -136.11, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.77 APE8-rot-in 314.52 APE67-dihe-in -61.24, -29.44 -57.39, -46.95 APE12-dist-in 13.763 APE11-dist-in 11.126 APE10-dist-in 7.295 APE9-dist-none 999.0 None None None XRAY 3.0 0.201 0.244 C 339 333 3 0 0 1 [[161, 477]] 1.0 6q8p CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1

CMGC_CLK1 (Dual specificity protein kinase CLK1)

Total number of chains: 77
Active chains: 45
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 75 97.4% AF-P49759-K3A
DFGin ABAminus 1 1.3% 6KHDC
DFGin None 1 1.3% 6KHDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CLK1_HUMAN AF-P49759-K3A P49759 153 484 484.0 No_ligand No_ligand Active DFGin 6.943 14.15 BLAminus -132.48, 177.39 60.27, 71.57 -85.18, 10.53 300.3, 105.86 -66.37, -11.95 in-in in 8.442 Saltbr-in 2.717 HRD-in -74.62, -35.37 68.27, -12.7 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.72, 174.26 APE9-dihe-na 63.43, 136.97 APE8-dihe-in -54.83, 138.19 APE8-rot-in 291.39 APE67-dihe-in -67.82, -20.27 -52.33, -42.8 APE12-dist-in 13.892 APE11-dist-in 11.523 APE10-dist-in 7.732 APE9-dist-in 3.006 None None None AF2 -1.0 1.0 1.0 A 332 332 0 0 0 0 [[161, 477]] 1.0 AF-P49759-K3 Homo sapiens CMGC_CLK1_HUMAN CMGC 1.8e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6YTDA P49759 148 484 484.0 EAE:60501 Type1 Active DFGin 7.218 14.624 BLAminus -129.04, -179.37 68.43, 75.26 -99.43, 5.66 289.75, 100.38 -57.22, -23.43 in-in in 8.789 Saltbr-in 2.743 HRD-in -67.84, -52.77 79.42, -15.7 in-in-in SNCiii in-in ActLoopNT-in 2.956 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.91, 160.56 APE9-dihe-na 78.51, 152.43 APE8-dihe-in -82.58, 136.21 APE8-rot-in 297.75 APE67-dihe-in -72.13, -8.69 -31.46, -59.55 APE12-dist-in 13.409 APE11-dist-in 11.117 APE10-dist-in 7.411 APE9-dist-in 2.986 V324A None None XRAY 2.0 0.182 0.228 A 339 337 0 0 0 0 [[161, 477]] 1.0 6ytd Homo sapiens CMGC_CLK1_HUMAN CMGC 1.5e-93 319.2 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6QTYA P49759 149 481 484.0 V25:501 Type1 Active DFGin 7.189 13.828 BLAminus -129.69, 172.83 71.11, 83.55 -99.13, 16.45 297.38, 96.6 -71.94, -15.11 in-in in 8.324 Saltbr-in 2.651 HRD-in -69.24, -51.3 77.68, -14.79 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.16, 166.1 APE9-dihe-na 76.64, 158.21 APE8-dihe-in -87.0, 137.14 APE8-rot-in 293.42 APE67-dihe-in -62.6, -10.5 -44.79, -53.3 APE12-dist-in 12.981 APE11-dist-in 11.463 APE10-dist-in 7.478 APE9-dist-in 3.088 None None None XRAY 1.65 0.139 0.203 A 337 333 0 0 0 0 [[161, 477]] 1.0 6qty Homo sapiens CMGC_CLK1_HUMAN CMGC 1.9e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6R3DA P49759 152 481 484.0 JQW:901 Type1 Active DFGin 7.236 14.013 BLAminus -122.46, 176.35 64.69, 84.91 -101.75, 18.8 296.55, 100.55 -62.91, -23.24 in-in in 8.272 Saltbr-in 2.938 HRD-in -66.66, -51.76 77.65, -11.03 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.87, 173.33 APE9-dihe-na 73.0, 159.5 APE8-dihe-in -89.36, 141.36 APE8-rot-in 302.1 APE67-dihe-in -68.09, -12.73 -48.4, -46.85 APE12-dist-in 13.178 APE11-dist-in 11.688 APE10-dist-in 7.569 APE9-dist-in 2.994 None None None XRAY 1.85 0.223 0.265 A 337 330 0 0 0 0 [[161, 477]] 1.0 6r3d Homo sapiens CMGC_CLK1_HUMAN CMGC 1.9e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6R6EA P49759 153 481 484.0 JTQ:901 Type1 Active DFGin 7.288 14.296 BLAminus -128.0, 174.1 72.24, 79.12 -104.06, 19.03 290.47, 84.52 -68.66, -15.84 in-in in 8.409 Saltbr-in 2.745 HRD-in -60.82, -42.83 67.21, -15.33 in-in-in SNCiii in-in ActLoopNT-in 2.75 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.15, 166.85 APE9-dihe-na 79.69, 155.93 APE8-dihe-in -74.39, 146.66 APE8-rot-in 301.47 APE67-dihe-in -66.87, -19.64 -52.56, -47.56 APE12-dist-in 13.177 APE11-dist-in 11.708 APE10-dist-in 7.616 APE9-dist-in 3.091 None None None XRAY 2.25 0.209 0.258 A 337 327 2 0 0 0 [[161, 477]] 1.0 6r6e Homo sapiens CMGC_CLK1_HUMAN CMGC 1.9e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6R6XA P49759 152 481 484.0 JU8:901 Type1 Active DFGin 7.191 13.882 BLAminus -123.65, 175.5 67.74, 78.23 -100.49, 14.01 300.01, 96.17 -58.94, -19.36 in-in in 8.437 Saltbr-in 2.746 HRD-in -67.05, -47.28 77.18, -15.83 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.71, 173.64 APE9-dihe-na 76.22, 157.17 APE8-dihe-in -81.77, 144.6 APE8-rot-in 304.54 APE67-dihe-in -66.2, -13.27 -49.16, -50.71 APE12-dist-in 12.988 APE11-dist-in 11.623 APE10-dist-in 7.49 APE9-dist-in 3.042 None None None XRAY 2.05 0.201 0.247 A 337 330 0 0 0 0 [[161, 477]] 1.0 6r6x Homo sapiens CMGC_CLK1_HUMAN CMGC 1.9e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 7O9YA P49759 152 481 484.0 V5T:501 Type1 Active DFGin 7.246 13.687 BLAminus -122.5, 174.1 68.65, 82.2 -100.77, 14.37 301.76, 93.94 -56.91, -24.51 in-in in 8.153 Saltbr-in 2.762 HRD-in -69.77, -51.58 81.58, -12.75 in-in-in SNCiii in-in ActLoopNT-in 2.851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.84, 169.0 APE9-dihe-na 74.97, 161.24 APE8-dihe-in -86.97, 141.45 APE8-rot-in 302.46 APE67-dihe-in -63.2, -13.37 -47.79, -52.2 APE12-dist-in 12.972 APE11-dist-in 11.507 APE10-dist-in 7.486 APE9-dist-in 3.08 None None None XRAY 1.66 0.219 0.246 A 337 330 0 0 0 0 [[161, 477]] 1.0 7o9y Homo sapiens CMGC_CLK1_HUMAN CMGC 1.9e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 7OA0AAA P49759 152 481 484.0 JTQ:501 Type1 Active DFGin 7.208 13.869 BLAminus -123.62, 171.83 70.68, 87.81 -105.24, 18.66 295.8, 102.89 -75.22, -10.65 in-in in 8.248 Saltbr-in 2.75 HRD-in -68.11, -52.1 81.61, -13.16 in-in-in SNCiii in-in ActLoopNT-in 2.859 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.31, 171.34 APE9-dihe-na 77.29, 158.23 APE8-dihe-in -81.59, 143.88 APE8-rot-in 304.32 APE67-dihe-in -62.82, -8.69 -51.01, -53.79 APE12-dist-in 13.049 APE11-dist-in 11.57 APE10-dist-in 7.474 APE9-dist-in 3.03 None None None XRAY 1.81 0.195 0.242 AAA 337 330 0 0 0 0 [[161, 477]] 1.0 7oa0 Homo sapiens CMGC_CLK1_HUMAN CMGC 1.9e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 1Z57A P49759 148 482 484.0 DBQ:60001 Type1 Active DFGin 6.981 14.002 BLAminus -125.78, 172.53 74.79, 89.46 -108.53, 21.5 296.6, 99.61 -72.51, -21.17 in-in in 8.466 Saltbr-in 2.788 HRD-in -70.25, -52.83 80.14, -14.55 in-in-in SNCiii in-in ActLoopNT-in 2.943 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.0, 169.19 APE9-dihe-na 76.16, 157.77 APE8-dihe-in -82.83, 140.18 APE8-rot-in 294.7 APE67-dihe-in -63.99, -15.88 -47.28, -50.61 APE12-dist-in 13.322 APE11-dist-in 11.223 APE10-dist-in 7.313 APE9-dist-in 3.001 None None None XRAY 1.7 0.14 0.186 A 339 331 4 0 0 0 [[161, 477]] 1.0 1z57 Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 5J1VA P49759 148 483 484.0 6FD:60501 Type1 Active DFGin 7.1 14.172 BLAminus -126.87, 172.93 72.75, 87.91 -109.91, 21.95 296.61, 87.13 -77.69, -9.89 in-in in 8.527 Saltbr-in 2.736 HRD-in -74.36, -52.4 82.96, -16.81 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.9, 168.51 APE9-dihe-na 72.23, 149.39 APE8-dihe-in -71.93, 136.52 APE8-rot-in 285.15 APE67-dihe-in -66.67, -20.56 -35.82, -53.71 APE12-dist-in 13.528 APE11-dist-in 11.444 APE10-dist-in 7.281 APE9-dist-in 3.043 None None None XRAY 2.52 0.201 0.244 A 339 336 0 0 0 0 [[161, 477]] 1.0 5j1v Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 5J1VB P49759 148 482 484.0 6FD:60501 Type1 Active DFGin 7.109 14.12 BLAminus -126.74, 175.0 70.24, 87.64 -108.44, 20.05 295.73, 90.04 -77.7, -8.55 in-in in 8.576 Saltbr-in 2.754 HRD-in -73.08, -51.15 80.15, -14.17 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.41, 168.72 APE9-dihe-na 