Ligand: 5XH

Total number of chains: 1
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 1 5FEQA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR EGFR EGFR_HUMAN 5FEQA 3.4 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 697 - 1017 5 None T790M Epidermal growth factor receptor

Ligand: 5XH

Total number of chains: 17
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 17 6Q2AA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR EGFR EGFR_HUMAN 5FEQA 3.4 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 697 - 1017 5 None T790M Epidermal growth factor receptor Homo sapiens
CMGC CLK1 Q382U0_TRYB2 6Q2AA 2.6 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AB 2.6 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AC 2.6 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AD 2.6 Active DFGin‑BLAminus in-in in-in 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AE 2.6 Active DFGin‑BLAminus in-in in-in 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AF 2.6 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AG 2.6 Active DFGin‑BLAminus in-in in-in 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AH 2.6 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AI 2.6 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AJ 2.6 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AK 2.6 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AL 2.6 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AM 2.6 Active DFGin‑BLAminus in-in in-in 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AN 2.6 Active DFGin‑BLAminus in-in in-in 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AO 2.6 Inactive DFGin‑BLAminus in-out in-in 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AP 2.6 Active DFGin‑BLAminus in-in in-in 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei

Ligand: 5XH

Total number of chains: 16
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 16 6Q2AA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CLK1 Q382U0_TRYB2 6Q2AA 2.6 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AB 2.6 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AC 2.6 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AD 2.6 Active DFGin‑BLAminus in-in in-in 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AE 2.6 Active DFGin‑BLAminus in-in in-in 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AF 2.6 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AG 2.6 Active DFGin‑BLAminus in-in in-in 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AH 2.6 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AI 2.6 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AJ 2.6 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AK 2.6 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AL 2.6 Inactive DFGin‑BLAminus in-in in-out 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AM 2.6 Active DFGin‑BLAminus in-in in-in 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AN 2.6 Active DFGin‑BLAminus in-in in-in 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AO 2.6 Inactive DFGin‑BLAminus in-out in-in 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei
CMGC CLK1 Q382U0_TRYB2 6Q2AP 2.6 Active DFGin‑BLAminus in-in in-in 5XH Type1 127 - 465 0 None None Protein kinase, putative Trypanosoma brucei brucei