CMGC_CDK12 (Cyclin-dependent kinase 12)

Total number of chains: 109
Active chains: 10
Uniprot: CDK12_HUMAN
Kinase Domain Residues: 727 - 1020
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 53 48.6% AF-Q9NYV4-K1A
DFGin None 30 27.5% 8BU1B
DFGin ABAminus 26 23.9% 8BUNB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q9NYV4-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 719 - 1028 0 None None Cyclin-dependent kinase 12
AF-Q9NYV4-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 719 - 1028 0 None None Cyclin-dependent kinase 12
8BU7B 3.245 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
8BU7H 3.245 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
6TD3E 3.46 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RC8 Type1 715 - 1047 0 TPO893 K965R Cyclin-dependent kinase 12
8BU3E 3.42 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RSI Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BULE 3.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RSU Type1 715 - 1038 0 TPO893 None Cyclin-dependent kinase 12
8BUME 3.36 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii T6X Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BUPH 3.41 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RWN Type1 715 - 1028 0 TPO893 K965R Cyclin-dependent kinase 12
8P81A 2.68 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 716 - 1035 0 TPO893 None Cyclin-dependent kinase 12
8BU2H 3.13 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RVQ Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
8BU4B 3.09 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQL Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
8BU4H 3.09 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii RQL Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
8BU5B 3.134 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 713 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
8BU5H 3.134 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 713 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
8BU9H 3.51 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RRC Type1 715 - 1038 0 TPO893 K965R Cyclin-dependent kinase 12
8BUAB 3.193 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RVH Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BUAE 3.193 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii RVH Type1 715 - 1033 0 TPO893 K965R Cyclin-dependent kinase 12
8BUAH 3.193 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii RVH Type1 715 - 1034 0 TPO893 K965R Cyclin-dependent kinase 12
8BUCB 3.85 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RKO Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12
8BUDB 3.2 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RP9 Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
8BUDH 3.2 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RP9 Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
8BUEH 3.25 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RVU Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
8BUIB 3.5 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RV6 Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12
8BUIH 3.5 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RV6 Type1 715 - 1038 0 TPO893 K965R Cyclin-dependent kinase 12
8BULH 3.4 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RSU Type1 715 - 1034 0 TPO893 None Cyclin-dependent kinase 12
8BUNB 3.08 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RNF Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12
8BUNH 3.08 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RNF Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
8BUOB 3.58 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RLC Type1 715 - 1040 0 TPO893 K965R Cyclin-dependent kinase 12
8BURE 3.64 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQU Type1 715 - 1040 0 TPO893 K965R Cyclin-dependent kinase 12
8BUSH 3.26 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMX Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
8BUTB 3.25 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQ5 Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BUTH 3.25 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RQ5 Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
7NXKA 3.0 Inactive DFGin‑ABAminus in-none in-out nonTYR APEdihe_aaioi APEdist_iiii UUB Type1 715 - 1040 0 TPO893 None Cyclin-dependent kinase 12
9FMRE 3.9 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 714 - 1042 0 TPO893 None Cyclin-dependent kinase 12
9FMRH 3.9 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 714 - 1044 0 TPO893 None Cyclin-dependent kinase 12
4CXAA 3.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 718 - 1050 0 TPO893 None Cyclin-dependent kinase 12
4NSTA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 716 - 1046 0 TPO893 None Cyclin-dependent kinase 12
4NSTC 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 717 - 1045 0 TPO893 None Cyclin-dependent kinase 12
4UN0C 3.15 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaooi APEdist_iiii No_ligand No_ligand 719 - 1036 0 TPO893 None Cyclin-dependent kinase 12
4UN0D 3.15 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaooi APEdist_iiii No_ligand No_ligand 723 - 1024 0 TPO893 None Cyclin-dependent kinase 12
4CXAC 3.15 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 718 - 1048 0 TPO893 None Cyclin-dependent kinase 12
8BU2E 3.13 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BUDE 3.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
8BUGE 3.53 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
6B3EA 3.06 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii CJM Type1 717 - 1036 0 TPO893 None Cyclin-dependent kinase 12
6B3EC 3.06 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii CJM Type1 719 - 1036 0 TPO893 None Cyclin-dependent kinase 12
5ACBC 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5I1 Type1 716 - 1040 0 TPO893 None Cyclin-dependent kinase 12
5ACBD 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5I1 Type1 718 - 1044 0 TPO893 None Cyclin-dependent kinase 12
9JK1A 2.72 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii A1EB3 Type1 717 - 1039 0 TPO893 None Cyclin-dependent kinase 12
9JK1B 2.72 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii A1EB3 Type1 715 - 1039 0 TPO893 None Cyclin-dependent kinase 12
6TD3B 3.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RC8 Type1 715 - 1047 0 TPO893 K965R Cyclin-dependent kinase 12
6TD3H 3.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_iiii RC8 Type1 715 - 1047 0 TPO893 K965R Cyclin-dependent kinase 12
8BU1E 2.98 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQL Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
8BU4E 3.09 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii RQL Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BU6E 3.45 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii RQE Type1 715 - 1038 0 TPO893 K965R Cyclin-dependent kinase 12
8BU7E 3.245 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RS5 Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
8BU9E 3.51 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RRC Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BUBB 3.42 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo RNU Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12
8BUBE 3.42 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iooo RNU Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
8BUCE 3.85 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RKO Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BUEE 3.25 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RVU Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BUFE 3.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RW6 Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
8BUHE 3.79 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RR9 Type1 715 - 1034 0 TPO893 K965R Cyclin-dependent kinase 12
8BUIE 3.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiio RV6 Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BUJE 3.62 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii RUW Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
8BUKE 3.41 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RWE Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BUNE 3.08 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RNF Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BUOE 3.58 Inactive DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RLC Type1 715 - 1040 0 TPO893 K965R Cyclin-dependent kinase 12
8BUPB 3.41 Inactive DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RWN Type1 715 - 1027 0 TPO893 K965R Cyclin-dependent kinase 12
8BUPE 3.41 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio RWN Type1 715 - 1027 0 TPO893 K965R Cyclin-dependent kinase 12
8BUQB 3.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQ9 Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BUQE 3.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQ9 Type1 715 - 1027 0 TPO893 K965R Cyclin-dependent kinase 12
8BURB 3.64 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQU Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
