AGC_ROCK2 (Rho-associated protein kinase 2)

Total number of chains: 87
Active chains: 4
Uniprot: ROCK2_HUMAN
Kinase Domain Residues: 92 - 354
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 54 62.1% AF-O75116-K1A
DFGin ABAminus 24 27.6% 8X92A
DFGout BBAminus 6 6.9% 9JCUA
DFGout None 2 2.3% 9JCUB
DFGin None 1 1.1% 5U7RD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-O75116-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 84 - 362 0 None None Rho-associated protein kinase 2
AF-O75116-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 84 - 362 0 None None Rho-associated protein kinase 2
8X8XA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YDW Type1 32 - 417 0 None None Rho-associated protein kinase 2
6ED6A 2.86 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii J0P Type1 27 - 415 0 None None Rho-associated protein kinase 2
6P5MC 2.65 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 18 - 417 0 None F270Y Rho-associated protein kinase 2
6P5MD 2.65 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 18 - 417 0 None F270Y Rho-associated protein kinase 2
5U7QA 3.15 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 25 - 417 0 None None Rho-associated protein kinase 2
5U7QB 3.15 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaooi APEdist_oioo No_ligand No_ligand 28 - 417 0 None None Rho-associated protein kinase 2
5U7QC 3.15 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 23 - 417 0 None None Rho-associated protein kinase 2
5U7QD 3.15 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioo APEdist_iiio No_ligand No_ligand 27 - 417 0 None None Rho-associated protein kinase 2
5U7RA 3.33 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 81G Type1 25 - 417 0 None None Rho-associated protein kinase 2
5U7RC 3.33 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oiio 81G Type1 25 - 417 0 None None Rho-associated protein kinase 2
6P5PA 3.3 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii O1V Type1 27 - 417 0 None F270Y Rho-associated protein kinase 2
6P5PB 3.3 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaooo APEdist_nnio O1V Type1 27 - 417 0 None F270Y Rho-associated protein kinase 2
6P5PC 3.3 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii O1V Type1 28 - 416 0 None F270Y Rho-associated protein kinase 2
6P5PD 3.3 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio O1V Type1 26 - 416 0 None F270Y Rho-associated protein kinase 2
8X8YB 3.2 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iiio YEA Type1 29 - 417 0 None None Rho-associated protein kinase 2
8X8ZA 2.7 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YEI Type1 31 - 416 0 None None Rho-associated protein kinase 2
8X8ZB 2.7 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiio YEI Type1 29 - 417 0 None None Rho-associated protein kinase 2
8X92A 2.2 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YEW Type1 29 - 416 0 None None Rho-associated protein kinase 2
8X92B 2.2 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_noio YEW Type1 29 - 417 0 None None Rho-associated protein kinase 2
4WOTA 2.93 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo 3SG Type1 22 - 417 0 None None Rho-associated protein kinase 2
4WOTB 2.93 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3SG Type1 22 - 417 0 None None Rho-associated protein kinase 2
4WOTC 2.93 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3SG Type1 22 - 417 0 None None Rho-associated protein kinase 2
4WOTD 2.93 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nooo 3SG Type1 23 - 417 0 None None Rho-associated protein kinase 2
9HFPA 2.92 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1IUI Type1 23 - 417 0 None None Rho-associated protein kinase 2
4L6QA 2.79 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 1WU Type1 27 - 417 0 None None Rho-associated protein kinase 2
4L6QB 2.79 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 1WU Type1 27 - 417 0 None None Rho-associated protein kinase 2
5U7RB 3.33 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 81G Type1 25 - 417 0 None None Rho-associated protein kinase 2
6P5MA 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iiio O1S Type1 18 - 417 0 None F270Y Rho-associated protein kinase 2
6P5MB 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oiio O1S Type1 18 - 417 0 None F270Y Rho-associated protein kinase 2
8X8XB 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oiio YDW Type1 29 - 417 0 None None Rho-associated protein kinase 2
8X8YA 3.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii YEA Type1 31 - 417 0 None None Rho-associated protein kinase 2
7JOVA 2.586 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn VFS Type1 25 - 417 0 None None Rho-associated protein kinase 2
7JOVC 2.586 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_onno VFS Type1 23 - 417 0 None None Rho-associated protein kinase 2
7JOVF 2.586 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii VFS Type1 25 - 417 0 None None Rho-associated protein kinase 2
7JOVG 2.586 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_innn VFS Type1 23 - 417 0 None None Rho-associated protein kinase 2
7JOVH 2.586 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii VFS Type1 25 - 417 0 None None Rho-associated protein kinase 2
7JNTA 2.214 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn VFA Type1 25 - 417 0 None None Rho-associated protein kinase 2
7JNTC 2.214 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno VFA Type1 23 - 417 0 None None Rho-associated protein kinase 2
7JNTF 2.214 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii VFA Type1 25 - 417 0 None None Rho-associated protein kinase 2
7JNTG 2.214 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_innn VFA Type1 23 - 417 0 None None Rho-associated protein kinase 2
7JNTH 2.214 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii VFA Type1 25 - 417 0 None None Rho-associated protein kinase 2
7P6NA 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_niio 5YS Type1 24 - 417 0 None None Rho-associated protein kinase 2
7P6NB 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YS Type1 25 - 417 0 None None Rho-associated protein kinase 2
7P6ND 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio 5YS Type1 25 - 417 0 None None Rho-associated protein kinase 2
7P6NF 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio 5YS Type1 25 - 417 0 None None Rho-associated protein kinase 2
7P6NG 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YS Type1 25 - 417 0 None None Rho-associated protein kinase 2
7P6OA 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi 5YK Type1 24 - 417 0 None None Rho-associated protein kinase 2
7P6OB 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YK Type1 25 - 417 0 None None Rho-associated protein kinase 2
7P6OD 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_inii 5YK Type1 25 - 417 0 None None Rho-associated protein kinase 2
7P6OE 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YK Type1 25 - 417 0 None None Rho-associated protein kinase 2
7P6OF 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5YK Type1 25 - 417 0 None None Rho-associated protein kinase 2
7P6PA 2.82 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_onoo 5YV Type1 24 - 417 0 None None Rho-associated protein kinase 2
7P6PB 2.82 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YV Type1 24 - 417 0 None None Rho-associated protein kinase 2
7P6PC 2.82 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YV Type1 24 - 417 0 None None Rho-associated protein kinase 2
7P6PD 2.82 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5YV Type1 24 - 417 0 None None Rho-associated protein kinase 2
7P6QA 2.89 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YO Type1 24 - 417 0 None None Rho-associated protein kinase 2
7P6QB 2.89 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YO Type1 24 - 417 0 None None Rho-associated protein kinase 2
7P6QC 2.89 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnio 5YO Type1 24 - 417 0 None None Rho-associated protein kinase 2
7P6QD 2.89 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5YO Type1 24 - 417 0 None None Rho-associated protein kinase 2
9EP8A 2.63 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo A1H6L Type1 22 - 417 0 None None Rho-associated protein kinase 2
9EP8B 2.63 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn A1H6L Type1 24 - 417 0 None None Rho-associated protein kinase 2
9EP8C 2.63 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn A1H6L Type1 24 - 417 0 None None Rho-associated protein kinase 2
9EP8D 2.63 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo A1H6L Type1 22 - 417 0 None None Rho-associated protein kinase 2
7P6OG 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YK Type1.5_Front 25 - 417 0 None None Rho-associated protein kinase 2
6ED6B 2.86 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnno J0P Type1.5_Front 28 - 416 0 None None Rho-associated protein kinase 2
5U7RD 3.33 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_onno 81G Type1 25 - 417 0 None None Rho-associated protein kinase 2
9JCUA 3.02 Inactive DFGout‑BBAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiio No_ligand No_ligand 27 - 417 0 None None Rho-associated protein kinase 2
9JCUC 3.02 Inactive DFGout‑BBAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 27 - 417 0 None None Rho-associated protein kinase 2
8GDSA 2.71 Inactive DFGout‑BBAminus out-out in-out nonTYR APEdihe_aaiii APEdist_nooo Z8O Type1 24 - 417 0 None None Rho-associated protein kinase 2
8GDSB 2.71 Inactive DFGout‑BBAminus out-none in-out nonTYR APEdihe_aaiii APEdist_nooo Z8O Type1 24 - 417 0 None None Rho-associated protein kinase 2
8GDSC 2.71 Inactive DFGout‑BBAminus out-none in-out nonTYR APEdihe_aaioi APEdist_nnno Z8O Type1 24 - 417 0 None None Rho-associated protein kinase 2
8GDSD 2.71 Inactive DFGout‑BBAminus out-none in-none nonTYR APEdihe_aaiii APEdist_nnii Z8O Type1.5_Front 24 - 417 0 None None Rho-associated protein kinase 2
9JCUB 3.02 Inactive DFGout‑None out-out in-out nonTYR APEdihe_aaioi APEdist_iooi No_ligand No_ligand 27 - 417 0 None None Rho-associated protein kinase 2
9JCUD 3.02 Inactive DFGout‑None out-out in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 27 - 417 0 None None Rho-associated protein kinase 2
7JOVB 2.586 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn VFS Type1 23 - 417 0 None None Rho-associated protein kinase 2
7JOVD 2.586 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn VFS Type1 25 - 417 0 None None Rho-associated protein kinase 2
7JOVE 2.586 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_innn VFS Type1 23 - 417 0 None None Rho-associated protein kinase 2
7JNTB 2.214 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn VFA Type1 23 - 417 0 None None Rho-associated protein kinase 2
7JNTD 2.214 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn VFA Type1 25 - 417 0 None None Rho-associated protein kinase 2
7JNTE 2.214 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn VFA Type1 23 - 417 0 None None Rho-associated protein kinase 2
7P6NC 3.0 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn 5YS Type1 23 - 417 0 None None Rho-associated protein kinase 2
7P6NE 3.0 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn 5YS Type1 23 - 417 0 None None Rho-associated protein kinase 2
7P6NH 3.0 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn 5YS Type1 25 - 417 0 None None Rho-associated protein kinase 2
7P6OC 2.75 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn 5YK Type1.5_Front 22 - 417 0 None None Rho-associated protein kinase 2
7P6OH 2.75 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn 5YK Type1.5_Front 24 - 417 0 None None Rho-associated protein kinase 2

AGC_ROCK2 (Rho-associated protein kinase 2)

Total number of chains: 90
Active chains: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 55 61.1% AF-O75116-K1A
DFGin ABAminus 26 28.9% 8X92A
DFGout BBAminus 6 6.7% 9JCUA
DFGout None 2 2.2% 9JCUB
DFGin None 1 1.1% 5U7RD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
ROCK2_BOVIN 2F2UA 2.4 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii M77 Type1 27 - 417 0 None None Rho-associated protein kinase 2 Bos taurus
ROCK2_BOVIN 2H9VA 3.1 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii Y27 Type1 25 - 417 0 None None Rho-associated protein kinase 2 Bos taurus
ROCK2_BOVIN 2F2UB 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oioo M77 Type1 27 - 417 0 None None Rho-associated protein kinase 2 Bos taurus
ROCK2_HUMAN AF-O75116-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 84 - 362 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN AF-O75116-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 84 - 362 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 8X8XA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YDW Type1 32 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 6ED6A 2.86 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii J0P Type1 27 - 415 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 6P5MC 2.65 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 18 - 417 0 None F270Y Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 6P5MD 2.65 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 18 - 417 0 None F270Y Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 5U7QA 3.15 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 5U7QB 3.15 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaooi APEdist_oioo No_ligand No_ligand 28 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 5U7QC 3.15 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 23 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 5U7QD 3.15 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioo APEdist_iiio No_ligand No_ligand 27 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 5U7RA 3.33 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 81G Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 5U7RC 3.33 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oiio 81G Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 6P5PA 3.3 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii O1V Type1 27 - 417 0 None F270Y Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 6P5PB 3.3 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaooo APEdist_nnio O1V Type1 27 - 417 0 None F270Y Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 6P5PC 3.3 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii O1V Type1 28 - 416 0 None F270Y Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 6P5PD 3.3 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio O1V Type1 26 - 416 0 None F270Y Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 8X8YB 3.2 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iiio YEA Type1 29 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 8X8ZA 2.7 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YEI Type1 31 - 416 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 8X8ZB 2.7 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiio YEI Type1 29 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 8X92A 2.2 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YEW Type1 29 - 416 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 8X92B 2.2 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_noio YEW Type1 29 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 4WOTA 2.93 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo 3SG Type1 22 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 4WOTB 2.93 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3SG Type1 22 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 4WOTC 2.93 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3SG Type1 22 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 4WOTD 2.93 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nooo 3SG Type1 23 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 9HFPA 2.92 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1IUI Type1 23 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 4L6QA 2.79 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 1WU Type1 27 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 4L6QB 2.79 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 1WU Type1 27 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 5U7RB 3.33 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 81G Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 6P5MA 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iiio O1S Type1 18 - 417 0 None F270Y Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 6P5MB 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oiio O1S Type1 18 - 417 0 None F270Y Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 8X8XB 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oiio YDW Type1 29 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 8X8YA 3.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii YEA Type1 31 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7JOVA 2.586 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn VFS Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7JOVC 2.586 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_onno VFS Type1 23 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7JOVF 2.586 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii VFS Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7JOVG 2.586 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_innn VFS Type1 23 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7JOVH 2.586 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii VFS Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7JNTA 2.214 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn VFA Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7JNTC 2.214 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno VFA Type1 23 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7JNTF 2.214 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii VFA Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7JNTG 2.214 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_innn VFA Type1 23 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7JNTH 2.214 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii VFA Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6NA 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_niio 5YS Type1 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6NB 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YS Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6ND 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio 5YS Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6NF 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio 5YS Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6NG 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YS Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6OA 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi 5YK Type1 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6OB 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YK Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6OD 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_inii 5YK Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6OE 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YK Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6OF 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5YK Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6PA 2.82 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_onoo 5YV Type1 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6PB 2.82 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YV Type1 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6PC 2.82 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YV Type1 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6PD 2.82 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5YV Type1 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6QA 2.89 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YO Type1 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6QB 2.89 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YO Type1 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6QC 2.89 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnio 5YO Type1 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6QD 2.89 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5YO Type1 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 9EP8A 2.63 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo A1H6L Type1 22 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 9EP8B 2.63 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn A1H6L Type1 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 9EP8C 2.63 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn A1H6L Type1 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 9EP8D 2.63 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo A1H6L Type1 22 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6OG 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 5YK Type1.5_Front 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 6ED6B 2.86 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnno J0P Type1.5_Front 28 - 416 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 5U7RD 3.33 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_onno 81G Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 9JCUA 3.02 Inactive DFGout‑BBAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiio No_ligand No_ligand 27 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 9JCUC 3.02 Inactive DFGout‑BBAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 27 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 8GDSA 2.71 Inactive DFGout‑BBAminus out-out in-out nonTYR APEdihe_aaiii APEdist_nooo Z8O Type1 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 8GDSB 2.71 Inactive DFGout‑BBAminus out-none in-out nonTYR APEdihe_aaiii APEdist_nooo Z8O Type1 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 8GDSC 2.71 Inactive DFGout‑BBAminus out-none in-out nonTYR APEdihe_aaioi APEdist_nnno Z8O Type1 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 8GDSD 2.71 Inactive DFGout‑BBAminus out-none in-none nonTYR APEdihe_aaiii APEdist_nnii Z8O Type1.5_Front 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 9JCUB 3.02 Inactive DFGout‑None out-out in-out nonTYR APEdihe_aaioi APEdist_iooi No_ligand No_ligand 27 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 9JCUD 3.02 Inactive DFGout‑None out-out in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 27 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7JOVB 2.586 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn VFS Type1 23 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7JOVD 2.586 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn VFS Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7JOVE 2.586 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_innn VFS Type1 23 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7JNTB 2.214 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn VFA Type1 23 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7JNTD 2.214 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn VFA Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7JNTE 2.214 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn VFA Type1 23 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6NC 3.0 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn 5YS Type1 23 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6NE 3.0 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn 5YS Type1 23 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6NH 3.0 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn 5YS Type1 25 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6OC 2.75 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn 5YK Type1.5_Front 22 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
ROCK2_HUMAN 7P6OH 2.75 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn 5YK Type1.5_Front 24 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens

AGC_ROCK2 (Rho-associated protein kinase 2)

Total number of chains: 3
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 66.7% 2F2UA
DFGin BLAminus 1 33.3% 2F2UB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
ROCK2_BOVIN 2F2UA 2.4 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii M77 Type1 27 - 417 0 None None Rho-associated protein kinase 2 Bos taurus
ROCK2_BOVIN 2H9VA 3.1 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii Y27 Type1 25 - 417 0 None None Rho-associated protein kinase 2 Bos taurus
ROCK2_BOVIN 2F2UB 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oioo M77 Type1 27 - 417 0 None None Rho-associated protein kinase 2 Bos taurus