CMGC_CDK12 (Cyclin-dependent kinase 12)

Total number of chains: 109
Active chains: 10
Family: CMGC
Uniprot: CDK12_HUMAN
Kinase Domain Residues: 727 - 1020
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 53 48.6% AF-Q9NYV4-K1A
DFGin None 30 27.5% 8BU1B
DFGin ABAminus 26 23.9% 8BUNB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q9NYV4-K1A 719 1028 1490.0 No_ligand No_ligand Active DFGin 6.742 15.021 BLAminus -135.31, 176.11 57.83, 65.7 -78.9, 19.02 283.91, 75.49 -59.53, -34.42 in-in in 8.848 Saltbr-in 2.872 HRD-in -74.38, -50.97 65.06, 11.96 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.35, 171.85 APE9-dihe-na 62.69, 132.06 APE8-dihe-in -56.47, 137.03 APE8-rot-in 300.21 APE67-dihe-in -68.24, -22.81 -49.07, -40.83 APE12-dist-in 13.067 APE11-dist-in 11.195 APE10-dist-in 6.634 APE9-dist-in 3.345 None None None AF2 -1.0 1.0 1.0 A 310 310 0 0 0 0 [[727, 1020]] 1.0 AF-Q9NYV4-K1 CMGC_CDK12_HUMAN CMGC 1.8e-84 289.4 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
AF-Q9NYV4-K3A 719 1028 1490.0 No_ligand No_ligand Active DFGin 6.943 15.648 BLAminus -131.2, -179.25 62.41, 52.03 -71.34, 9.91 284.98, 77.79 -61.92, -24.64 in-in in 8.449 Saltbr-in 3.026 HRD-in -78.33, -50.25 65.94, 8.6 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.81, 169.8 APE9-dihe-na 61.73, 134.8 APE8-dihe-in -58.63, 136.64 APE8-rot-in 295.26 APE67-dihe-in -64.98, -27.17 -49.82, -42.02 APE12-dist-in 13.481 APE11-dist-in 11.609 APE10-dist-in 7.174 APE9-dist-in 3.21 None None None AF2 -1.0 1.0 1.0 A 310 310 0 0 0 0 [[727, 1020]] 1.0 AF-Q9NYV4-K3 CMGC_CDK12_HUMAN CMGC 1.8e-84 289.4 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU7B 715 1043 1490.0 No_ligand No_ligand Active DFGin 7.077 15.544 BLAminus -153.2, -179.33 57.0, 56.86 -76.66, 35.76 288.9, 72.8 -62.53, -36.58 in-in in 7.944 Saltbr-in 2.97 HRD-in -65.11, -49.8 70.58, 2.94 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.3, -42.09 APE9-dihe-na -92.76, 146.08 APE8-dihe-in -61.7, 141.25 APE8-rot-in 286.85 APE67-dihe-in -64.16, -31.94 -48.15, -39.73 APE12-dist-in 12.796 APE11-dist-in 11.304 APE10-dist-in 6.44 APE9-dist-in 3.723 K965R TPO893 TPO893 XRAY 3.245 0.193 0.219 B 344 329 0 0 0 0 [[727, 1020]] 1.0 8bu7 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU7H 715 1043 1490.0 No_ligand No_ligand Active DFGin 6.925 15.216 BLAminus -150.49, -178.12 60.69, 55.85 -80.72, 28.91 286.49, 71.19 -68.37, -37.18 in-in in 7.997 Saltbr-in 3.127 HRD-in -67.99, -49.39 67.61, 1.86 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.1, -50.99 APE9-dihe-na -89.61, 147.06 APE8-dihe-in -59.45, 144.95 APE8-rot-in 311.35 APE67-dihe-in -64.87, -31.1 -48.4, -40.63 APE12-dist-in 13.821 APE11-dist-in 11.638 APE10-dist-in 7.151 APE9-dist-in 3.568 K965R TPO893 TPO893 XRAY 3.245 0.193 0.219 H 344 329 0 0 0 0 [[727, 1020]] 1.0 8bu7 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
6TD3E 715 1047 1490.0 RC8:1101 Type1 Active DFGin 7.044 15.193 BLAminus -147.32, 173.39 63.76, 65.42 -84.24, 25.56 288.49, 76.82 -64.44, -36.48 in-in in 7.974 Saltbr-in 3.167 HRD-in -75.19, -47.55 67.28, 2.07 in-in-in SNCiii in-in ActLoopNT-in 2.953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -75.91, -39.12 APE9-dihe-na -86.17, 150.74 APE8-dihe-in -63.73, 141.42 APE8-rot-in 305.37 APE67-dihe-in -59.47, -32.88 -40.08, -54.92 APE12-dist-in 13.176 APE11-dist-in 11.902 APE10-dist-in 6.855 APE9-dist-in 3.435 K965R TPO893 TPO893 XRAY 3.46 0.195 0.22 E 344 333 0 0 0 0 [[727, 1020]] 1.0 6td3 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU3E 715 1039 1490.0 RSI:1101 Type1 Active DFGin 7.141 15.534 BLAminus -142.27, 178.66 43.04, 82.11 -92.94, 21.36 280.44, 78.98 -62.21, -28.8 in-in in 8.118 Saltbr-in 3.049 HRD-in -67.4, -56.47 76.99, -0.73 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.29, 7.21 APE9-dihe-na -139.88, 150.07 APE8-dihe-in -59.05, 143.88 APE8-rot-in 303.03 APE67-dihe-in -61.38, -34.53 -56.72, -42.72 APE12-dist-in 13.107 APE11-dist-in 12.76 APE10-dist-in 7.175 APE9-dist-in 3.446 K965R TPO893 TPO893 XRAY 3.42 0.187 0.213 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bu3 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BULE 715 1038 1490.0 RSU:1101 Type1 Active DFGin 7.269 15.574 BLAminus -142.23, 173.11 51.26, 74.93 -90.42, 13.84 281.63, 81.18 -57.04, -28.57 in-in in 8.073 Saltbr-in 3.068 HRD-in -70.66, -53.79 75.17, 4.92 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.18, -18.48 APE9-dihe-na -95.24, 149.84 APE8-dihe-in -59.92, 143.14 APE8-rot-in 301.12 APE67-dihe-in -61.61, -35.96 -53.3, -43.95 APE12-dist-in 12.727 APE11-dist-in 12.53 APE10-dist-in 6.687 APE9-dist-in 3.385 None TPO893 TPO893 XRAY 3.4 0.179 0.215 E 344 324 0 0 0 0 [[727, 1020]] 1.0 8bul CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUME 715 1039 1490.0 T6X:1101 Type1 Active DFGin 7.174 15.484 BLAminus -146.26, -169.41 35.67, 76.14 -91.08, 23.16 287.18, 101.24 -64.43, -27.28 in-in in 8.379 Saltbr-in 3.393 HRD-in -65.58, -57.98 78.09, 6.9 in-in-in SNCiii in-in ActLoopNT-in 3.007 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.86, -32.86 APE9-dihe-na -90.18, 155.36 APE8-dihe-in -60.4, 149.13 APE8-rot-in 310.02 APE67-dihe-in -62.09, -34.98 -57.41, -41.5 APE12-dist-in 12.684 APE11-dist-in 12.102 APE10-dist-in 6.747 APE9-dist-in 3.38 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bum CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUPH 715 1028 1490.0 RWN:61101 Type1 Active DFGin 7.109 15.406 BLAminus -147.42, -178.11 55.21, 58.82 -78.24, 30.65 278.56, 80.87 -74.41, -18.78 in-in in 8.092 Saltbr-in 3.315 HRD-in -72.38, -49.1 69.31, -11.39 in-in-in SNCiii in-in ActLoopNT-in 3.034 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.08, -16.8 APE9-dihe-na -129.39, 159.74 APE8-dihe-in -65.11, 144.15 APE8-rot-in 304.17 APE67-dihe-in -60.23, -34.65 -53.66, -41.25 APE12-dist-in 13.306 APE11-dist-in 10.977 APE10-dist-in 7.068 APE9-dist-in 3.502 K965R TPO893 TPO893 XRAY 3.41 0.201 0.223 H 344 314 0 0 0 0 [[727, 1020]] 1.0 8bup CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8P81A 716 1035 1490.0 RMF:1101 Type1 Active DFGin 7.095 14.446 BLAminus -134.83, -178.64 59.2, 72.19 -89.53, 34.88 291.56, 80.44 -67.97, -22.73 in-in in 8.359 Saltbr-in 3.057 HRD-in -81.5, -42.97 59.01, 18.94 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.63, 165.61 APE9-dihe-na 67.08, 139.25 APE8-dihe-in -61.99, 152.33 APE8-rot-in 316.49 APE67-dihe-in -68.12, -20.85 -57.98, -41.98 APE12-dist-in 12.679 APE11-dist-in 10.561 APE10-dist-in 6.52 APE9-dist-in 3.212 None TPO893 TPO893 XRAY 2.68 0.212 0.255 A 351 320 0 0 0 0 [[727, 1020]] 1.0 8p81 CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU2H 715 1043 1490.0 RVQ:61101 Type1 Inactive DFGin 7.124 15.366 ABAminus -126.78, -38.9 -105.5, 92.35 -91.27, 30.22 285.75, 68.07 -78.32, -11.53 in-in in 7.785 Saltbr-in 3.316 HRD-in -76.93, -54.56 71.73, 6.27 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.54, -42.84 APE9-dihe-na -100.7, 153.79 APE8-dihe-in -58.19, 144.22 APE8-rot-in 306.05 APE67-dihe-in -62.43, -37.08 -51.71, -42.2 APE12-dist-in 13.851 APE11-dist-in 11.936 APE10-dist-in 7.208 APE9-dist-in 3.638 K965R TPO893 TPO893 XRAY 3.13 0.193 0.217 H 344 329 0 0 0 0 [[727, 1020]] 1.0 8bu2 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU4B 715 1043 1490.0 RQL:61101 Type1 Inactive DFGin 6.85 15.448 ABAminus -129.55, -62.28 -85.09, 103.01 -99.2, 24.51 288.36, 76.72 -66.96, -36.21 in-in in 8.357 Saltbr-in 2.975 HRD-in -68.4, -61.77 77.35, 4.99 in-in-out SNCiio in-out ActLoopNT-in 2.992 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.64, -39.36 APE9-dihe-na -92.3, 149.92 APE8-dihe-in -61.52, 149.36 APE8-rot-out 186.04 APE67-dihe-in -64.54, -31.54 -56.18, -38.32 APE12-dist-in 13.385 APE11-dist-in 11.507 APE10-dist-in 6.611 APE9-dist-in 3.458 K965R TPO893 TPO893 XRAY 3.09 0.205 0.223 B 344 329 0 0 0 0 [[727, 1020]] 1.0 8bu4 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU4H 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 7.047 15.528 ABAminus -118.75, -57.9 -97.23, 97.83 -98.97, 29.55 288.47, 78.73 -75.71, -15.5 in-out in 8.287 Saltbr-out 3.906 HRD-in -79.59, -55.06 74.66, 4.8 out-in-out SNCoio in-out ActLoopNT-in 2.879 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -121.0, -34.01 APE9-dihe-na -98.0, 156.31 APE8-dihe-in -61.54, 149.21 APE8-rot-out 67.45 APE67-dihe-in -64.95, -40.0 -58.15, -33.89 APE12-dist-in 13.822 APE11-dist-in 12.046 APE10-dist-in 7.165 APE9-dist-in 3.551 K965R TPO893 TPO893 XRAY 3.09 0.205 0.223 H 344 330 0 0 0 0 [[727, 1020]] 1.0 8bu4 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU5B 713 1044 1490.0 RMF:1101 Type1 Inactive DFGin 6.801 14.701 ABAminus -126.95, -66.04 -93.95, 105.24 -102.41, 30.18 293.69, 100.66 -84.84, -22.58 in-out in 8.305 Saltbr-out 3.933 HRD-out -78.59, 106.12 -94.17, 5.74 out-in-out SNCoio in-out ActLoopNT-in 2.828 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -136.91, -22.25 APE9-dihe-na -109.89, 157.52 APE8-dihe-in -56.01, 131.78 APE8-rot-in 308.02 APE67-dihe-in -60.99, -26.61 -52.03, -40.26 APE12-dist-out 14.28 APE11-dist-in 11.941 APE10-dist-in 7.36 APE9-dist-in 3.767 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 B 344 332 0 0 0 0 [[727, 1020]] 1.0 8bu5 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU5H 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 7.015 14.978 ABAminus -128.46, -54.53 -90.71, 103.12 -97.22, 31.8 290.43, 81.59 -85.33, -25.69 in-in in 8.479 Saltbr-in 3.527 HRD-in -73.55, -49.58 63.85, -4.76 in-in-in SNCiii in-in ActLoopNT-in 2.629 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.5, -28.02 APE9-dihe-na -97.36, 153.71 APE8-dihe-in -57.72, 135.61 APE8-rot-in 311.07 APE67-dihe-in -63.38, -27.52 -50.57, -39.59 APE12-dist-in 13.941 APE11-dist-in 12.128 APE10-dist-in 7.258 APE9-dist-in 3.497 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 H 344 331 0 0 0 0 [[727, 1020]] 1.0 8bu5 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU9H 715 1038 1490.0 RRC:61101 Type1 Inactive DFGin 6.897 15.028 ABAminus -130.72, -61.46 -86.64, 101.77 -100.72, 17.49 288.44, 80.02 -65.69, -13.23 in-in in 8.148 Saltbr-in 3.594 HRD-in -73.34, -52.41 71.89, 3.55 in-in-out SNCiio in-out ActLoopNT-in 2.783 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.4, -56.59 APE9-dihe-na -80.8, 152.68 APE8-dihe-in -61.03, 143.88 APE8-rot-out 47.91 APE67-dihe-in -59.68, -32.23 -55.45, -41.09 APE12-dist-in 13.723 APE11-dist-in 11.944 APE10-dist-in 7.007 APE9-dist-in 3.523 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 H 344 324 0 0 0 0 [[727, 1020]] 1.0 8bu9 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUAB 715 1039 1490.0 RVH:1101 Type1 Inactive DFGin 6.66 15.37 ABAminus -132.25, -47.59 -83.62, 100.61 -101.79, 23.05 288.11, 77.38 -59.48, -33.33 in-in in 8.072 Saltbr-in 2.933 HRD-in -66.14, -55.51 74.2, 0.02 in-in-in SNCiii in-in ActLoopNT-in 2.958 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.76, -47.66 APE9-dihe-na -82.97, 151.34 APE8-dihe-in -63.64, 142.13 APE8-rot-in 293.22 APE67-dihe-in -60.49, -35.73 -49.76, -42.55 APE12-dist-in 13.568 APE11-dist-in 11.766 APE10-dist-in 6.666 APE9-dist-in 3.543 K965R TPO893 TPO893 XRAY 3.193 0.202 0.225 B 344 325 0 0 0 0 [[727, 1020]] 1.0 8bua CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUAE 715 1033 1490.0 RVH:1101 Type1 Inactive DFGin 6.957 15.083 ABAminus -126.35, -57.7 -89.06, 99.95 -100.88, 19.34 288.21, 78.03 -60.59, -33.21 in-out in 8.364 Saltbr-out 3.678 HRD-in -67.84, -57.25 75.2, 0.85 out-in-out SNCoio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -70.04, -46.21 APE9-dihe-na -79.96, 152.67 APE8-dihe-in -66.28, 142.61 APE8-rot-out 169.95 APE67-dihe-in -61.55, -33.2 -51.95, -45.85 APE12-dist-in 13.685 APE11-dist-in 12.086 APE10-dist-in 6.766 APE9-dist-in 3.422 K965R TPO893 TPO893 XRAY 3.193 0.202 0.225 E 344 319 0 0 0 0 [[727, 1020]] 1.0 8bua CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUAH 715 1034 1490.0 RVH:1101 Type1 Inactive DFGin 6.883 15.42 ABAminus -126.04, -56.2 -88.9, 101.16 -97.82, 20.48 283.52, 73.51 -61.26, -31.16 in-in in 7.933 Saltbr-in 2.969 HRD-in -68.56, -58.56 73.11, 1.68 in-in-out SNCiio in-out ActLoopNT-in 2.897 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -115.42, -52.09 APE9-dihe-na -83.64, 155.3 APE8-dihe-in -61.52, 141.11 APE8-rot-in 293.24 APE67-dihe-in -60.38, -38.31 -51.83, -39.97 APE12-dist-out 14.088 APE11-dist-in 12.25 APE10-dist-in 7.273 APE9-dist-in 3.546 K965R TPO893 TPO893 XRAY 3.193 0.202 0.225 H 344 320 0 0 0 0 [[727, 1020]] 1.0 8bua CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUCB 715 1041 1490.0 RKO:61101 Type1 Inactive DFGin 6.835 15.495 ABAminus -130.47, -49.88 -100.7, 87.88 -87.1, 28.61 287.17, 76.07 -67.87, -32.97 in-in in 8.127 Saltbr-in 2.928 HRD-in -72.49, -52.56 71.47, 1.89 in-in-out SNCiio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.68, -53.4 APE9-dihe-na -81.9, 152.03 APE8-dihe-in -63.34, 145.38 APE8-rot-out 183.29 APE67-dihe-in -65.1, -32.1 -54.44, -34.81 APE12-dist-in 13.234 APE11-dist-in 11.425 APE10-dist-in 6.56 APE9-dist-in 3.613 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 B 344 327 0 0 0 0 [[727, 1020]] 1.0 8buc CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUDB 715 1043 1490.0 RP9:61101 Type1 Inactive DFGin 6.806 15.424 ABAminus -142.15, -16.91 -106.36, 87.13 -96.45, 32.21 289.44, 76.45 -77.57, -27.46 in-in in 8.02 Saltbr-in 3.49 HRD-in -66.52, -51.15 74.89, 1.88 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.04, -21.52 