CMGC_CDK12 (Cyclin-dependent kinase 12)

Total number of chains: 109
Active chains: 10
Uniprot: CDK12_HUMAN
Kinase Domain Residues: 727 - 1020
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 53 48.6% AF-Q9NYV4-K1A
DFGin None 30 27.5% 8BU1B
DFGin ABAminus 26 23.9% 8BUNB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK12 AF-Q9NYV4-K1A Q9NYV4 719 1028 1490.0 No_ligand No_ligand Active DFGin 6.7425 15.0213 BLAminus -135.31, 176.11 57.83, 65.7 -78.9, 19.02 283.91, 75.49 -59.53, -34.42 in-in in 8.8479 Saltbr-in 2.8717 HRD-in -74.38, -50.97 65.06, 11.96 in-in-in SNCiii in-in ActLoopNT-in 2.9537 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.35, 171.85 APE9-dihe-na 62.69, 132.06 APE8-dihe-in -56.47, 137.03 APE8-rot-in 300.21 APE67-dihe-in -68.24, -22.81 -49.07, -40.83 APE12-dist-in 13.0672 APE11-dist-in 11.1954 APE10-dist-in 6.6339 APE9-dist-in 3.3445 None None None AF2 -1.0 1.0 1.0 A 310.0 310.0 0 29 29 0 [[727, 1020]] 1.0 AF-Q9NYV4-K1 CMGC_CDK12_HUMAN CMGC 1.8e-84 289.4 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 AF-Q9NYV4-K3A Q9NYV4 719 1028 1490.0 No_ligand No_ligand Active DFGin 6.9432 15.648 BLAminus -131.2, -179.25 62.41, 52.03 -71.34, 9.91 284.98, 77.79 -61.92, -24.64 in-in in 8.4488 Saltbr-in 3.0263 HRD-in -78.33, -50.25 65.94, 8.6 in-in-in SNCiii in-in ActLoopNT-in 2.9006 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.81, 169.8 APE9-dihe-na 61.73, 134.8 APE8-dihe-in -58.63, 136.64 APE8-rot-in 295.26 APE67-dihe-in -64.98, -27.17 -49.82, -42.02 APE12-dist-in 13.4806 APE11-dist-in 11.6092 APE10-dist-in 7.1738 APE9-dist-in 3.2099 None None None AF2 -1.0 1.0 1.0 A 310.0 310.0 0 29 29 0 [[727, 1020]] 1.0 AF-Q9NYV4-K3 CMGC_CDK12_HUMAN CMGC 1.8e-84 289.4 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU7B Q9NYV4 715 1043 1490.0 No_ligand No_ligand Active DFGin 7.0774 15.5436 BLAminus -153.2, -179.33 57.0, 56.86 -76.66, 35.76 288.9, 72.8 -62.53, -36.58 in-in in 7.9444 Saltbr-in 2.9696 HRD-in -65.11, -49.8 70.58, 2.94 in-in-in SNCiii in-in ActLoopNT-in 2.9018 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.3, -42.09 APE9-dihe-na -92.76, 146.08 APE8-dihe-in -61.7, 141.25 APE8-rot-in 286.85 APE67-dihe-in -64.16, -31.94 -48.15, -39.73 APE12-dist-in 12.7959 APE11-dist-in 11.3036 APE10-dist-in 6.4396 APE9-dist-in 3.7225 K965R TPO893 TPO893 XRAY 3.245 0.193 0.219 B 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bu7 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU7H Q9NYV4 715 1043 1490.0 No_ligand No_ligand Active DFGin 6.9253 15.2163 BLAminus -150.49, -178.12 60.69, 55.85 -80.72, 28.91 286.49, 71.19 -68.37, -37.18 in-in in 7.9973 Saltbr-in 3.1269 HRD-in -67.99, -49.39 67.61, 1.86 in-in-in SNCiii in-in ActLoopNT-in 2.9304 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.1, -50.99 APE9-dihe-na -89.61, 147.06 APE8-dihe-in -59.45, 144.95 APE8-rot-in 311.35 APE67-dihe-in -64.87, -31.1 -48.4, -40.63 APE12-dist-in 13.8207 APE11-dist-in 11.6376 APE10-dist-in 7.151 APE9-dist-in 3.5678 K965R TPO893 TPO893 XRAY 3.245 0.193 0.219 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bu7 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 6TD3E Q9NYV4 715 1047 1490.0 RC8:1101 Type1 Active DFGin 7.044 15.1934 BLAminus -147.32, 173.39 63.76, 65.42 -84.24, 25.56 288.49, 76.82 -64.44, -36.48 in-in in 7.9743 Saltbr-in 3.1673 HRD-in -75.19, -47.55 67.28, 2.07 in-in-in SNCiii in-in ActLoopNT-in 2.9532 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -75.91, -39.12 APE9-dihe-na -86.17, 150.74 APE8-dihe-in -63.73, 141.42 APE8-rot-in 305.37 APE67-dihe-in -59.47, -32.88 -40.08, -54.92 APE12-dist-in 13.1756 APE11-dist-in 11.9025 APE10-dist-in 6.8549 APE9-dist-in 3.4348 K965R TPO893 TPO893 XRAY 3.46 0.195 0.22 E 344.0 333.0 0 29 29 0 [[727, 1020]] 1.0 6td3 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU3E Q9NYV4 715 1039 1490.0 RSI:1101 Type1 Active DFGin 7.1413 15.5345 BLAminus -142.27, 178.66 43.04, 82.11 -92.94, 21.36 280.44, 78.98 -62.21, -28.8 in-in in 8.1181 Saltbr-in 3.0489 HRD-in -67.4, -56.47 76.99, -0.73 in-in-in SNCiii in-in ActLoopNT-in 2.9745 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.29, 7.21 APE9-dihe-na -139.88, 150.07 APE8-dihe-in -59.05, 143.88 APE8-rot-in 303.03 APE67-dihe-in -61.38, -34.53 -56.72, -42.72 APE12-dist-in 13.1066 APE11-dist-in 12.7602 APE10-dist-in 7.1748 APE9-dist-in 3.4462 K965R TPO893 TPO893 XRAY 3.42 0.187 0.213 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu3 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BULE Q9NYV4 715 1038 1490.0 RSU:1101 Type1 Active DFGin 7.2685 15.5744 BLAminus -142.23, 173.11 51.26, 74.93 -90.42, 13.84 281.63, 81.18 -57.04, -28.57 in-in in 8.0731 Saltbr-in 3.0676 HRD-in -70.66, -53.79 75.17, 4.92 in-in-in SNCiii in-in ActLoopNT-in 2.9194 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.18, -18.48 APE9-dihe-na -95.24, 149.84 APE8-dihe-in -59.92, 143.14 APE8-rot-in 301.12 APE67-dihe-in -61.61, -35.96 -53.3, -43.95 APE12-dist-in 12.7273 APE11-dist-in 12.5302 APE10-dist-in 6.6866 APE9-dist-in 3.3853 None TPO893 TPO893 XRAY 3.4 0.179 0.215 E 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bul CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUME Q9NYV4 715 1039 1490.0 T6X:1101 Type1 Active DFGin 7.1739 15.4836 BLAminus -146.26, -169.41 35.67, 76.14 -91.08, 23.16 287.18, 101.24 -64.43, -27.28 in-in in 8.3789 Saltbr-in 3.3933 HRD-in -65.58, -57.98 78.09, 6.9 in-in-in SNCiii in-in ActLoopNT-in 3.007 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.86, -32.86 APE9-dihe-na -90.18, 155.36 APE8-dihe-in -60.4, 149.13 APE8-rot-in 310.02 APE67-dihe-in -62.09, -34.98 -57.41, -41.5 APE12-dist-in 12.684 APE11-dist-in 12.1018 APE10-dist-in 6.7473 APE9-dist-in 3.3803 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bum CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUPH Q9NYV4 715 1028 1490.0 RWN:61101 Type1 Active DFGin 7.1094 15.4064 BLAminus -147.42, -178.11 55.21, 58.82 -78.24, 30.65 278.56, 80.87 -74.41, -18.78 in-in in 8.0924 Saltbr-in 3.3148 HRD-in -72.38, -49.1 69.31, -11.39 in-in-in SNCiii in-in ActLoopNT-in 3.0338 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.08, -16.8 APE9-dihe-na -129.39, 159.74 APE8-dihe-in -65.11, 144.15 APE8-rot-in 304.17 APE67-dihe-in -60.23, -34.65 -53.66, -41.25 APE12-dist-in 13.3065 APE11-dist-in 10.9767 APE10-dist-in 7.0684 APE9-dist-in 3.5015 K965R TPO893 TPO893 XRAY 3.41 0.201 0.223 H 344.0 314.0 0 29 29 0 [[727, 1020]] 1.0 8bup CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8P81A Q9NYV4 716 1035 1490.0 RMF:1101 Type1 Active DFGin 7.0954 14.4463 BLAminus -134.83, -178.64 59.2, 72.19 -89.53, 34.88 291.56, 80.44 -67.97, -22.73 in-in in 8.3586 Saltbr-in 3.0568 HRD-in -81.5, -42.97 59.01, 18.94 in-in-in SNCiii in-in ActLoopNT-in 2.9629 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.63, 165.61 APE9-dihe-na 67.08, 139.25 APE8-dihe-in -61.99, 152.33 APE8-rot-in 316.49 APE67-dihe-in -68.12, -20.85 -57.98, -41.98 APE12-dist-in 12.6789 APE11-dist-in 10.561 APE10-dist-in 6.5202 APE9-dist-in 3.2122 None TPO893 TPO893 XRAY 2.68 0.212 0.255 A 351.0 320.0 0 29 29 0 [[727, 1020]] 1.0 8p81 CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU2H Q9NYV4 715 1043 1490.0 RVQ:61101 Type1 Inactive DFGin 7.1243 15.3663 ABAminus -126.78, -38.9 -105.5, 92.35 -91.27, 30.22 285.75, 68.07 -78.32, -11.53 in-in in 7.7854 Saltbr-in 3.3155 HRD-in -76.93, -54.56 71.73, 6.27 in-in-in SNCiii in-in ActLoopNT-in 2.7922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.54, -42.84 APE9-dihe-na -100.7, 153.79 APE8-dihe-in -58.19, 144.22 APE8-rot-in 306.05 APE67-dihe-in -62.43, -37.08 -51.71, -42.2 APE12-dist-in 13.8509 APE11-dist-in 11.9364 APE10-dist-in 7.2084 APE9-dist-in 3.6382 K965R TPO893 TPO893 XRAY 3.13 0.193 0.217 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bu2 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU4B Q9NYV4 715 1043 1490.0 RQL:61101 Type1 Inactive DFGin 6.85 15.4476 ABAminus -129.55, -62.28 -85.09, 103.01 -99.2, 24.51 288.36, 76.72 -66.96, -36.21 in-in in 8.3567 Saltbr-in 2.9754 HRD-in -68.4, -61.77 77.35, 4.99 in-in-out SNCiio in-out ActLoopNT-in 2.9924 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.64, -39.36 APE9-dihe-na -92.3, 149.92 APE8-dihe-in -61.52, 149.36 APE8-rot-out 186.04 APE67-dihe-in -64.54, -31.54 -56.18, -38.32 APE12-dist-in 13.385 APE11-dist-in 11.5066 APE10-dist-in 6.6111 APE9-dist-in 3.4581 K965R TPO893 TPO893 XRAY 3.09 0.205 0.223 B 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bu4 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU4H Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 7.0469 15.5284 ABAminus -118.75, -57.9 -97.23, 97.83 -98.97, 29.55 288.47, 78.73 -75.71, -15.5 in-out in 8.2875 Saltbr-out 3.9063 HRD-in -79.59, -55.06 74.66, 4.8 out-in-out SNCoio in-out ActLoopNT-in 2.8791 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -121.0, -34.01 APE9-dihe-na -98.0, 156.31 APE8-dihe-in -61.54, 149.21 APE8-rot-out 67.45 APE67-dihe-in -64.95, -40.0 -58.15, -33.89 APE12-dist-in 13.8217 APE11-dist-in 12.0458 APE10-dist-in 7.1648 APE9-dist-in 3.5506 K965R TPO893 TPO893 XRAY 3.09 0.205 0.223 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu4 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU5B Q9NYV4 713 1044 1490.0 RMF:1101 Type1 Inactive DFGin 6.8015 14.7007 ABAminus -126.95, -66.04 -93.95, 105.24 -102.41, 30.18 293.69, 100.66 -84.84, -22.58 in-out in 8.3047 Saltbr-out 3.9335 HRD-out -78.59, 106.12 -94.17, 5.74 out-in-out SNCoio in-out ActLoopNT-in 2.8278 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -136.91, -22.25 APE9-dihe-na -109.89, 157.52 APE8-dihe-in -56.01, 131.78 APE8-rot-in 308.02 APE67-dihe-in -60.99, -26.61 -52.03, -40.26 APE12-dist-out 14.2801 APE11-dist-in 11.9408 APE10-dist-in 7.3604 APE9-dist-in 3.7666 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 B 344.0 332.0 0 29 29 0 [[727, 1020]] 1.0 8bu5 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU5H Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 7.0152 14.9781 ABAminus -128.46, -54.53 -90.71, 103.12 -97.22, 31.8 290.43, 81.59 -85.33, -25.69 in-in in 8.4795 Saltbr-in 3.5275 HRD-in -73.55, -49.58 63.85, -4.76 in-in-in SNCiii in-in ActLoopNT-in 2.6292 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.5, -28.02 APE9-dihe-na -97.36, 153.71 APE8-dihe-in -57.72, 135.61 APE8-rot-in 311.07 APE67-dihe-in -63.38, -27.52 -50.57, -39.59 APE12-dist-in 13.9415 APE11-dist-in 12.128 APE10-dist-in 7.2577 APE9-dist-in 3.4973 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 H 344.0 331.0 0 29 29 0 [[727, 1020]] 1.0 8bu5 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU9H Q9NYV4 715 1038 1490.0 RRC:61101 Type1 Inactive DFGin 6.8966 15.0279 ABAminus -130.72, -61.46 -86.64, 101.77 -100.72, 17.49 288.44, 80.02 -65.69, -13.23 in-in in 8.1483 Saltbr-in 3.5944 HRD-in -73.34, -52.41 71.89, 3.55 in-in-out SNCiio in-out ActLoopNT-in 2.7833 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.4, -56.59 APE9-dihe-na -80.8, 152.68 APE8-dihe-in -61.03, 143.88 APE8-rot-out 47.91 APE67-dihe-in -59.68, -32.23 -55.45, -41.09 APE12-dist-in 13.7228 APE11-dist-in 11.9439 APE10-dist-in 7.0071 APE9-dist-in 3.5232 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 H 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUAB Q9NYV4 715 1039 1490.0 RVH:1101 Type1 Inactive DFGin 6.6602 15.3703 ABAminus -132.25, -47.59 -83.62, 100.61 -101.79, 23.05 288.11, 77.38 -59.48, -33.33 in-in in 8.0717 Saltbr-in 2.9334 HRD-in -66.14, -55.51 74.2, 0.02 in-in-in SNCiii in-in ActLoopNT-in 2.9584 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.76, -47.66 APE9-dihe-na -82.97, 151.34 APE8-dihe-in -63.64, 142.13 APE8-rot-in 293.22 APE67-dihe-in -60.49, -35.73 -49.76, -42.55 APE12-dist-in 13.5676 APE11-dist-in 11.7656 APE10-dist-in 6.6656 APE9-dist-in 3.5427 K965R TPO893 TPO893 XRAY 3.193 0.202 0.225 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bua CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUAE Q9NYV4 715 1033 1490.0 RVH:1101 Type1 Inactive DFGin 6.9569 15.0827 ABAminus -126.35, -57.7 -89.06, 99.95 -100.88, 19.34 288.21, 78.03 -60.59, -33.21 in-out in 8.3642 Saltbr-out 3.6783 HRD-in -67.84, -57.25 75.2, 0.85 out-in-out SNCoio in-out ActLoopNT-in 2.9234 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -70.04, -46.21 APE9-dihe-na -79.96, 152.67 APE8-dihe-in -66.28, 142.61 APE8-rot-out 169.95 APE67-dihe-in -61.55, -33.2 -51.95, -45.85 APE12-dist-in 13.685 APE11-dist-in 12.0864 APE10-dist-in 6.7662 APE9-dist-in 3.4225 K965R TPO893 TPO893 XRAY 3.193 0.202 0.225 E 344.0 319.0 0 29 29 0 [[727, 1020]] 1.0 8bua CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUAH Q9NYV4 715 1034 1490.0 RVH:1101 Type1 Inactive DFGin 6.8833 15.4199 ABAminus -126.04, -56.2 -88.9, 101.16 -97.82, 20.48 283.52, 73.51 -61.26, -31.16 in-in in 7.9328 Saltbr-in 2.9687 HRD-in -68.56, -58.56 73.11, 1.68 in-in-out SNCiio in-out ActLoopNT-in 2.8965 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -115.42, -52.09 APE9-dihe-na -83.64, 155.3 APE8-dihe-in -61.52, 141.11 APE8-rot-in 293.24 APE67-dihe-in -60.38, -38.31 -51.83, -39.97 APE12-dist-out 14.0879 APE11-dist-in 12.2501 APE10-dist-in 7.2726 APE9-dist-in 3.5461 K965R TPO893 TPO893 XRAY 3.193 0.202 0.225 H 344.0 320.0 0 29 29 0 [[727, 1020]] 1.0 8bua CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUCB Q9NYV4 715 1041 1490.0 RKO:61101 Type1 Inactive DFGin 6.8353 15.4949 ABAminus -130.47, -49.88 -100.7, 87.88 -87.1, 28.61 287.17, 76.07 -67.87, -32.97 in-in in 8.1269 Saltbr-in 2.9277 HRD-in -72.49, -52.56 71.47, 1.89 in-in-out SNCiio in-out ActLoopNT-in 2.8266 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.68, -53.4 APE9-dihe-na -81.9, 152.03 APE8-dihe-in -63.34, 145.38 APE8-rot-out 183.29 APE67-dihe-in -65.1, -32.1 -54.44, -34.81 APE12-dist-in 13.2337 APE11-dist-in 11.4246 APE10-dist-in 6.5603 APE9-dist-in 3.6129 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8buc CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUDB Q9NYV4 715 1043 1490.0 RP9:61101 Type1 Inactive DFGin 6.8061 15.4238 ABAminus -142.15, -16.91 -106.36, 87.13 -96.45, 32.21 289.44, 76.45 -77.57, -27.46 in-in in 8.0202 Saltbr-in 3.4896 HRD-in -66.52, -51.15 74.89, 1.88 in-in-in SNCiii in-in ActLoopNT-in 2.9309 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.04, -21.52 APE9-dihe-na -109.6, 155.4 APE8-dihe-in -62.09, 142.67 APE8-rot-in 309.35 APE67-dihe-in -60.6, -25.6 -60.57, -39.4 APE12-dist-in 13.1906 APE11-dist-in 11.7357 APE10-dist-in 6.6928 APE9-dist-in 3.6946 K965R TPO893 TPO893 XRAY 3.2 0.191 0.22 B 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bud CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUDH Q9NYV4 715 1043 1490.0 RP9:61101 Type1 Inactive DFGin 6.9462 15.3566 ABAminus -136.05, -39.21 -99.68, 89.69 -94.42, 33.08 285.78, 76.86 -80.16, -27.09 in-in in 7.932 Saltbr-in 3.0948 HRD-in -68.45, -57.7 74.71, 4.44 in-in-in SNCiii in-in ActLoopNT-in 2.8947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.74, -26.44 APE9-dihe-na -108.9, 157.16 APE8-dihe-in -60.21, 144.65 APE8-rot-in 297.94 APE67-dihe-in -60.44, -27.56 -58.25, -38.75 APE12-dist-in 13.6485 APE11-dist-in 11.7344 APE10-dist-in 7.1594 APE9-dist-in 3.6555 K965R TPO893 TPO893 XRAY 3.2 0.191 0.22 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bud CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUEH Q9NYV4 715 1043 1490.0 RVU:61101 Type1 Inactive DFGin 6.9533 15.5282 ABAminus -135.4, -31.77 -104.88, 88.01 -89.97, 37.83 286.95, 75.03 -83.73, -24.85 in-in in 8.0945 Saltbr-in 3.0534 HRD-in -72.11, -58.45 75.28, 1.16 in-in-in SNCiii in-in ActLoopNT-in 2.9141 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.38, -30.92 APE9-dihe-na -101.17, 153.28 APE8-dihe-in -59.63, 146.59 APE8-rot-in 309.03 APE67-dihe-in -63.21, -32.83 -55.37, -40.46 APE12-dist-in 13.5206 APE11-dist-in 11.6573 APE10-dist-in 6.9037 APE9-dist-in 3.3499 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bue CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUIB Q9NYV4 715 1041 1490.0 RV6:1101 Type1 Inactive DFGin 6.8484 15.3849 ABAminus -131.36, -62.29 -89.48, 101.04 -94.93, 20.15 285.65, 74.39 -62.98, -21.99 in-in in 8.0628 Saltbr-in 3.2441 HRD-out -78.21, 99.43 -82.66, -35.16 in-in-in SNCiii in-in ActLoopNT-in 3.1675 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.84, -19.18 APE9-dihe-na -128.33, 156.07 APE8-dihe-in -65.63, 140.55 APE8-rot-in 297.93 APE67-dihe-in -59.87, -34.95 -53.39, -43.04 APE12-dist-in 13.3654 APE11-dist-in 10.9607 APE10-dist-in 7.2526 APE9-dist-in 4.181 K965R TPO893 TPO893 XRAY 3.5 0.184 0.221 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bui CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUIH Q9NYV4 715 1038 1490.0 RV6:1101 Type1 Inactive DFGin 6.9697 15.2814 ABAminus -131.92, -50.63 -89.53, 95.29 -98.99, 14.99 287.64, 76.53 -67.14, -30.95 in-in in 8.1508 Saltbr-in 3.2771 HRD-out -79.19, 77.36 -62.47, -39.48 in-in-in SNCiii in-in ActLoopNT-in 2.9931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.57, -18.14 APE9-dihe-na -112.45, 157.67 APE8-dihe-in -65.3, 140.25 APE8-rot-in 297.23 APE67-dihe-in -58.21, -35.12 -53.14, -43.81 APE12-dist-in 13.665 APE11-dist-in 11.5249 APE10-dist-in 7.0045 APE9-dist-in 3.8741 K965R TPO893 TPO893 XRAY 3.5 0.184 0.221 H 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bui CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BULH Q9NYV4 715 1034 1490.0 RSU:1101 Type1 Inactive DFGin 7.0023 15.3341 ABAminus -135.61, -41.73 -99.52, 91.67 -88.52, 15.79 285.0, 79.41 -60.56, -30.48 in-in in 7.861 Saltbr-in 2.9464 HRD-in -71.18, -53.58 72.73, 2.44 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.32, -27.33 APE9-dihe-na -113.19, 154.32 APE8-dihe-in -60.54, 141.61 APE8-rot-in 300.72 APE67-dihe-in -58.89, -38.82 -52.85, -42.63 APE12-dist-in 13.5001 APE11-dist-in 11.612 APE10-dist-in 7.1824 APE9-dist-in 3.8181 None TPO893 TPO893 XRAY 3.4 0.179 0.215 H 344.0 320.0 0 29 29 0 [[727, 1020]] 1.0 8bul CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUNB Q9NYV4 715 1041 1490.0 RNF:61101 Type1 Inactive DFGin 7.0092 15.2967 ABAminus -131.36, -49.43 -89.83, 91.44 -92.44, 32.63 287.3, 77.5 -75.27, -18.22 in-in in 7.7476 Saltbr-in 3.2793 HRD-in -75.67, -53.71 75.4, -0.11 in-in-in SNCiii in-in ActLoopNT-in 2.9232 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.12, -39.12 APE9-dihe-na -104.98, 151.97 APE8-dihe-in -58.93, 142.91 APE8-rot-in 279.94 APE67-dihe-in -65.42, -33.6 -55.06, -35.14 APE12-dist-in 13.3877 APE11-dist-in 11.6951 APE10-dist-in 7.099 APE9-dist-in 3.6569 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bun CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUNH Q9NYV4 715 1043 1490.0 RNF:61101 Type1 Inactive DFGin 7.0453 15.2864 ABAminus -125.24, -50.09 -100.69, 94.75 -92.24, 30.97 286.18, 71.82 -75.42, -18.26 in-in in 7.8338 Saltbr-in 3.3735 HRD-in -77.6, -54.36 73.0, -1.25 in-in-in SNCiii in-in ActLoopNT-in 2.74 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.56, -41.65 APE9-dihe-na -95.79, 153.05 APE8-dihe-in -58.87, 144.43 APE8-rot-in 305.25 APE67-dihe-in -65.98, -31.29 -55.83, -37.71 APE12-dist-in 13.7752 APE11-dist-in 11.9719 APE10-dist-in 6.9568 APE9-dist-in 3.4785 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bun CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUOB Q9NYV4 715 1040 1490.0 RLC:1101 Type1 Inactive DFGin 6.577 15.6443 ABAminus -146.64, 39.95 -136.73, 75.69 -99.12, 16.92 290.75, 79.72 -67.9, -33.68 in-in in 8.2125 Saltbr-in 2.831 HRD-in -67.45, -41.41 63.58, -11.91 in-in-in SNCiii in-in ActLoopNT-in 2.9789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.89, -24.96 APE9-dihe-na -114.96, 153.64 APE8-dihe-in -59.59, 137.04 APE8-rot-in 298.26 APE67-dihe-in -58.73, -33.95 -50.83, -38.96 APE12-dist-in 13.2777 APE11-dist-in 11.4095 APE10-dist-in 7.0434 APE9-dist-in 3.9158 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 B 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8buo CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BURE Q9NYV4 715 1040 1490.0 RQU:61101 Type1 Inactive DFGin 6.8845 15.8442 ABAminus -134.08, -49.7 -100.21, 93.56 -92.36, 24.23 284.18, 80.41 -66.46, -36.08 in-in in 8.2155 Saltbr-in 2.802 HRD-in -63.9, -48.8 70.15, 6.43 in-in-out SNCiio in-out ActLoopNT-in 2.9274 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -92.25, -40.02 APE9-dihe-na -84.05, 150.42 APE8-dihe-in -60.84, 144.54 APE8-rot-out 183.23 APE67-dihe-in -64.31, -32.85 -49.71, -40.37 APE12-dist-in 12.2442 APE11-dist-in 11.971 APE10-dist-in 6.5332 APE9-dist-in 3.8503 K965R TPO893 TPO893 XRAY 3.64 0.192 0.234 E 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8bur CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUSH Q9NYV4 715 1044 1490.0 RMX:1101 Type1 Inactive DFGin 6.901 15.0688 ABAminus -143.82, 12.24 -131.03, 98.54 -110.73, 33.01 294.28, 70.2 -74.22, -18.61 in-in in 7.9468 Saltbr-in 3.1237 HRD-in -74.26, -49.18 68.04, 9.28 in-in-in SNCiii in-in ActLoopNT-in 2.8467 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -102.73, -48.18 APE9-dihe-na -92.8, 152.41 APE8-dihe-in -59.01, 141.68 APE8-rot-in 303.45 APE67-dihe-in -64.79, -31.26 -52.5, -37.48 APE12-dist-in 13.6606 APE11-dist-in 11.9862 APE10-dist-in 7.1999 APE9-dist-in 3.7373 K965R TPO893 TPO893 XRAY 3.26 0.209 0.228 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bus CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUTB Q9NYV4 715 1039 1490.0 RQ5:61101 Type1 Inactive DFGin 7.0564 15.3959 ABAminus -130.15, -50.58 -94.08, 102.79 -101.3, 34.01 287.2, 80.24 -71.28, -33.81 in-in in 8.1776 Saltbr-in 3.454 HRD-in -68.35, -50.74 72.26, 0.96 in-in-out SNCiio in-out ActLoopNT-in 2.8548 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -102.11, -52.89 APE9-dihe-na -83.71, 152.96 APE8-dihe-in -63.18, 146.03 APE8-rot-out 183.88 APE67-dihe-in -64.84, -30.01 -53.45, -39.74 APE12-dist-in 13.1524 APE11-dist-in 11.7525 APE10-dist-in 6.8757 APE9-dist-in 3.6644 K965R TPO893 TPO893 XRAY 3.25 0.198 0.217 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8but CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUTH Q9NYV4 715 1043 1490.0 RQ5:61101 Type1 Inactive DFGin 7.0927 15.4205 ABAminus -128.56, -49.4 -93.56, 100.15 -99.66, 30.54 282.78, 78.32 -73.44, -31.71 in-in in 8.0901 Saltbr-in 3.5145 HRD-in -72.59, -52.14 71.01, -0.2 in-in-in SNCiii in-in ActLoopNT-in 2.7456 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -103.31, -52.45 APE9-dihe-na -84.96, 155.97 APE8-dihe-in -63.11, 145.04 APE8-rot-in 301.85 APE67-dihe-in -65.27, -28.99 -54.91, -40.74 APE12-dist-in 13.688 APE11-dist-in 12.0303 APE10-dist-in 7.147 APE9-dist-in 3.4886 K965R TPO893 TPO893 XRAY 3.25 0.198 0.217 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8but CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 7NXKA Q9NYV4 715 1040 1490.0 UUB:2000 Type1 Inactive DFGin 7.3995 15.4871 ABAminus -95.46, -72.72 -129.88, 136.0 -106.22, 48.24 290.77, 75.67 -65.42, -30.99 in-none in 8.908 Saltbr-none 999.0 HRD-out -77.5, 146.77 -128.84, 17.49 none-in-out SNCnio in-out ActLoopNT-in 2.9696 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.63, -48.96 APE9-dihe-na -98.39, 153.96 APE8-dihe-in -58.36, 147.85 APE8-rot-out 42.54 APE67-dihe-in -71.34, -26.96 -59.32, -29.48 APE12-dist-in 12.8425 APE11-dist-in 11.1162 APE10-dist-in 6.7497 APE9-dist-in 3.4451 None TPO893 TPO893 XRAY 3.0 0.222 0.264 A 351.0 322.0 4 29 29 0 [[727, 1020]] 1.0 7nxk CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 9FMRE Q9NYV4 714 1042 1490.0 RMF:61101 Type1 Inactive DFGin 6.7935 14.6403 ABAminus -113.83, -79.52 -84.15, 118.47 -115.27, 16.16 293.54, 100.02 -64.02, -34.33 in-out in 9.6335 Saltbr-out 3.6123 HRD-out -79.17, 82.22 -59.96, 8.89 out-in-out SNCoio in-out ActLoopNT-in 3.0256 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -148.14, -27.51 APE9-dihe-na -104.44, 148.12 APE8-dihe-in -51.45, 137.55 APE8-rot-in 306.02 APE67-dihe-in -70.5, -21.3 -54.61, -36.19 APE12-dist-out 14.2984 APE11-dist-in 12.2112 APE10-dist-in 7.469 APE9-dist-in 3.7666 None TPO893 TPO893 XRAY 3.9 0.209 0.25 E 351.0 329.0 0 29 29 0 [[727, 1020]] 1.0 9fmr CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 9FMRH Q9NYV4 714 1044 1490.0 RMF:61101 Type1 Inactive DFGin 6.8012 14.6033 ABAminus -113.95, -78.4 -84.85, 124.02 -118.87, 17.95 291.29, 89.7 -63.88, -35.4 in-in in 8.5917 Saltbr-in 3.5517 HRD-in -72.47, -40.65 59.82, 5.57 in-in-in SNCiii in-in ActLoopNT-in 2.9439 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.74, -27.71 APE9-dihe-na -103.25, 148.34 APE8-dihe-in -51.07, 136.63 APE8-rot-in 306.14 APE67-dihe-in -69.99, -21.15 -54.39, -34.8 APE12-dist-in 13.8232 APE11-dist-in 12.0979 APE10-dist-in 7.2545 APE9-dist-in 3.6076 None TPO893 TPO893 XRAY 3.9 0.209 0.25 H 351.0 331.0 0 29 29 0 [[727, 1020]] 1.0 9fmr CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 4CXAA Q9NYV4 718 1050 1490.0 ANP:2051 ATPlike Inactive DFGin 6.4362 15.0223 BLAminus -127.47, 178.63 59.83, 84.78 -103.34, 39.58 291.64, 72.71 -78.99, -14.54 in-in in 8.1775 Saltbr-in 2.5134 HRD-in -89.68, -50.66 63.81, 17.68 in-in-out SNCiio in-out ActLoopNT-in 2.7933 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.43, 159.2 APE9-dihe-na 63.92, 139.76 APE8-dihe-in -56.37, 145.01 APE8-rot-out 63.76 APE67-dihe-in -64.68, -22.99 -55.23, -40.79 APE12-dist-in 13.2123 APE11-dist-in 11.6623 APE10-dist-in 7.3626 APE9-dist-in 3.5055 None TPO893 TPO893 XRAY 3.15 0.224 0.279 A 340.0 330.0 3 29 28 1 [[727, 1020]] 1.0 4cxa CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 4NSTA Q9NYV4 716 1046 1490.0 ADP:1101 ATPlike Inactive DFGin 6.9783 15.1109 BLAminus -127.54, 179.84 60.58, 76.06 -95.3, 23.79 283.73, 86.71 -65.43, -16.77 in-in in 8.9881 Saltbr-in 3.0309 HRD-in -82.28, -56.37 71.8, 9.39 in-in-out SNCiio in-out ActLoopNT-in 2.9558 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.59, 153.12 APE9-dihe-na 76.09, 132.29 APE8-dihe-in -60.41, 149.83 APE8-rot-out 85.48 APE67-dihe-in -64.83, -28.79 -60.07, -39.7 APE12-dist-in 13.2466 APE11-dist-in 11.2727 APE10-dist-in 6.9953 APE9-dist-in 3.4606 None TPO893 TPO893 XRAY 2.2 0.198 0.24 A 351.0 323.0 8 29 29 0 [[727, 1020]] 1.0 4nst CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 4NSTC Q9NYV4 717 1045 1490.0 ADP:1101 ATPlike Inactive DFGin 6.9718 15.1681 BLAminus -122.49, -178.57 55.97, 75.42 -92.86, 20.68 283.24, 86.31 -56.98, -20.08 in-in in 8.8631 Saltbr-in 2.9569 HRD-in -69.12, -51.54 66.96, 15.75 in-in-out SNCiio in-out ActLoopNT-in 2.9277 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.74, 152.42 APE9-dihe-na 82.09, 126.12 APE8-dihe-in -62.22, 152.62 APE8-rot-out 78.32 APE67-dihe-in -63.16, -30.08 -57.73, -42.25 APE12-dist-in 13.2024 APE11-dist-in 11.2673 APE10-dist-in 6.9416 APE9-dist-in 3.7053 None TPO893 TPO893 XRAY 2.2 0.198 0.24 C 351.0 318.0 11 29 28 1 [[727, 1020]] 1.0 4nst CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 4UN0C Q9NYV4 719 1036 1490.0 No_ligand No_ligand Inactive DFGin 7.2318 15.5034 BLAminus -124.23, -178.57 61.68, 76.73 -100.84, 26.92 286.01, 6.79 -65.68, -44.77 in-none in 8.9953 Saltbr-none 999.0 HRD-in -69.99, -50.49 63.23, 23.44 none-in-out SNCnio in-out ActLoopNT-in 2.9363 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -139.84, 155.57 APE9-dihe-na 72.34, -14.08 APE8-dihe-out 67.52, 158.6 APE8-rot-out 70.66 APE67-dihe-in -58.83, -37.69 -56.4, -50.16 APE12-dist-in 13.1272 APE11-dist-in 10.7644 APE10-dist-in 7.9437 APE9-dist-in 3.9269 None TPO893 TPO893 XRAY 3.15 0.217 0.271 C 326.0 309.0 9 29 29 0 [[727, 1020]] 1.0 4un0 CMGC_CDK12_HUMAN CMGC 2.2e-84 289.2 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 4UN0D Q9NYV4 723 1024 1490.0 No_ligand No_ligand Inactive DFGin 7.1953 15.4696 BLAminus -123.96, -178.26 62.11, 76.94 -101.1, 26.4 286.66, 6.77 -66.07, -44.8 in-none in 8.9588 Saltbr-none 999.0 HRD-in -70.01, -50.55 63.3, 23.26 none-in-out SNCnio in-out ActLoopNT-in 2.8072 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -139.6, 156.23 APE9-dihe-na 75.54, -12.58 APE8-dihe-out 66.76, 157.7 APE8-rot-out 70.35 APE67-dihe-in -58.41, -37.99 -56.68, -49.87 APE12-dist-in 13.2106 APE11-dist-in 11.101 APE10-dist-in 7.9718 APE9-dist-in 3.9556 None TPO893 TPO893 XRAY 3.15 0.217 0.271 D 326.0 277.0 25 29 24 5 [[727, 1020]] 1.0 4un0 CMGC_CDK12_HUMAN CMGC 2.2e-84 289.2 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 4CXAC Q9NYV4 718 1048 1490.0 No_ligand No_ligand Inactive DFGin 7.1995 15.2477 BLAminus -126.07, 177.23 58.72, 82.97 -102.36, 37.62 286.53, 69.22 -80.81, -13.97 in-none in 8.0455 Saltbr-none 999.0 HRD-in -86.15, -47.73 62.33, 17.56 none-in-out SNCnio in-out ActLoopNT-in 3.0475 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.86, 161.73 APE9-dihe-na 68.73, 142.31 APE8-dihe-in -55.95, 146.27 APE8-rot-out 63.52 APE67-dihe-in -66.87, -27.84 -54.72, -39.98 APE12-dist-in 13.1798 APE11-dist-in 11.907 APE10-dist-in 7.4808 APE9-dist-in 3.5773 None TPO893 TPO893 XRAY 3.15 0.224 0.279 C 340.0 331.0 0 29 29 0 [[727, 1020]] 1.0 4cxa CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU2E Q9NYV4 715 1039 1490.0 No_ligand No_ligand Inactive DFGin 7.3788 15.5698 BLAminus -136.39, 179.92 48.57, 72.52 -89.87, 33.71 279.3, 90.07 -78.07, -11.47 in-in in 7.9107 Saltbr-in 3.1471 HRD-in -74.54, -52.71 71.43, 6.76 in-in-out SNCiio in-out ActLoopNT-in 2.8692 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.65, -39.48 APE9-dihe-na -100.87, 155.56 APE8-dihe-in -58.32, 146.43 APE8-rot-out 175.64 APE67-dihe-in -62.37, -35.72 -53.25, -43.67 APE12-dist-in 13.3936 APE11-dist-in 12.5707 APE10-dist-in 7.1487 APE9-dist-in 3.7382 K965R TPO893 TPO893 XRAY 3.13 0.193 0.217 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu2 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUDE Q9NYV4 715 1043 1490.0 No_ligand No_ligand Inactive DFGin 7.2716 15.453 BLAminus -143.83, -177.07 47.13, 79.14 -96.0, 35.58 285.18, 78.34 -74.8, -28.12 in-in in 8.105 Saltbr-in 3.0752 HRD-in -66.78, -51.99 75.75, 3.43 in-in-out SNCiio in-out ActLoopNT-in 2.9854 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -100.45, -19.67 APE9-dihe-na -95.18, 153.43 APE8-dihe-in -60.73, 146.92 APE8-rot-out 173.58 APE67-dihe-in -62.46, -23.72 -59.64, -41.84 APE12-dist-in 13.0579 APE11-dist-in 12.4969 APE10-dist-in 6.7722 APE9-dist-in 3.4044 K965R TPO893 TPO893 XRAY 3.2 0.191 0.22 E 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bud CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUGE Q9NYV4 715 1039 1490.0 No_ligand No_ligand Inactive DFGin 7.5082 15.7435 BLAminus -142.95, -165.93 46.31, 64.06 -92.32, 17.1 280.22, 84.99 -61.9, -35.84 in-in in 8.2122 Saltbr-in 3.1127 HRD-in -63.09, -51.61 71.91, 6.47 in-in-out SNCiio in-out ActLoopNT-in 2.9558 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -74.97, -44.52 APE9-dihe-na -69.42, 151.3 APE8-dihe-in -61.28, 146.55 APE8-rot-out 168.8 APE67-dihe-in -63.35, -29.72 -54.01, -46.01 APE12-dist-in 13.2222 APE11-dist-in 12.7218 APE10-dist-in 6.9462 APE9-dist-in 3.4313 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bug CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 6B3EA Q9NYV4 717 1036 1490.0 CJM:1102 Type1 Inactive DFGin 7.202 14.7664 BLAminus -121.7, 178.92 59.35, 79.81 -95.65, 26.66 285.79, 81.49 -61.82, -29.55 in-in in 8.6992 Saltbr-in 3.05 HRD-in -76.48, -54.37 70.53, 12.96 in-in-out SNCiio in-out ActLoopNT-in 2.9145 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.0, 155.78 APE9-dihe-na 76.06, 131.42 APE8-dihe-in -60.49, 145.1 APE8-rot-out 86.32 APE67-dihe-in -63.58, -25.36 -47.54, -46.44 APE12-dist-in 13.3552 APE11-dist-in 11.458 APE10-dist-in 6.9768 APE9-dist-in 3.4966 None TPO893 TPO893 XRAY 3.06 0.191 0.212 A 320.0 310.0 10 29 29 0 [[727, 1020]] 1.0 6b3e CMGC_CDK12_HUMAN CMGC 2e-84 289.3 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 6B3EC Q9NYV4 719 1036 1490.0 CJM:1103 Type1 Inactive DFGin 7.173 14.6207 BLAminus -121.27, -179.9 57.69, 80.64 -96.21, 26.0 285.96, 80.56 -59.62, -30.89 in-in in 8.5283 Saltbr-in 2.8376 HRD-in -74.96, -53.91 69.51, 14.07 in-in-out SNCiio in-out ActLoopNT-in 2.8936 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.93, 154.64 APE9-dihe-na 78.03, 130.48 APE8-dihe-in -61.1, 145.82 APE8-rot-out 85.07 APE67-dihe-in -62.57, -25.75 -47.61, -47.19 APE12-dist-in 13.2674 APE11-dist-in 11.359 APE10-dist-in 6.9435 APE9-dist-in 3.5617 None TPO893 TPO893 XRAY 3.06 0.191 0.212 C 320.0 308.0 10 29 29 0 [[727, 1020]] 1.0 6b3e CMGC_CDK12_HUMAN CMGC 2e-84 289.3 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 5ACBC Q9NYV4 716 1040 1490.0 5I1:2000 Type1 Inactive DFGin 7.4424 15.98 BLAminus -120.77, 171.13 69.09, 68.44 -91.07, 27.42 288.67, 78.45 -57.05, -52.5 in-in in 8.3689 Saltbr-in 2.8783 HRD-in -75.39, -52.07 67.69, 20.88 in-in-out SNCiio in-out ActLoopNT-in 2.8043 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.05, 158.72 APE9-dihe-na 71.72, 133.31 APE8-dihe-in -62.63, 141.8 APE8-rot-out 192.05 APE67-dihe-in -62.93, -27.37 -47.97, -41.23 APE12-dist-in 13.6417 APE11-dist-in 11.6664 APE10-dist-in 7.3938 APE9-dist-in 3.5299 None TPO893 TPO893 XRAY 2.7 0.223 0.262 C 340.0 325.0 0 29 29 0 [[727, 1020]] 1.0 5acb CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 5ACBD Q9NYV4 718 1044 1490.0 5I1:2000 Type1 Inactive DFGin 7.4517 16.0111 BLAminus -121.14, 171.65 68.87, 69.17 -92.34, 27.19 288.77, 78.24 -58.4, -50.08 in-in in 8.349 Saltbr-in 2.8748 HRD-in -75.87, -51.87 67.36, 21.14 in-in-out SNCiio in-out ActLoopNT-in 2.8109 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.18, 158.62 APE9-dihe-na 71.07, 133.26 APE8-dihe-in -63.22, 142.55 APE8-rot-out 191.44 APE67-dihe-in -63.33, -26.97 -48.15, -41.58 APE12-dist-in 13.6981 APE11-dist-in 11.7681 APE10-dist-in 7.4862 APE9-dist-in 3.5674 None TPO893 TPO893 XRAY 2.7 0.223 0.262 D 340.0 320.0 7 29 26 3 [[727, 1020]] 1.0 5acb CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 9JK1A Q9NYV4 717 1039 1490.0 A1EB3:1202 Type1 Inactive DFGin 7.136 16.1944 BLAminus -133.53, 173.61 54.27, 71.41 -88.96, 16.92 270.96, 77.73 -63.15, -30.31 in-in in 8.4971 Saltbr-in 3.2847 HRD-in -81.17, -44.88 64.66, 14.44 in-in-out SNCiio in-out ActLoopNT-in 2.8569 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.0, -26.54 APE9-dihe-na -103.25, 143.89 APE8-dihe-in -52.76, 144.9 APE8-rot-out 169.48 APE67-dihe-in -66.06, -18.64 -58.71, -34.25 APE12-dist-in 13.7501 APE11-dist-in 12.2647 APE10-dist-in 7.1765 APE9-dist-in 3.888 None TPO893 TPO893 XRAY 2.72 0.249 0.267 A 340.0 311.0 12 29 27 2 [[727, 1020]] 1.0 9jk1 CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 9JK1B Q9NYV4 715 1039 1490.0 A1EB3:1101 Type1 Inactive DFGin 6.9737 15.7959 BLAminus -131.76, 174.62 55.08, 70.72 -88.19, 16.31 271.01, 79.18 -62.74, -29.13 in-in in 8.5172 Saltbr-in 3.0362 HRD-in -81.5, -44.39 65.05, 13.56 in-in-out SNCiio in-out ActLoopNT-in 3.1501 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.88, -41.9 APE9-dihe-na -106.09, 143.29 APE8-dihe-in -52.94, 146.84 APE8-rot-out 167.82 APE67-dihe-in -65.97, -16.6 -59.29, -37.44 APE12-dist-in 13.6164 APE11-dist-in 11.5844 APE10-dist-in 7.2432 APE9-dist-in 3.6611 None TPO893 TPO893 XRAY 2.72 0.249 0.267 B 340.0 315.0 10 29 29 0 [[727, 1020]] 1.0 9jk1 CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 6TD3B Q9NYV4 715 1047 1490.0 RC8:1101 Type1 Inactive DFGin 7.0715 15.3763 BLAminus -144.85, 177.87 66.18, 66.81 -86.27, 29.11 284.0, 81.86 -68.57, -26.95 in-in in 7.9403 Saltbr-in 3.0983 HRD-in -75.0, -46.5 66.33, 3.67 in-in-out SNCiio in-out ActLoopNT-in 2.9625 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.74, 152.33 APE9-dihe-na 70.44, 153.31 APE8-dihe-in -72.7, 152.08 APE8-rot-out 190.09 APE67-dihe-in -62.32, -35.85 -49.81, -38.44 APE12-dist-in 13.58 APE11-dist-in 10.9935 APE10-dist-in 7.1532 APE9-dist-in 3.6429 K965R TPO893 TPO893 XRAY 3.46 0.195 0.22 B 344.0 333.0 0 29 29 0 [[727, 1020]] 1.0 6td3 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 6TD3H Q9NYV4 715 1047 1490.0 RC8:1101 Type1 Inactive DFGin 7.0079 15.0671 BLAminus -125.85, 165.87 77.73, 76.18 -92.06, 29.13 290.22, 73.9 -71.24, -38.15 in-in in 7.8983 Saltbr-in 3.0731 HRD-in -75.01, -45.87 63.18, 11.24 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -152.2, 169.13 APE9-dihe-na 75.43, 19.72 APE8-dihe-out 60.33, 162.48 APE8-rot-out 98.13 APE67-dihe-in -64.24, -27.06 -78.21, -44.67 APE12-dist-in 13.9046 APE11-dist-in 11.9021 APE10-dist-in 7.407 APE9-dist-in 3.189 K965R TPO893 TPO893 XRAY 3.46 0.195 0.22 H 344.0 333.0 0 29 29 0 [[727, 1020]] 1.0 6td3 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU1E Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 7.0678 15.2145 BLAminus -136.12, -177.54 44.75, 87.14 -99.51, 30.27 285.35, 73.68 -68.31, -25.33 in-in in 7.7936 Saltbr-in 3.0999 HRD-in -77.94, -49.77 74.02, -0.64 in-in-out SNCiio in-out ActLoopNT-in 2.6913 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.97, -45.94 APE9-dihe-na -80.52, 149.74 APE8-dihe-in -60.97, 145.17 APE8-rot-out 178.02 APE67-dihe-in -66.77, -27.56 -51.22, -43.09 APE12-dist-in 13.0179 APE11-dist-in 12.2266 APE10-dist-in 6.9915 APE9-dist-in 3.5494 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 E 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu1 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU4E Q9NYV4 715 1039 1490.0 RQL:61101 Type1 Inactive DFGin 7.468 15.54 BLAminus -141.1, 177.81 60.96, 67.17 -93.67, 20.14 286.75, 91.51 -68.13, -33.02 in-out in 8.589 Saltbr-out 5.3781 HRD-in -65.76, -60.59 77.41, 5.82 out-in-out SNCoio in-out ActLoopNT-in 3.0295 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -92.44, -31.45 APE9-dihe-na -85.2, 150.66 APE8-dihe-in -60.73, 147.65 APE8-rot-out 173.82 APE67-dihe-in -63.61, -27.41 -58.33, -41.33 APE12-dist-in 13.0819 APE11-dist-in 12.5962 APE10-dist-in 6.8982 APE9-dist-in 3.368 K965R TPO893 TPO893 XRAY 3.09 0.205 0.223 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu4 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU6E Q9NYV4 715 1038 1490.0 RQE:61101 Type1 Inactive DFGin 6.9042 14.7933 BLAminus -142.16, 173.3 46.61, 77.13 -86.78, 22.75 290.79, 69.64 -59.06, -38.89 in-out in 8.4663 Saltbr-out 3.7793 HRD-in -71.31, -54.36 76.0, -0.16 out-in-out SNCoio in-out ActLoopNT-in 2.9818 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -121.41, -43.86 APE9-dihe-na -68.68, 149.74 APE8-dihe-in -53.47, 142.92 APE8-rot-out 167.33 APE67-dihe-in -57.01, -34.74 -57.51, -41.34 APE12-dist-in 13.1034 APE11-dist-in 13.0819 APE10-dist-in 7.1799 APE9-dist-in 3.5468 K965R TPO893 TPO893 XRAY 3.45 0.219 0.249 E 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bu6 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU7E Q9NYV4 715 1043 1490.0 RS5:1101 Type1 Inactive DFGin 6.9129 15.3311 BLAminus -151.87, 179.81 58.39, 58.15 -75.44, 35.18 288.34, 71.23 -65.18, -38.03 in-in in 7.7566 Saltbr-in 2.771 HRD-in -65.82, -48.21 71.8, 2.22 in-in-out SNCiio in-out ActLoopNT-in 2.8804 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -76.27, -35.49 APE9-dihe-na -79.69, 146.79 APE8-dihe-in -61.33, 142.24 APE8-rot-out 178.46 APE67-dihe-in -63.9, -29.29 -50.85, -42.32 APE12-dist-in 12.5269 APE11-dist-in 12.3359 APE10-dist-in 6.449 APE9-dist-in 3.4892 K965R TPO893 TPO893 XRAY 3.245 0.193 0.219 E 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bu7 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU9E Q9NYV4 715 1039 1490.0 RRC:61101 Type1 Inactive DFGin 6.9943 15.2956 BLAminus -144.01, 174.3 58.02, 76.59 -92.29, 23.22 284.15, 79.53 -66.56, -16.01 in-in in 7.9265 Saltbr-in 2.9785 HRD-in -72.29, -52.87 75.22, 4.09 in-in-out SNCiio in-out ActLoopNT-in 2.9527 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -79.11, -41.8 APE9-dihe-na -74.19, 150.88 APE8-dihe-in -62.82, 143.67 APE8-rot-out 166.93 APE67-dihe-in -61.65, -28.3 -55.31, -42.74 APE12-dist-in 13.0026 APE11-dist-in 12.7132 APE10-dist-in 6.8922 APE9-dist-in 3.4751 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUBB Q9NYV4 715 1041 1490.0 RNU:61101 Type1 Inactive DFGin 7.183 15.8614 BLAminus -140.81, -179.71 59.34, 42.69 -57.7, -43.03 281.93, 72.19 -135.84, 169.59 in-in in 7.8158 Saltbr-in 3.0301 HRD-out -85.59, 106.33 -67.25, -35.7 in-out-out SNCioo out-out ActLoopNT-out 15.0827 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -58.9, -41.94 APE9-dihe-na -63.9, -43.28 APE8-dihe-out -57.35, -36.53 APE8-rot-in 303.78 APE67-dihe-in -55.9, -22.59 -60.27, -40.25 APE12-dist-in 10.517 APE11-dist-in 13.5215 APE10-dist-out 17.3786 APE9-dist-out 11.733 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bub CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUBE Q9NYV4 715 1043 1490.0 RNU:61101 Type1 Inactive DFGin 7.1209 15.7177 BLAminus -151.03, 179.83 54.33, 46.25 -61.28, -40.39 279.04, 68.48 -138.85, 169.0 in-in in 8.2609 Saltbr-in 2.9133 HRD-out -90.61, 99.83 -68.22, -35.13 in-out-out SNCioo out-out ActLoopNT-out 14.6238 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -60.24, -43.43 APE9-dihe-na -66.88, -44.0 APE8-dihe-out -57.36, -41.95 APE8-rot-in 294.1 APE67-dihe-in -53.67, -21.91 -61.1, -39.92 APE12-dist-in 10.606 APE11-dist-out 14.7928 APE10-dist-out 17.9151 APE9-dist-out 11.2983 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 E 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bub CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUCE Q9NYV4 715 1039 1490.0 RKO:61101 Type1 Inactive DFGin 7.2362 15.3346 BLAminus -141.04, 176.79 52.98, 78.31 -91.94, 30.22 286.84, 76.41 -65.41, -31.19 in-in in 7.9609 Saltbr-in 2.9083 HRD-in -69.25, -49.18 71.49, 1.27 in-in-out SNCiio in-out ActLoopNT-in 2.8699 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -94.07, -41.15 APE9-dihe-na -76.31, 151.65 APE8-dihe-in -63.11, 145.53 APE8-rot-out 179.86 APE67-dihe-in -66.95, -27.99 -55.33, -37.54 APE12-dist-in 12.9962 APE11-dist-in 12.5405 APE10-dist-in 6.8001 APE9-dist-in 3.4636 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8buc CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUEE Q9NYV4 715 1039 1490.0 RVU:61101 Type1 Inactive DFGin 7.242 15.4962 BLAminus -141.72, -174.7 47.09, 73.46 -90.8, 38.01 284.87, 78.5 -78.36, -22.84 in-in in 7.9834 Saltbr-in 3.3242 HRD-in -72.61, -56.11 78.07, 3.62 in-in-out SNCiio in-out ActLoopNT-in 2.8628 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -101.94, -25.35 APE9-dihe-na -96.92, 153.79 APE8-dihe-in -59.83, 147.51 APE8-rot-out 172.74 APE67-dihe-in -64.75, -28.9 -55.27, -41.29 APE12-dist-in 12.9803 APE11-dist-in 12.541 APE10-dist-in 7.0055 APE9-dist-in 3.3709 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bue CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUFE Q9NYV4 715 1043 1490.0 RW6:61101 Type1 Inactive DFGin 7.2357 15.6133 BLAminus -139.81, -179.98 50.46, 82.76 -97.71, 35.51 286.32, 76.93 -72.96, -20.08 in-in in 8.2072 Saltbr-in 3.0835 HRD-in -73.52, -52.81 75.99, 1.49 in-in-out SNCiio in-out ActLoopNT-in 3.1387 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -94.42, -47.71 APE9-dihe-na -72.58, 149.04 APE8-dihe-in -62.45, 149.79 APE8-rot-out 175.62 APE67-dihe-in -64.49, -29.41 -54.77, -42.48 APE12-dist-in 12.6293 APE11-dist-in 12.3452 APE10-dist-in 6.6156 APE9-dist-in 3.2815 K965R TPO893 TPO893 XRAY 3.3 0.185 0.22 E 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8buf CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUHE Q9NYV4 715 1034 1490.0 RR9:61101 Type1 Inactive DFGin 7.1857 15.7288 BLAminus -148.68, -172.98 46.52, 61.7 -84.29, 18.93 287.47, 71.85 -64.36, -25.08 in-in in 8.2922 Saltbr-in 3.1458 HRD-in -67.53, -47.52 70.08, 2.73 in-in-out SNCiio in-out ActLoopNT-in 2.9549 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -76.87, -40.28 APE9-dihe-na -73.29, 157.3 APE8-dihe-in -67.11, 147.48 APE8-rot-out 173.32 APE67-dihe-in -62.13, -36.27 -57.69, -39.06 APE12-dist-in 13.3694 APE11-dist-in 12.874 APE10-dist-in 7.0861 APE9-dist-in 3.4867 K965R TPO893 TPO893 XRAY 3.79 0.189 0.232 E 344.0 320.0 0 29 29 0 [[727, 1020]] 1.0 8buh CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUIE Q9NYV4 715 1039 1490.0 RV6:1101 Type1 Inactive DFGin 7.5392 15.5582 BLAminus -143.87, -178.18 39.61, 79.76 -92.26, 22.29 284.74, 80.02 -58.61, -17.16 in-out in 8.1098 Saltbr-out 3.7147 HRD-out -75.62, 149.49 -131.37, 158.61 out-in-out SNCoio in-out ActLoopNT-in 3.1665 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -99.18, -17.3 APE9-dihe-na -88.48, 155.1 APE8-dihe-in -64.43, 139.92 APE8-rot-out 15.61 APE67-dihe-in -61.18, -34.77 -50.17, -41.15 APE12-dist-in 13.0189 APE11-dist-in 12.9143 APE10-dist-in 7.0194 APE9-dist-out 6.0272 K965R TPO893 TPO893 XRAY 3.5 0.184 0.221 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bui CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUJE Q9NYV4 715 1043 1490.0 RUW:1101 Type1 Inactive DFGin 7.4026 15.5591 BLAminus -141.86, -179.96 50.47, 61.92 -80.29, 20.39 278.49, 79.05 -71.07, 143.46 in-out in 7.788 Saltbr-out 4.3749 HRD-in -62.58, -56.77 78.09, -0.63 out-in-in SNCoii in-in ActLoopNT-in 3.0989 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.26, -45.94 APE9-dihe-na -81.75, 154.86 APE8-dihe-in -61.95, 146.07 APE8-rot-in 291.01 APE67-dihe-in -60.95, -32.29 -58.05, -37.51 APE12-dist-in 12.7922 APE11-dist-in 12.1761 APE10-dist-in 7.0857 APE9-dist-in 3.4301 K965R TPO893 TPO893 XRAY 3.62 0.164 0.206 E 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8buj CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUKE Q9NYV4 715 1039 1490.0 RWE:61101 Type1 Inactive DFGin 7.1266 15.2054 BLAminus -148.82, 179.05 51.44, 70.31 -90.34, 37.33 288.85, 69.46 -77.88, -21.75 in-in in 8.1145 Saltbr-in 2.9551 HRD-in -69.03, -55.19 75.3, 6.2 in-in-out SNCiio in-out ActLoopNT-in 3.0685 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -77.16, -37.78 APE9-dihe-na -75.17, 151.97 APE8-dihe-in -63.51, 147.07 APE8-rot-out 163.95 APE67-dihe-in -64.24, -27.64 -56.09, -42.19 APE12-dist-in 12.8427 APE11-dist-in 12.4198 APE10-dist-in 6.5654 APE9-dist-in 3.319 K965R TPO893 TPO893 XRAY 3.41 0.186 0.21 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8buk CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUNE Q9NYV4 715 1039 1490.0 RNF:61101 Type1 Inactive DFGin 7.2173 15.3129 BLAminus -143.55, -179.06 50.55, 77.42 -92.12, 34.85 285.27, 76.47 -72.26, -18.51 in-in in 7.8237 Saltbr-in 3.0461 HRD-in -77.13, -53.65 75.0, -0.22 in-in-out SNCiio in-out ActLoopNT-in 2.9239 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.31, -34.23 APE9-dihe-na -92.08, 151.91 APE8-dihe-in -57.84, 145.99 APE8-rot-out 175.35 APE67-dihe-in -65.98, -29.37 -55.72, -38.5 APE12-dist-in 13.1801 APE11-dist-in 12.6112 APE10-dist-in 7.008 APE9-dist-in 3.4323 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bun CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUOE Q9NYV4 715 1040 1490.0 RLC:1101 Type1 Inactive DFGin 6.9418 15.6202 BLAminus -143.37, -172.35 44.48, 74.17 -91.23, 22.68 280.06, 81.2 -62.03, -28.06 in-in in 8.0683 Saltbr-in 3.0558 HRD-out -76.67, 113.14 -91.39, -21.48 in-in-in SNCiii in-in ActLoopNT-in 2.8935 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.19, -25.24 APE9-dihe-na -90.88, 153.8 APE8-dihe-in -61.01, 138.91 APE8-rot-in 296.79 APE67-dihe-in -57.07, -33.65 -55.69, -42.2 APE12-dist-in 12.5157 APE11-dist-in 12.5542 APE10-dist-in 6.8393 APE9-dist-in 3.7348 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 E 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8buo CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUPB Q9NYV4 715 1027 1490.0 RWN:61101 Type1 Inactive DFGin 7.3764 16.2917 BLAminus -145.67, -178.63 51.5, 56.05 -75.52, 21.8 268.89, 78.21 -77.2, 158.24 in-in in 7.988 Saltbr-in 3.5467 HRD-out -85.14, 78.87 -56.17, -33.42 in-in-in SNCiii in-in ActLoopNT-in 2.9459 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.18, -2.81 APE9-dihe-na -129.4, 158.55 APE8-dihe-in -65.53, 143.29 APE8-rot-in 297.85 APE67-dihe-in -63.16, -33.23 -55.07, -39.7 APE12-dist-in 12.6261 APE11-dist-in 11.3253 APE10-dist-in 6.9551 APE9-dist-in 4.0747 K965R TPO893 TPO893 XRAY 3.41 0.201 0.223 B 344.0 313.0 0 29 29 0 [[727, 1020]] 1.0 8bup CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUPE Q9NYV4 715 1027 1490.0 RWN:61101 Type1 Inactive DFGin 7.3717 15.5461 BLAminus -147.42, 179.7 52.21, 60.23 -77.56, 28.73 281.63, 90.36 -71.43, -13.64 in-in in 8.0342 Saltbr-in 3.2385 HRD-out -86.98, 107.75 -88.22, 168.06 in-in-out SNCiio in-out ActLoopNT-in 2.8945 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -126.76, -4.83 APE9-dihe-na -127.6, 153.97 APE8-dihe-in -68.53, 144.26 APE8-rot-out 182.45 APE67-dihe-in -60.96, -31.45 -55.15, -40.88 APE12-dist-in 12.5226 APE11-dist-in 11.3157 APE10-dist-in 6.9568 APE9-dist-out 6.0416 K965R TPO893 TPO893 XRAY 3.41 0.201 0.223 E 344.0 313.0 0 29 29 0 [[727, 1020]] 1.0 8bup CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUQB Q9NYV4 715 1039 1490.0 RQ9:61101 Type1 Inactive DFGin 6.9128 15.3011 BLAminus -151.69, -179.79 53.5, 72.83 -94.44, 24.81 291.0, 75.32 -66.25, -27.07 in-in in 8.2723 Saltbr-in 3.3021 HRD-in -68.63, -54.73 77.99, 1.83 in-in-out SNCiio in-out ActLoopNT-in 2.9427 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.29, -38.77 APE9-dihe-na -81.13, 155.19 APE8-dihe-in -64.33, 147.28 APE8-rot-out 195.9 APE67-dihe-in -60.12, -28.17 -56.8, -43.77 APE12-dist-in 13.5591 APE11-dist-in 12.0036 APE10-dist-in 6.4297 APE9-dist-in 3.5058 K965R TPO893 TPO893 XRAY 3.2 0.196 0.216 B 344.0 321.0 4 29 29 0 [[727, 1020]] 1.0 8buq CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUQE Q9NYV4 715 1027 1490.0 RQ9:61101 Type1 Inactive DFGin 7.3625 15.3415 BLAminus -149.68, 178.7 52.88, 71.39 -93.43, 23.22 287.54, 76.39 -69.29, -26.75 in-in in 8.1446 Saltbr-in 3.1498 HRD-in -69.4, -56.77 77.16, 3.04 in-in-out SNCiio in-out ActLoopNT-in 3.0159 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -114.18, -38.9 APE9-dihe-na -82.51, 153.34 APE8-dihe-in -63.97, 150.36 APE8-rot-out 173.3 APE67-dihe-in -60.97, -26.14 -55.24, -44.87 APE12-dist-in 13.1923 APE11-dist-in 12.4633 APE10-dist-in 6.9357 APE9-dist-in 3.3361 K965R TPO893 TPO893 XRAY 3.2 0.196 0.216 E 344.0 313.0 0 29 29 0 [[727, 1020]] 1.0 8buq CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BURB Q9NYV4 715 1044 1490.0 RQU:61101 Type1 Inactive DFGin 7.0125 15.984 BLAminus -143.02, -172.66 43.3, 72.03 -94.19, 20.72 281.71, 86.88 -65.05, -33.85 in-in in 8.3112 Saltbr-in 3.3362 HRD-in -64.7, -53.19 72.64, 8.15 in-in-out SNCiio in-out ActLoopNT-in 2.9707 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -98.84, -39.21 APE9-dihe-na -79.75, 149.9 APE8-dihe-in -61.25, 143.48 APE8-rot-out 176.27 APE67-dihe-in -64.0, -30.04 -50.29, -42.66 APE12-dist-in 13.2177 APE11-dist-in 12.7649 APE10-dist-in 7.1593 APE9-dist-in 3.4474 K965R TPO893 TPO893 XRAY 3.64 0.192 0.234 B 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bur CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUSB Q9NYV4 715 1039 1490.0 RMX:1101 Type1 Inactive DFGin 7.0766 15.7189 BLAminus -138.42, 166.28 73.44, 73.47 -93.1, 22.82 287.17, 80.09 -62.57, -33.79 in-in in 8.5069 Saltbr-in 3.3151 HRD-in -69.35, -51.21 75.34, 13.48 in-in-out SNCiio in-out ActLoopNT-in 3.0197 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -86.75, -38.52 APE9-dihe-na -91.11, 154.59 APE8-dihe-in -64.35, 150.44 APE8-rot-out 197.48 APE67-dihe-in -56.11, -29.02 -59.98, -43.72 APE12-dist-in 12.9904 APE11-dist-in 12.5587 APE10-dist-in 6.9784 APE9-dist-in 3.8707 K965R TPO893 TPO893 XRAY 3.26 0.209 0.228 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bus CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUTE Q9NYV4 715 1039 1490.0 RQ5:61101 Type1 Inactive DFGin 7.2983 15.3231 BLAminus -139.51, -178.35 41.51, 85.24 -101.61, 29.69 285.9, 80.14 -70.78, -30.56 in-in in 8.259 Saltbr-in 3.086 HRD-in -67.79, -50.31 72.32, 0.48 in-in-out SNCiio in-out ActLoopNT-in 2.9303 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -100.83, -40.87 APE9-dihe-na -77.17, 152.92 APE8-dihe-in -63.05, 147.04 APE8-rot-out 167.97 APE67-dihe-in -65.55, -27.52 -54.27, -41.89 APE12-dist-in 12.9325 APE11-dist-in 12.5982 APE10-dist-in 6.8078 APE9-dist-in 3.452 K965R TPO893 TPO893 XRAY 3.25 0.198 0.217 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8but CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 6CKXA Q9NYV4 722 1024 1490.0 8M1:1102 Type1 Inactive DFGin 7.032 14.821 BLAminus -136.28, -177.03 50.17, 81.66 -95.72, 28.97 286.79, 82.51 -69.6, -12.29 in-in in 8.9773 Saltbr-in 3.0837 HRD-in -75.68, -51.15 65.95, 11.38 in-in-out SNCiio in-out ActLoopNT-in 3.1223 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -144.15, 162.82 APE9-dihe-na 64.99, 132.37 APE8-dihe-in -65.8, 148.5 APE8-rot-out 58.87 APE67-dihe-in -65.02, -18.1 -33.35, -57.74 APE12-dist-in 13.1407 APE11-dist-in 11.0604 APE10-dist-in 6.8749 APE9-dist-in 3.4947 None TPO893 TPO893 XRAY 2.8 0.21 0.251 A 351.0 293.0 10 29 29 0 [[727, 1020]] 1.0 6ckx CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 6CKXC Q9NYV4 722 1024 1490.0 8M1:1102 Type1 Inactive DFGin 6.9855 14.7579 BLAminus -135.84, -177.96 50.19, 82.31 -95.98, 27.29 286.66, 82.56 -71.33, -10.74 in-in in 8.9818 Saltbr-in 3.064 HRD-in -76.42, -51.05 66.38, 11.81 in-in-out SNCiio in-out ActLoopNT-in 3.093 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -143.35, 161.59 APE9-dihe-na 66.9, 134.68 APE8-dihe-in -66.86, 147.72 APE8-rot-out 60.13 APE67-dihe-in -63.67, -17.47 -33.52, -58.49 APE12-dist-in 13.1506 APE11-dist-in 11.1875 APE10-dist-in 6.9301 APE9-dist-in 3.5241 None TPO893 TPO893 XRAY 2.8 0.21 0.251 C 351.0 293.0 10 29 29 0 [[727, 1020]] 1.0 6ckx CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 7NXKC Q9NYV4 717 1040 1490.0 UUB:2000 Type1 Inactive DFGin 7.2388 15.3617 BLAminus -141.93, -168.1 55.29, 66.48 -89.47, 23.2 285.63, 87.42 -65.95, -22.63 in-none in 9.1644 Saltbr-none 999.0 HRD-in -59.09, -64.11 84.9, -5.29 none-in-out SNCnio in-out ActLoopNT-in 3.0998 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.36, -24.98 APE9-dihe-na -111.23, 152.03 APE8-dihe-in -58.18, 144.58 APE8-rot-out 41.59 APE67-dihe-in -69.39, -10.03 -63.92, -28.51 APE12-dist-in 13.0199 APE11-dist-in 11.29 APE10-dist-in 6.4678 APE9-dist-in 3.4673 None TPO893 TPO893 XRAY 3.0 0.222 0.264 C 351.0 314.0 10 29 29 0 [[727, 1020]] 1.0 7nxk CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUGH Q9NYV4 715 1039 1490.0 No_ligand No_ligand Inactive DFGin 6.8959 15.5984 None -126.85, -81.65 -69.29, 99.31 -95.06, 17.81 283.55, 80.77 -62.15, -37.73 in-out in 8.4976 Saltbr-out 4.2388 HRD-in -64.31, -53.09 70.58, 6.39 out-in-out SNCoio in-out ActLoopNT-in 3.0823 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -77.05, -49.38 APE9-dihe-na -69.37, 152.54 APE8-dihe-in -59.34, 145.1 APE8-rot-out 62.3 APE67-dihe-in -62.01, -33.03 -53.97, -44.11 APE12-dist-in 12.9733 APE11-dist-in 12.4826 APE10-dist-in 6.5883 APE9-dist-in 3.6522 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 H 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bug CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU1B Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 6.8884 15.2984 None -128.47, -62.59 -80.73, 98.22 -97.65, 30.1 286.08, 74.34 -69.36, -27.39 in-in in 7.8207 Saltbr-in 3.2637 HRD-in -79.79, -51.42 72.8, -1.21 in-in-out SNCiio in-out ActLoopNT-in 2.7133 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.4, -55.58 APE9-dihe-na -85.22, 150.62 APE8-dihe-in -62.26, 144.21 APE8-rot-out 179.44 APE67-dihe-in -65.72, -30.15 -51.5, -38.4 APE12-dist-in 13.2818 APE11-dist-in 11.6162 APE10-dist-in 6.9008 APE9-dist-in 3.7142 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 B 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu1 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU1H Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 6.9866 15.4035 None -124.14, -66.45 -82.78, 98.54 -96.09, 28.76 284.79, 71.99 -70.28, -26.46 in-in in 7.8662 Saltbr-in 3.166 HRD-in -79.63, -53.16 73.52, -1.03 in-in-out SNCiio in-out ActLoopNT-in 2.7593 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.57, -50.83 APE9-dihe-na -86.52, 154.66 APE8-dihe-in -59.58, 143.86 APE8-rot-out 8.75 APE67-dihe-in -65.52, -30.46 -51.58, -39.94 APE12-dist-in 13.8095 APE11-dist-in 12.2137 APE10-dist-in 7.2362 APE9-dist-in 3.5954 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu1 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU2B Q9NYV4 715 1041 1490.0 RVQ:61101 Type1 Inactive DFGin 6.9805 15.316 None -126.39, -67.8 -89.47, 99.61 -92.58, 32.18 287.62, 78.29 -74.11, -9.98 in-in in 7.7621 Saltbr-in 3.4941 HRD-in -72.7, -49.44 72.16, 4.81 in-in-in SNCiii in-in ActLoopNT-in 2.9597 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.12, -45.69 APE9-dihe-na -96.32, 148.59 APE8-dihe-in -57.39, 143.59 APE8-rot-in 288.86 APE67-dihe-in -63.0, -36.42 -47.95, -40.21 APE12-dist-in 13.5359 APE11-dist-in 11.7305 APE10-dist-in 7.073 APE9-dist-in 3.726 K965R TPO893 TPO893 XRAY 3.13 0.193 0.217 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bu2 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU3B Q9NYV4 715 1040 1490.0 RSI:1101 Type1 Inactive DFGin 6.8486 15.3593 None -135.97, -63.81 -78.62, 93.23 -91.89, 22.93 285.59, 76.13 -60.89, -23.4 in-in in 7.9934 Saltbr-in 2.817 HRD-in -67.65, -55.64 77.98, -1.58 in-in-in SNCiii in-in ActLoopNT-in 3.0522 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.96, -44.7 APE9-dihe-na -101.31, 148.75 APE8-dihe-in -59.73, 145.03 APE8-rot-in 305.94 APE67-dihe-in -60.6, -36.33 -55.27, -39.92 APE12-dist-in 13.312 APE11-dist-in 11.5417 APE10-dist-in 7.0493 APE9-dist-in 3.3827 K965R TPO893 TPO893 XRAY 3.42 0.187 0.213 B 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8bu3 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU3H Q9NYV4 715 1044 1490.0 RSI:1101 Type1 Inactive DFGin 6.9756 15.4654 None -130.35, -57.76 -91.85, 92.73 -91.21, 19.54 285.51, 78.88 -63.9, -27.23 in-in in 8.132 Saltbr-in 3.2809 HRD-in -66.37, -58.1 77.05, -1.53 in-in-out SNCiio in-out ActLoopNT-in 3.0176 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.62, -44.32 APE9-dihe-na -91.3, 148.63 APE8-dihe-in -63.87, 147.34 APE8-rot-out 172.41 APE67-dihe-in -60.12, -36.58 -54.35, -41.92 APE12-dist-in 13.7142 APE11-dist-in 11.8523 APE10-dist-in 6.8179 APE9-dist-in 3.3613 K965R TPO893 TPO893 XRAY 3.42 0.187 0.213 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu3 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU5E Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 6.9424 15.1221 None -123.64, -63.66 -81.97, -51.09 56.28, 22.54 292.49, 98.9 -91.33, -28.22 in-out in 8.3713 Saltbr-out 3.6222 HRD-in -72.77, -54.57 74.45, -4.91 out-in-out SNCoio in-out ActLoopNT-in 2.7589 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -134.16, -27.33 APE9-dihe-na -98.05, 157.33 APE8-dihe-in -51.55, 136.25 APE8-rot-in 308.17 APE67-dihe-in -63.16, -26.85 -49.17, -41.17 APE12-dist-out 14.1246 APE11-dist-in 12.1682 APE10-dist-in 7.2856 APE9-dist-in 3.7263 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 E 344.0 331.0 0 29 29 0 [[727, 1020]] 1.0 8bu5 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU6B Q9NYV4 715 1039 1490.0 RQE:61101 Type1 Inactive DFGin 6.9772 15.0095 None -127.82, -64.26 -87.77, 91.87 -89.24, 20.45 288.89, 72.08 -65.57, -40.39 in-in in 8.424 Saltbr-in 3.4813 HRD-in -70.61, -57.84 77.83, -2.42 in-in-out SNCiio in-out ActLoopNT-in 3.1224 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.14, -54.56 APE9-dihe-na -81.61, 149.37 APE8-dihe-in -53.79, 145.32 APE8-rot-out 74.18 APE67-dihe-in -56.42, -37.71 -55.03, -39.62 APE12-dist-in 13.9274 APE11-dist-in 11.7836 APE10-dist-in 6.969 APE9-dist-in 3.408 K965R TPO893 TPO893 XRAY 3.45 0.219 0.249 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu6 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU6H Q9NYV4 715 1038 1490.0 RQE:61101 Type1 Inactive DFGin 6.8592 15.2278 None -123.73, -80.29 -80.87, 99.66 -87.02, 20.65 285.61, 58.62 -65.39, -44.16 in-out in 8.4216 Saltbr-out 5.0958 HRD-in -73.68, -57.19 78.4, -0.7 out-in-out SNCoio in-out ActLoopNT-in 3.0861 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.54, -53.3 APE9-dihe-na -74.55, 153.16 APE8-dihe-in -53.11, 139.67 APE8-rot-out 166.86 APE67-dihe-in -53.97, -35.01 -57.57, -41.34 APE12-dist-in 13.1365 APE11-dist-in 12.4283 APE10-dist-in 7.0199 APE9-dist-in 3.4215 K965R TPO893 TPO893 XRAY 3.45 0.219 0.249 H 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bu6 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BU9B Q9NYV4 715 1039 1490.0 RRC:61101 Type1 Inactive DFGin 6.8954 15.5504 None -126.5, -98.68 -52.95, 118.93 -112.03, 20.69 280.85, 78.53 -65.13, -14.55 in-in in 8.0334 Saltbr-in 3.4619 HRD-in -71.08, -52.06 74.5, 2.49 in-in-out SNCiio in-out ActLoopNT-in 3.0383 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.03, -51.01 APE9-dihe-na -76.4, 148.49 APE8-dihe-in -61.77, 145.89 APE8-rot-out 190.86 APE67-dihe-in -62.1, -33.32 -50.51, -38.53 APE12-dist-in 13.2624 APE11-dist-in 11.7849 APE10-dist-in 6.4997 APE9-dist-in 3.5775 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUBH Q9NYV4 715 1044 1490.0 RNU:61102 Type1 Inactive DFGin 7.2638 15.677 None -126.03, -25.89 -87.61, 72.88 -91.51, 12.82 280.63, 73.67 -60.75, -39.82 in-in in 8.4819 Saltbr-in 3.5525 HRD-out -79.78, 93.25 -67.97, -38.17 in-out-out SNCioo out-out ActLoopNT-out 3.72 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iiii APE10-dihe-na -109.56, -9.94 APE9-dihe-na -106.55, 22.31 APE8-dihe-out 64.82, 23.4 APE8-rot-out 71.99 APE67-dihe-out -104.68, -30.69 71.46, -1.72 APE12-dist-in 12.7113 APE11-dist-in 12.093 APE10-dist-in 6.8605 APE9-dist-in 4.5978 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bub CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUCH Q9NYV4 715 1044 1490.0 RKO:61101 Type1 Inactive DFGin 6.938 15.2425 None -126.85, -64.01 -88.43, 98.06 -96.23, 24.88 287.21, 69.27 -75.34, -9.66 in-in in 7.9464 Saltbr-in 3.3005 HRD-in -84.47, -51.91 75.61, -7.74 in-in-in SNCiii in-in ActLoopNT-in 2.9789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.44, -52.72 APE9-dihe-na -81.82, 150.47 APE8-dihe-in -58.85, 136.79 APE8-rot-in 300.83 APE67-dihe-in -60.33, -38.14 -49.32, -40.23 APE12-dist-in 13.7625 APE11-dist-in 11.7819 APE10-dist-in 6.9727 APE9-dist-in 3.2597 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8buc CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUEB Q9NYV4 715 1043 1490.0 RVU:61101 Type1 Inactive DFGin 6.8762 15.6 None -134.01, -59.19 -81.95, 94.22 -92.57, 38.59 286.02, 76.0 -80.72, -24.77 in-in in 7.932 Saltbr-in 2.9874 HRD-in -72.56, -56.91 77.87, 2.52 in-in-out SNCiio in-out ActLoopNT-in 2.9042 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.91, -27.24 APE9-dihe-na -111.61, 155.18 APE8-dihe-in -59.11, 144.49 APE8-rot-out 174.63 APE67-dihe-in -64.14, -33.78 -56.66, -36.69 APE12-dist-in 13.2286 APE11-dist-in 11.5753 APE10-dist-in 6.8399 APE9-dist-in 3.7328 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 B 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bue CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUFB Q9NYV4 715 1033 1490.0 RW6:61101 Type1 Inactive DFGin 6.9051 15.6357 None -129.93, -62.21 -79.23, 97.53 -95.7, 37.47 286.05, 76.01 -76.9, -21.74 in-in in 8.1053 Saltbr-in 3.1532 HRD-in -72.11, -52.31 75.51, 2.58 in-in-out SNCiio in-out ActLoopNT-in 2.8864 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.68, -63.24 APE9-dihe-na -77.98, 146.57 APE8-dihe-in -61.93, 149.44 APE8-rot-out 186.78 APE67-dihe-in -61.63, -31.53 -53.67, -39.8 APE12-dist-in 13.1702 APE11-dist-in 10.9939 APE10-dist-in 6.5903 APE9-dist-in 3.5503 K965R TPO893 TPO893 XRAY 3.3 0.185 0.22 B 344.0 319.0 0 29 29 0 [[727, 1020]] 1.0 8buf CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUFH Q9NYV4 715 1032 1490.0 RW6:61101 Type1 Inactive DFGin 7.1171 15.5053 None -129.62, -58.72 -84.56, 91.07 -93.16, 33.34 286.36, 76.3 -77.96, -20.03 in-out in 8.1468 Saltbr-out 3.7328 HRD-in -74.59, -54.27 72.47, 1.47 out-in-in SNCoii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.36, -62.78 APE9-dihe-na -81.18, 153.72 APE8-dihe-in -60.4, 148.16 APE8-rot-in 306.45 APE67-dihe-in -63.34, -32.17 -56.22, -41.31 APE12-dist-in 13.7169 APE11-dist-in 11.792 APE10-dist-in 7.061 APE9-dist-in 3.3785 K965R TPO893 TPO893 XRAY 3.3 0.185 0.22 H 344.0 318.0 0 29 29 0 [[727, 1020]] 1.0 8buf CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUGB Q9NYV4 715 1041 1490.0 RPW:61101 Type1 Inactive DFGin 6.885 15.532 None -132.35, -51.84 -89.28, 88.82 -91.59, 19.28 282.49, 80.64 -62.07, -38.03 in-in in 8.0337 Saltbr-in 2.912 HRD-in -62.84, -54.31 70.37, 7.41 in-in-out SNCiio in-out ActLoopNT-in 3.0011 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -68.25, -47.63 APE9-dihe-na -75.15, 151.02 APE8-dihe-in -63.11, 148.71 APE8-rot-out 182.54 APE67-dihe-in -62.59, -33.17 -53.62, -43.42 APE12-dist-in 12.5031 APE11-dist-in 11.8127 APE10-dist-in 6.379 APE9-dist-in 3.619 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bug CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUHB Q9NYV4 715 1039 1490.0 RR9:61101 Type1 Inactive DFGin 7.1787 15.539 None -138.13, -51.2 -84.38, 89.05 -94.33, 22.38 291.72, 70.83 -65.07, -27.18 in-in in 8.1562 Saltbr-in 3.1703 HRD-in -65.3, -52.38 69.31, 6.78 in-in-out SNCiio in-out ActLoopNT-in 2.9184 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -73.08, -42.42 APE9-dihe-na -75.03, 155.7 APE8-dihe-in -68.77, 151.86 APE8-rot-out 184.25 APE67-dihe-in -61.51, -37.69 -56.24, -40.88 APE12-dist-in 12.2995 APE11-dist-in 11.9854 APE10-dist-in 6.1967 APE9-dist-in 3.6729 K965R TPO893 TPO893 XRAY 3.79 0.189 0.232 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8buh CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUHH Q9NYV4 715 1033 1490.0 RR9:61101 Type1 Inactive DFGin 6.8874 15.2204 None -138.17, -50.63 -86.02, 83.59 -88.15, 19.63 292.55, 71.89 -63.06, -22.61 in-in in 8.184 Saltbr-in 2.9431 HRD-in -66.24, -47.16 69.47, -1.27 in-in-out SNCiio in-out ActLoopNT-in 3.0446 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -73.8, -40.23 APE9-dihe-na -75.94, 158.01 APE8-dihe-in -67.45, 146.95 APE8-rot-out 179.42 APE67-dihe-in -59.63, -39.48 -58.91, -41.72 APE12-dist-in 13.2298 APE11-dist-in 12.4677 APE10-dist-in 6.767 APE9-dist-in 3.3762 K965R TPO893 TPO893 XRAY 3.79 0.189 0.232 H 344.0 319.0 0 29 29 0 [[727, 1020]] 1.0 8buh CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUJB Q9NYV4 715 1041 1490.0 RUW:1101 Type1 Inactive DFGin 6.983 15.1999 None -129.99, -57.9 -94.94, 86.34 -84.73, 29.33 287.08, 75.1 -66.06, -25.85 in-in in 7.8642 Saltbr-in 2.9459 HRD-in -63.86, -54.33 75.41, -2.11 in-in-out SNCiio in-out ActLoopNT-in 3.0628 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -117.09, -50.74 APE9-dihe-na -90.83, 154.53 APE8-dihe-in -64.5, 148.14 APE8-rot-out 189.98 APE67-dihe-in -60.8, -34.01 -57.18, -38.53 APE12-dist-in 13.2622 APE11-dist-in 11.4247 APE10-dist-in 7.1058 APE9-dist-in 3.5216 K965R TPO893 TPO893 XRAY 3.62 0.164 0.206 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8buj CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUJH Q9NYV4 715 1043 1490.0 RUW:1101 Type1 Inactive DFGin 6.896 15.0772 None -125.46, -61.45 -96.84, 87.36 -85.01, 26.05 287.54, 74.01 -66.36, -25.41 in-in in 7.8133 Saltbr-in 3.0099 HRD-in -63.78, -55.47 74.76, -1.95 in-in-in SNCiii in-in ActLoopNT-in 2.9668 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.8, -48.82 APE9-dihe-na -90.4, 155.44 APE8-dihe-in -63.14, 147.75 APE8-rot-in 306.89 APE67-dihe-in -59.19, -33.71 -59.17, -40.93 APE12-dist-in 13.546 APE11-dist-in 11.4373 APE10-dist-in 6.9005 APE9-dist-in 3.4536 K965R TPO893 TPO893 XRAY 3.62 0.164 0.206 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8buj CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUKB Q9NYV4 715 1040 1490.0 RWE:61101 Type1 Inactive DFGin 6.8676 15.185 None -136.79, -63.9 -86.16, 95.92 -96.18, 34.75 292.05, 70.82 -73.05, -21.93 in-in in 7.9967 Saltbr-in 2.8964 HRD-in -70.18, -56.12 75.44, 6.36 in-in-in SNCiii in-in ActLoopNT-in 2.9507 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.1, -51.8 APE9-dihe-na -97.16, 156.72 APE8-dihe-in -60.0, 144.72 APE8-rot-in 296.0 APE67-dihe-in -62.91, -30.64 -55.4, -37.75 APE12-dist-in 13.3442 APE11-dist-in 11.4945 APE10-dist-in 7.2213 APE9-dist-in 3.6338 K965R TPO893 TPO893 XRAY 3.41 0.186 0.21 B 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8buk CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUKH Q9NYV4 715 1044 1490.0 RWE:61101 Type1 Inactive DFGin 6.839 15.2471 None -132.41, -70.3 -85.48, 98.43 -94.85, 32.62 289.18, 70.32 -75.66, -23.83 in-in in 8.0838 Saltbr-in 3.0875 HRD-in -67.86, -57.14 74.14, 6.98 in-in-out SNCiio in-out ActLoopNT-in 2.8859 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -102.71, -45.22 APE9-dihe-na -97.3, 156.39 APE8-dihe-in -62.45, 146.81 APE8-rot-out 169.98 APE67-dihe-in -63.55, -31.48 -56.16, -39.65 APE12-dist-in 13.6893 APE11-dist-in 11.7966 APE10-dist-in 7.1304 APE9-dist-in 3.7281 K965R TPO893 TPO893 XRAY 3.41 0.186 0.21 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8buk CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BULB Q9NYV4 715 1039 1490.0 RSU:1101 Type1 Inactive DFGin 7.0478 15.5723 None -134.15, -61.62 -82.15, 93.36 -91.03, 19.31 284.15, 82.25 -57.36, -30.14 in-in in 7.9382 Saltbr-in 2.9293 HRD-in -70.64, -53.34 75.97, 4.36 in-in-in SNCiii in-in ActLoopNT-in 3.1167 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.1, -23.33 APE9-dihe-na -106.91, 152.49 APE8-dihe-in -59.59, 141.04 APE8-rot-in 301.22 APE67-dihe-in -61.09, -37.16 -52.97, -42.84 APE12-dist-in 13.2976 APE11-dist-in 11.6069 APE10-dist-in 6.723 APE9-dist-in 3.6083 None TPO893 TPO893 XRAY 3.4 0.179 0.215 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bul CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUMB Q9NYV4 715 1040 1490.0 T6X:1101 Type1 Inactive DFGin 6.8637 15.6654 None -134.73, -83.5 -67.29, 93.27 -90.11, 26.53 284.48, 75.06 -65.26, -28.59 in-in in 7.994 Saltbr-in 3.4847 HRD-in -65.89, -56.24 77.66, 6.87 in-in-in SNCiii in-in ActLoopNT-in 3.1268 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.13, -38.62 APE9-dihe-na -95.11, 154.79 APE8-dihe-in -60.97, 148.11 APE8-rot-in 309.8 APE67-dihe-in -61.69, -36.7 -58.55, -38.83 APE12-dist-in 13.4563 APE11-dist-in 11.5984 APE10-dist-in 6.6698 APE9-dist-in 3.6672 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 B 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8bum CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUMH Q9NYV4 715 1039 1490.0 T6X:1101 Type1 Inactive DFGin 7.0235 15.4568 None -135.37, -57.05 -84.79, 89.46 -91.01, 22.09 287.95, 72.46 -66.77, -30.21 in-out in 8.0681 Saltbr-out 4.1308 HRD-in -66.21, -56.87 75.95, 5.67 out-in-in SNCoii in-in ActLoopNT-in 2.9548 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.45, -40.59 APE9-dihe-na -95.46, 155.5 APE8-dihe-in -61.11, 150.0 APE8-rot-in 312.75 APE67-dihe-in -61.06, -36.71 -56.48, -41.62 APE12-dist-in 13.6249 APE11-dist-in 11.7363 APE10-dist-in 7.1678 APE9-dist-in 3.5793 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 H 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bum CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUOH Q9NYV4 715 1044 1490.0 RLC:1101 Type1 Inactive DFGin 6.9531 15.2665 None -133.0, -52.84 -89.06, 92.6 -92.03, 19.54 286.01, 76.31 -65.14, -29.67 in-in in 8.1958 Saltbr-in 3.2893 HRD-in -68.8, -55.72 77.31, -13.16 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.5, -30.39 APE9-dihe-na -96.1, 151.94 APE8-dihe-in -61.51, 140.45 APE8-rot-in 333.9 APE67-dihe-in -58.03, -34.02 -53.9, -41.38 APE12-dist-in 13.5492 APE11-dist-in 11.7907 APE10-dist-in 6.7655 APE9-dist-in 3.3578 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8buo CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUQH Q9NYV4 715 1035 1490.0 RQ9:61101 Type1 Inactive DFGin 6.8471 15.4131 None -139.0, -68.9 -74.65, 86.14 -87.77, 25.62 285.6, 75.05 -68.98, -27.88 in-in in 8.1409 Saltbr-in 3.3418 HRD-in -71.56, -55.82 75.32, -0.25 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.77, -46.85 APE9-dihe-na -88.37, 155.15 APE8-dihe-in -63.62, 147.91 APE8-rot-out 74.55 APE67-dihe-in -59.91, -28.34 -56.29, -43.5 APE12-dist-in 13.7059 APE11-dist-in 11.9801 APE10-dist-in 7.0593 APE9-dist-in 3.5434 K965R TPO893 TPO893 XRAY 3.2 0.196 0.216 H 344.0 321.0 0 29 29 0 [[727, 1020]] 1.0 8buq CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BURH Q9NYV4 715 1039 1490.0 RQU:61101 Type1 Inactive DFGin 6.7739 15.4438 None -128.98, -68.65 -83.3, 94.14 -94.27, 19.71 289.32, 85.87 -66.64, -31.92 in-in in 8.1448 Saltbr-in 2.8791 HRD-in -62.95, -51.76 69.51, 6.54 in-in-out SNCiio in-out ActLoopNT-in 3.108 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -119.35, -54.64 APE9-dihe-na -87.35, 151.65 APE8-dihe-in -60.57, 144.24 APE8-rot-out 76.95 APE67-dihe-in -62.32, -33.37 -50.2, -40.95 APE12-dist-in 13.7432 APE11-dist-in 11.6616 APE10-dist-in 7.0858 APE9-dist-in 3.6711 K965R TPO893 TPO893 XRAY 3.64 0.192 0.234 H 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bur CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 8BUSE Q9NYV4 715 1043 1490.0 RMX:1101 Type1 Inactive DFGin 6.7257 15.8693 None -132.84, -50.43 -84.41, 82.25 -87.45, 22.35 281.7, 77.83 -63.73, -33.79 in-in in 8.1583 Saltbr-in 3.2823 HRD-in -70.71, -48.94 71.36, 12.53 in-in-out SNCiio in-out ActLoopNT-in 2.9956 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -96.11, -47.21 APE9-dihe-na -97.32, 150.19 APE8-dihe-in -67.32, 151.1 APE8-rot-out 195.8 APE67-dihe-in -58.67, -27.66 -56.54, -42.34 APE12-dist-in 13.2846 APE11-dist-in 11.3926 APE10-dist-in 7.3398 APE9-dist-in 3.4564 K965R TPO893 TPO893 XRAY 3.26 0.209 0.228 E 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bus CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 9FMRB Q9NYV4 714 1047 1490.0 RMF:61101 Type1 Inactive DFGin 7.1242 15.0312 None -111.49, -74.26 -77.99, -72.15 68.85, 12.84 296.16, 89.8 -66.22, -36.51 in-out in 8.3316 Saltbr-out 4.4499 HRD-in -70.8, -35.56 62.81, 1.22 out-in-in SNCoii in-in ActLoopNT-in 3.0722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.03, -25.75 APE9-dihe-na -103.56, 146.88 APE8-dihe-in -51.72, 138.27 APE8-rot-in 305.58 APE67-dihe-in -69.51, -21.36 -53.61, -35.19 APE12-dist-in 13.9874 APE11-dist-in 12.2701 APE10-dist-in 7.331 APE9-dist-in 3.8645 None TPO893 TPO893 XRAY 3.9 0.209 0.25 B 351.0 334.0 0 29 29 0 [[727, 1020]] 1.0 9fmr CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

CMGC_CDK12 (Cyclin-dependent kinase 12)

Total number of chains: 109
Active chains: 10
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 53 48.6% AF-Q9NYV4-K1A
DFGin None 30 27.5% 8BU1B
DFGin ABAminus 26 23.9% 8BUNB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK12 CDK12_HUMAN AF-Q9NYV4-K1A Q9NYV4 719 1028 1490.0 No_ligand No_ligand Active DFGin 6.7425 15.0213 BLAminus -135.31, 176.11 57.83, 65.7 -78.9, 19.02 283.91, 75.49 -59.53, -34.42 in-in in 8.8479 Saltbr-in 2.8717 HRD-in -74.38, -50.97 65.06, 11.96 in-in-in SNCiii in-in ActLoopNT-in 2.9537 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.35, 171.85 APE9-dihe-na 62.69, 132.06 APE8-dihe-in -56.47, 137.03 APE8-rot-in 300.21 APE67-dihe-in -68.24, -22.81 -49.07, -40.83 APE12-dist-in 13.0672 APE11-dist-in 11.1954 APE10-dist-in 6.6339 APE9-dist-in 3.3445 None None None AF2 -1.0 1.0 1.0 A 310.0 310.0 0 29 29 0 [[727, 1020]] 1.0 AF-Q9NYV4-K1 Homo sapiens CMGC_CDK12_HUMAN CMGC 1.8e-84 289.4 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN AF-Q9NYV4-K3A Q9NYV4 719 1028 1490.0 No_ligand No_ligand Active DFGin 6.9432 15.648 BLAminus -131.2, -179.25 62.41, 52.03 -71.34, 9.91 284.98, 77.79 -61.92, -24.64 in-in in 8.4488 Saltbr-in 3.0263 HRD-in -78.33, -50.25 65.94, 8.6 in-in-in SNCiii in-in ActLoopNT-in 2.9006 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.81, 169.8 APE9-dihe-na 61.73, 134.8 APE8-dihe-in -58.63, 136.64 APE8-rot-in 295.26 APE67-dihe-in -64.98, -27.17 -49.82, -42.02 APE12-dist-in 13.4806 APE11-dist-in 11.6092 APE10-dist-in 7.1738 APE9-dist-in 3.2099 None None None AF2 -1.0 1.0 1.0 A 310.0 310.0 0 29 29 0 [[727, 1020]] 1.0 AF-Q9NYV4-K3 Homo sapiens CMGC_CDK12_HUMAN CMGC 1.8e-84 289.4 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU7B Q9NYV4 715 1043 1490.0 No_ligand No_ligand Active DFGin 7.0774 15.5436 BLAminus -153.2, -179.33 57.0, 56.86 -76.66, 35.76 288.9, 72.8 -62.53, -36.58 in-in in 7.9444 Saltbr-in 2.9696 HRD-in -65.11, -49.8 70.58, 2.94 in-in-in SNCiii in-in ActLoopNT-in 2.9018 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.3, -42.09 APE9-dihe-na -92.76, 146.08 APE8-dihe-in -61.7, 141.25 APE8-rot-in 286.85 APE67-dihe-in -64.16, -31.94 -48.15, -39.73 APE12-dist-in 12.7959 APE11-dist-in 11.3036 APE10-dist-in 6.4396 APE9-dist-in 3.7225 K965R TPO893 TPO893 XRAY 3.245 0.193 0.219 B 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bu7 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU7H Q9NYV4 715 1043 1490.0 No_ligand No_ligand Active DFGin 6.9253 15.2163 BLAminus -150.49, -178.12 60.69, 55.85 -80.72, 28.91 286.49, 71.19 -68.37, -37.18 in-in in 7.9973 Saltbr-in 3.1269 HRD-in -67.99, -49.39 67.61, 1.86 in-in-in SNCiii in-in ActLoopNT-in 2.9304 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.1, -50.99 APE9-dihe-na -89.61, 147.06 APE8-dihe-in -59.45, 144.95 APE8-rot-in 311.35 APE67-dihe-in -64.87, -31.1 -48.4, -40.63 APE12-dist-in 13.8207 APE11-dist-in 11.6376 APE10-dist-in 7.151 APE9-dist-in 3.5678 K965R TPO893 TPO893 XRAY 3.245 0.193 0.219 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bu7 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 6TD3E Q9NYV4 715 1047 1490.0 RC8:1101 Type1 Active DFGin 7.044 15.1934 BLAminus -147.32, 173.39 63.76, 65.42 -84.24, 25.56 288.49, 76.82 -64.44, -36.48 in-in in 7.9743 Saltbr-in 3.1673 HRD-in -75.19, -47.55 67.28, 2.07 in-in-in SNCiii in-in ActLoopNT-in 2.9532 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -75.91, -39.12 APE9-dihe-na -86.17, 150.74 APE8-dihe-in -63.73, 141.42 APE8-rot-in 305.37 APE67-dihe-in -59.47, -32.88 -40.08, -54.92 APE12-dist-in 13.1756 APE11-dist-in 11.9025 APE10-dist-in 6.8549 APE9-dist-in 3.4348 K965R TPO893 TPO893 XRAY 3.46 0.195 0.22 E 344.0 333.0 0 29 29 0 [[727, 1020]] 1.0 6td3 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU3E Q9NYV4 715 1039 1490.0 RSI:1101 Type1 Active DFGin 7.1413 15.5345 BLAminus -142.27, 178.66 43.04, 82.11 -92.94, 21.36 280.44, 78.98 -62.21, -28.8 in-in in 8.1181 Saltbr-in 3.0489 HRD-in -67.4, -56.47 76.99, -0.73 in-in-in SNCiii in-in ActLoopNT-in 2.9745 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.29, 7.21 APE9-dihe-na -139.88, 150.07 APE8-dihe-in -59.05, 143.88 APE8-rot-in 303.03 APE67-dihe-in -61.38, -34.53 -56.72, -42.72 APE12-dist-in 13.1066 APE11-dist-in 12.7602 APE10-dist-in 7.1748 APE9-dist-in 3.4462 K965R TPO893 TPO893 XRAY 3.42 0.187 0.213 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu3 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BULE Q9NYV4 715 1038 1490.0 RSU:1101 Type1 Active DFGin 7.2685 15.5744 BLAminus -142.23, 173.11 51.26, 74.93 -90.42, 13.84 281.63, 81.18 -57.04, -28.57 in-in in 8.0731 Saltbr-in 3.0676 HRD-in -70.66, -53.79 75.17, 4.92 in-in-in SNCiii in-in ActLoopNT-in 2.9194 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.18, -18.48 APE9-dihe-na -95.24, 149.84 APE8-dihe-in -59.92, 143.14 APE8-rot-in 301.12 APE67-dihe-in -61.61, -35.96 -53.3, -43.95 APE12-dist-in 12.7273 APE11-dist-in 12.5302 APE10-dist-in 6.6866 APE9-dist-in 3.3853 None TPO893 TPO893 XRAY 3.4 0.179 0.215 E 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bul Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUME Q9NYV4 715 1039 1490.0 T6X:1101 Type1 Active DFGin 7.1739 15.4836 BLAminus -146.26, -169.41 35.67, 76.14 -91.08, 23.16 287.18, 101.24 -64.43, -27.28 in-in in 8.3789 Saltbr-in 3.3933 HRD-in -65.58, -57.98 78.09, 6.9 in-in-in SNCiii in-in ActLoopNT-in 3.007 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.86, -32.86 APE9-dihe-na -90.18, 155.36 APE8-dihe-in -60.4, 149.13 APE8-rot-in 310.02 APE67-dihe-in -62.09, -34.98 -57.41, -41.5 APE12-dist-in 12.684 APE11-dist-in 12.1018 APE10-dist-in 6.7473 APE9-dist-in 3.3803 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bum Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUPH Q9NYV4 715 1028 1490.0 RWN:61101 Type1 Active DFGin 7.1094 15.4064 BLAminus -147.42, -178.11 55.21, 58.82 -78.24, 30.65 278.56, 80.87 -74.41, -18.78 in-in in 8.0924 Saltbr-in 3.3148 HRD-in -72.38, -49.1 69.31, -11.39 in-in-in SNCiii in-in ActLoopNT-in 3.0338 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.08, -16.8 APE9-dihe-na -129.39, 159.74 APE8-dihe-in -65.11, 144.15 APE8-rot-in 304.17 APE67-dihe-in -60.23, -34.65 -53.66, -41.25 APE12-dist-in 13.3065 APE11-dist-in 10.9767 APE10-dist-in 7.0684 APE9-dist-in 3.5015 K965R TPO893 TPO893 XRAY 3.41 0.201 0.223 H 344.0 314.0 0 29 29 0 [[727, 1020]] 1.0 8bup Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8P81A Q9NYV4 716 1035 1490.0 RMF:1101 Type1 Active DFGin 7.0954 14.4463 BLAminus -134.83, -178.64 59.2, 72.19 -89.53, 34.88 291.56, 80.44 -67.97, -22.73 in-in in 8.3586 Saltbr-in 3.0568 HRD-in -81.5, -42.97 59.01, 18.94 in-in-in SNCiii in-in ActLoopNT-in 2.9629 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.63, 165.61 APE9-dihe-na 67.08, 139.25 APE8-dihe-in -61.99, 152.33 APE8-rot-in 316.49 APE67-dihe-in -68.12, -20.85 -57.98, -41.98 APE12-dist-in 12.6789 APE11-dist-in 10.561 APE10-dist-in 6.5202 APE9-dist-in 3.2122 None TPO893 TPO893 XRAY 2.68 0.212 0.255 A 351.0 320.0 0 29 29 0 [[727, 1020]] 1.0 8p81 Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU2H Q9NYV4 715 1043 1490.0 RVQ:61101 Type1 Inactive DFGin 7.1243 15.3663 ABAminus -126.78, -38.9 -105.5, 92.35 -91.27, 30.22 285.75, 68.07 -78.32, -11.53 in-in in 7.7854 Saltbr-in 3.3155 HRD-in -76.93, -54.56 71.73, 6.27 in-in-in SNCiii in-in ActLoopNT-in 2.7922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.54, -42.84 APE9-dihe-na -100.7, 153.79 APE8-dihe-in -58.19, 144.22 APE8-rot-in 306.05 APE67-dihe-in -62.43, -37.08 -51.71, -42.2 APE12-dist-in 13.8509 APE11-dist-in 11.9364 APE10-dist-in 7.2084 APE9-dist-in 3.6382 K965R TPO893 TPO893 XRAY 3.13 0.193 0.217 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bu2 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU4B Q9NYV4 715 1043 1490.0 RQL:61101 Type1 Inactive DFGin 6.85 15.4476 ABAminus -129.55, -62.28 -85.09, 103.01 -99.2, 24.51 288.36, 76.72 -66.96, -36.21 in-in in 8.3567 Saltbr-in 2.9754 HRD-in -68.4, -61.77 77.35, 4.99 in-in-out SNCiio in-out ActLoopNT-in 2.9924 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.64, -39.36 APE9-dihe-na -92.3, 149.92 APE8-dihe-in -61.52, 149.36 APE8-rot-out 186.04 APE67-dihe-in -64.54, -31.54 -56.18, -38.32 APE12-dist-in 13.385 APE11-dist-in 11.5066 APE10-dist-in 6.6111 APE9-dist-in 3.4581 K965R TPO893 TPO893 XRAY 3.09 0.205 0.223 B 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bu4 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU4H Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 7.0469 15.5284 ABAminus -118.75, -57.9 -97.23, 97.83 -98.97, 29.55 288.47, 78.73 -75.71, -15.5 in-out in 8.2875 Saltbr-out 3.9063 HRD-in -79.59, -55.06 74.66, 4.8 out-in-out SNCoio in-out ActLoopNT-in 2.8791 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -121.0, -34.01 APE9-dihe-na -98.0, 156.31 APE8-dihe-in -61.54, 149.21 APE8-rot-out 67.45 APE67-dihe-in -64.95, -40.0 -58.15, -33.89 APE12-dist-in 13.8217 APE11-dist-in 12.0458 APE10-dist-in 7.1648 APE9-dist-in 3.5506 K965R TPO893 TPO893 XRAY 3.09 0.205 0.223 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu4 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU5B Q9NYV4 713 1044 1490.0 RMF:1101 Type1 Inactive DFGin 6.8015 14.7007 ABAminus -126.95, -66.04 -93.95, 105.24 -102.41, 30.18 293.69, 100.66 -84.84, -22.58 in-out in 8.3047 Saltbr-out 3.9335 HRD-out -78.59, 106.12 -94.17, 5.74 out-in-out SNCoio in-out ActLoopNT-in 2.8278 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -136.91, -22.25 APE9-dihe-na -109.89, 157.52 APE8-dihe-in -56.01, 131.78 APE8-rot-in 308.02 APE67-dihe-in -60.99, -26.61 -52.03, -40.26 APE12-dist-out 14.2801 APE11-dist-in 11.9408 APE10-dist-in 7.3604 APE9-dist-in 3.7666 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 B 344.0 332.0 0 29 29 0 [[727, 1020]] 1.0 8bu5 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU5H Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 7.0152 14.9781 ABAminus -128.46, -54.53 -90.71, 103.12 -97.22, 31.8 290.43, 81.59 -85.33, -25.69 in-in in 8.4795 Saltbr-in 3.5275 HRD-in -73.55, -49.58 63.85, -4.76 in-in-in SNCiii in-in ActLoopNT-in 2.6292 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.5, -28.02 APE9-dihe-na -97.36, 153.71 APE8-dihe-in -57.72, 135.61 APE8-rot-in 311.07 APE67-dihe-in -63.38, -27.52 -50.57, -39.59 APE12-dist-in 13.9415 APE11-dist-in 12.128 APE10-dist-in 7.2577 APE9-dist-in 3.4973 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 H 344.0 331.0 0 29 29 0 [[727, 1020]] 1.0 8bu5 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU9H Q9NYV4 715 1038 1490.0 RRC:61101 Type1 Inactive DFGin 6.8966 15.0279 ABAminus -130.72, -61.46 -86.64, 101.77 -100.72, 17.49 288.44, 80.02 -65.69, -13.23 in-in in 8.1483 Saltbr-in 3.5944 HRD-in -73.34, -52.41 71.89, 3.55 in-in-out SNCiio in-out ActLoopNT-in 2.7833 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.4, -56.59 APE9-dihe-na -80.8, 152.68 APE8-dihe-in -61.03, 143.88 APE8-rot-out 47.91 APE67-dihe-in -59.68, -32.23 -55.45, -41.09 APE12-dist-in 13.7228 APE11-dist-in 11.9439 APE10-dist-in 7.0071 APE9-dist-in 3.5232 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 H 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUAB Q9NYV4 715 1039 1490.0 RVH:1101 Type1 Inactive DFGin 6.6602 15.3703 ABAminus -132.25, -47.59 -83.62, 100.61 -101.79, 23.05 288.11, 77.38 -59.48, -33.33 in-in in 8.0717 Saltbr-in 2.9334 HRD-in -66.14, -55.51 74.2, 0.02 in-in-in SNCiii in-in ActLoopNT-in 2.9584 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.76, -47.66 APE9-dihe-na -82.97, 151.34 APE8-dihe-in -63.64, 142.13 APE8-rot-in 293.22 APE67-dihe-in -60.49, -35.73 -49.76, -42.55 APE12-dist-in 13.5676 APE11-dist-in 11.7656 APE10-dist-in 6.6656 APE9-dist-in 3.5427 K965R TPO893 TPO893 XRAY 3.193 0.202 0.225 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bua Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUAE Q9NYV4 715 1033 1490.0 RVH:1101 Type1 Inactive DFGin 6.9569 15.0827 ABAminus -126.35, -57.7 -89.06, 99.95 -100.88, 19.34 288.21, 78.03 -60.59, -33.21 in-out in 8.3642 Saltbr-out 3.6783 HRD-in -67.84, -57.25 75.2, 0.85 out-in-out SNCoio in-out ActLoopNT-in 2.9234 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -70.04, -46.21 APE9-dihe-na -79.96, 152.67 APE8-dihe-in -66.28, 142.61 APE8-rot-out 169.95 APE67-dihe-in -61.55, -33.2 -51.95, -45.85 APE12-dist-in 13.685 APE11-dist-in 12.0864 APE10-dist-in 6.7662 APE9-dist-in 3.4225 K965R TPO893 TPO893 XRAY 3.193 0.202 0.225 E 344.0 319.0 0 29 29 0 [[727, 1020]] 1.0 8bua Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUAH Q9NYV4 715 1034 1490.0 RVH:1101 Type1 Inactive DFGin 6.8833 15.4199 ABAminus -126.04, -56.2 -88.9, 101.16 -97.82, 20.48 283.52, 73.51 -61.26, -31.16 in-in in 7.9328 Saltbr-in 2.9687 HRD-in -68.56, -58.56 73.11, 1.68 in-in-out SNCiio in-out ActLoopNT-in 2.8965 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -115.42, -52.09 APE9-dihe-na -83.64, 155.3 APE8-dihe-in -61.52, 141.11 APE8-rot-in 293.24 APE67-dihe-in -60.38, -38.31 -51.83, -39.97 APE12-dist-out 14.0879 APE11-dist-in 12.2501 APE10-dist-in 7.2726 APE9-dist-in 3.5461 K965R TPO893 TPO893 XRAY 3.193 0.202 0.225 H 344.0 320.0 0 29 29 0 [[727, 1020]] 1.0 8bua Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUCB Q9NYV4 715 1041 1490.0 RKO:61101 Type1 Inactive DFGin 6.8353 15.4949 ABAminus -130.47, -49.88 -100.7, 87.88 -87.1, 28.61 287.17, 76.07 -67.87, -32.97 in-in in 8.1269 Saltbr-in 2.9277 HRD-in -72.49, -52.56 71.47, 1.89 in-in-out SNCiio in-out ActLoopNT-in 2.8266 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.68, -53.4 APE9-dihe-na -81.9, 152.03 APE8-dihe-in -63.34, 145.38 APE8-rot-out 183.29 APE67-dihe-in -65.1, -32.1 -54.44, -34.81 APE12-dist-in 13.2337 APE11-dist-in 11.4246 APE10-dist-in 6.5603 APE9-dist-in 3.6129 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8buc Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUDB Q9NYV4 715 1043 1490.0 RP9:61101 Type1 Inactive DFGin 6.8061 15.4238 ABAminus -142.15, -16.91 -106.36, 87.13 -96.45, 32.21 289.44, 76.45 -77.57, -27.46 in-in in 8.0202 Saltbr-in 3.4896 HRD-in -66.52, -51.15 74.89, 1.88 in-in-in SNCiii in-in ActLoopNT-in 2.9309 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.04, -21.52 APE9-dihe-na -109.6, 155.4 APE8-dihe-in -62.09, 142.67 APE8-rot-in 309.35 APE67-dihe-in -60.6, -25.6 -60.57, -39.4 APE12-dist-in 13.1906 APE11-dist-in 11.7357 APE10-dist-in 6.6928 APE9-dist-in 3.6946 K965R TPO893 TPO893 XRAY 3.2 0.191 0.22 B 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bud Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUDH Q9NYV4 715 1043 1490.0 RP9:61101 Type1 Inactive DFGin 6.9462 15.3566 ABAminus -136.05, -39.21 -99.68, 89.69 -94.42, 33.08 285.78, 76.86 -80.16, -27.09 in-in in 7.932 Saltbr-in 3.0948 HRD-in -68.45, -57.7 74.71, 4.44 in-in-in SNCiii in-in ActLoopNT-in 2.8947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.74, -26.44 APE9-dihe-na -108.9, 157.16 APE8-dihe-in -60.21, 144.65 APE8-rot-in 297.94 APE67-dihe-in -60.44, -27.56 -58.25, -38.75 APE12-dist-in 13.6485 APE11-dist-in 11.7344 APE10-dist-in 7.1594 APE9-dist-in 3.6555 K965R TPO893 TPO893 XRAY 3.2 0.191 0.22 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bud Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUEH Q9NYV4 715 1043 1490.0 RVU:61101 Type1 Inactive DFGin 6.9533 15.5282 ABAminus -135.4, -31.77 -104.88, 88.01 -89.97, 37.83 286.95, 75.03 -83.73, -24.85 in-in in 8.0945 Saltbr-in 3.0534 HRD-in -72.11, -58.45 75.28, 1.16 in-in-in SNCiii in-in ActLoopNT-in 2.9141 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.38, -30.92 APE9-dihe-na -101.17, 153.28 APE8-dihe-in -59.63, 146.59 APE8-rot-in 309.03 APE67-dihe-in -63.21, -32.83 -55.37, -40.46 APE12-dist-in 13.5206 APE11-dist-in 11.6573 APE10-dist-in 6.9037 APE9-dist-in 3.3499 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bue Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUIB Q9NYV4 715 1041 1490.0 RV6:1101 Type1 Inactive DFGin 6.8484 15.3849 ABAminus -131.36, -62.29 -89.48, 101.04 -94.93, 20.15 285.65, 74.39 -62.98, -21.99 in-in in 8.0628 Saltbr-in 3.2441 HRD-out -78.21, 99.43 -82.66, -35.16 in-in-in SNCiii in-in ActLoopNT-in 3.1675 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.84, -19.18 APE9-dihe-na -128.33, 156.07 APE8-dihe-in -65.63, 140.55 APE8-rot-in 297.93 APE67-dihe-in -59.87, -34.95 -53.39, -43.04 APE12-dist-in 13.3654 APE11-dist-in 10.9607 APE10-dist-in 7.2526 APE9-dist-in 4.181 K965R TPO893 TPO893 XRAY 3.5 0.184 0.221 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bui Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUIH Q9NYV4 715 1038 1490.0 RV6:1101 Type1 Inactive DFGin 6.9697 15.2814 ABAminus -131.92, -50.63 -89.53, 95.29 -98.99, 14.99 287.64, 76.53 -67.14, -30.95 in-in in 8.1508 Saltbr-in 3.2771 HRD-out -79.19, 77.36 -62.47, -39.48 in-in-in SNCiii in-in ActLoopNT-in 2.9931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.57, -18.14 APE9-dihe-na -112.45, 157.67 APE8-dihe-in -65.3, 140.25 APE8-rot-in 297.23 APE67-dihe-in -58.21, -35.12 -53.14, -43.81 APE12-dist-in 13.665 APE11-dist-in 11.5249 APE10-dist-in 7.0045 APE9-dist-in 3.8741 K965R TPO893 TPO893 XRAY 3.5 0.184 0.221 H 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bui Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BULH Q9NYV4 715 1034 1490.0 RSU:1101 Type1 Inactive DFGin 7.0023 15.3341 ABAminus -135.61, -41.73 -99.52, 91.67 -88.52, 15.79 285.0, 79.41 -60.56, -30.48 in-in in 7.861 Saltbr-in 2.9464 HRD-in -71.18, -53.58 72.73, 2.44 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.32, -27.33 APE9-dihe-na -113.19, 154.32 APE8-dihe-in -60.54, 141.61 APE8-rot-in 300.72 APE67-dihe-in -58.89, -38.82 -52.85, -42.63 APE12-dist-in 13.5001 APE11-dist-in 11.612 APE10-dist-in 7.1824 APE9-dist-in 3.8181 None TPO893 TPO893 XRAY 3.4 0.179 0.215 H 344.0 320.0 0 29 29 0 [[727, 1020]] 1.0 8bul Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUNB Q9NYV4 715 1041 1490.0 RNF:61101 Type1 Inactive DFGin 7.0092 15.2967 ABAminus -131.36, -49.43 -89.83, 91.44 -92.44, 32.63 287.3, 77.5 -75.27, -18.22 in-in in 7.7476 Saltbr-in 3.2793 HRD-in -75.67, -53.71 75.4, -0.11 in-in-in SNCiii in-in ActLoopNT-in 2.9232 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.12, -39.12 APE9-dihe-na -104.98, 151.97 APE8-dihe-in -58.93, 142.91 APE8-rot-in 279.94 APE67-dihe-in -65.42, -33.6 -55.06, -35.14 APE12-dist-in 13.3877 APE11-dist-in 11.6951 APE10-dist-in 7.099 APE9-dist-in 3.6569 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bun Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUNH Q9NYV4 715 1043 1490.0 RNF:61101 Type1 Inactive DFGin 7.0453 15.2864 ABAminus -125.24, -50.09 -100.69, 94.75 -92.24, 30.97 286.18, 71.82 -75.42, -18.26 in-in in 7.8338 Saltbr-in 3.3735 HRD-in -77.6, -54.36 73.0, -1.25 in-in-in SNCiii in-in ActLoopNT-in 2.74 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.56, -41.65 APE9-dihe-na -95.79, 153.05 APE8-dihe-in -58.87, 144.43 APE8-rot-in 305.25 APE67-dihe-in -65.98, -31.29 -55.83, -37.71 APE12-dist-in 13.7752 APE11-dist-in 11.9719 APE10-dist-in 6.9568 APE9-dist-in 3.4785 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bun Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUOB Q9NYV4 715 1040 1490.0 RLC:1101 Type1 Inactive DFGin 6.577 15.6443 ABAminus -146.64, 39.95 -136.73, 75.69 -99.12, 16.92 290.75, 79.72 -67.9, -33.68 in-in in 8.2125 Saltbr-in 2.831 HRD-in -67.45, -41.41 63.58, -11.91 in-in-in SNCiii in-in ActLoopNT-in 2.9789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.89, -24.96 APE9-dihe-na -114.96, 153.64 APE8-dihe-in -59.59, 137.04 APE8-rot-in 298.26 APE67-dihe-in -58.73, -33.95 -50.83, -38.96 APE12-dist-in 13.2777 APE11-dist-in 11.4095 APE10-dist-in 7.0434 APE9-dist-in 3.9158 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 B 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8buo Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BURE Q9NYV4 715 1040 1490.0 RQU:61101 Type1 Inactive DFGin 6.8845 15.8442 ABAminus -134.08, -49.7 -100.21, 93.56 -92.36, 24.23 284.18, 80.41 -66.46, -36.08 in-in in 8.2155 Saltbr-in 2.802 HRD-in -63.9, -48.8 70.15, 6.43 in-in-out SNCiio in-out ActLoopNT-in 2.9274 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -92.25, -40.02 APE9-dihe-na -84.05, 150.42 APE8-dihe-in -60.84, 144.54 APE8-rot-out 183.23 APE67-dihe-in -64.31, -32.85 -49.71, -40.37 APE12-dist-in 12.2442 APE11-dist-in 11.971 APE10-dist-in 6.5332 APE9-dist-in 3.8503 K965R TPO893 TPO893 XRAY 3.64 0.192 0.234 E 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8bur Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUSH Q9NYV4 715 1044 1490.0 RMX:1101 Type1 Inactive DFGin 6.901 15.0688 ABAminus -143.82, 12.24 -131.03, 98.54 -110.73, 33.01 294.28, 70.2 -74.22, -18.61 in-in in 7.9468 Saltbr-in 3.1237 HRD-in -74.26, -49.18 68.04, 9.28 in-in-in SNCiii in-in ActLoopNT-in 2.8467 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -102.73, -48.18 APE9-dihe-na -92.8, 152.41 APE8-dihe-in -59.01, 141.68 APE8-rot-in 303.45 APE67-dihe-in -64.79, -31.26 -52.5, -37.48 APE12-dist-in 13.6606 APE11-dist-in 11.9862 APE10-dist-in 7.1999 APE9-dist-in 3.7373 K965R TPO893 TPO893 XRAY 3.26 0.209 0.228 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bus Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUTB Q9NYV4 715 1039 1490.0 RQ5:61101 Type1 Inactive DFGin 7.0564 15.3959 ABAminus -130.15, -50.58 -94.08, 102.79 -101.3, 34.01 287.2, 80.24 -71.28, -33.81 in-in in 8.1776 Saltbr-in 3.454 HRD-in -68.35, -50.74 72.26, 0.96 in-in-out SNCiio in-out ActLoopNT-in 2.8548 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -102.11, -52.89 APE9-dihe-na -83.71, 152.96 APE8-dihe-in -63.18, 146.03 APE8-rot-out 183.88 APE67-dihe-in -64.84, -30.01 -53.45, -39.74 APE12-dist-in 13.1524 APE11-dist-in 11.7525 APE10-dist-in 6.8757 APE9-dist-in 3.6644 K965R TPO893 TPO893 XRAY 3.25 0.198 0.217 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8but Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUTH Q9NYV4 715 1043 1490.0 RQ5:61101 Type1 Inactive DFGin 7.0927 15.4205 ABAminus -128.56, -49.4 -93.56, 100.15 -99.66, 30.54 282.78, 78.32 -73.44, -31.71 in-in in 8.0901 Saltbr-in 3.5145 HRD-in -72.59, -52.14 71.01, -0.2 in-in-in SNCiii in-in ActLoopNT-in 2.7456 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -103.31, -52.45 APE9-dihe-na -84.96, 155.97 APE8-dihe-in -63.11, 145.04 APE8-rot-in 301.85 APE67-dihe-in -65.27, -28.99 -54.91, -40.74 APE12-dist-in 13.688 APE11-dist-in 12.0303 APE10-dist-in 7.147 APE9-dist-in 3.4886 K965R TPO893 TPO893 XRAY 3.25 0.198 0.217 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8but Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 7NXKA Q9NYV4 715 1040 1490.0 UUB:2000 Type1 Inactive DFGin 7.3995 15.4871 ABAminus -95.46, -72.72 -129.88, 136.0 -106.22, 48.24 290.77, 75.67 -65.42, -30.99 in-none in 8.908 Saltbr-none 999.0 HRD-out -77.5, 146.77 -128.84, 17.49 none-in-out SNCnio in-out ActLoopNT-in 2.9696 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.63, -48.96 APE9-dihe-na -98.39, 153.96 APE8-dihe-in -58.36, 147.85 APE8-rot-out 42.54 APE67-dihe-in -71.34, -26.96 -59.32, -29.48 APE12-dist-in 12.8425 APE11-dist-in 11.1162 APE10-dist-in 6.7497 APE9-dist-in 3.4451 None TPO893 TPO893 XRAY 3.0 0.222 0.264 A 351.0 322.0 4 29 29 0 [[727, 1020]] 1.0 7nxk Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 9FMRE Q9NYV4 714 1042 1490.0 RMF:61101 Type1 Inactive DFGin 6.7935 14.6403 ABAminus -113.83, -79.52 -84.15, 118.47 -115.27, 16.16 293.54, 100.02 -64.02, -34.33 in-out in 9.6335 Saltbr-out 3.6123 HRD-out -79.17, 82.22 -59.96, 8.89 out-in-out SNCoio in-out ActLoopNT-in 3.0256 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -148.14, -27.51 APE9-dihe-na -104.44, 148.12 APE8-dihe-in -51.45, 137.55 APE8-rot-in 306.02 APE67-dihe-in -70.5, -21.3 -54.61, -36.19 APE12-dist-out 14.2984 APE11-dist-in 12.2112 APE10-dist-in 7.469 APE9-dist-in 3.7666 None TPO893 TPO893 XRAY 3.9 0.209 0.25 E 351.0 329.0 0 29 29 0 [[727, 1020]] 1.0 9fmr Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 9FMRH Q9NYV4 714 1044 1490.0 RMF:61101 Type1 Inactive DFGin 6.8012 14.6033 ABAminus -113.95, -78.4 -84.85, 124.02 -118.87, 17.95 291.29, 89.7 -63.88, -35.4 in-in in 8.5917 Saltbr-in 3.5517 HRD-in -72.47, -40.65 59.82, 5.57 in-in-in SNCiii in-in ActLoopNT-in 2.9439 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.74, -27.71 APE9-dihe-na -103.25, 148.34 APE8-dihe-in -51.07, 136.63 APE8-rot-in 306.14 APE67-dihe-in -69.99, -21.15 -54.39, -34.8 APE12-dist-in 13.8232 APE11-dist-in 12.0979 APE10-dist-in 7.2545 APE9-dist-in 3.6076 None TPO893 TPO893 XRAY 3.9 0.209 0.25 H 351.0 331.0 0 29 29 0 [[727, 1020]] 1.0 9fmr Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 4CXAA Q9NYV4 718 1050 1490.0 ANP:2051 ATPlike Inactive DFGin 6.4362 15.0223 BLAminus -127.47, 178.63 59.83, 84.78 -103.34, 39.58 291.64, 72.71 -78.99, -14.54 in-in in 8.1775 Saltbr-in 2.5134 HRD-in -89.68, -50.66 63.81, 17.68 in-in-out SNCiio in-out ActLoopNT-in 2.7933 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.43, 159.2 APE9-dihe-na 63.92, 139.76 APE8-dihe-in -56.37, 145.01 APE8-rot-out 63.76 APE67-dihe-in -64.68, -22.99 -55.23, -40.79 APE12-dist-in 13.2123 APE11-dist-in 11.6623 APE10-dist-in 7.3626 APE9-dist-in 3.5055 None TPO893 TPO893 XRAY 3.15 0.224 0.279 A 340.0 330.0 3 29 28 1 [[727, 1020]] 1.0 4cxa Homo sapiens CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 4NSTA Q9NYV4 716 1046 1490.0 ADP:1101 ATPlike Inactive DFGin 6.9783 15.1109 BLAminus -127.54, 179.84 60.58, 76.06 -95.3, 23.79 283.73, 86.71 -65.43, -16.77 in-in in 8.9881 Saltbr-in 3.0309 HRD-in -82.28, -56.37 71.8, 9.39 in-in-out SNCiio in-out ActLoopNT-in 2.9558 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.59, 153.12 APE9-dihe-na 76.09, 132.29 APE8-dihe-in -60.41, 149.83 APE8-rot-out 85.48 APE67-dihe-in -64.83, -28.79 -60.07, -39.7 APE12-dist-in 13.2466 APE11-dist-in 11.2727 APE10-dist-in 6.9953 APE9-dist-in 3.4606 None TPO893 TPO893 XRAY 2.2 0.198 0.24 A 351.0 323.0 8 29 29 0 [[727, 1020]] 1.0 4nst Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 4NSTC Q9NYV4 717 1045 1490.0 ADP:1101 ATPlike Inactive DFGin 6.9718 15.1681 BLAminus -122.49, -178.57 55.97, 75.42 -92.86, 20.68 283.24, 86.31 -56.98, -20.08 in-in in 8.8631 Saltbr-in 2.9569 HRD-in -69.12, -51.54 66.96, 15.75 in-in-out SNCiio in-out ActLoopNT-in 2.9277 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.74, 152.42 APE9-dihe-na 82.09, 126.12 APE8-dihe-in -62.22, 152.62 APE8-rot-out 78.32 APE67-dihe-in -63.16, -30.08 -57.73, -42.25 APE12-dist-in 13.2024 APE11-dist-in 11.2673 APE10-dist-in 6.9416 APE9-dist-in 3.7053 None TPO893 TPO893 XRAY 2.2 0.198 0.24 C 351.0 318.0 11 29 28 1 [[727, 1020]] 1.0 4nst Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 4UN0C Q9NYV4 719 1036 1490.0 No_ligand No_ligand Inactive DFGin 7.2318 15.5034 BLAminus -124.23, -178.57 61.68, 76.73 -100.84, 26.92 286.01, 6.79 -65.68, -44.77 in-none in 8.9953 Saltbr-none 999.0 HRD-in -69.99, -50.49 63.23, 23.44 none-in-out SNCnio in-out ActLoopNT-in 2.9363 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -139.84, 155.57 APE9-dihe-na 72.34, -14.08 APE8-dihe-out 67.52, 158.6 APE8-rot-out 70.66 APE67-dihe-in -58.83, -37.69 -56.4, -50.16 APE12-dist-in 13.1272 APE11-dist-in 10.7644 APE10-dist-in 7.9437 APE9-dist-in 3.9269 None TPO893 TPO893 XRAY 3.15 0.217 0.271 C 326.0 309.0 9 29 29 0 [[727, 1020]] 1.0 4un0 Homo sapiens CMGC_CDK12_HUMAN CMGC 2.2e-84 289.2 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 4UN0D Q9NYV4 723 1024 1490.0 No_ligand No_ligand Inactive DFGin 7.1953 15.4696 BLAminus -123.96, -178.26 62.11, 76.94 -101.1, 26.4 286.66, 6.77 -66.07, -44.8 in-none in 8.9588 Saltbr-none 999.0 HRD-in -70.01, -50.55 63.3, 23.26 none-in-out SNCnio in-out ActLoopNT-in 2.8072 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -139.6, 156.23 APE9-dihe-na 75.54, -12.58 APE8-dihe-out 66.76, 157.7 APE8-rot-out 70.35 APE67-dihe-in -58.41, -37.99 -56.68, -49.87 APE12-dist-in 13.2106 APE11-dist-in 11.101 APE10-dist-in 7.9718 APE9-dist-in 3.9556 None TPO893 TPO893 XRAY 3.15 0.217 0.271 D 326.0 277.0 25 29 24 5 [[727, 1020]] 1.0 4un0 Homo sapiens CMGC_CDK12_HUMAN CMGC 2.2e-84 289.2 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 4CXAC Q9NYV4 718 1048 1490.0 No_ligand No_ligand Inactive DFGin 7.1995 15.2477 BLAminus -126.07, 177.23 58.72, 82.97 -102.36, 37.62 286.53, 69.22 -80.81, -13.97 in-none in 8.0455 Saltbr-none 999.0 HRD-in -86.15, -47.73 62.33, 17.56 none-in-out SNCnio in-out ActLoopNT-in 3.0475 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.86, 161.73 APE9-dihe-na 68.73, 142.31 APE8-dihe-in -55.95, 146.27 APE8-rot-out 63.52 APE67-dihe-in -66.87, -27.84 -54.72, -39.98 APE12-dist-in 13.1798 APE11-dist-in 11.907 APE10-dist-in 7.4808 APE9-dist-in 3.5773 None TPO893 TPO893 XRAY 3.15 0.224 0.279 C 340.0 331.0 0 29 29 0 [[727, 1020]] 1.0 4cxa Homo sapiens CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU2E Q9NYV4 715 1039 1490.0 No_ligand No_ligand Inactive DFGin 7.3788 15.5698 BLAminus -136.39, 179.92 48.57, 72.52 -89.87, 33.71 279.3, 90.07 -78.07, -11.47 in-in in 7.9107 Saltbr-in 3.1471 HRD-in -74.54, -52.71 71.43, 6.76 in-in-out SNCiio in-out ActLoopNT-in 2.8692 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.65, -39.48 APE9-dihe-na -100.87, 155.56 APE8-dihe-in -58.32, 146.43 APE8-rot-out 175.64 APE67-dihe-in -62.37, -35.72 -53.25, -43.67 APE12-dist-in 13.3936 APE11-dist-in 12.5707 APE10-dist-in 7.1487 APE9-dist-in 3.7382 K965R TPO893 TPO893 XRAY 3.13 0.193 0.217 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu2 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUDE Q9NYV4 715 1043 1490.0 No_ligand No_ligand Inactive DFGin 7.2716 15.453 BLAminus -143.83, -177.07 47.13, 79.14 -96.0, 35.58 285.18, 78.34 -74.8, -28.12 in-in in 8.105 Saltbr-in 3.0752 HRD-in -66.78, -51.99 75.75, 3.43 in-in-out SNCiio in-out ActLoopNT-in 2.9854 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -100.45, -19.67 APE9-dihe-na -95.18, 153.43 APE8-dihe-in -60.73, 146.92 APE8-rot-out 173.58 APE67-dihe-in -62.46, -23.72 -59.64, -41.84 APE12-dist-in 13.0579 APE11-dist-in 12.4969 APE10-dist-in 6.7722 APE9-dist-in 3.4044 K965R TPO893 TPO893 XRAY 3.2 0.191 0.22 E 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bud Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUGE Q9NYV4 715 1039 1490.0 No_ligand No_ligand Inactive DFGin 7.5082 15.7435 BLAminus -142.95, -165.93 46.31, 64.06 -92.32, 17.1 280.22, 84.99 -61.9, -35.84 in-in in 8.2122 Saltbr-in 3.1127 HRD-in -63.09, -51.61 71.91, 6.47 in-in-out SNCiio in-out ActLoopNT-in 2.9558 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -74.97, -44.52 APE9-dihe-na -69.42, 151.3 APE8-dihe-in -61.28, 146.55 APE8-rot-out 168.8 APE67-dihe-in -63.35, -29.72 -54.01, -46.01 APE12-dist-in 13.2222 APE11-dist-in 12.7218 APE10-dist-in 6.9462 APE9-dist-in 3.4313 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bug Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 6B3EA Q9NYV4 717 1036 1490.0 CJM:1102 Type1 Inactive DFGin 7.202 14.7664 BLAminus -121.7, 178.92 59.35, 79.81 -95.65, 26.66 285.79, 81.49 -61.82, -29.55 in-in in 8.6992 Saltbr-in 3.05 HRD-in -76.48, -54.37 70.53, 12.96 in-in-out SNCiio in-out ActLoopNT-in 2.9145 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.0, 155.78 APE9-dihe-na 76.06, 131.42 APE8-dihe-in -60.49, 145.1 APE8-rot-out 86.32 APE67-dihe-in -63.58, -25.36 -47.54, -46.44 APE12-dist-in 13.3552 APE11-dist-in 11.458 APE10-dist-in 6.9768 APE9-dist-in 3.4966 None TPO893 TPO893 XRAY 3.06 0.191 0.212 A 320.0 310.0 10 29 29 0 [[727, 1020]] 1.0 6b3e Homo sapiens CMGC_CDK12_HUMAN CMGC 2e-84 289.3 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 6B3EC Q9NYV4 719 1036 1490.0 CJM:1103 Type1 Inactive DFGin 7.173 14.6207 BLAminus -121.27, -179.9 57.69, 80.64 -96.21, 26.0 285.96, 80.56 -59.62, -30.89 in-in in 8.5283 Saltbr-in 2.8376 HRD-in -74.96, -53.91 69.51, 14.07 in-in-out SNCiio in-out ActLoopNT-in 2.8936 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.93, 154.64 APE9-dihe-na 78.03, 130.48 APE8-dihe-in -61.1, 145.82 APE8-rot-out 85.07 APE67-dihe-in -62.57, -25.75 -47.61, -47.19 APE12-dist-in 13.2674 APE11-dist-in 11.359 APE10-dist-in 6.9435 APE9-dist-in 3.5617 None TPO893 TPO893 XRAY 3.06 0.191 0.212 C 320.0 308.0 10 29 29 0 [[727, 1020]] 1.0 6b3e Homo sapiens CMGC_CDK12_HUMAN CMGC 2e-84 289.3 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 5ACBC Q9NYV4 716 1040 1490.0 5I1:2000 Type1 Inactive DFGin 7.4424 15.98 BLAminus -120.77, 171.13 69.09, 68.44 -91.07, 27.42 288.67, 78.45 -57.05, -52.5 in-in in 8.3689 Saltbr-in 2.8783 HRD-in -75.39, -52.07 67.69, 20.88 in-in-out SNCiio in-out ActLoopNT-in 2.8043 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.05, 158.72 APE9-dihe-na 71.72, 133.31 APE8-dihe-in -62.63, 141.8 APE8-rot-out 192.05 APE67-dihe-in -62.93, -27.37 -47.97, -41.23 APE12-dist-in 13.6417 APE11-dist-in 11.6664 APE10-dist-in 7.3938 APE9-dist-in 3.5299 None TPO893 TPO893 XRAY 2.7 0.223 0.262 C 340.0 325.0 0 29 29 0 [[727, 1020]] 1.0 5acb Homo sapiens CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 5ACBD Q9NYV4 718 1044 1490.0 5I1:2000 Type1 Inactive DFGin 7.4517 16.0111 BLAminus -121.14, 171.65 68.87, 69.17 -92.34, 27.19 288.77, 78.24 -58.4, -50.08 in-in in 8.349 Saltbr-in 2.8748 HRD-in -75.87, -51.87 67.36, 21.14 in-in-out SNCiio in-out ActLoopNT-in 2.8109 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.18, 158.62 APE9-dihe-na 71.07, 133.26 APE8-dihe-in -63.22, 142.55 APE8-rot-out 191.44 APE67-dihe-in -63.33, -26.97 -48.15, -41.58 APE12-dist-in 13.6981 APE11-dist-in 11.7681 APE10-dist-in 7.4862 APE9-dist-in 3.5674 None TPO893 TPO893 XRAY 2.7 0.223 0.262 D 340.0 320.0 7 29 26 3 [[727, 1020]] 1.0 5acb Homo sapiens CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 9JK1A Q9NYV4 717 1039 1490.0 A1EB3:1202 Type1 Inactive DFGin 7.136 16.1944 BLAminus -133.53, 173.61 54.27, 71.41 -88.96, 16.92 270.96, 77.73 -63.15, -30.31 in-in in 8.4971 Saltbr-in 3.2847 HRD-in -81.17, -44.88 64.66, 14.44 in-in-out SNCiio in-out ActLoopNT-in 2.8569 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.0, -26.54 APE9-dihe-na -103.25, 143.89 APE8-dihe-in -52.76, 144.9 APE8-rot-out 169.48 APE67-dihe-in -66.06, -18.64 -58.71, -34.25 APE12-dist-in 13.7501 APE11-dist-in 12.2647 APE10-dist-in 7.1765 APE9-dist-in 3.888 None TPO893 TPO893 XRAY 2.72 0.249 0.267 A 340.0 311.0 12 29 27 2 [[727, 1020]] 1.0 9jk1 Homo sapiens CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 9JK1B Q9NYV4 715 1039 1490.0 A1EB3:1101 Type1 Inactive DFGin 6.9737 15.7959 BLAminus -131.76, 174.62 55.08, 70.72 -88.19, 16.31 271.01, 79.18 -62.74, -29.13 in-in in 8.5172 Saltbr-in 3.0362 HRD-in -81.5, -44.39 65.05, 13.56 in-in-out SNCiio in-out ActLoopNT-in 3.1501 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.88, -41.9 APE9-dihe-na -106.09, 143.29 APE8-dihe-in -52.94, 146.84 APE8-rot-out 167.82 APE67-dihe-in -65.97, -16.6 -59.29, -37.44 APE12-dist-in 13.6164 APE11-dist-in 11.5844 APE10-dist-in 7.2432 APE9-dist-in 3.6611 None TPO893 TPO893 XRAY 2.72 0.249 0.267 B 340.0 315.0 10 29 29 0 [[727, 1020]] 1.0 9jk1 Homo sapiens CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 6TD3B Q9NYV4 715 1047 1490.0 RC8:1101 Type1 Inactive DFGin 7.0715 15.3763 BLAminus -144.85, 177.87 66.18, 66.81 -86.27, 29.11 284.0, 81.86 -68.57, -26.95 in-in in 7.9403 Saltbr-in 3.0983 HRD-in -75.0, -46.5 66.33, 3.67 in-in-out SNCiio in-out ActLoopNT-in 2.9625 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.74, 152.33 APE9-dihe-na 70.44, 153.31 APE8-dihe-in -72.7, 152.08 APE8-rot-out 190.09 APE67-dihe-in -62.32, -35.85 -49.81, -38.44 APE12-dist-in 13.58 APE11-dist-in 10.9935 APE10-dist-in 7.1532 APE9-dist-in 3.6429 K965R TPO893 TPO893 XRAY 3.46 0.195 0.22 B 344.0 333.0 0 29 29 0 [[727, 1020]] 1.0 6td3 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 6TD3H Q9NYV4 715 1047 1490.0 RC8:1101 Type1 Inactive DFGin 7.0079 15.0671 BLAminus -125.85, 165.87 77.73, 76.18 -92.06, 29.13 290.22, 73.9 -71.24, -38.15 in-in in 7.8983 Saltbr-in 3.0731 HRD-in -75.01, -45.87 63.18, 11.24 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -152.2, 169.13 APE9-dihe-na 75.43, 19.72 APE8-dihe-out 60.33, 162.48 APE8-rot-out 98.13 APE67-dihe-in -64.24, -27.06 -78.21, -44.67 APE12-dist-in 13.9046 APE11-dist-in 11.9021 APE10-dist-in 7.407 APE9-dist-in 3.189 K965R TPO893 TPO893 XRAY 3.46 0.195 0.22 H 344.0 333.0 0 29 29 0 [[727, 1020]] 1.0 6td3 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU1E Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 7.0678 15.2145 BLAminus -136.12, -177.54 44.75, 87.14 -99.51, 30.27 285.35, 73.68 -68.31, -25.33 in-in in 7.7936 Saltbr-in 3.0999 HRD-in -77.94, -49.77 74.02, -0.64 in-in-out SNCiio in-out ActLoopNT-in 2.6913 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.97, -45.94 APE9-dihe-na -80.52, 149.74 APE8-dihe-in -60.97, 145.17 APE8-rot-out 178.02 APE67-dihe-in -66.77, -27.56 -51.22, -43.09 APE12-dist-in 13.0179 APE11-dist-in 12.2266 APE10-dist-in 6.9915 APE9-dist-in 3.5494 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 E 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu1 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU4E Q9NYV4 715 1039 1490.0 RQL:61101 Type1 Inactive DFGin 7.468 15.54 BLAminus -141.1, 177.81 60.96, 67.17 -93.67, 20.14 286.75, 91.51 -68.13, -33.02 in-out in 8.589 Saltbr-out 5.3781 HRD-in -65.76, -60.59 77.41, 5.82 out-in-out SNCoio in-out ActLoopNT-in 3.0295 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -92.44, -31.45 APE9-dihe-na -85.2, 150.66 APE8-dihe-in -60.73, 147.65 APE8-rot-out 173.82 APE67-dihe-in -63.61, -27.41 -58.33, -41.33 APE12-dist-in 13.0819 APE11-dist-in 12.5962 APE10-dist-in 6.8982 APE9-dist-in 3.368 K965R TPO893 TPO893 XRAY 3.09 0.205 0.223 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu4 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU6E Q9NYV4 715 1038 1490.0 RQE:61101 Type1 Inactive DFGin 6.9042 14.7933 BLAminus -142.16, 173.3 46.61, 77.13 -86.78, 22.75 290.79, 69.64 -59.06, -38.89 in-out in 8.4663 Saltbr-out 3.7793 HRD-in -71.31, -54.36 76.0, -0.16 out-in-out SNCoio in-out ActLoopNT-in 2.9818 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -121.41, -43.86 APE9-dihe-na -68.68, 149.74 APE8-dihe-in -53.47, 142.92 APE8-rot-out 167.33 APE67-dihe-in -57.01, -34.74 -57.51, -41.34 APE12-dist-in 13.1034 APE11-dist-in 13.0819 APE10-dist-in 7.1799 APE9-dist-in 3.5468 K965R TPO893 TPO893 XRAY 3.45 0.219 0.249 E 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bu6 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU7E Q9NYV4 715 1043 1490.0 RS5:1101 Type1 Inactive DFGin 6.9129 15.3311 BLAminus -151.87, 179.81 58.39, 58.15 -75.44, 35.18 288.34, 71.23 -65.18, -38.03 in-in in 7.7566 Saltbr-in 2.771 HRD-in -65.82, -48.21 71.8, 2.22 in-in-out SNCiio in-out ActLoopNT-in 2.8804 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -76.27, -35.49 APE9-dihe-na -79.69, 146.79 APE8-dihe-in -61.33, 142.24 APE8-rot-out 178.46 APE67-dihe-in -63.9, -29.29 -50.85, -42.32 APE12-dist-in 12.5269 APE11-dist-in 12.3359 APE10-dist-in 6.449 APE9-dist-in 3.4892 K965R TPO893 TPO893 XRAY 3.245 0.193 0.219 E 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bu7 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU9E Q9NYV4 715 1039 1490.0 RRC:61101 Type1 Inactive DFGin 6.9943 15.2956 BLAminus -144.01, 174.3 58.02, 76.59 -92.29, 23.22 284.15, 79.53 -66.56, -16.01 in-in in 7.9265 Saltbr-in 2.9785 HRD-in -72.29, -52.87 75.22, 4.09 in-in-out SNCiio in-out ActLoopNT-in 2.9527 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -79.11, -41.8 APE9-dihe-na -74.19, 150.88 APE8-dihe-in -62.82, 143.67 APE8-rot-out 166.93 APE67-dihe-in -61.65, -28.3 -55.31, -42.74 APE12-dist-in 13.0026 APE11-dist-in 12.7132 APE10-dist-in 6.8922 APE9-dist-in 3.4751 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUBB Q9NYV4 715 1041 1490.0 RNU:61101 Type1 Inactive DFGin 7.183 15.8614 BLAminus -140.81, -179.71 59.34, 42.69 -57.7, -43.03 281.93, 72.19 -135.84, 169.59 in-in in 7.8158 Saltbr-in 3.0301 HRD-out -85.59, 106.33 -67.25, -35.7 in-out-out SNCioo out-out ActLoopNT-out 15.0827 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -58.9, -41.94 APE9-dihe-na -63.9, -43.28 APE8-dihe-out -57.35, -36.53 APE8-rot-in 303.78 APE67-dihe-in -55.9, -22.59 -60.27, -40.25 APE12-dist-in 10.517 APE11-dist-in 13.5215 APE10-dist-out 17.3786 APE9-dist-out 11.733 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bub Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUBE Q9NYV4 715 1043 1490.0 RNU:61101 Type1 Inactive DFGin 7.1209 15.7177 BLAminus -151.03, 179.83 54.33, 46.25 -61.28, -40.39 279.04, 68.48 -138.85, 169.0 in-in in 8.2609 Saltbr-in 2.9133 HRD-out -90.61, 99.83 -68.22, -35.13 in-out-out SNCioo out-out ActLoopNT-out 14.6238 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -60.24, -43.43 APE9-dihe-na -66.88, -44.0 APE8-dihe-out -57.36, -41.95 APE8-rot-in 294.1 APE67-dihe-in -53.67, -21.91 -61.1, -39.92 APE12-dist-in 10.606 APE11-dist-out 14.7928 APE10-dist-out 17.9151 APE9-dist-out 11.2983 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 E 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bub Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUCE Q9NYV4 715 1039 1490.0 RKO:61101 Type1 Inactive DFGin 7.2362 15.3346 BLAminus -141.04, 176.79 52.98, 78.31 -91.94, 30.22 286.84, 76.41 -65.41, -31.19 in-in in 7.9609 Saltbr-in 2.9083 HRD-in -69.25, -49.18 71.49, 1.27 in-in-out SNCiio in-out ActLoopNT-in 2.8699 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -94.07, -41.15 APE9-dihe-na -76.31, 151.65 APE8-dihe-in -63.11, 145.53 APE8-rot-out 179.86 APE67-dihe-in -66.95, -27.99 -55.33, -37.54 APE12-dist-in 12.9962 APE11-dist-in 12.5405 APE10-dist-in 6.8001 APE9-dist-in 3.4636 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8buc Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUEE Q9NYV4 715 1039 1490.0 RVU:61101 Type1 Inactive DFGin 7.242 15.4962 BLAminus -141.72, -174.7 47.09, 73.46 -90.8, 38.01 284.87, 78.5 -78.36, -22.84 in-in in 7.9834 Saltbr-in 3.3242 HRD-in -72.61, -56.11 78.07, 3.62 in-in-out SNCiio in-out ActLoopNT-in 2.8628 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -101.94, -25.35 APE9-dihe-na -96.92, 153.79 APE8-dihe-in -59.83, 147.51 APE8-rot-out 172.74 APE67-dihe-in -64.75, -28.9 -55.27, -41.29 APE12-dist-in 12.9803 APE11-dist-in 12.541 APE10-dist-in 7.0055 APE9-dist-in 3.3709 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bue Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUFE Q9NYV4 715 1043 1490.0 RW6:61101 Type1 Inactive DFGin 7.2357 15.6133 BLAminus -139.81, -179.98 50.46, 82.76 -97.71, 35.51 286.32, 76.93 -72.96, -20.08 in-in in 8.2072 Saltbr-in 3.0835 HRD-in -73.52, -52.81 75.99, 1.49 in-in-out SNCiio in-out ActLoopNT-in 3.1387 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -94.42, -47.71 APE9-dihe-na -72.58, 149.04 APE8-dihe-in -62.45, 149.79 APE8-rot-out 175.62 APE67-dihe-in -64.49, -29.41 -54.77, -42.48 APE12-dist-in 12.6293 APE11-dist-in 12.3452 APE10-dist-in 6.6156 APE9-dist-in 3.2815 K965R TPO893 TPO893 XRAY 3.3 0.185 0.22 E 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8buf Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUHE Q9NYV4 715 1034 1490.0 RR9:61101 Type1 Inactive DFGin 7.1857 15.7288 BLAminus -148.68, -172.98 46.52, 61.7 -84.29, 18.93 287.47, 71.85 -64.36, -25.08 in-in in 8.2922 Saltbr-in 3.1458 HRD-in -67.53, -47.52 70.08, 2.73 in-in-out SNCiio in-out ActLoopNT-in 2.9549 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -76.87, -40.28 APE9-dihe-na -73.29, 157.3 APE8-dihe-in -67.11, 147.48 APE8-rot-out 173.32 APE67-dihe-in -62.13, -36.27 -57.69, -39.06 APE12-dist-in 13.3694 APE11-dist-in 12.874 APE10-dist-in 7.0861 APE9-dist-in 3.4867 K965R TPO893 TPO893 XRAY 3.79 0.189 0.232 E 344.0 320.0 0 29 29 0 [[727, 1020]] 1.0 8buh Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUIE Q9NYV4 715 1039 1490.0 RV6:1101 Type1 Inactive DFGin 7.5392 15.5582 BLAminus -143.87, -178.18 39.61, 79.76 -92.26, 22.29 284.74, 80.02 -58.61, -17.16 in-out in 8.1098 Saltbr-out 3.7147 HRD-out -75.62, 149.49 -131.37, 158.61 out-in-out SNCoio in-out ActLoopNT-in 3.1665 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -99.18, -17.3 APE9-dihe-na -88.48, 155.1 APE8-dihe-in -64.43, 139.92 APE8-rot-out 15.61 APE67-dihe-in -61.18, -34.77 -50.17, -41.15 APE12-dist-in 13.0189 APE11-dist-in 12.9143 APE10-dist-in 7.0194 APE9-dist-out 6.0272 K965R TPO893 TPO893 XRAY 3.5 0.184 0.221 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bui Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUJE Q9NYV4 715 1043 1490.0 RUW:1101 Type1 Inactive DFGin 7.4026 15.5591 BLAminus -141.86, -179.96 50.47, 61.92 -80.29, 20.39 278.49, 79.05 -71.07, 143.46 in-out in 7.788 Saltbr-out 4.3749 HRD-in -62.58, -56.77 78.09, -0.63 out-in-in SNCoii in-in ActLoopNT-in 3.0989 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.26, -45.94 APE9-dihe-na -81.75, 154.86 APE8-dihe-in -61.95, 146.07 APE8-rot-in 291.01 APE67-dihe-in -60.95, -32.29 -58.05, -37.51 APE12-dist-in 12.7922 APE11-dist-in 12.1761 APE10-dist-in 7.0857 APE9-dist-in 3.4301 K965R TPO893 TPO893 XRAY 3.62 0.164 0.206 E 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8buj Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUKE Q9NYV4 715 1039 1490.0 RWE:61101 Type1 Inactive DFGin 7.1266 15.2054 BLAminus -148.82, 179.05 51.44, 70.31 -90.34, 37.33 288.85, 69.46 -77.88, -21.75 in-in in 8.1145 Saltbr-in 2.9551 HRD-in -69.03, -55.19 75.3, 6.2 in-in-out SNCiio in-out ActLoopNT-in 3.0685 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -77.16, -37.78 APE9-dihe-na -75.17, 151.97 APE8-dihe-in -63.51, 147.07 APE8-rot-out 163.95 APE67-dihe-in -64.24, -27.64 -56.09, -42.19 APE12-dist-in 12.8427 APE11-dist-in 12.4198 APE10-dist-in 6.5654 APE9-dist-in 3.319 K965R TPO893 TPO893 XRAY 3.41 0.186 0.21 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8buk Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUNE Q9NYV4 715 1039 1490.0 RNF:61101 Type1 Inactive DFGin 7.2173 15.3129 BLAminus -143.55, -179.06 50.55, 77.42 -92.12, 34.85 285.27, 76.47 -72.26, -18.51 in-in in 7.8237 Saltbr-in 3.0461 HRD-in -77.13, -53.65 75.0, -0.22 in-in-out SNCiio in-out ActLoopNT-in 2.9239 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.31, -34.23 APE9-dihe-na -92.08, 151.91 APE8-dihe-in -57.84, 145.99 APE8-rot-out 175.35 APE67-dihe-in -65.98, -29.37 -55.72, -38.5 APE12-dist-in 13.1801 APE11-dist-in 12.6112 APE10-dist-in 7.008 APE9-dist-in 3.4323 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bun Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUOE Q9NYV4 715 1040 1490.0 RLC:1101 Type1 Inactive DFGin 6.9418 15.6202 BLAminus -143.37, -172.35 44.48, 74.17 -91.23, 22.68 280.06, 81.2 -62.03, -28.06 in-in in 8.0683 Saltbr-in 3.0558 HRD-out -76.67, 113.14 -91.39, -21.48 in-in-in SNCiii in-in ActLoopNT-in 2.8935 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.19, -25.24 APE9-dihe-na -90.88, 153.8 APE8-dihe-in -61.01, 138.91 APE8-rot-in 296.79 APE67-dihe-in -57.07, -33.65 -55.69, -42.2 APE12-dist-in 12.5157 APE11-dist-in 12.5542 APE10-dist-in 6.8393 APE9-dist-in 3.7348 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 E 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8buo Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUPB Q9NYV4 715 1027 1490.0 RWN:61101 Type1 Inactive DFGin 7.3764 16.2917 BLAminus -145.67, -178.63 51.5, 56.05 -75.52, 21.8 268.89, 78.21 -77.2, 158.24 in-in in 7.988 Saltbr-in 3.5467 HRD-out -85.14, 78.87 -56.17, -33.42 in-in-in SNCiii in-in ActLoopNT-in 2.9459 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.18, -2.81 APE9-dihe-na -129.4, 158.55 APE8-dihe-in -65.53, 143.29 APE8-rot-in 297.85 APE67-dihe-in -63.16, -33.23 -55.07, -39.7 APE12-dist-in 12.6261 APE11-dist-in 11.3253 APE10-dist-in 6.9551 APE9-dist-in 4.0747 K965R TPO893 TPO893 XRAY 3.41 0.201 0.223 B 344.0 313.0 0 29 29 0 [[727, 1020]] 1.0 8bup Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUPE Q9NYV4 715 1027 1490.0 RWN:61101 Type1 Inactive DFGin 7.3717 15.5461 BLAminus -147.42, 179.7 52.21, 60.23 -77.56, 28.73 281.63, 90.36 -71.43, -13.64 in-in in 8.0342 Saltbr-in 3.2385 HRD-out -86.98, 107.75 -88.22, 168.06 in-in-out SNCiio in-out ActLoopNT-in 2.8945 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -126.76, -4.83 APE9-dihe-na -127.6, 153.97 APE8-dihe-in -68.53, 144.26 APE8-rot-out 182.45 APE67-dihe-in -60.96, -31.45 -55.15, -40.88 APE12-dist-in 12.5226 APE11-dist-in 11.3157 APE10-dist-in 6.9568 APE9-dist-out 6.0416 K965R TPO893 TPO893 XRAY 3.41 0.201 0.223 E 344.0 313.0 0 29 29 0 [[727, 1020]] 1.0 8bup Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUQB Q9NYV4 715 1039 1490.0 RQ9:61101 Type1 Inactive DFGin 6.9128 15.3011 BLAminus -151.69, -179.79 53.5, 72.83 -94.44, 24.81 291.0, 75.32 -66.25, -27.07 in-in in 8.2723 Saltbr-in 3.3021 HRD-in -68.63, -54.73 77.99, 1.83 in-in-out SNCiio in-out ActLoopNT-in 2.9427 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.29, -38.77 APE9-dihe-na -81.13, 155.19 APE8-dihe-in -64.33, 147.28 APE8-rot-out 195.9 APE67-dihe-in -60.12, -28.17 -56.8, -43.77 APE12-dist-in 13.5591 APE11-dist-in 12.0036 APE10-dist-in 6.4297 APE9-dist-in 3.5058 K965R TPO893 TPO893 XRAY 3.2 0.196 0.216 B 344.0 321.0 4 29 29 0 [[727, 1020]] 1.0 8buq Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUQE Q9NYV4 715 1027 1490.0 RQ9:61101 Type1 Inactive DFGin 7.3625 15.3415 BLAminus -149.68, 178.7 52.88, 71.39 -93.43, 23.22 287.54, 76.39 -69.29, -26.75 in-in in 8.1446 Saltbr-in 3.1498 HRD-in -69.4, -56.77 77.16, 3.04 in-in-out SNCiio in-out ActLoopNT-in 3.0159 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -114.18, -38.9 APE9-dihe-na -82.51, 153.34 APE8-dihe-in -63.97, 150.36 APE8-rot-out 173.3 APE67-dihe-in -60.97, -26.14 -55.24, -44.87 APE12-dist-in 13.1923 APE11-dist-in 12.4633 APE10-dist-in 6.9357 APE9-dist-in 3.3361 K965R TPO893 TPO893 XRAY 3.2 0.196 0.216 E 344.0 313.0 0 29 29 0 [[727, 1020]] 1.0 8buq Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BURB Q9NYV4 715 1044 1490.0 RQU:61101 Type1 Inactive DFGin 7.0125 15.984 BLAminus -143.02, -172.66 43.3, 72.03 -94.19, 20.72 281.71, 86.88 -65.05, -33.85 in-in in 8.3112 Saltbr-in 3.3362 HRD-in -64.7, -53.19 72.64, 8.15 in-in-out SNCiio in-out ActLoopNT-in 2.9707 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -98.84, -39.21 APE9-dihe-na -79.75, 149.9 APE8-dihe-in -61.25, 143.48 APE8-rot-out 176.27 APE67-dihe-in -64.0, -30.04 -50.29, -42.66 APE12-dist-in 13.2177 APE11-dist-in 12.7649 APE10-dist-in 7.1593 APE9-dist-in 3.4474 K965R TPO893 TPO893 XRAY 3.64 0.192 0.234 B 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bur Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUSB Q9NYV4 715 1039 1490.0 RMX:1101 Type1 Inactive DFGin 7.0766 15.7189 BLAminus -138.42, 166.28 73.44, 73.47 -93.1, 22.82 287.17, 80.09 -62.57, -33.79 in-in in 8.5069 Saltbr-in 3.3151 HRD-in -69.35, -51.21 75.34, 13.48 in-in-out SNCiio in-out ActLoopNT-in 3.0197 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -86.75, -38.52 APE9-dihe-na -91.11, 154.59 APE8-dihe-in -64.35, 150.44 APE8-rot-out 197.48 APE67-dihe-in -56.11, -29.02 -59.98, -43.72 APE12-dist-in 12.9904 APE11-dist-in 12.5587 APE10-dist-in 6.9784 APE9-dist-in 3.8707 K965R TPO893 TPO893 XRAY 3.26 0.209 0.228 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bus Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUTE Q9NYV4 715 1039 1490.0 RQ5:61101 Type1 Inactive DFGin 7.2983 15.3231 BLAminus -139.51, -178.35 41.51, 85.24 -101.61, 29.69 285.9, 80.14 -70.78, -30.56 in-in in 8.259 Saltbr-in 3.086 HRD-in -67.79, -50.31 72.32, 0.48 in-in-out SNCiio in-out ActLoopNT-in 2.9303 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -100.83, -40.87 APE9-dihe-na -77.17, 152.92 APE8-dihe-in -63.05, 147.04 APE8-rot-out 167.97 APE67-dihe-in -65.55, -27.52 -54.27, -41.89 APE12-dist-in 12.9325 APE11-dist-in 12.5982 APE10-dist-in 6.8078 APE9-dist-in 3.452 K965R TPO893 TPO893 XRAY 3.25 0.198 0.217 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8but Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 6CKXA Q9NYV4 722 1024 1490.0 8M1:1102 Type1 Inactive DFGin 7.032 14.821 BLAminus -136.28, -177.03 50.17, 81.66 -95.72, 28.97 286.79, 82.51 -69.6, -12.29 in-in in 8.9773 Saltbr-in 3.0837 HRD-in -75.68, -51.15 65.95, 11.38 in-in-out SNCiio in-out ActLoopNT-in 3.1223 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -144.15, 162.82 APE9-dihe-na 64.99, 132.37 APE8-dihe-in -65.8, 148.5 APE8-rot-out 58.87 APE67-dihe-in -65.02, -18.1 -33.35, -57.74 APE12-dist-in 13.1407 APE11-dist-in 11.0604 APE10-dist-in 6.8749 APE9-dist-in 3.4947 None TPO893 TPO893 XRAY 2.8 0.21 0.251 A 351.0 293.0 10 29 29 0 [[727, 1020]] 1.0 6ckx Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 6CKXC Q9NYV4 722 1024 1490.0 8M1:1102 Type1 Inactive DFGin 6.9855 14.7579 BLAminus -135.84, -177.96 50.19, 82.31 -95.98, 27.29 286.66, 82.56 -71.33, -10.74 in-in in 8.9818 Saltbr-in 3.064 HRD-in -76.42, -51.05 66.38, 11.81 in-in-out SNCiio in-out ActLoopNT-in 3.093 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -143.35, 161.59 APE9-dihe-na 66.9, 134.68 APE8-dihe-in -66.86, 147.72 APE8-rot-out 60.13 APE67-dihe-in -63.67, -17.47 -33.52, -58.49 APE12-dist-in 13.1506 APE11-dist-in 11.1875 APE10-dist-in 6.9301 APE9-dist-in 3.5241 None TPO893 TPO893 XRAY 2.8 0.21 0.251 C 351.0 293.0 10 29 29 0 [[727, 1020]] 1.0 6ckx Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 7NXKC Q9NYV4 717 1040 1490.0 UUB:2000 Type1 Inactive DFGin 7.2388 15.3617 BLAminus -141.93, -168.1 55.29, 66.48 -89.47, 23.2 285.63, 87.42 -65.95, -22.63 in-none in 9.1644 Saltbr-none 999.0 HRD-in -59.09, -64.11 84.9, -5.29 none-in-out SNCnio in-out ActLoopNT-in 3.0998 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.36, -24.98 APE9-dihe-na -111.23, 152.03 APE8-dihe-in -58.18, 144.58 APE8-rot-out 41.59 APE67-dihe-in -69.39, -10.03 -63.92, -28.51 APE12-dist-in 13.0199 APE11-dist-in 11.29 APE10-dist-in 6.4678 APE9-dist-in 3.4673 None TPO893 TPO893 XRAY 3.0 0.222 0.264 C 351.0 314.0 10 29 29 0 [[727, 1020]] 1.0 7nxk Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUGH Q9NYV4 715 1039 1490.0 No_ligand No_ligand Inactive DFGin 6.8959 15.5984 None -126.85, -81.65 -69.29, 99.31 -95.06, 17.81 283.55, 80.77 -62.15, -37.73 in-out in 8.4976 Saltbr-out 4.2388 HRD-in -64.31, -53.09 70.58, 6.39 out-in-out SNCoio in-out ActLoopNT-in 3.0823 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -77.05, -49.38 APE9-dihe-na -69.37, 152.54 APE8-dihe-in -59.34, 145.1 APE8-rot-out 62.3 APE67-dihe-in -62.01, -33.03 -53.97, -44.11 APE12-dist-in 12.9733 APE11-dist-in 12.4826 APE10-dist-in 6.5883 APE9-dist-in 3.6522 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 H 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bug Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU1B Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 6.8884 15.2984 None -128.47, -62.59 -80.73, 98.22 -97.65, 30.1 286.08, 74.34 -69.36, -27.39 in-in in 7.8207 Saltbr-in 3.2637 HRD-in -79.79, -51.42 72.8, -1.21 in-in-out SNCiio in-out ActLoopNT-in 2.7133 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.4, -55.58 APE9-dihe-na -85.22, 150.62 APE8-dihe-in -62.26, 144.21 APE8-rot-out 179.44 APE67-dihe-in -65.72, -30.15 -51.5, -38.4 APE12-dist-in 13.2818 APE11-dist-in 11.6162 APE10-dist-in 6.9008 APE9-dist-in 3.7142 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 B 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu1 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU1H Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 6.9866 15.4035 None -124.14, -66.45 -82.78, 98.54 -96.09, 28.76 284.79, 71.99 -70.28, -26.46 in-in in 7.8662 Saltbr-in 3.166 HRD-in -79.63, -53.16 73.52, -1.03 in-in-out SNCiio in-out ActLoopNT-in 2.7593 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.57, -50.83 APE9-dihe-na -86.52, 154.66 APE8-dihe-in -59.58, 143.86 APE8-rot-out 8.75 APE67-dihe-in -65.52, -30.46 -51.58, -39.94 APE12-dist-in 13.8095 APE11-dist-in 12.2137 APE10-dist-in 7.2362 APE9-dist-in 3.5954 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu1 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU2B Q9NYV4 715 1041 1490.0 RVQ:61101 Type1 Inactive DFGin 6.9805 15.316 None -126.39, -67.8 -89.47, 99.61 -92.58, 32.18 287.62, 78.29 -74.11, -9.98 in-in in 7.7621 Saltbr-in 3.4941 HRD-in -72.7, -49.44 72.16, 4.81 in-in-in SNCiii in-in ActLoopNT-in 2.9597 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.12, -45.69 APE9-dihe-na -96.32, 148.59 APE8-dihe-in -57.39, 143.59 APE8-rot-in 288.86 APE67-dihe-in -63.0, -36.42 -47.95, -40.21 APE12-dist-in 13.5359 APE11-dist-in 11.7305 APE10-dist-in 7.073 APE9-dist-in 3.726 K965R TPO893 TPO893 XRAY 3.13 0.193 0.217 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bu2 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU3B Q9NYV4 715 1040 1490.0 RSI:1101 Type1 Inactive DFGin 6.8486 15.3593 None -135.97, -63.81 -78.62, 93.23 -91.89, 22.93 285.59, 76.13 -60.89, -23.4 in-in in 7.9934 Saltbr-in 2.817 HRD-in -67.65, -55.64 77.98, -1.58 in-in-in SNCiii in-in ActLoopNT-in 3.0522 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.96, -44.7 APE9-dihe-na -101.31, 148.75 APE8-dihe-in -59.73, 145.03 APE8-rot-in 305.94 APE67-dihe-in -60.6, -36.33 -55.27, -39.92 APE12-dist-in 13.312 APE11-dist-in 11.5417 APE10-dist-in 7.0493 APE9-dist-in 3.3827 K965R TPO893 TPO893 XRAY 3.42 0.187 0.213 B 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8bu3 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU3H Q9NYV4 715 1044 1490.0 RSI:1101 Type1 Inactive DFGin 6.9756 15.4654 None -130.35, -57.76 -91.85, 92.73 -91.21, 19.54 285.51, 78.88 -63.9, -27.23 in-in in 8.132 Saltbr-in 3.2809 HRD-in -66.37, -58.1 77.05, -1.53 in-in-out SNCiio in-out ActLoopNT-in 3.0176 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.62, -44.32 APE9-dihe-na -91.3, 148.63 APE8-dihe-in -63.87, 147.34 APE8-rot-out 172.41 APE67-dihe-in -60.12, -36.58 -54.35, -41.92 APE12-dist-in 13.7142 APE11-dist-in 11.8523 APE10-dist-in 6.8179 APE9-dist-in 3.3613 K965R TPO893 TPO893 XRAY 3.42 0.187 0.213 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu3 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU5E Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 6.9424 15.1221 None -123.64, -63.66 -81.97, -51.09 56.28, 22.54 292.49, 98.9 -91.33, -28.22 in-out in 8.3713 Saltbr-out 3.6222 HRD-in -72.77, -54.57 74.45, -4.91 out-in-out SNCoio in-out ActLoopNT-in 2.7589 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -134.16, -27.33 APE9-dihe-na -98.05, 157.33 APE8-dihe-in -51.55, 136.25 APE8-rot-in 308.17 APE67-dihe-in -63.16, -26.85 -49.17, -41.17 APE12-dist-out 14.1246 APE11-dist-in 12.1682 APE10-dist-in 7.2856 APE9-dist-in 3.7263 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 E 344.0 331.0 0 29 29 0 [[727, 1020]] 1.0 8bu5 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU6B Q9NYV4 715 1039 1490.0 RQE:61101 Type1 Inactive DFGin 6.9772 15.0095 None -127.82, -64.26 -87.77, 91.87 -89.24, 20.45 288.89, 72.08 -65.57, -40.39 in-in in 8.424 Saltbr-in 3.4813 HRD-in -70.61, -57.84 77.83, -2.42 in-in-out SNCiio in-out ActLoopNT-in 3.1224 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.14, -54.56 APE9-dihe-na -81.61, 149.37 APE8-dihe-in -53.79, 145.32 APE8-rot-out 74.18 APE67-dihe-in -56.42, -37.71 -55.03, -39.62 APE12-dist-in 13.9274 APE11-dist-in 11.7836 APE10-dist-in 6.969 APE9-dist-in 3.408 K965R TPO893 TPO893 XRAY 3.45 0.219 0.249 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu6 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU6H Q9NYV4 715 1038 1490.0 RQE:61101 Type1 Inactive DFGin 6.8592 15.2278 None -123.73, -80.29 -80.87, 99.66 -87.02, 20.65 285.61, 58.62 -65.39, -44.16 in-out in 8.4216 Saltbr-out 5.0958 HRD-in -73.68, -57.19 78.4, -0.7 out-in-out SNCoio in-out ActLoopNT-in 3.0861 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.54, -53.3 APE9-dihe-na -74.55, 153.16 APE8-dihe-in -53.11, 139.67 APE8-rot-out 166.86 APE67-dihe-in -53.97, -35.01 -57.57, -41.34 APE12-dist-in 13.1365 APE11-dist-in 12.4283 APE10-dist-in 7.0199 APE9-dist-in 3.4215 K965R TPO893 TPO893 XRAY 3.45 0.219 0.249 H 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bu6 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BU9B Q9NYV4 715 1039 1490.0 RRC:61101 Type1 Inactive DFGin 6.8954 15.5504 None -126.5, -98.68 -52.95, 118.93 -112.03, 20.69 280.85, 78.53 -65.13, -14.55 in-in in 8.0334 Saltbr-in 3.4619 HRD-in -71.08, -52.06 74.5, 2.49 in-in-out SNCiio in-out ActLoopNT-in 3.0383 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.03, -51.01 APE9-dihe-na -76.4, 148.49 APE8-dihe-in -61.77, 145.89 APE8-rot-out 190.86 APE67-dihe-in -62.1, -33.32 -50.51, -38.53 APE12-dist-in 13.2624 APE11-dist-in 11.7849 APE10-dist-in 6.4997 APE9-dist-in 3.5775 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUBH Q9NYV4 715 1044 1490.0 RNU:61102 Type1 Inactive DFGin 7.2638 15.677 None -126.03, -25.89 -87.61, 72.88 -91.51, 12.82 280.63, 73.67 -60.75, -39.82 in-in in 8.4819 Saltbr-in 3.5525 HRD-out -79.78, 93.25 -67.97, -38.17 in-out-out SNCioo out-out ActLoopNT-out 3.72 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iiii APE10-dihe-na -109.56, -9.94 APE9-dihe-na -106.55, 22.31 APE8-dihe-out 64.82, 23.4 APE8-rot-out 71.99 APE67-dihe-out -104.68, -30.69 71.46, -1.72 APE12-dist-in 12.7113 APE11-dist-in 12.093 APE10-dist-in 6.8605 APE9-dist-in 4.5978 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bub Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUCH Q9NYV4 715 1044 1490.0 RKO:61101 Type1 Inactive DFGin 6.938 15.2425 None -126.85, -64.01 -88.43, 98.06 -96.23, 24.88 287.21, 69.27 -75.34, -9.66 in-in in 7.9464 Saltbr-in 3.3005 HRD-in -84.47, -51.91 75.61, -7.74 in-in-in SNCiii in-in ActLoopNT-in 2.9789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.44, -52.72 APE9-dihe-na -81.82, 150.47 APE8-dihe-in -58.85, 136.79 APE8-rot-in 300.83 APE67-dihe-in -60.33, -38.14 -49.32, -40.23 APE12-dist-in 13.7625 APE11-dist-in 11.7819 APE10-dist-in 6.9727 APE9-dist-in 3.2597 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8buc Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUEB Q9NYV4 715 1043 1490.0 RVU:61101 Type1 Inactive DFGin 6.8762 15.6 None -134.01, -59.19 -81.95, 94.22 -92.57, 38.59 286.02, 76.0 -80.72, -24.77 in-in in 7.932 Saltbr-in 2.9874 HRD-in -72.56, -56.91 77.87, 2.52 in-in-out SNCiio in-out ActLoopNT-in 2.9042 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.91, -27.24 APE9-dihe-na -111.61, 155.18 APE8-dihe-in -59.11, 144.49 APE8-rot-out 174.63 APE67-dihe-in -64.14, -33.78 -56.66, -36.69 APE12-dist-in 13.2286 APE11-dist-in 11.5753 APE10-dist-in 6.8399 APE9-dist-in 3.7328 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 B 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bue Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUFB Q9NYV4 715 1033 1490.0 RW6:61101 Type1 Inactive DFGin 6.9051 15.6357 None -129.93, -62.21 -79.23, 97.53 -95.7, 37.47 286.05, 76.01 -76.9, -21.74 in-in in 8.1053 Saltbr-in 3.1532 HRD-in -72.11, -52.31 75.51, 2.58 in-in-out SNCiio in-out ActLoopNT-in 2.8864 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.68, -63.24 APE9-dihe-na -77.98, 146.57 APE8-dihe-in -61.93, 149.44 APE8-rot-out 186.78 APE67-dihe-in -61.63, -31.53 -53.67, -39.8 APE12-dist-in 13.1702 APE11-dist-in 10.9939 APE10-dist-in 6.5903 APE9-dist-in 3.5503 K965R TPO893 TPO893 XRAY 3.3 0.185 0.22 B 344.0 319.0 0 29 29 0 [[727, 1020]] 1.0 8buf Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUFH Q9NYV4 715 1032 1490.0 RW6:61101 Type1 Inactive DFGin 7.1171 15.5053 None -129.62, -58.72 -84.56, 91.07 -93.16, 33.34 286.36, 76.3 -77.96, -20.03 in-out in 8.1468 Saltbr-out 3.7328 HRD-in -74.59, -54.27 72.47, 1.47 out-in-in SNCoii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.36, -62.78 APE9-dihe-na -81.18, 153.72 APE8-dihe-in -60.4, 148.16 APE8-rot-in 306.45 APE67-dihe-in -63.34, -32.17 -56.22, -41.31 APE12-dist-in 13.7169 APE11-dist-in 11.792 APE10-dist-in 7.061 APE9-dist-in 3.3785 K965R TPO893 TPO893 XRAY 3.3 0.185 0.22 H 344.0 318.0 0 29 29 0 [[727, 1020]] 1.0 8buf Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUGB Q9NYV4 715 1041 1490.0 RPW:61101 Type1 Inactive DFGin 6.885 15.532 None -132.35, -51.84 -89.28, 88.82 -91.59, 19.28 282.49, 80.64 -62.07, -38.03 in-in in 8.0337 Saltbr-in 2.912 HRD-in -62.84, -54.31 70.37, 7.41 in-in-out SNCiio in-out ActLoopNT-in 3.0011 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -68.25, -47.63 APE9-dihe-na -75.15, 151.02 APE8-dihe-in -63.11, 148.71 APE8-rot-out 182.54 APE67-dihe-in -62.59, -33.17 -53.62, -43.42 APE12-dist-in 12.5031 APE11-dist-in 11.8127 APE10-dist-in 6.379 APE9-dist-in 3.619 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bug Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUHB Q9NYV4 715 1039 1490.0 RR9:61101 Type1 Inactive DFGin 7.1787 15.539 None -138.13, -51.2 -84.38, 89.05 -94.33, 22.38 291.72, 70.83 -65.07, -27.18 in-in in 8.1562 Saltbr-in 3.1703 HRD-in -65.3, -52.38 69.31, 6.78 in-in-out SNCiio in-out ActLoopNT-in 2.9184 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -73.08, -42.42 APE9-dihe-na -75.03, 155.7 APE8-dihe-in -68.77, 151.86 APE8-rot-out 184.25 APE67-dihe-in -61.51, -37.69 -56.24, -40.88 APE12-dist-in 12.2995 APE11-dist-in 11.9854 APE10-dist-in 6.1967 APE9-dist-in 3.6729 K965R TPO893 TPO893 XRAY 3.79 0.189 0.232 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8buh Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUHH Q9NYV4 715 1033 1490.0 RR9:61101 Type1 Inactive DFGin 6.8874 15.2204 None -138.17, -50.63 -86.02, 83.59 -88.15, 19.63 292.55, 71.89 -63.06, -22.61 in-in in 8.184 Saltbr-in 2.9431 HRD-in -66.24, -47.16 69.47, -1.27 in-in-out SNCiio in-out ActLoopNT-in 3.0446 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -73.8, -40.23 APE9-dihe-na -75.94, 158.01 APE8-dihe-in -67.45, 146.95 APE8-rot-out 179.42 APE67-dihe-in -59.63, -39.48 -58.91, -41.72 APE12-dist-in 13.2298 APE11-dist-in 12.4677 APE10-dist-in 6.767 APE9-dist-in 3.3762 K965R TPO893 TPO893 XRAY 3.79 0.189 0.232 H 344.0 319.0 0 29 29 0 [[727, 1020]] 1.0 8buh Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUJB Q9NYV4 715 1041 1490.0 RUW:1101 Type1 Inactive DFGin 6.983 15.1999 None -129.99, -57.9 -94.94, 86.34 -84.73, 29.33 287.08, 75.1 -66.06, -25.85 in-in in 7.8642 Saltbr-in 2.9459 HRD-in -63.86, -54.33 75.41, -2.11 in-in-out SNCiio in-out ActLoopNT-in 3.0628 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -117.09, -50.74 APE9-dihe-na -90.83, 154.53 APE8-dihe-in -64.5, 148.14 APE8-rot-out 189.98 APE67-dihe-in -60.8, -34.01 -57.18, -38.53 APE12-dist-in 13.2622 APE11-dist-in 11.4247 APE10-dist-in 7.1058 APE9-dist-in 3.5216 K965R TPO893 TPO893 XRAY 3.62 0.164 0.206 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8buj Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUJH Q9NYV4 715 1043 1490.0 RUW:1101 Type1 Inactive DFGin 6.896 15.0772 None -125.46, -61.45 -96.84, 87.36 -85.01, 26.05 287.54, 74.01 -66.36, -25.41 in-in in 7.8133 Saltbr-in 3.0099 HRD-in -63.78, -55.47 74.76, -1.95 in-in-in SNCiii in-in ActLoopNT-in 2.9668 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.8, -48.82 APE9-dihe-na -90.4, 155.44 APE8-dihe-in -63.14, 147.75 APE8-rot-in 306.89 APE67-dihe-in -59.19, -33.71 -59.17, -40.93 APE12-dist-in 13.546 APE11-dist-in 11.4373 APE10-dist-in 6.9005 APE9-dist-in 3.4536 K965R TPO893 TPO893 XRAY 3.62 0.164 0.206 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8buj Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUKB Q9NYV4 715 1040 1490.0 RWE:61101 Type1 Inactive DFGin 6.8676 15.185 None -136.79, -63.9 -86.16, 95.92 -96.18, 34.75 292.05, 70.82 -73.05, -21.93 in-in in 7.9967 Saltbr-in 2.8964 HRD-in -70.18, -56.12 75.44, 6.36 in-in-in SNCiii in-in ActLoopNT-in 2.9507 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.1, -51.8 APE9-dihe-na -97.16, 156.72 APE8-dihe-in -60.0, 144.72 APE8-rot-in 296.0 APE67-dihe-in -62.91, -30.64 -55.4, -37.75 APE12-dist-in 13.3442 APE11-dist-in 11.4945 APE10-dist-in 7.2213 APE9-dist-in 3.6338 K965R TPO893 TPO893 XRAY 3.41 0.186 0.21 B 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8buk Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUKH Q9NYV4 715 1044 1490.0 RWE:61101 Type1 Inactive DFGin 6.839 15.2471 None -132.41, -70.3 -85.48, 98.43 -94.85, 32.62 289.18, 70.32 -75.66, -23.83 in-in in 8.0838 Saltbr-in 3.0875 HRD-in -67.86, -57.14 74.14, 6.98 in-in-out SNCiio in-out ActLoopNT-in 2.8859 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -102.71, -45.22 APE9-dihe-na -97.3, 156.39 APE8-dihe-in -62.45, 146.81 APE8-rot-out 169.98 APE67-dihe-in -63.55, -31.48 -56.16, -39.65 APE12-dist-in 13.6893 APE11-dist-in 11.7966 APE10-dist-in 7.1304 APE9-dist-in 3.7281 K965R TPO893 TPO893 XRAY 3.41 0.186 0.21 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8buk Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BULB Q9NYV4 715 1039 1490.0 RSU:1101 Type1 Inactive DFGin 7.0478 15.5723 None -134.15, -61.62 -82.15, 93.36 -91.03, 19.31 284.15, 82.25 -57.36, -30.14 in-in in 7.9382 Saltbr-in 2.9293 HRD-in -70.64, -53.34 75.97, 4.36 in-in-in SNCiii in-in ActLoopNT-in 3.1167 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.1, -23.33 APE9-dihe-na -106.91, 152.49 APE8-dihe-in -59.59, 141.04 APE8-rot-in 301.22 APE67-dihe-in -61.09, -37.16 -52.97, -42.84 APE12-dist-in 13.2976 APE11-dist-in 11.6069 APE10-dist-in 6.723 APE9-dist-in 3.6083 None TPO893 TPO893 XRAY 3.4 0.179 0.215 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bul Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUMB Q9NYV4 715 1040 1490.0 T6X:1101 Type1 Inactive DFGin 6.8637 15.6654 None -134.73, -83.5 -67.29, 93.27 -90.11, 26.53 284.48, 75.06 -65.26, -28.59 in-in in 7.994 Saltbr-in 3.4847 HRD-in -65.89, -56.24 77.66, 6.87 in-in-in SNCiii in-in ActLoopNT-in 3.1268 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.13, -38.62 APE9-dihe-na -95.11, 154.79 APE8-dihe-in -60.97, 148.11 APE8-rot-in 309.8 APE67-dihe-in -61.69, -36.7 -58.55, -38.83 APE12-dist-in 13.4563 APE11-dist-in 11.5984 APE10-dist-in 6.6698 APE9-dist-in 3.6672 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 B 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8bum Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUMH Q9NYV4 715 1039 1490.0 T6X:1101 Type1 Inactive DFGin 7.0235 15.4568 None -135.37, -57.05 -84.79, 89.46 -91.01, 22.09 287.95, 72.46 -66.77, -30.21 in-out in 8.0681 Saltbr-out 4.1308 HRD-in -66.21, -56.87 75.95, 5.67 out-in-in SNCoii in-in ActLoopNT-in 2.9548 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.45, -40.59 APE9-dihe-na -95.46, 155.5 APE8-dihe-in -61.11, 150.0 APE8-rot-in 312.75 APE67-dihe-in -61.06, -36.71 -56.48, -41.62 APE12-dist-in 13.6249 APE11-dist-in 11.7363 APE10-dist-in 7.1678 APE9-dist-in 3.5793 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 H 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bum Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUOH Q9NYV4 715 1044 1490.0 RLC:1101 Type1 Inactive DFGin 6.9531 15.2665 None -133.0, -52.84 -89.06, 92.6 -92.03, 19.54 286.01, 76.31 -65.14, -29.67 in-in in 8.1958 Saltbr-in 3.2893 HRD-in -68.8, -55.72 77.31, -13.16 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.5, -30.39 APE9-dihe-na -96.1, 151.94 APE8-dihe-in -61.51, 140.45 APE8-rot-in 333.9 APE67-dihe-in -58.03, -34.02 -53.9, -41.38 APE12-dist-in 13.5492 APE11-dist-in 11.7907 APE10-dist-in 6.7655 APE9-dist-in 3.3578 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8buo Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUQH Q9NYV4 715 1035 1490.0 RQ9:61101 Type1 Inactive DFGin 6.8471 15.4131 None -139.0, -68.9 -74.65, 86.14 -87.77, 25.62 285.6, 75.05 -68.98, -27.88 in-in in 8.1409 Saltbr-in 3.3418 HRD-in -71.56, -55.82 75.32, -0.25 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.77, -46.85 APE9-dihe-na -88.37, 155.15 APE8-dihe-in -63.62, 147.91 APE8-rot-out 74.55 APE67-dihe-in -59.91, -28.34 -56.29, -43.5 APE12-dist-in 13.7059 APE11-dist-in 11.9801 APE10-dist-in 7.0593 APE9-dist-in 3.5434 K965R TPO893 TPO893 XRAY 3.2 0.196 0.216 H 344.0 321.0 0 29 29 0 [[727, 1020]] 1.0 8buq Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BURH Q9NYV4 715 1039 1490.0 RQU:61101 Type1 Inactive DFGin 6.7739 15.4438 None -128.98, -68.65 -83.3, 94.14 -94.27, 19.71 289.32, 85.87 -66.64, -31.92 in-in in 8.1448 Saltbr-in 2.8791 HRD-in -62.95, -51.76 69.51, 6.54 in-in-out SNCiio in-out ActLoopNT-in 3.108 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -119.35, -54.64 APE9-dihe-na -87.35, 151.65 APE8-dihe-in -60.57, 144.24 APE8-rot-out 76.95 APE67-dihe-in -62.32, -33.37 -50.2, -40.95 APE12-dist-in 13.7432 APE11-dist-in 11.6616 APE10-dist-in 7.0858 APE9-dist-in 3.6711 K965R TPO893 TPO893 XRAY 3.64 0.192 0.234 H 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bur Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 8BUSE Q9NYV4 715 1043 1490.0 RMX:1101 Type1 Inactive DFGin 6.7257 15.8693 None -132.84, -50.43 -84.41, 82.25 -87.45, 22.35 281.7, 77.83 -63.73, -33.79 in-in in 8.1583 Saltbr-in 3.2823 HRD-in -70.71, -48.94 71.36, 12.53 in-in-out SNCiio in-out ActLoopNT-in 2.9956 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -96.11, -47.21 APE9-dihe-na -97.32, 150.19 APE8-dihe-in -67.32, 151.1 APE8-rot-out 195.8 APE67-dihe-in -58.67, -27.66 -56.54, -42.34 APE12-dist-in 13.2846 APE11-dist-in 11.3926 APE10-dist-in 7.3398 APE9-dist-in 3.4564 K965R TPO893 TPO893 XRAY 3.26 0.209 0.228 E 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bus Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12 CDK12_HUMAN 9FMRB Q9NYV4 714 1047 1490.0 RMF:61101 Type1 Inactive DFGin 7.1242 15.0312 None -111.49, -74.26 -77.99, -72.15 68.85, 12.84 296.16, 89.8 -66.22, -36.51 in-out in 8.3316 Saltbr-out 4.4499 HRD-in -70.8, -35.56 62.81, 1.22 out-in-in SNCoii in-in ActLoopNT-in 3.0722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.03, -25.75 APE9-dihe-na -103.56, 146.88 APE8-dihe-in -51.72, 138.27 APE8-rot-in 305.58 APE67-dihe-in -69.51, -21.36 -53.61, -35.19 APE12-dist-in 13.9874 APE11-dist-in 12.2701 APE10-dist-in 7.331 APE9-dist-in 3.8645 None TPO893 TPO893 XRAY 3.9 0.209 0.25 B 351.0 334.0 0 29 29 0 [[727, 1020]] 1.0 9fmr Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

CMGC_CDK12 (Cyclin-dependent kinase 12)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name