72.72, 151.05 APE8-dihe-in -70.92, 135.35 APE8-rot-in 286.36 APE67-dihe-in -65.82, -21.41 -37.05, -51.94 APE12-dist-in 13.782 APE11-dist-in 11.542 APE10-dist-in 7.356 APE9-dist-in 3.05 None None None XRAY 2.52 0.201 0.244 B 339 335 0 0 0 0 [[161, 477]] 1.0 5j1v Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 5J1WA P49759 148 483 484.0 6FB:60506 Type1 Active DFGin 7.172 14.326 BLAminus -121.81, 173.7 71.87, 86.58 -105.02, 20.94 296.61, 84.3 -77.49, -14.22 in-in in 8.549 Saltbr-in 2.564 HRD-in -71.53, -50.92 81.49, -14.91 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.47, 167.51 APE9-dihe-na 77.02, 140.17 APE8-dihe-in -56.28, 137.97 APE8-rot-in 295.84 APE67-dihe-in -62.06, -22.4 -61.94, -35.28 APE12-dist-in 13.605 APE11-dist-in 11.437 APE10-dist-in 7.252 APE9-dist-in 3.042 None None None XRAY 2.42 0.191 0.228 A 339 336 0 0 0 0 [[161, 477]] 1.0 5j1w Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 5J1WB P49759 148 482 484.0 6FB:60503 Type1 Active DFGin 7.29 14.265 BLAminus -120.99, 173.46 72.42, 86.12 -105.34, 21.92 296.07, 87.01 -75.02, -15.34 in-in in 8.585 Saltbr-in 2.585 HRD-in -69.32, -50.91 80.3, -14.73 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.41, 167.18 APE9-dihe-na 77.9, 139.82 APE8-dihe-in -54.28, 138.17 APE8-rot-in 296.7 APE67-dihe-in -62.44, -21.37 -62.69, -34.82 APE12-dist-in 13.648 APE11-dist-in 11.342 APE10-dist-in 7.196 APE9-dist-in 3.035 None None None XRAY 2.42 0.191 0.228 B 339 335 0 0 0 0 [[161, 477]] 1.0 5j1w Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6FT8A P49759 148 483 484.0 E6T:60501 Type1 Active DFGin 7.042 14.153 BLAminus -123.69, 179.12 66.02, 80.75 -102.66, 23.58 296.94, 92.84 -75.28, -12.2 in-in in 8.448 Saltbr-in 2.743 HRD-in -68.91, -53.98 78.36, -16.69 in-in-in SNCiii in-in ActLoopNT-in 2.941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.28, 167.17 APE9-dihe-na 78.21, 159.73 APE8-dihe-in -85.1, 140.33 APE8-rot-in 293.05 APE67-dihe-in -66.99, -12.12 -49.73, -45.92 APE12-dist-in 13.282 APE11-dist-in 11.517 APE10-dist-in 7.327 APE9-dist-in 3.029 None None None XRAY 1.45 0.166 0.195 A 339 336 0 0 0 0 [[161, 477]] 1.0 6ft8 Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6FT9A P49759 148 482 484.0 E6W:60501 Type1 Active DFGin 7.232 14.3 BLAminus -125.02, 175.42 67.64, 86.22 -106.42, 22.86 292.22, 81.03 -75.21, -13.41 in-in in 8.43 Saltbr-in 2.712 HRD-in -69.31, -51.72 79.55, -13.59 in-in-in SNCiii in-in ActLoopNT-in 2.866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.87, 168.01 APE9-dihe-na 73.7, 150.41 APE8-dihe-in -70.08, 140.16 APE8-rot-in 296.52 APE67-dihe-in -66.14, -21.84 -44.66, -47.8 APE12-dist-in 13.556 APE11-dist-in 11.218 APE10-dist-in 7.279 APE9-dist-in 2.933 None None None XRAY 1.87 0.168 0.202 A 339 335 0 0 0 0 [[161, 477]] 1.0 6ft9 Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6FT9B P49759 148 482 484.0 E6W:60501 Type1 Active DFGin 7.294 14.314 BLAminus -123.52, 178.1 65.34, 85.29 -106.33, 21.22 292.88, 84.42 -75.16, -8.95 in-in in 8.486 Saltbr-in 2.708 HRD-in -71.01, -50.08 80.37, -13.57 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.43, 168.15 APE9-dihe-na 75.76, 149.1 APE8-dihe-in -68.06, 138.01 APE8-rot-in 296.86 APE67-dihe-in -65.44, -22.15 -43.68, -46.72 APE12-dist-in 13.745 APE11-dist-in 11.277 APE10-dist-in 7.284 APE9-dist-in 2.966 None None None XRAY 1.87 0.168 0.202 B 339 335 0 0 0 0 [[161, 477]] 1.0 6ft9 Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6I5HA P49759 148 481 484.0 H3N:60507 Type1 Active DFGin 6.936 13.99 BLAminus -127.91, 175.49 70.62, 86.84 -104.99, 23.28 297.7, 98.27 -76.67, -15.26 in-in in 8.671 Saltbr-in 2.794 HRD-in -71.42, -54.52 81.98, -15.98 in-in-in SNCiii in-in ActLoopNT-in 2.989 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.5, 162.59 APE9-dihe-na 81.01, 150.81 APE8-dihe-in -73.05, 137.12 APE8-rot-in 298.85 APE67-dihe-in -65.31, -13.64 -50.7, -47.04 APE12-dist-in 12.982 APE11-dist-in 11.325 APE10-dist-in 7.234 APE9-dist-in 3.097 None None None XRAY 1.49 0.179 0.206 A 339 323 11 0 0 0 [[161, 477]] 1.0 6i5h Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6I5IA P49759 148 483 484.0 H3E:60501 Type1 Active DFGin 6.909 13.949 BLAminus -127.6, 172.7 71.85, 87.8 -102.42, 20.37 300.05, 101.13 -74.42, -16.22 in-in in 8.713 Saltbr-in 2.693 HRD-in -75.53, -52.34 81.22, -14.82 in-in-in SNCiii in-in ActLoopNT-in 2.998 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.19, 164.34 APE9-dihe-na 79.5, 152.78 APE8-dihe-in -78.57, 135.82 APE8-rot-in 292.41 APE67-dihe-in -65.9, -11.23 -46.6, -47.35 APE12-dist-in 13.114 APE11-dist-in 11.284 APE10-dist-in 7.252 APE9-dist-in 3.074 None None None XRAY 1.6 0.166 0.196 A 339 333 3 0 0 0 [[161, 477]] 1.0 6i5i Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6I5KB P49759 148 481 484.0 H3H:60504 Type1 Active DFGin 7.006 14.359 BLAminus -126.82, 178.06 66.53, 84.63 -104.0, 26.37 299.27, 91.89 -80.46, -16.31 in-in in 9.029 Saltbr-in 2.693 HRD-in -71.59, -48.77 75.18, -11.75 in-in-in SNCiii in-in ActLoopNT-in 2.984 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.96, 164.13 APE9-dihe-na 74.43, 150.15 APE8-dihe-in -66.68, 137.66 APE8-rot-in 303.78 APE67-dihe-in -77.74, -18.3 -54.0, -31.51 APE12-dist-in 13.844 APE11-dist-in 11.224 APE10-dist-in 7.395 APE9-dist-in 3.093 None None None XRAY 2.3 0.197 0.224 B 339 334 0 0 0 0 [[161, 477]] 1.0 6i5k Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6I5KC P49759 148 483 484.0 H3H:60504 Type1 Active DFGin 6.987 14.351 BLAminus -125.41, 178.1 66.91, 85.45 -105.62, 25.72 298.18, 84.65 -79.89, -19.48 in-in in 8.919 Saltbr-in 2.666 HRD-in -72.35, -49.89 76.53, -11.56 in-in-in SNCiii in-in ActLoopNT-in 3.001 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.9, 163.92 APE9-dihe-na 72.8, 149.97 APE8-dihe-in -66.75, 139.4 APE8-rot-in 303.5 APE67-dihe-in -77.85, -17.5 -52.64, -34.11 APE12-dist-in 13.616 APE11-dist-in 11.124 APE10-dist-in 7.341 APE9-dist-in 3.112 None None None XRAY 2.3 0.197 0.224 C 339 336 0 0 0 0 [[161, 477]] 1.0 6i5k Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6I5LB P49759 148 481 484.0 H3Q:60502 Type1 Active DFGin 6.928 14.418 BLAminus -123.55, 178.93 67.48, 93.05 -113.53, 21.71 295.78, 85.8 -74.38, -22.09 in-in in 8.982 Saltbr-in 2.74 HRD-in -69.85, -49.79 74.87, -13.88 in-in-in SNCiii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.82, 165.73 APE9-dihe-na 81.08, 146.54 APE8-dihe-in -62.76, 135.54 APE8-rot-in 302.63 APE67-dihe-in -68.98, -24.89 -54.53, -33.68 APE12-dist-in 13.852 APE11-dist-in 11.417 APE10-dist-in 7.226 APE9-dist-in 3.102 None None None XRAY 2.55 0.195 0.221 B 339 334 0 0 0 0 [[161, 477]] 1.0 6i5l Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6I5LC P49759 148 483 484.0 H3Q:60502 Type1 Active DFGin 6.913 14.384 BLAminus -123.57, 177.17 68.91, 92.22 -114.6, 21.5 296.12, 85.91 -74.75, -23.49 in-in in 8.878 Saltbr-in 2.711 HRD-in -71.08, -49.61 75.52, -13.95 in-in-in SNCiii in-in ActLoopNT-in 3.021 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.58, 165.38 APE9-dihe-na 80.23, 146.0 APE8-dihe-in -62.57, 137.3 APE8-rot-in 302.62 APE67-dihe-in -70.1, -23.69 -53.95, -35.33 APE12-dist-in 13.658 APE11-dist-in 11.337 APE10-dist-in 7.179 APE9-dist-in 3.136 None None None XRAY 2.55 0.195 0.221 C 339 336 0 0 0 0 [[161, 477]] 1.0 6i5l Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6Q8KA P49759 148 484 484.0 FG9:60502 Type1 Active DFGin 7.038 14.073 BLAminus -126.96, 173.92 68.96, 94.14 -110.91, 19.67 299.22, 86.31 -70.74, -15.36 in-in in 8.789 Saltbr-in 2.697 HRD-in -64.71, -54.26 80.91, -18.18 