APE9-dihe-na -109.6, 155.4 APE8-dihe-in -62.09, 142.67 APE8-rot-in 309.35 APE67-dihe-in -60.6, -25.6 -60.57, -39.4 APE12-dist-in 13.191 APE11-dist-in 11.736 APE10-dist-in 6.693 APE9-dist-in 3.695 K965R TPO893 TPO893 XRAY 3.2 0.191 0.22 B 344 329 0 0 0 0 [[727, 1020]] 1.0 8bud CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUDH 715 1043 1490.0 RP9:61101 Type1 Inactive DFGin 6.946 15.357 ABAminus -136.05, -39.21 -99.68, 89.69 -94.42, 33.08 285.78, 76.86 -80.16, -27.09 in-in in 7.932 Saltbr-in 3.095 HRD-in -68.45, -57.7 74.71, 4.44 in-in-in SNCiii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.74, -26.44 APE9-dihe-na -108.9, 157.16 APE8-dihe-in -60.21, 144.65 APE8-rot-in 297.94 APE67-dihe-in -60.44, -27.56 -58.25, -38.75 APE12-dist-in 13.649 APE11-dist-in 11.734 APE10-dist-in 7.159 APE9-dist-in 3.655 K965R TPO893 TPO893 XRAY 3.2 0.191 0.22 H 344 329 0 0 0 0 [[727, 1020]] 1.0 8bud CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUEH 715 1043 1490.0 RVU:61101 Type1 Inactive DFGin 6.953 15.528 ABAminus -135.4, -31.77 -104.88, 88.01 -89.97, 37.83 286.95, 75.03 -83.73, -24.85 in-in in 8.095 Saltbr-in 3.053 HRD-in -72.11, -58.45 75.28, 1.16 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.38, -30.92 APE9-dihe-na -101.17, 153.28 APE8-dihe-in -59.63, 146.59 APE8-rot-in 309.03 APE67-dihe-in -63.21, -32.83 -55.37, -40.46 APE12-dist-in 13.521 APE11-dist-in 11.657 APE10-dist-in 6.904 APE9-dist-in 3.35 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 H 344 329 0 0 0 0 [[727, 1020]] 1.0 8bue CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUIB 715 1041 1490.0 RV6:1101 Type1 Inactive DFGin 6.848 15.385 ABAminus -131.36, -62.29 -89.48, 101.04 -94.93, 20.15 285.65, 74.39 -62.98, -21.99 in-in in 8.063 Saltbr-in 3.244 HRD-out -78.21, 99.43 -82.66, -35.16 in-in-in SNCiii in-in ActLoopNT-in 3.167 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.84, -19.18 APE9-dihe-na -128.33, 156.07 APE8-dihe-in -65.63, 140.55 APE8-rot-in 297.93 APE67-dihe-in -59.87, -34.95 -53.39, -43.04 APE12-dist-in 13.365 APE11-dist-in 10.961 APE10-dist-in 7.253 APE9-dist-in 4.181 K965R TPO893 TPO893 XRAY 3.5 0.184 0.221 B 344 327 0 0 0 0 [[727, 1020]] 1.0 8bui CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUIH 715 1038 1490.0 RV6:1101 Type1 Inactive DFGin 6.97 15.281 ABAminus -131.92, -50.63 -89.53, 95.29 -98.99, 14.99 287.64, 76.53 -67.14, -30.95 in-in in 8.151 Saltbr-in 3.277 HRD-out -79.19, 77.36 -62.47, -39.48 in-in-in SNCiii in-in ActLoopNT-in 2.993 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.57, -18.14 APE9-dihe-na -112.45, 157.67 APE8-dihe-in -65.3, 140.25 APE8-rot-in 297.23 APE67-dihe-in -58.21, -35.12 -53.14, -43.81 APE12-dist-in 13.665 APE11-dist-in 11.525 APE10-dist-in 7.005 APE9-dist-in 3.874 K965R TPO893 TPO893 XRAY 3.5 0.184 0.221 H 344 324 0 0 0 0 [[727, 1020]] 1.0 8bui CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BULH 715 1034 1490.0 RSU:1101 Type1 Inactive DFGin 7.002 15.334 ABAminus -135.61, -41.73 -99.52, 91.67 -88.52, 15.79 285.0, 79.41 -60.56, -30.48 in-in in 7.861 Saltbr-in 2.946 HRD-in -71.18, -53.58 72.73, 2.44 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.32, -27.33 APE9-dihe-na -113.19, 154.32 APE8-dihe-in -60.54, 141.61 APE8-rot-in 300.72 APE67-dihe-in -58.89, -38.82 -52.85, -42.63 APE12-dist-in 13.5 APE11-dist-in 11.612 APE10-dist-in 7.182 APE9-dist-in 3.818 None TPO893 TPO893 XRAY 3.4 0.179 0.215 H 344 320 0 0 0 0 [[727, 1020]] 1.0 8bul CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUNB 715 1041 1490.0 RNF:61101 Type1 Inactive DFGin 7.009 15.297 ABAminus -131.36, -49.43 -89.83, 91.44 -92.44, 32.63 287.3, 77.5 -75.27, -18.22 in-in in 7.748 Saltbr-in 3.279 HRD-in -75.67, -53.71 75.4, -0.11 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.12, -39.12 APE9-dihe-na -104.98, 151.97 APE8-dihe-in -58.93, 142.91 APE8-rot-in 279.94 APE67-dihe-in -65.42, -33.6 -55.06, -35.14 APE12-dist-in 13.388 APE11-dist-in 11.695 APE10-dist-in 7.099 APE9-dist-in 3.657 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 B 344 327 0 0 0 0 [[727, 1020]] 1.0 8bun CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUNH 715 1043 1490.0 RNF:61101 Type1 Inactive DFGin 7.045 15.286 ABAminus -125.24, -50.09 -100.69, 94.75 -92.24, 30.97 286.18, 71.82 -75.42, -18.26 in-in in 7.834 Saltbr-in 3.373 HRD-in -77.6, -54.36 73.0, -1.25 in-in-in SNCiii in-in ActLoopNT-in 2.74 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.56, -41.65 APE9-dihe-na -95.79, 153.05 APE8-dihe-in -58.87, 144.43 APE8-rot-in 305.25 APE67-dihe-in -65.98, -31.29 -55.83, -37.71 APE12-dist-in 13.775 APE11-dist-in 11.972 APE10-dist-in 6.957 APE9-dist-in 3.478 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 H 344 329 0 0 0 0 [[727, 1020]] 1.0 8bun CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUOB 715 1040 1490.0 RLC:1101 Type1 Inactive DFGin 6.577 15.644 ABAminus -146.64, 39.95 -136.73, 75.69 -99.12, 16.92 290.75, 79.72 -67.9, -33.68 in-in in 8.213 Saltbr-in 2.831 HRD-in -67.45, -41.41 63.58, -11.91 in-in-in SNCiii in-in ActLoopNT-in 2.979 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.89, -24.96 APE9-dihe-na -114.96, 153.64 APE8-dihe-in -59.59, 137.04 APE8-rot-in 298.26 APE67-dihe-in -58.73, -33.95 -50.83, -38.96 APE12-dist-in 13.278 APE11-dist-in 11.409 APE10-dist-in 7.043 APE9-dist-in 3.916 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 B 344 326 0 0 0 0 [[727, 1020]] 1.0 8buo CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BURE 715 1040 1490.0 RQU:61101 Type1 Inactive DFGin 6.885 15.844 ABAminus -134.08, -49.7 -100.21, 93.56 -92.36, 24.23 284.18, 80.41 -66.46, -36.08 in-in in 8.216 Saltbr-in 2.802 HRD-in -63.9, -48.8 70.15, 6.43 in-in-out SNCiio in-out ActLoopNT-in 2.927 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -92.25, -40.02 APE9-dihe-na -84.05, 150.42 APE8-dihe-in -60.84, 144.54 APE8-rot-out 183.23 APE67-dihe-in -64.31, -32.85 -49.71, -40.37 APE12-dist-in 12.244 APE11-dist-in 11.971 APE10-dist-in 6.533 APE9-dist-in 3.85 K965R TPO893 TPO893 XRAY 3.64 0.192 0.234 E 344 326 0 0 0 0 [[727, 1020]] 1.0 8bur CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUSH 715 1044 1490.0 RMX:1101 Type1 Inactive DFGin 6.901 15.069 ABAminus -143.82, 12.24 -131.03, 98.54 -110.73, 33.01 294.28, 70.2 -74.22, -18.61 in-in in 7.947 Saltbr-in 3.124 HRD-in -74.26, -49.18 68.04, 9.28 in-in-in SNCiii in-in ActLoopNT-in 2.847 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -102.73, -48.18 APE9-dihe-na -92.8, 152.41 APE8-dihe-in -59.01, 141.68 APE8-rot-in 303.45 APE67-dihe-in -64.79, -31.26 -52.5, -37.48 APE12-dist-in 13.661 APE11-dist-in 11.986 APE10-dist-in 7.2 APE9-dist-in 3.737 K965R TPO893 TPO893 XRAY 3.26 0.209 0.228 H 344 330 0 0 0 0 [[727, 1020]] 1.0 8bus CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUTB 715 1039 1490.0 RQ5:61101 Type1 Inactive DFGin 7.056 15.396 ABAminus -130.15, -50.58 -94.08, 102.79 -101.3, 34.01 287.2, 80.24 -71.28, -33.81 in-in in 8.178 Saltbr-in 3.454 HRD-in -68.35, -50.74 72.26, 0.96 in-in-out SNCiio in-out ActLoopNT-in 2.855 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -102.11, -52.89 APE9-dihe-na -83.71, 152.96 APE8-dihe-in -63.18, 146.03 APE8-rot-out 183.88 APE67-dihe-in -64.84, -30.01 -53.45, -39.74 APE12-dist-in 13.152 APE11-dist-in 11.752 APE10-dist-in 6.876 APE9-dist-in 3.664 K965R TPO893 TPO893 XRAY 3.25 0.198 0.217 B 344 325 0 0 0 0 [[727, 1020]] 1.0 8but CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUTH 715 1043 1490.0 RQ5:61101 Type1 Inactive DFGin 7.093 15.421 ABAminus -128.56, -49.4 -93.56, 100.15 -99.66, 30.54 282.78, 78.32 -73.44, -31.71 in-in in 8.09 Saltbr-in 3.514 HRD-in -72.59, -52.14 71.01, -0.2 in-in-in SNCiii in-in ActLoopNT-in 2.746 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -103.31, -52.45 APE9-dihe-na -84.96, 155.97 APE8-dihe-in -63.11, 145.04 APE8-rot-in 301.85 APE67-dihe-in -65.27, -28.99 -54.91, -40.74 APE12-dist-in 13.688 APE11-dist-in 12.03 APE10-dist-in 7.147 APE9-dist-in 3.489 K965R TPO893 TPO893 XRAY 3.25 0.198 0.217 H 344 329 0 0 0 0 [[727, 1020]] 1.0 8but CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
7NXKA 715 1040 1490.0 UUB:2000 Type1 Inactive DFGin 7.399 15.487 ABAminus -95.46, -72.72 -129.88, 136.0 -106.22, 48.24 290.77, 75.67 -65.42, -30.99 in-none in 8.908 Saltbr-none 999.0 HRD-out -77.5, 146.77 -128.84, 17.49 none-in-out SNCnio in-out ActLoopNT-in 2.97 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.63, -48.96 APE9-dihe-na -98.39, 153.96 APE8-dihe-in -58.36, 147.85 APE8-rot-out 42.54 APE67-dihe-in -71.34, -26.96 -59.32, -29.48 APE12-dist-in 12.842 APE11-dist-in 11.116 APE10-dist-in 6.75 APE9-dist-in 3.445 None TPO893 TPO893 XRAY 3.0 0.222 0.264 A 351 322 4 0 0 0 [[727, 1020]] 1.0 7nxk CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
9FMRE 714 1042 1490.0 RMF:61101 Type1 Inactive DFGin 6.793 14.64 ABAminus -113.83, -79.52 -84.15, 118.47 -115.27, 16.16 293.54, 100.02 -64.02, -34.33 in-out in 9.633 Saltbr-out 3.612 HRD-out -79.17, 82.22 -59.96, 8.89 out-in-out SNCoio in-out ActLoopNT-in 3.026 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -148.14, -27.51 APE9-dihe-na -104.44, 148.12 APE8-dihe-in -51.45, 137.55 APE8-rot-in 306.02 APE67-dihe-in -70.5, -21.3 -54.61, -36.19 APE12-dist-out 14.298 APE11-dist-in 12.211 APE10-dist-in 7.469 APE9-dist-in 3.767 None TPO893 TPO893 XRAY 3.9 0.209 0.25 E 351 329 0 0 0 0 [[727, 1020]] 1.0 9fmr CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
9FMRH 714 1044 1490.0 RMF:61101 Type1 Inactive DFGin 6.801 14.603 ABAminus -113.95, -78.4 -84.85, 124.02 -118.87, 17.95 291.29, 89.7 -63.88, -35.4 in-in in 8.592 Saltbr-in 3.552 HRD-in -72.47, -40.65 59.82, 5.57 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.74, -27.71 APE9-dihe-na -103.25, 148.34 APE8-dihe-in -51.07, 136.63 APE8-rot-in 306.14 APE67-dihe-in -69.99, -21.15 -54.39, -34.8 APE12-dist-in 13.823 APE11-dist-in 12.098 APE10-dist-in 7.255 APE9-dist-in 3.608 None TPO893 TPO893 XRAY 3.9 0.209 0.25 H 351 331 0 0 0 0 [[727, 1020]] 1.0 9fmr CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
4CXAA 718 1050 1490.0 ANP:2051 ATPlike Inactive DFGin 6.436 15.022 BLAminus -127.47, 178.63 59.83, 84.78 -103.34, 39.58 291.64, 72.71 -78.99, -14.54 in-in in 8.178 Saltbr-in 2.513 HRD-in -89.68, -50.66 63.81, 17.68 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.43, 159.2 APE9-dihe-na 63.92, 139.76 APE8-dihe-in -56.37, 145.01 APE8-rot-out 63.76 APE67-dihe-in -64.68, -22.99 -55.23, -40.79 APE12-dist-in 13.212 APE11-dist-in 11.662 APE10-dist-in 7.363 APE9-dist-in 3.506 None TPO893 TPO893 XRAY 3.15 0.224 0.279 A 340 330 3 0 0 1 [[727, 1020]] 1.0 4cxa CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
4NSTA 716 1046 1490.0 ADP:1101 ATPlike Inactive DFGin 6.978 15.111 BLAminus -127.54, 179.84 60.58, 76.06 -95.3, 23.79 283.73, 86.71 -65.43, -16.77 in-in in 8.988 Saltbr-in 3.031 HRD-in -82.28, -56.37 71.8, 9.39 in-in-out SNCiio in-out ActLoopNT-in 2.956 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.59, 153.12 APE9-dihe-na 76.09, 132.29 APE8-dihe-in -60.41, 149.83 APE8-rot-out 85.48 APE67-dihe-in -64.83, -28.79 -60.07, -39.7 APE12-dist-in 13.247 APE11-dist-in 11.273 APE10-dist-in 6.995 APE9-dist-in 3.461 None TPO893 TPO893 XRAY 2.2 0.198 0.24 A 351 323 8 0 0 0 [[727, 1020]] 1.0 4nst CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
4NSTC 717 1045 1490.0 ADP:1101 ATPlike Inactive DFGin 6.972 15.168 BLAminus -122.49, -178.57 55.97, 75.42 -92.86, 20.68 283.24, 86.31 -56.98, -20.08 in-in in 8.863 Saltbr-in 2.957 HRD-in -69.12, -51.54 66.96, 15.75 in-in-out SNCiio in-out ActLoopNT-in 2.928 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.74, 152.42 APE9-dihe-na 82.09, 126.12 APE8-dihe-in -62.22, 152.62 APE8-rot-out 78.32 APE67-dihe-in -63.16, -30.08 -57.73, -42.25 APE12-dist-in 13.202 APE11-dist-in 11.267 APE10-dist-in 6.942 APE9-dist-in 3.705 None TPO893 TPO893 XRAY 2.2 0.198 0.24 C 351 318 11 0 0 1 [[727, 1020]] 1.0 4nst CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
4UN0C 719 1036 1490.0 No_ligand No_ligand Inactive DFGin 7.232 15.503 BLAminus -124.23, -178.57 61.68, 76.73 -100.84, 26.92 286.01, 6.79 -65.68, -44.77 in-none in 8.995 Saltbr-none 999.0 HRD-in -69.99, -50.49 63.23, 23.44 none-in-out SNCnio in-out ActLoopNT-in 2.936 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -139.84, 155.57 APE9-dihe-na 72.34, -14.08 APE8-dihe-out 67.52, 158.6 APE8-rot-out 70.66 APE67-dihe-in -58.83, -37.69 -56.4, -50.16 APE12-dist-in 13.127 APE11-dist-in 10.764 APE10-dist-in 7.944 APE9-dist-in 3.927 None TPO893 TPO893 XRAY 3.15 0.217 0.271 C 326 309 9 0 0 0 [[727, 1020]] 1.0 4un0 CMGC_CDK12_HUMAN CMGC 2.2e-84 289.2 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
4UN0D 723 1024 1490.0 No_ligand No_ligand Inactive DFGin 7.195 15.47 BLAminus -123.96, -178.26 62.11, 76.94 -101.1, 26.4 286.66, 6.77 -66.07, -44.8 in-none in 8.959 Saltbr-none 999.0 HRD-in -70.01, -50.55 63.3, 23.26 none-in-out SNCnio in-out ActLoopNT-in 2.807 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -139.6, 156.23 APE9-dihe-na 75.54, -12.58 APE8-dihe-out 66.76, 157.7 APE8-rot-out 70.35 APE67-dihe-in -58.41, -37.99 -56.68, -49.87 APE12-dist-in 13.211 APE11-dist-in 11.101 APE10-dist-in 7.972 APE9-dist-in 3.956 None TPO893 TPO893 XRAY 3.15 0.217 0.271 D 326 277 25 0 0 5 [[727, 1020]] 1.0 4un0 CMGC_CDK12_HUMAN CMGC 2.2e-84 289.2 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
4CXAC 718 1048 1490.0 No_ligand No_ligand Inactive DFGin 7.199 15.248 BLAminus -126.07, 177.23 58.72, 82.97 -102.36, 37.62 286.53, 69.22 -80.81, -13.97 in-none in 8.046 Saltbr-none 999.0 HRD-in -86.15, -47.73 62.33, 17.56 none-in-out SNCnio in-out ActLoopNT-in 3.047 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.86, 161.73 APE9-dihe-na 68.73, 142.31 APE8-dihe-in -55.95, 146.27 APE8-rot-out 63.52 APE67-dihe-in -66.87, -27.84 -54.72, -39.98 APE12-dist-in 13.18 APE11-dist-in 11.907 APE10-dist-in 7.481 APE9-dist-in 3.577 None TPO893 TPO893 XRAY 3.15 0.224 0.279 C 340 331 0 0 0 0 [[727, 1020]] 1.0 4cxa CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU2E 715 1039 1490.0 No_ligand No_ligand Inactive DFGin 7.379 15.57 BLAminus -136.39, 179.92 48.57, 72.52 -89.87, 33.71 279.3, 90.07 -78.07, -11.47 in-in in 7.911 Saltbr-in 3.147 HRD-in -74.54, -52.71 71.43, 6.76 in-in-out SNCiio in-out ActLoopNT-in 2.869 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.65, -39.48 APE9-dihe-na -100.87, 155.56 APE8-dihe-in -58.32, 146.43 APE8-rot-out 175.64 APE67-dihe-in -62.37, -35.72 -53.25, -43.67 APE12-dist-in 13.394 APE11-dist-in 12.571 APE10-dist-in 7.149 APE9-dist-in 3.738 K965R TPO893 TPO893 XRAY 3.13 0.193 0.217 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bu2 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUDE 715 1043 1490.0 No_ligand No_ligand Inactive DFGin 7.272 15.453 BLAminus -143.83, -177.07 47.13, 79.14 -96.0, 35.58 285.18, 78.34 -74.8, -28.12 in-in in 8.105 Saltbr-in 3.075 HRD-in -66.78, -51.99 75.75, 3.43 in-in-out SNCiio in-out ActLoopNT-in 2.985 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -100.45, -19.67 APE9-dihe-na -95.18, 153.43 APE8-dihe-in -60.73, 146.92 APE8-rot-out 173.58 APE67-dihe-in -62.46, -23.72 -59.64, -41.84 APE12-dist-in 13.058 APE11-dist-in 12.497 APE10-dist-in 6.772 APE9-dist-in 3.404 K965R TPO893 TPO893 XRAY 3.2 0.191 0.22 E 344 329 0 0 0 0 [[727, 1020]] 1.0 8bud CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUGE 715 1039 1490.0 No_ligand No_ligand Inactive DFGin 7.508 15.743 BLAminus -142.95, -165.93 46.31, 64.06 -92.32, 17.1 280.22, 84.99 -61.9, -35.84 in-in in 8.212 Saltbr-in 3.113 HRD-in -63.09, -51.61 71.91, 6.47 in-in-out SNCiio in-out ActLoopNT-in 2.956 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -74.97, -44.52 APE9-dihe-na -69.42, 151.3 APE8-dihe-in -61.28, 146.55 APE8-rot-out 168.8 APE67-dihe-in -63.35, -29.72 -54.01, -46.01 APE12-dist-in 13.222 APE11-dist-in 12.722 APE10-dist-in 6.946 APE9-dist-in 3.431 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bug CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
6B3EA 717 1036 1490.0 CJM:1102 Type1 Inactive DFGin 7.202 14.766 BLAminus -121.7, 178.92 59.35, 79.81 -95.65, 26.66 285.79, 81.49 -61.82, -29.55 in-in in 8.699 Saltbr-in 3.05 HRD-in -76.48, -54.37 70.53, 12.96 in-in-out SNCiio in-out ActLoopNT-in 2.914 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.0, 155.78 APE9-dihe-na 76.06, 131.42 APE8-dihe-in -60.49, 145.1 APE8-rot-out 86.32 APE67-dihe-in -63.58, -25.36 -47.54, -46.44 APE12-dist-in 13.355 APE11-dist-in 11.458 APE10-dist-in 6.977 APE9-dist-in 3.497 None TPO893 TPO893 XRAY 3.06 0.191 0.212 A 320 310 10 0 0 0 [[727, 1020]] 1.0 6b3e CMGC_CDK12_HUMAN CMGC 2e-84 289.3 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
6B3EC 719 1036 1490.0 CJM:1103 Type1 Inactive DFGin 7.173 14.621 BLAminus -121.27, -179.9 57.69, 80.64 -96.21, 26.0 285.96, 80.56 -59.62, -30.89 in-in in 8.528 Saltbr-in 2.838 HRD-in -74.96, -53.91 69.51, 14.07 in-in-out SNCiio in-out ActLoopNT-in 2.894 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.93, 154.64 APE9-dihe-na 78.03, 130.48 APE8-dihe-in -61.1, 145.82 APE8-rot-out 85.07 APE67-dihe-in -62.57, -25.75 -47.61, -47.19 APE12-dist-in 13.267 APE11-dist-in 11.359 APE10-dist-in 6.944 APE9-dist-in 3.562 None TPO893 TPO893 XRAY 3.06 0.191 0.212 C 320 308 10 0 0 0 [[727, 1020]] 1.0 6b3e CMGC_CDK12_HUMAN CMGC 2e-84 289.3 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
5ACBC 716 1040 1490.0 5I1:2000 Type1 Inactive DFGin 7.442 15.98 BLAminus -120.77, 171.13 69.09, 68.44 -91.07, 27.42 288.67, 78.45 -57.05, -52.5 in-in in 8.369 Saltbr-in 2.878 HRD-in -75.39, -52.07 67.69, 20.88 in-in-out SNCiio in-out ActLoopNT-in 2.804 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.05, 158.72 APE9-dihe-na 71.72, 133.31 APE8-dihe-in -62.63, 141.8 APE8-rot-out 192.05 APE67-dihe-in -62.93, -27.37 -47.97, -41.23 APE12-dist-in 13.642 APE11-dist-in 11.666 APE10-dist-in 7.394 APE9-dist-in 3.53 None TPO893 TPO893 XRAY 2.7 0.223 0.262 C 340 325 0 0 0 0 [[727, 1020]] 1.0 5acb CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
5ACBD 718 1044 1490.0 5I1:2000 Type1 Inactive DFGin 7.452 16.011 BLAminus -121.14, 171.65 68.87, 69.17 -92.34, 27.19 288.77, 78.24 -58.4, -50.08 in-in in 8.349 Saltbr-in 2.875 HRD-in -75.87, -51.87 67.36, 21.14 in-in-out SNCiio in-out ActLoopNT-in 2.811 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.18, 158.62 APE9-dihe-na 71.07, 133.26 APE8-dihe-in -63.22, 142.55 APE8-rot-out 191.44 APE67-dihe-in -63.33, -26.97 -48.15, -41.58 APE12-dist-in 13.698 APE11-dist-in 11.768 APE10-dist-in 7.486 APE9-dist-in 3.567 None TPO893 TPO893 XRAY 2.7 0.223 0.262 D 340 320 7 0 0 3 [[727, 1020]] 1.0 5acb CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
9JK1A 717 1039 1490.0 A1EB3:1202 Type1 Inactive DFGin 7.136 16.194 BLAminus -133.53, 173.61 54.27, 71.41 -88.96, 16.92 270.96, 77.73 -63.15, -30.31 in-in in 8.497 Saltbr-in 3.285 HRD-in -81.17, -44.88 64.66, 14.44 in-in-out SNCiio in-out ActLoopNT-in 2.857 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.0, -26.54 APE9-dihe-na -103.25, 143.89 APE8-dihe-in -52.76, 144.9 APE8-rot-out 169.48 APE67-dihe-in -66.06, -18.64 -58.71, -34.25 APE12-dist-in 13.75 APE11-dist-in 12.265 APE10-dist-in 7.176 APE9-dist-in 3.888 None TPO893 TPO893 XRAY 2.72 0.249 0.267 A 340 311 12 0 0 2 [[727, 1020]] 1.0 9jk1 CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
9JK1B 715 1039 1490.0 A1EB3:1101 Type1 Inactive DFGin 6.974 15.796 BLAminus -131.76, 174.62 55.08, 70.72 -88.19, 16.31 271.01, 79.18 -62.74, -29.13 in-in in 8.517 Saltbr-in 3.036 HRD-in -81.5, -44.39 65.05, 13.56 in-in-out SNCiio in-out ActLoopNT-in 3.15 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.88, -41.9 APE9-dihe-na -106.09, 143.29 APE8-dihe-in -52.94, 146.84 APE8-rot-out 167.82 APE67-dihe-in -65.97, -16.6 -59.29, -37.44 APE12-dist-in 13.616 APE11-dist-in 11.584 APE10-dist-in 7.243 APE9-dist-in 3.661 None TPO893 TPO893 XRAY 2.72 0.249 0.267 B 340 315 10 0 0 0 [[727, 1020]] 1.0 9jk1 CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
6TD3B 715 1047 1490.0 RC8:1101 Type1 Inactive DFGin 7.072 15.376 BLAminus -144.85, 177.87 66.18, 66.81 -86.27, 29.11 284.0, 81.86 -68.57, -26.95 in-in in 7.94 Saltbr-in 3.098 HRD-in -75.0, -46.5 66.33, 3.67 in-in-out SNCiio in-out ActLoopNT-in 2.962 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.74, 152.33 APE9-dihe-na 70.44, 153.31 APE8-dihe-in -72.7, 152.08 APE8-rot-out 190.09 APE67-dihe-in -62.32, -35.85 -49.81, -38.44 APE12-dist-in 13.58 APE11-dist-in 10.993 APE10-dist-in 7.153 APE9-dist-in 3.643 K965R TPO893 TPO893 XRAY 3.46 0.195 0.22 B 344 333 0 0 0 0 [[727, 1020]] 1.0 6td3 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
6TD3H 715 1047 1490.0 RC8:1101 Type1 Inactive DFGin 7.008 15.067 BLAminus -125.85, 165.87 77.73, 76.18 -92.06, 29.13 290.22, 73.9 -71.24, -38.15 in-in in 7.898 Saltbr-in 3.073 HRD-in -75.01, -45.87 63.18, 11.24 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -152.2, 169.13 APE9-dihe-na 75.43, 19.72 APE8-dihe-out 60.33, 162.48 APE8-rot-out 98.13 APE67-dihe-in -64.24, -27.06 -78.21, -44.67 APE12-dist-in 13.905 APE11-dist-in 11.902 APE10-dist-in 7.407 APE9-dist-in 3.189 K965R TPO893 TPO893 XRAY 3.46 0.195 0.22 H 344 333 0 0 0 0 [[727, 1020]] 1.0 6td3 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU1E 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 7.068 15.214 BLAminus -136.12, -177.54 44.75, 87.14 -99.51, 30.27 285.35, 73.68 -68.31, -25.33 in-in in 7.794 Saltbr-in 3.1 HRD-in -77.94, -49.77 74.02, -0.64 in-in-out SNCiio in-out ActLoopNT-in 2.691 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.97, -45.94 APE9-dihe-na -80.52, 149.74 APE8-dihe-in -60.97, 145.17 APE8-rot-out 178.02 APE67-dihe-in -66.77, -27.56 -51.22, -43.09 APE12-dist-in 13.018 APE11-dist-in 12.227 APE10-dist-in 6.992 APE9-dist-in 3.549 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 E 344 330 0 0 0 0 [[727, 1020]] 1.0 8bu1 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU4E 715 1039 1490.0 RQL:61101 Type1 Inactive DFGin 7.468 15.54 BLAminus -141.1, 177.81 60.96, 67.17 -93.67, 20.14 286.75, 91.51 -68.13, -33.02 in-out in 8.589 Saltbr-out 5.378 HRD-in -65.76, -60.59 77.41, 5.82 out-in-out SNCoio in-out ActLoopNT-in 3.03 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -92.44, -31.45 APE9-dihe-na -85.2, 150.66 APE8-dihe-in -60.73, 147.65 APE8-rot-out 173.82 APE67-dihe-in -63.61, -27.41 -58.33, -41.33 APE12-dist-in 13.082 APE11-dist-in 12.596 APE10-dist-in 6.898 APE9-dist-in 3.368 K965R TPO893 TPO893 XRAY 3.09 0.205 0.223 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bu4 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU6E 715 1038 1490.0 RQE:61101 Type1 Inactive DFGin 6.904 14.793 BLAminus -142.16, 173.3 46.61, 77.13 -86.78, 22.75 290.79, 69.64 -59.06, -38.89 in-out in 8.466 Saltbr-out 3.779 HRD-in -71.31, -54.36 76.0, -0.16 out-in-out SNCoio in-out ActLoopNT-in 2.982 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -121.41, -43.86 APE9-dihe-na -68.68, 149.74 APE8-dihe-in -53.47, 142.92 APE8-rot-out 167.33 APE67-dihe-in -57.01, -34.74 -57.51, -41.34 APE12-dist-in 13.103 APE11-dist-in 13.082 APE10-dist-in 7.18 APE9-dist-in 3.547 K965R TPO893 TPO893 XRAY 3.45 0.219 0.249 E 344 324 0 0 0 0 [[727, 1020]] 1.0 8bu6 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU7E 715 1043 1490.0 RS5:1101 Type1 Inactive DFGin 6.913 15.331 BLAminus -151.87, 179.81 58.39, 58.15 -75.44, 35.18 288.34, 71.23 -65.18, -38.03 in-in in 7.757 Saltbr-in 2.771 HRD-in -65.82, -48.21 71.8, 2.22 in-in-out SNCiio in-out ActLoopNT-in 2.88 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -76.27, -35.49 APE9-dihe-na -79.69, 146.79 APE8-dihe-in -61.33, 142.24 APE8-rot-out 178.46 APE67-dihe-in -63.9, -29.29 -50.85, -42.32 APE12-dist-in 12.527 APE11-dist-in 12.336 APE10-dist-in 6.449 APE9-dist-in 3.489 K965R TPO893 TPO893 XRAY 3.245 0.193 0.219 E 344 329 0 0 0 0 [[727, 1020]] 1.0 8bu7 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU9E 715 1039 1490.0 RRC:61101 Type1 Inactive DFGin 6.994 15.296 BLAminus -144.01, 174.3 58.02, 76.59 -92.29, 23.22 284.15, 79.53 -66.56, -16.01 in-in in 7.926 Saltbr-in 2.978 HRD-in -72.29, -52.87 75.22, 4.09 in-in-out SNCiio in-out ActLoopNT-in 2.953 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -79.11, -41.8 APE9-dihe-na -74.19, 150.88 APE8-dihe-in -62.82, 143.67 APE8-rot-out 166.93 APE67-dihe-in -61.65, -28.3 -55.31, -42.74 APE12-dist-in 13.003 APE11-dist-in 12.713 APE10-dist-in 6.892 APE9-dist-in 3.475 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bu9 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUBB 715 1041 1490.0 RNU:61101 Type1 Inactive DFGin 7.183 15.861 BLAminus -140.81, -179.71 59.34, 42.69 -57.7, -43.03 281.93, 72.19 -135.84, 169.59 in-in in 7.816 Saltbr-in 3.03 HRD-out -85.59, 106.33 -67.25, -35.7 in-out-out SNCioo out-out ActLoopNT-out 15.083 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -58.9, -41.94 APE9-dihe-na -63.9, -43.28 APE8-dihe-out -57.35, -36.53 APE8-rot-in 303.78 APE67-dihe-in -55.9, -22.59 -60.27, -40.25 APE12-dist-in 10.517 APE11-dist-in 13.521 APE10-dist-out 17.379 APE9-dist-out 11.733 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 B 344 327 0 0 0 0 [[727, 1020]] 1.0 8bub CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUBE 715 1043 1490.0 RNU:61101 Type1 Inactive DFGin 7.121 15.718 BLAminus -151.03, 179.83 54.33, 46.25 -61.28, -40.39 279.04, 68.48 -138.85, 169.0 in-in in 8.261 Saltbr-in 2.913 HRD-out -90.61, 99.83 -68.22, -35.13 in-out-out SNCioo out-out ActLoopNT-out 14.624 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -60.24, -43.43 APE9-dihe-na -66.88, -44.0 APE8-dihe-out -57.36, -41.95 APE8-rot-in 294.1 APE67-dihe-in -53.67, -21.91 -61.1, -39.92 APE12-dist-in 10.606 APE11-dist-out 14.793 APE10-dist-out 17.915 APE9-dist-out 11.298 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 E 344 329 0 0 0 0 [[727, 1020]] 1.0 8bub CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUCE 715 1039 1490.0 RKO:61101 Type1 Inactive DFGin 7.236 15.335 BLAminus -141.04, 176.79 52.98, 78.31 -91.94, 30.22 286.84, 76.41 -65.41, -31.19 in-in in 7.961 Saltbr-in 2.908 HRD-in -69.25, -49.18 71.49, 1.27 in-in-out SNCiio in-out ActLoopNT-in 2.87 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -94.07, -41.15 APE9-dihe-na -76.31, 151.65 APE8-dihe-in -63.11, 145.53 APE8-rot-out 179.86 APE67-dihe-in -66.95, -27.99 -55.33, -37.54 APE12-dist-in 12.996 APE11-dist-in 12.54 APE10-dist-in 6.8 APE9-dist-in 3.464 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8buc CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUEE 715 1039 1490.0 RVU:61101 Type1 Inactive DFGin 7.242 15.496 BLAminus -141.72, -174.7 47.09, 73.46 -90.8, 38.01 284.87, 78.5 -78.36, -22.84 in-in in 7.983 Saltbr-in 3.324 HRD-in -72.61, -56.11 78.07, 3.62 in-in-out SNCiio in-out ActLoopNT-in 2.863 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -101.94, -25.35 APE9-dihe-na -96.92, 153.79 APE8-dihe-in -59.83, 147.51 APE8-rot-out 172.74 APE67-dihe-in -64.75, -28.9 -55.27, -41.29 APE12-dist-in 12.98 APE11-dist-in 12.541 APE10-dist-in 7.005 APE9-dist-in 3.371 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bue CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUFE 715 1043 1490.0 RW6:61101 Type1 Inactive DFGin 7.236 15.613 BLAminus -139.81, -179.98 50.46, 82.76 -97.71, 35.51 286.32, 76.93 -72.96, -20.08 in-in in 8.207 Saltbr-in 3.083 HRD-in -73.52, -52.81 75.99, 1.49 in-in-out SNCiio in-out ActLoopNT-in 3.139 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -94.42, -47.71 APE9-dihe-na -72.58, 149.04 APE8-dihe-in -62.45, 149.79 APE8-rot-out 175.62 APE67-dihe-in -64.49, -29.41 -54.77, -42.48 APE12-dist-in 12.629 APE11-dist-in 12.345 APE10-dist-in 6.616 APE9-dist-in 3.281 K965R TPO893 TPO893 XRAY 3.3 0.185 0.22 E 344 329 0 0 0 0 [[727, 1020]] 1.0 8buf CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUHE 715 1034 1490.0 RR9:61101 Type1 Inactive DFGin 7.186 15.729 BLAminus -148.68, -172.98 46.52, 61.7 -84.29, 18.93 287.47, 71.85 -64.36, -25.08 in-in in 8.292 Saltbr-in 3.146 HRD-in -67.53, -47.52 70.08, 2.73 in-in-out SNCiio in-out ActLoopNT-in 2.955 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -76.87, -40.28 APE9-dihe-na -73.29, 157.3 APE8-dihe-in -67.11, 147.48 APE8-rot-out 173.32 APE67-dihe-in -62.13, -36.27 -57.69, -39.06 APE12-dist-in 13.369 APE11-dist-in 12.874 APE10-dist-in 7.086 APE9-dist-in 3.487 K965R TPO893 TPO893 XRAY 3.79 0.189 0.232 E 344 320 0 0 0 0 [[727, 1020]] 1.0 8buh CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUIE 715 1039 1490.0 RV6:1101 Type1 Inactive DFGin 7.539 15.558 BLAminus -143.87, -178.18 39.61, 79.76 -92.26, 22.29 284.74, 80.02 -58.61, -17.16 in-out in 8.11 Saltbr-out 3.715 HRD-out -75.62, 149.49 -131.37, 158.61 out-in-out SNCoio in-out ActLoopNT-in 3.167 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -99.18, -17.3 APE9-dihe-na -88.48, 155.1 APE8-dihe-in -64.43, 139.92 APE8-rot-out 15.61 APE67-dihe-in -61.18, -34.77 -50.17, -41.15 APE12-dist-in 13.019 APE11-dist-in 12.914 APE10-dist-in 7.019 APE9-dist-out 6.027 K965R TPO893 TPO893 XRAY 3.5 0.184 0.221 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bui CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUJE 715 1043 1490.0 RUW:1101 Type1 Inactive DFGin 7.403 15.559 BLAminus -141.86, -179.96 50.47, 61.92 -80.29, 20.39 278.49, 79.05 -71.07, 143.46 in-out in 7.788 Saltbr-out 4.375 HRD-in -62.58, -56.77 78.09, -0.63 out-in-in SNCoii in-in ActLoopNT-in 3.099 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.26, -45.94 APE9-dihe-na -81.75, 154.86 APE8-dihe-in -61.95, 146.07 APE8-rot-in 291.01 APE67-dihe-in -60.95, -32.29 -58.05, -37.51 APE12-dist-in 12.792 APE11-dist-in 12.176 APE10-dist-in 7.086 APE9-dist-in 3.43 K965R TPO893 TPO893 XRAY 3.62 0.164 0.206 E 344 329 0 0 0 0 [[727, 1020]] 1.0 8buj CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUKE 715 1039 1490.0 RWE:61101 Type1 Inactive DFGin 7.127 15.205 BLAminus -148.82, 179.05 51.44, 70.31 -90.34, 37.33 288.85, 69.46 -77.88, -21.75 in-in in 8.114 Saltbr-in 2.955 HRD-in -69.03, -55.19 75.3, 6.2 in-in-out SNCiio in-out ActLoopNT-in 3.068 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -77.16, -37.78 APE9-dihe-na -75.17, 151.97 APE8-dihe-in -63.51, 147.07 APE8-rot-out 163.95 APE67-dihe-in -64.24, -27.64 -56.09, -42.19 APE12-dist-in 12.843 APE11-dist-in 12.42 APE10-dist-in 6.565 APE9-dist-in 3.319 K965R TPO893 TPO893 XRAY 3.41 0.186 0.21 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8buk CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUNE 715 1039 1490.0 RNF:61101 Type1 Inactive DFGin 7.217 15.313 BLAminus -143.55, -179.06 50.55, 77.42 -92.12, 34.85 285.27, 76.47 -72.26, -18.51 in-in in 7.824 Saltbr-in 3.046 HRD-in -77.13, -53.65 75.0, -0.22 in-in-out SNCiio in-out ActLoopNT-in 2.924 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.31, -34.23 APE9-dihe-na -92.08, 151.91 APE8-dihe-in -57.84, 145.99 APE8-rot-out 175.35 APE67-dihe-in -65.98, -29.37 -55.72, -38.5 APE12-dist-in 13.18 APE11-dist-in 12.611 APE10-dist-in 7.008 APE9-dist-in 3.432 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bun CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUOE 715 1040 1490.0 RLC:1101 Type1 Inactive DFGin 6.942 15.62 BLAminus -143.37, -172.35 44.48, 74.17 -91.23, 22.68 280.06, 81.2 -62.03, -28.06 in-in in 8.068 Saltbr-in 3.056 HRD-out -76.67, 113.14 -91.39, -21.48 in-in-in SNCiii in-in ActLoopNT-in 2.893 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.19, -25.24 APE9-dihe-na -90.88, 153.8 APE8-dihe-in -61.01, 138.91 APE8-rot-in 296.79 APE67-dihe-in -57.07, -33.65 -55.69, -42.2 APE12-dist-in 12.516 APE11-dist-in 12.554 APE10-dist-in 6.839 APE9-dist-in 3.735 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 E 344 326 0 0 0 0 [[727, 1020]] 1.0 8buo CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUPB 715 1027 1490.0 RWN:61101 Type1 Inactive DFGin 7.376 16.292 BLAminus -145.67, -178.63 51.5, 56.05 -75.52, 21.8 268.89, 78.21 -77.2, 158.24 in-in in 7.988 Saltbr-in 3.547 HRD-out -85.14, 78.87 -56.17, -33.42 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.18, -2.81 APE9-dihe-na -129.4, 158.55 APE8-dihe-in -65.53, 143.29 APE8-rot-in 297.85 APE67-dihe-in -63.16, -33.23 -55.07, -39.7 APE12-dist-in 12.626 APE11-dist-in 11.325 APE10-dist-in 6.955 APE9-dist-in 4.075 K965R TPO893 TPO893 XRAY 3.41 0.201 0.223 B 344 313 0 0 0 0 [[727, 1020]] 1.0 8bup CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUPE 715 1027 1490.0 RWN:61101 Type1 Inactive DFGin 7.372 15.546 BLAminus -147.42, 179.7 52.21, 60.23 -77.56, 28.73 281.63, 90.36 -71.43, -13.64 in-in in 8.034 Saltbr-in 3.239 HRD-out -86.98, 107.75 -88.22, 168.06 in-in-out SNCiio in-out ActLoopNT-in 2.894 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -126.76, -4.83 APE9-dihe-na -127.6, 153.97 APE8-dihe-in -68.53, 144.26 APE8-rot-out 182.45 APE67-dihe-in -60.96, -31.45 -55.15, -40.88 APE12-dist-in 12.523 APE11-dist-in 11.316 APE10-dist-in 6.957 APE9-dist-out 6.042 K965R TPO893 TPO893 XRAY 3.41 0.201 0.223 E 344 313 0 0 0 0 [[727, 1020]] 1.0 8bup CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUQB 715 1039 1490.0 RQ9:61101 Type1 Inactive DFGin 6.913 15.301 BLAminus -151.69, -179.79 53.5, 72.83 -94.44, 24.81 291.0, 75.32 -66.25, -27.07 in-in in 8.272 Saltbr-in 3.302 HRD-in -68.63, -54.73 77.99, 1.83 in-in-out SNCiio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.29, -38.77 APE9-dihe-na -81.13, 155.19 APE8-dihe-in -64.33, 147.28 APE8-rot-out 195.9 APE67-dihe-in -60.12, -28.17 -56.8, -43.77 APE12-dist-in 13.559 APE11-dist-in 12.004 APE10-dist-in 6.43 APE9-dist-in 3.506 K965R TPO893 TPO893 XRAY 3.2 0.196 0.216 B 344 321 4 0 0 0 [[727, 1020]] 1.0 8buq CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUQE 715 1027 1490.0 RQ9:61101 Type1 Inactive DFGin 7.362 15.341 BLAminus -149.68, 178.7 52.88, 71.39 -93.43, 23.22 287.54, 76.39 -69.29, -26.75 in-in in 8.145 Saltbr-in 3.15 HRD-in -69.4, -56.77 77.16, 3.04 in-in-out SNCiio in-out ActLoopNT-in 3.016 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -114.18, -38.9 APE9-dihe-na -82.51, 153.34 APE8-dihe-in -63.97, 150.36 APE8-rot-out 173.3 APE67-dihe-in -60.97, -26.14 -55.24, -44.87 APE12-dist-in 13.192 APE11-dist-in 12.463 APE10-dist-in 6.936 APE9-dist-in 3.336 K965R TPO893 TPO893 XRAY 3.2 0.196 0.216 E 344 313 0 0 0 0 [[727, 1020]] 1.0 8buq CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BURB 715 1044 1490.0 RQU:61101 Type1 Inactive DFGin 7.013 15.984 BLAminus -143.02, -172.66 43.3, 72.03 -94.19, 20.72 281.71, 86.88 -65.05, -33.85 in-in in 8.311 Saltbr-in 3.336 HRD-in -64.7, -53.19 72.64, 8.15 in-in-out SNCiio in-out ActLoopNT-in 2.971 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -98.84, -39.21 APE9-dihe-na -79.75, 149.9 APE8-dihe-in -61.25, 143.48 APE8-rot-out 176.27 APE67-dihe-in -64.0, -30.04 -50.29, -42.66 APE12-dist-in 13.218 APE11-dist-in 12.765 APE10-dist-in 7.159 APE9-dist-in 3.447 K965R TPO893 TPO893 XRAY 3.64 0.192 0.234 B 344 330 0 0 0 0 [[727, 1020]] 1.0 8bur CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUSB 715 1039 1490.0 RMX:1101 Type1 Inactive DFGin 7.077 15.719 BLAminus -138.42, 166.28 73.44, 73.47 -93.1, 22.82 287.17, 80.09 -62.57, -33.79 in-in in 8.507 Saltbr-in 3.315 HRD-in -69.35, -51.21 75.34, 13.48 in-in-out SNCiio in-out ActLoopNT-in 3.02 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -86.75, -38.52 APE9-dihe-na -91.11, 154.59 APE8-dihe-in -64.35, 150.44 APE8-rot-out 197.48 APE67-dihe-in -56.11, -29.02 -59.98, -43.72 APE12-dist-in 12.99 APE11-dist-in 12.559 APE10-dist-in 6.978 APE9-dist-in 3.871 K965R TPO893 TPO893 XRAY 3.26 0.209 0.228 B 344 325 0 0 0 0 [[727, 1020]] 1.0 8bus CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUTE 715 1039 1490.0 RQ5:61101 Type1 Inactive DFGin 7.298 15.323 BLAminus -139.51, -178.35 41.51, 85.24 -101.61, 29.69 285.9, 80.14 -70.78, -30.56 in-in in 8.259 Saltbr-in 3.086 HRD-in -67.79, -50.31 72.32, 0.48 in-in-out SNCiio in-out ActLoopNT-in 2.93 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -100.83, -40.87 APE9-dihe-na -77.17, 152.92 APE8-dihe-in -63.05, 147.04 APE8-rot-out 167.97 APE67-dihe-in -65.55, -27.52 -54.27, -41.89 APE12-dist-in 12.932 APE11-dist-in 12.598 APE10-dist-in 6.808 APE9-dist-in 3.452 K965R TPO893 TPO893 XRAY 3.25 0.198 0.217 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8but CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
6CKXA 722 1024 1490.0 8M1:1102 Type1 Inactive DFGin 7.032 14.821 BLAminus -136.28, -177.03 50.17, 81.66 -95.72, 28.97 286.79, 82.51 -69.6, -12.29 in-in in 8.977 Saltbr-in 3.084 HRD-in -75.68, -51.15 65.95, 11.38 in-in-out SNCiio in-out ActLoopNT-in 3.122 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -144.15, 162.82 APE9-dihe-na 64.99, 132.37 APE8-dihe-in -65.8, 148.5 APE8-rot-out 58.87 APE67-dihe-in -65.02, -18.1 -33.35, -57.74 APE12-dist-in 13.141 APE11-dist-in 11.06 APE10-dist-in 6.875 APE9-dist-in 3.495 None TPO893 TPO893 XRAY 2.8 0.21 0.251 A 351 293 10 0 0 0 [[727, 1020]] 1.0 6ckx CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
6CKXC 722 1024 1490.0 8M1:1102 Type1 Inactive DFGin 6.986 14.758 BLAminus -135.84, -177.96 50.19, 82.31 -95.98, 27.29 286.66, 82.56 -71.33, -10.74 in-in in 8.982 Saltbr-in 3.064 HRD-in -76.42, -51.05 66.38, 11.81 in-in-out SNCiio in-out ActLoopNT-in 3.093 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -143.35, 161.59 APE9-dihe-na 66.9, 134.68 APE8-dihe-in -66.86, 147.72 APE8-rot-out 60.13 APE67-dihe-in -63.67, -17.47 -33.52, -58.49 APE12-dist-in 13.151 APE11-dist-in 11.188 APE10-dist-in 6.93 APE9-dist-in 3.524 None TPO893 TPO893 XRAY 2.8 0.21 0.251 C 351 293 10 0 0 0 [[727, 1020]] 1.0 6ckx CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
7NXKC 717 1040 1490.0 UUB:2000 Type1 Inactive DFGin 7.239 15.362 BLAminus -141.93, -168.1 55.29, 66.48 -89.47, 23.2 285.63, 87.42 -65.95, -22.63 in-none in 9.164 Saltbr-none 999.0 HRD-in -59.09, -64.11 84.9, -5.29 none-in-out SNCnio in-out ActLoopNT-in 3.1 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.36, -24.98 APE9-dihe-na -111.23, 152.03 APE8-dihe-in -58.18, 144.58 APE8-rot-out 41.59 APE67-dihe-in -69.39, -10.03 -63.92, -28.51 APE12-dist-in 13.02 APE11-dist-in 11.29 APE10-dist-in 6.468 APE9-dist-in 3.467 None TPO893 TPO893 XRAY 3.0 0.222 0.264 C 351 314 10 0 0 0 [[727, 1020]] 1.0 7nxk CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUGH 715 1039 1490.0 No_ligand No_ligand Inactive DFGin 6.896 15.598 None -126.85, -81.65 -69.29, 99.31 -95.06, 17.81 283.55, 80.77 -62.15, -37.73 in-out in 8.498 Saltbr-out 4.239 HRD-in -64.31, -53.09 70.58, 6.39 out-in-out SNCoio in-out ActLoopNT-in 3.082 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -77.05, -49.38 APE9-dihe-na -69.37, 152.54 APE8-dihe-in -59.34, 145.1 APE8-rot-out 62.3 APE67-dihe-in -62.01, -33.03 -53.97, -44.11 APE12-dist-in 12.973 APE11-dist-in 12.483 APE10-dist-in 6.588 APE9-dist-in 3.652 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 H 344 325 0 0 0 0 [[727, 1020]] 1.0 8bug CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU1B 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 6.888 15.298 None -128.47, -62.59 -80.73, 98.22 -97.65, 30.1 286.08, 74.34 -69.36, -27.39 in-in in 7.821 Saltbr-in 3.264 HRD-in -79.79, -51.42 72.8, -1.21 in-in-out SNCiio in-out ActLoopNT-in 2.713 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.4, -55.58 APE9-dihe-na -85.22, 150.62 APE8-dihe-in -62.26, 144.21 APE8-rot-out 179.44 APE67-dihe-in -65.72, -30.15 -51.5, -38.4 APE12-dist-in 13.282 APE11-dist-in 11.616 APE10-dist-in 6.901 APE9-dist-in 3.714 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 B 344 330 0 0 0 0 [[727, 1020]] 1.0 8bu1 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU1H 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 6.987 15.403 None -124.14, -66.45 -82.78, 98.54 -96.09, 28.76 284.79, 71.99 -70.28, -26.46 in-in in 7.866 Saltbr-in 3.166 HRD-in -79.63, -53.16 73.52, -1.03 in-in-out SNCiio in-out ActLoopNT-in 2.759 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.57, -50.83 APE9-dihe-na -86.52, 154.66 APE8-dihe-in -59.58, 143.86 APE8-rot-out 8.75 APE67-dihe-in -65.52, -30.46 -51.58, -39.94 APE12-dist-in 13.809 APE11-dist-in 12.214 APE10-dist-in 7.236 APE9-dist-in 3.595 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 H 344 330 0 0 0 0 [[727, 1020]] 1.0 8bu1 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU2B 715 1041 1490.0 RVQ:61101 Type1 Inactive DFGin 6.981 15.316 None -126.39, -67.8 -89.47, 99.61 -92.58, 32.18 287.62, 78.29 -74.11, -9.98 in-in in 7.762 Saltbr-in 3.494 HRD-in -72.7, -49.44 72.16, 4.81 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.12, -45.69 APE9-dihe-na -96.32, 148.59 APE8-dihe-in -57.39, 143.59 APE8-rot-in 288.86 APE67-dihe-in -63.0, -36.42 -47.95, -40.21 APE12-dist-in 13.536 APE11-dist-in 11.73 APE10-dist-in 7.073 APE9-dist-in 3.726 K965R TPO893 TPO893 XRAY 3.13 0.193 0.217 B 344 327 0 0 0 0 [[727, 1020]] 1.0 8bu2 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU3B 715 1040 1490.0 RSI:1101 Type1 Inactive DFGin 6.849 15.359 None -135.97, -63.81 -78.62, 93.23 -91.89, 22.93 285.59, 76.13 -60.89, -23.4 in-in in 7.993 Saltbr-in 2.817 HRD-in -67.65, -55.64 77.98, -1.58 in-in-in SNCiii in-in ActLoopNT-in 3.052 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.96, -44.7 APE9-dihe-na -101.31, 148.75 APE8-dihe-in -59.73, 145.03 APE8-rot-in 305.94 APE67-dihe-in -60.6, -36.33 -55.27, -39.92 APE12-dist-in 13.312 APE11-dist-in 11.542 APE10-dist-in 7.049 APE9-dist-in 3.383 K965R TPO893 TPO893 XRAY 3.42 0.187 0.213 B 344 326 0 0 0 0 [[727, 1020]] 1.0 8bu3 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU3H 715 1044 1490.0 RSI:1101 Type1 Inactive DFGin 6.976 15.465 None -130.35, -57.76 -91.85, 92.73 -91.21, 19.54 285.51, 78.88 -63.9, -27.23 in-in in 8.132 Saltbr-in 3.281 HRD-in -66.37, -58.1 77.05, -1.53 in-in-out SNCiio in-out ActLoopNT-in 3.018 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.62, -44.32 APE9-dihe-na -91.3, 148.63 APE8-dihe-in -63.87, 147.34 APE8-rot-out 172.41 APE67-dihe-in -60.12, -36.58 -54.35, -41.92 APE12-dist-in 13.714 APE11-dist-in 11.852 APE10-dist-in 6.818 APE9-dist-in 3.361 K965R TPO893 TPO893 XRAY 3.42 0.187 0.213 H 344 330 0 0 0 0 [[727, 1020]] 1.0 8bu3 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU5E 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 6.942 15.122 None -123.64, -63.66 -81.97, -51.09 56.28, 22.54 292.49, 98.9 -91.33, -28.22 in-out in 8.371 Saltbr-out 3.622 HRD-in -72.77, -54.57 74.45, -4.91 out-in-out SNCoio in-out ActLoopNT-in 2.759 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -134.16, -27.33 APE9-dihe-na -98.05, 157.33 APE8-dihe-in -51.55, 136.25 APE8-rot-in 308.17 APE67-dihe-in -63.16, -26.85 -49.17, -41.17 APE12-dist-out 14.125 APE11-dist-in 12.168 APE10-dist-in 7.286 APE9-dist-in 3.726 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 E 344 331 0 0 0 0 [[727, 1020]] 1.0 8bu5 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU6B 715 1039 1490.0 RQE:61101 Type1 Inactive DFGin 6.977 15.009 None -127.82, -64.26 -87.77, 91.87 -89.24, 20.45 288.89, 72.08 -65.57, -40.39 in-in in 8.424 Saltbr-in 3.481 HRD-in -70.61, -57.84 77.83, -2.42 in-in-out SNCiio in-out ActLoopNT-in 3.122 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.14, -54.56 APE9-dihe-na -81.61, 149.37 APE8-dihe-in -53.79, 145.32 APE8-rot-out 74.18 APE67-dihe-in -56.42, -37.71 -55.03, -39.62 APE12-dist-in 13.927 APE11-dist-in 11.784 APE10-dist-in 6.969 APE9-dist-in 3.408 K965R TPO893 TPO893 XRAY 3.45 0.219 0.249 B 344 325 0 0 0 0 [[727, 1020]] 1.0 8bu6 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU6H 715 1038 1490.0 RQE:61101 Type1 Inactive DFGin 6.859 15.228 None -123.73, -80.29 -80.87, 99.66 -87.02, 20.65 285.61, 58.62 -65.39, -44.16 in-out in 8.422 Saltbr-out 5.096 HRD-in -73.68, -57.19 78.4, -0.7 out-in-out SNCoio in-out ActLoopNT-in 3.086 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.54, -53.3 APE9-dihe-na -74.55, 153.16 APE8-dihe-in -53.11, 139.67 APE8-rot-out 166.86 APE67-dihe-in -53.97, -35.01 -57.57, -41.34 APE12-dist-in 13.136 APE11-dist-in 12.428 APE10-dist-in 7.02 APE9-dist-in 3.421 K965R TPO893 TPO893 XRAY 3.45 0.219 0.249 H 344 324 0 0 0 0 [[727, 1020]] 1.0 8bu6 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BU9B 715 1039 1490.0 RRC:61101 Type1 Inactive DFGin 6.895 15.55 None -126.5, -98.68 -52.95, 118.93 -112.03, 20.69 280.85, 78.53 -65.13, -14.55 in-in in 8.033 Saltbr-in 3.462 HRD-in -71.08, -52.06 74.5, 2.49 in-in-out SNCiio in-out ActLoopNT-in 3.038 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.03, -51.01 APE9-dihe-na -76.4, 148.49 APE8-dihe-in -61.77, 145.89 APE8-rot-out 190.86 APE67-dihe-in -62.1, -33.32 -50.51, -38.53 APE12-dist-in 13.262 APE11-dist-in 11.785 APE10-dist-in 6.5 APE9-dist-in 3.578 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 B 344 325 0 0 0 0 [[727, 1020]] 1.0 8bu9 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUBH 715 1044 1490.0 RNU:61102 Type1 Inactive DFGin 7.264 15.677 None -126.03, -25.89 -87.61, 72.88 -91.51, 12.82 280.63, 73.67 -60.75, -39.82 in-in in 8.482 Saltbr-in 3.553 HRD-out -79.78, 93.25 -67.97, -38.17 in-out-out SNCioo out-out ActLoopNT-out 3.72 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iiii APE10-dihe-na -109.56, -9.94 APE9-dihe-na -106.55, 22.31 APE8-dihe-out 64.82, 23.4 APE8-rot-out 71.99 APE67-dihe-out -104.68, -30.69 71.46, -1.72 APE12-dist-in 12.711 APE11-dist-in 12.093 APE10-dist-in 6.861 APE9-dist-in 4.598 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 H 344 330 0 0 0 0 [[727, 1020]] 1.0 8bub CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUCH 715 1044 1490.0 RKO:61101 Type1 Inactive DFGin 6.938 15.242 None -126.85, -64.01 -88.43, 98.06 -96.23, 24.88 287.21, 69.27 -75.34, -9.66 in-in in 7.946 Saltbr-in 3.3 HRD-in -84.47, -51.91 75.61, -7.74 in-in-in SNCiii in-in ActLoopNT-in 2.979 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.44, -52.72 APE9-dihe-na -81.82, 150.47 APE8-dihe-in -58.85, 136.79 APE8-rot-in 300.83 APE67-dihe-in -60.33, -38.14 -49.32, -40.23 APE12-dist-in 13.762 APE11-dist-in 11.782 APE10-dist-in 6.973 APE9-dist-in 3.26 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 H 344 330 0 0 0 0 [[727, 1020]] 1.0 8buc CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUEB 715 1043 1490.0 RVU:61101 Type1 Inactive DFGin 6.876 15.6 None -134.01, -59.19 -81.95, 94.22 -92.57, 38.59 286.02, 76.0 -80.72, -24.77 in-in in 7.932 Saltbr-in 2.987 HRD-in -72.56, -56.91 77.87, 2.52 in-in-out SNCiio in-out ActLoopNT-in 2.904 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.91, -27.24 APE9-dihe-na -111.61, 155.18 APE8-dihe-in -59.11, 144.49 APE8-rot-out 174.63 APE67-dihe-in -64.14, -33.78 -56.66, -36.69 APE12-dist-in 13.229 APE11-dist-in 11.575 APE10-dist-in 6.84 APE9-dist-in 3.733 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 B 344 329 0 0 0 0 [[727, 1020]] 1.0 8bue CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUFB 715 1033 1490.0 RW6:61101 Type1 Inactive DFGin 6.905 15.636 None -129.93, -62.21 -79.23, 97.53 -95.7, 37.47 286.05, 76.01 -76.9, -21.74 in-in in 8.105 Saltbr-in 3.153 HRD-in -72.11, -52.31 75.51, 2.58 in-in-out SNCiio in-out ActLoopNT-in 2.886 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.68, -63.24 APE9-dihe-na -77.98, 146.57 APE8-dihe-in -61.93, 149.44 APE8-rot-out 186.78 APE67-dihe-in -61.63, -31.53 -53.67, -39.8 APE12-dist-in 13.17 APE11-dist-in 10.994 APE10-dist-in 6.59 APE9-dist-in 3.55 K965R TPO893 TPO893 XRAY 3.3 0.185 0.22 B 344 319 0 0 0 0 [[727, 1020]] 1.0 8buf CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUFH 715 1032 1490.0 RW6:61101 Type1 Inactive DFGin 7.117 15.505 None -129.62, -58.72 -84.56, 91.07 -93.16, 33.34 286.36, 76.3 -77.96, -20.03 in-out in 8.147 Saltbr-out 3.733 HRD-in -74.59, -54.27 72.47, 1.47 out-in-in SNCoii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.36, -62.78 APE9-dihe-na -81.18, 153.72 APE8-dihe-in -60.4, 148.16 APE8-rot-in 306.45 APE67-dihe-in -63.34, -32.17 -56.22, -41.31 APE12-dist-in 13.717 APE11-dist-in 11.792 APE10-dist-in 7.061 APE9-dist-in 3.378 K965R TPO893 TPO893 XRAY 3.3 0.185 0.22 H 344 318 0 0 0 0 [[727, 1020]] 1.0 8buf CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUGB 715 1041 1490.0 RPW:61101 Type1 Inactive DFGin 6.885 15.532 None -132.35, -51.84 -89.28, 88.82 -91.59, 19.28 282.49, 80.64 -62.07, -38.03 in-in in 8.034 Saltbr-in 2.912 HRD-in -62.84, -54.31 70.37, 7.41 in-in-out SNCiio in-out ActLoopNT-in 3.001 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -68.25, -47.63 APE9-dihe-na -75.15, 151.02 APE8-dihe-in -63.11, 148.71 APE8-rot-out 182.54 APE67-dihe-in -62.59, -33.17 -53.62, -43.42 APE12-dist-in 12.503 APE11-dist-in 11.813 APE10-dist-in 6.379 APE9-dist-in 3.619 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 B 344 327 0 0 0 0 [[727, 1020]] 1.0 8bug CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUHB 715 1039 1490.0 RR9:61101 Type1 Inactive DFGin 7.179 15.539 None -138.13, -51.2 -84.38, 89.05 -94.33, 22.38 291.72, 70.83 -65.07, -27.18 in-in in 8.156 Saltbr-in 3.17 HRD-in -65.3, -52.38 69.31, 6.78 in-in-out SNCiio in-out ActLoopNT-in 2.918 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -73.08, -42.42 APE9-dihe-na -75.03, 155.7 APE8-dihe-in -68.77, 151.86 APE8-rot-out 184.25 APE67-dihe-in -61.51, -37.69 -56.24, -40.88 APE12-dist-in 12.3 APE11-dist-in 11.985 APE10-dist-in 6.197 APE9-dist-in 3.673 K965R TPO893 TPO893 XRAY 3.79 0.189 0.232 B 344 325 0 0 0 0 [[727, 1020]] 1.0 8buh CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUHH 715 1033 1490.0 RR9:61101 Type1 Inactive DFGin 6.887 15.22 None -138.17, -50.63 -86.02, 83.59 -88.15, 19.63 292.55, 71.89 -63.06, -22.61 in-in in 8.184 Saltbr-in 2.943 HRD-in -66.24, -47.16 69.47, -1.27 in-in-out SNCiio in-out ActLoopNT-in 3.045 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -73.8, -40.23 APE9-dihe-na -75.94, 158.01 APE8-dihe-in -67.45, 146.95 APE8-rot-out 179.42 APE67-dihe-in -59.63, -39.48 -58.91, -41.72 APE12-dist-in 13.23 APE11-dist-in 12.468 APE10-dist-in 6.767 APE9-dist-in 3.376 K965R TPO893 TPO893 XRAY 3.79 0.189 0.232 H 344 319 0 0 0 0 [[727, 1020]] 1.0 8buh CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUJB 715 1041 1490.0 RUW:1101 Type1 Inactive DFGin 6.983 15.2 None -129.99, -57.9 -94.94, 86.34 -84.73, 29.33 287.08, 75.1 -66.06, -25.85 in-in in 7.864 Saltbr-in 2.946 HRD-in -63.86, -54.33 75.41, -2.11 in-in-out SNCiio in-out ActLoopNT-in 3.063 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -117.09, -50.74 APE9-dihe-na -90.83, 154.53 APE8-dihe-in -64.5, 148.14 APE8-rot-out 189.98 APE67-dihe-in -60.8, -34.01 -57.18, -38.53 APE12-dist-in 13.262 APE11-dist-in 11.425 APE10-dist-in 7.106 APE9-dist-in 3.522 K965R TPO893 TPO893 XRAY 3.62 0.164 0.206 B 344 327 0 0 0 0 [[727, 1020]] 1.0 8buj CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUJH 715 1043 1490.0 RUW:1101 Type1 Inactive DFGin 6.896 15.077 None -125.46, -61.45 -96.84, 87.36 -85.01, 26.05 287.54, 74.01 -66.36, -25.41 in-in in 7.813 Saltbr-in 3.01 HRD-in -63.78, -55.47 74.76, -1.95 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.8, -48.82 APE9-dihe-na -90.4, 155.44 APE8-dihe-in -63.14, 147.75 APE8-rot-in 306.89 APE67-dihe-in -59.19, -33.71 -59.17, -40.93 APE12-dist-in 13.546 APE11-dist-in 11.437 APE10-dist-in 6.901 APE9-dist-in 3.454 K965R TPO893 TPO893 XRAY 3.62 0.164 0.206 H 344 329 0 0 0 0 [[727, 1020]] 1.0 8buj CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUKB 715 1040 1490.0 RWE:61101 Type1 Inactive DFGin 6.868 15.185 None -136.79, -63.9 -86.16, 95.92 -96.18, 34.75 292.05, 70.82 -73.05, -21.93 in-in in 7.997 Saltbr-in 2.896 HRD-in -70.18, -56.12 75.44, 6.36 in-in-in SNCiii in-in ActLoopNT-in 2.951 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.1, -51.8 APE9-dihe-na -97.16, 156.72 APE8-dihe-in -60.0, 144.72 APE8-rot-in 296.0 APE67-dihe-in -62.91, -30.64 -55.4, -37.75 APE12-dist-in 13.344 APE11-dist-in 11.495 APE10-dist-in 7.221 APE9-dist-in 3.634 K965R TPO893 TPO893 XRAY 3.41 0.186 0.21 B 344 326 0 0 0 0 [[727, 1020]] 1.0 8buk CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUKH 715 1044 1490.0 RWE:61101 Type1 Inactive DFGin 6.839 15.247 None -132.41, -70.3 -85.48, 98.43 -94.85, 32.62 289.18, 70.32 -75.66, -23.83 in-in in 8.084 Saltbr-in 3.087 HRD-in -67.86, -57.14 74.14, 6.98 in-in-out SNCiio in-out ActLoopNT-in 2.886 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -102.71, -45.22 APE9-dihe-na -97.3, 156.39 APE8-dihe-in -62.45, 146.81 APE8-rot-out 169.98 APE67-dihe-in -63.55, -31.48 -56.16, -39.65 APE12-dist-in 13.689 APE11-dist-in 11.797 APE10-dist-in 7.13 APE9-dist-in 3.728 K965R TPO893 TPO893 XRAY 3.41 0.186 0.21 H 344 330 0 0 0 0 [[727, 1020]] 1.0 8buk CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BULB 715 1039 1490.0 RSU:1101 Type1 Inactive DFGin 7.048 15.572 None -134.15, -61.62 -82.15, 93.36 -91.03, 19.31 284.15, 82.25 -57.36, -30.14 in-in in 7.938 Saltbr-in 2.929 HRD-in -70.64, -53.34 75.97, 4.36 in-in-in SNCiii in-in ActLoopNT-in 3.117 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.1, -23.33 APE9-dihe-na -106.91, 152.49 APE8-dihe-in -59.59, 141.04 APE8-rot-in 301.22 APE67-dihe-in -61.09, -37.16 -52.97, -42.84 APE12-dist-in 13.298 APE11-dist-in 11.607 APE10-dist-in 6.723 APE9-dist-in 3.608 None TPO893 TPO893 XRAY 3.4 0.179 0.215 B 344 325 0 0 0 0 [[727, 1020]] 1.0 8bul CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUMB 715 1040 1490.0 T6X:1101 Type1 Inactive DFGin 6.864 15.665 None -134.73, -83.5 -67.29, 93.27 -90.11, 26.53 284.48, 75.06 -65.26, -28.59 in-in in 7.994 Saltbr-in 3.485 HRD-in -65.89, -56.24 77.66, 6.87 in-in-in SNCiii in-in ActLoopNT-in 3.127 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.13, -38.62 APE9-dihe-na -95.11, 154.79 APE8-dihe-in -60.97, 148.11 APE8-rot-in 309.8 APE67-dihe-in -61.69, -36.7 -58.55, -38.83 APE12-dist-in 13.456 APE11-dist-in 11.598 APE10-dist-in 6.67 APE9-dist-in 3.667 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 B 344 326 0 0 0 0 [[727, 1020]] 1.0 8bum CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUMH 715 1039 1490.0 T6X:1101 Type1 Inactive DFGin 7.024 15.457 None -135.37, -57.05 -84.79, 89.46 -91.01, 22.09 287.95, 72.46 -66.77, -30.21 in-out in 8.068 Saltbr-out 4.131 HRD-in -66.21, -56.87 75.95, 5.67 out-in-in SNCoii in-in ActLoopNT-in 2.955 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.45, -40.59 APE9-dihe-na -95.46, 155.5 APE8-dihe-in -61.11, 150.0 APE8-rot-in 312.75 APE67-dihe-in -61.06, -36.71 -56.48, -41.62 APE12-dist-in 13.625 APE11-dist-in 11.736 APE10-dist-in 7.168 APE9-dist-in 3.579 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 H 344 325 0 0 0 0 [[727, 1020]] 1.0 8bum CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUOH 715 1044 1490.0 RLC:1101 Type1 Inactive DFGin 6.953 15.267 None -133.0, -52.84 -89.06, 92.6 -92.03, 19.54 286.01, 76.31 -65.14, -29.67 in-in in 8.196 Saltbr-in 3.289 HRD-in -68.8, -55.72 77.31, -13.16 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.5, -30.39 APE9-dihe-na -96.1, 151.94 APE8-dihe-in -61.51, 140.45 APE8-rot-in 333.9 APE67-dihe-in -58.03, -34.02 -53.9, -41.38 APE12-dist-in 13.549 APE11-dist-in 11.791 APE10-dist-in 6.766 APE9-dist-in 3.358 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 H 344 330 0 0 0 0 [[727, 1020]] 1.0 8buo CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUQH 715 1035 1490.0 RQ9:61101 Type1 Inactive DFGin 6.847 15.413 None -139.0, -68.9 -74.65, 86.14 -87.77, 25.62 285.6, 75.05 -68.98, -27.88 in-in in 8.141 Saltbr-in 3.342 HRD-in -71.56, -55.82 75.32, -0.25 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.77, -46.85 APE9-dihe-na -88.37, 155.15 APE8-dihe-in -63.62, 147.91 APE8-rot-out 74.55 APE67-dihe-in -59.91, -28.34 -56.29, -43.5 APE12-dist-in 13.706 APE11-dist-in 11.98 APE10-dist-in 7.059 APE9-dist-in 3.543 K965R TPO893 TPO893 XRAY 3.2 0.196 0.216 H 344 321 0 0 0 0 [[727, 1020]] 1.0 8buq CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BURH 715 1039 1490.0 RQU:61101 Type1 Inactive DFGin 6.774 15.444 None -128.98, -68.65 -83.3, 94.14 -94.27, 19.71 289.32, 85.87 -66.64, -31.92 in-in in 8.145 Saltbr-in 2.879 HRD-in -62.95, -51.76 69.51, 6.54 in-in-out SNCiio in-out ActLoopNT-in 3.108 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -119.35, -54.64 APE9-dihe-na -87.35, 151.65 APE8-dihe-in -60.57, 144.24 APE8-rot-out 76.95 APE67-dihe-in -62.32, -33.37 -50.2, -40.95 APE12-dist-in 13.743 APE11-dist-in 11.662 APE10-dist-in 7.086 APE9-dist-in 3.671 K965R TPO893 TPO893 XRAY 3.64 0.192 0.234 H 344 325 0 0 0 0 [[727, 1020]] 1.0 8bur CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
8BUSE 715 1043 1490.0 RMX:1101 Type1 Inactive DFGin 6.726 15.869 None -132.84, -50.43 -84.41, 82.25 -87.45, 22.35 281.7, 77.83 -63.73, -33.79 in-in in 8.158 Saltbr-in 3.282 HRD-in -70.71, -48.94 71.36, 12.53 in-in-out SNCiio in-out ActLoopNT-in 2.996 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -96.11, -47.21 APE9-dihe-na -97.32, 150.19 APE8-dihe-in -67.32, 151.1 APE8-rot-out 195.8 APE67-dihe-in -58.67, -27.66 -56.54, -42.34 APE12-dist-in 13.285 APE11-dist-in 11.393 APE10-dist-in 7.34 APE9-dist-in 3.456 K965R TPO893 TPO893 XRAY 3.26 0.209 0.228 E 344 329 0 0 0 0 [[727, 1020]] 1.0 8bus CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
9FMRB 714 1047 1490.0 RMF:61101 Type1 Inactive DFGin 7.124 15.031 None -111.49, -74.26 -77.99, -72.15 68.85, 12.84 296.16, 89.8 -66.22, -36.51 in-out in 8.332 Saltbr-out 4.45 HRD-in -70.8, -35.56 62.81, 1.22 out-in-in SNCoii in-in ActLoopNT-in 3.072 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.03, -25.75 APE9-dihe-na -103.56, 146.88 APE8-dihe-in -51.72, 138.27 APE8-rot-in 305.58 APE67-dihe-in -69.51, -21.36 -53.61, -35.19 APE12-dist-in 13.987 APE11-dist-in 12.27 APE10-dist-in 7.331 APE9-dist-in 3.865 None TPO893 TPO893 XRAY 3.9 0.209 0.25 B 351 334 0 0 0 0 [[727, 1020]] 1.0 9fmr CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

CMGC_CDK12 (Cyclin-dependent kinase 12)

Total number of chains: 109
Active chains: 10
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 53 48.6% AF-Q9NYV4-K1A
DFGin None 30 27.5% 8BU1B
DFGin ABAminus 26 23.9% 8BUNB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK12_HUMAN AF-Q9NYV4-K1A Q9NYV4 719 1028 1490.0 No_ligand No_ligand Active DFGin 6.742 15.021 BLAminus -135.31, 176.11 57.83, 65.7 -78.9, 19.02 283.91, 75.49 -59.53, -34.42 in-in in 8.848 Saltbr-in 2.872 HRD-in -74.38, -50.97 65.06, 11.96 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.35, 171.85 APE9-dihe-na 62.69, 132.06 APE8-dihe-in -56.47, 137.03 APE8-rot-in 300.21 APE67-dihe-in -68.24, -22.81 -49.07, -40.83 APE12-dist-in 13.067 APE11-dist-in 11.195 APE10-dist-in 6.634 APE9-dist-in 3.345 None None None AF2 -1.0 1.0 1.0 A 310 310 0 0 0 0 [[727, 1020]] 1.0 AF-Q9NYV4-K1 Homo sapiens CMGC_CDK12_HUMAN CMGC 1.8e-84 289.4 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN AF-Q9NYV4-K3A Q9NYV4 719 1028 1490.0 No_ligand No_ligand Active DFGin 6.943 15.648 BLAminus -131.2, -179.25 62.41, 52.03 -71.34, 9.91 284.98, 77.79 -61.92, -24.64 in-in in 8.449 Saltbr-in 3.026 HRD-in -78.33, -50.25 65.94, 8.6 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.81, 169.8 APE9-dihe-na 61.73, 134.8 APE8-dihe-in -58.63, 136.64 APE8-rot-in 295.26 APE67-dihe-in -64.98, -27.17 -49.82, -42.02 APE12-dist-in 13.481 APE11-dist-in 11.609 APE10-dist-in 7.174 APE9-dist-in 3.21 None None None AF2 -1.0 1.0 1.0 A 310 310 0 0 0 0 [[727, 1020]] 1.0 AF-Q9NYV4-K3 Homo sapiens CMGC_CDK12_HUMAN CMGC 1.8e-84 289.4 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU7B Q9NYV4 715 1043 1490.0 No_ligand No_ligand Active DFGin 7.077 15.544 BLAminus -153.2, -179.33 57.0, 56.86 -76.66, 35.76 288.9, 72.8 -62.53, -36.58 in-in in 7.944 Saltbr-in 2.97 HRD-in -65.11, -49.8 70.58, 2.94 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.3, -42.09 APE9-dihe-na -92.76, 146.08 APE8-dihe-in -61.7, 141.25 APE8-rot-in 286.85 APE67-dihe-in -64.16, -31.94 -48.15, -39.73 APE12-dist-in 12.796 APE11-dist-in 11.304 APE10-dist-in 6.44 APE9-dist-in 3.723 K965R TPO893 TPO893 XRAY 3.245 0.193 0.219 B 344 329 0 0 0 0 [[727, 1020]] 1.0 8bu7 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU7H Q9NYV4 715 1043 1490.0 No_ligand No_ligand Active DFGin 6.925 15.216 BLAminus -150.49, -178.12 60.69, 55.85 -80.72, 28.91 286.49, 71.19 -68.37, -37.18 in-in in 7.997 Saltbr-in 3.127 HRD-in -67.99, -49.39 67.61, 1.86 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.1, -50.99 APE9-dihe-na -89.61, 147.06 APE8-dihe-in -59.45, 144.95 APE8-rot-in 311.35 APE67-dihe-in -64.87, -31.1 -48.4, -40.63 APE12-dist-in 13.821 APE11-dist-in 11.638 APE10-dist-in 7.151 APE9-dist-in 3.568 K965R TPO893 TPO893 XRAY 3.245 0.193 0.219 H 344 329 0 0 0 0 [[727, 1020]] 1.0 8bu7 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 6TD3E Q9NYV4 715 1047 1490.0 RC8:1101 Type1 Active DFGin 7.044 15.193 BLAminus -147.32, 173.39 63.76, 65.42 -84.24, 25.56 288.49, 76.82 -64.44, -36.48 in-in in 7.974 Saltbr-in 3.167 HRD-in -75.19, -47.55 67.28, 2.07 in-in-in SNCiii in-in ActLoopNT-in 2.953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -75.91, -39.12 APE9-dihe-na -86.17, 150.74 APE8-dihe-in -63.73, 141.42 APE8-rot-in 305.37 APE67-dihe-in -59.47, -32.88 -40.08, -54.92 APE12-dist-in 13.176 APE11-dist-in 11.902 APE10-dist-in 6.855 APE9-dist-in 3.435 K965R TPO893 TPO893 XRAY 3.46 0.195 0.22 E 344 333 0 0 0 0 [[727, 1020]] 1.0 6td3 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU3E Q9NYV4 715 1039 1490.0 RSI:1101 Type1 Active DFGin 7.141 15.534 BLAminus -142.27, 178.66 43.04, 82.11 -92.94, 21.36 280.44, 78.98 -62.21, -28.8 in-in in 8.118 Saltbr-in 3.049 HRD-in -67.4, -56.47 76.99, -0.73 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.29, 7.21 APE9-dihe-na -139.88, 150.07 APE8-dihe-in -59.05, 143.88 APE8-rot-in 303.03 APE67-dihe-in -61.38, -34.53 -56.72, -42.72 APE12-dist-in 13.107 APE11-dist-in 12.76 APE10-dist-in 7.175 APE9-dist-in 3.446 K965R TPO893 TPO893 XRAY 3.42 0.187 0.213 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bu3 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BULE Q9NYV4 715 1038 1490.0 RSU:1101 Type1 Active DFGin 7.269 15.574 BLAminus -142.23, 173.11 51.26, 74.93 -90.42, 13.84 281.63, 81.18 -57.04, -28.57 in-in in 8.073 Saltbr-in 3.068 HRD-in -70.66, -53.79 75.17, 4.92 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.18, -18.48 APE9-dihe-na -95.24, 149.84 APE8-dihe-in -59.92, 143.14 APE8-rot-in 301.12 APE67-dihe-in -61.61, -35.96 -53.3, -43.95 APE12-dist-in 12.727 APE11-dist-in 12.53 APE10-dist-in 6.687 APE9-dist-in 3.385 None TPO893 TPO893 XRAY 3.4 0.179 0.215 E 344 324 0 0 0 0 [[727, 1020]] 1.0 8bul Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUME Q9NYV4 715 1039 1490.0 T6X:1101 Type1 Active DFGin 7.174 15.484 BLAminus -146.26, -169.41 35.67, 76.14 -91.08, 23.16 287.18, 101.24 -64.43, -27.28 in-in in 8.379 Saltbr-in 3.393 HRD-in -65.58, -57.98 78.09, 6.9 in-in-in SNCiii in-in ActLoopNT-in 3.007 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.86, -32.86 APE9-dihe-na -90.18, 155.36 APE8-dihe-in -60.4, 149.13 APE8-rot-in 310.02 APE67-dihe-in -62.09, -34.98 -57.41, -41.5 APE12-dist-in 12.684 APE11-dist-in 12.102 APE10-dist-in 6.747 APE9-dist-in 3.38 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bum Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUPH Q9NYV4 715 1028 1490.0 RWN:61101 Type1 Active DFGin 7.109 15.406 BLAminus -147.42, -178.11 55.21, 58.82 -78.24, 30.65 278.56, 80.87 -74.41, -18.78 in-in in 8.092 Saltbr-in 3.315 HRD-in -72.38, -49.1 69.31, -11.39 in-in-in SNCiii in-in ActLoopNT-in 3.034 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.08, -16.8 APE9-dihe-na -129.39, 159.74 APE8-dihe-in -65.11, 144.15 APE8-rot-in 304.17 APE67-dihe-in -60.23, -34.65 -53.66, -41.25 APE12-dist-in 13.306 APE11-dist-in 10.977 APE10-dist-in 7.068 APE9-dist-in 3.502 K965R TPO893 TPO893 XRAY 3.41 0.201 0.223 H 344 314 0 0 0 0 [[727, 1020]] 1.0 8bup Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8P81A Q9NYV4 716 1035 1490.0 RMF:1101 Type1 Active DFGin 7.095 14.446 BLAminus -134.83, -178.64 59.2, 72.19 -89.53, 34.88 291.56, 80.44 -67.97, -22.73 in-in in 8.359 Saltbr-in 3.057 HRD-in -81.5, -42.97 59.01, 18.94 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.63, 165.61 APE9-dihe-na 67.08, 139.25 APE8-dihe-in -61.99, 152.33 APE8-rot-in 316.49 APE67-dihe-in -68.12, -20.85 -57.98, -41.98 APE12-dist-in 12.679 APE11-dist-in 10.561 APE10-dist-in 6.52 APE9-dist-in 3.212 None TPO893 TPO893 XRAY 2.68 0.212 0.255 A 351 320 0 0 0 0 [[727, 1020]] 1.0 8p81 Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU2H Q9NYV4 715 1043 1490.0 RVQ:61101 Type1 Inactive DFGin 7.124 15.366 ABAminus -126.78, -38.9 -105.5, 92.35 -91.27, 30.22 285.75, 68.07 -78.32, -11.53 in-in in 7.785 Saltbr-in 3.316 HRD-in -76.93, -54.56 71.73, 6.27 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.54, -42.84 APE9-dihe-na -100.7, 153.79 APE8-dihe-in -58.19, 144.22 APE8-rot-in 306.05 APE67-dihe-in -62.43, -37.08 -51.71, -42.2 APE12-dist-in 13.851 APE11-dist-in 11.936 APE10-dist-in 7.208 APE9-dist-in 3.638 K965R TPO893 TPO893 XRAY 3.13 0.193 0.217 H 344 329 0 0 0 0 [[727, 1020]] 1.0 8bu2 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU4B Q9NYV4 715 1043 1490.0 RQL:61101 Type1 Inactive DFGin 6.85 15.448 ABAminus -129.55, -62.28 -85.09, 103.01 -99.2, 24.51 288.36, 76.72 -66.96, -36.21 in-in in 8.357 Saltbr-in 2.975 HRD-in -68.4, -61.77 77.35, 4.99 in-in-out SNCiio in-out ActLoopNT-in 2.992 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.64, -39.36 APE9-dihe-na -92.3, 149.92 APE8-dihe-in -61.52, 149.36 APE8-rot-out 186.04 APE67-dihe-in -64.54, -31.54 -56.18, -38.32 APE12-dist-in 13.385 APE11-dist-in 11.507 APE10-dist-in 6.611 APE9-dist-in 3.458 K965R TPO893 TPO893 XRAY 3.09 0.205 0.223 B 344 329 0 0 0 0 [[727, 1020]] 1.0 8bu4 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU4H Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 7.047 15.528 ABAminus -118.75, -57.9 -97.23, 97.83 -98.97, 29.55 288.47, 78.73 -75.71, -15.5 in-out in 8.287 Saltbr-out 3.906 HRD-in -79.59, -55.06 74.66, 4.8 out-in-out SNCoio in-out ActLoopNT-in 2.879 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -121.0, -34.01 APE9-dihe-na -98.0, 156.31 APE8-dihe-in -61.54, 149.21 APE8-rot-out 67.45 APE67-dihe-in -64.95, -40.0 -58.15, -33.89 APE12-dist-in 13.822 APE11-dist-in 12.046 APE10-dist-in 7.165 APE9-dist-in 3.551 K965R TPO893 TPO893 XRAY 3.09 0.205 0.223 H 344 330 0 0 0 0 [[727, 1020]] 1.0 8bu4 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU5B Q9NYV4 713 1044 1490.0 RMF:1101 Type1 Inactive DFGin 6.801 14.701 ABAminus -126.95, -66.04 -93.95, 105.24 -102.41, 30.18 293.69, 100.66 -84.84, -22.58 in-out in 8.305 Saltbr-out 3.933 HRD-out -78.59, 106.12 -94.17, 5.74 out-in-out SNCoio in-out ActLoopNT-in 2.828 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -136.91, -22.25 APE9-dihe-na -109.89, 157.52 APE8-dihe-in -56.01, 131.78 APE8-rot-in 308.02 APE67-dihe-in -60.99, -26.61 -52.03, -40.26 APE12-dist-out 14.28 APE11-dist-in 11.941 APE10-dist-in 7.36 APE9-dist-in 3.767 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 B 344 332 0 0 0 0 [[727, 1020]] 1.0 8bu5 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU5H Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 7.015 14.978 ABAminus -128.46, -54.53 -90.71, 103.12 -97.22, 31.8 290.43, 81.59 -85.33, -25.69 in-in in 8.479 Saltbr-in 3.527 HRD-in -73.55, -49.58 63.85, -4.76 in-in-in SNCiii in-in ActLoopNT-in 2.629 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.5, -28.02 APE9-dihe-na -97.36, 153.71 APE8-dihe-in -57.72, 135.61 APE8-rot-in 311.07 APE67-dihe-in -63.38, -27.52 -50.57, -39.59 APE12-dist-in 13.941 APE11-dist-in 12.128 APE10-dist-in 7.258 APE9-dist-in 3.497 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 H 344 331 0 0 0 0 [[727, 1020]] 1.0 8bu5 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU9H Q9NYV4 715 1038 1490.0 RRC:61101 Type1 Inactive DFGin 6.897 15.028 ABAminus -130.72, -61.46 -86.64, 101.77 -100.72, 17.49 288.44, 80.02 -65.69, -13.23 in-in in 8.148 Saltbr-in 3.594 HRD-in -73.34, -52.41 71.89, 3.55 in-in-out SNCiio in-out ActLoopNT-in 2.783 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.4, -56.59 APE9-dihe-na -80.8, 152.68 APE8-dihe-in -61.03, 143.88 APE8-rot-out 47.91 APE67-dihe-in -59.68, -32.23 -55.45, -41.09 APE12-dist-in 13.723 APE11-dist-in 11.944 APE10-dist-in 7.007 APE9-dist-in 3.523 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 H 344 324 0 0 0 0 [[727, 1020]] 1.0 8bu9 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUAB Q9NYV4 715 1039 1490.0 RVH:1101 Type1 Inactive DFGin 6.66 15.37 ABAminus -132.25, -47.59 -83.62, 100.61 -101.79, 23.05 288.11, 77.38 -59.48, -33.33 in-in in 8.072 Saltbr-in 2.933 HRD-in -66.14, -55.51 74.2, 0.02 in-in-in SNCiii in-in ActLoopNT-in 2.958 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.76, -47.66 APE9-dihe-na -82.97, 151.34 APE8-dihe-in -63.64, 142.13 APE8-rot-in 293.22 APE67-dihe-in -60.49, -35.73 -49.76, -42.55 APE12-dist-in 13.568 APE11-dist-in 11.766 APE10-dist-in 6.666 APE9-dist-in 3.543 K965R TPO893 TPO893 XRAY 3.193 0.202 0.225 B 344 325 0 0 0 0 [[727, 1020]] 1.0 8bua Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUAE Q9NYV4 715 1033 1490.0 RVH:1101 Type1 Inactive DFGin 6.957 15.083 ABAminus -126.35, -57.7 -89.06, 99.95 -100.88, 19.34 288.21, 78.03 -60.59, -33.21 in-out in 8.364 Saltbr-out 3.678 HRD-in -67.84, -57.25 75.2, 0.85 out-in-out SNCoio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -70.04, -46.21 APE9-dihe-na -79.96, 152.67 APE8-dihe-in -66.28, 142.61 APE8-rot-out 169.95 APE67-dihe-in -61.55, -33.2 -51.95, -45.85 APE12-dist-in 13.685 APE11-dist-in 12.086 APE10-dist-in 6.766 APE9-dist-in 3.422 K965R TPO893 TPO893 XRAY 3.193 0.202 0.225 E 344 319 0 0 0 0 [[727, 1020]] 1.0 8bua Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUAH Q9NYV4 715 1034 1490.0 RVH:1101 Type1 Inactive DFGin 6.883 15.42 ABAminus -126.04, -56.2 -88.9, 101.16 -97.82, 20.48 283.52, 73.51 -61.26, -31.16 in-in in 7.933 Saltbr-in 2.969 HRD-in -68.56, -58.56 73.11, 1.68 in-in-out SNCiio in-out ActLoopNT-in 2.897 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -115.42, -52.09 APE9-dihe-na -83.64, 155.3 APE8-dihe-in -61.52, 141.11 APE8-rot-in 293.24 APE67-dihe-in -60.38, -38.31 -51.83, -39.97 APE12-dist-out 14.088 APE11-dist-in 12.25 APE10-dist-in 7.273 APE9-dist-in 3.546 K965R TPO893 TPO893 XRAY 3.193 0.202 0.225 H 344 320 0 0 0 0 [[727, 1020]] 1.0 8bua Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUCB Q9NYV4 715 1041 1490.0 RKO:61101 Type1 Inactive DFGin 6.835 15.495 ABAminus -130.47, -49.88 -100.7, 87.88 -87.1, 28.61 287.17, 76.07 -67.87, -32.97 in-in in 8.127 Saltbr-in 2.928 HRD-in -72.49, -52.56 71.47, 1.89 in-in-out SNCiio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.68, -53.4 APE9-dihe-na -81.9, 152.03 APE8-dihe-in -63.34, 145.38 APE8-rot-out 183.29 APE67-dihe-in -65.1, -32.1 -54.44, -34.81 APE12-dist-in 13.234 APE11-dist-in 11.425 APE10-dist-in 6.56 APE9-dist-in 3.613 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 B 344 327 0 0 0 0 [[727, 1020]] 1.0 8buc Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUDB Q9NYV4 715 1043 1490.0 RP9:61101 Type1 Inactive DFGin 6.806 15.424 ABAminus -142.15, -16.91 -106.36, 87.13 -96.45, 32.21 289.44, 76.45 -77.57, -27.46 in-in in 8.02 Saltbr-in 3.49 HRD-in -66.52, -51.15 74.89, 1.88 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.04, -21.52 APE9-dihe-na -109.6, 155.4 APE8-dihe-in -62.09, 142.67 APE8-rot-in 309.35 APE67-dihe-in -60.6, -25.6 -60.57, -39.4 APE12-dist-in 13.191 APE11-dist-in 11.736 APE10-dist-in 6.693 APE9-dist-in 3.695 K965R TPO893 TPO893 XRAY 3.2 0.191 0.22 B 344 329 0 0 0 0 [[727, 1020]] 1.0 8bud Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUDH Q9NYV4 715 1043 1490.0 RP9:61101 Type1 Inactive DFGin 6.946 15.357 ABAminus -136.05, -39.21 -99.68, 89.69 -94.42, 33.08 285.78, 76.86 -80.16, -27.09 in-in in 7.932 Saltbr-in 3.095 HRD-in -68.45, -57.7 74.71, 4.44 in-in-in SNCiii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.74, -26.44 APE9-dihe-na -108.9, 157.16 APE8-dihe-in -60.21, 144.65 APE8-rot-in 297.94 APE67-dihe-in -60.44, -27.56 -58.25, -38.75 APE12-dist-in 13.649 APE11-dist-in 11.734 APE10-dist-in 7.159 APE9-dist-in 3.655 K965R TPO893 TPO893 XRAY 3.2 0.191 0.22 H 344 329 0 0 0 0 [[727, 1020]] 1.0 8bud Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUEH Q9NYV4 715 1043 1490.0 RVU:61101 Type1 Inactive DFGin 6.953 15.528 ABAminus -135.4, -31.77 -104.88, 88.01 -89.97, 37.83 286.95, 75.03 -83.73, -24.85 in-in in 8.095 Saltbr-in 3.053 HRD-in -72.11, -58.45 75.28, 1.16 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.38, -30.92 APE9-dihe-na -101.17, 153.28 APE8-dihe-in -59.63, 146.59 APE8-rot-in 309.03 APE67-dihe-in -63.21, -32.83 -55.37, -40.46 APE12-dist-in 13.521 APE11-dist-in 11.657 APE10-dist-in 6.904 APE9-dist-in 3.35 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 H 344 329 0 0 0 0 [[727, 1020]] 1.0 8bue Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUIB Q9NYV4 715 1041 1490.0 RV6:1101 Type1 Inactive DFGin 6.848 15.385 ABAminus -131.36, -62.29 -89.48, 101.04 -94.93, 20.15 285.65, 74.39 -62.98, -21.99 in-in in 8.063 Saltbr-in 3.244 HRD-out -78.21, 99.43 -82.66, -35.16 in-in-in SNCiii in-in ActLoopNT-in 3.167 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.84, -19.18 APE9-dihe-na -128.33, 156.07 APE8-dihe-in -65.63, 140.55 APE8-rot-in 297.93 APE67-dihe-in -59.87, -34.95 -53.39, -43.04 APE12-dist-in 13.365 APE11-dist-in 10.961 APE10-dist-in 7.253 APE9-dist-in 4.181 K965R TPO893 TPO893 XRAY 3.5 0.184 0.221 B 344 327 0 0 0 0 [[727, 1020]] 1.0 8bui Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUIH Q9NYV4 715 1038 1490.0 RV6:1101 Type1 Inactive DFGin 6.97 15.281 ABAminus -131.92, -50.63 -89.53, 95.29 -98.99, 14.99 287.64, 76.53 -67.14, -30.95 in-in in 8.151 Saltbr-in 3.277 HRD-out -79.19, 77.36 -62.47, -39.48 in-in-in SNCiii in-in ActLoopNT-in 2.993 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.57, -18.14 APE9-dihe-na -112.45, 157.67 APE8-dihe-in -65.3, 140.25 APE8-rot-in 297.23 APE67-dihe-in -58.21, -35.12 -53.14, -43.81 APE12-dist-in 13.665 APE11-dist-in 11.525 APE10-dist-in 7.005 APE9-dist-in 3.874 K965R TPO893 TPO893 XRAY 3.5 0.184 0.221 H 344 324 0 0 0 0 [[727, 1020]] 1.0 8bui Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BULH Q9NYV4 715 1034 1490.0 RSU:1101 Type1 Inactive DFGin 7.002 15.334 ABAminus -135.61, -41.73 -99.52, 91.67 -88.52, 15.79 285.0, 79.41 -60.56, -30.48 in-in in 7.861 Saltbr-in 2.946 HRD-in -71.18, -53.58 72.73, 2.44 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.32, -27.33 APE9-dihe-na -113.19, 154.32 APE8-dihe-in -60.54, 141.61 APE8-rot-in 300.72 APE67-dihe-in -58.89, -38.82 -52.85, -42.63 APE12-dist-in 13.5 APE11-dist-in 11.612 APE10-dist-in 7.182 APE9-dist-in 3.818 None TPO893 TPO893 XRAY 3.4 0.179 0.215 H 344 320 0 0 0 0 [[727, 1020]] 1.0 8bul Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUNB Q9NYV4 715 1041 1490.0 RNF:61101 Type1 Inactive DFGin 7.009 15.297 ABAminus -131.36, -49.43 -89.83, 91.44 -92.44, 32.63 287.3, 77.5 -75.27, -18.22 in-in in 7.748 Saltbr-in 3.279 HRD-in -75.67, -53.71 75.4, -0.11 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.12, -39.12 APE9-dihe-na -104.98, 151.97 APE8-dihe-in -58.93, 142.91 APE8-rot-in 279.94 APE67-dihe-in -65.42, -33.6 -55.06, -35.14 APE12-dist-in 13.388 APE11-dist-in 11.695 APE10-dist-in 7.099 APE9-dist-in 3.657 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 B 344 327 0 0 0 0 [[727, 1020]] 1.0 8bun Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUNH Q9NYV4 715 1043 1490.0 RNF:61101 Type1 Inactive DFGin 7.045 15.286 ABAminus -125.24, -50.09 -100.69, 94.75 -92.24, 30.97 286.18, 71.82 -75.42, -18.26 in-in in 7.834 Saltbr-in 3.373 HRD-in -77.6, -54.36 73.0, -1.25 in-in-in SNCiii in-in ActLoopNT-in 2.74 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.56, -41.65 APE9-dihe-na -95.79, 153.05 APE8-dihe-in -58.87, 144.43 APE8-rot-in 305.25 APE67-dihe-in -65.98, -31.29 -55.83, -37.71 APE12-dist-in 13.775 APE11-dist-in 11.972 APE10-dist-in 6.957 APE9-dist-in 3.478 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 H 344 329 0 0 0 0 [[727, 1020]] 1.0 8bun Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUOB Q9NYV4 715 1040 1490.0 RLC:1101 Type1 Inactive DFGin 6.577 15.644 ABAminus -146.64, 39.95 -136.73, 75.69 -99.12, 16.92 290.75, 79.72 -67.9, -33.68 in-in in 8.213 Saltbr-in 2.831 HRD-in -67.45, -41.41 63.58, -11.91 in-in-in SNCiii in-in ActLoopNT-in 2.979 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.89, -24.96 APE9-dihe-na -114.96, 153.64 APE8-dihe-in -59.59, 137.04 APE8-rot-in 298.26 APE67-dihe-in -58.73, -33.95 -50.83, -38.96 APE12-dist-in 13.278 APE11-dist-in 11.409 APE10-dist-in 7.043 APE9-dist-in 3.916 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 B 344 326 0 0 0 0 [[727, 1020]] 1.0 8buo Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BURE Q9NYV4 715 1040 1490.0 RQU:61101 Type1 Inactive DFGin 6.885 15.844 ABAminus -134.08, -49.7 -100.21, 93.56 -92.36, 24.23 284.18, 80.41 -66.46, -36.08 in-in in 8.216 Saltbr-in 2.802 HRD-in -63.9, -48.8 70.15, 6.43 in-in-out SNCiio in-out ActLoopNT-in 2.927 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -92.25, -40.02 APE9-dihe-na -84.05, 150.42 APE8-dihe-in -60.84, 144.54 APE8-rot-out 183.23 APE67-dihe-in -64.31, -32.85 -49.71, -40.37 APE12-dist-in 12.244 APE11-dist-in 11.971 APE10-dist-in 6.533 APE9-dist-in 3.85 K965R TPO893 TPO893 XRAY 3.64 0.192 0.234 E 344 326 0 0 0 0 [[727, 1020]] 1.0 8bur Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUSH Q9NYV4 715 1044 1490.0 RMX:1101 Type1 Inactive DFGin 6.901 15.069 ABAminus -143.82, 12.24 -131.03, 98.54 -110.73, 33.01 294.28, 70.2 -74.22, -18.61 in-in in 7.947 Saltbr-in 3.124 HRD-in -74.26, -49.18 68.04, 9.28 in-in-in SNCiii in-in ActLoopNT-in 2.847 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -102.73, -48.18 APE9-dihe-na -92.8, 152.41 APE8-dihe-in -59.01, 141.68 APE8-rot-in 303.45 APE67-dihe-in -64.79, -31.26 -52.5, -37.48 APE12-dist-in 13.661 APE11-dist-in 11.986 APE10-dist-in 7.2 APE9-dist-in 3.737 K965R TPO893 TPO893 XRAY 3.26 0.209 0.228 H 344 330 0 0 0 0 [[727, 1020]] 1.0 8bus Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUTB Q9NYV4 715 1039 1490.0 RQ5:61101 Type1 Inactive DFGin 7.056 15.396 ABAminus -130.15, -50.58 -94.08, 102.79 -101.3, 34.01 287.2, 80.24 -71.28, -33.81 in-in in 8.178 Saltbr-in 3.454 HRD-in -68.35, -50.74 72.26, 0.96 in-in-out SNCiio in-out ActLoopNT-in 2.855 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -102.11, -52.89 APE9-dihe-na -83.71, 152.96 APE8-dihe-in -63.18, 146.03 APE8-rot-out 183.88 APE67-dihe-in -64.84, -30.01 -53.45, -39.74 APE12-dist-in 13.152 APE11-dist-in 11.752 APE10-dist-in 6.876 APE9-dist-in 3.664 K965R TPO893 TPO893 XRAY 3.25 0.198 0.217 B 344 325 0 0 0 0 [[727, 1020]] 1.0 8but Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUTH Q9NYV4 715 1043 1490.0 RQ5:61101 Type1 Inactive DFGin 7.093 15.421 ABAminus -128.56, -49.4 -93.56, 100.15 -99.66, 30.54 282.78, 78.32 -73.44, -31.71 in-in in 8.09 Saltbr-in 3.514 HRD-in -72.59, -52.14 71.01, -0.2 in-in-in SNCiii in-in ActLoopNT-in 2.746 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -103.31, -52.45 APE9-dihe-na -84.96, 155.97 APE8-dihe-in -63.11, 145.04 APE8-rot-in 301.85 APE67-dihe-in -65.27, -28.99 -54.91, -40.74 APE12-dist-in 13.688 APE11-dist-in 12.03 APE10-dist-in 7.147 APE9-dist-in 3.489 K965R TPO893 TPO893 XRAY 3.25 0.198 0.217 H 344 329 0 0 0 0 [[727, 1020]] 1.0 8but Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 7NXKA Q9NYV4 715 1040 1490.0 UUB:2000 Type1 Inactive DFGin 7.399 15.487 ABAminus -95.46, -72.72 -129.88, 136.0 -106.22, 48.24 290.77, 75.67 -65.42, -30.99 in-none in 8.908 Saltbr-none 999.0 HRD-out -77.5, 146.77 -128.84, 17.49 none-in-out SNCnio in-out ActLoopNT-in 2.97 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.63, -48.96 APE9-dihe-na -98.39, 153.96 APE8-dihe-in -58.36, 147.85 APE8-rot-out 42.54 APE67-dihe-in -71.34, -26.96 -59.32, -29.48 APE12-dist-in 12.842 APE11-dist-in 11.116 APE10-dist-in 6.75 APE9-dist-in 3.445 None TPO893 TPO893 XRAY 3.0 0.222 0.264 A 351 322 4 0 0 0 [[727, 1020]] 1.0 7nxk Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 9FMRE Q9NYV4 714 1042 1490.0 RMF:61101 Type1 Inactive DFGin 6.793 14.64 ABAminus -113.83, -79.52 -84.15, 118.47 -115.27, 16.16 293.54, 100.02 -64.02, -34.33 in-out in 9.633 Saltbr-out 3.612 HRD-out -79.17, 82.22 -59.96, 8.89 out-in-out SNCoio in-out ActLoopNT-in 3.026 