8BUSB 3.26 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RMX Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BUTE 3.25 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQ5 Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
6CKXA 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 8M1 Type1 722 - 1024 0 TPO893 None Cyclin-dependent kinase 12
6CKXC 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 8M1 Type1 722 - 1024 0 TPO893 None Cyclin-dependent kinase 12
7NXKC 3.0 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaioi APEdist_iiii UUB Type1 717 - 1040 0 TPO893 None Cyclin-dependent kinase 12
8BUGH 3.53 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BU1B 2.98 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQL Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
8BU1H 2.98 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQL Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
8BU2B 3.13 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RVQ Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12
8BU3B 3.42 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RSI Type1 715 - 1040 0 TPO893 K965R Cyclin-dependent kinase 12
8BU3H 3.42 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RSI Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
8BU5E 3.134 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 713 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
8BU6B 3.45 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQE Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BU6H 3.45 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiii RQE Type1 715 - 1038 0 TPO893 K965R Cyclin-dependent kinase 12
8BU9B 3.51 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RRC Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BUBH 3.42 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooo APEdist_iiii RNU Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
8BUCH 3.85 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RKO Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
8BUEB 3.25 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RVU Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
8BUFB 3.3 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RW6 Type1 715 - 1033 0 TPO893 K965R Cyclin-dependent kinase 12
8BUFH 3.3 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii RW6 Type1 715 - 1032 0 TPO893 K965R Cyclin-dependent kinase 12
8BUGB 3.53 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RPW Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12
8BUHB 3.79 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RR9 Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BUHH 3.79 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RR9 Type1 715 - 1033 0 TPO893 K965R Cyclin-dependent kinase 12
8BUJB 3.62 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RUW Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12
8BUJH 3.62 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RUW Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
8BUKB 3.41 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RWE Type1 715 - 1040 0 TPO893 K965R Cyclin-dependent kinase 12
8BUKH 3.41 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RWE Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
8BULB 3.4 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RSU Type1 715 - 1039 0 TPO893 None Cyclin-dependent kinase 12
8BUMB 3.36 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii T6X Type1 715 - 1040 0 TPO893 K965R Cyclin-dependent kinase 12
8BUMH 3.36 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii T6X Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BUOH 3.58 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RLC Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
8BUQH 3.2 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQ9 Type1 715 - 1035 0 TPO893 K965R Cyclin-dependent kinase 12
8BURH 3.64 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQU Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
8BUSE 3.26 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RMX Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
9FMRB 3.9 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 714 - 1047 0 TPO893 None Cyclin-dependent kinase 12

CMGC_CDK12 (Cyclin-dependent kinase 12)

Total number of chains: 109
Active chains: 10
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 53 48.6% AF-Q9NYV4-K1A
DFGin None 30 27.5% 8BU1B
DFGin ABAminus 26 23.9% 8BUNB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CDK12_HUMAN AF-Q9NYV4-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 719 - 1028 0 None None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN AF-Q9NYV4-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 719 - 1028 0 None None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU7B 3.245 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU7H 3.245 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 6TD3E 3.46 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RC8 Type1 715 - 1047 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU3E 3.42 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RSI Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BULE 3.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RSU Type1 715 - 1038 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUME 3.36 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii T6X Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUPH 3.41 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RWN Type1 715 - 1028 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8P81A 2.68 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 716 - 1035 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU2H 3.13 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RVQ Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU4B 3.09 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQL Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU4H 3.09 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii RQL Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU5B 3.134 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 713 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU5H 3.134 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 713 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU9H 3.51 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RRC Type1 715 - 1038 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUAB 3.193 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RVH Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUAE 3.193 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii RVH Type1 715 - 1033 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUAH 3.193 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii RVH Type1 715 - 1034 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUCB 3.85 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RKO Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUDB 3.2 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RP9 Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUDH 3.2 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RP9 Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUEH 3.25 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RVU Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUIB 3.5 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RV6 Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUIH 3.5 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RV6 Type1 715 - 1038 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BULH 3.4 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RSU Type1 715 - 1034 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUNB 3.08 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RNF Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUNH 3.08 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RNF Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUOB 3.58 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RLC Type1 715 - 1040 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BURE 3.64 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQU Type1 715 - 1040 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUSH 3.26 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMX Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUTB 3.25 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQ5 Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUTH 3.25 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RQ5 Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 7NXKA 3.0 Inactive DFGin‑ABAminus in-none in-out nonTYR APEdihe_aaioi APEdist_iiii UUB Type1 715 - 1040 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 9FMRE 3.9 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 714 - 1042 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 9FMRH 3.9 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 714 - 1044 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 4CXAA 3.