TKL_RIPK3 (Receptor-interacting serine/threonine-protein kinase 3)

Total number of chains: 9
Active chains: 2
Family: TKL
Uniprot: RIPK3_HUMAN
Kinase Domain Residues: 21 - 285
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 66.7% AF-Q9Y572-K1A
DFGin BLBplus 3 33.3% 9LFUB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q9Y572-K1A 13 293 518.0 No_ligand No_ligand Active DFGin 6.184 14.107 BLAminus -136.64, 175.02 56.98, 73.57 -88.11, 18.5 298.3, 99.24 -61.96, -29.73 in-in in 8.248 Saltbr-in 2.692 HRD-in -72.03, -44.39 65.31, -2.99 in-in-in SNCiii in-in ActLoopNT-in 3.066 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -86.86, 138.33 APE9-dihe-na 114.87, 169.56 APE8-dihe-in -80.98, 116.64 APE8-rot-in 302.32 APE67-dihe-in -59.85, -33.44 -51.1, -38.34 APE12-dist-in 12.498 APE11-dist-in 11.544 APE10-dist-in 6.931 APE9-dist-in 3.645 None None None AF2 -1.0 1.0 1.0 A 281 281 0 0 0 0 [[21, 285]] 1.0 AF-Q9Y572-K1 TKL_RIPK3_HUMAN TKL 7.5e-66 228.3 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
AF-Q9Y572-K3A 13 293 518.0 No_ligand No_ligand Active DFGin 6.145 14.133 BLAminus -139.86, 178.44 59.43, 59.33 -73.59, 12.29 294.86, 96.09 -62.88, -23.79 in-in in 8.344 Saltbr-in 2.716 HRD-in -76.12, -45.4 67.85, -8.25 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -58.57, 128.0 APE9-dihe-na 142.75, 179.47 APE8-dihe-in -91.29, 123.75 APE8-rot-in 303.6 APE67-dihe-in -72.46, -18.07 -52.04, -36.41 APE12-dist-in 11.865 APE11-dist-in 11.015 APE10-dist-in 6.647 APE9-dist-in 3.7 None None None AF2 -1.0 1.0 1.0 A 281 281 0 0 0 0 [[21, 285]] 1.0 AF-Q9Y572-K3 TKL_RIPK3_HUMAN TKL 7.5e-66 228.3 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
7MX3B 12 309 518.0 ZOV:401 Type1 Inactive DFGin 6.542 14.261 BLAminus -142.24, -163.59 59.46, 56.29 -87.14, 32.54 292.99, 86.32 -63.8, -63.45 in-out in 8.213 Saltbr-out 3.884 HRD-in -71.92, -42.98 73.44, -14.04 out-in-none SNCoin in-none ActLoopNT-in 2.94 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 174.97 APE8-rot-in 306.5 APE67-dihe-in -71.82, -40.75 -58.31, -39.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C3S,C110A None None XRAY 3.23 0.244 0.285 B 319 269 29 0 0 16 [[21, 285]] 1.0 7mx3 TKL_RIPK3_HUMAN TKL 7.4e-66 228.4 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
9LFUA 5 308 518.0 A1D97:401 Type1.5_Back Inactive DFGin 5.996 13.686 BLBplus -135.94, 163.32 62.81, 12.82 -63.97, 140.04 54.41, 91.52 80.44, -7.15 out-out out 16.21 Saltbr-out 17.02 HRD-in -75.3, -56.71 75.7, -2.94 out-out-none SNCoon out-none ActLoopNT-out 6.793 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -51.02 APE8-rot-in 298.84 APE67-dihe-in -66.45, -10.27 -90.56, 12.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C3S,C110A None None XRAY 2.93 0.261 0.319 A 346 284 20 0 0 12 [[21, 285]] 1.0 9lfu TKL_RIPK3_HUMAN TKL 9.8e-66 228.1 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
9LFUB 5 309 518.0 A1D97:401 Type1.5_Back Inactive DFGin 5.807 13.647 BLBplus -133.71, 159.3 64.19, 14.67 -64.66, 136.35 58.15, 93.86 79.55, -9.57 out-out out 16.248 Saltbr-out 17.275 HRD-in -84.97, -58.34 80.02, -12.81 out-out-out SNCooo out-out ActLoopNT-out 6.726 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -86.85 APE8-rot-out 57.93 APE67-dihe-in -57.35, -12.11 -95.41, 2.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C3S,C110A None None XRAY 2.93 0.261 0.319 B 346 286 19 0 0 14 [[21, 285]] 1.0 9lfu TKL_RIPK3_HUMAN TKL 9.8e-66 228.1 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
7MONB 5 311 518.0 ZL1:401 Type1.5_Front Inactive DFGin 5.319 12.898 BLBplus -139.6, 164.18 56.61, 37.55 -80.29, 166.6 34.44, 92.89 79.72, -103.63 out-out out 11.648 Saltbr-out 7.413 HRD-in -76.18, -40.34 61.78, -4.08 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na 97.81, 14.44 APE9-dihe-na -63.58, 158.11 APE8-dihe-out -64.13, -29.56 APE8-rot-in 301.21 APE67-dihe-in -66.2, -17.44 -59.33, -40.24 APE12-dist-out 18.646 APE11-dist-out 21.316 APE10-dist-out 17.042 APE9-dist-out 10.554 C3S,C110A TPO224,SEP227 TPO224,SEP227 XRAY 2.23 0.212 0.26 B 316 285 22 0 0 12 [[21, 285]] 1.0 7mon TKL_RIPK3_HUMAN TKL 7.2e-66 228.4 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
7MX3A 12 314 518.0 ZOV:401 Type1.5_Back None DFGin 6.222 13.909 BLAminus -152.35, -176.12 58.98, 65.68 -88.59, 21.74 285.92, 83.22 -75.2, -29.2 in-in in 7.967 Saltbr-in 2.917 HRD-in -70.69, -48.21 67.95, 8.04 in-in-none SNCiin in-none ActLoopNT-in 3.202 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -69.66, -25.03 999.0, -33.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C3S,C110A None None XRAY 3.23 0.244 0.285 A 319 292 11 0 0 10 [[21, 285]] 1.0 7mx3 TKL_RIPK3_HUMAN TKL 7.4e-66 228.4 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
7MX3C 9 311 518.0 ZOV:401 Type1.5_Back None DFGin 6.324 14.409 BLAminus -144.06, -179.33 56.59, 66.53 -89.63, 30.65 289.6, 92.66 -94.37, -38.42 in-in in 7.368 Saltbr-in 3.19 HRD-in -62.63, -60.0 65.83, 13.04 in-in-none SNCiin in-none ActLoopNT-in 3.154 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.63, -27.61 999.0, -44.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C3S,C110A None None XRAY 3.23 0.244 0.285 C 319 285 18 0 0 10 [[21, 285]] 1.0 7mx3 TKL_RIPK3_HUMAN TKL 7.4e-66 228.4 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
7MX3D 12 311 518.0 ZOV:401 Type1.5_Back None DFGin 6.158 13.934 BLAminus -152.67, -168.91 60.99, 69.08 -93.05, 21.87 286.54, 121.22 -73.96, -39.13 in-in in 8.115 Saltbr-in 3.229 HRD-in -81.46, -31.71 66.32, -56.05 in-in-none SNCiin in-none ActLoopNT-in 2.938 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 153.09 APE8-rot-in 303.22 APE67-dihe-in -61.12, -38.55 -55.88, -51.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C3S,C110A None None XRAY 3.23 0.244 0.285 D 319 280 19 0 0 14 [[21, 285]] 1.0 7mx3 TKL_RIPK3_HUMAN TKL 7.4e-66 228.4 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3

TKL_RIPK3 (Receptor-interacting serine/threonine-protein kinase 3)

Total number of chains: 39
Active chains: 2
Family: TKL
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 24 61.5% AF-Q9Y572-K1A
DFGin BLBplus 5 12.8% 4M69A
DFGin None 5 12.8% 9LFVA
DFGout None 5 12.8% 6OKOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
RIPK3_HUMAN AF-Q9Y572-K1A Q9Y572 13 293 518.0 No_ligand No_ligand Active DFGin 6.184 14.107 BLAminus -136.64, 175.02 56.98, 73.57 -88.11, 18.5 298.3, 99.24 -61.96, -29.73 in-in in 8.248 Saltbr-in 2.692 HRD-in -72.03, -44.39 65.31, -2.99 in-in-in SNCiii in-in ActLoopNT-in 3.066 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -86.86, 138.33 APE9-dihe-na 114.87, 169.56 APE8-dihe-in -80.98, 116.64 APE8-rot-in 302.32 APE67-dihe-in -59.85, -33.44 -51.1, -38.34 APE12-dist-in 12.498 APE11-dist-in 11.544 APE10-dist-in 6.931 APE9-dist-in 3.645 None None None AF2 -1.0 1.0 1.0 A 281 281 0 0 0 0 [[21, 285]] 1.0 AF-Q9Y572-K1 Homo sapiens TKL_RIPK3_HUMAN TKL 7.5e-66 228.3 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_HUMAN AF-Q9Y572-K3A Q9Y572 13 293 518.0 No_ligand No_ligand Active DFGin 6.145 14.133 BLAminus -139.86, 178.44 59.43, 59.33 -73.59, 12.29 294.86, 96.09 -62.88, -23.79 in-in in 8.344 Saltbr-in 2.716 HRD-in -76.12, -45.4 67.85, -8.25 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -58.57, 128.0 APE9-dihe-na 142.75, 179.47 APE8-dihe-in -91.29, 123.75 APE8-rot-in 303.6 APE67-dihe-in -72.46, -18.07 -52.04, -36.41 APE12-dist-in 11.865 APE11-dist-in 11.015 APE10-dist-in 6.647 APE9-dist-in 3.7 None None None AF2 -1.0 1.0 1.0 A 281 281 0 0 0 0 [[21, 285]] 1.0 AF-Q9Y572-K3 Homo sapiens TKL_RIPK3_HUMAN TKL 7.5e-66 228.3 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_HUMAN 7MX3B Q9Y572 12 309 518.0 ZOV:401 Type1 Inactive DFGin 6.542 14.261 BLAminus -142.24, -163.59 59.46, 56.29 -87.14, 32.54 292.99, 86.32 -63.8, -63.45 in-out in 8.213 Saltbr-out 3.884 HRD-in -71.92, -42.98 73.44, -14.04 out-in-none SNCoin in-none ActLoopNT-in 2.94 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 174.97 APE8-rot-in 306.5 APE67-dihe-in -71.82, -40.75 -58.31, -39.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C3S,C110A None None XRAY 3.23 0.244 0.285 B 319 269 29 0 0 16 [[21, 285]] 1.0 7mx3 Homo sapiens TKL_RIPK3_HUMAN TKL 7.4e-66 228.4 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_HUMAN 9LFUA Q9Y572 5 308 518.0 A1D97:401 Type1.5_Back Inactive DFGin 5.996 13.686 BLBplus -135.94, 163.32 62.81, 12.82 -63.97, 140.04 54.41, 91.52 80.44, -7.15 out-out out 16.21 Saltbr-out 17.02 HRD-in -75.3, -56.71 75.7, -2.94 out-out-none SNCoon out-none ActLoopNT-out 6.793 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -51.02 APE8-rot-in 298.84 APE67-dihe-in -66.45, -10.27 -90.56, 12.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C3S,C110A None None XRAY 2.93 0.261 0.319 A 346 284 20 0 0 12 [[21, 285]] 1.0 9lfu Homo sapiens TKL_RIPK3_HUMAN TKL 9.8e-66 228.1 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_HUMAN 9LFUB Q9Y572 5 309 518.0 A1D97:401 Type1.5_Back Inactive DFGin 5.807 13.647 BLBplus -133.71, 159.3 64.19, 14.67 -64.66, 136.35 58.15, 93.86 79.55, -9.57 out-out out 16.248 Saltbr-out 17.275 HRD-in -84.97, -58.34 80.02, -12.81 out-out-out SNCooo out-out ActLoopNT-out 6.726 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -86.85 APE8-rot-out 57.93 APE67-dihe-in -57.35, -12.11 -95.41, 2.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C3S,C110A None None XRAY 2.93 0.261 0.319 B 346 286 19 0 0 14 [[21, 285]] 1.0 9lfu Homo sapiens TKL_RIPK3_HUMAN TKL 9.8e-66 228.1 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_HUMAN 7MONB Q9Y572 5 311 518.0 ZL1:401 Type1.5_Front Inactive DFGin 5.319 12.898 BLBplus -139.6, 164.18 56.61, 37.55 -80.29, 166.6 34.44, 92.89 79.72, -103.63 out-out out 11.648 Saltbr-out 7.413 HRD-in -76.18, -40.34 61.78, -4.08 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na 97.81, 14.44 APE9-dihe-na -63.58, 158.11 APE8-dihe-out -64.13, -29.56 APE8-rot-in 301.21 APE67-dihe-in -66.2, -17.44 -59.33, -40.24 APE12-dist-out 18.646 APE11-dist-out 21.316 APE10-dist-out 17.042 APE9-dist-out 10.554 C3S,C110A TPO224,SEP227 TPO224,SEP227 XRAY 2.23 0.212 0.26 B 316 285 22 0 0 12 [[21, 285]] 1.0 7mon Homo sapiens TKL_RIPK3_HUMAN TKL 7.2e-66 228.4 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_HUMAN 7MX3A Q9Y572 12 314 518.0 ZOV:401 Type1.5_Back None DFGin 6.222 13.909 BLAminus -152.35, -176.12 58.98, 65.68 -88.59, 21.74 285.92, 83.22 -75.2, -29.2 in-in in 7.967 Saltbr-in 2.917 HRD-in -70.69, -48.21 67.95, 8.04 in-in-none SNCiin in-none ActLoopNT-in 3.202 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -69.66, -25.03 999.0, -33.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C3S,C110A None None XRAY 3.23 0.244 0.285 A 319 292 11 0 0 10 [[21, 285]] 1.0 7mx3 Homo sapiens TKL_RIPK3_HUMAN TKL 7.4e-66 228.4 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_HUMAN 7MX3C Q9Y572 9 311 518.0 ZOV:401 Type1.5_Back None DFGin 6.324 14.409 BLAminus -144.06, -179.33 56.59, 66.53 -89.63, 30.65 289.6, 92.66 -94.37, -38.42 in-in in 7.368 Saltbr-in 3.19 HRD-in -62.63, -60.0 65.83, 13.04 in-in-none SNCiin in-none ActLoopNT-in 3.154 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.63, -27.61 999.0, -44.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C3S,C110A None None XRAY 3.23 0.244 0.285 C 319 285 18 0 0 10 [[21, 285]] 1.0 7mx3 Homo sapiens TKL_RIPK3_HUMAN TKL 7.4e-66 228.4 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_HUMAN 7MX3D Q9Y572 12 311 518.0 ZOV:401 Type1.5_Back None DFGin 6.158 13.934 BLAminus -152.67, -168.91 60.99, 69.08 -93.05, 21.87 286.54, 121.22 -73.96, -39.13 in-in in 8.115 Saltbr-in 3.229 HRD-in -81.46, -31.71 66.32, -56.05 in-in-none SNCiin in-none ActLoopNT-in 2.938 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 153.09 APE8-rot-in 303.22 APE67-dihe-in -61.12, -38.55 -55.88, -51.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C3S,C110A None None XRAY 3.23 0.244 0.285 D 319 280 19 0 0 14 [[21, 285]] 1.0 7mx3 Homo sapiens TKL_RIPK3_HUMAN TKL 7.4e-66 228.4 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 4M66A Q9QZL0 15 312 486.0 No_ligand No_ligand Inactive DFGin 6.055 13.859 BLAminus -141.67, 175.97 66.14, 79.95 -103.85, 30.15 301.98, 92.84 -68.28, -27.67 in-in in 8.633 Saltbr-in 2.752 HRD-in -64.88, -51.98 74.08, -8.59 in-in-out SNCiio in-out ActLoopNT-in 2.797 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -54.85 APE8-dihe-out -46.37, -3.77 APE8-rot-out 175.43 APE67-dihe-in -70.4, -20.56 -55.19, -35.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.984 C111A None None XRAY 2.401 0.217 0.258 A 325 268 30 0 0 15 [[20, 290]] 1.0 4m66 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IWYA Q9QZL0 15 311 486.0 A1D97:60401 Type1 Inactive DFGin 7.381 13.315 BLAminus -145.3, 163.78 57.87, 69.65 -81.11, 58.68 314.75, 92.73 105.23, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.94, -45.69 67.4, -3.27 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -54.74 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.52 0.27 0.299 A 325 243 54 0 0 25 [[20, 290]] 1.0 9iwy Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IX1B Q9QZL0 15 313 486.0 PP2:60401 Type1 Inactive DFGin 6.167 14.352 BLAminus -148.46, 177.74 57.68, 87.36 -104.16, 25.73 298.93, 91.95 -67.83, -27.46 in-in in 8.157 Saltbr-in 2.678 HRD-in -72.53, -47.36 68.74, 3.0 in-in-out SNCiio in-out ActLoopNT-in 2.805 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -77.43 APE8-rot-out 57.1 APE67-dihe-in -61.06, -23.36 -77.17, -1.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.31 0.221 0.255 B 325 255 44 0 0 18 [[20, 290]] 1.0 9ix1 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IWWB Q9QZL0 13 313 486.0 A1D96:401 Type1.5_Back Inactive DFGin 5.993 13.551 BLAminus -143.56, 174.68 61.93, 81.26 -97.31, 23.35 302.29, 97.52 -69.97, -24.78 in-in in 8.395 Saltbr-in 2.894 HRD-in -65.13, -51.7 74.4, -3.35 in-in-out SNCiio in-out ActLoopNT-in 2.711 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -147.97, -2.69 APE9-dihe-na -82.83, -170.1 APE8-dihe-in -66.65, 153.26 APE8-rot-out 178.53 APE67-dihe-in -65.76, -22.0 -107.76, 6.47 APE12-dist-out 6.099 APE11-dist-out 7.592 APE10-dist-out 11.249 APE9-dist-out 9.921 None None None XRAY 1.93 0.183 0.209 B 325 274 27 0 0 14 [[20, 290]] 1.0 9iww Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IWZB Q9QZL0 14 313 486.0 ZOV:401 Type1.5_Back Inactive DFGin 5.997 13.305 BLAminus -144.47, 173.55 62.65, 86.08 -102.43, 20.57 300.27, 99.76 -65.16, -25.91 in-in in 8.213 Saltbr-in 2.684 HRD-in -67.11, -51.33 74.52, -2.58 in-in-out SNCiio in-out ActLoopNT-in 2.849 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 2.11 APE9-dihe-na -92.49, -170.4 APE8-dihe-in -66.48, 151.74 APE8-rot-out 179.71 APE67-dihe-in -61.05, -23.54 -107.82, 2.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.509 APE9-dist-out 9.92 None None None XRAY 1.82 0.178 0.211 B 325 271 29 0 0 16 [[20, 290]] 1.0 9iwz Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IWXB Q9QZL0 14 313 486.0 A1D96:401 Type1.5_Back Inactive DFGin 6.375 13.839 BLAminus -141.47, 172.49 62.47, 82.69 -97.63, 22.27 297.98, 86.87 -70.61, -24.89 in-in in 8.39 Saltbr-in 2.907 HRD-in -67.61, -51.07 72.36, -2.33 in-in-out SNCiio in-out ActLoopNT-in 2.806 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 13.18 APE9-dihe-na -80.39, -173.32 APE8-dihe-in -63.1, 154.41 APE8-rot-out 170.77 APE67-dihe-in -64.75, -25.15 -109.43, 9.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.098 APE9-dist-out 9.836 R69H None None XRAY 1.99 0.189 0.236 B 325 270 30 0 0 16 [[20, 290]] 1.0 9iwx Mus musculus TKL_RIPK3_MOUSE TKL 7.7e-60 208.6 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 4M69A Q9QZL0 12 312 486.0 ANP:60401 ATPlike Inactive DFGin 6.32 13.402 BLBplus -137.99, 167.73 62.19, 26.69 -80.85, 141.15 41.42, 94.11 79.17, -4.63 out-out out 16.188 Saltbr-out 16.694 HRD-in -64.86, -72.1 85.35, 0.02 out-out-out SNCooo out-out ActLoopNT-out 6.434 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -38.44, -35.37 APE9-dihe-na -67.82, -39.64 APE8-dihe-out -81.63, -25.9 APE8-rot-out 193.07 APE67-dihe-in -56.22, -29.66 -74.57, -26.5 APE12-dist-out 15.23 APE11-dist-out 16.641 APE10-dist-out 19.236 APE9-dist-out 12.364 None SEP184,TPO231,SEP232 SEP184,TPO231,SEP232 XRAY 2.497 0.222 0.246 A 313 287 14 0 0 14 [[20, 290]] 1.0 4m69 Mus musculus TKL_RIPK3_MOUSE TKL 7.1e-60 208.7 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9LFWA Q9QZL0 5 312 486.0 A1D97:60401 Type1.5_Back Inactive DFGin 6.585 13.126 BLBplus -131.15, 162.08 64.23, 14.69 -67.09, 146.1 51.36, 90.93 77.16, -15.72 out-out out 15.978 Saltbr-out 17.155 HRD-in -70.85, -60.94 79.59, -9.5 out-out-out SNCooo out-out ActLoopNT-out 6.34 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 156.06 APE8-rot-out 186.0 APE67-dihe-in -61.62, -27.57 -97.1, 3.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R69H None None XRAY 1.59 0.204 0.238 A 325 290 18 0 0 18 [[20, 290]] 1.0 9lfw Mus musculus TKL_RIPK3_MOUSE TKL 7.7e-60 208.6 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IWYB Q9QZL0 15 311 486.0 A1D97:60401 Type1 Inactive DFGin 6.968 14.062 None -141.15, 157.34 72.96, -21.93 37.23, 42.97 300.12, 81.7 83.46, 13.22 in-none in 9.108 Saltbr-none 999.0 HRD-in -65.47, -42.38 68.5, -9.87 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -44.45 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.52 0.27 0.299 B 325 249 48 0 0 23 [[20, 290]] 1.0 9iwy Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9LFVB Q9QZL0 14 311 486.0 A1EJP:60401 Type1 Inactive DFGin 7.019 14.076 None -145.36, 167.9 72.34, -50.6 63.07, 38.87 298.34, 85.19 73.03, 11.82 out-out out 13.229 Saltbr-out 11.321 HRD-in -75.72, -32.7 64.15, -13.21 out-out-none SNCoon out-none ActLoopNT-out 11.183 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -75.83, -8.32 999.0, 22.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.78 0.249 0.28 B 325 256 42 0 0 20 [[20, 290]] 1.0 9lfv Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9LFVC Q9QZL0 14 311 486.0 A1EJP:60401 Type1 Inactive DFGin 7.013 13.871 None -142.11, 177.11 62.46, -56.12 66.46, 24.11 299.69, 104.14 92.05, 19.19 out-none out 13.512 Saltbr-none 999.0 HRD-in -83.63, -35.26 71.15, -28.83 none-out-none SNCnon out-none ActLoopNT-out 11.309 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -81.07, -0.33 999.0, 20.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.78 0.249 0.28 C 325 250 48 0 0 21 [[20, 290]] 1.0 9lfv Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9LFVD Q9QZL0 13 311 486.0 A1EJP:60401 Type1 Inactive DFGin 7.065 13.893 None -144.3, 176.32 70.73, -56.46 59.33, 41.69 299.17, 86.38 64.18, 23.93 out-none out 14.401 Saltbr-none 999.0 HRD-in -78.46, -41.38 66.14, 7.65 none-out-none SNCnon out-none ActLoopNT-out 11.261 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.45 APE8-rot-none 999.0 APE67-dihe-in -71.04, -19.34 -115.22, 23.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.78 0.249 0.28 D 325 255 44 0 0 20 [[20, 290]] 1.0 9lfv Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9LFVA Q9QZL0 13 311 486.0 A1EJO:60401,A1EJP:60402 Type1,Type1 Inactive DFGin 7.33 14.14 None -146.0, 165.54 71.61, -51.04 65.28, 34.98 298.07, 86.12 73.14, 14.66 out-none out 13.261 Saltbr-none 999.0 HRD-in -73.78, -36.28 68.29, -16.9 none-out-out SNCnoo out-out ActLoopNT-out 11.387 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 42.16 APE8-dihe-in -76.77, 175.03 APE8-rot-none 999.0 APE67-dihe-in -74.57, -14.2 -136.84, 23.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.066 None None None XRAY 2.78 0.249 0.28 A 325 259 40 0 0 18 [[20, 290]] 1.0 9lfv Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 6OKOA Q9QZL0 14 311 486.0 1FN:4000 Type2 Inactive DFGout 14.657 9.479 None -150.96, 174.92 -144.36, 105.73 -56.39, 999.0 272.32, 88.92 999.0, 999.0 in-in in 8.288 Saltbr-in 2.699 HRD-in -68.52, -53.05 75.17, -14.49 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -55.0 APE8-dihe-out -66.23, -6.09 APE8-rot-out 181.11 APE67-dihe-in -65.76, -28.77 -67.24, -21.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.291 None None None XRAY 2.1 0.181 0.198 A 325 263 35 0 0 23 [[20, 290]] 1.0 6oko Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 6OKOB Q9QZL0 13 311 486.0 1FN:4000 Type2 Inactive DFGout 14.797 9.688 None -145.94, 173.66 -143.61, 99.01 -60.19, 999.0 273.68, 88.75 999.0, 999.0 in-out in 8.073 Saltbr-out 4.053 HRD-in -68.69, -51.85 75.17, -15.43 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.61, -27.95 999.0, -18.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.181 0.198 B 325 261 38 0 0 25 [[20, 290]] 1.0 6oko Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IX2A Q9QZL0 15 311 486.0 1SU:401 Type2 Inactive DFGout 13.607 10.072 None -146.73, -176.51 -148.17, 113.74 -116.86, 999.0 317.74, 115.44 999.0, 999.0 in-none in 7.899 Saltbr-none 999.0 HRD-in -70.96, -52.24 73.86, -6.08 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -168.68 APE8-rot-out 182.67 APE67-dihe-in -67.86, -14.71 -70.15, -13.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.39 0.23 0.276 A 325 259 38 0 0 24 [[20, 290]] 1.0 9ix2 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IX3A Q9QZL0 15 311 486.0 A1EAA:401 Type2 Inactive DFGout 14.462 9.352 None -150.28, 178.71 -143.53, 103.62 -60.36, 999.0 274.25, 88.39 999.0, 999.0 in-in in 8.252 Saltbr-in 2.847 HRD-in -67.38, -44.32 61.93, 0.39 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.2 APE8-rot-out 176.48 APE67-dihe-in -68.17, -19.26 -97.75, 5.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.07 0.23 0.26 A 325 260 37 0 0 24 [[20, 290]] 1.0 9ix3 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IX3B Q9QZL0 15 310 486.0 A1EAA:401 Type2 Inactive DFGout 14.445 9.086 None -149.14, -178.68 -147.64, 102.25 -63.03, 999.0 274.85, 88.05 999.0, 999.0 in-in in 8.271 Saltbr-in 3.327 HRD-in -74.32, -44.8 71.29, -11.12 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -73.16, -8.52 999.0, -9.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.07 0.23 0.26 B 325 253 43 0 0 25 [[20, 290]] 1.0 9ix3 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 4M66B Q9QZL0 14 313 486.0 No_ligand No_ligand None DFGin 6.257 13.906 BLAminus -131.04, 173.42 61.1, 97.0 -115.48, 32.44 299.35, 93.88 -64.23, -38.27 in-in in 8.429 Saltbr-in 2.396 HRD-in -76.55, -48.31 73.84, -8.87 in-in-none SNCiin in-none ActLoopNT-in 2.49 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -70.87, -4.86 999.0, -21.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C111A None None XRAY 2.401 0.217 0.258 B 325 265 35 0 0 19 [[20, 290]] 1.0 4m66 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IX2B Q9QZL0 13 313 486.0 No_ligand No_ligand None DFGin 6.33 13.859 BLAminus -148.46, -178.51 60.6, 72.26 -92.16, 23.07 300.89, 97.28 -69.06, -26.68 in-in in 8.252 Saltbr-in 2.687 HRD-in -69.09, -48.01 69.12, -1.67 in-in-none SNCiin in-none ActLoopNT-in 2.774 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -51.27 APE8-rot-in 299.69 APE67-dihe-in -70.84, -21.22 -92.23, 4.