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.28, 157.45 APE9-dihe-na 83.98, 154.49 APE8-dihe-in -77.73, 126.84 APE8-rot-in 298.77 APE67-dihe-in -63.27, -22.97 -33.76, -49.02 APE12-dist-in 13.367 APE11-dist-in 11.286 APE10-dist-in 7.468 APE9-dist-in 3.111 None None None XRAY 2.29 0.191 0.259 A 339 337 0 0 0 0 [[161, 477]] 1.0 6q8k Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6YTAA P49759 148 483 484.0 IYZ:60702 Type1 Active DFGin 6.935 13.725 BLAminus -125.39, 175.02 66.16, 92.34 -102.15, 17.18 301.41, 98.15 -60.08, -20.3 in-in in 8.317 Saltbr-in 2.699 HRD-in -68.08, -57.05 83.09, -18.57 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.65, 155.94 APE9-dihe-na 83.67, 157.83 APE8-dihe-in -84.55, 129.06 APE8-rot-in 292.9 APE67-dihe-in -62.02, -24.22 -28.74, -53.35 APE12-dist-in 13.211 APE11-dist-in 11.663 APE10-dist-in 7.375 APE9-dist-in 3.159 None None None XRAY 2.3 0.194 0.275 A 339 336 0 0 0 0 [[161, 477]] 1.0 6yta Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6YTEC P49759 148 484 484.0 EAE:60501 Type1 Active DFGin 7.145 14.111 BLAminus -123.36, 172.5 72.26, 86.11 -107.09, 11.71 295.65, 98.47 -58.29, -17.8 in-in in 8.544 Saltbr-in 2.225 HRD-in -60.42, -59.86 88.88, -8.99 in-in-in SNCiii in-in ActLoopNT-in 3.005 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.24, 160.76 APE9-dihe-na 81.35, 157.72 APE8-dihe-in -87.96, 130.83 APE8-rot-in 293.05 APE67-dihe-in -54.77, -23.25 -31.22, -65.53 APE12-dist-in 13.375 APE11-dist-in 11.44 APE10-dist-in 7.321 APE9-dist-in 3.082 None None None XRAY 2.3 0.184 0.258 C 339 337 0 0 0 0 [[161, 477]] 1.0 6yte Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6YTIA P49759 150 482 484.0 7A7:605 Type1 Active DFGin 7.292 14.242 BLAminus -134.7, 172.33 69.03, 94.12 -110.31, 22.0 290.95, 98.93 -72.82, -22.05 in-in in 8.645 Saltbr-in 2.617 HRD-in -68.46, -54.35 84.41, -17.31 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.78, 154.97 APE9-dihe-na 84.02, 157.2 APE8-dihe-in -78.01, 116.07 APE8-rot-in 301.91 APE67-dihe-in -65.16, -18.0 -14.75, -58.2 APE12-dist-in 13.417 APE11-dist-in 11.037 APE10-dist-in 7.456 APE9-dist-in 3.02 None None None XRAY 2.4 0.198 0.256 A 339 329 4 0 0 0 [[161, 477]] 1.0 6yti Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6Z4ZA P49759 148 482 484.0 PQ5:60505 Type1 Active DFGin 7.046 14.236 BLAminus -126.68, 179.24 66.69, 82.0 -103.33, 19.73 297.68, 94.61 -71.59, -13.97 in-in in 8.461 Saltbr-in 2.764 HRD-in -69.38, -51.98 76.89, -13.79 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.91, 169.84 APE9-dihe-na 70.81, 154.45 APE8-dihe-in -79.18, 136.44 APE8-rot-in 295.15 APE67-dihe-in -64.16, -17.67 -45.6, -49.57 APE12-dist-in 13.513 APE11-dist-in 11.359 APE10-dist-in 7.327 APE9-dist-in 3.041 None None None XRAY 2.07 0.177 0.213 A 339 335 0 0 0 0 [[161, 477]] 1.0 6z4z Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6Z4ZB P49759 148 484 484.0 PQ5:60501 Type1 Active DFGin 7.048 14.168 BLAminus -127.78, 179.44 66.36, 84.49 -106.02, 23.22 298.83, 96.06 -73.86, -11.97 in-in in 8.421 Saltbr-in 2.725 HRD-in -70.61, -51.12 77.5, -15.65 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.17, 168.57 APE9-dihe-na 73.19, 152.9 APE8-dihe-in -77.75, 136.06 APE8-rot-in 294.47 APE67-dihe-in -61.42, -18.21 -47.63, -47.77 APE12-dist-in 13.485 APE11-dist-in 11.247 APE10-dist-in 7.219 APE9-dist-in 3.052 None None None XRAY 2.07 0.177 0.213 B 339 337 0 0 0 0 [[161, 477]] 1.0 6z4z Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6Z4ZC P49759 148 482 484.0 PQ5:60502 Type1 Active DFGin 7.108 14.249 BLAminus -126.87, 178.82 67.48, 81.17 -101.74, 18.48 298.94, 95.28 -65.75, -17.47 in-in in 8.567 Saltbr-in 2.763 HRD-in -67.93, -52.14 78.08, -12.45 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.01, 169.28 APE9-dihe-na 73.05, 151.25 APE8-dihe-in -74.69, 135.04 APE8-rot-in 294.69 APE67-dihe-in -63.57, -18.13 -46.66, -45.93 APE12-dist-in 13.708 APE11-dist-in 11.458 APE10-dist-in 7.407 APE9-dist-in 3.028 None None None XRAY 2.07 0.177 0.213 C 339 335 0 0 0 0 [[161, 477]] 1.0 6z4z Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6ZLNA P49759 148 484 484.0 PKB:60503 Type1 Active DFGin 7.006 14.192 BLAminus -125.63, 176.89 76.78, 75.35 -103.44, 16.76 293.35, 98.15 -70.81, -12.33 in-in in 8.663 Saltbr-in 2.707 HRD-in -67.73, -49.47 78.97, -14.05 in-in-in SNCiii in-in ActLoopNT-in 2.935 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.54, 162.21 APE9-dihe-na 79.84, 163.79 APE8-dihe-in -96.39, 123.92 APE8-rot-in 291.96 APE67-dihe-in -72.31, -12.72 -20.91, -56.58 APE12-dist-in 13.233 APE11-dist-in 10.924 APE10-dist-in 7.217 APE9-dist-in 3.092 None None None XRAY 1.7 0.171 0.199 A 339 337 0 0 0 0 [[161, 477]] 1.0 6zln Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 7AK3A P49759 148 483 484.0 RH8:60501 Type1 Active DFGin 7.32 14.284 BLAminus -128.56, 172.37 67.01, 84.33 -103.74, 27.34 296.18, 85.72 -72.52, -23.23 in-in in 8.603 Saltbr-in 2.865 HRD-in -61.61, -53.86 89.68, -14.81 in-in-in SNCiii in-in ActLoopNT-in 2.958 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.68, 162.47 APE9-dihe-na 75.05, 158.38 APE8-dihe-in -88.77, 128.79 APE8-rot-in 301.95 APE67-dihe-in -60.58, -28.09 -3.93, -77.31 APE12-dist-in 13.387 APE11-dist-in 11.15 APE10-dist-in 7.274 APE9-dist-in 2.998 None None None XRAY 2.5 0.213 0.26 A 339 336 0 0 0 0 [[161, 477]] 1.0 7ak3 Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 7OPGA P49759 148 482 484.0 06N:60501 Type1 Active DFGin 7.079 14.337 BLAminus -125.23, 174.99 68.34, 89.35 -108.55, 22.34 294.5, 84.43 -74.9, -16.57 in-in in 8.828 Saltbr-in 2.697 HRD-in -68.7, -53.19 79.41, -13.79 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.87, 169.9 APE9-dihe-na 72.2, 152.58 APE8-dihe-in -74.2, 140.4 APE8-rot-in 296.34 APE67-dihe-in -64.01, -18.08 -47.78, -49.23 APE12-dist-in 13.454 APE11-dist-in 11.205 APE10-dist-in 7.289 APE9-dist-in 3.014 None None None XRAY 1.93 0.176 0.208 A 339 335 0 0 0 0 [[161, 477]] 1.0 7opg Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 7OPGB P49759 148 483 484.0 06N:60501 Type1 Active DFGin 7.092 14.295 BLAminus -128.58, 171.98 71.57, 88.89 -110.25, 21.49 294.73, 85.57 -73.38, -14.32 in-in in 8.793 Saltbr-in 2.685 HRD-in -66.06, -53.32 81.87, -15.7 in-in-in SNCiii in-in ActLoopNT-in 2.843 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.09, 167.09 APE9-dihe-na 74.85, 150.04 APE8-dihe-in -76.84, 138.69 APE8-rot-in 295.58 APE67-dihe-in -61.09, -19.4 -51.05, -46.51 APE12-dist-in 13.276 APE11-dist-in 11.151 APE10-dist-in 7.227 APE9-dist-in 3.05 None None None XRAY 1.93 0.176 0.208 B 339 336 0 0 0 0 [[161, 477]] 1.0 7opg Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 7OPGC P49759 148 482 484.0 06N:60501 Type1 Active DFGin 7.14 14.318 BLAminus -126.92, 172.88 71.54, 91.0 -109.11, 17.42 294.29, 87.52 -72.35, -14.96 in-in in 8.898 Saltbr-in 2.703 HRD-in -68.36, -53.23 82.74, -14.25 in-in-in SNCiii in-in ActLoopNT-in 2.837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.58, 169.34 APE9-dihe-na 74.62, 150.8 APE8-dihe-in -72.07, 139.48 APE8-rot-in 296.41 APE67-dihe-in -63.14, -17.95 -50.02, -46.94 APE12-dist-in 13.459 APE11-dist-in 11.323 APE10-dist-in 7.383 APE9-dist-in 3.025 None None None XRAY 1.93 0.176 0.208 C 339 335 0 0 0 0 [[161, 477]] 1.0 7opg Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6FYOA P49759 148 481 484.0 EAQ:501 Type1 Active DFGin 7.13 14.609 BLAminus -126.41, -177.97 57.7, 79.82 -101.45, 23.66 290.45, 86.2 -71.99, -23.62 in-in in 8.254 Saltbr-in 2.826 HRD-in -67.73, -44.39 69.27, -21.51 in-in-in SNCiii in-in ActLoopNT-in 2.776 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.41, 162.2 APE9-dihe-na 76.62, 158.52 APE8-dihe-in -81.15, 137.38 APE8-rot-in 320.28 APE67-dihe-in -54.52, -12.47 -37.95, -53.62 APE12-dist-in 13.104 APE11-dist-in 11.291 APE10-dist-in 7.016 APE9-dist-in 3.21 None None None XRAY 2.32 0.204 0.234 A 339 331 3 0 0 0 [[161, 477]] 1.0 6fyo Homo sapiens CMGC_CLK1_HUMAN CMGC 2e-93 318.8 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 5X8IA P49759 154 481 484.0 SQZ:501 Type1 Active DFGin 7.353 13.999 BLAminus -122.66, 172.48 71.45, 69.85 -89.46, 19.16 303.2, 86.95 -71.61, -17.76 in-in in 8.379 Saltbr-in 2.542 HRD-in -68.32, -52.49 79.94, -11.57 in-in-in SNCiii in-in ActLoopNT-in 2.866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.32, 168.72 APE9-dihe-na 74.05, 158.08 APE8-dihe-in -81.53, 144.19 APE8-rot-in 300.53 APE67-dihe-in -65.15, -11.28 -51.71, -50.28 APE12-dist-in 13.083 APE11-dist-in 11.651 APE10-dist-in 7.533 APE9-dist-in 3.016 R432A None None XRAY 1.902 0.168 0.206 A 346 328 0 0 0 0 [[161, 477]] 1.0 5x8i Homo sapiens CMGC_CLK1_HUMAN CMGC 2.7e-93 318.4 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 5X8IB P49759 155 481 484.0 SQZ:501 Type1 Active DFGin 7.384 13.98 BLAminus -126.45, 170.69 71.83, 69.37 -88.36, 11.76 302.43, 89.48 -69.31, -18.97 in-in in 8.382 Saltbr-in 2.41 HRD-in -67.27, -52.41 79.09, -12.7 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.02, 169.54 APE9-dihe-na 72.76, 157.49 APE8-dihe-in -80.25, 143.44 APE8-rot-in 301.33 APE67-dihe-in -65.52, -10.3 -49.82, -50.77 APE12-dist-in 13.116 APE11-dist-in 11.677 APE10-dist-in 7.499 APE9-dist-in 3.017 R432A None None XRAY 1.902 0.168 0.206 B 346 327 0 0 0 0 [[161, 477]] 1.0 5x8i Homo sapiens CMGC_CLK1_HUMAN CMGC 2.7e-93 318.4 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6YTGA P49759 148 483 484.0 KHC:60501,KHC:60502 Type1,Allosteric Active DFGin 7.109 14.378 BLAminus -123.68, -179.19 66.81, 76.1 -102.89, 15.19 291.91, 90.06 -75.03, -12.8 in-in in 8.55 Saltbr-in 2.696 HRD-in -64.66, -54.29 85.54, -10.78 in-in-in SNCiii in-in ActLoopNT-in 2.832 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.45, 156.23 APE9-dihe-na 81.17, 153.49 APE8-dihe-in -77.75, 128.48 APE8-rot-in 300.43 APE67-dihe-in -69.97, -17.37 -12.96, -64.06 APE12-dist-in 13.337 APE11-dist-in 11.403 APE10-dist-in 7.756 APE9-dist-in 2.982 None None None XRAY 1.95 0.207 0.261 A 339 329 7 0 0 0 [[161, 477]] 1.0 6ytg Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6R8JA P49759 152 481 484.0 JUW:501,JUW:502 Type1,Type1 Active DFGin 7.172 13.677 BLAminus -124.23, 172.49 72.75, 83.0 -102.73, 17.52 298.34, 101.12 -64.7, -21.81 in-in in 8.134 Saltbr-in 2.894 HRD-in -66.22, -54.05 83.24, -16.78 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.97, 169.66 APE9-dihe-na 75.96, 160.32 APE8-dihe-in -86.77, 141.55 APE8-rot-in 304.05 APE67-dihe-in -66.39, -13.17 -48.7, -48.98 APE12-dist-in 13.01 APE11-dist-in 11.527 APE10-dist-in 7.548 APE9-dist-in 2.981 None None None XRAY 1.75 0.218 0.263 A 337 330 0 0 0 0 [[161, 477]] 1.0 6r8j Homo sapiens CMGC_CLK1_HUMAN CMGC 1.9e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6KHDC P49759 150 479 484.0 3NG:1000 Type1 Inactive DFGin 7.026 14.412 ABAminus -125.6, -45.1 -89.27, 107.55 -111.64, 19.23 292.41, 98.32 -77.1, 0.74 in-in in 8.767 Saltbr-in 2.904 HRD-in -53.74, -54.41 89.98, -20.88 in-in-out SNCiio in-out ActLoopNT-in 2.895 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -118.02, -81.8 APE9-dihe-na -80.38, 126.35 APE8-dihe-in -130.72, 139.1 APE8-rot-out 73.02 APE67-dihe-in -49.48, -32.44 -62.98, -36.18 APE12-dist-in 13.371 APE11-dist-in 9.097 APE10-dist-out 11.33 APE9-dist-out 7.849 None None None XRAY 2.7 0.204 0.274 C 484 325 5 0 0 0 [[161, 477]] 1.0 6khd Homo sapiens CMGC_CLK1_HUMAN CMGC 8.2e-93 317.4 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN AF-P49759-K1A P49759 153 484 484.0 No_ligand No_ligand Inactive DFGin 7.074 14.19 BLAminus -127.24, 176.41 62.19, 72.99 -88.32, 9.55 297.11, 102.62 -68.31, -9.87 in-in in 8.451 Saltbr-in 2.696 HRD-in -72.36, -39.16 64.91, -10.55 in-in-out SNCiio in-out ActLoopNT-in 2.909 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -123.01, 174.5 APE9-dihe-na 65.72, 145.79 APE8-dihe-in -57.06, 135.18 APE8-rot-in 292.86 APE67-dihe-in -70.16, -18.82 -51.52, -41.74 APE12-dist-out 14.11 APE11-dist-in 11.835 APE10-dist-in 7.582 APE9-dist-in 2.907 None None None AF2 -1.0 1.0 1.0 A 332 332 0 0 0 0 [[161, 477]] 1.0 AF-P49759-K1 Homo sapiens CMGC_CLK1_HUMAN CMGC 1.8e-93 318.9 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 2VAGA P49759 148 481 484.0 V25:61482 Type1 Inactive DFGin 7.108 14.026 BLAminus -129.43, 175.64 66.18, 85.97 -104.96, 23.22 293.24, 95.17 -73.67, -15.41 in-in in 8.37 Saltbr-in 2.627 HRD-in -71.48, -53.18 82.14, -13.71 in-in-out SNCiio in-out ActLoopNT-in 2.844 ActLoopCT-out nonTYR APEdihe_aaino APEdist_oioo APE10-dihe-na -88.11, 138.68 APE9-dihe-na -83.4, -165.24 APE8-dihe-in -49.62, 134.22 APE8-rot-none 999.0 APE67-dihe-out -47.82, -50.26 -151.88, 142.32 APE12-dist-out 14.065 APE11-dist-in 12.864 APE10-dist-out 9.777 APE9-dist-out 8.618 None SEP341,TPO342 SEP341,TPO342 XRAY 1.8 0.182 0.225 A 339 331 3 0 0 0 [[161, 477]] 1.0 2vag Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 5J1VC P49759 148 483 484.0 6FD:60501 Type1 Inactive DFGin 7.065 14.186 BLAminus -127.76, 172.5 71.94, 87.97 -108.84, 22.87 296.53, 88.54 -79.84, -9.02 in-in in 8.535 Saltbr-in 2.747 HRD-in -76.64, -52.07 83.95, -17.44 in-in-out SNCiio in-out ActLoopNT-in 2.893 ActLoopCT-out nonTYR APEdihe_aannn APEdist_oion APE10-dihe-na -156.89, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -20.42 999.0, 999.0 APE12-dist-out 14.251 APE11-dist-in 11.602 APE10-dist-out 9.681 APE9-dist-none 999.0 None None None XRAY 2.52 0.201 0.244 C 339 312 24 0 0 3 [[161, 477]] 1.0 5j1v Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6FT9C P49759 148 482 484.0 E6W:60501 Type1 Inactive DFGin 7.214 14.253 BLAminus -122.85, 177.29 65.92, 85.07 -105.77, 22.23 295.06, 82.45 -71.81, -8.98 in-in in 8.369 Saltbr-in 2.671 HRD-in -69.43, -51.23 80.08, -14.43 in-in-out SNCiio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oioo APE10-dihe-na -129.97, 131.35 APE9-dihe-na -47.51, 149.39 APE8-dihe-in -75.79, 135.36 APE8-rot-in 303.89 APE67-dihe-out -54.68, -26.4 -154.15, 148.3 APE12-dist-out 14.739 APE11-dist-in 12.427 APE10-dist-out 9.694 APE9-dist-out 8.702 None None None XRAY 1.87 0.168 0.202 C 339 335 0 0 0 0 [[161, 477]] 1.0 6ft9 Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6G33A P49759 148 482 484.0 5ID:60501 Type1 Inactive DFGin 7.039 14.029 BLAminus -127.31, 176.31 68.38, 85.72 -104.03, 25.47 298.82, 93.66 -74.89, -17.97 in-in in 8.382 Saltbr-in 2.725 HRD-in -70.1, -50.84 78.28, -13.18 in-in-out SNCiio in-out ActLoopNT-in 2.848 ActLoopCT-out nonTYR APEdihe_aaino APEdist_oioo APE10-dihe-na -128.78, 136.1 APE9-dihe-na -77.1, 148.33 APE8-dihe-in -66.51, 123.5 APE8-rot-none 999.0 APE67-dihe-out -66.2, -20.29 -135.8, 167.22 APE12-dist-out 14.701 APE11-dist-in 12.354 APE10-dist-out 9.499 APE9-dist-out 8.8 None SEP341,TPO342 SEP341,TPO342 XRAY 2.05 0.19 0.218 A 339 335 0 0 0 0 [[161, 477]] 1.0 6g33 Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6G33B P49759 148 482 484.0 5ID:60501 Type1 Inactive DFGin 7.077 13.979 BLAminus -125.16, 175.81 68.83, 87.13 -106.27, 24.24 297.31, 93.02 -76.58, -16.07 in-in in 8.386 Saltbr-in 2.7 HRD-in -69.85, -51.6 75.98, -11.49 in-in-out SNCiio in-out ActLoopNT-in 2.879 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -123.97, 135.36 APE9-dihe-na -72.42, 114.42 APE8-dihe-in -42.53, 141.22 APE8-rot-in 302.44 APE67-dihe-out -66.45, -16.55 -136.36, 149.49 APE12-dist-in 13.884 APE11-dist-in 11.906 APE10-dist-out 10.349 APE9-dist-out 9.743 None None None XRAY 2.05 0.19 0.218 B 339 335 0 0 0 0 [[161, 477]] 1.0 6g33 Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6G33C P49759 148 482 484.0 5ID:60501 Type1 Inactive DFGin 7.153 14.05 BLAminus -127.31, 175.45 68.57, 84.45 -104.42, 25.23 297.23, 96.23 -74.84, -18.72 in-in in 8.43 Saltbr-in 2.707 HRD-in -68.44, -51.98 75.83, -9.76 in-in-out SNCiio in-out ActLoopNT-in 2.833 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioi APE10-dihe-na -158.67, 144.43 APE9-dihe-na 80.91, 147.02 APE8-dihe-in -56.89, 133.87 APE8-rot-none 999.0 APE67-dihe-in -70.75, -20.64 -58.82, -30.99 APE12-dist-out 14.13 APE11-dist-in 11.464 APE10-dist-out 8.215 APE9-dist-in 3.07 None None None XRAY 2.05 0.19 0.218 C 339 335 0 0 0 0 [[161, 477]] 1.0 6g33 Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6I5KA P49759 148 482 484.0 H3H:60503 Type1 Inactive DFGin 7.019 14.281 BLAminus -127.95, 177.21 67.34, 85.43 -106.5, 25.82 299.72, 92.63 -80.22, -14.39 in-in in 8.899 Saltbr-in 2.673 HRD-in -72.89, -48.86 76.37, -11.75 in-in-out SNCiio in-out ActLoopNT-in 3.008 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oioo APE10-dihe-na -139.66, 157.93 APE9-dihe-na -83.57, -145.55 APE8-dihe-in -77.05, 120.2 APE8-rot-in 311.82 APE67-dihe-out -112.74, 31.9 -178.22, 144.22 APE12-dist-out 14.395 APE11-dist-in 12.617 APE10-dist-out 8.767 APE9-dist-out 8.726 None None None XRAY 2.3 0.197 0.224 A 339 335 0 0 0 0 [[161, 477]] 1.0 6i5k Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6I5LA P49759 148 483 484.0 H3Q:60503 Type1 Inactive DFGin 6.915 14.32 BLAminus -124.28, 177.5 67.34, 93.35 -114.57, 21.88 295.56, 86.41 -76.53, -21.33 in-in in 8.845 Saltbr-in 2.712 HRD-in -70.91, -49.07 76.68, -14.69 in-in-out SNCiio in-out ActLoopNT-in 3.01 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oioo APE10-dihe-na -133.89, 159.24 APE9-dihe-na -106.72, -141.34 APE8-dihe-in -74.35, 99.26 APE8-rot-in 314.71 APE67-dihe-out -134.72, 40.5 -167.53, 148.17 APE12-dist-out 14.551 APE11-dist-in 12.28 APE10-dist-out 9.556 APE9-dist-out 8.853 None None None XRAY 2.55 0.195 0.221 A 339 336 0 0 0 0 [[161, 477]] 1.0 6i5l Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6Q8PB P49759 148 483 484.0 HQB:60501 Type1 Inactive DFGin 6.666 14.081 BLAminus -123.82, 175.86 66.42, 98.63 -122.53, 30.35 298.66, 86.39 -77.45, -10.39 in-in in 8.788 Saltbr-in 2.993 HRD-in -68.29, -44.12 72.95, -22.76 in-in-out SNCiio in-out ActLoopNT-in 3.012 ActLoopCT-out nonTYR APEdihe_aannn APEdist_oion APE10-dihe-na -125.35, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.69, -36.51 999.0, -33.63 APE12-dist-out 14.435 APE11-dist-in 12.41 APE10-dist-out 9.398 APE9-dist-none 999.0 None None None XRAY 3.0 0.201 0.244 B 339 331 5 0 0 2 [[161, 477]] 1.0 6q8p Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6RAAA P49759 148 481 484.0 JWN:60501 Type1 Inactive DFGin 6.887 13.755 BLAminus -129.66, 171.4 69.19, 92.86 -107.95, 20.85 301.15, 106.22 -67.28, -18.14 in-in in 8.302 Saltbr-in 2.917 HRD-in -72.74, -49.16 79.77, -9.47 in-in-out SNCiio in-out ActLoopNT-in 2.928 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.73, 160.54 APE9-dihe-na 78.15, 152.31 APE8-dihe-in -85.85, 139.96 APE8-rot-out 71.85 APE67-dihe-in -63.36, -27.28 -38.74, -49.54 APE12-dist-in 13.279 APE11-dist-in 11.314 APE10-dist-in 7.292 APE9-dist-in 3.081 None None None XRAY 2.1 0.19 0.233 A 339 334 0 0 0 0 [[161, 477]] 1.0 6raa Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6TW2E P49759 148 484 484.0 V25:62301 Type1 Inactive DFGin 7.105 14.057 BLAminus -132.08, 175.35 68.1, 86.44 -104.28, 22.11 293.58, 88.16 -72.28, -16.22 in-in in 8.371 Saltbr-in 2.607 HRD-in -73.71, -50.29 77.69, -11.9 in-in-out SNCiio in-out ActLoopNT-in 2.874 ActLoopCT-out nonTYR APEdihe_aanao APEdist_oioo APE10-dihe-na -119.46, 133.12 APE9-dihe-na 999.0, -6.85 APE8-dihe-none 999.0, 103.3 APE8-rot-na 296.95 APE67-dihe-out -59.07, -41.0 14.44, 142.85 APE12-dist-out 14.85 APE11-dist-in 13.583 APE10-dist-out 9.947 APE9-dist-out 8.792 None SEP341,TPO342 SEP341,TPO342 XRAY 1.8 0.183 0.223 E 339 333 4 0 0 0 [[161, 477]] 1.0 6tw2 Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6Z50A P49759 149 481 484.0 Q7K:501 Type1 Inactive DFGin 7.448 14.951 BLAminus -124.17, 179.68 61.85, 81.91 -99.95, 20.34 287.34, 80.47 -70.86, -16.42 in-out in 8.71 Saltbr-out 4.478 HRD-in -69.04, -50.58 79.9, -14.59 out-in-in SNCoii in-in ActLoopNT-in 2.964 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.92, 168.17 APE9-dihe-na 76.04, 153.68 APE8-dihe-in -72.55, 139.47 APE8-rot-in 294.1 APE67-dihe-in -67.47, -19.59 -46.45, -46.57 APE12-dist-in 13.543 APE11-dist-in 11.544 APE10-dist-in 7.517 APE9-dist-in 2.989 None None None XRAY 1.6 0.152 0.179 A 339 333 0 0 0 0 [[161, 477]] 1.0 6z50 Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 8P04A P49759 148 481 484.0 WAK:60501 Type1 Inactive DFGin 6.771 13.658 BLAminus -133.01, 172.38 67.05, 96.19 -115.13, 17.91 300.74, 102.47 -73.76, -12.51 in-in in 8.467 Saltbr-in 2.843 HRD-in -68.49, -47.59 68.4, -9.92 in-in-out SNCiio in-out ActLoopNT-in 2.926 ActLoopCT-out nonTYR APEdihe_aaono APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 12.77 APE8-dihe-out 175.17, 160.57 APE8-rot-none 999.0 APE67-dihe-out -106.6, 0.77 -150.85, -100.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.637 None None None XRAY 2.6 0.212 0.259 A 339 320 14 0 0 6 [[161, 477]] 1.0 8p04 Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 8P08A P49759 148 481 484.0 WAZ:60501 Type1 Inactive DFGin 6.917 13.825 BLAminus -129.66, 178.06 64.59, 93.43 -115.04, 31.69 303.49, 95.34 -73.89, -25.33 in-in in 8.624 Saltbr-in 2.677 HRD-in -76.48, -42.72 69.48, -15.82 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iioo APE10-dihe-na -73.7, -173.61 APE9-dihe-na -62.64, 77.27 APE8-dihe-out -66.74, -40.98 APE8-rot-in 246.46 APE67-dihe-out -59.36, 9.02 163.87, 172.03 APE12-dist-in 12.905 APE11-dist-in 9.203 APE10-dist-out 8.846 APE9-dist-out 9.021 None None None XRAY 2.4 0.211 0.26 A 339 334 0 0 0 0 [[161, 477]] 1.0 8p08 Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 8UWNA P49759 148 482 484.0 XQX:1002 Type1 Inactive DFGin 6.969 14.292 BLAminus -127.28, 178.92 66.55, 91.52 -112.74, 24.76 300.27, 94.07 -77.25, -18.47 in-in in 8.725 Saltbr-in 2.692 HRD-in -67.24, -52.59 80.23, -15.08 in-in-out SNCiio in-out ActLoopNT-in 2.95 ActLoopCT-out nonTYR APEdihe_aaino APEdist_oioo APE10-dihe-na -75.07, 130.75 APE9-dihe-na -78.49, -168.23 APE8-dihe-in -60.11, 132.08 APE8-rot-none 999.0 APE67-dihe-out -60.44, -48.1 -144.72, 138.81 APE12-dist-out 14.6 APE11-dist-in 13.749 APE10-dist-out 10.088 APE9-dist-out 8.851 None SEP341,TPO342 SEP341,TPO342 XRAY 1.8 0.18 0.24 A 360 335 0 0 0 0 [[161, 477]] 1.0 8uwn Homo sapiens CMGC_CLK1_HUMAN CMGC 3.1e-93 318.2 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6KHDB P49759 149 482 484.0 3NG:1000 Type1 Inactive DFGin 6.908 14.076 BLAminus -116.48, -175.0 67.35, 80.01 -102.96, 15.9 292.23, 100.48 -53.02, -40.84 in-in in 8.583 Saltbr-in 2.636 HRD-in -57.21, -57.72 79.07, -3.09 in-in-out SNCiio in-out ActLoopNT-in 2.918 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -136.88, 104.05 APE9-dihe-na 173.26, -145.7 APE8-dihe-in -145.78, 56.63 APE8-rot-in 325.36 APE67-dihe-out -165.57, -36.7 24.99, 58.5 APE12-dist-in 13.582 APE11-dist-in 11.89 APE10-dist-in 6.825 APE9-dist-in 3.747 None None None XRAY 2.7 0.204 0.274 B 484 332 2 0 0 0 [[161, 477]] 1.0 6khd Homo sapiens CMGC_CLK1_HUMAN CMGC 8.2e-93 317.4 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 5J1WC P49759 148 483 484.0 6FB:60505,6FB:60506 Type1,Allosteric Inactive DFGin 7.143 14.286 BLAminus -122.18, 173.27 71.94, 86.76 -106.83, 22.04 296.04, 87.14 -77.19, -12.48 in-in in 8.504 Saltbr-in 2.568 HRD-in -74.28, -51.47 84.87, -18.08 in-in-out SNCiio in-out ActLoopNT-in 2.88 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oioo APE10-dihe-na -128.25, 150.31 APE9-dihe-na -78.45, -169.37 APE8-dihe-in -56.02, 117.75 APE8-rot-in 301.81 APE67-dihe-out -74.26, -11.87 -128.54, 128.96 APE12-dist-out 14.754 APE11-dist-in 12.334 APE10-dist-out 9.21 APE9-dist-out 8.676 None None None XRAY 2.42 0.191 0.228 C 339 314 22 0 0 0 [[161, 477]] 1.0 5j1w Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6KHDA P49759 149 481 484.0 3NG:1000 Type1 Inactive DFGin 6.862 14.485 None -115.36, -74.37 -61.99, 112.36 -110.01, 19.25 292.55, 104.1 -59.59, -27.31 in-in in 8.753 Saltbr-in 2.455 HRD-in -79.61, -40.92 65.39, -11.49 in-in-out SNCiio in-out ActLoopNT-in 2.98 ActLoopCT-out nonTYR APEdihe_aannn APEdist_ioon APE10-dihe-na -162.31, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -85.78, 10.46 999.0, -15.39 APE12-dist-in 11.868 APE11-dist-out 7.043 APE10-dist-out 11.635 APE9-dist-none 999.0 None None None XRAY 2.7 0.204 0.274 A 484 322 11 0 0 2 [[161, 477]] 1.0 6khd Homo sapiens CMGC_CLK1_HUMAN CMGC 8.2e-93 317.4 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6Q8PA P49759 148 482 484.0 HQB:60501 Type1 None DFGin 7.111 14.533 BLAminus -124.47, -177.12 56.99, 94.11 -115.67, 29.05 294.23, 87.9 -80.98, -10.13 in-in in 9.013 Saltbr-in 3.418 HRD-in -77.51, -42.79 69.43, -19.47 in-in-none SNCiin in-none ActLoopNT-in 3.131 ActLoopCT-none nonTYR APEdihe_aanii APEdist_iiin APE10-dihe-na -135.51, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.79 APE8-rot-in 323.11 APE67-dihe-in -68.72, -18.82 -64.59, -40.03 APE12-dist-in 13.204 APE11-dist-in 11.201 APE10-dist-in 7.288 APE9-dist-none 999.0 None None None XRAY 3.0 0.201 0.244 A 339 334 1 0 0 1 [[161, 477]] 1.0 6q8p Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CLK1_HUMAN 6Q8PC P49759 148 483 484.0 HQB:60501 Type1 None DFGin 7.261 13.945 BLAminus -128.5, 178.53 59.41, 97.23 -121.71, 37.79 304.27, 105.41 -86.72, -22.18 in-in in 8.676 Saltbr-in 3.006 HRD-in -68.24, -39.01 69.57, -23.21 in-in-none SNCiin in-none ActLoopNT-in 2.953 ActLoopCT-none nonTYR APEdihe_aanii APEdist_iiin APE10-dihe-na -136.11, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.77 APE8-rot-in 314.52 APE67-dihe-in -61.24, -29.44 -57.39, -46.95 APE12-dist-in 13.763 APE11-dist-in 11.126 APE10-dist-in 7.295 APE9-dist-none 999.0 None None None XRAY 3.0 0.201 0.244 C 339 333 3 0 0 1 [[161, 477]] 1.0 6q8p Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
Q382U0_TRYB2 6Q2AD Q382U0 127 465 465.0 5XH:501 Type1 Active DFGin 5.476 13.788 BLAminus -119.9, -168.35 59.48, 71.83 -95.76, 15.53 257.41, 49.17 -69.28, -32.09 in-in in 8.77 Saltbr-in 2.556 HRD-in -77.83, -52.64 69.75, -5.64 in-in-in SNCiii in-in ActLoopNT-in 2.772 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.39, 176.32 APE9-dihe-na 74.78, 146.92 APE8-dihe-in -63.78, 143.48 APE8-rot-in 298.53 APE67-dihe-in -58.91, -29.46 -58.64, -38.04 APE12-dist-in 10.318 APE11-dist-in 11.699 APE10-dist-in 7.651 APE9-dist-in 3.023 None None None XRAY 2.6 0.268 0.313 D 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AE Q382U0 127 465 465.0 5XH:504 Type1 Active DFGin 5.091 13.063 BLAminus -121.78, -169.06 62.52, 72.68 -96.4, 15.33 297.74, 13.76 -68.04, -32.18 in-in in 8.639 Saltbr-in 2.829 HRD-in -76.83, -49.95 71.59, -7.8 in-in-in SNCiii in-in ActLoopNT-in 3.054 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.17, 173.06 APE9-dihe-na 75.56, 145.89 APE8-dihe-in -62.51, 142.36 APE8-rot-in 293.21 APE67-dihe-in -55.52, -31.54 -58.16, -36.13 APE12-dist-in 10.635 APE11-dist-in 11.984 APE10-dist-in 7.465 APE9-dist-in 3.039 None None None XRAY 2.6 0.268 0.313 E 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AG Q382U0 127 465 465.0 5XH:501 Type1 Active DFGin 5.576 13.106 BLAminus -121.56, -172.32 65.3, 68.19 -94.07, 20.09 303.8, 13.18 -67.3, -31.23 in-in in 8.869 Saltbr-in 2.875 HRD-in -76.86, -53.07 69.99, -8.5 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.65, 172.86 APE9-dihe-na 73.21, 147.32 APE8-dihe-in -64.07, 143.32 APE8-rot-in 299.51 APE67-dihe-in -56.19, -31.74 -58.99, -37.58 APE12-dist-in 10.394 APE11-dist-in 11.506 APE10-dist-in 7.422 APE9-dist-in 3.061 None None None XRAY 2.6 0.268 0.313 G 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AM Q382U0 127 465 465.0 5XH:501 Type1 Active DFGin 5.583 13.26 BLAminus -122.03, -174.12 52.78, 74.93 -90.64, 21.24 302.72, 9.96 -64.44, -28.74 in-in in 8.909 Saltbr-in 2.96 HRD-in -77.14, -50.33 71.06, -8.08 in-in-in SNCiii in-in ActLoopNT-in 3.068 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.19, 174.15 APE9-dihe-na 75.38, 147.9 APE8-dihe-in -64.58, 143.28 APE8-rot-in 295.72 APE67-dihe-in -56.44, -31.75 -57.92, -36.92 APE12-dist-in 10.237 APE11-dist-in 11.494 APE10-dist-in 7.185 APE9-dist-in 3.026 None None None XRAY 2.6 0.268 0.313 M 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AN Q382U0 127 465 465.0 5XH:501 Type1 Active DFGin 5.407 12.992 BLAminus -124.15, -169.82 64.49, 69.46 -95.27, 17.53 299.57, 9.78 -67.21, -30.5 in-in in 8.641 Saltbr-in 2.794 HRD-in -76.8, -51.18 70.82, -7.75 in-in-in SNCiii in-in ActLoopNT-in 2.685 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.16, 174.59 APE9-dihe-na 75.11, 146.41 APE8-dihe-in -63.66, 142.73 APE8-rot-in 302.91 APE67-dihe-in -57.03, -31.59 -59.0, -34.83 APE12-dist-in 10.52 APE11-dist-in 11.754 APE10-dist-in 7.386 APE9-dist-in 3.066 None None None XRAY 2.6 0.268 0.313 N 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AP Q382U0 127 465 465.0 5XH:503 Type1 Active DFGin 4.973 12.998 BLAminus -119.74, -171.17 57.48, 79.35 -91.82, 17.72 294.71, 29.77 -67.55, -32.34 in-in in 8.916 Saltbr-in 2.696 HRD-in -77.24, -50.23 71.33, -8.82 in-in-in SNCiii in-in ActLoopNT-in 3.24 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.12, 173.39 APE9-dihe-na 74.96, 147.22 APE8-dihe-in -63.55, 142.75 APE8-rot-in 299.72 APE67-dihe-in -56.0, -31.74 -59.18, -37.4 APE12-dist-in 10.359 APE11-dist-in 11.615 APE10-dist-in 7.254 APE9-dist-in 3.028 None None None XRAY 2.6 0.268 0.313 P 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AA Q382U0 127 465 465.0 5XH:501 Type1 Inactive DFGin 5.586 13.098 BLAminus -119.0, -171.54 54.11, 74.62 -93.72, 19.87 300.89, 14.65 -66.08, -30.37 in-in in 8.854 Saltbr-in 2.791 HRD-in -77.03, -50.56 71.17, -8.06 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.64, 174.75 APE9-dihe-na 75.26, 147.37 APE8-dihe-in -65.92, 143.03 APE8-rot-out 74.14 APE67-dihe-in -55.49, -31.28 -58.8, -36.72 APE12-dist-in 10.391 APE11-dist-in 11.441 APE10-dist-in 7.268 APE9-dist-in 3.025 None None None XRAY 2.6 0.268 0.313 A 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AB Q382U0 127 465 465.0 5XH:504 Type1 Inactive DFGin 5.2 13.216 BLAminus -122.26, -169.1 61.88, 72.0 -96.55, 15.55 296.86, 11.1 -68.18, -31.87 in-in in 8.775 Saltbr-in 3.088 HRD-in -76.88, -50.01 71.06, -8.09 in-in-out SNCiio in-out ActLoopNT-in 3.044 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.33, 173.18 APE9-dihe-na 75.34, 143.51 APE8-dihe-in -64.84, 144.66 APE8-rot-out 80.25 APE67-dihe-in -55.28, -33.02 -56.45, -35.89 APE12-dist-in 10.502 APE11-dist-in 12.018 APE10-dist-in 7.312 APE9-dist-in 3.07 None None None XRAY 2.6 0.268 0.313 B 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AC Q382U0 127 465 465.0 5XH:504 Type1 Inactive DFGin 5.201 13.158 BLAminus -125.39, -171.07 59.62, 74.29 -95.85, 16.24 304.87, 9.48 -67.73, -32.34 in-in in 8.778 Saltbr-in 2.84 HRD-in -76.59, -49.44 71.53, -6.33 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.5, 171.75 APE9-dihe-na 75.06, 143.62 APE8-dihe-in -62.63, 144.12 APE8-rot-out 37.89 APE67-dihe-in -55.38, -31.81 -57.03, -35.43 APE12-dist-in 10.464 APE11-dist-in 11.94 APE10-dist-in 7.226 APE9-dist-in 2.991 None None None XRAY 2.6 0.268 0.313 C 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AF Q382U0 127 465 465.0 5XH:504 Type1 Inactive DFGin 5.056 13.16 BLAminus -122.68, -169.75 60.12, 71.93 -96.6, 14.84 301.3, 12.28 -68.75, -31.62 in-in in 8.751 Saltbr-in 2.896 HRD-in -77.43, -49.63 71.68, -7.89 in-in-out SNCiio in-out ActLoopNT-in 3.077 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.12, 172.1 APE9-dihe-na 74.75, 142.67 APE8-dihe-in -63.4, 143.66 APE8-rot-out 37.46 APE67-dihe-in -55.26, -30.17 -56.65, -36.03 APE12-dist-in 10.478 APE11-dist-in 11.976 APE10-dist-in 7.47 APE9-dist-in 3.002 None None None XRAY 2.6 0.268 0.313 F 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AH Q382U0 127 465 465.0 5XH:503 Type1 Inactive DFGin 5.301 12.969 BLAminus -119.28, -168.95 55.7, 73.66 -95.39, 17.15 309.43, 7.35 -67.18, -32.11 in-in in 8.816 Saltbr-in 2.734 HRD-in -76.83, -51.18 71.75, -9.17 in-in-out SNCiio in-out ActLoopNT-in 2.861 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -121.68, 176.4 APE9-dihe-na 76.23, 143.03 APE8-dihe-in -66.5, 142.66 APE8-rot-out 82.58 APE67-dihe-in -55.95, -26.39 -62.57, -37.5 APE12-dist-in 10.331 APE11-dist-in 11.676 APE10-dist-in 6.977 APE9-dist-in 3.096 None None None XRAY 2.6 0.268 0.313 H 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AI Q382U0 127 465 465.0 5XH:504 Type1 Inactive DFGin 5.338 13.167 BLAminus -123.95, -169.7 61.06, 71.5 -97.59, 15.68 299.06, 12.02 -68.31, -31.48 in-in in 8.603 Saltbr-in 3.032 HRD-in -77.59, -50.58 70.98, -7.46 in-in-out SNCiio in-out ActLoopNT-in 3.004 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.44, 171.47 APE9-dihe-na 75.28, 146.19 APE8-dihe-in -60.08, 142.44 APE8-rot-out 41.76 APE67-dihe-in -54.09, -31.47 -60.2, -34.75 APE12-dist-in 10.549 APE11-dist-in 11.984 APE10-dist-in 7.543 APE9-dist-in 3.003 None None None XRAY 2.6 0.268 0.313 I 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AJ Q382U0 127 465 465.0 5XH:504 Type1 Inactive DFGin 5.097 13.058 BLAminus -122.46, -166.99 62.87, 71.32 -96.61, 15.13 300.0, 9.52 -68.69, -31.3 in-in in 8.594 Saltbr-in 2.779 HRD-in -74.22, -48.82 70.81, -6.67 in-in-out SNCiio in-out ActLoopNT-in 3.19 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -123.88, 173.79 APE9-dihe-na 75.14, 144.51 APE8-dihe-in -64.43, 143.72 APE8-rot-out 36.49 APE67-dihe-in -55.07, -31.92 -56.83, -35.99 APE12-dist-in 10.527 APE11-dist-in 11.943 APE10-dist-in 7.317 APE9-dist-in 3.042 None None None XRAY 2.6 0.268 0.313 J 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AK Q382U0 127 465 465.0 5XH:503 Type1 Inactive DFGin 5.103 13.093 BLAminus -122.02, -166.89 62.21, 72.06 -96.74, 15.47 298.33, 8.85 -68.2, -31.83 in-in in 8.556 Saltbr-in 2.761 HRD-in -77.41, -49.89 71.16, -8.73 in-in-out SNCiio in-out ActLoopNT-in 2.978 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -123.79, 172.74 APE9-dihe-na 74.63, 143.9 APE8-dihe-in -64.46, 143.69 APE8-rot-out 167.18 APE67-dihe-in -54.47, -31.83 -57.73, -35.29 APE12-dist-in 10.555 APE11-dist-in 11.937 APE10-dist-in 7.368 APE9-dist-in 3.019 None None None XRAY 2.6 0.268 0.313 K 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AL Q382U0 127 465 465.0 5XH:503 Type1 Inactive DFGin 5.247 13.368 BLAminus -122.21, -170.28 61.23, 72.83 -97.02, 14.92 300.22, 10.25 -68.16, -32.26 in-in in 9.003 Saltbr-in 2.95 HRD-in -76.72, -49.17 71.44, -6.95 in-in-out SNCiio in-out ActLoopNT-in 3.093 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.35, 171.77 APE9-dihe-na 74.63, 144.65 APE8-dihe-in -64.14, 144.88 APE8-rot-out 47.46 APE67-dihe-in -55.18, -32.42 -57.04, -35.3 APE12-dist-in 10.481 APE11-dist-in 11.938 APE10-dist-in 7.448 APE9-dist-in 3.032 None None None XRAY 2.6 0.268 0.313 L 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AO Q382U0 127 465 465.0 5XH:503 Type1 Inactive DFGin 5.565 13.216 BLAminus -121.28, -170.74 58.31, 73.08 -95.04, 18.11 298.82, 11.51 -65.91, -30.33 in-out in 8.781 Saltbr-out 4.331 HRD-in -77.63, -51.71 71.45, -7.94 out-in-in SNCoii in-in ActLoopNT-in 3.031 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.26, 174.14 APE9-dihe-na 75.9, 145.18 APE8-dihe-in -63.27, 142.33 APE8-rot-in 286.67 APE67-dihe-in -54.38, -29.28 -58.19, -37.84 APE12-dist-in 10.353 APE11-dist-in 11.728 APE10-dist-in 7.336 APE9-dist-in 3.046 None None None XRAY 2.6 0.268 0.313 O 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative

CMGC_CLK1 (Dual specificity protein kinase CLK1)

Total number of chains: 16
Active chains: 6
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 16 100.0% 6Q2AD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
Q382U0_TRYB2 6Q2AD Q382U0 127 465 465.0 5XH:501 Type1 Active DFGin 5.476 13.788 BLAminus -119.9, -168.35 59.48, 71.83 -95.76, 15.53 257.41, 49.17 -69.28, -32.09 in-in in 8.77 Saltbr-in 2.556 HRD-in -77.83, -52.64 69.75, -5.64 in-in-in SNCiii in-in ActLoopNT-in 2.772 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.39, 176.32 APE9-dihe-na 74.78, 146.92 APE8-dihe-in -63.78, 143.48 APE8-rot-in 298.53 APE67-dihe-in -58.91, -29.46 -58.64, -38.04 APE12-dist-in 10.318 APE11-dist-in 11.699 APE10-dist-in 7.651 APE9-dist-in 3.023 None None None XRAY 2.6 0.268 0.313 D 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AE Q382U0 127 465 465.0 5XH:504 Type1 Active DFGin 5.091 13.063 BLAminus -121.78, -169.06 62.52, 72.68 -96.4, 15.33 297.74, 13.76 -68.04, -32.18 in-in in 8.639 Saltbr-in 2.829 HRD-in -76.83, -49.95 71.59, -7.8 in-in-in SNCiii in-in ActLoopNT-in 3.054 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.17, 173.06 APE9-dihe-na 75.56, 145.89 APE8-dihe-in -62.51, 142.36 APE8-rot-in 293.21 APE67-dihe-in -55.52, -31.54 -58.16, -36.13 APE12-dist-in 10.635 APE11-dist-in 11.984 APE10-dist-in 7.465 APE9-dist-in 3.039 None None None XRAY 2.6 0.268 0.313 E 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AG Q382U0 127 465 465.0 5XH:501 Type1 Active DFGin 5.576 13.106 BLAminus -121.56, -172.32 65.3, 68.19 -94.07, 20.09 303.8, 13.18 -67.3, -31.23 in-in in 8.869 Saltbr-in 2.875 HRD-in -76.86, -53.07 69.99, -8.5 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.65, 172.86 APE9-dihe-na 73.21, 147.32 APE8-dihe-in -64.07, 143.32 APE8-rot-in 299.51 APE67-dihe-in -56.19, -31.74 -58.99, -37.58 APE12-dist-in 10.394 APE11-dist-in 11.506 APE10-dist-in 7.422 APE9-dist-in 3.061 None None None XRAY 2.6 0.268 0.313 G 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AM Q382U0 127 465 465.0 5XH:501 Type1 Active DFGin 5.583 13.26 BLAminus -122.03, -174.12 52.78, 74.93 -90.64, 21.24 302.72, 9.96 -64.44, -28.74 in-in in 8.909 Saltbr-in 2.96 HRD-in -77.14, -50.33 71.06, -8.08 in-in-in SNCiii in-in ActLoopNT-in 3.068 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.19, 174.15 APE9-dihe-na 75.38, 147.9 APE8-dihe-in -64.58, 143.28 APE8-rot-in 295.72 APE67-dihe-in -56.44, -31.75 -57.92, -36.92 APE12-dist-in 10.237 APE11-dist-in 11.494 APE10-dist-in 7.185 APE9-dist-in 3.026 None None None XRAY 2.6 0.268 0.313 M 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AN Q382U0 127 465 465.0 5XH:501 Type1 Active DFGin 5.407 12.992 BLAminus -124.15, -169.82 64.49, 69.46 -95.27, 17.53 299.57, 9.78 -67.21, -30.5 in-in in 8.641 Saltbr-in 2.794 HRD-in -76.8, -51.18 70.82, -7.75 in-in-in SNCiii in-in ActLoopNT-in 2.685 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.16, 174.59 APE9-dihe-na 75.11, 146.41 APE8-dihe-in -63.66, 142.73 APE8-rot-in 302.91 APE67-dihe-in -57.03, -31.59 -59.0, -34.83 APE12-dist-in 10.52 APE11-dist-in 11.754 APE10-dist-in 7.386 APE9-dist-in 3.066 None None None XRAY 2.6 0.268 0.313 N 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AP Q382U0 127 465 465.0 5XH:503 Type1 Active DFGin 4.973 12.998 BLAminus -119.74, -171.17 57.48, 79.35 -91.82, 17.72 294.71, 29.77 -67.55, -32.34 in-in in 8.916 Saltbr-in 2.696 HRD-in -77.24, -50.23 71.33, -8.82 in-in-in SNCiii in-in ActLoopNT-in 3.24 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.12, 173.39 APE9-dihe-na 74.96, 147.22 APE8-dihe-in -63.55, 142.75 APE8-rot-in 299.72 APE67-dihe-in -56.0, -31.74 -59.18, -37.4 APE12-dist-in 10.359 APE11-dist-in 11.615 APE10-dist-in 7.254 APE9-dist-in 3.028 None None None XRAY 2.6 0.268 0.313 P 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AA Q382U0 127 465 465.0 5XH:501 Type1 Inactive DFGin 5.586 13.098 BLAminus -119.0, -171.54 54.11, 74.62 -93.72, 19.87 300.89, 14.65 -66.08, -30.37 in-in in 8.854 Saltbr-in 2.791 HRD-in -77.03, -50.56 71.17, -8.06 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.64, 174.75 APE9-dihe-na 75.26, 147.37 APE8-dihe-in -65.92, 143.03 APE8-rot-out 74.14 APE67-dihe-in -55.49, -31.28 -58.8, -36.72 APE12-dist-in 10.391 APE11-dist-in 11.441 APE10-dist-in 7.268 APE9-dist-in 3.025 None None None XRAY 2.6 0.268 0.313 A 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AB Q382U0 127 465 465.0 5XH:504 Type1 Inactive DFGin 5.2 13.216 BLAminus -122.26, -169.1 61.88, 72.0 -96.55, 15.55 296.86, 11.1 -68.18, -31.87 in-in in 8.775 Saltbr-in 3.088 HRD-in -76.88, -50.01 71.06, -8.09 in-in-out SNCiio in-out ActLoopNT-in 3.044 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.33, 173.18 APE9-dihe-na 75.34, 143.51 APE8-dihe-in -64.84, 144.66 APE8-rot-out 80.25 APE67-dihe-in -55.28, -33.02 -56.45, -35.89 APE12-dist-in 10.502 APE11-dist-in 12.018 APE10-dist-in 7.312 APE9-dist-in 3.07 None None None XRAY 2.6 0.268 0.313 B 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AC Q382U0 127 465 465.0 5XH:504 Type1 Inactive DFGin 5.201 13.158 BLAminus -125.39, -171.07 59.62, 74.29 -95.85, 16.24 304.87, 9.48 -67.73, -32.34 in-in in 8.778 Saltbr-in 2.84 HRD-in -76.59, -49.44 71.53, -6.33 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.5, 171.75 APE9-dihe-na 75.06, 143.62 APE8-dihe-in -62.63, 144.12 APE8-rot-out 37.89 APE67-dihe-in -55.38, -31.81 -57.03, -35.43 APE12-dist-in 10.464 APE11-dist-in 11.94 APE10-dist-in 7.226 APE9-dist-in 2.991 None None None XRAY 2.6 0.268 0.313 C 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AF Q382U0 127 465 465.0 5XH:504 Type1 Inactive DFGin 5.056 13.16 BLAminus -122.68, -169.75 60.12, 71.93 -96.6, 14.84 301.3, 12.28 -68.75, -31.62 in-in in 8.751 Saltbr-in 2.896 HRD-in -77.43, -49.63 71.68, -7.89 in-in-out SNCiio in-out ActLoopNT-in 3.077 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.12, 172.1 APE9-dihe-na 74.75, 142.67 APE8-dihe-in -63.4, 143.66 APE8-rot-out 37.46 APE67-dihe-in -55.26, -30.17 -56.65, -36.03 APE12-dist-in 10.478 APE11-dist-in 11.976 APE10-dist-in 7.47 APE9-dist-in 3.002 None None None XRAY 2.6 0.268 0.313 F 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AH Q382U0 127 465 465.0 5XH:503 Type1 Inactive DFGin 5.301 12.969 BLAminus -119.28, -168.95 55.7, 73.66 -95.39, 17.15 309.43, 7.35 -67.18, -32.11 in-in in 8.816 Saltbr-in 2.734 HRD-in -76.83, -51.18 71.75, -9.17 in-in-out SNCiio in-out ActLoopNT-in 2.861 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -121.68, 176.4 APE9-dihe-na 76.23, 143.03 APE8-dihe-in -66.5, 142.66 APE8-rot-out 82.58 APE67-dihe-in -55.95, -26.39 -62.57, -37.5 APE12-dist-in 10.331 APE11-dist-in 11.676 APE10-dist-in 6.977 APE9-dist-in 3.096 None None None XRAY 2.6 0.268 0.313 H 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AI Q382U0 127 465 465.0 5XH:504 Type1 Inactive DFGin 5.338 13.167 BLAminus -123.95, -169.7 61.06, 71.5 -97.59, 15.68 299.06, 12.02 -68.31, -31.48 in-in in 8.603 Saltbr-in 3.032 HRD-in -77.59, -50.58 70.98, -7.46 in-in-out SNCiio in-out ActLoopNT-in 3.004 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.44, 171.47 APE9-dihe-na 75.28, 146.19 APE8-dihe-in -60.08, 142.44 APE8-rot-out 41.76 APE67-dihe-in -54.09, -31.47 -60.2, -34.75 APE12-dist-in 10.549 APE11-dist-in 11.984 APE10-dist-in 7.543 APE9-dist-in 3.003 None None None XRAY 2.6 0.268 0.313 I 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AJ Q382U0 127 465 465.0 5XH:504 Type1 Inactive DFGin 5.097 13.058 BLAminus -122.46, -166.99 62.87, 71.32 -96.61, 15.13 300.0, 9.52 -68.69, -31.3 in-in in 8.594 Saltbr-in 2.779 HRD-in -74.22, -48.82 70.81, -6.67 in-in-out SNCiio in-out ActLoopNT-in 3.19 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -123.88, 173.79 APE9-dihe-na 75.14, 144.51 APE8-dihe-in -64.43, 143.72 APE8-rot-out 36.49 APE67-dihe-in -55.07, -31.92 -56.83, -35.99 APE12-dist-in 10.527 APE11-dist-in 11.943 APE10-dist-in 7.317 APE9-dist-in 3.042 None None None XRAY 2.6 0.268 0.313 J 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AK Q382U0 127 465 465.0 5XH:503 Type1 Inactive DFGin 5.103 13.093 BLAminus -122.02, -166.89 62.21, 72.06 -96.74, 15.47 298.33, 8.85 -68.2, -31.83 in-in in 8.556 Saltbr-in 2.761 HRD-in -77.41, -49.89 71.16, -8.73 in-in-out SNCiio in-out ActLoopNT-in 2.978 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -123.79, 172.74 APE9-dihe-na 74.63, 143.9 APE8-dihe-in -64.46, 143.69 APE8-rot-out 167.18 APE67-dihe-in -54.47, -31.83 -57.73, -35.29 APE12-dist-in 10.555 APE11-dist-in 11.937 APE10-dist-in 7.368 APE9-dist-in 3.019 None None None XRAY 2.6 0.268 0.313 K 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AL Q382U0 127 465 465.0 5XH:503 Type1 Inactive DFGin 5.247 13.368 BLAminus -122.21, -170.28 61.23, 72.83 -97.02, 14.92 300.22, 10.25 -68.16, -32.26 in-in in 9.003 Saltbr-in 2.95 HRD-in -76.72, -49.17 71.44, -6.95 in-in-out SNCiio in-out ActLoopNT-in 3.093 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.35, 171.77 APE9-dihe-na 74.63, 144.65 APE8-dihe-in -64.14, 144.88 APE8-rot-out 47.46 APE67-dihe-in -55.18, -32.42 -57.04, -35.3 APE12-dist-in 10.481 APE11-dist-in 11.938 APE10-dist-in 7.448 APE9-dist-in 3.032 None None None XRAY 2.6 0.268 0.313 L 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative
Q382U0_TRYB2 6Q2AO Q382U0 127 465 465.0 5XH:503 Type1 Inactive DFGin 5.565 13.216 BLAminus -121.28, -170.74 58.31, 73.08 -95.04, 18.11 298.82, 11.51 -65.91, -30.33 in-out in 8.781 Saltbr-out 4.331 HRD-in -77.63, -51.71 71.45, -7.94 out-in-in SNCoii in-in ActLoopNT-in 3.031 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.26, 174.14 APE9-dihe-na 75.9, 145.18 APE8-dihe-in -63.27, 142.33 APE8-rot-in 286.67 APE67-dihe-in -54.38, -29.28 -58.19, -37.84 APE12-dist-in 10.353 APE11-dist-in 11.728 APE10-dist-in 7.336 APE9-dist-in 3.046 None None None XRAY 2.6 0.268 0.313 O 354 339 0 0 0 0 [[129, 439]] 1.0 6q2a Trypanosoma brucei brucei CMGC_CLK1_TRYB2 CMGC 2e-64 223.6 1 301 301 288 289 290 292 294 158 173 177 252 254 253 255 325 313 308 307 306 305 304 303 302 210 Protein kinase, putative