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 718 - 1050 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 4NSTA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 716 - 1046 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 4NSTC 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 717 - 1045 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 4UN0C 3.15 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaooi APEdist_iiii No_ligand No_ligand 719 - 1036 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 4UN0D 3.15 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaooi APEdist_iiii No_ligand No_ligand 723 - 1024 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 4CXAC 3.15 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 718 - 1048 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU2E 3.13 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUDE 3.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUGE 3.53 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 6B3EA 3.06 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii CJM Type1 717 - 1036 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 6B3EC 3.06 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii CJM Type1 719 - 1036 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 5ACBC 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5I1 Type1 716 - 1040 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 5ACBD 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 5I1 Type1 718 - 1044 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 9JK1A 2.72 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii A1EB3 Type1 717 - 1039 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 9JK1B 2.72 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii A1EB3 Type1 715 - 1039 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 6TD3B 3.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RC8 Type1 715 - 1047 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 6TD3H 3.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_iiii RC8 Type1 715 - 1047 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU1E 2.98 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQL Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU4E 3.09 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii RQL Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU6E 3.45 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii RQE Type1 715 - 1038 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU7E 3.245 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RS5 Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU9E 3.51 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RRC Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUBB 3.42 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo RNU Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUBE 3.42 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iooo RNU Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUCE 3.85 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RKO Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUEE 3.25 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RVU Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUFE 3.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RW6 Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUHE 3.79 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RR9 Type1 715 - 1034 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUIE 3.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiio RV6 Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUJE 3.62 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii RUW Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUKE 3.41 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RWE Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUNE 3.08 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RNF Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUOE 3.58 Inactive DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RLC Type1 715 - 1040 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUPB 3.41 Inactive DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RWN Type1 715 - 1027 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUPE 3.41 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio RWN Type1 715 - 1027 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUQB 3.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQ9 Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUQE 3.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQ9 Type1 715 - 1027 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BURB 3.64 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQU Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUSB 3.26 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RMX Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUTE 3.25 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQ5 Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 6CKXA 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 8M1 Type1 722 - 1024 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 6CKXC 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 8M1 Type1 722 - 1024 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 7NXKC 3.0 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaioi APEdist_iiii UUB Type1 717 - 1040 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUGH 3.53 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU1B 2.98 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQL Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU1H 2.98 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQL Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU2B 3.13 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RVQ Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU3B 3.42 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RSI Type1 715 - 1040 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU3H 3.42 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RSI Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU5E 3.134 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 713 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU6B 3.45 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQE Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU6H 3.45 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiii RQE Type1 715 - 1038 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BU9B 3.51 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RRC Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUBH 3.42 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaooo APEdist_iiii RNU Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUCH 3.85 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RKO Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUEB 3.25 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RVU Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUFB 3.3 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RW6 Type1 715 - 1033 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUFH 3.3 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii RW6 Type1 715 - 1032 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUGB 3.53 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RPW Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUHB 3.79 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RR9 Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUHH 3.79 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RR9 Type1 715 - 1033 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUJB 3.62 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RUW Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUJH 3.62 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RUW Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUKB 3.41 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RWE Type1 715 - 1040 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUKH 3.41 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RWE Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BULB 3.4 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RSU Type1 715 - 1039 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUMB 3.36 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii T6X Type1 715 - 1040 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUMH 3.36 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii T6X Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUOH 3.58 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RLC Type1 715 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUQH 3.2 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQ9 Type1 715 - 1035 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BURH 3.64 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RQU Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 8BUSE 3.26 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RMX Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CDK12_HUMAN 9FMRB 3.9 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 714 - 1047 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens

CMGC_CDK12 (Cyclin-dependent kinase 12)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism