AGC_ROCK2 (Rho-associated protein kinase 2)

Total number of chains: 87
Active chains: 4
Uniprot: ROCK2_HUMAN
Kinase Domain Residues: 92 - 354
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 54 62.1% AF-O75116-K1A
DFGin ABAminus 24 27.6% 8X92A
DFGout BBAminus 6 6.9% 9JCUA
DFGout None 2 2.3% 9JCUB
DFGin None 1 1.1% 5U7RD

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ROCK2 AF-O75116-K1A O75116 84 362 1388.0 No_ligand No_ligand Active DFGin 5.8685 12.9149 BLAminus -136.99, 177.96 53.48, 73.71 -86.19, 14.62 307.2, 104.5 -65.86, -9.9 in-in in 8.7312 Saltbr-in 2.6513 HRD-in -85.23, -49.89 67.76, 1.46 in-in-in SNCiii in-in ActLoopNT-in 2.9592 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.28, 135.21 APE9-dihe-na 135.69, 171.46 APE8-dihe-in -70.75, 130.03 APE8-rot-in 300.74 APE67-dihe-in -77.08, -19.45 -51.29, -40.8 APE12-dist-in 10.4853 APE11-dist-in 11.5675 APE10-dist-in 5.7555 APE9-dist-in 3.6338 None None None AF2 -1.0 1.0 1.0 A 279.0 279.0 0 29 29 0 [[92, 354]] 1.0 AF-O75116-K1 AGC_ROCK2_HUMAN AGC 6.9e-94 319.7 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 AF-O75116-K3A O75116 84 362 1388.0 No_ligand No_ligand Active DFGin 5.8197 13.4492 BLAminus -136.65, 179.19 54.41, 68.61 -80.36, 13.1 307.71, 103.33 -65.49, -10.01 in-in in 8.6735 Saltbr-in 2.629 HRD-in -85.92, -46.0 66.47, 0.5 in-in-in SNCiii in-in ActLoopNT-in 2.9361 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.35, 142.1 APE9-dihe-na 129.39, 171.44 APE8-dihe-in -69.98, 129.02 APE8-rot-in 286.32 APE67-dihe-in -70.68, -17.36 -43.25, -51.09 APE12-dist-in 10.6353 APE11-dist-in 11.9406 APE10-dist-in 6.0099 APE9-dist-in 3.2627 None None None AF2 -1.0 1.0 1.0 A 279.0 279.0 0 29 29 0 [[92, 354]] 1.0 AF-O75116-K3 AGC_ROCK2_HUMAN AGC 6.9e-94 319.7 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 8X8XA O75116 32 417 1388.0 YDW:501 Type1 Active DFGin 6.3582 13.6185 BLAminus -145.81, -178.89 53.82, 76.54 -97.16, 31.49 303.8, 87.87 -66.69, -28.82 in-in in 8.9565 Saltbr-in 2.6653 HRD-in -74.39, -58.56 77.08, -1.86 in-in-in SNCiii in-in ActLoopNT-in 2.9686 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.16, 162.89 APE9-dihe-na 114.79, -140.41 APE8-dihe-in -127.19, 138.75 APE8-rot-in 307.63 APE67-dihe-in -63.05, -28.14 -61.81, -39.49 APE12-dist-in 10.3965 APE11-dist-in 11.7049 APE10-dist-in 5.8573 APE9-dist-in 3.7996 None None None XRAY 2.6 0.201 0.253 A 391.0 380.0 0 29 29 0 [[92, 354]] 1.0 8x8x AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 6ED6A O75116 27 415 1388.0 J0P:501 Type1 Active DFGin 6.4785 13.3609 BLAminus -145.19, 179.01 60.98, 63.29 -87.07, 23.13 303.43, 107.85 -60.41, -48.86 in-in in 8.5317 Saltbr-in 2.7436 HRD-in -56.44, -54.27 71.45, -18.59 in-in-in SNCiii in-in ActLoopNT-in 3.4387 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.8, 126.02 APE9-dihe-na 153.03, -163.23 APE8-dihe-in -114.06, 130.07 APE8-rot-in 328.57 APE67-dihe-in -55.65, -29.13 -25.97, -72.15 APE12-dist-in 10.492 APE11-dist-in 11.3819 APE10-dist-in 5.5534 APE9-dist-in 3.9599 None None None XRAY 2.86 0.206 0.247 A 415.0 378.0 4 29 29 0 [[92, 354]] 1.0 6ed6 AGC_ROCK2_HUMAN AGC 2.6e-93 317.9 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 6P5MC O75116 18 417 1388.0 No_ligand No_ligand Inactive DFGin 6.2844 13.9214 ABAminus -122.7, -9.78 -139.64, 138.02 -140.63, 30.64 305.79, 99.12 -60.86, -31.72 in-in in 9.232 Saltbr-in 2.9118 HRD-in -79.08, -59.4 80.67, -6.5 in-in-in SNCiii in-in ActLoopNT-in 2.9615 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.73, 160.25 APE9-dihe-na 91.47, 176.97 APE8-dihe-in -75.63, 130.45 APE8-rot-in 321.11 APE67-dihe-in -50.51, -34.84 -49.48, -49.9 APE12-dist-in 9.7395 APE11-dist-in 11.5255 APE10-dist-in 5.4867 APE9-dist-in 3.9004 F270Y None None XRAY 2.65 0.195 0.225 C 405.0 395.0 0 29 29 0 [[92, 354]] 1.0 6p5m AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 6P5MD O75116 18 417 1388.0 No_ligand No_ligand Inactive DFGin 6.2848 13.9358 ABAminus -122.32, -12.13 -136.93, 137.32 -138.61, 32.6 305.2, 99.15 -64.64, -30.48 in-in in 9.2036 Saltbr-in 2.9023 HRD-in -80.83, -60.28 80.37, -5.42 in-in-in SNCiii in-in ActLoopNT-in 2.9724 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.85, 159.37 APE9-dihe-na 92.74, 176.75 APE8-dihe-in -76.16, 130.74 APE8-rot-in 321.06 APE67-dihe-in -51.46, -34.25 -48.82, -49.31 APE12-dist-in 9.4784 APE11-dist-in 11.3216 APE10-dist-in 5.2947 APE9-dist-in 3.9097 F270Y None None XRAY 2.65 0.195 0.225 D 405.0 395.0 0 29 29 0 [[92, 354]] 1.0 6p5m AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 5U7QA O75116 25 417 1388.0 No_ligand No_ligand Inactive DFGin 6.259 13.944 ABAminus -118.38, -30.33 -115.44, 138.21 -136.2, 22.48 302.79, 98.72 -67.44, -9.24 in-in in 9.3453 Saltbr-in 2.8508 HRD-in -71.59, -51.25 68.38, 10.85 in-in-out SNCiio in-out ActLoopNT-in 3.0532 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -145.07, 165.16 APE9-dihe-na 99.44, -174.88 APE8-dihe-in -110.13, 133.98 APE8-rot-out 71.35 APE67-dihe-in -43.56, -39.21 -47.25, -61.0 APE12-dist-in 10.3063 APE11-dist-in 11.5193 APE10-dist-in 5.8232 APE9-dist-in 3.5958 None None None XRAY 3.15 0.206 0.235 A 395.0 388.0 0 29 29 0 [[92, 354]] 1.0 5u7q AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 5U7QB O75116 28 417 1388.0 No_ligand No_ligand Inactive DFGin 6.2579 13.8385 ABAminus -117.94, -31.05 -114.29, 137.07 -135.84, 23.64 304.14, 98.35 -71.27, -7.96 in-in in 9.202 Saltbr-in 2.8042 HRD-in -69.76, -50.21 70.12, 10.28 in-in-out SNCiio in-out ActLoopNT-in 3.0836 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na -101.5, 136.43 APE9-dihe-na -97.06, -173.07 APE8-dihe-out 0.71, 109.2 APE8-rot-out 79.45 APE67-dihe-in -42.62, -39.27 -78.6, -9.02 APE12-dist-out 6.3232 APE11-dist-in 9.744 APE10-dist-out 9.5726 APE9-dist-out 9.45 None None None XRAY 3.15 0.206 0.235 B 395.0 385.0 0 29 29 0 [[92, 354]] 1.0 5u7q AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 5U7QC O75116 23 417 1388.0 No_ligand No_ligand Inactive DFGin 6.24 13.9492 ABAminus -118.61, -31.03 -114.56, 138.0 -135.58, 22.3 302.64, 98.81 -68.71, -8.98 in-in in 9.306 Saltbr-in 2.8457 HRD-in -71.74, -50.43 70.98, 8.22 in-in-out SNCiio in-out ActLoopNT-in 3.0654 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -143.91, 164.09 APE9-dihe-na 99.24, -172.98 APE8-dihe-in -112.36, 135.32 APE8-rot-out 71.33 APE67-dihe-in -43.59, -38.66 -47.45, -62.01 APE12-dist-in 10.3606 APE11-dist-in 11.5839 APE10-dist-in 5.8568 APE9-dist-in 3.5914 None None None XRAY 3.15 0.206 0.235 C 395.0 390.0 0 29 29 0 [[92, 354]] 1.0 5u7q AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 5U7QD O75116 27 417 1388.0 No_ligand No_ligand Inactive DFGin 6.2675 13.8702 ABAminus -117.71, -31.1 -114.96, 137.38 -136.24, 22.53 303.71, 99.02 -69.56, -9.33 in-in in 9.2534 Saltbr-in 2.8169 HRD-in -70.86, -50.66 64.9, 13.18 in-in-out SNCiio in-out ActLoopNT-in 3.0696 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiio APE10-dihe-na 129.84, 128.46 APE9-dihe-na 155.49, 162.77 APE8-dihe-in -98.68, 133.35 APE8-rot-out 69.96 APE67-dihe-out 26.46, -59.82 -69.88, -74.55 APE12-dist-in 10.2594 APE11-dist-in 9.2478 APE10-dist-in 6.5691 APE9-dist-out 7.7537 None None None XRAY 3.15 0.206 0.235 D 395.0 383.0 3 29 26 3 [[92, 354]] 1.0 5u7q AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 5U7RA O75116 25 417 1388.0 81G:500 Type1 Inactive DFGin 6.021 13.3928 ABAminus -124.59, -51.34 -100.7, 98.55 -98.24, 10.15 301.55, 107.52 -53.67, -30.47 in-in in 8.8797 Saltbr-in 2.6738 HRD-in -86.61, -51.16 76.24, -9.42 in-in-out SNCiio in-out ActLoopNT-in 2.8386 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -101.07, 144.01 APE9-dihe-na 118.28, 178.92 APE8-dihe-in -78.19, 127.98 APE8-rot-out 37.97 APE67-dihe-in -75.92, -25.7 -48.83, -32.29 APE12-dist-in 10.0319 APE11-dist-in 11.6475 APE10-dist-in 5.6575 APE9-dist-in 4.1525 None None None XRAY 3.33 0.202 0.241 A 395.0 387.0 0 29 29 0 [[92, 354]] 1.0 5u7r AGC_ROCK2_HUMAN AGC 1.7e-93 318.5 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 5U7RC O75116 25 417 1388.0 81G:500 Type1 Inactive DFGin 5.9386 13.56 ABAminus -130.76, -53.46 -102.99, 94.4 -95.45, 17.91 300.98, 105.74 -67.72, -17.68 in-in in 8.525 Saltbr-in 2.8749 HRD-in -81.89, -48.76 85.63, -53.94 in-in-out SNCiio in-out ActLoopNT-in 3.1423 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiio APE10-dihe-na -119.26, 144.44 APE9-dihe-na -73.26, -103.48 APE8-dihe-in -77.65, 129.34 APE8-rot-out 33.83 APE67-dihe-in -30.2, -56.76 -78.66, -11.76 APE12-dist-out 6.0426 APE11-dist-in 9.4249 APE10-dist-in 7.6671 APE9-dist-out 9.9332 None None None XRAY 3.33 0.202 0.241 C 395.0 387.0 0 29 29 0 [[92, 354]] 1.0 5u7r AGC_ROCK2_HUMAN AGC 1.7e-93 318.5 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 6P5PA O75116 27 417 1388.0 O1V:2500 Type1 Inactive DFGin 6.1 13.7982 ABAminus -140.54, -38.15 -103.07, 135.03 -138.91, 13.89 292.53, 107.02 -62.06, -18.82 in-in in 9.0441 Saltbr-in 2.7049 HRD-in -91.96, -54.28 90.29, -35.29 in-in-out SNCiio in-out ActLoopNT-in 3.0978 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.88, 157.67 APE9-dihe-na 95.31, 171.85 APE8-dihe-in -89.1, 136.7 APE8-rot-out 43.44 APE67-dihe-in -58.47, -37.34 -54.83, -41.99 APE12-dist-in 9.8535 APE11-dist-in 11.647 APE10-dist-in 5.6416 APE9-dist-in 4.5055 F270Y None None XRAY 3.3 0.207 0.236 A 405.0 386.0 0 29 29 0 [[92, 354]] 1.0 6p5p AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 6P5PB O75116 27 417 1388.0 O1V:2500 Type1 Inactive DFGin 6.0895 13.6668 ABAminus -142.64, -37.41 -103.44, 133.69 -139.28, 14.63 293.57, 107.2 -60.04, -21.17 in-in in 8.7166 Saltbr-in 2.7128 HRD-in -86.41, -51.75 93.44, -45.12 in-in-out SNCiio in-out ActLoopNT-in 3.1147 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnio APE10-dihe-na 999.0, 98.93 APE9-dihe-na 96.49, 160.02 APE8-dihe-out -136.03, -48.15 APE8-rot-out 58.37 APE67-dihe-out -95.66, -8.92 -10.89, 163.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.8432 APE9-dist-out 7.7851 F270Y None None XRAY 3.3 0.207 0.236 B 405.0 369.0 11 29 24 5 [[92, 354]] 1.0 6p5p AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 6P5PC O75116 28 416 1388.0 O1V:2500 Type1 Inactive DFGin 6.0585 13.7793 ABAminus -141.44, -37.71 -103.72, 135.03 -139.29, 13.77 292.2, 107.44 -61.16, -19.58 in-in in 9.0196 Saltbr-in 2.5842 HRD-in -89.59, -53.69 91.0, -37.17 in-in-out SNCiio in-out ActLoopNT-in 3.0972 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.85, 160.08 APE9-dihe-na 94.19, 175.02 APE8-dihe-in -83.56, 138.16 APE8-rot-out 27.44 APE67-dihe-in -59.59, -38.55 -52.39, -43.92 APE12-dist-in 9.8679 APE11-dist-in 11.697 APE10-dist-in 5.6986 APE9-dist-in 4.6141 F270Y None None XRAY 3.3 0.207 0.236 C 405.0 375.0 9 29 29 0 [[92, 354]] 1.0 6p5p AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 6P5PD O75116 26 416 1388.0 O1V:2500 Type1 Inactive DFGin 6.0632 13.5384 ABAminus -142.31, -37.19 -102.73, 133.81 -138.95, 14.8 293.03, 107.98 -61.89, -20.52 in-in in 8.7293 Saltbr-in 3.0028 HRD-in -87.78, -50.98 94.3, -44.63 in-in-out SNCiio in-out ActLoopNT-in 3.1052 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na 142.21, 160.44 APE9-dihe-na 98.4, 160.87 APE8-dihe-in -91.67, 134.46 APE8-rot-out 44.39 APE67-dihe-in -35.6, -42.17 -54.98, -42.29 APE12-dist-in 8.5396 APE11-dist-in 10.2333 APE10-dist-in 6.8652 APE9-dist-out 8.0997 F270Y None None XRAY 3.3 0.207 0.236 D 405.0 382.0 4 29 28 1 [[92, 354]] 1.0 6p5p AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 8X8YB O75116 29 417 1388.0 YEA:501 Type1 Inactive DFGin 6.1449 13.0959 ABAminus -143.12, -33.94 -106.09, 93.06 -90.35, 19.08 311.7, 96.3 -43.48, -33.82 in-in in 8.2745 Saltbr-in 2.7029 HRD-out -97.55, 96.59 -73.9, -11.34 in-in-out SNCiio in-out ActLoopNT-in 2.6759 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -120.75, 154.61 APE9-dihe-na -77.81, -131.7 APE8-dihe-in -64.67, 142.4 APE8-rot-in 325.66 APE67-dihe-in -41.68, -27.46 -83.12, -16.83 APE12-dist-in 7.4742 APE11-dist-in 8.0672 APE10-dist-in 6.6236 APE9-dist-out 9.5857 None None None XRAY 3.2 0.185 0.243 B 391.0 381.0 2 29 27 2 [[92, 354]] 1.0 8x8y AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 8X8ZA O75116 31 416 1388.0 YEI:501 Type1 Inactive DFGin 6.2225 13.3215 ABAminus -137.94, -35.4 -107.28, 98.66 -104.78, 35.55 309.08, 94.51 -70.09, -34.82 in-in in 8.6253 Saltbr-in 2.5135 HRD-in -74.7, -54.55 74.9, -7.49 in-in-in SNCiii in-in ActLoopNT-in 2.9733 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.04, 159.96 APE9-dihe-na 107.67, -142.65 APE8-dihe-in -117.59, 137.7 APE8-rot-in 304.03 APE67-dihe-in -63.05, -29.24 -60.27, -42.21 APE12-dist-in 9.9482 APE11-dist-in 11.4541 APE10-dist-in 5.5693 APE9-dist-in 3.9424 None None None XRAY 2.7 0.202 0.255 A 391.0 379.0 0 29 29 0 [[92, 354]] 1.0 8x8z AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 8X8ZB O75116 29 417 1388.0 YEI:501 Type1 Inactive DFGin 6.1982 13.0715 ABAminus -136.69, -32.87 -113.62, 107.48 -108.59, 37.17 307.49, 93.35 -67.13, -33.87 in-in in 8.4703 Saltbr-in 3.2116 HRD-in -75.89, -53.13 77.36, -18.94 in-in-out SNCiio in-out ActLoopNT-in 3.1029 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -120.39, 156.94 APE9-dihe-na -95.08, -124.51 APE8-dihe-in -71.89, 132.74 APE8-rot-in 281.12 APE67-dihe-in -52.91, -35.61 -79.81, -3.34 APE12-dist-out 6.2225 APE11-dist-in 8.1162 APE10-dist-in 6.3964 APE9-dist-out 9.0684 None None None XRAY 2.7 0.202 0.255 B 391.0 376.0 7 29 22 7 [[92, 354]] 1.0 8x8z AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 8X92A O75116 29 416 1388.0 YEW:501 Type1 Inactive DFGin 6.2828 13.5091 ABAminus -130.17, -37.88 -106.77, 98.05 -102.95, 26.89 303.41, 99.6 -63.14, -27.04 in-in in 8.5046 Saltbr-in 2.3441 HRD-in -76.14, -56.17 76.65, -10.0 in-in-in SNCiii in-in ActLoopNT-in 3.0965 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.17, 164.81 APE9-dihe-na 100.98, -149.71 APE8-dihe-in -115.92, 137.43 APE8-rot-in 295.58 APE67-dihe-in -63.22, -26.51 -58.54, -42.75 APE12-dist-in 10.1553 APE11-dist-in 11.5226 APE10-dist-in 5.6808 APE9-dist-in 3.7573 None None None XRAY 2.2 0.209 0.24 A 391.0 384.0 0 29 29 0 [[92, 354]] 1.0 8x92 AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 8X92B O75116 29 417 1388.0 YEW:501 Type1 Inactive DFGin 6.3901 13.3512 ABAminus -130.25, -35.39 -108.15, 104.62 -106.39, 29.3 307.45, 100.77 -61.59, -28.54 in-in in 8.3473 Saltbr-in 2.9402 HRD-in -76.68, -52.79 78.59, -25.26 in-in-out SNCiio in-out ActLoopNT-in 3.0915 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_noio APE10-dihe-na -131.54, -42.51 APE9-dihe-na 102.33, -143.39 APE8-dihe-in -75.11, 133.17 APE8-rot-out 81.17 APE67-dihe-in -53.78, -31.77 -93.71, 6.6 APE12-dist-none 999.0 APE11-dist-out 7.6747 APE10-dist-in 6.5685 APE9-dist-out 9.5363 None None None XRAY 2.2 0.209 0.24 B 391.0 368.0 15 29 19 10 [[92, 354]] 1.0 8x92 AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 4WOTA O75116 22 417 1388.0 3SG:501 Type1 Inactive DFGin 6.1945 13.074 ABAminus -135.17, -10.51 -134.2, 128.83 -131.16, 28.81 310.32, 108.74 -62.4, -34.78 in-in in 8.967 Saltbr-in 2.447 HRD-in -67.9, -48.5 51.03, 22.17 in-in-out SNCiio in-out ActLoopNT-in 2.9899 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 151.53 APE9-dihe-na 148.47, -177.25 APE8-dihe-in -79.02, 124.53 APE8-rot-out 69.87 APE67-dihe-in -33.84, -49.13 -87.01, 2.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.5577 APE9-dist-out 7.9832 None None None XRAY 2.93 0.223 0.268 A 396.0 389.0 3 29 26 3 [[92, 354]] 1.0 4wot AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 4WOTB O75116 22 417 1388.0 3SG:501 Type1 Inactive DFGin 6.2061 13.412 ABAminus -121.15, -29.83 -129.18, 101.54 -100.78, 25.44 307.28, 101.28 -60.27, -29.91 in-in in 9.2394 Saltbr-in 2.5551 HRD-in -73.23, -53.38 48.65, 30.57 in-in-in SNCiii in-in ActLoopNT-in 3.0139 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.19, 136.46 APE9-dihe-na 130.7, 169.23 APE8-dihe-in -78.33, 140.31 APE8-rot-in 315.87 APE67-dihe-in -66.72, -32.79 -54.96, -39.47 APE12-dist-in 10.2698 APE11-dist-in 11.1208 APE10-dist-in 5.4011 APE9-dist-in 3.961 None None None XRAY 2.93 0.223 0.268 B 396.0 394.0 0 29 29 0 [[92, 354]] 1.0 4wot AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 4WOTC O75116 22 417 1388.0 3SG:501 Type1 Inactive DFGin 6.3975 13.1365 ABAminus -155.48, 37.05 -162.57, 126.3 -126.94, 37.81 307.24, 97.39 -72.68, -39.98 in-in in 8.8532 Saltbr-in 2.7026 HRD-in -72.02, -52.38 47.81, 35.39 in-in-in SNCiii in-in ActLoopNT-in 3.0572 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.22, 153.14 APE9-dihe-na 111.79, 170.52 APE8-dihe-in -74.42, 135.59 APE8-rot-in 311.52 APE67-dihe-in -64.13, -31.94 -46.85, -44.87 APE12-dist-in 10.3652 APE11-dist-in 11.1725 APE10-dist-in 5.5084 APE9-dist-in 4.1825 None None None XRAY 2.93 0.223 0.268 C 396.0 392.0 0 29 29 0 [[92, 354]] 1.0 4wot AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 4WOTD O75116 23 417 1388.0 3SG:501 Type1 Inactive DFGin 6.2523 13.2573 ABAminus -118.96, -34.54 -121.89, 101.62 -103.9, 33.36 309.85, 95.26 -70.03, -28.11 in-in in 9.0867 Saltbr-in 2.4432 HRD-in -70.37, -47.18 69.99, 3.47 in-in-out SNCiio in-out ActLoopNT-in 2.9303 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -161.47, 159.03 APE9-dihe-na 169.18, 177.89 APE8-dihe-in -96.13, 131.57 APE8-rot-out 64.42 APE67-dihe-in -46.94, -47.22 -87.02, 3.22 APE12-dist-none 999.0 APE11-dist-out 7.5647 APE10-dist-out 8.7203 APE9-dist-out 7.9469 None None None XRAY 2.93 0.223 0.268 D 396.0 389.0 2 29 27 2 [[92, 354]] 1.0 4wot AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 9HFPA O75116 23 417 1388.0 A1IUI:501 Type1 Inactive DFGin 6.3249 13.4859 ABAminus -116.81, -23.83 -103.61, 131.6 -131.15, 17.95 300.42, 103.4 -50.91, -44.1 in-in in 8.775 Saltbr-in 2.9731 HRD-in -60.74, -61.14 76.47, -4.94 in-in-in SNCiii in-in ActLoopNT-in 3.0445 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.76, 160.47 APE9-dihe-na 106.89, -168.78 APE8-dihe-in -100.64, 133.74 APE8-rot-in 307.74 APE67-dihe-in -64.45, -23.8 -40.67, -47.85 APE12-dist-in 10.2329 APE11-dist-in 11.3544 APE10-dist-in 5.4907 APE9-dist-in 3.677 None None None XRAY 2.92 0.206 0.22 A 396.0 391.0 0 29 29 0 [[92, 354]] 1.0 9hfp AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 4L6QA O75116 27 417 1388.0 1WU:501 Type1 Inactive DFGin 6.3025 13.5702 ABAminus -116.27, -49.25 -107.45, 128.66 -126.56, 33.88 304.03, 88.55 -72.5, -17.13 in-in in 8.8823 Saltbr-in 2.672 HRD-in -73.76, -46.68 73.56, -20.06 in-in-out SNCiio in-out ActLoopNT-in 2.9796 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -127.31, 131.57 APE9-dihe-na 145.53, -153.1 APE8-dihe-in -136.66, 121.88 APE8-rot-out 181.69 APE67-dihe-in -54.43, -25.79 -36.79, -58.64 APE12-dist-in 10.6283 APE11-dist-in 11.4732 APE10-dist-in 5.6957 APE9-dist-in 3.9166 None None None XRAY 2.79 0.224 0.281 A 402.0 388.0 0 29 29 0 [[92, 354]] 1.0 4l6q AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 4L6QB O75116 27 417 1388.0 1WU:501 Type1 Inactive DFGin 6.2412 13.4208 ABAminus -107.91, -62.87 -88.93, 144.15 -141.39, 24.98 298.39, 99.37 -69.99, -11.39 in-out in 8.7899 Saltbr-out 4.2152 HRD-in -77.55, -55.12 77.74, -6.89 out-in-in SNCoii in-in ActLoopNT-in 3.1737 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.98, 112.76 APE9-dihe-na 161.13, -165.93 APE8-dihe-in -114.84, 120.25 APE8-rot-in 312.46 APE67-dihe-in -62.07, -22.46 -26.22, -64.13 APE12-dist-in 10.2175 APE11-dist-in 11.4445 APE10-dist-in 5.753 APE9-dist-in 3.7448 None None None XRAY 2.79 0.224 0.281 B 402.0 388.0 0 29 29 0 [[92, 354]] 1.0 4l6q AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 5U7RB O75116 25 417 1388.0 81G:500 Type1 Inactive DFGin 5.7545 13.641 BLAminus -141.67, 175.83 55.92, 92.76 -111.9, 4.36 301.65, 97.85 -69.51, 58.89 in-in in 8.8502 Saltbr-in 2.5587 HRD-in -72.3, -58.92 77.62, -4.98 in-in-out SNCiio in-out ActLoopNT-in 3.0494 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -76.98, 141.69 APE9-dihe-na 134.81, 151.0 APE8-dihe-in -74.28, 133.5 APE8-rot-out 61.19 APE67-dihe-in -51.66, -36.53 -38.48, -66.38 APE12-dist-in 9.9046 APE11-dist-in 11.8182 APE10-dist-in 5.7763 APE9-dist-in 3.6428 None None None XRAY 3.33 0.202 0.241 B 395.0 387.0 0 29 29 0 [[92, 354]] 1.0 5u7r AGC_ROCK2_HUMAN AGC 1.7e-93 318.5 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 6P5MA O75116 18 417 1388.0 O1S:62500 Type1 Inactive DFGin 6.2632 13.4746 BLAminus -124.02, 171.64 60.38, 93.51 -113.45, 31.35 303.9, 98.44 -64.25, -25.91 in-in in 8.4947 Saltbr-in 2.8343 HRD-in -79.85, -57.22 94.02, -30.37 in-in-out SNCiio in-out ActLoopNT-in 2.9886 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -116.08, 168.2 APE9-dihe-na -93.6, -119.04 APE8-dihe-in -73.92, 129.61 APE8-rot-in 321.09 APE67-dihe-in -55.49, -37.68 -79.71, 0.19 APE12-dist-in 7.8013 APE11-dist-in 9.5024 APE10-dist-in 7.3888 APE9-dist-out 8.9426 F270Y None None XRAY 2.65 0.195 0.225 A 405.0 395.0 0 29 29 0 [[92, 354]] 1.0 6p5m AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 6P5MB O75116 18 417 1388.0 O1S:62500 Type1 Inactive DFGin 6.2513 13.6437 BLAminus -124.65, 169.29 60.65, 93.77 -114.08, 30.09 303.05, 96.36 -58.22, -30.22 in-in in 8.643 Saltbr-in 2.8309 HRD-in -79.09, -57.01 92.03, -28.0 in-in-out SNCiio in-out ActLoopNT-in 2.9838 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiio APE10-dihe-na -109.09, 158.86 APE9-dihe-na -92.72, -122.33 APE8-dihe-in -76.3, 130.79 APE8-rot-out 86.08 APE67-dihe-in -53.57, -38.7 -80.54, 4.1 APE12-dist-out 6.637 APE11-dist-in 9.2605 APE10-dist-in 7.384 APE9-dist-out 9.0942 F270Y None None XRAY 2.65 0.195 0.225 B 405.0 387.0 0 29 29 0 [[92, 354]] 1.0 6p5m AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 8X8XB O75116 29 417 1388.0 YDW:501 Type1 Inactive DFGin 6.4728 13.5414 BLAminus -147.7, 178.94 53.55, 85.93 -102.48, 38.62 301.82, 90.81 -61.05, -30.52 in-in in 8.7733 Saltbr-in 2.8799 HRD-in -76.73, -58.01 80.73, -14.45 in-in-out SNCiio in-out ActLoopNT-in 3.0423 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiio APE10-dihe-na -122.98, 163.07 APE9-dihe-na -99.31, -128.88 APE8-dihe-in -61.96, 135.88 APE8-rot-out 70.76 APE67-dihe-in -50.09, -36.4 -79.46, -6.55 APE12-dist-out 6.7308 APE11-dist-in 8.3441 APE10-dist-in 6.7439 APE9-dist-out 9.3326 None None None XRAY 2.6 0.201 0.253 B 391.0 374.0 9 29 20 9 [[92, 354]] 1.0 8x8x AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 8X8YA O75116 31 417 1388.0 YEA:501 Type1 Inactive DFGin 6.1307 13.1234 BLAminus -148.21, -169.14 44.6, 71.48 -91.3, 16.21 306.78, 89.53 -42.97, -27.25 in-in in 8.4017 Saltbr-in 2.8276 HRD-out -91.42, 96.9 -78.93, 1.22 in-in-out SNCiio in-out ActLoopNT-in 2.9643 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.94, 153.9 APE9-dihe-na 130.12, -144.45 APE8-dihe-in -138.71, 148.43 APE8-rot-out 78.56 APE67-dihe-in -57.28, -22.24 -69.59, -38.91 APE12-dist-in 10.8544 APE11-dist-in 11.8292 APE10-dist-in 5.9972 APE9-dist-in 4.0519 None None None XRAY 3.2 0.185 0.243 A 391.0 378.0 0 29 29 0 [[92, 354]] 1.0 8x8y AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7JOVA O75116 25 417 1388.0 VFS:502 Type1 Inactive DFGin 6.2465 13.2928 BLAminus -141.83, 172.55 62.54, 72.12 -93.6, 17.75 301.11, 105.91 -60.63, -17.81 in-in in 8.505 Saltbr-in 2.6448 HRD-in -61.37, -48.09 70.0, -5.6 in-in-out SNCiio in-out ActLoopNT-in 3.1039 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.41 APE8-rot-out 35.63 APE67-dihe-in -72.9, -30.33 -60.06, -49.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 A 395.0 377.0 12 29 23 6 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7JOVC O75116 23 417 1388.0 VFS:501 Type1 Inactive DFGin 6.2684 13.2283 BLAminus -142.15, 173.25 63.2, 71.86 -94.04, 16.61 301.5, 104.97 -62.04, -13.94 in-in in 8.3763 Saltbr-in 2.7548 HRD-in -63.91, -46.28 70.58, -6.77 in-in-out SNCiio in-out ActLoopNT-in 3.102 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_onno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -148.71 APE8-dihe-in -13.99, 103.33 APE8-rot-out 49.66 APE67-dihe-in -50.5, -34.0 -98.95, 10.78 APE12-dist-out 6.1146 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.4434 None None None XRAY 2.586 0.185 0.217 C 395.0 389.0 3 29 27 2 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7JOVF O75116 25 417 1388.0 VFS:502 Type1 Inactive DFGin 6.2536 13.3298 BLAminus -142.21, 173.17 67.59, 68.13 -95.04, 16.84 301.9, 107.53 -61.95, -15.75 in-in in 8.5726 Saltbr-in 2.7159 HRD-in -62.26, -47.83 69.9, -5.26 in-in-out SNCiio in-out ActLoopNT-in 3.0981 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -82.91, 164.49 APE9-dihe-na 87.67, 168.25 APE8-dihe-in -79.05, 142.33 APE8-rot-out 46.7 APE67-dihe-in -72.13, -29.81 -50.42, -43.74 APE12-dist-in 8.1458 APE11-dist-in 11.7085 APE10-dist-in 5.7795 APE9-dist-in 4.2858 None None None XRAY 2.586 0.185 0.217 F 395.0 385.0 4 29 29 0 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7JOVG O75116 23 417 1388.0 VFS:501 Type1 Inactive DFGin 6.268 13.2068 BLAminus -141.3, 172.73 62.62, 71.55 -93.79, 17.44 301.31, 106.61 -60.9, -17.27 in-in in 8.3572 Saltbr-in 2.6194 HRD-in -63.54, -47.24 68.64, -6.0 in-in-out SNCiio in-out ActLoopNT-in 3.1285 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_innn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.83 APE8-rot-out 39.24 APE67-dihe-in -74.92, -26.36 -51.82, -46.1 APE12-dist-in 10.1264 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 G 395.0 388.0 3 29 26 3 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7JOVH O75116 25 417 1388.0 VFS:501 Type1 Inactive DFGin 6.2783 13.2446 BLAminus -141.88, 173.26 61.58, 72.11 -93.64, 17.43 301.68, 105.86 -61.63, -15.37 in-in in 8.4613 Saltbr-in 2.6636 HRD-in -62.24, -47.57 69.31, -6.43 in-in-out SNCiio in-out ActLoopNT-in 3.1108 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -73.76, 175.86 APE9-dihe-na 74.79, 179.62 APE8-dihe-in -84.69, 144.58 APE8-rot-out 45.29 APE67-dihe-in -73.44, -28.15 -53.28, -43.42 APE12-dist-in 8.553 APE11-dist-in 11.9866 APE10-dist-in 5.9693 APE9-dist-in 4.3451 None None None XRAY 2.586 0.185 0.217 H 395.0 386.0 4 29 29 0 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7JNTA O75116 25 417 1388.0 VFA:501 Type1 Inactive DFGin 6.175 13.12 BLAminus -142.97, 170.43 61.47, 81.89 -100.92, 25.83 302.43, 103.03 -66.54, -18.35 in-in in 8.58 Saltbr-in 2.7108 HRD-in -62.06, -54.07 74.24, -0.78 in-in-out SNCiio in-out ActLoopNT-in 2.9951 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 115.83 APE8-rot-out 43.33 APE67-dihe-in -64.51, -30.07 -62.81, -50.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 A 399.0 377.0 12 29 23 6 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7JNTC O75116 23 417 1388.0 VFA:501 Type1 Inactive DFGin 6.1756 13.0954 BLAminus -142.99, 169.96 64.19, 75.58 -96.75, 25.55 303.7, 101.46 -67.43, -15.16 in-in in 8.5271 Saltbr-in 2.7058 HRD-in -63.08, -53.72 74.17, -1.22 in-in-out SNCiio in-out ActLoopNT-in 2.9779 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -147.91 APE8-dihe-in -58.47, 131.63 APE8-rot-out 67.86 APE67-dihe-in -44.06, -35.52 -96.11, -4.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.7755 None None None XRAY 2.214 0.211 0.249 C 399.0 386.0 6 29 25 4 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7JNTF O75116 25 417 1388.0 VFA:501 Type1 Inactive DFGin 6.159 13.2166 BLAminus -143.26, 173.18 61.07, 77.1 -97.98, 23.74 303.85, 102.16 -65.15, -17.6 in-in in 8.72 Saltbr-in 2.6872 HRD-in -62.56, -52.92 74.79, -2.1 in-in-out SNCiio in-out ActLoopNT-in 2.9914 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -119.34, 164.51 APE9-dihe-na 111.51, 140.88 APE8-dihe-in -67.31, 148.28 APE8-rot-out 57.04 APE67-dihe-in -67.65, -28.23 -51.9, -44.63 APE12-dist-in 9.7352 APE11-dist-in 11.3689 APE10-dist-in 5.7501 APE9-dist-in 3.9764 None None None XRAY 2.214 0.211 0.249 F 399.0 385.0 4 29 29 0 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7JNTG O75116 23 417 1388.0 VFA:501 Type1 Inactive DFGin 6.1965 13.0703 BLAminus -143.43, 168.41 64.09, 78.4 -99.56, 26.13 303.07, 104.77 -66.2, -17.95 in-in in 8.6534 Saltbr-in 2.6843 HRD-in -63.78, -53.8 74.38, -0.92 in-in-out SNCiio in-out ActLoopNT-in 2.9912 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_innn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 149.13 APE8-rot-out 59.5 APE67-dihe-in -66.38, -28.99 -52.8, -45.16 APE12-dist-in 10.9468 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 G 399.0 388.0 3 29 26 3 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7JNTH O75116 25 417 1388.0 VFA:501 Type1 Inactive DFGin 6.1825 13.1034 BLAminus -143.87, 172.69 61.19, 80.41 -100.34, 25.34 303.5, 101.89 -66.59, -15.9 in-in in 8.6709 Saltbr-in 2.6568 HRD-in -62.35, -53.45 73.79, -2.54 in-in-out SNCiio in-out ActLoopNT-in 3.0057 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.01, 163.73 APE9-dihe-na 113.76, 141.54 APE8-dihe-in -65.64, 151.02 APE8-rot-out 56.73 APE67-dihe-in -67.63, -28.53 -53.68, -45.01 APE12-dist-in 9.8761 APE11-dist-in 11.5797 APE10-dist-in 5.8796 APE9-dist-in 4.0731 None None None XRAY 2.214 0.211 0.249 H 399.0 386.0 4 29 29 0 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6NA O75116 24 417 1388.0 5YS:501 Type1 Inactive DFGin 5.9603 12.8924 BLAminus -147.52, 173.21 55.09, 95.25 -112.31, 21.69 306.93, 92.98 -47.43, -30.39 in-in in 8.6076 Saltbr-in 2.8602 HRD-in -68.21, -48.5 74.44, -76.91 in-in-out SNCiio in-out ActLoopNT-in 3.1915 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_niio APE10-dihe-na -137.17, 134.7 APE9-dihe-na 66.08, 179.98 APE8-dihe-in -79.2, 152.03 APE8-rot-out 39.36 APE67-dihe-in -55.24, -42.06 -64.41, -46.65 APE12-dist-none 999.0 APE11-dist-in 9.5364 APE10-dist-in 6.7557 APE9-dist-out 7.0612 None None None XRAY 3.0 0.186 0.288 A 399.0 384.0 6 29 26 3 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6NB O75116 25 417 1388.0 5YS:501 Type1 Inactive DFGin 5.9177 12.9079 BLAminus -147.26, 173.64 54.74, 95.37 -112.38, 21.14 305.76, 93.69 -46.34, -30.83 in-in in 8.6582 Saltbr-in 2.8521 HRD-in -68.62, -48.31 74.92, -77.15 in-in-out SNCiio in-out ActLoopNT-in 3.1963 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 152.85 APE8-rot-out 38.72 APE67-dihe-in -58.22, -39.82 -64.87, -46.