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.39 0.23 0.276 B 325 264 37 0 0 19 [[20, 290]] 1.0 9ix2 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IX0A Q9QZL0 15 312 486.0 A1D99:401 Type1 None DFGin 6.175 14.031 BLAminus -143.29, 171.72 60.25, 76.29 -91.31, 27.47 299.18, 101.06 -70.53, -25.92 in-in in 8.508 Saltbr-in 2.757 HRD-in -63.18, -53.03 70.09, 0.01 in-in-none SNCiin in-none ActLoopNT-in 2.729 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -148.23 APE8-dihe-in -50.23, 128.69 APE8-rot-in 297.82 APE67-dihe-in -60.6, -26.4 -69.61, -32.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.583 None None None XRAY 2.1 0.205 0.243 A 325 269 29 0 0 17 [[20, 290]] 1.0 9ix0 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IX0B Q9QZL0 13 311 486.0 A1D99:401 Type1 None DFGin 6.254 13.905 BLAminus -148.35, -179.19 58.25, 77.83 -96.97, 28.2 308.45, 66.53 -68.51, -30.59 in-in in 8.662 Saltbr-in 3.043 HRD-in -69.9, -51.03 76.13, -3.93 in-in-none SNCiin in-none ActLoopNT-in 2.728 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -72.8 APE8-rot-none 999.0 APE67-dihe-in -63.77, -19.86 -71.87, -10.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.205 0.243 B 325 255 44 0 0 19 [[20, 290]] 1.0 9ix0 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IX1A Q9QZL0 15 313 486.0 PP2:60401 Type1 None DFGin 5.913 14.386 BLAminus -149.4, 179.25 53.78, 84.76 -98.68, 28.86 296.35, 93.86 -68.88, -29.86 in-in in 8.49 Saltbr-in 2.82 HRD-in -73.45, -52.59 70.92, 5.37 in-in-none SNCiin in-none ActLoopNT-in 2.862 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.32, -23.19 999.0, 1.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.31 0.221 0.255 A 325 268 31 0 0 19 [[20, 290]] 1.0 9ix1 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9LVGA Q9QZL0 14 312 486.0 LKR:401 Type1 None DFGin 5.994 13.863 BLAminus -143.57, 178.7 54.72, 82.38 -98.67, 31.08 302.44, 93.08 -71.32, -23.61 in-in in 8.503 Saltbr-in 2.534 HRD-in -71.75, -46.38 68.0, 5.54 in-in-none SNCiin in-none ActLoopNT-in 2.84 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -47.4 APE8-rot-none 999.0 APE67-dihe-in -65.94, -24.52 -63.59, -34.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.03 0.218 0.236 A 325 268 31 0 0 18 [[20, 290]] 1.0 9lvg Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9LVGB Q9QZL0 14 311 486.0 LKR:401 Type1 None DFGin 6.084 13.882 BLAminus -141.96, 177.06 54.0, 89.88 -106.67, 29.11 304.14, 81.96 -69.4, -38.51 in-in in 8.544 Saltbr-in 2.772 HRD-in -66.91, -46.81 64.26, 6.52 in-in-none SNCiin in-none ActLoopNT-in 2.685 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.66, -18.61 999.0, 5.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.03 0.218 0.236 B 325 250 48 0 0 19 [[20, 290]] 1.0 9lvg Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9LVHA Q9QZL0 13 312 486.0 MYF:401 Type1 None DFGin 6.25 14.259 BLAminus -136.98, 168.96 62.75, 89.32 -105.42, 15.63 293.79, 91.31 -62.49, -27.0 in-in in 8.376 Saltbr-in 2.879 HRD-in -72.81, -50.94 74.54, 2.05 in-in-none SNCiin in-none ActLoopNT-in 2.778 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.25, -26.93 999.0, -1.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.38 0.251 0.271 A 325 263 37 0 0 19 [[20, 290]] 1.0 9lvh Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9LVHB Q9QZL0 13 312 486.0 MYF:401 Type1 None DFGin 6.144 14.058 BLAminus -139.36, 174.01 57.76, 83.37 -93.9, 23.89 297.93, 87.69 -58.87, -31.82 in-in in 8.581 Saltbr-in 2.817 HRD-in -67.48, -56.31 78.93, 2.25 in-in-none SNCiin in-none ActLoopNT-in 2.713 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.93 APE8-rot-in 302.42 APE67-dihe-in -61.51, -26.08 -64.96, -15.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.38 0.251 0.271 B 325 266 34 0 0 18 [[20, 290]] 1.0 9lvh Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IWWA Q9QZL0 13 312 486.0 A1D96:401 Type1.5_Back None DFGin 5.986 13.437 BLAminus -144.16, 173.05 63.98, 84.62 -101.11, 24.14 300.74, 93.26 -71.71, -26.9 in-in in 8.088 Saltbr-in 2.888 HRD-in -71.21, -48.68 73.29, -5.08 in-in-none SNCiin in-none ActLoopNT-in 2.715 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -153.01 APE9-dihe-na 106.36, 163.97 APE8-dihe-in -82.15, 128.32 APE8-rot-in 297.93 APE67-dihe-in -63.89, -25.3 -71.15, -26.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.411 APE9-dist-in 5.408 None None None XRAY 1.93 0.183 0.209 A 325 284 16 0 0 16 [[20, 290]] 1.0 9iww Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IWZA Q9QZL0 13 312 486.0 ZOV:401 Type1.5_Back None DFGin 6.167 13.332 BLAminus -140.79, 171.83 65.16, 90.29 -104.26, 18.26 298.04, 95.08 -65.53, -28.75 in-in in 7.87 Saltbr-in 2.858 HRD-in -70.03, -51.19 78.93, -3.69 in-in-none SNCiin in-none ActLoopNT-in 2.767 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -29.88 APE9-dihe-na 105.08, -174.88 APE8-dihe-in -93.5, 124.97 APE8-rot-in 297.04 APE67-dihe-in -65.66, -19.22 -68.64, -29.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.387 APE9-dist-in 5.623 None None None XRAY 1.82 0.178 0.211 A 325 285 15 0 0 15 [[20, 290]] 1.0 9iwz Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IWXA Q9QZL0 14 311 486.0 A1D96:401 Type1.5_Back None DFGin 6.485 13.836 BLAminus -139.34, 174.94 62.89, 84.12 -98.91, 17.96 292.01, 88.18 -69.55, -33.91 in-in in 8.085 Saltbr-in 2.79 HRD-in -70.26, -48.65 73.87, -6.66 in-in-none SNCiin in-none ActLoopNT-in 2.711 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 126.28 APE8-rot-in 301.73 APE67-dihe-in -62.28, -24.57 -68.16, -31.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R69H None None XRAY 1.99 0.189 0.236 A 325 280 18 0 0 18 [[20, 290]] 1.0 9iwx Mus musculus TKL_RIPK3_MOUSE TKL 7.7e-60 208.6 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3

TKL_RIPK3 (Receptor-interacting serine/threonine-protein kinase 3)

Total number of chains: 30
Active chains: 0
Family: TKL
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 18 60.0% 9IWZA
DFGin None 5 16.7% 9LFVA
DFGout None 5 16.7% 6OKOA
DFGin BLBplus 2 6.7% 4M69A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
RIPK3_MOUSE 4M66A Q9QZL0 15 312 486.0 No_ligand No_ligand Inactive DFGin 6.055 13.859 BLAminus -141.67, 175.97 66.14, 79.95 -103.85, 30.15 301.98, 92.84 -68.28, -27.67 in-in in 8.633 Saltbr-in 2.752 HRD-in -64.88, -51.98 74.08, -8.59 in-in-out SNCiio in-out ActLoopNT-in 2.797 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -54.85 APE8-dihe-out -46.37, -3.77 APE8-rot-out 175.43 APE67-dihe-in -70.4, -20.56 -55.19, -35.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.984 C111A None None XRAY 2.401 0.217 0.258 A 325 268 30 0 0 15 [[20, 290]] 1.0 4m66 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IWYA Q9QZL0 15 311 486.0 A1D97:60401 Type1 Inactive DFGin 7.381 13.315 BLAminus -145.3, 163.78 57.87, 69.65 -81.11, 58.68 314.75, 92.73 105.23, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.94, -45.69 67.4, -3.27 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -54.74 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.52 0.27 0.299 A 325 243 54 0 0 25 [[20, 290]] 1.0 9iwy Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IX1B Q9QZL0 15 313 486.0 PP2:60401 Type1 Inactive DFGin 6.167 14.352 BLAminus -148.46, 177.74 57.68, 87.36 -104.16, 25.73 298.93, 91.95 -67.83, -27.46 in-in in 8.157 Saltbr-in 2.678 HRD-in -72.53, -47.36 68.74, 3.0 in-in-out SNCiio in-out ActLoopNT-in 2.805 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -77.43 APE8-rot-out 57.1 APE67-dihe-in -61.06, -23.36 -77.17, -1.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.31 0.221 0.255 B 325 255 44 0 0 18 [[20, 290]] 1.0 9ix1 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IWWB Q9QZL0 13 313 486.0 A1D96:401 Type1.5_Back Inactive DFGin 5.993 13.551 BLAminus -143.56, 174.68 61.93, 81.26 -97.31, 23.35 302.29, 97.52 -69.97, -24.78 in-in in 8.395 Saltbr-in 2.894 HRD-in -65.13, -51.7 74.4, -3.35 in-in-out SNCiio in-out ActLoopNT-in 2.711 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -147.97, -2.69 APE9-dihe-na -82.83, -170.1 APE8-dihe-in -66.65, 153.26 APE8-rot-out 178.53 APE67-dihe-in -65.76, -22.0 -107.76, 6.47 APE12-dist-out 6.099 APE11-dist-out 7.592 APE10-dist-out 11.249 APE9-dist-out 9.921 None None None XRAY 1.93 0.183 0.209 B 325 274 27 0 0 14 [[20, 290]] 1.0 9iww Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IWZB Q9QZL0 14 313 486.0 ZOV:401 Type1.5_Back Inactive DFGin 5.997 13.305 BLAminus -144.47, 173.55 62.65, 86.08 -102.43, 20.57 300.27, 99.76 -65.16, -25.91 in-in in 8.213 Saltbr-in 2.684 HRD-in -67.11, -51.33 74.52, -2.58 in-in-out SNCiio in-out ActLoopNT-in 2.849 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 2.11 APE9-dihe-na -92.49, -170.4 APE8-dihe-in -66.48, 151.74 APE8-rot-out 179.71 APE67-dihe-in -61.05, -23.54 -107.82, 2.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.509 APE9-dist-out 9.92 None None None XRAY 1.82 0.178 0.211 B 325 271 29 0 0 16 [[20, 290]] 1.0 9iwz Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IWXB Q9QZL0 14 313 486.0 A1D96:401 Type1.5_Back Inactive DFGin 6.375 13.839 BLAminus -141.47, 172.49 62.47, 82.69 -97.63, 22.27 297.98, 86.87 -70.61, -24.89 in-in in 8.39 Saltbr-in 2.907 HRD-in -67.61, -51.07 72.36, -2.33 in-in-out SNCiio in-out ActLoopNT-in 2.806 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 13.18 APE9-dihe-na -80.39, -173.32 APE8-dihe-in -63.1, 154.41 APE8-rot-out 170.77 APE67-dihe-in -64.75, -25.15 -109.43, 9.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.098 APE9-dist-out 9.836 R69H None None XRAY 1.99 0.189 0.236 B 325 270 30 0 0 16 [[20, 290]] 1.0 9iwx Mus musculus TKL_RIPK3_MOUSE TKL 7.7e-60 208.6 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 4M69A Q9QZL0 12 312 486.0 ANP:60401 ATPlike Inactive DFGin 6.32 13.402 BLBplus -137.99, 167.73 62.19, 26.69 -80.85, 141.15 41.42, 94.11 79.17, -4.63 out-out out 16.188 Saltbr-out 16.694 HRD-in -64.86, -72.1 85.35, 0.02 out-out-out SNCooo out-out ActLoopNT-out 6.434 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -38.44, -35.37 APE9-dihe-na -67.82, -39.64 APE8-dihe-out -81.63, -25.9 APE8-rot-out 193.07 APE67-dihe-in -56.22, -29.66 -74.57, -26.5 APE12-dist-out 15.23 APE11-dist-out 16.641 APE10-dist-out 19.236 APE9-dist-out 12.364 None SEP184,TPO231,SEP232 SEP184,TPO231,SEP232 XRAY 2.497 0.222 0.246 A 313 287 14 0 0 14 [[20, 290]] 1.0 4m69 Mus musculus TKL_RIPK3_MOUSE TKL 7.1e-60 208.7 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9LFWA Q9QZL0 5 312 486.0 A1D97:60401 Type1.5_Back Inactive DFGin 6.585 13.126 BLBplus -131.15, 162.08 64.23, 14.69 -67.09, 146.1 51.36, 90.93 77.16, -15.72 out-out out 15.978 Saltbr-out 17.155 HRD-in -70.85, -60.94 79.59, -9.5 out-out-out SNCooo out-out ActLoopNT-out 6.34 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 156.06 APE8-rot-out 186.0 APE67-dihe-in -61.62, -27.57 -97.1, 3.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R69H None None XRAY 1.59 0.204 0.238 A 325 290 18 0 0 18 [[20, 290]] 1.0 9lfw Mus musculus TKL_RIPK3_MOUSE TKL 7.7e-60 208.6 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IWYB Q9QZL0 15 311 486.0 A1D97:60401 Type1 Inactive DFGin 6.968 14.062 None -141.15, 157.34 72.96, -21.93 37.23, 42.97 300.12, 81.7 83.46, 13.22 in-none in 9.108 Saltbr-none 999.0 HRD-in -65.47, -42.38 68.5, -9.87 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -44.45 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.52 0.27 0.299 B 325 249 48 0 0 23 [[20, 290]] 1.0 9iwy Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9LFVB Q9QZL0 14 311 486.0 A1EJP:60401 Type1 Inactive DFGin 7.019 14.076 None -145.36, 167.9 72.34, -50.6 63.07, 38.87 298.34, 85.19 73.03, 11.82 out-out out 13.229 Saltbr-out 11.321 HRD-in -75.72, -32.7 64.15, -13.21 out-out-none SNCoon out-none ActLoopNT-out 11.183 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -75.83, -8.32 999.0, 22.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.78 0.249 0.28 B 325 256 42 0 0 20 [[20, 290]] 1.0 9lfv Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9LFVC Q9QZL0 14 311 486.0 A1EJP:60401 Type1 Inactive DFGin 7.013 13.871 None -142.11, 177.11 62.46, -56.12 66.46, 24.11 299.69, 104.14 92.05, 19.19 out-none out 13.512 Saltbr-none 999.0 HRD-in -83.63, -35.26 71.15, -28.83 none-out-none SNCnon out-none ActLoopNT-out 11.309 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -81.07, -0.33 999.0, 20.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.78 0.249 0.28 C 325 250 48 0 0 21 [[20, 290]] 1.0 9lfv Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9LFVD Q9QZL0 13 311 486.0 A1EJP:60401 Type1 Inactive DFGin 7.065 13.893 None -144.3, 176.32 70.73, -56.46 59.33, 41.69 299.17, 86.38 64.18, 23.93 out-none out 14.401 Saltbr-none 999.0 HRD-in -78.46, -41.38 66.14, 7.65 none-out-none SNCnon out-none ActLoopNT-out 11.261 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.45 APE8-rot-none 999.0 APE67-dihe-in -71.04, -19.34 -115.22, 23.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.78 0.249 0.28 D 325 255 44 0 0 20 [[20, 290]] 1.0 9lfv Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9LFVA Q9QZL0 13 311 486.0 A1EJO:60401,A1EJP:60402 Type1,Type1 Inactive DFGin 7.33 14.14 None -146.0, 165.54 71.61, -51.04 65.28, 34.98 298.07, 86.12 73.14, 14.66 out-none out 13.261 Saltbr-none 999.0 HRD-in -73.78, -36.28 68.29, -16.9 none-out-out SNCnoo out-out ActLoopNT-out 11.387 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 42.16 APE8-dihe-in -76.77, 175.03 APE8-rot-none 999.0 APE67-dihe-in -74.57, -14.2 -136.84, 23.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.066 None None None XRAY 2.78 0.249 0.28 A 325 259 40 0 0 18 [[20, 290]] 1.0 9lfv Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 6OKOA Q9QZL0 14 311 486.0 1FN:4000 Type2 Inactive DFGout 14.657 9.479 None -150.96, 174.92 -144.36, 105.73 -56.39, 999.0 272.32, 88.92 999.0, 999.0 in-in in 8.288 Saltbr-in 2.699 HRD-in -68.52, -53.05 75.17, -14.49 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -55.0 APE8-dihe-out -66.23, -6.09 APE8-rot-out 181.11 APE67-dihe-in -65.76, -28.77 -67.24, -21.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.291 None None None XRAY 2.1 0.181 0.198 A 325 263 35 0 0 23 [[20, 290]] 1.0 6oko Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 6OKOB Q9QZL0 13 311 486.0 1FN:4000 Type2 Inactive DFGout 14.797 9.688 None -145.94, 173.66 -143.61, 99.01 -60.19, 999.0 273.68, 88.75 999.0, 999.0 in-out in 8.073 Saltbr-out 4.053 HRD-in -68.69, -51.85 75.17, -15.43 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.61, -27.95 999.0, -18.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.181 0.198 B 325 261 38 0 0 25 [[20, 290]] 1.0 6oko Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IX2A Q9QZL0 15 311 486.0 1SU:401 Type2 Inactive DFGout 13.607 10.072 None -146.73, -176.51 -148.17, 113.74 -116.86, 999.0 317.74, 115.44 999.0, 999.0 in-none in 7.899 Saltbr-none 999.0 HRD-in -70.96, -52.24 73.86, -6.08 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -168.68 APE8-rot-out 182.67 APE67-dihe-in -67.86, -14.71 -70.15, -13.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.39 0.23 0.276 A 325 259 38 0 0 24 [[20, 290]] 1.0 9ix2 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IX3A Q9QZL0 15 311 486.0 A1EAA:401 Type2 Inactive DFGout 14.462 9.352 None -150.28, 178.71 -143.53, 103.62 -60.36, 999.0 274.25, 88.39 999.0, 999.0 in-in in 8.252 Saltbr-in 2.847 HRD-in -67.38, -44.32 61.93, 0.39 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.2 APE8-rot-out 176.48 APE67-dihe-in -68.17, -19.26 -97.75, 5.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.07 0.23 0.26 A 325 260 37 0 0 24 [[20, 290]] 1.0 9ix3 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IX3B Q9QZL0 15 310 486.0 A1EAA:401 Type2 Inactive DFGout 14.445 9.086 None -149.14, -178.68 -147.64, 102.25 -63.03, 999.0 274.85, 88.05 999.0, 999.0 in-in in 8.271 Saltbr-in 3.327 HRD-in -74.32, -44.8 71.29, -11.12 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -73.16, -8.52 999.0, -9.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.07 0.23 0.26 B 325 253 43 0 0 25 [[20, 290]] 1.0 9ix3 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 4M66B Q9QZL0 14 313 486.0 No_ligand No_ligand None DFGin 6.257 13.906 BLAminus -131.04, 173.42 61.1, 97.0 -115.48, 32.44 299.35, 93.88 -64.23, -38.27 in-in in 8.429 Saltbr-in 2.396 HRD-in -76.55, -48.31 73.84, -8.87 in-in-none SNCiin in-none ActLoopNT-in 2.49 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -70.87, -4.86 999.0, -21.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C111A None None XRAY 2.401 0.217 0.258 B 325 265 35 0 0 19 [[20, 290]] 1.0 4m66 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IX2B Q9QZL0 13 313 486.0 No_ligand No_ligand None DFGin 6.33 13.859 BLAminus -148.46, -178.51 60.6, 72.26 -92.16, 23.07 300.89, 97.28 -69.06, -26.68 in-in in 8.252 Saltbr-in 2.687 HRD-in -69.09, -48.01 69.12, -1.67 in-in-none SNCiin in-none ActLoopNT-in 2.774 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -51.27 APE8-rot-in 299.69 APE67-dihe-in -70.84, -21.22 -92.23, 4.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.39 0.23 0.276 B 325 264 37 0 0 19 [[20, 290]] 1.0 9ix2 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IX0A Q9QZL0 15 312 486.0 A1D99:401 Type1 None DFGin 6.175 14.031 BLAminus -143.29, 171.72 60.25, 76.29 -91.31, 27.47 299.18, 101.06 -70.53, -25.92 in-in in 8.508 Saltbr-in 2.757 HRD-in -63.18, -53.03 70.09, 0.01 in-in-none SNCiin in-none ActLoopNT-in 2.729 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -148.23 APE8-dihe-in -50.23, 128.69 APE8-rot-in 297.82 APE67-dihe-in -60.6, -26.4 -69.61, -32.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.583 None None None XRAY 2.1 0.205 0.243 A 325 269 29 0 0 17 [[20, 290]] 1.0 9ix0 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IX0B Q9QZL0 13 311 486.0 A1D99:401 Type1 None DFGin 6.254 13.905 BLAminus -148.35, -179.19 58.25, 77.83 -96.97, 28.2 308.45, 66.53 -68.51, -30.59 in-in in 8.662 Saltbr-in 3.043 HRD-in -69.9, -51.03 76.13, -3.93 in-in-none SNCiin in-none ActLoopNT-in 2.728 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -72.8 APE8-rot-none 999.0 APE67-dihe-in -63.77, -19.86 -71.87, -10.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.205 0.243 B 325 255 44 0 0 19 [[20, 290]] 1.0 9ix0 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IX1A Q9QZL0 15 313 486.0 PP2:60401 Type1 None DFGin 5.913 14.386 BLAminus -149.4, 179.25 53.78, 84.76 -98.68, 28.86 296.35, 93.86 -68.88, -29.86 in-in in 8.49 Saltbr-in 2.82 HRD-in -73.45, -52.59 70.92, 5.37 in-in-none SNCiin in-none ActLoopNT-in 2.862 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.32, -23.19 999.0, 1.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.31 0.221 0.255 A 325 268 31 0 0 19 [[20, 290]] 1.0 9ix1 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9LVGA Q9QZL0 14 312 486.0 LKR:401 Type1 None DFGin 5.994 13.863 BLAminus -143.57, 178.7 54.72, 82.38 -98.67, 31.08 302.44, 93.08 -71.32, -23.61 in-in in 8.503 Saltbr-in 2.534 HRD-in -71.75, -46.38 68.0, 5.54 in-in-none SNCiin in-none ActLoopNT-in 2.84 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -47.4 APE8-rot-none 999.0 APE67-dihe-in -65.94, -24.52 -63.59, -34.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.03 0.218 0.236 A 325 268 31 0 0 18 [[20, 290]] 1.0 9lvg Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9LVGB Q9QZL0 14 311 486.0 LKR:401 Type1 None DFGin 6.084 13.882 BLAminus -141.96, 177.06 54.0, 89.88 -106.67, 29.11 304.14, 81.96 -69.4, -38.51 in-in in 8.544 Saltbr-in 2.772 HRD-in -66.91, -46.81 64.26, 6.52 in-in-none SNCiin in-none ActLoopNT-in 2.685 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.66, -18.61 999.0, 5.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.03 0.218 0.236 B 325 250 48 0 0 19 [[20, 290]] 1.0 9lvg Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9LVHA Q9QZL0 13 312 486.0 MYF:401 Type1 None DFGin 6.25 14.259 BLAminus -136.98, 168.96 62.75, 89.32 -105.42, 15.63 293.79, 91.31 -62.49, -27.0 in-in in 8.376 Saltbr-in 2.879 HRD-in -72.81, -50.94 74.54, 2.05 in-in-none SNCiin in-none ActLoopNT-in 2.778 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.25, -26.93 999.0, -1.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.38 0.251 0.271 A 325 263 37 0 0 19 [[20, 290]] 1.0 9lvh Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9LVHB Q9QZL0 13 312 486.0 MYF:401 Type1 None DFGin 6.144 14.058 BLAminus -139.36, 174.01 57.76, 83.37 -93.9, 23.89 297.93, 87.69 -58.87, -31.82 in-in in 8.581 Saltbr-in 2.817 HRD-in -67.48, -56.31 78.93, 2.25 in-in-none SNCiin in-none ActLoopNT-in 2.713 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.93 APE8-rot-in 302.42 APE67-dihe-in -61.51, -26.08 -64.96, -15.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.38 0.251 0.271 B 325 266 34 0 0 18 [[20, 290]] 1.0 9lvh Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IWWA Q9QZL0 13 312 486.0 A1D96:401 Type1.5_Back None DFGin 5.986 13.437 BLAminus -144.16, 173.05 63.98, 84.62 -101.11, 24.14 300.74, 93.26 -71.71, -26.9 in-in in 8.088 Saltbr-in 2.888 HRD-in -71.21, -48.68 73.29, -5.08 in-in-none SNCiin in-none ActLoopNT-in 2.715 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -153.01 APE9-dihe-na 106.36, 163.97 APE8-dihe-in -82.15, 128.32 APE8-rot-in 297.93 APE67-dihe-in -63.89, -25.3 -71.15, -26.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.411 APE9-dist-in 5.408 None None None XRAY 1.93 0.183 0.209 A 325 284 16 0 0 16 [[20, 290]] 1.0 9iww Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IWZA Q9QZL0 13 312 486.0 ZOV:401 Type1.5_Back None DFGin 6.167 13.332 BLAminus -140.79, 171.83 65.16, 90.29 -104.26, 18.26 298.04, 95.08 -65.53, -28.75 in-in in 7.87 Saltbr-in 2.858 HRD-in -70.03, -51.19 78.93, -3.69 in-in-none SNCiin in-none ActLoopNT-in 2.767 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -29.88 APE9-dihe-na 105.08, -174.88 APE8-dihe-in -93.5, 124.97 APE8-rot-in 297.04 APE67-dihe-in -65.66, -19.22 -68.64, -29.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.387 APE9-dist-in 5.623 None None None XRAY 1.82 0.178 0.211 A 325 285 15 0 0 15 [[20, 290]] 1.0 9iwz Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
RIPK3_MOUSE 9IWXA Q9QZL0 14 311 486.0 A1D96:401 Type1.5_Back None DFGin 6.485 13.836 BLAminus -139.34, 174.94 62.89, 84.12 -98.91, 17.96 292.01, 88.18 -69.55, -33.91 in-in in 8.085 Saltbr-in 2.79 HRD-in -70.26, -48.65 73.87, -6.66 in-in-none SNCiin in-none ActLoopNT-in 2.711 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 126.28 APE8-rot-in 301.73 APE67-dihe-in -62.28, -24.57 -68.16, -31.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R69H None None XRAY 1.99 0.189 0.236 A 325 280 18 0 0 18 [[20, 290]] 1.0 9iwx Mus musculus TKL_RIPK3_MOUSE TKL 7.7e-60 208.6 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3