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 B 399.0 385.0 8 29 25 4 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6ND O75116 25 417 1388.0 5YS:501 Type1 Inactive DFGin 5.9112 12.8869 BLAminus -147.57, 174.08 54.32, 95.38 -112.83, 20.77 305.2, 94.02 -46.7, -30.3 in-in in 8.6465 Saltbr-in 2.8456 HRD-in -68.81, -47.96 75.21, -77.34 in-in-out SNCiio in-out ActLoopNT-in 3.1908 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -138.24, 168.24 APE9-dihe-na 66.25, -164.28 APE8-dihe-in -79.15, 151.39 APE8-rot-out 38.92 APE67-dihe-in -57.2, -39.94 -65.63, -47.15 APE12-dist-in 12.8721 APE11-dist-in 11.2239 APE10-dist-in 6.1189 APE9-dist-out 7.0124 None None None XRAY 3.0 0.186 0.288 D 399.0 385.0 4 29 29 0 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6NF O75116 25 417 1388.0 5YS:501 Type1 Inactive DFGin 5.9261 12.9235 BLAminus -146.77, 174.8 54.66, 94.69 -112.86, 21.29 304.94, 93.72 -46.03, -30.46 in-in in 8.6588 Saltbr-in 2.8458 HRD-in -68.6, -48.35 74.88, -77.16 in-in-out SNCiio in-out ActLoopNT-in 3.1986 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -139.14, 168.92 APE9-dihe-na 66.99, -163.85 APE8-dihe-in -78.8, 151.2 APE8-rot-out 38.36 APE67-dihe-in -57.1, -40.42 -65.28, -46.28 APE12-dist-in 11.5866 APE11-dist-in 11.279 APE10-dist-in 6.1627 APE9-dist-out 7.029 None None None XRAY 3.0 0.186 0.288 F 399.0 384.0 5 29 29 0 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6NG O75116 25 417 1388.0 5YS:501 Type1 Inactive DFGin 5.9599 12.8721 BLAminus -147.02, 173.65 54.4, 95.21 -112.65, 21.16 306.2, 93.32 -46.85, -30.81 in-in in 8.6136 Saltbr-in 2.8449 HRD-in -68.3, -48.58 74.65, -77.07 in-in-out SNCiio in-out ActLoopNT-in 3.1927 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 153.91 APE8-rot-out 38.81 APE67-dihe-in -55.86, -41.48 -64.55, -46.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 G 399.0 385.0 4 29 25 4 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6OA O75116 24 417 1388.0 5YK:501 Type1 Inactive DFGin 6.0154 13.121 BLAminus -129.99, 173.74 63.69, 84.38 -107.33, 35.64 304.65, 101.12 -72.03, -45.78 in-in in 8.633 Saltbr-in 2.7576 HRD-in -67.26, -41.63 68.26, 2.18 in-in-out SNCiio in-out ActLoopNT-in 3.2221 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -114.07, 159.24 APE9-dihe-na -78.74, -160.5 APE8-dihe-in -69.68, 142.93 APE8-rot-out 53.5 APE67-dihe-in -55.96, -37.76 -73.63, -19.8 APE12-dist-in 10.3281 APE11-dist-out 7.6374 APE10-dist-out 8.5783 APE9-dist-in 5.5052 None None None XRAY 2.75 0.241 0.286 A 399.0 388.0 2 29 27 2 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6OB O75116 25 417 1388.0 5YK:501 Type1 Inactive DFGin 6.03 13.1172 BLAminus -130.02, 173.83 63.76, 84.52 -107.31, 35.45 304.31, 101.62 -71.82, -45.98 in-in in 8.6543 Saltbr-in 2.7589 HRD-in -67.3, -41.49 68.16, 2.38 in-in-out SNCiio in-out ActLoopNT-in 3.2198 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 142.81 APE8-rot-out 53.14 APE67-dihe-in -56.68, -36.81 -74.24, -19.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 B 399.0 379.0 12 29 22 7 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6OD O75116 25 417 1388.0 5YK:501 Type1 Inactive DFGin 6.0295 13.1154 BLAminus -130.14, 174.07 63.77, 84.08 -107.41, 35.57 304.55, 101.36 -72.14, -45.87 in-in in 8.6845 Saltbr-in 2.7583 HRD-in -67.39, -41.46 68.03, 2.41 in-in-out SNCiio in-out ActLoopNT-in 3.2201 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_inii APE10-dihe-na 999.0, 157.1 APE9-dihe-na 77.73, 175.48 APE8-dihe-in -69.48, 142.35 APE8-rot-out 52.81 APE67-dihe-in -56.84, -36.56 -74.86, -19.55 APE12-dist-in 9.4752 APE11-dist-none 999.0 APE10-dist-in 5.3825 APE9-dist-in 5.499 None None None XRAY 2.75 0.241 0.286 D 399.0 384.0 5 29 28 1 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6OE O75116 25 417 1388.0 5YK:501 Type1 Inactive DFGin 6.0376 13.1036 BLAminus -130.06, 173.52 64.1, 84.65 -107.82, 35.44 304.2, 101.68 -73.02, -45.03 in-in in 8.6513 Saltbr-in 2.7586 HRD-in -67.66, -41.03 68.51, 2.53 in-in-out SNCiio in-out ActLoopNT-in 3.2252 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.09 APE8-rot-out 52.96 APE67-dihe-in -55.98, -37.45 -73.98, -19.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 E 399.0 385.0 5 29 24 5 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6OF O75116 25 417 1388.0 5YK:501 Type1 Inactive DFGin 6.0289 13.1241 BLAminus -130.14, 174.06 63.83, 84.14 -107.45, 35.57 304.61, 101.55 -72.27, -45.71 in-in in 8.6797 Saltbr-in 2.7572 HRD-in -67.35, -41.53 67.92, 2.62 in-in-out SNCiio in-out ActLoopNT-in 3.2207 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.42, 157.65 APE9-dihe-na 77.78, 174.44 APE8-dihe-in -69.32, 142.43 APE8-rot-out 52.91 APE67-dihe-in -56.82, -36.56 -74.83, -19.59 APE12-dist-in 11.2408 APE11-dist-in 10.6912 APE10-dist-in 5.3659 APE9-dist-in 5.4727 None None None XRAY 2.75 0.241 0.286 F 399.0 383.0 6 29 28 1 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6PA O75116 24 417 1388.0 5YV:501 Type1 Inactive DFGin 6.1436 13.4975 BLAminus -132.07, 172.67 54.56, 93.15 -112.26, 31.75 305.01, 96.0 -65.02, -28.17 in-in in 8.9359 Saltbr-in 2.7077 HRD-in -75.76, -48.68 68.71, 2.45 in-in-out SNCiio in-out ActLoopNT-in 3.0199 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_onoo APE10-dihe-na 999.0, -37.69 APE9-dihe-na 68.06, 165.75 APE8-dihe-out 49.49, 69.05 APE8-rot-out 51.42 APE67-dihe-in -43.22, -41.5 -67.31, -24.58 APE12-dist-out 5.8964 APE11-dist-none 999.0 APE10-dist-out 8.8145 APE9-dist-out 9.313 None None None XRAY 2.82 0.222 0.258 A 399.0 389.0 1 29 28 1 [[92, 354]] 1.0 7p6p AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6PB O75116 24 417 1388.0 5YV:501 Type1 Inactive DFGin 6.1537 13.387 BLAminus -129.93, 173.86 61.04, 88.71 -108.06, 31.11 304.98, 97.36 -66.26, -28.42 in-in in 8.705 Saltbr-in 3.1205 HRD-in -76.63, -48.03 68.67, 4.31 in-in-out SNCiio in-out ActLoopNT-in 3.0234 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.26 APE8-rot-out 47.95 APE67-dihe-in -44.6, -41.1 -70.73, -25.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.82 0.222 0.258 B 399.0 374.0 15 29 17 12 [[92, 354]] 1.0 7p6p AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6PC O75116 24 417 1388.0 5YV:501 Type1 Inactive DFGin 6.183 13.4382 BLAminus -129.72, 174.14 60.9, 87.88 -108.85, 31.32 304.91, 96.4 -66.49, -26.92 in-in in 8.7175 Saltbr-in 3.1215 HRD-in -77.5, -47.77 68.57, 3.01 in-in-out SNCiio in-out ActLoopNT-in 3.0284 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.51 APE8-rot-out 47.87 APE67-dihe-in -49.24, -39.17 -68.89, -25.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.82 0.222 0.258 C 399.0 378.0 12 29 18 11 [[92, 354]] 1.0 7p6p AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6PD O75116 24 417 1388.0 5YV:501 Type1 Inactive DFGin 6.1385 13.3878 BLAminus -129.14, 174.38 61.55, 87.6 -108.19, 31.9 304.73, 96.8 -65.3, -27.92 in-in in 8.7545 Saltbr-in 3.1392 HRD-in -76.81, -47.84 67.84, 3.94 in-in-out SNCiio in-out ActLoopNT-in 3.0286 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.04, 138.37 APE9-dihe-na 76.18, 149.98 APE8-dihe-in -41.73, 133.73 APE8-rot-out 47.62 APE67-dihe-in -47.73, -39.5 -71.48, -25.27 APE12-dist-in 11.0305 APE11-dist-in 11.225 APE10-dist-in 6.1393 APE9-dist-in 5.154 None None None XRAY 2.82 0.222 0.258 D 399.0 383.0 6 29 27 2 [[92, 354]] 1.0 7p6p AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6QA O75116 24 417 1388.0 5YO:501 Type1 Inactive DFGin 6.3544 13.3521 BLAminus -144.62, 167.8 60.55, 87.07 -103.28, 32.93 301.59, 102.75 -70.91, -20.49 in-in in 8.6243 Saltbr-in 2.7039 HRD-in -68.26, -48.48 72.01, -4.52 in-in-out SNCiio in-out ActLoopNT-in 2.994 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.2 APE8-rot-out 61.47 APE67-dihe-in -43.02, -40.39 -80.11, -25.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.89 0.209 0.266 A 399.0 377.0 13 29 17 12 [[92, 354]] 1.0 7p6q AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6QB O75116 24 417 1388.0 5YO:501 Type1 Inactive DFGin 6.3 13.3089 BLAminus -144.44, 167.29 60.61, 86.93 -103.67, 32.19 301.37, 101.58 -69.29, -21.55 in-in in 8.6066 Saltbr-in 2.913 HRD-in -66.9, -49.14 71.14, -2.98 in-in-out SNCiio in-out ActLoopNT-in 2.9639 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 125.87 APE8-rot-out 59.05 APE67-dihe-in -44.93, -40.33 -80.35, -26.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.89 0.209 0.266 B 399.0 374.0 15 29 17 12 [[92, 354]] 1.0 7p6q AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6QC O75116 24 417 1388.0 5YO:501 Type1 Inactive DFGin 6.2846 13.3478 BLAminus -141.89, 172.56 57.11, 86.76 -103.5, 32.32 300.6, 102.23 -70.12, -20.17 in-in in 8.6371 Saltbr-in 2.9166 HRD-in -68.26, -48.37 71.29, -4.5 in-in-out SNCiio in-out ActLoopNT-in 2.9721 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnio APE10-dihe-na 999.0, 162.63 APE9-dihe-na 97.71, -154.08 APE8-dihe-in -75.95, 125.62 APE8-rot-out 63.5 APE67-dihe-in -42.44, -40.72 -78.86, -26.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.9414 APE9-dist-out 7.9957 None None None XRAY 2.89 0.209 0.266 C 399.0 387.0 2 29 27 2 [[92, 354]] 1.0 7p6q AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6QD O75116 24 417 1388.0 5YO:501 Type1 Inactive DFGin 6.282 13.2775 BLAminus -144.35, 168.09 60.51, 86.98 -102.62, 32.26 301.67, 102.33 -72.56, -19.6 in-in in 8.6255 Saltbr-in 2.9146 HRD-in -67.92, -48.44 71.11, -3.01 in-in-out SNCiio in-out ActLoopNT-in 2.9762 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -97.55, 159.64 APE9-dihe-na 118.49, 149.2 APE8-dihe-in -71.69, 137.89 APE8-rot-out 54.73 APE67-dihe-in -45.23, -39.33 -77.36, -30.49 APE12-dist-in 12.6103 APE11-dist-in 11.4713 APE10-dist-in 5.7837 APE9-dist-in 5.2067 None None None XRAY 2.89 0.209 0.266 D 399.0 383.0 6 29 27 2 [[92, 354]] 1.0 7p6q AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 9EP8A O75116 22 417 1388.0 A1H6L:60501 Type1 Inactive DFGin 6.4927 13.4745 BLAminus -142.27, 178.16 56.28, 74.06 -91.93, 27.01 300.49, 98.73 -80.86, -4.32 in-in in 8.4189 Saltbr-in 2.607 HRD-in -71.36, -50.57 66.41, 13.03 in-in-out SNCiio in-out ActLoopNT-in 3.2177 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -143.44, 141.63 APE9-dihe-na -72.89, -103.54 APE8-dihe-in -98.04, 136.1 APE8-rot-out 54.66 APE67-dihe-in -51.08, -38.13 -83.55, -17.15 APE12-dist-in 8.7803 APE11-dist-in 8.9625 APE10-dist-out 9.2237 APE9-dist-out 8.8182 None None None XRAY 2.63 0.203 0.242 A 402.0 388.0 2 29 27 2 [[92, 354]] 1.0 9ep8 AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 9EP8B O75116 24 417 1388.0 A1H6L:60501 Type1 Inactive DFGin 6.7218 13.6046 BLAminus -148.7, 178.5 52.93, 72.5 -93.23, 28.49 302.13, 99.55 -80.04, -2.24 in-in in 8.3809 Saltbr-in 2.629 HRD-in -69.68, -48.04 67.21, 12.72 in-in-out SNCiio in-out ActLoopNT-in 3.2414 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.96 APE8-rot-out 55.95 APE67-dihe-in -50.85, -37.73 -82.2, -18.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.63 0.203 0.242 B 402.0 373.0 16 29 17 12 [[92, 354]] 1.0 9ep8 AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 9EP8C O75116 24 417 1388.0 A1H6L:60501 Type1 Inactive DFGin 6.7875 13.6967 BLAminus -142.98, 175.13 56.66, 74.33 -94.91, 33.23 302.61, 100.99 -80.72, -3.65 in-in in 8.3304 Saltbr-in 2.6284 HRD-in -69.86, -50.69 67.71, 13.64 in-in-out SNCiio in-out ActLoopNT-in 3.2481 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.91 APE8-rot-out 55.45 APE67-dihe-in -48.54, -38.52 -80.78, -17.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.63 0.203 0.242 C 402.0 375.0 15 29 17 12 [[92, 354]] 1.0 9ep8 AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 9EP8D O75116 22 417 1388.0 A1H6L:60501 Type1 Inactive DFGin 6.533 13.5154 BLAminus -145.65, 177.68 55.35, 73.4 -93.14, 26.37 302.82, 99.26 -82.32, -4.28 in-in in 8.4987 Saltbr-in 2.6122 HRD-in -71.04, -48.63 67.32, 7.83 in-in-out SNCiio in-out ActLoopNT-in 3.2521 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -134.28, 155.4 APE9-dihe-na -71.41, -102.58 APE8-dihe-in -87.31, 137.03 APE8-rot-out 55.19 APE67-dihe-in -49.79, -38.66 -81.91, -22.13 APE12-dist-in 8.0012 APE11-dist-in 8.6831 APE10-dist-out 8.1259 APE9-dist-out 6.719 None None None XRAY 2.63 0.203 0.242 D 402.0 386.0 5 29 27 2 [[92, 354]] 1.0 9ep8 AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6OG O75116 25 417 1388.0 5YK:501 Type1.5_Front Inactive DFGin 6.0297 13.0932 BLAminus -130.18, 173.76 63.87, 84.33 -107.4, 35.32 304.41, 101.68 -72.33, -45.62 in-in in 8.6573 Saltbr-in 2.7572 HRD-in -67.47, -41.36 68.16, 2.55 in-in-out SNCiio in-out ActLoopNT-in 3.2227 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.09 APE8-rot-out 52.99 APE67-dihe-in -56.93, -36.54 -73.99, -19.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 G 399.0 381.0 8 29 24 5 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 6ED6B O75116 28 416 1388.0 J0P:501 Type1.5_Front Inactive DFGin 6.3994 13.1828 BLAminus -141.53, 178.3 54.07, 109.38 -133.99, 38.6 302.74, 88.83 -73.72, -23.58 in-in in 8.5374 Saltbr-in 2.8145 HRD-in -63.89, -44.38 75.08, -45.12 in-in-out SNCiio in-out ActLoopNT-in 3.5735 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -112.55 APE8-dihe-in -56.82, 118.75 APE8-rot-in 295.99 APE67-dihe-in -40.0, -36.43 -89.99, -12.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.0585 None None None XRAY 2.86 0.206 0.247 B 415.0 364.0 18 29 17 12 [[92, 354]] 1.0 6ed6 AGC_ROCK2_HUMAN AGC 2.6e-93 317.9 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 5U7RD O75116 25 417 1388.0 81G:500 Type1 Inactive DFGin 5.9914 13.6381 None -137.02, -44.53 -96.66, 83.52 -88.69, 16.85 303.92, 107.42 -55.18, -36.04 in-in in 8.7331 Saltbr-in 2.7396 HRD-in -81.59, -27.48 68.65, -73.51 in-in-out SNCiio in-out ActLoopNT-in 3.0332 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_onno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -137.68 APE8-dihe-in -113.15, 136.27 APE8-rot-out 64.84 APE67-dihe-in -28.57, -52.13 -70.74, -29.02 APE12-dist-out 6.8435 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.7119 None None None XRAY 3.33 0.202 0.241 D 395.0 382.0 5 29 27 2 [[92, 354]] 1.0 5u7r AGC_ROCK2_HUMAN AGC 1.7e-93 318.5 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 9JCUA O75116 27 417 1388.0 No_ligand No_ligand Inactive DFGout 15.3055 9.6194 BBAminus -122.68, 142.57 -93.88, 117.42 -92.58, 35.45 292.89, 171.91 87.13, 16.18 out-out out 14.6226 Saltbr-out 18.4867 HRD-in -80.95, -50.27 68.09, 7.79 out-in-out SNCoio in-out ActLoopNT-in 2.9616 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -127.11, 146.68 APE9-dihe-na -74.38, -64.25 APE8-dihe-in -92.78, 136.35 APE8-rot-out 52.4 APE67-dihe-in -50.05, -29.64 -108.42, 7.1 APE12-dist-in 7.3992 APE11-dist-in 9.3327 APE10-dist-in 7.2967 APE9-dist-out 9.3663 None None None XRAY 3.02 0.186 0.22 A 391.0 389.0 0 29 29 0 [[92, 354]] 1.0 9jcu AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 9JCUC O75116 27 417 1388.0 No_ligand No_ligand Inactive DFGout 15.2712 9.7649 BBAminus -106.39, 150.48 -108.17, 107.09 -89.63, 40.89 296.67, 171.34 75.24, 36.56 out-out out 14.7527 Saltbr-out 15.8781 HRD-in -75.77, -43.93 77.36, -10.14 out-in-out SNCoio in-out ActLoopNT-in 2.9219 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.94, 167.95 APE9-dihe-na 94.03, 133.64 APE8-dihe-in -78.46, 149.57 APE8-rot-out 190.58 APE67-dihe-in -65.59, -41.68 -57.26, -43.03 APE12-dist-in 9.7658 APE11-dist-in 11.57 APE10-dist-in 5.7724 APE9-dist-in 4.1616 None None None XRAY 3.02 0.186 0.22 C 391.0 389.0 0 29 29 0 [[92, 354]] 1.0 9jcu AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 8GDSA O75116 24 417 1388.0 Z8O:501 Type1 Inactive DFGout 14.304 9.3951 BBAminus -113.16, 143.54 -102.55, 117.32 -102.58, 29.06 302.77, 145.94 110.64, 5.22 out-out out 15.0791 Saltbr-out 13.9655 HRD-in -62.18, -48.44 83.82, -31.03 out-in-out SNCoio in-out ActLoopNT-in 2.8932 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -67.31, -53.4 APE9-dihe-na 75.32, -130.78 APE8-dihe-in -73.21, 128.78 APE8-rot-in 285.89 APE67-dihe-in -37.36, -36.42 -96.83, -9.21 APE12-dist-none 999.0 APE11-dist-out 7.2565 APE10-dist-out 9.8509 APE9-dist-out 9.4071 None None None XRAY 2.71 0.218 0.248 A 396.0 384.0 6 29 27 2 [[92, 354]] 1.0 8gds AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 8GDSB O75116 24 417 1388.0 Z8O:501 Type1 Inactive DFGout 14.3904 9.5098 BBAminus -111.96, 142.39 -102.56, 118.41 -101.87, 25.6 301.02, 146.14 115.08, 0.13 out-none out 14.9022 Saltbr-none 999.0 HRD-in -65.01, -47.29 71.28, -3.57 none-in-out SNCnio in-out ActLoopNT-in 2.8585 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -134.25, 147.87 APE9-dihe-na -136.74, -95.28 APE8-dihe-in -67.87, 115.24 APE8-rot-in 324.97 APE67-dihe-in -41.62, -33.28 -83.99, -16.64 APE12-dist-none 999.0 APE11-dist-out 5.672 APE10-dist-out 9.8535 APE9-dist-out 8.9466 None None None XRAY 2.71 0.218 0.248 B 396.0 384.0 6 29 26 3 [[92, 354]] 1.0 8gds AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 8GDSC O75116 24 417 1388.0 Z8O:501 Type1 Inactive DFGout 14.4465 9.4014 BBAminus -113.01, 140.92 -102.45, 117.72 -102.11, 26.89 300.53, 146.18 115.19, 0.27 out-none out 14.9991 Saltbr-none 999.0 HRD-in -64.56, -46.59 70.99, -5.08 none-in-out SNCnio in-out ActLoopNT-in 2.8871 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -88.19 APE8-dihe-in -78.06, 129.88 APE8-rot-out 60.88 APE67-dihe-in -45.28, -34.19 -66.72, -39.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.4794 None None None XRAY 2.71 0.218 0.248 C 396.0 385.0 5 29 25 4 [[92, 354]] 1.0 8gds AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 8GDSD O75116 24 417 1388.0 Z8O:501 Type1.5_Front Inactive DFGout 14.5096 9.5483 BBAminus -103.86, 141.89 -103.51, 117.86 -102.63, 25.16 306.33, 142.76 108.24, 20.62 out-none out 14.9691 Saltbr-none 999.0 HRD-in -60.5, -48.74 68.07, -4.31 none-in-none SNCnin in-none ActLoopNT-in 2.9124 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 89.84 APE9-dihe-na 170.11, -172.34 APE8-dihe-in -98.69, 124.47 APE8-rot-in 291.85 APE67-dihe-in -51.67, -33.01 -41.58, -52.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.1219 APE9-dist-in 4.5167 None None None XRAY 2.71 0.218 0.248 D 396.0 379.0 10 29 24 5 [[92, 354]] 1.0 8gds AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 9JCUB O75116 27 417 1388.0 No_ligand No_ligand Inactive DFGout 15.0932 9.676 None -123.7, 136.79 -83.22, 129.55 -106.53, 41.2 289.39, 2.91 73.26, 33.5 out-out out 14.2003 Saltbr-out 17.8227 HRD-in -77.91, -44.8 66.92, 1.93 out-in-out SNCoio in-out ActLoopNT-in 3.0397 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -105.29, 171.74 APE9-dihe-na -102.18, -85.42 APE8-dihe-in -169.86, 135.89 APE8-rot-out 176.2 APE67-dihe-in -66.86, -26.38 -54.25, -48.1 APE12-dist-in 8.648 APE11-dist-out 7.5254 APE10-dist-out 9.5573 APE9-dist-in 3.6482 None None None XRAY 3.02 0.186 0.22 B 391.0 389.0 0 29 29 0 [[92, 354]] 1.0 9jcu AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 9JCUD O75116 27 417 1388.0 No_ligand No_ligand Inactive DFGout 15.1891 10.046 None 61.51, -151.7 -108.74, 133.46 -95.46, 35.35 295.16, 171.82 82.43, 18.9 out-out out 14.6445 Saltbr-out 15.482 HRD-in -89.16, -45.56 76.26, -7.28 out-in-out SNCoio in-out ActLoopNT-in 2.9795 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.41, 151.77 APE9-dihe-na 117.7, 163.08 APE8-dihe-in -78.12, 141.11 APE8-rot-out 189.43 APE67-dihe-in -63.04, -33.79 -53.94, -34.75 APE12-dist-in 11.0414 APE11-dist-in 11.5892 APE10-dist-in 5.9519 APE9-dist-in 4.4577 None None None XRAY 3.02 0.186 0.22 D 391.0 387.0 0 29 29 0 [[92, 354]] 1.0 9jcu AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7JOVB O75116 23 417 1388.0 VFS:501 Type1 None DFGin 6.2716 13.2483 BLAminus -142.1, 173.55 61.9, 71.69 -93.43, 17.34 301.23, 105.57 -59.73, -16.68 in-in in 8.5286 Saltbr-in 2.6299 HRD-in -62.93, -47.02 69.4, -4.67 in-in-none SNCiin in-none ActLoopNT-in 3.0977 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -66.0, -25.51 999.0, -48.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 B 395.0 378.0 11 29 21 8 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7JOVD O75116 25 417 1388.0 VFS:501 Type1 None DFGin 6.2428 13.3572 BLAminus -142.23, 173.1 61.78, 71.13 -91.99, 20.3 301.3, 105.37 -69.47, 5.8 in-in in 8.6714 Saltbr-in 2.7008 HRD-in -54.87, -50.75 69.64, -5.46 in-in-none SNCiin in-none ActLoopNT-in 3.1806 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -32.28 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 D 395.0 361.0 26 29 14 15 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7JOVE O75116 23 417 1388.0 VFS:501 Type1 None DFGin 6.2985 13.2567 BLAminus -140.47, 172.73 62.89, 72.53 -94.4, 16.26 301.6, 106.26 -62.28, -16.19 in-in in 8.4545 Saltbr-in 2.7399 HRD-in -64.4, -46.2 69.9, -8.61 in-in-none SNCiin in-none ActLoopNT-in 3.1263 ActLoopCT-none nonTYR APEdihe_aanii APEdist_innn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.7 APE8-rot-in 314.77 APE67-dihe-in -47.56, -31.02 -61.45, -35.46 APE12-dist-in 8.281 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 E 395.0 385.0 4 29 26 3 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7JNTB O75116 23 417 1388.0 VFA:501 Type1 None DFGin 6.1649 13.1214 BLAminus -141.64, 172.76 58.92, 82.45 -101.4, 24.85 302.94, 103.08 -64.88, -17.44 in-in in 8.6979 Saltbr-in 2.7387 HRD-in -62.47, -54.27 74.29, -0.05 in-in-none SNCiin in-none ActLoopNT-in 2.9957 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -59.99, -27.47 999.0, -54.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 B 399.0 376.0 13 29 21 8 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7JNTD O75116 25 417 1388.0 VFA:501 Type1 None DFGin 6.1586 13.1604 BLAminus -143.53, 169.89 61.25, 83.67 -103.29, 25.02 302.97, 101.79 -66.66, -17.12 in-in in 8.7301 Saltbr-in 2.7399 HRD-in -61.61, -54.54 74.16, -0.65 in-in-none SNCiin in-none ActLoopNT-in 2.9935 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -35.7 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 D 399.0 360.0 27 29 14 15 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7JNTE O75116 23 417 1388.0 VFA:501 Type1 None DFGin 6.2142 13.058 BLAminus -142.23, 169.06 60.85, 86.77 -104.6, 25.19 302.23, 103.83 -66.31, -19.22 in-in in 8.5732 Saltbr-in 2.6677 HRD-in -56.89, -52.9 74.38, -3.32 in-in-none SNCiin in-none ActLoopNT-in 3.0436 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 73.83 APE8-rot-in 306.93 APE67-dihe-in -51.63, -28.56 -78.96, -16.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 E 399.0 384.0 5 29 25 4 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6NC O75116 23 417 1388.0 5YS:501 Type1 None DFGin 5.9336 12.9198 BLAminus -146.55, 173.64 55.03, 95.19 -112.85, 21.67 306.28, 93.38 -46.66, -30.29 in-in in 8.6716 Saltbr-in 2.8448 HRD-in -68.54, -48.47 75.35, -77.76 in-in-none SNCiin in-none ActLoopNT-in 3.1882 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -54.16, -41.45 999.0, -46.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 C 399.0 378.0 12 29 23 6 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6NE O75116 23 417 1388.0 5YS:501 Type1 None DFGin 5.9547 12.8666 BLAminus -145.98, 174.14 54.43, 95.4 -112.52, 20.29 306.04, 93.17 -47.1, -30.89 in-in in 8.6001 Saltbr-in 2.8492 HRD-in -68.77, -48.13 75.51, -77.25 in-in-none SNCiin in-none ActLoopNT-in 3.1937 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -55.16, -41.37 999.0, -45.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 E 399.0 385.0 6 29 23 6 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6NH O75116 25 417 1388.0 5YS:501 Type1 None DFGin 5.9239 12.9869 BLAminus -147.12, 173.74 54.77, 95.23 -112.35, 21.15 305.58, 93.62 -44.02, -31.78 in-in in 8.7536 Saltbr-in 2.8397 HRD-in -68.48, -48.35 74.56, -77.19 in-in-none SNCiin in-none ActLoopNT-in 3.1944 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.65, -39.86 999.0, -45.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 H 399.0 366.0 23 29 14 15 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6OC O75116 22 417 1388.0 5YK:501 Type1.5_Front None DFGin 6.0199 13.0977 BLAminus -129.77, 174.02 63.85, 83.94 -107.22, 35.66 304.43, 101.43 -71.69, -46.2 in-in in 8.6693 Saltbr-in 2.758 HRD-in -67.24, -41.54 67.86, 2.47 in-in-none SNCiin in-none ActLoopNT-in 3.2217 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.0, -37.44 999.0, -18.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 C 399.0 377.0 13 29 22 7 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 7P6OH O75116 24 417 1388.0 5YK:501 Type1.5_Front None DFGin 6.0306 13.1422 BLAminus -130.18, 173.86 63.9, 84.23 -107.39, 35.65 304.66, 101.19 -71.86, -45.96 in-in in 8.6848 Saltbr-in 2.7574 HRD-in -67.2, -41.51 67.93, 2.34 in-in-none SNCiin in-none ActLoopNT-in 3.2184 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.17, -36.5 999.0, -17.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 H 399.0 369.0 19 29 15 14 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2

AGC_ROCK2 (Rho-associated protein kinase 2)

Total number of chains: 90
Active chains: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 55 61.1% AF-O75116-K1A
DFGin ABAminus 26 28.9% 8X92A
DFGout BBAminus 6 6.7% 9JCUA
DFGout None 2 2.2% 9JCUB
DFGin None 1 1.1% 5U7RD

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ROCK2 ROCK2_BOVIN 2F2UA Q28021 27 417 1388.0 M77:501 Type1 Inactive DFGin 6.1545 13.9643 ABAminus -125.36, 20.74 -155.97, 132.58 -140.63, 28.66 305.18, 93.77 -61.1, -20.63 in-in in 9.2012 Saltbr-in 2.8484 HRD-in -71.0, -56.95 70.45, 14.05 in-in-out SNCiio in-out ActLoopNT-in 3.1004 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.24, 160.08 APE9-dihe-na 106.51, 163.99 APE8-dihe-in -75.45, 135.55 APE8-rot-out 188.78 APE67-dihe-in -58.72, -25.7 -36.99, -50.18 APE12-dist-in 9.876 APE11-dist-in 11.6551 APE10-dist-in 5.7528 APE9-dist-in 3.7744 None None None XRAY 2.4 0.197 0.235 A 402.0 386.0 0 29 29 0 [[92, 354]] 1.0 2f2u Bos taurus AGC_ROCK2_BOVIN AGC 2.6e-93 317.9 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_BOVIN 2H9VA Q28021 25 417 1388.0 Y27:500 Type1 Inactive DFGin 5.8532 13.3743 ABAminus -112.95, -9.44 -122.76, 149.79 -143.58, -5.13 306.08, 85.41 -38.72, -9.58 in-in in 9.2032 Saltbr-in 2.7224 HRD-in -79.43, -50.38 70.18, 0.12 in-in-in SNCiii in-in ActLoopNT-in 2.9979 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.4, 143.53 APE9-dihe-na 126.28, -170.44 APE8-dihe-in -95.31, 128.27 APE8-rot-in 291.56 APE67-dihe-in -48.07, -17.55 -32.2, -61.95 APE12-dist-in 10.1405 APE11-dist-in 11.4795 APE10-dist-in 5.8196 APE9-dist-in 4.2608 None None None XRAY 3.1 0.234 0.277 A 402.0 383.0 0 29 29 0 [[92, 354]] 1.0 2h9v Bos taurus AGC_ROCK2_BOVIN AGC 2.6e-93 317.9 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_BOVIN 2F2UB Q28021 27 417 1388.0 M77:1501 Type1 Inactive DFGin 6.1606 13.2523 BLAminus -137.47, 174.34 55.62, 88.13 -108.95, 28.93 305.37, 102.14 -67.94, -16.5 in-in in 8.3564 Saltbr-in 3.0307 HRD-in -77.45, -48.84 68.99, 13.39 in-in-out SNCiio in-out ActLoopNT-in 2.9443 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -93.52, 138.42 APE9-dihe-na -106.28, -104.32 APE8-dihe-in -64.29, 128.15 APE8-rot-in 304.0 APE67-dihe-in -52.28, -37.75 -95.33, 10.69 APE12-dist-out 5.1639 APE11-dist-in 9.6251 APE10-dist-out 10.1166 APE9-dist-out 9.097 None None None XRAY 2.4 0.197 0.235 B 402.0 383.0 0 29 29 0 [[92, 354]] 1.0 2f2u Bos taurus AGC_ROCK2_BOVIN AGC 2.6e-93 317.9 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN AF-O75116-K1A O75116 84 362 1388.0 No_ligand No_ligand Active DFGin 5.8685 12.9149 BLAminus -136.99, 177.96 53.48, 73.71 -86.19, 14.62 307.2, 104.5 -65.86, -9.9 in-in in 8.7312 Saltbr-in 2.6513 HRD-in -85.23, -49.89 67.76, 1.46 in-in-in SNCiii in-in ActLoopNT-in 2.9592 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.28, 135.21 APE9-dihe-na 135.69, 171.46 APE8-dihe-in -70.75, 130.03 APE8-rot-in 300.74 APE67-dihe-in -77.08, -19.45 -51.29, -40.8 APE12-dist-in 10.4853 APE11-dist-in 11.5675 APE10-dist-in 5.7555 APE9-dist-in 3.6338 None None None AF2 -1.0 1.0 1.0 A 279.0 279.0 0 29 29 0 [[92, 354]] 1.0 AF-O75116-K1 Homo sapiens AGC_ROCK2_HUMAN AGC 6.9e-94 319.7 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN AF-O75116-K3A O75116 84 362 1388.0 No_ligand No_ligand Active DFGin 5.8197 13.4492 BLAminus -136.65, 179.19 54.41, 68.61 -80.36, 13.1 307.71, 103.33 -65.49, -10.01 in-in in 8.6735 Saltbr-in 2.629 HRD-in -85.92, -46.0 66.47, 0.5 in-in-in SNCiii in-in ActLoopNT-in 2.9361 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.35, 142.1 APE9-dihe-na 129.39, 171.44 APE8-dihe-in -69.98, 129.02 APE8-rot-in 286.32 APE67-dihe-in -70.68, -17.36 -43.25, -51.09 APE12-dist-in 10.6353 APE11-dist-in 11.9406 APE10-dist-in 6.0099 APE9-dist-in 3.2627 None None None AF2 -1.0 1.0 1.0 A 279.0 279.0 0 29 29 0 [[92, 354]] 1.0 AF-O75116-K3 Homo sapiens AGC_ROCK2_HUMAN AGC 6.9e-94 319.7 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 8X8XA O75116 32 417 1388.0 YDW:501 Type1 Active DFGin 6.3582 13.6185 BLAminus -145.81, -178.89 53.82, 76.54 -97.16, 31.49 303.8, 87.87 -66.69, -28.82 in-in in 8.9565 Saltbr-in 2.6653 HRD-in -74.39, -58.56 77.08, -1.86 in-in-in SNCiii in-in ActLoopNT-in 2.9686 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.16, 162.89 APE9-dihe-na 114.79, -140.41 APE8-dihe-in -127.19, 138.75 APE8-rot-in 307.63 APE67-dihe-in -63.05, -28.14 -61.81, -39.49 APE12-dist-in 10.3965 APE11-dist-in 11.7049 APE10-dist-in 5.8573 APE9-dist-in 3.7996 None None None XRAY 2.6 0.201 0.253 A 391.0 380.0 0 29 29 0 [[92, 354]] 1.0 8x8x Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 6ED6A O75116 27 415 1388.0 J0P:501 Type1 Active DFGin 6.4785 13.3609 BLAminus -145.19, 179.01 60.98, 63.29 -87.07, 23.13 303.43, 107.85 -60.41, -48.86 in-in in 8.5317 Saltbr-in 2.7436 HRD-in -56.44, -54.27 71.45, -18.59 in-in-in SNCiii in-in ActLoopNT-in 3.4387 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.8, 126.02 APE9-dihe-na 153.03, -163.23 APE8-dihe-in -114.06, 130.07 APE8-rot-in 328.57 APE67-dihe-in -55.65, -29.13 -25.97, -72.15 APE12-dist-in 10.492 APE11-dist-in 11.3819 APE10-dist-in 5.5534 APE9-dist-in 3.9599 None None None XRAY 2.86 0.206 0.247 A 415.0 378.0 4 29 29 0 [[92, 354]] 1.0 6ed6 Homo sapiens AGC_ROCK2_HUMAN AGC 2.6e-93 317.9 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 6P5MC O75116 18 417 1388.0 No_ligand No_ligand Inactive DFGin 6.2844 13.9214 ABAminus -122.7, -9.78 -139.64, 138.02 -140.63, 30.64 305.79, 99.12 -60.86, -31.72 in-in in 9.232 Saltbr-in 2.9118 HRD-in -79.08, -59.4 80.67, -6.5 in-in-in SNCiii in-in ActLoopNT-in 2.9615 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.73, 160.25 APE9-dihe-na 91.47, 176.97 APE8-dihe-in -75.63, 130.45 APE8-rot-in 321.11 APE67-dihe-in -50.51, -34.84 -49.48, -49.9 APE12-dist-in 9.7395 APE11-dist-in 11.5255 APE10-dist-in 5.4867 APE9-dist-in 3.9004 F270Y None None XRAY 2.65 0.195 0.225 C 405.0 395.0 0 29 29 0 [[92, 354]] 1.0 6p5m Homo sapiens AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 6P5MD O75116 18 417 1388.0 No_ligand No_ligand Inactive DFGin 6.2848 13.9358 ABAminus -122.32, -12.13 -136.93, 137.32 -138.61, 32.6 305.2, 99.15 -64.64, -30.48 in-in in 9.2036 Saltbr-in 2.9023 HRD-in -80.83, -60.28 80.37, -5.42 in-in-in SNCiii in-in ActLoopNT-in 2.9724 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.85, 159.37 APE9-dihe-na 92.74, 176.75 APE8-dihe-in -76.16, 130.74 APE8-rot-in 321.06 APE67-dihe-in -51.46, -34.25 -48.82, -49.31 APE12-dist-in 9.4784 APE11-dist-in 11.3216 APE10-dist-in 5.2947 APE9-dist-in 3.9097 F270Y None None XRAY 2.65 0.195 0.225 D 405.0 395.0 0 29 29 0 [[92, 354]] 1.0 6p5m Homo sapiens AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 5U7QA O75116 25 417 1388.0 No_ligand No_ligand Inactive DFGin 6.259 13.944 ABAminus -118.38, -30.33 -115.44, 138.21 -136.2, 22.48 302.79, 98.72 -67.44, -9.24 in-in in 9.3453 Saltbr-in 2.8508 HRD-in -71.59, -51.25 68.38, 10.85 in-in-out SNCiio in-out ActLoopNT-in 3.0532 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -145.07, 165.16 APE9-dihe-na 99.44, -174.88 APE8-dihe-in -110.13, 133.98 APE8-rot-out 71.35 APE67-dihe-in -43.56, -39.21 -47.25, -61.0 APE12-dist-in 10.3063 APE11-dist-in 11.5193 APE10-dist-in 5.8232 APE9-dist-in 3.5958 None None None XRAY 3.15 0.206 0.235 A 395.0 388.0 0 29 29 0 [[92, 354]] 1.0 5u7q Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 5U7QB O75116 28 417 1388.0 No_ligand No_ligand Inactive DFGin 6.2579 13.8385 ABAminus -117.94, -31.05 -114.29, 137.07 -135.84, 23.64 304.14, 98.35 -71.27, -7.96 in-in in 9.202 Saltbr-in 2.8042 HRD-in -69.76, -50.21 70.12, 10.28 in-in-out SNCiio in-out ActLoopNT-in 3.0836 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na -101.5, 136.43 APE9-dihe-na -97.06, -173.07 APE8-dihe-out 0.71, 109.2 APE8-rot-out 79.45 APE67-dihe-in -42.62, -39.27 -78.6, -9.02 APE12-dist-out 6.3232 APE11-dist-in 9.744 APE10-dist-out 9.5726 APE9-dist-out 9.45 None None None XRAY 3.15 0.206 0.235 B 395.0 385.0 0 29 29 0 [[92, 354]] 1.0 5u7q Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 5U7QC O75116 23 417 1388.0 No_ligand No_ligand Inactive DFGin 6.24 13.9492 ABAminus -118.61, -31.03 -114.56, 138.0 -135.58, 22.3 302.64, 98.81 -68.71, -8.98 in-in in 9.306 Saltbr-in 2.8457 HRD-in -71.74, -50.43 70.98, 8.22 in-in-out SNCiio in-out ActLoopNT-in 3.0654 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -143.91, 164.09 APE9-dihe-na 99.24, -172.98 APE8-dihe-in -112.36, 135.32 APE8-rot-out 71.33 APE67-dihe-in -43.59, -38.66 -47.45, -62.01 APE12-dist-in 10.3606 APE11-dist-in 11.5839 APE10-dist-in 5.8568 APE9-dist-in 3.5914 None None None XRAY 3.15 0.206 0.235 C 395.0 390.0 0 29 29 0 [[92, 354]] 1.0 5u7q Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 5U7QD O75116 27 417 1388.0 No_ligand No_ligand Inactive DFGin 6.2675 13.8702 ABAminus -117.71, -31.1 -114.96, 137.38 -136.24, 22.53 303.71, 99.02 -69.56, -9.33 in-in in 9.2534 Saltbr-in 2.8169 HRD-in -70.86, -50.66 64.9, 13.18 in-in-out SNCiio in-out ActLoopNT-in 3.0696 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiio APE10-dihe-na 129.84, 128.46 APE9-dihe-na 155.49, 162.77 APE8-dihe-in -98.68, 133.35 APE8-rot-out 69.96 APE67-dihe-out 26.46, -59.82 -69.88, -74.55 APE12-dist-in 10.2594 APE11-dist-in 9.2478 APE10-dist-in 6.5691 APE9-dist-out 7.7537 None None None XRAY 3.15 0.206 0.235 D 395.0 383.0 3 29 26 3 [[92, 354]] 1.0 5u7q Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 5U7RA O75116 25 417 1388.0 81G:500 Type1 Inactive DFGin 6.021 13.3928 ABAminus -124.59, -51.34 -100.7, 98.55 -98.24, 10.15 301.55, 107.52 -53.67, -30.47 in-in in 8.8797 Saltbr-in 2.6738 HRD-in -86.61, -51.16 76.24, -9.42 in-in-out SNCiio in-out ActLoopNT-in 2.8386 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -101.07, 144.01 APE9-dihe-na 118.28, 178.92 APE8-dihe-in -78.19, 127.98 APE8-rot-out 37.97 APE67-dihe-in -75.92, -25.7 -48.83, -32.29 APE12-dist-in 10.0319 APE11-dist-in 11.6475 APE10-dist-in 5.6575 APE9-dist-in 4.1525 None None None XRAY 3.33 0.202 0.241 A 395.0 387.0 0 29 29 0 [[92, 354]] 1.0 5u7r Homo sapiens AGC_ROCK2_HUMAN AGC 1.7e-93 318.5 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 5U7RC O75116 25 417 1388.0 81G:500 Type1 Inactive DFGin 5.9386 13.56 ABAminus -130.76, -53.46 -102.99, 94.4 -95.45, 17.91 300.98, 105.74 -67.72, -17.68 in-in in 8.525 Saltbr-in 2.8749 HRD-in -81.89, -48.76 85.63, -53.94 in-in-out SNCiio in-out ActLoopNT-in 3.1423 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiio APE10-dihe-na -119.26, 144.44 APE9-dihe-na -73.26, -103.48 APE8-dihe-in -77.65, 129.34 APE8-rot-out 33.83 APE67-dihe-in -30.2, -56.76 -78.66, -11.76 APE12-dist-out 6.0426 APE11-dist-in 9.4249 APE10-dist-in 7.6671 APE9-dist-out 9.9332 None None None XRAY 3.33 0.202 0.241 C 395.0 387.0 0 29 29 0 [[92, 354]] 1.0 5u7r Homo sapiens AGC_ROCK2_HUMAN AGC 1.7e-93 318.5 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 6P5PA O75116 27 417 1388.0 O1V:2500 Type1 Inactive DFGin 6.1 13.7982 ABAminus -140.54, -38.15 -103.07, 135.03 -138.91, 13.89 292.53, 107.02 -62.06, -18.82 in-in in 9.0441 Saltbr-in 2.7049 HRD-in -91.96, -54.28 90.29, -35.29 in-in-out SNCiio in-out ActLoopNT-in 3.0978 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.88, 157.67 APE9-dihe-na 95.31, 171.85 APE8-dihe-in -89.1, 136.7 APE8-rot-out 43.44 APE67-dihe-in -58.47, -37.34 -54.83, -41.99 APE12-dist-in 9.8535 APE11-dist-in 11.647 APE10-dist-in 5.6416 APE9-dist-in 4.5055 F270Y None None XRAY 3.3 0.207 0.236 A 405.0 386.0 0 29 29 0 [[92, 354]] 1.0 6p5p Homo sapiens AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 6P5PB O75116 27 417 1388.0 O1V:2500 Type1 Inactive DFGin 6.0895 13.6668 ABAminus -142.64, -37.41 -103.44, 133.69 -139.28, 14.63 293.57, 107.2 -60.04, -21.17 in-in in 8.7166 Saltbr-in 2.7128 HRD-in -86.41, -51.75 93.44, -45.12 in-in-out SNCiio in-out ActLoopNT-in 3.1147 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnio APE10-dihe-na 999.0, 98.93 APE9-dihe-na 96.49, 160.02 APE8-dihe-out -136.03, -48.15 APE8-rot-out 58.37 APE67-dihe-out -95.66, -8.92 -10.89, 163.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.8432 APE9-dist-out 7.7851 F270Y None None XRAY 3.3 0.207 0.236 B 405.0 369.0 11 29 24 5 [[92, 354]] 1.0 6p5p Homo sapiens AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 6P5PC O75116 28 416 1388.0 O1V:2500 Type1 Inactive DFGin 6.0585 13.7793 ABAminus -141.44, -37.71 -103.72, 135.03 -139.29, 13.77 292.2, 107.44 -61.16, -19.58 in-in in 9.0196 Saltbr-in 2.5842 HRD-in -89.59, -53.69 91.0, -37.17 in-in-out SNCiio in-out ActLoopNT-in 3.0972 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.85, 160.08 APE9-dihe-na 94.19, 175.02 APE8-dihe-in -83.56, 138.16 APE8-rot-out 27.44 APE67-dihe-in -59.59, -38.55 -52.39, -43.92 APE12-dist-in 9.8679 APE11-dist-in 11.697 APE10-dist-in 5.6986 APE9-dist-in 4.6141 F270Y None None XRAY 3.3 0.207 0.236 C 405.0 375.0 9 29 29 0 [[92, 354]] 1.0 6p5p Homo sapiens AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 6P5PD O75116 26 416 1388.0 O1V:2500 Type1 Inactive DFGin 6.0632 13.5384 ABAminus -142.31, -37.19 -102.73, 133.81 -138.95, 14.8 293.03, 107.98 -61.89, -20.52 in-in in 8.7293 Saltbr-in 3.0028 HRD-in -87.78, -50.98 94.3, -44.63 in-in-out SNCiio in-out ActLoopNT-in 3.1052 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na 142.21, 160.44 APE9-dihe-na 98.4, 160.87 APE8-dihe-in -91.67, 134.46 APE8-rot-out 44.39 APE67-dihe-in -35.6, -42.17 -54.98, -42.29 APE12-dist-in 8.5396 APE11-dist-in 10.2333 APE10-dist-in 6.8652 APE9-dist-out 8.0997 F270Y None None XRAY 3.3 0.207 0.236 D 405.0 382.0 4 29 28 1 [[92, 354]] 1.0 6p5p Homo sapiens AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 8X8YB O75116 29 417 1388.0 YEA:501 Type1 Inactive DFGin 6.1449 13.0959 ABAminus -143.12, -33.94 -106.09, 93.06 -90.35, 19.08 311.7, 96.3 -43.48, -33.82 in-in in 8.2745 Saltbr-in 2.7029 HRD-out -97.55, 96.59 -73.9, -11.34 in-in-out SNCiio in-out ActLoopNT-in 2.6759 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -120.75, 154.61 APE9-dihe-na -77.81, -131.7 APE8-dihe-in -64.67, 142.4 APE8-rot-in 325.66 APE67-dihe-in -41.68, -27.46 -83.12, -16.83 APE12-dist-in 7.4742 APE11-dist-in 8.0672 APE10-dist-in 6.6236 APE9-dist-out 9.5857 None None None XRAY 3.2 0.185 0.243 B 391.0 381.0 2 29 27 2 [[92, 354]] 1.0 8x8y Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 8X8ZA O75116 31 416 1388.0 YEI:501 Type1 Inactive DFGin 6.2225 13.3215 ABAminus -137.94, -35.4 -107.28, 98.66 -104.78, 35.55 309.08, 94.51 -70.09, -34.82 in-in in 8.6253 Saltbr-in 2.5135 HRD-in -74.7, -54.55 74.9, -7.49 in-in-in SNCiii in-in ActLoopNT-in 2.9733 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.04, 159.96 APE9-dihe-na 107.67, -142.65 APE8-dihe-in -117.59, 137.7 APE8-rot-in 304.03 APE67-dihe-in -63.05, -29.24 -60.27, -42.21 APE12-dist-in 9.9482 APE11-dist-in 11.4541 APE10-dist-in 5.5693 APE9-dist-in 3.9424 None None None XRAY 2.7 0.202 0.255 A 391.0 379.0 0 29 29 0 [[92, 354]] 1.0 8x8z Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 8X8ZB O75116 29 417 1388.0 YEI:501 Type1 Inactive DFGin 6.1982 13.0715 ABAminus -136.69, -32.87 -113.62, 107.48 -108.59, 37.17 307.49, 93.35 -67.13, -33.87 in-in in 8.4703 Saltbr-in 3.2116 HRD-in -75.89, -53.13 77.36, -18.94 in-in-out SNCiio in-out ActLoopNT-in 3.1029 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -120.39, 156.94 APE9-dihe-na -95.08, -124.51 APE8-dihe-in -71.89, 132.74 APE8-rot-in 281.12 APE67-dihe-in -52.91, -35.61 -79.81, -3.34 APE12-dist-out 6.2225 APE11-dist-in 8.1162 APE10-dist-in 6.3964 APE9-dist-out 9.0684 None None None XRAY 2.7 0.202 0.255 B 391.0 376.0 7 29 22 7 [[92, 354]] 1.0 8x8z Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 8X92A O75116 29 416 1388.0 YEW:501 Type1 Inactive DFGin 6.2828 13.5091 ABAminus -130.17, -37.88 -106.77, 98.05 -102.95, 26.89 303.41, 99.6 -63.14, -27.04 in-in in 8.5046 Saltbr-in 2.3441 HRD-in -76.14, -56.17 76.65, -10.0 in-in-in SNCiii in-in ActLoopNT-in 3.0965 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.17, 164.81 APE9-dihe-na 100.98, -149.71 APE8-dihe-in -115.92, 137.43 APE8-rot-in 295.58 APE67-dihe-in -63.22, -26.51 -58.54, -42.75 APE12-dist-in 10.1553 APE11-dist-in 11.5226 APE10-dist-in 5.6808 APE9-dist-in 3.7573 None None None XRAY 2.2 0.209 0.24 A 391.0 384.0 0 29 29 0 [[92, 354]] 1.0 8x92 Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 8X92B O75116 29 417 1388.0 YEW:501 Type1 Inactive DFGin 6.3901 13.3512 ABAminus -130.25, -35.39 -108.15, 104.62 -106.39, 29.3 307.45, 100.77 -61.59, -28.54 in-in in 8.3473 Saltbr-in 2.9402 HRD-in -76.68, -52.79 78.59, -25.26 in-in-out SNCiio in-out ActLoopNT-in 3.0915 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_noio APE10-dihe-na -131.54, -42.51 APE9-dihe-na 102.33, -143.39 APE8-dihe-in -75.11, 133.17 APE8-rot-out 81.17 APE67-dihe-in -53.78, -31.77 -93.71, 6.6 APE12-dist-none 999.0 APE11-dist-out 7.6747 APE10-dist-in 6.5685 APE9-dist-out 9.5363 None None None XRAY 2.2 0.209 0.24 B 391.0 368.0 15 29 19 10 [[92, 354]] 1.0 8x92 Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 4WOTA O75116 22 417 1388.0 3SG:501 Type1 Inactive DFGin 6.1945 13.074 ABAminus -135.17, -10.51 -134.2, 128.83 -131.16, 28.81 310.32, 108.74 -62.4, -34.78 in-in in 8.967 Saltbr-in 2.447 HRD-in -67.9, -48.5 51.03, 22.17 in-in-out SNCiio in-out ActLoopNT-in 2.9899 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 151.53 APE9-dihe-na 148.47, -177.25 APE8-dihe-in -79.02, 124.53 APE8-rot-out 69.87 APE67-dihe-in -33.84, -49.13 -87.01, 2.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.5577 APE9-dist-out 7.9832 None None None XRAY 2.93 0.223 0.268 A 396.0 389.0 3 29 26 3 [[92, 354]] 1.0 4wot Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 4WOTB O75116 22 417 1388.0 3SG:501 Type1 Inactive DFGin 6.2061 13.412 ABAminus -121.15, -29.83 -129.18, 101.54 -100.78, 25.44 307.28, 101.28 -60.27, -29.91 in-in in 9.2394 Saltbr-in 2.5551 HRD-in -73.23, -53.38 48.65, 30.57 in-in-in SNCiii in-in ActLoopNT-in 3.0139 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.19, 136.46 APE9-dihe-na 130.7, 169.23 APE8-dihe-in -78.33, 140.31 APE8-rot-in 315.87 APE67-dihe-in -66.72, -32.79 -54.96, -39.47 APE12-dist-in 10.2698 APE11-dist-in 11.1208 APE10-dist-in 5.4011 APE9-dist-in 3.961 None None None XRAY 2.93 0.223 0.268 B 396.0 394.0 0 29 29 0 [[92, 354]] 1.0 4wot Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 4WOTC O75116 22 417 1388.0 3SG:501 Type1 Inactive DFGin 6.3975 13.1365 ABAminus -155.48, 37.05 -162.57, 126.3 -126.94, 37.81 307.24, 97.39 -72.68, -39.98 in-in in 8.8532 Saltbr-in 2.7026 HRD-in -72.02, -52.38 47.81, 35.39 in-in-in SNCiii in-in ActLoopNT-in 3.0572 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.22, 153.14 APE9-dihe-na 111.79, 170.52 APE8-dihe-in -74.42, 135.59 APE8-rot-in 311.52 APE67-dihe-in -64.13, -31.94 -46.85, -44.87 APE12-dist-in 10.3652 APE11-dist-in 11.1725 APE10-dist-in 5.5084 APE9-dist-in 4.1825 None None None XRAY 2.93 0.223 0.268 C 396.0 392.0 0 29 29 0 [[92, 354]] 1.0 4wot Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 4WOTD O75116 23 417 1388.0 3SG:501 Type1 Inactive DFGin 6.2523 13.2573 ABAminus -118.96, -34.54 -121.89, 101.62 -103.9, 33.36 309.85, 95.26 -70.03, -28.11 in-in in 9.0867 Saltbr-in 2.4432 HRD-in -70.37, -47.18 69.99, 3.47 in-in-out SNCiio in-out ActLoopNT-in 2.9303 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -161.47, 159.03 APE9-dihe-na 169.18, 177.89 APE8-dihe-in -96.13, 131.57 APE8-rot-out 64.42 APE67-dihe-in -46.94, -47.22 -87.02, 3.22 APE12-dist-none 999.0 APE11-dist-out 7.5647 APE10-dist-out 8.7203 APE9-dist-out 7.9469 None None None XRAY 2.93 0.223 0.268 D 396.0 389.0 2 29 27 2 [[92, 354]] 1.0 4wot Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 9HFPA O75116 23 417 1388.0 A1IUI:501 Type1 Inactive DFGin 6.3249 13.4859 ABAminus -116.81, -23.83 -103.61, 131.6 -131.15, 17.95 300.42, 103.4 -50.91, -44.1 in-in in 8.775 Saltbr-in 2.9731 HRD-in -60.74, -61.14 76.47, -4.94 in-in-in SNCiii in-in ActLoopNT-in 3.0445 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.76, 160.47 APE9-dihe-na 106.89, -168.78 APE8-dihe-in -100.64, 133.74 APE8-rot-in 307.74 APE67-dihe-in -64.45, -23.8 -40.67, -47.85 APE12-dist-in 10.2329 APE11-dist-in 11.3544 APE10-dist-in 5.4907 APE9-dist-in 3.677 None None None XRAY 2.92 0.206 0.22 A 396.0 391.0 0 29 29 0 [[92, 354]] 1.0 9hfp Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 4L6QA O75116 27 417 1388.0 1WU:501 Type1 Inactive DFGin 6.3025 13.5702 ABAminus -116.27, -49.25 -107.45, 128.66 -126.56, 33.88 304.03, 88.55 -72.5, -17.13 in-in in 8.8823 Saltbr-in 2.672 HRD-in -73.76, -46.68 73.56, -20.06 in-in-out SNCiio in-out ActLoopNT-in 2.9796 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -127.31, 131.57 APE9-dihe-na 145.53, -153.1 APE8-dihe-in -136.66, 121.88 APE8-rot-out 181.69 APE67-dihe-in -54.43, -25.79 -36.79, -58.64 APE12-dist-in 10.6283 APE11-dist-in 11.4732 APE10-dist-in 5.6957 APE9-dist-in 3.9166 None None None XRAY 2.79 0.224 0.281 A 402.0 388.0 0 29 29 0 [[92, 354]] 1.0 4l6q Homo sapiens AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 4L6QB O75116 27 417 1388.0 1WU:501 Type1 Inactive DFGin 6.2412 13.4208 ABAminus -107.91, -62.87 -88.93, 144.15 -141.39, 24.98 298.39, 99.37 -69.99, -11.39 in-out in 8.7899 Saltbr-out 4.2152 HRD-in -77.55, -55.12 77.74, -6.89 out-in-in SNCoii in-in ActLoopNT-in 3.1737 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.98, 112.76 APE9-dihe-na 161.13, -165.93 APE8-dihe-in -114.84, 120.25 APE8-rot-in 312.46 APE67-dihe-in -62.07, -22.46 -26.22, -64.13 APE12-dist-in 10.2175 APE11-dist-in 11.4445 APE10-dist-in 5.753 APE9-dist-in 3.7448 None None None XRAY 2.79 0.224 0.281 B 402.0 388.0 0 29 29 0 [[92, 354]] 1.0 4l6q Homo sapiens AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 5U7RB O75116 25 417 1388.0 81G:500 Type1 Inactive DFGin 5.7545 13.641 BLAminus -141.67, 175.83 55.92, 92.76 -111.9, 4.36 301.65, 97.85 -69.51, 58.89 in-in in 8.8502 Saltbr-in 2.5587 HRD-in -72.3, -58.92 77.62, -4.98 in-in-out SNCiio in-out ActLoopNT-in 3.0494 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -76.98, 141.69 APE9-dihe-na 134.81, 151.0 APE8-dihe-in -74.28, 133.5 APE8-rot-out 61.19 APE67-dihe-in -51.66, -36.53 -38.48, -66.38 APE12-dist-in 9.9046 APE11-dist-in 11.8182 APE10-dist-in 5.7763 APE9-dist-in 3.6428 None None None XRAY 3.33 0.202 0.241 B 395.0 387.0 0 29 29 0 [[92, 354]] 1.0 5u7r Homo sapiens AGC_ROCK2_HUMAN AGC 1.7e-93 318.5 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 6P5MA O75116 18 417 1388.0 O1S:62500 Type1 Inactive DFGin 6.2632 13.4746 BLAminus -124.02, 171.64 60.38, 93.51 -113.45, 31.35 303.9, 98.44 -64.25, -25.91 in-in in 8.4947 Saltbr-in 2.8343 HRD-in -79.85, -57.22 94.02, -30.37 in-in-out SNCiio in-out ActLoopNT-in 2.9886 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -116.08, 168.2 APE9-dihe-na -93.6, -119.04 APE8-dihe-in -73.92, 129.61 APE8-rot-in 321.09 APE67-dihe-in -55.49, -37.68 -79.71, 0.19 APE12-dist-in 7.8013 APE11-dist-in 9.5024 APE10-dist-in 7.3888 APE9-dist-out 8.9426 F270Y None None XRAY 2.65 0.195 0.225 A 405.0 395.0 0 29 29 0 [[92, 354]] 1.0 6p5m Homo sapiens AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 6P5MB O75116 18 417 1388.0 O1S:62500 Type1 Inactive DFGin 6.2513 13.6437 BLAminus -124.65, 169.29 60.65, 93.77 -114.08, 30.09 303.05, 96.36 -58.22, -30.22 in-in in 8.643 Saltbr-in 2.8309 HRD-in -79.09, -57.01 92.03, -28.0 in-in-out SNCiio in-out ActLoopNT-in 2.9838 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiio APE10-dihe-na -109.09, 158.86 APE9-dihe-na -92.72, -122.33 APE8-dihe-in -76.3, 130.79 APE8-rot-out 86.08 APE67-dihe-in -53.57, -38.7 -80.54, 4.1 APE12-dist-out 6.637 APE11-dist-in 9.2605 APE10-dist-in 7.384 APE9-dist-out 9.0942 F270Y None None XRAY 2.65 0.195 0.225 B 405.0 387.0 0 29 29 0 [[92, 354]] 1.0 6p5m Homo sapiens AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 8X8XB O75116 29 417 1388.0 YDW:501 Type1 Inactive DFGin 6.4728 13.5414 BLAminus -147.7, 178.94 53.55, 85.93 -102.48, 38.62 301.82, 90.81 -61.05, -30.52 in-in in 8.7733 Saltbr-in 2.8799 HRD-in -76.73, -58.01 80.73, -14.45 in-in-out SNCiio in-out ActLoopNT-in 3.0423 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiio APE10-dihe-na -122.98, 163.07 APE9-dihe-na -99.31, -128.88 APE8-dihe-in -61.96, 135.88 APE8-rot-out 70.76 APE67-dihe-in -50.09, -36.4 -79.46, -6.55 APE12-dist-out 6.7308 APE11-dist-in 8.3441 APE10-dist-in 6.7439 APE9-dist-out 9.3326 None None None XRAY 2.6 0.201 0.253 B 391.0 374.0 9 29 20 9 [[92, 354]] 1.0 8x8x Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 8X8YA O75116 31 417 1388.0 YEA:501 Type1 Inactive DFGin 6.1307 13.1234 BLAminus -148.21, -169.14 44.6, 71.48 -91.3, 16.21 306.78, 89.53 -42.97, -27.25 in-in in 8.4017 Saltbr-in 2.8276 HRD-out -91.42, 96.9 -78.93, 1.22 in-in-out SNCiio in-out ActLoopNT-in 2.9643 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.94, 153.9 APE9-dihe-na 130.12, -144.45 APE8-dihe-in -138.71, 148.43 APE8-rot-out 78.56 APE67-dihe-in -57.28, -22.24 -69.59, -38.91 APE12-dist-in 10.8544 APE11-dist-in 11.8292 APE10-dist-in 5.9972 APE9-dist-in 4.0519 None None None XRAY 3.2 0.185 0.243 A 391.0 378.0 0 29 29 0 [[92, 354]] 1.0 8x8y Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7JOVA O75116 25 417 1388.0 VFS:502 Type1 Inactive DFGin 6.2465 13.2928 BLAminus -141.83, 172.55 62.54, 72.12 -93.6, 17.75 301.11, 105.91 -60.63, -17.81 in-in in 8.505 Saltbr-in 2.6448 HRD-in -61.37, -48.09 70.0, -5.6 in-in-out SNCiio in-out ActLoopNT-in 3.1039 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.41 APE8-rot-out 35.63 APE67-dihe-in -72.9, -30.33 -60.06, -49.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 A 395.0 377.0 12 29 23 6 [[92, 354]] 1.0 7jov Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7JOVC O75116 23 417 1388.0 VFS:501 Type1 Inactive DFGin 6.2684 13.2283 BLAminus -142.15, 173.25 63.2, 71.86 -94.04, 16.61 301.5, 104.97 -62.04, -13.94 in-in in 8.3763 Saltbr-in 2.7548 HRD-in -63.91, -46.28 70.58, -6.77 in-in-out SNCiio in-out ActLoopNT-in 3.102 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_onno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -148.71 APE8-dihe-in -13.99, 103.33 APE8-rot-out 49.66 APE67-dihe-in -50.5, -34.0 -98.95, 10.78 APE12-dist-out 6.1146 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.4434 None None None XRAY 2.586 0.185 0.217 C 395.0 389.0 3 29 27 2 [[92, 354]] 1.0 7jov Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7JOVF O75116 25 417 1388.0 VFS:502 Type1 Inactive DFGin 6.2536 13.3298 BLAminus -142.21, 173.17 67.59, 68.13 -95.04, 16.84 301.9, 107.53 -61.95, -15.75 in-in in 8.5726 Saltbr-in 2.7159 HRD-in -62.26, -47.83 69.9, -5.26 in-in-out SNCiio in-out ActLoopNT-in 3.0981 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -82.91, 164.49 APE9-dihe-na 87.67, 168.25 APE8-dihe-in -79.05, 142.33 APE8-rot-out 46.7 APE67-dihe-in -72.13, -29.81 -50.42, -43.74 APE12-dist-in 8.1458 APE11-dist-in 11.7085 APE10-dist-in 5.7795 APE9-dist-in 4.2858 None None None XRAY 2.586 0.185 0.217 F 395.0 385.0 4 29 29 0 [[92, 354]] 1.0 7jov Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7JOVG O75116 23 417 1388.0 VFS:501 Type1 Inactive DFGin 6.268 13.2068 BLAminus -141.3, 172.73 62.62, 71.55 -93.79, 17.44 301.31, 106.61 -60.9, -17.27 in-in in 8.3572 Saltbr-in 2.6194 HRD-in -63.54, -47.24 68.64, -6.0 in-in-out SNCiio in-out ActLoopNT-in 3.1285 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_innn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.83 APE8-rot-out 39.24 APE67-dihe-in -74.92, -26.36 -51.82, -46.1 APE12-dist-in 10.1264 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 G 395.0 388.0 3 29 26 3 [[92, 354]] 1.0 7jov Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7JOVH O75116 25 417 1388.0 VFS:501 Type1 Inactive DFGin 6.2783 13.2446 BLAminus -141.88, 173.26 61.58, 72.11 -93.64, 17.43 301.68, 105.86 -61.63, -15.37 in-in in 8.4613 Saltbr-in 2.6636 HRD-in -62.24, -47.57 69.31, -6.43 in-in-out SNCiio in-out ActLoopNT-in 3.1108 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -73.76, 175.86 APE9-dihe-na 74.79, 179.62 APE8-dihe-in -84.69, 144.58 APE8-rot-out 45.29 APE67-dihe-in -73.44, -28.15 -53.28, -43.42 APE12-dist-in 8.553 APE11-dist-in 11.9866 APE10-dist-in 5.9693 APE9-dist-in 4.3451 None None None XRAY 2.586 0.185 0.217 H 395.0 386.0 4 29 29 0 [[92, 354]] 1.0 7jov Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7JNTA O75116 25 417 1388.0 VFA:501 Type1 Inactive DFGin 6.175 13.12 BLAminus -142.97, 170.43 61.47, 81.89 -100.92, 25.83 302.43, 103.03 -66.54, -18.35 in-in in 8.58 Saltbr-in 2.7108 HRD-in -62.06, -54.07 74.24, -0.78 in-in-out SNCiio in-out ActLoopNT-in 2.9951 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 115.83 APE8-rot-out 43.33 APE67-dihe-in -64.51, -30.07 -62.81, -50.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 A 399.0 377.0 12 29 23 6 [[92, 354]] 1.0 7jnt Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7JNTC O75116 23 417 1388.0 VFA:501 Type1 Inactive DFGin 6.1756 13.0954 BLAminus -142.99, 169.96 64.19, 75.58 -96.75, 25.55 303.7, 101.46 -67.43, -15.16 in-in in 8.5271 Saltbr-in 2.7058 HRD-in -63.08, -53.72 74.17, -1.22 in-in-out SNCiio in-out ActLoopNT-in 2.9779 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -147.91 APE8-dihe-in -58.47, 131.63 APE8-rot-out 67.86 APE67-dihe-in -44.06, -35.52 -96.11, -4.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.7755 None None None XRAY 2.214 0.211 0.249 C 399.0 386.0 6 29 25 4 [[92, 354]] 1.0 7jnt Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7JNTF O75116 25 417 1388.0 VFA:501 Type1 Inactive DFGin 6.159 13.2166 BLAminus -143.26, 173.18 61.07, 77.1 -97.98, 23.74 303.85, 102.16 -65.15, -17.6 in-in in 8.72 Saltbr-in 2.6872 HRD-in -62.56, -52.92 74.79, -2.1 in-in-out SNCiio in-out ActLoopNT-in 2.9914 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -119.34, 164.51 APE9-dihe-na 111.51, 140.88 APE8-dihe-in -67.31, 148.28 APE8-rot-out 57.04 APE67-dihe-in -67.65, -28.23 -51.9, -44.63 APE12-dist-in 9.7352 APE11-dist-in 11.3689 APE10-dist-in 5.7501 APE9-dist-in 3.9764 None None None XRAY 2.214 0.211 0.249 F 399.0 385.0 4 29 29 0 [[92, 354]] 1.0 7jnt Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7JNTG O75116 23 417 1388.0 VFA:501 Type1 Inactive DFGin 6.1965 13.0703 BLAminus -143.43, 168.41 64.09, 78.4 -99.56, 26.13 303.07, 104.77 -66.2, -17.95 in-in in 8.6534 Saltbr-in 2.6843 HRD-in -63.78, -53.8 74.38, -0.92 in-in-out SNCiio in-out ActLoopNT-in 2.9912 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_innn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 149.13 APE8-rot-out 59.5 APE67-dihe-in -66.38, -28.99 -52.8, -45.16 APE12-dist-in 10.9468 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 G 399.0 388.0 3 29 26 3 [[92, 354]] 1.0 7jnt Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7JNTH O75116 25 417 1388.0 VFA:501 Type1 Inactive DFGin 6.1825 13.1034 BLAminus -143.87, 172.69 61.19, 80.41 -100.34, 25.34 303.5, 101.89 -66.59, -15.9 in-in in 8.6709 Saltbr-in 2.6568 HRD-in -62.35, -53.45 73.79, -2.54 in-in-out SNCiio in-out ActLoopNT-in 3.0057 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.01, 163.73 APE9-dihe-na 113.76, 141.54 APE8-dihe-in -65.64, 151.02 APE8-rot-out 56.73 APE67-dihe-in -67.63, -28.53 -53.68, -45.01 APE12-dist-in 9.8761 APE11-dist-in 11.5797 APE10-dist-in 5.8796 APE9-dist-in 4.0731 None None None XRAY 2.214 0.211 0.249 H 399.0 386.0 4 29 29 0 [[92, 354]] 1.0 7jnt Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6NA O75116 24 417 1388.0 5YS:501 Type1 Inactive DFGin 5.9603 12.8924 BLAminus -147.52, 173.21 55.09, 95.25 -112.31, 21.69 306.93, 92.98 -47.43, -30.39 in-in in 8.6076 Saltbr-in 2.8602 HRD-in -68.21, -48.5 74.44, -76.91 in-in-out SNCiio in-out ActLoopNT-in 3.1915 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_niio APE10-dihe-na -137.17, 134.7 APE9-dihe-na 66.08, 179.98 APE8-dihe-in -79.2, 152.03 APE8-rot-out 39.36 APE67-dihe-in -55.24, -42.06 -64.41, -46.65 APE12-dist-none 999.0 APE11-dist-in 9.5364 APE10-dist-in 6.7557 APE9-dist-out 7.0612 None None None XRAY 3.0 0.186 0.288 A 399.0 384.0 6 29 26 3 [[92, 354]] 1.0 7p6n Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6NB O75116 25 417 1388.0 5YS:501 Type1 Inactive DFGin 5.9177 12.9079 BLAminus -147.26, 173.64 54.74, 95.37 -112.38, 21.14 305.76, 93.69 -46.34, -30.83 in-in in 8.6582 Saltbr-in 2.8521 HRD-in -68.62, -48.31 74.92, -77.15 in-in-out SNCiio in-out ActLoopNT-in 3.1963 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 152.85 APE8-rot-out 38.72 APE67-dihe-in -58.22, -39.82 -64.87, -46.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 B 399.0 385.0 8 29 25 4 [[92, 354]] 1.0 7p6n Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6ND O75116 25 417 1388.0 5YS:501 Type1 Inactive DFGin 5.9112 12.8869 BLAminus -147.57, 174.08 54.32, 95.38 -112.83, 20.77 305.2, 94.02 -46.7, -30.3 in-in in 8.6465 Saltbr-in 2.8456 HRD-in -68.81, -47.96 75.21, -77.34 in-in-out SNCiio in-out ActLoopNT-in 3.1908 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -138.24, 168.24 APE9-dihe-na 66.25, -164.28 APE8-dihe-in -79.15, 151.39 APE8-rot-out 38.92 APE67-dihe-in -57.2, -39.94 -65.63, -47.15 APE12-dist-in 12.8721 APE11-dist-in 11.2239 APE10-dist-in 6.1189 APE9-dist-out 7.0124 None None None XRAY 3.0 0.186 0.288 D 399.0 385.0 4 29 29 0 [[92, 354]] 1.0 7p6n Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6NF O75116 25 417 1388.0 5YS:501 Type1 Inactive DFGin 5.9261 12.9235 BLAminus -146.77, 174.8 54.66, 94.69 -112.86, 21.29 304.94, 93.72 -46.03, -30.46 in-in in 8.6588 Saltbr-in 2.8458 HRD-in -68.6, -48.35 74.88, -77.16 in-in-out SNCiio in-out ActLoopNT-in 3.1986 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -139.14, 168.92 APE9-dihe-na 66.99, -163.85 APE8-dihe-in -78.8, 151.2 APE8-rot-out 38.36 APE67-dihe-in -57.1, -40.42 -65.28, -46.28 APE12-dist-in 11.5866 APE11-dist-in 11.279 APE10-dist-in 6.1627 APE9-dist-out 7.029 None None None XRAY 3.0 0.186 0.288 F 399.0 384.0 5 29 29 0 [[92, 354]] 1.0 7p6n Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6NG O75116 25 417 1388.0 5YS:501 Type1 Inactive DFGin 5.9599 12.8721 BLAminus -147.02, 173.65 54.4, 95.21 -112.65, 21.16 306.2, 93.32 -46.85, -30.81 in-in in 8.6136 Saltbr-in 2.8449 HRD-in -68.3, -48.58 74.65, -77.07 in-in-out SNCiio in-out ActLoopNT-in 3.1927 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 153.91 APE8-rot-out 38.81 APE67-dihe-in -55.86, -41.48 -64.55, -46.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 G 399.0 385.0 4 29 25 4 [[92, 354]] 1.0 7p6n Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6OA O75116 24 417 1388.0 5YK:501 Type1 Inactive DFGin 6.0154 13.121 BLAminus -129.99, 173.74 63.69, 84.38 -107.33, 35.64 304.65, 101.12 -72.03, -45.78 in-in in 8.633 Saltbr-in 2.7576 HRD-in -67.26, -41.63 68.26, 2.18 in-in-out SNCiio in-out ActLoopNT-in 3.2221 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -114.07, 159.24 APE9-dihe-na -78.74, -160.5 APE8-dihe-in -69.68, 142.93 APE8-rot-out 53.5 APE67-dihe-in -55.96, -37.76 -73.63, -19.8 APE12-dist-in 10.3281 APE11-dist-out 7.6374 APE10-dist-out 8.5783 APE9-dist-in 5.5052 None None None XRAY 2.75 0.241 0.286 A 399.0 388.0 2 29 27 2 [[92, 354]] 1.0 7p6o Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6OB O75116 25 417 1388.0 5YK:501 Type1 Inactive DFGin 6.03 13.1172 BLAminus -130.02, 173.83 63.76, 84.52 -107.31, 35.45 304.31, 101.62 -71.82, -45.98 in-in in 8.6543 Saltbr-in 2.7589 HRD-in -67.3, -41.49 68.16, 2.38 in-in-out SNCiio in-out ActLoopNT-in 3.2198 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 142.81 APE8-rot-out 53.14 APE67-dihe-in -56.68, -36.81 -74.24, -19.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 B 399.0 379.0 12 29 22 7 [[92, 354]] 1.0 7p6o Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6OD O75116 25 417 1388.0 5YK:501 Type1 Inactive DFGin 6.0295 13.1154 BLAminus -130.14, 174.07 63.77, 84.08 -107.41, 35.57 304.55, 101.36 -72.14, -45.87 in-in in 8.6845 Saltbr-in 2.7583 HRD-in -67.39, -41.46 68.03, 2.41 in-in-out SNCiio in-out ActLoopNT-in 3.2201 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_inii APE10-dihe-na 999.0, 157.1 APE9-dihe-na 77.73, 175.48 APE8-dihe-in -69.48, 142.35 APE8-rot-out 52.81 APE67-dihe-in -56.84, -36.56 -74.86, -19.55 APE12-dist-in 9.4752 APE11-dist-none 999.0 APE10-dist-in 5.3825 APE9-dist-in 5.499 None None None XRAY 2.75 0.241 0.286 D 399.0 384.0 5 29 28 1 [[92, 354]] 1.0 7p6o Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6OE O75116 25 417 1388.0 5YK:501 Type1 Inactive DFGin 6.0376 13.1036 BLAminus -130.06, 173.52 64.1, 84.65 -107.82, 35.44 304.2, 101.68 -73.02, -45.03 in-in in 8.6513 Saltbr-in 2.7586 HRD-in -67.66, -41.03 68.51, 2.53 in-in-out SNCiio in-out ActLoopNT-in 3.2252 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.09 APE8-rot-out 52.96 APE67-dihe-in -55.98, -37.45 -73.98, -19.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 E 399.0 385.0 5 29 24 5 [[92, 354]] 1.0 7p6o Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6OF O75116 25 417 1388.0 5YK:501 Type1 Inactive DFGin 6.0289 13.1241 BLAminus -130.14, 174.06 63.83, 84.14 -107.45, 35.57 304.61, 101.55 -72.27, -45.71 in-in in 8.6797 Saltbr-in 2.7572 HRD-in -67.35, -41.53 67.92, 2.62 in-in-out SNCiio in-out ActLoopNT-in 3.2207 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.42, 157.65 APE9-dihe-na 77.78, 174.44 APE8-dihe-in -69.32, 142.43 APE8-rot-out 52.91 APE67-dihe-in -56.82, -36.56 -74.83, -19.59 APE12-dist-in 11.2408 APE11-dist-in 10.6912 APE10-dist-in 5.3659 APE9-dist-in 5.4727 None None None XRAY 2.75 0.241 0.286 F 399.0 383.0 6 29 28 1 [[92, 354]] 1.0 7p6o Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6PA O75116 24 417 1388.0 5YV:501 Type1 Inactive DFGin 6.1436 13.4975 BLAminus -132.07, 172.67 54.56, 93.15 -112.26, 31.75 305.01, 96.0 -65.02, -28.17 in-in in 8.9359 Saltbr-in 2.7077 HRD-in -75.76, -48.68 68.71, 2.45 in-in-out SNCiio in-out ActLoopNT-in 3.0199 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_onoo APE10-dihe-na 999.0, -37.69 APE9-dihe-na 68.06, 165.75 APE8-dihe-out 49.49, 69.05 APE8-rot-out 51.42 APE67-dihe-in -43.22, -41.5 -67.31, -24.58 APE12-dist-out 5.8964 APE11-dist-none 999.0 APE10-dist-out 8.8145 APE9-dist-out 9.313 None None None XRAY 2.82 0.222 0.258 A 399.0 389.0 1 29 28 1 [[92, 354]] 1.0 7p6p Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6PB O75116 24 417 1388.0 5YV:501 Type1 Inactive DFGin 6.1537 13.387 BLAminus -129.93, 173.86 61.04, 88.71 -108.06, 31.11 304.98, 97.36 -66.26, -28.42 in-in in 8.705 Saltbr-in 3.1205 HRD-in -76.63, -48.03 68.67, 4.31 in-in-out SNCiio in-out ActLoopNT-in 3.0234 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.26 APE8-rot-out 47.95 APE67-dihe-in -44.6, -41.1 -70.73, -25.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.82 0.222 0.258 B 399.0 374.0 15 29 17 12 [[92, 354]] 1.0 7p6p Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6PC O75116 24 417 1388.0 5YV:501 Type1 Inactive DFGin 6.183 13.4382 BLAminus -129.72, 174.14 60.9, 87.88 -108.85, 31.32 304.91, 96.4 -66.49, -26.92 in-in in 8.7175 Saltbr-in 3.1215 HRD-in -77.5, -47.77 68.57, 3.01 in-in-out SNCiio in-out ActLoopNT-in 3.0284 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.51 APE8-rot-out 47.87 APE67-dihe-in -49.24, -39.17 -68.89, -25.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.82 0.222 0.258 C 399.0 378.0 12 29 18 11 [[92, 354]] 1.0 7p6p Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6PD O75116 24 417 1388.0 5YV:501 Type1 Inactive DFGin 6.1385 13.3878 BLAminus -129.14, 174.38 61.55, 87.6 -108.19, 31.9 304.73, 96.8 -65.3, -27.92 in-in in 8.7545 Saltbr-in 3.1392 HRD-in -76.81, -47.84 67.84, 3.94 in-in-out SNCiio in-out ActLoopNT-in 3.0286 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.04, 138.37 APE9-dihe-na 76.18, 149.98 APE8-dihe-in -41.73, 133.73 APE8-rot-out 47.62 APE67-dihe-in -47.73, -39.5 -71.48, -25.27 APE12-dist-in 11.0305 APE11-dist-in 11.225 APE10-dist-in 6.1393 APE9-dist-in 5.154 None None None XRAY 2.82 0.222 0.258 D 399.0 383.0 6 29 27 2 [[92, 354]] 1.0 7p6p Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6QA O75116 24 417 1388.0 5YO:501 Type1 Inactive DFGin 6.3544 13.3521 BLAminus -144.62, 167.8 60.55, 87.07 -103.28, 32.93 301.59, 102.75 -70.91, -20.49 in-in in 8.6243 Saltbr-in 2.7039 HRD-in -68.26, -48.48 72.01, -4.52 in-in-out SNCiio in-out ActLoopNT-in 2.994 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.2 APE8-rot-out 61.47 APE67-dihe-in -43.02, -40.39 -80.11, -25.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.89 0.209 0.266 A 399.0 377.0 13 29 17 12 [[92, 354]] 1.0 7p6q Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6QB O75116 24 417 1388.0 5YO:501 Type1 Inactive DFGin 6.3 13.3089 BLAminus -144.44, 167.29 60.61, 86.93 -103.67, 32.19 301.37, 101.58 -69.29, -21.55 in-in in 8.6066 Saltbr-in 2.913 HRD-in -66.9, -49.14 71.14, -2.98 in-in-out SNCiio in-out ActLoopNT-in 2.9639 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 125.87 APE8-rot-out 59.05 APE67-dihe-in -44.93, -40.33 -80.35, -26.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.89 0.209 0.266 B 399.0 374.0 15 29 17 12 [[92, 354]] 1.0 7p6q Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6QC O75116 24 417 1388.0 5YO:501 Type1 Inactive DFGin 6.2846 13.3478 BLAminus -141.89, 172.56 57.11, 86.76 -103.5, 32.32 300.6, 102.23 -70.12, -20.17 in-in in 8.6371 Saltbr-in 2.9166 HRD-in -68.26, -48.37 71.29, -4.5 in-in-out SNCiio in-out ActLoopNT-in 2.9721 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnio APE10-dihe-na 999.0, 162.63 APE9-dihe-na 97.71, -154.08 APE8-dihe-in -75.95, 125.62 APE8-rot-out 63.5 APE67-dihe-in -42.44, -40.72 -78.86, -26.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.9414 APE9-dist-out 7.9957 None None None XRAY 2.89 0.209 0.266 C 399.0 387.0 2 29 27 2 [[92, 354]] 1.0 7p6q Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6QD O75116 24 417 1388.0 5YO:501 Type1 Inactive DFGin 6.282 13.2775 BLAminus -144.35, 168.09 60.51, 86.98 -102.62, 32.26 301.67, 102.33 -72.56, -19.6 in-in in 8.6255 Saltbr-in 2.9146 HRD-in -67.92, -48.44 71.11, -3.01 in-in-out SNCiio in-out ActLoopNT-in 2.9762 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -97.55, 159.64 APE9-dihe-na 118.49, 149.2 APE8-dihe-in -71.69, 137.89 APE8-rot-out 54.73 APE67-dihe-in -45.23, -39.33 -77.36, -30.49 APE12-dist-in 12.6103 APE11-dist-in 11.4713 APE10-dist-in 5.7837 APE9-dist-in 5.2067 None None None XRAY 2.89 0.209 0.266 D 399.0 383.0 6 29 27 2 [[92, 354]] 1.0 7p6q Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 9EP8A O75116 22 417 1388.0 A1H6L:60501 Type1 Inactive DFGin 6.4927 13.4745 BLAminus -142.27, 178.16 56.28, 74.06 -91.93, 27.01 300.49, 98.73 -80.86, -4.32 in-in in 8.4189 Saltbr-in 2.607 HRD-in -71.36, -50.57 66.41, 13.03 in-in-out SNCiio in-out ActLoopNT-in 3.2177 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -143.44, 141.63 APE9-dihe-na -72.89, -103.54 APE8-dihe-in -98.04, 136.1 APE8-rot-out 54.66 APE67-dihe-in -51.08, -38.13 -83.55, -17.15 APE12-dist-in 8.7803 APE11-dist-in 8.9625 APE10-dist-out 9.2237 APE9-dist-out 8.8182 None None None XRAY 2.63 0.203 0.242 A 402.0 388.0 2 29 27 2 [[92, 354]] 1.0 9ep8 Homo sapiens AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 9EP8B O75116 24 417 1388.0 A1H6L:60501 Type1 Inactive DFGin 6.7218 13.6046 BLAminus -148.7, 178.5 52.93, 72.5 -93.23, 28.49 302.13, 99.55 -80.04, -2.24 in-in in 8.3809 Saltbr-in 2.629 HRD-in -69.68, -48.04 67.21, 12.72 in-in-out SNCiio in-out ActLoopNT-in 3.2414 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.96 APE8-rot-out 55.95 APE67-dihe-in -50.85, -37.73 -82.2, -18.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.63 0.203 0.242 B 402.0 373.0 16 29 17 12 [[92, 354]] 1.0 9ep8 Homo sapiens AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 9EP8C O75116 24 417 1388.0 A1H6L:60501 Type1 Inactive DFGin 6.7875 13.6967 BLAminus -142.98, 175.13 56.66, 74.33 -94.91, 33.23 302.61, 100.99 -80.72, -3.65 in-in in 8.3304 Saltbr-in 2.6284 HRD-in -69.86, -50.69 67.71, 13.64 in-in-out SNCiio in-out ActLoopNT-in 3.2481 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.91 APE8-rot-out 55.45 APE67-dihe-in -48.54, -38.52 -80.78, -17.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.63 0.203 0.242 C 402.0 375.0 15 29 17 12 [[92, 354]] 1.0 9ep8 Homo sapiens AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 9EP8D O75116 22 417 1388.0 A1H6L:60501 Type1 Inactive DFGin 6.533 13.5154 BLAminus -145.65, 177.68 55.35, 73.4 -93.14, 26.37 302.82, 99.26 -82.32, -4.28 in-in in 8.4987 Saltbr-in 2.6122 HRD-in -71.04, -48.63 67.32, 7.83 in-in-out SNCiio in-out ActLoopNT-in 3.2521 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -134.28, 155.4 APE9-dihe-na -71.41, -102.58 APE8-dihe-in -87.31, 137.03 APE8-rot-out 55.19 APE67-dihe-in -49.79, -38.66 -81.91, -22.13 APE12-dist-in 8.0012 APE11-dist-in 8.6831 APE10-dist-out 8.1259 APE9-dist-out 6.719 None None None XRAY 2.63 0.203 0.242 D 402.0 386.0 5 29 27 2 [[92, 354]] 1.0 9ep8 Homo sapiens AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6OG O75116 25 417 1388.0 5YK:501 Type1.5_Front Inactive DFGin 6.0297 13.0932 BLAminus -130.18, 173.76 63.87, 84.33 -107.4, 35.32 304.41, 101.68 -72.33, -45.62 in-in in 8.6573 Saltbr-in 2.7572 HRD-in -67.47, -41.36 68.16, 2.55 in-in-out SNCiio in-out ActLoopNT-in 3.2227 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.09 APE8-rot-out 52.99 APE67-dihe-in -56.93, -36.54 -73.99, -19.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 G 399.0 381.0 8 29 24 5 [[92, 354]] 1.0 7p6o Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 6ED6B O75116 28 416 1388.0 J0P:501 Type1.5_Front Inactive DFGin 6.3994 13.1828 BLAminus -141.53, 178.3 54.07, 109.38 -133.99, 38.6 302.74, 88.83 -73.72, -23.58 in-in in 8.5374 Saltbr-in 2.8145 HRD-in -63.89, -44.38 75.08, -45.12 in-in-out SNCiio in-out ActLoopNT-in 3.5735 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -112.55 APE8-dihe-in -56.82, 118.75 APE8-rot-in 295.99 APE67-dihe-in -40.0, -36.43 -89.99, -12.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.0585 None None None XRAY 2.86 0.206 0.247 B 415.0 364.0 18 29 17 12 [[92, 354]] 1.0 6ed6 Homo sapiens AGC_ROCK2_HUMAN AGC 2.6e-93 317.9 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 5U7RD O75116 25 417 1388.0 81G:500 Type1 Inactive DFGin 5.9914 13.6381 None -137.02, -44.53 -96.66, 83.52 -88.69, 16.85 303.92, 107.42 -55.18, -36.04 in-in in 8.7331 Saltbr-in 2.7396 HRD-in -81.59, -27.48 68.65, -73.51 in-in-out SNCiio in-out ActLoopNT-in 3.0332 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_onno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -137.68 APE8-dihe-in -113.15, 136.27 APE8-rot-out 64.84 APE67-dihe-in -28.57, -52.13 -70.74, -29.02 APE12-dist-out 6.8435 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.7119 None None None XRAY 3.33 0.202 0.241 D 395.0 382.0 5 29 27 2 [[92, 354]] 1.0 5u7r Homo sapiens AGC_ROCK2_HUMAN AGC 1.7e-93 318.5 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 9JCUA O75116 27 417 1388.0 No_ligand No_ligand Inactive DFGout 15.3055 9.6194 BBAminus -122.68, 142.57 -93.88, 117.42 -92.58, 35.45 292.89, 171.91 87.13, 16.18 out-out out 14.6226 Saltbr-out 18.4867 HRD-in -80.95, -50.27 68.09, 7.79 out-in-out SNCoio in-out ActLoopNT-in 2.9616 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -127.11, 146.68 APE9-dihe-na -74.38, -64.25 APE8-dihe-in -92.78, 136.35 APE8-rot-out 52.4 APE67-dihe-in -50.05, -29.64 -108.42, 7.1 APE12-dist-in 7.3992 APE11-dist-in 9.3327 APE10-dist-in 7.2967 APE9-dist-out 9.3663 None None None XRAY 3.02 0.186 0.22 A 391.0 389.0 0 29 29 0 [[92, 354]] 1.0 9jcu Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 9JCUC O75116 27 417 1388.0 No_ligand No_ligand Inactive DFGout 15.2712 9.7649 BBAminus -106.39, 150.48 -108.17, 107.09 -89.63, 40.89 296.67, 171.34 75.24, 36.56 out-out out 14.7527 Saltbr-out 15.8781 HRD-in -75.77, -43.93 77.36, -10.14 out-in-out SNCoio in-out ActLoopNT-in 2.9219 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.94, 167.95 APE9-dihe-na 94.03, 133.64 APE8-dihe-in -78.46, 149.57 APE8-rot-out 190.58 APE67-dihe-in -65.59, -41.68 -57.26, -43.03 APE12-dist-in 9.7658 APE11-dist-in 11.57 APE10-dist-in 5.7724 APE9-dist-in 4.1616 None None None XRAY 3.02 0.186 0.22 C 391.0 389.0 0 29 29 0 [[92, 354]] 1.0 9jcu Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 8GDSA O75116 24 417 1388.0 Z8O:501 Type1 Inactive DFGout 14.304 9.3951 BBAminus -113.16, 143.54 -102.55, 117.32 -102.58, 29.06 302.77, 145.94 110.64, 5.22 out-out out 15.0791 Saltbr-out 13.9655 HRD-in -62.18, -48.44 83.82, -31.03 out-in-out SNCoio in-out ActLoopNT-in 2.8932 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -67.31, -53.4 APE9-dihe-na 75.32, -130.78 APE8-dihe-in -73.21, 128.78 APE8-rot-in 285.89 APE67-dihe-in -37.36, -36.42 -96.83, -9.21 APE12-dist-none 999.0 APE11-dist-out 7.2565 APE10-dist-out 9.8509 APE9-dist-out 9.4071 None None None XRAY 2.71 0.218 0.248 A 396.0 384.0 6 29 27 2 [[92, 354]] 1.0 8gds Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 8GDSB O75116 24 417 1388.0 Z8O:501 Type1 Inactive DFGout 14.3904 9.5098 BBAminus -111.96, 142.39 -102.56, 118.41 -101.87, 25.6 301.02, 146.14 115.08, 0.13 out-none out 14.9022 Saltbr-none 999.0 HRD-in -65.01, -47.29 71.28, -3.57 none-in-out SNCnio in-out ActLoopNT-in 2.8585 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -134.25, 147.87 APE9-dihe-na -136.74, -95.28 APE8-dihe-in -67.87, 115.24 APE8-rot-in 324.97 APE67-dihe-in -41.62, -33.28 -83.99, -16.64 APE12-dist-none 999.0 APE11-dist-out 5.672 APE10-dist-out 9.8535 APE9-dist-out 8.9466 None None None XRAY 2.71 0.218 0.248 B 396.0 384.0 6 29 26 3 [[92, 354]] 1.0 8gds Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 8GDSC O75116 24 417 1388.0 Z8O:501 Type1 Inactive DFGout 14.4465 9.4014 BBAminus -113.01, 140.92 -102.45, 117.72 -102.11, 26.89 300.53, 146.18 115.19, 0.27 out-none out 14.9991 Saltbr-none 999.0 HRD-in -64.56, -46.59 70.99, -5.08 none-in-out SNCnio in-out ActLoopNT-in 2.8871 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -88.19 APE8-dihe-in -78.06, 129.88 APE8-rot-out 60.88 APE67-dihe-in -45.28, -34.19 -66.72, -39.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.4794 None None None XRAY 2.71 0.218 0.248 C 396.0 385.0 5 29 25 4 [[92, 354]] 1.0 8gds Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 8GDSD O75116 24 417 1388.0 Z8O:501 Type1.5_Front Inactive DFGout 14.5096 9.5483 BBAminus -103.86, 141.89 -103.51, 117.86 -102.63, 25.16 306.33, 142.76 108.24, 20.62 out-none out 14.9691 Saltbr-none 999.0 HRD-in -60.5, -48.74 68.07, -4.31 none-in-none SNCnin in-none ActLoopNT-in 2.9124 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 89.84 APE9-dihe-na 170.11, -172.34 APE8-dihe-in -98.69, 124.47 APE8-rot-in 291.85 APE67-dihe-in -51.67, -33.01 -41.58, -52.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.1219 APE9-dist-in 4.5167 None None None XRAY 2.71 0.218 0.248 D 396.0 379.0 10 29 24 5 [[92, 354]] 1.0 8gds Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 9JCUB O75116 27 417 1388.0 No_ligand No_ligand Inactive DFGout 15.0932 9.676 None -123.7, 136.79 -83.22, 129.55 -106.53, 41.2 289.39, 2.91 73.26, 33.5 out-out out 14.2003 Saltbr-out 17.8227 HRD-in -77.91, -44.8 66.92, 1.93 out-in-out SNCoio in-out ActLoopNT-in 3.0397 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -105.29, 171.74 APE9-dihe-na -102.18, -85.42 APE8-dihe-in -169.86, 135.89 APE8-rot-out 176.2 APE67-dihe-in -66.86, -26.38 -54.25, -48.1 APE12-dist-in 8.648 APE11-dist-out 7.5254 APE10-dist-out 9.5573 APE9-dist-in 3.6482 None None None XRAY 3.02 0.186 0.22 B 391.0 389.0 0 29 29 0 [[92, 354]] 1.0 9jcu Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 9JCUD O75116 27 417 1388.0 No_ligand No_ligand Inactive DFGout 15.1891 10.046 None 61.51, -151.7 -108.74, 133.46 -95.46, 35.35 295.16, 171.82 82.43, 18.9 out-out out 14.6445 Saltbr-out 15.482 HRD-in -89.16, -45.56 76.26, -7.28 out-in-out SNCoio in-out ActLoopNT-in 2.9795 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.41, 151.77 APE9-dihe-na 117.7, 163.08 APE8-dihe-in -78.12, 141.11 APE8-rot-out 189.43 APE67-dihe-in -63.04, -33.79 -53.94, -34.75 APE12-dist-in 11.0414 APE11-dist-in 11.5892 APE10-dist-in 5.9519 APE9-dist-in 4.4577 None None None XRAY 3.02 0.186 0.22 D 391.0 387.0 0 29 29 0 [[92, 354]] 1.0 9jcu Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7JOVB O75116 23 417 1388.0 VFS:501 Type1 None DFGin 6.2716 13.2483 BLAminus -142.1, 173.55 61.9, 71.69 -93.43, 17.34 301.23, 105.57 -59.73, -16.68 in-in in 8.5286 Saltbr-in 2.6299 HRD-in -62.93, -47.02 69.4, -4.67 in-in-none SNCiin in-none ActLoopNT-in 3.0977 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -66.0, -25.51 999.0, -48.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 B 395.0 378.0 11 29 21 8 [[92, 354]] 1.0 7jov Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7JOVD O75116 25 417 1388.0 VFS:501 Type1 None DFGin 6.2428 13.3572 BLAminus -142.23, 173.1 61.78, 71.13 -91.99, 20.3 301.3, 105.37 -69.47, 5.8 in-in in 8.6714 Saltbr-in 2.7008 HRD-in -54.87, -50.75 69.64, -5.46 in-in-none SNCiin in-none ActLoopNT-in 3.1806 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -32.28 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 D 395.0 361.0 26 29 14 15 [[92, 354]] 1.0 7jov Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7JOVE O75116 23 417 1388.0 VFS:501 Type1 None DFGin 6.2985 13.2567 BLAminus -140.47, 172.73 62.89, 72.53 -94.4, 16.26 301.6, 106.26 -62.28, -16.19 in-in in 8.4545 Saltbr-in 2.7399 HRD-in -64.4, -46.2 69.9, -8.61 in-in-none SNCiin in-none ActLoopNT-in 3.1263 ActLoopCT-none nonTYR APEdihe_aanii APEdist_innn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.7 APE8-rot-in 314.77 APE67-dihe-in -47.56, -31.02 -61.45, -35.46 APE12-dist-in 8.281 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 E 395.0 385.0 4 29 26 3 [[92, 354]] 1.0 7jov Homo sapiens AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7JNTB O75116 23 417 1388.0 VFA:501 Type1 None DFGin 6.1649 13.1214 BLAminus -141.64, 172.76 58.92, 82.45 -101.4, 24.85 302.94, 103.08 -64.88, -17.44 in-in in 8.6979 Saltbr-in 2.7387 HRD-in -62.47, -54.27 74.29, -0.05 in-in-none SNCiin in-none ActLoopNT-in 2.9957 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -59.99, -27.47 999.0, -54.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 B 399.0 376.0 13 29 21 8 [[92, 354]] 1.0 7jnt Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7JNTD O75116 25 417 1388.0 VFA:501 Type1 None DFGin 6.1586 13.1604 BLAminus -143.53, 169.89 61.25, 83.67 -103.29, 25.02 302.97, 101.79 -66.66, -17.12 in-in in 8.7301 Saltbr-in 2.7399 HRD-in -61.61, -54.54 74.16, -0.65 in-in-none SNCiin in-none ActLoopNT-in 2.9935 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -35.7 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 D 399.0 360.0 27 29 14 15 [[92, 354]] 1.0 7jnt Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7JNTE O75116 23 417 1388.0 VFA:501 Type1 None DFGin 6.2142 13.058 BLAminus -142.23, 169.06 60.85, 86.77 -104.6, 25.19 302.23, 103.83 -66.31, -19.22 in-in in 8.5732 Saltbr-in 2.6677 HRD-in -56.89, -52.9 74.38, -3.32 in-in-none SNCiin in-none ActLoopNT-in 3.0436 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 73.83 APE8-rot-in 306.93 APE67-dihe-in -51.63, -28.56 -78.96, -16.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 E 399.0 384.0 5 29 25 4 [[92, 354]] 1.0 7jnt Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6NC O75116 23 417 1388.0 5YS:501 Type1 None DFGin 5.9336 12.9198 BLAminus -146.55, 173.64 55.03, 95.19 -112.85, 21.67 306.28, 93.38 -46.66, -30.29 in-in in 8.6716 Saltbr-in 2.8448 HRD-in -68.54, -48.47 75.35, -77.76 in-in-none SNCiin in-none ActLoopNT-in 3.1882 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -54.16, -41.45 999.0, -46.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 C 399.0 378.0 12 29 23 6 [[92, 354]] 1.0 7p6n Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6NE O75116 23 417 1388.0 5YS:501 Type1 None DFGin 5.9547 12.8666 BLAminus -145.98, 174.14 54.43, 95.4 -112.52, 20.29 306.04, 93.17 -47.1, -30.89 in-in in 8.6001 Saltbr-in 2.8492 HRD-in -68.77, -48.13 75.51, -77.25 in-in-none SNCiin in-none ActLoopNT-in 3.1937 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -55.16, -41.37 999.0, -45.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 E 399.0 385.0 6 29 23 6 [[92, 354]] 1.0 7p6n Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6NH O75116 25 417 1388.0 5YS:501 Type1 None DFGin 5.9239 12.9869 BLAminus -147.12, 173.74 54.77, 95.23 -112.35, 21.15 305.58, 93.62 -44.02, -31.78 in-in in 8.7536 Saltbr-in 2.8397 HRD-in -68.48, -48.35 74.56, -77.19 in-in-none SNCiin in-none ActLoopNT-in 3.1944 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.65, -39.86 999.0, -45.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 H 399.0 366.0 23 29 14 15 [[92, 354]] 1.0 7p6n Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6OC O75116 22 417 1388.0 5YK:501 Type1.5_Front None DFGin 6.0199 13.0977 BLAminus -129.77, 174.02 63.85, 83.94 -107.22, 35.66 304.43, 101.43 -71.69, -46.2 in-in in 8.6693 Saltbr-in 2.758 HRD-in -67.24, -41.54 67.86, 2.47 in-in-none SNCiin in-none ActLoopNT-in 3.2217 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.0, -37.44 999.0, -18.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 C 399.0 377.0 13 29 22 7 [[92, 354]] 1.0 7p6o Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_HUMAN 7P6OH O75116 24 417 1388.0 5YK:501 Type1.5_Front None DFGin 6.0306 13.1422 BLAminus -130.18, 173.86 63.9, 84.23 -107.39, 35.65 304.66, 101.19 -71.86, -45.96 in-in in 8.6848 Saltbr-in 2.7574 HRD-in -67.2, -41.51 67.93, 2.34 in-in-none SNCiin in-none ActLoopNT-in 3.2184 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.17, -36.5 999.0, -17.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 H 399.0 369.0 19 29 15 14 [[92, 354]] 1.0 7p6o Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2

AGC_ROCK2 (Rho-associated protein kinase 2)

Total number of chains: 3
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 66.7% 2F2UA
DFGin BLAminus 1 33.3% 2F2UB

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ROCK2 ROCK2_BOVIN 2F2UA Q28021 27 417 1388.0 M77:501 Type1 Inactive DFGin 6.1545 13.9643 ABAminus -125.36, 20.74 -155.97, 132.58 -140.63, 28.66 305.18, 93.77 -61.1, -20.63 in-in in 9.2012 Saltbr-in 2.8484 HRD-in -71.0, -56.95 70.45, 14.05 in-in-out SNCiio in-out ActLoopNT-in 3.1004 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.24, 160.08 APE9-dihe-na 106.51, 163.99 APE8-dihe-in -75.45, 135.55 APE8-rot-out 188.78 APE67-dihe-in -58.72, -25.7 -36.99, -50.18 APE12-dist-in 9.876 APE11-dist-in 11.6551 APE10-dist-in 5.7528 APE9-dist-in 3.7744 None None None XRAY 2.4 0.197 0.235 A 402.0 386.0 0 29 29 0 [[92, 354]] 1.0 2f2u Bos taurus AGC_ROCK2_BOVIN AGC 2.6e-93 317.9 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_BOVIN 2H9VA Q28021 25 417 1388.0 Y27:500 Type1 Inactive DFGin 5.8532 13.3743 ABAminus -112.95, -9.44 -122.76, 149.79 -143.58, -5.13 306.08, 85.41 -38.72, -9.58 in-in in 9.2032 Saltbr-in 2.7224 HRD-in -79.43, -50.38 70.18, 0.12 in-in-in SNCiii in-in ActLoopNT-in 2.9979 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.4, 143.53 APE9-dihe-na 126.28, -170.44 APE8-dihe-in -95.31, 128.27 APE8-rot-in 291.56 APE67-dihe-in -48.07, -17.55 -32.2, -61.95 APE12-dist-in 10.1405 APE11-dist-in 11.4795 APE10-dist-in 5.8196 APE9-dist-in 4.2608 None None None XRAY 3.1 0.234 0.277 A 402.0 383.0 0 29 29 0 [[92, 354]] 1.0 2h9v Bos taurus AGC_ROCK2_BOVIN AGC 2.6e-93 317.9 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
ROCK2 ROCK2_BOVIN 2F2UB Q28021 27 417 1388.0 M77:1501 Type1 Inactive DFGin 6.1606 13.2523 BLAminus -137.47, 174.34 55.62, 88.13 -108.95, 28.93 305.37, 102.14 -67.94, -16.5 in-in in 8.3564 Saltbr-in 3.0307 HRD-in -77.45, -48.84 68.99, 13.39 in-in-out SNCiio in-out ActLoopNT-in 2.9443 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -93.52, 138.42 APE9-dihe-na -106.28, -104.32 APE8-dihe-in -64.29, 128.15 APE8-rot-in 304.0 APE67-dihe-in -52.28, -37.75 -95.33, 10.69 APE12-dist-out 5.1639 APE11-dist-in 9.6251 APE10-dist-out 10.1166 APE9-dist-out 9.097 None None None XRAY 2.4 0.197 0.235 B 402.0 383.0 0 29 29 0 [[92, 354]] 1.0 2f2u Bos taurus AGC_ROCK2_BOVIN AGC 2.6e-93 317.9 1.0 260.0 260.0 231 232 233 235 237 121 140 144 211 213 212 214.0 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2