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -148.14, -27.51 APE9-dihe-na -104.44, 148.12 APE8-dihe-in -51.45, 137.55 APE8-rot-in 306.02 APE67-dihe-in -70.5, -21.3 -54.61, -36.19 APE12-dist-out 14.298 APE11-dist-in 12.211 APE10-dist-in 7.469 APE9-dist-in 3.767 None TPO893 TPO893 XRAY 3.9 0.209 0.25 E 351 329 0 0 0 0 [[727, 1020]] 1.0 9fmr Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 9FMRH Q9NYV4 714 1044 1490.0 RMF:61101 Type1 Inactive DFGin 6.801 14.603 ABAminus -113.95, -78.4 -84.85, 124.02 -118.87, 17.95 291.29, 89.7 -63.88, -35.4 in-in in 8.592 Saltbr-in 3.552 HRD-in -72.47, -40.65 59.82, 5.57 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.74, -27.71 APE9-dihe-na -103.25, 148.34 APE8-dihe-in -51.07, 136.63 APE8-rot-in 306.14 APE67-dihe-in -69.99, -21.15 -54.39, -34.8 APE12-dist-in 13.823 APE11-dist-in 12.098 APE10-dist-in 7.255 APE9-dist-in 3.608 None TPO893 TPO893 XRAY 3.9 0.209 0.25 H 351 331 0 0 0 0 [[727, 1020]] 1.0 9fmr Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 4CXAA Q9NYV4 718 1050 1490.0 ANP:2051 ATPlike Inactive DFGin 6.436 15.022 BLAminus -127.47, 178.63 59.83, 84.78 -103.34, 39.58 291.64, 72.71 -78.99, -14.54 in-in in 8.178 Saltbr-in 2.513 HRD-in -89.68, -50.66 63.81, 17.68 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.43, 159.2 APE9-dihe-na 63.92, 139.76 APE8-dihe-in -56.37, 145.01 APE8-rot-out 63.76 APE67-dihe-in -64.68, -22.99 -55.23, -40.79 APE12-dist-in 13.212 APE11-dist-in 11.662 APE10-dist-in 7.363 APE9-dist-in 3.506 None TPO893 TPO893 XRAY 3.15 0.224 0.279 A 340 330 3 0 0 1 [[727, 1020]] 1.0 4cxa Homo sapiens CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 4NSTA Q9NYV4 716 1046 1490.0 ADP:1101 ATPlike Inactive DFGin 6.978 15.111 BLAminus -127.54, 179.84 60.58, 76.06 -95.3, 23.79 283.73, 86.71 -65.43, -16.77 in-in in 8.988 Saltbr-in 3.031 HRD-in -82.28, -56.37 71.8, 9.39 in-in-out SNCiio in-out ActLoopNT-in 2.956 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.59, 153.12 APE9-dihe-na 76.09, 132.29 APE8-dihe-in -60.41, 149.83 APE8-rot-out 85.48 APE67-dihe-in -64.83, -28.79 -60.07, -39.7 APE12-dist-in 13.247 APE11-dist-in 11.273 APE10-dist-in 6.995 APE9-dist-in 3.461 None TPO893 TPO893 XRAY 2.2 0.198 0.24 A 351 323 8 0 0 0 [[727, 1020]] 1.0 4nst Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 4NSTC Q9NYV4 717 1045 1490.0 ADP:1101 ATPlike Inactive DFGin 6.972 15.168 BLAminus -122.49, -178.57 55.97, 75.42 -92.86, 20.68 283.24, 86.31 -56.98, -20.08 in-in in 8.863 Saltbr-in 2.957 HRD-in -69.12, -51.54 66.96, 15.75 in-in-out SNCiio in-out ActLoopNT-in 2.928 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.74, 152.42 APE9-dihe-na 82.09, 126.12 APE8-dihe-in -62.22, 152.62 APE8-rot-out 78.32 APE67-dihe-in -63.16, -30.08 -57.73, -42.25 APE12-dist-in 13.202 APE11-dist-in 11.267 APE10-dist-in 6.942 APE9-dist-in 3.705 None TPO893 TPO893 XRAY 2.2 0.198 0.24 C 351 318 11 0 0 1 [[727, 1020]] 1.0 4nst Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 4UN0C Q9NYV4 719 1036 1490.0 No_ligand No_ligand Inactive DFGin 7.232 15.503 BLAminus -124.23, -178.57 61.68, 76.73 -100.84, 26.92 286.01, 6.79 -65.68, -44.77 in-none in 8.995 Saltbr-none 999.0 HRD-in -69.99, -50.49 63.23, 23.44 none-in-out SNCnio in-out ActLoopNT-in 2.936 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -139.84, 155.57 APE9-dihe-na 72.34, -14.08 APE8-dihe-out 67.52, 158.6 APE8-rot-out 70.66 APE67-dihe-in -58.83, -37.69 -56.4, -50.16 APE12-dist-in 13.127 APE11-dist-in 10.764 APE10-dist-in 7.944 APE9-dist-in 3.927 None TPO893 TPO893 XRAY 3.15 0.217 0.271 C 326 309 9 0 0 0 [[727, 1020]] 1.0 4un0 Homo sapiens CMGC_CDK12_HUMAN CMGC 2.2e-84 289.2 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 4UN0D Q9NYV4 723 1024 1490.0 No_ligand No_ligand Inactive DFGin 7.195 15.47 BLAminus -123.96, -178.26 62.11, 76.94 -101.1, 26.4 286.66, 6.77 -66.07, -44.8 in-none in 8.959 Saltbr-none 999.0 HRD-in -70.01, -50.55 63.3, 23.26 none-in-out SNCnio in-out ActLoopNT-in 2.807 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -139.6, 156.23 APE9-dihe-na 75.54, -12.58 APE8-dihe-out 66.76, 157.7 APE8-rot-out 70.35 APE67-dihe-in -58.41, -37.99 -56.68, -49.87 APE12-dist-in 13.211 APE11-dist-in 11.101 APE10-dist-in 7.972 APE9-dist-in 3.956 None TPO893 TPO893 XRAY 3.15 0.217 0.271 D 326 277 25 0 0 5 [[727, 1020]] 1.0 4un0 Homo sapiens CMGC_CDK12_HUMAN CMGC 2.2e-84 289.2 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 4CXAC Q9NYV4 718 1048 1490.0 No_ligand No_ligand Inactive DFGin 7.199 15.248 BLAminus -126.07, 177.23 58.72, 82.97 -102.36, 37.62 286.53, 69.22 -80.81, -13.97 in-none in 8.046 Saltbr-none 999.0 HRD-in -86.15, -47.73 62.33, 17.56 none-in-out SNCnio in-out ActLoopNT-in 3.047 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.86, 161.73 APE9-dihe-na 68.73, 142.31 APE8-dihe-in -55.95, 146.27 APE8-rot-out 63.52 APE67-dihe-in -66.87, -27.84 -54.72, -39.98 APE12-dist-in 13.18 APE11-dist-in 11.907 APE10-dist-in 7.481 APE9-dist-in 3.577 None TPO893 TPO893 XRAY 3.15 0.224 0.279 C 340 331 0 0 0 0 [[727, 1020]] 1.0 4cxa Homo sapiens CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU2E Q9NYV4 715 1039 1490.0 No_ligand No_ligand Inactive DFGin 7.379 15.57 BLAminus -136.39, 179.92 48.57, 72.52 -89.87, 33.71 279.3, 90.07 -78.07, -11.47 in-in in 7.911 Saltbr-in 3.147 HRD-in -74.54, -52.71 71.43, 6.76 in-in-out SNCiio in-out ActLoopNT-in 2.869 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.65, -39.48 APE9-dihe-na -100.87, 155.56 APE8-dihe-in -58.32, 146.43 APE8-rot-out 175.64 APE67-dihe-in -62.37, -35.72 -53.25, -43.67 APE12-dist-in 13.394 APE11-dist-in 12.571 APE10-dist-in 7.149 APE9-dist-in 3.738 K965R TPO893 TPO893 XRAY 3.13 0.193 0.217 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bu2 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUDE Q9NYV4 715 1043 1490.0 No_ligand No_ligand Inactive DFGin 7.272 15.453 BLAminus -143.83, -177.07 47.13, 79.14 -96.0, 35.58 285.18, 78.34 -74.8, -28.12 in-in in 8.105 Saltbr-in 3.075 HRD-in -66.78, -51.99 75.75, 3.43 in-in-out SNCiio in-out ActLoopNT-in 2.985 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -100.45, -19.67 APE9-dihe-na -95.18, 153.43 APE8-dihe-in -60.73, 146.92 APE8-rot-out 173.58 APE67-dihe-in -62.46, -23.72 -59.64, -41.84 APE12-dist-in 13.058 APE11-dist-in 12.497 APE10-dist-in 6.772 APE9-dist-in 3.404 K965R TPO893 TPO893 XRAY 3.2 0.191 0.22 E 344 329 0 0 0 0 [[727, 1020]] 1.0 8bud Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUGE Q9NYV4 715 1039 1490.0 No_ligand No_ligand Inactive DFGin 7.508 15.743 BLAminus -142.95, -165.93 46.31, 64.06 -92.32, 17.1 280.22, 84.99 -61.9, -35.84 in-in in 8.212 Saltbr-in 3.113 HRD-in -63.09, -51.61 71.91, 6.47 in-in-out SNCiio in-out ActLoopNT-in 2.956 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -74.97, -44.52 APE9-dihe-na -69.42, 151.3 APE8-dihe-in -61.28, 146.55 APE8-rot-out 168.8 APE67-dihe-in -63.35, -29.72 -54.01, -46.01 APE12-dist-in 13.222 APE11-dist-in 12.722 APE10-dist-in 6.946 APE9-dist-in 3.431 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bug Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 6B3EA Q9NYV4 717 1036 1490.0 CJM:1102 Type1 Inactive DFGin 7.202 14.766 BLAminus -121.7, 178.92 59.35, 79.81 -95.65, 26.66 285.79, 81.49 -61.82, -29.55 in-in in 8.699 Saltbr-in 3.05 HRD-in -76.48, -54.37 70.53, 12.96 in-in-out SNCiio in-out ActLoopNT-in 2.914 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.0, 155.78 APE9-dihe-na 76.06, 131.42 APE8-dihe-in -60.49, 145.1 APE8-rot-out 86.32 APE67-dihe-in -63.58, -25.36 -47.54, -46.44 APE12-dist-in 13.355 APE11-dist-in 11.458 APE10-dist-in 6.977 APE9-dist-in 3.497 None TPO893 TPO893 XRAY 3.06 0.191 0.212 A 320 310 10 0 0 0 [[727, 1020]] 1.0 6b3e Homo sapiens CMGC_CDK12_HUMAN CMGC 2e-84 289.3 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 6B3EC Q9NYV4 719 1036 1490.0 CJM:1103 Type1 Inactive DFGin 7.173 14.621 BLAminus -121.27, -179.9 57.69, 80.64 -96.21, 26.0 285.96, 80.56 -59.62, -30.89 in-in in 8.528 Saltbr-in 2.838 HRD-in -74.96, -53.91 69.51, 14.07 in-in-out SNCiio in-out ActLoopNT-in 2.894 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.93, 154.64 APE9-dihe-na 78.03, 130.48 APE8-dihe-in -61.1, 145.82 APE8-rot-out 85.07 APE67-dihe-in -62.57, -25.75 -47.61, -47.19 APE12-dist-in 13.267 APE11-dist-in 11.359 APE10-dist-in 6.944 APE9-dist-in 3.562 None TPO893 TPO893 XRAY 3.06 0.191 0.212 C 320 308 10 0 0 0 [[727, 1020]] 1.0 6b3e Homo sapiens CMGC_CDK12_HUMAN CMGC 2e-84 289.3 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 5ACBC Q9NYV4 716 1040 1490.0 5I1:2000 Type1 Inactive DFGin 7.442 15.98 BLAminus -120.77, 171.13 69.09, 68.44 -91.07, 27.42 288.67, 78.45 -57.05, -52.5 in-in in 8.369 Saltbr-in 2.878 HRD-in -75.39, -52.07 67.69, 20.88 in-in-out SNCiio in-out ActLoopNT-in 2.804 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.05, 158.72 APE9-dihe-na 71.72, 133.31 APE8-dihe-in -62.63, 141.8 APE8-rot-out 192.05 APE67-dihe-in -62.93, -27.37 -47.97, -41.23 APE12-dist-in 13.642 APE11-dist-in 11.666 APE10-dist-in 7.394 APE9-dist-in 3.53 None TPO893 TPO893 XRAY 2.7 0.223 0.262 C 340 325 0 0 0 0 [[727, 1020]] 1.0 5acb Homo sapiens CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 5ACBD Q9NYV4 718 1044 1490.0 5I1:2000 Type1 Inactive DFGin 7.452 16.011 BLAminus -121.14, 171.65 68.87, 69.17 -92.34, 27.19 288.77, 78.24 -58.4, -50.08 in-in in 8.349 Saltbr-in 2.875 HRD-in -75.87, -51.87 67.36, 21.14 in-in-out SNCiio in-out ActLoopNT-in 2.811 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.18, 158.62 APE9-dihe-na 71.07, 133.26 APE8-dihe-in -63.22, 142.55 APE8-rot-out 191.44 APE67-dihe-in -63.33, -26.97 -48.15, -41.58 APE12-dist-in 13.698 APE11-dist-in 11.768 APE10-dist-in 7.486 APE9-dist-in 3.567 None TPO893 TPO893 XRAY 2.7 0.223 0.262 D 340 320 7 0 0 3 [[727, 1020]] 1.0 5acb Homo sapiens CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 9JK1A Q9NYV4 717 1039 1490.0 A1EB3:1202 Type1 Inactive DFGin 7.136 16.194 BLAminus -133.53, 173.61 54.27, 71.41 -88.96, 16.92 270.96, 77.73 -63.15, -30.31 in-in in 8.497 Saltbr-in 3.285 HRD-in -81.17, -44.88 64.66, 14.44 in-in-out SNCiio in-out ActLoopNT-in 2.857 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.0, -26.54 APE9-dihe-na -103.25, 143.89 APE8-dihe-in -52.76, 144.9 APE8-rot-out 169.48 APE67-dihe-in -66.06, -18.64 -58.71, -34.25 APE12-dist-in 13.75 APE11-dist-in 12.265 APE10-dist-in 7.176 APE9-dist-in 3.888 None TPO893 TPO893 XRAY 2.72 0.249 0.267 A 340 311 12 0 0 2 [[727, 1020]] 1.0 9jk1 Homo sapiens CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 9JK1B Q9NYV4 715 1039 1490.0 A1EB3:1101 Type1 Inactive DFGin 6.974 15.796 BLAminus -131.76, 174.62 55.08, 70.72 -88.19, 16.31 271.01, 79.18 -62.74, -29.13 in-in in 8.517 Saltbr-in 3.036 HRD-in -81.5, -44.39 65.05, 13.56 in-in-out SNCiio in-out ActLoopNT-in 3.15 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.88, -41.9 APE9-dihe-na -106.09, 143.29 APE8-dihe-in -52.94, 146.84 APE8-rot-out 167.82 APE67-dihe-in -65.97, -16.6 -59.29, -37.44 APE12-dist-in 13.616 APE11-dist-in 11.584 APE10-dist-in 7.243 APE9-dist-in 3.661 None TPO893 TPO893 XRAY 2.72 0.249 0.267 B 340 315 10 0 0 0 [[727, 1020]] 1.0 9jk1 Homo sapiens CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 6TD3B Q9NYV4 715 1047 1490.0 RC8:1101 Type1 Inactive DFGin 7.072 15.376 BLAminus -144.85, 177.87 66.18, 66.81 -86.27, 29.11 284.0, 81.86 -68.57, -26.95 in-in in 7.94 Saltbr-in 3.098 HRD-in -75.0, -46.5 66.33, 3.67 in-in-out SNCiio in-out ActLoopNT-in 2.962 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.74, 152.33 APE9-dihe-na 70.44, 153.31 APE8-dihe-in -72.7, 152.08 APE8-rot-out 190.09 APE67-dihe-in -62.32, -35.85 -49.81, -38.44 APE12-dist-in 13.58 APE11-dist-in 10.993 APE10-dist-in 7.153 APE9-dist-in 3.643 K965R TPO893 TPO893 XRAY 3.46 0.195 0.22 B 344 333 0 0 0 0 [[727, 1020]] 1.0 6td3 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 6TD3H Q9NYV4 715 1047 1490.0 RC8:1101 Type1 Inactive DFGin 7.008 15.067 BLAminus -125.85, 165.87 77.73, 76.18 -92.06, 29.13 290.22, 73.9 -71.24, -38.15 in-in in 7.898 Saltbr-in 3.073 HRD-in -75.01, -45.87 63.18, 11.24 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -152.2, 169.13 APE9-dihe-na 75.43, 19.72 APE8-dihe-out 60.33, 162.48 APE8-rot-out 98.13 APE67-dihe-in -64.24, -27.06 -78.21, -44.67 APE12-dist-in 13.905 APE11-dist-in 11.902 APE10-dist-in 7.407 APE9-dist-in 3.189 K965R TPO893 TPO893 XRAY 3.46 0.195 0.22 H 344 333 0 0 0 0 [[727, 1020]] 1.0 6td3 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU1E Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 7.068 15.214 BLAminus -136.12, -177.54 44.75, 87.14 -99.51, 30.27 285.35, 73.68 -68.31, -25.33 in-in in 7.794 Saltbr-in 3.1 HRD-in -77.94, -49.77 74.02, -0.64 in-in-out SNCiio in-out ActLoopNT-in 2.691 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.97, -45.94 APE9-dihe-na -80.52, 149.74 APE8-dihe-in -60.97, 145.17 APE8-rot-out 178.02 APE67-dihe-in -66.77, -27.56 -51.22, -43.09 APE12-dist-in 13.018 APE11-dist-in 12.227 APE10-dist-in 6.992 APE9-dist-in 3.549 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 E 344 330 0 0 0 0 [[727, 1020]] 1.0 8bu1 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU4E Q9NYV4 715 1039 1490.0 RQL:61101 Type1 Inactive DFGin 7.468 15.54 BLAminus -141.1, 177.81 60.96, 67.17 -93.67, 20.14 286.75, 91.51 -68.13, -33.02 in-out in 8.589 Saltbr-out 5.378 HRD-in -65.76, -60.59 77.41, 5.82 out-in-out SNCoio in-out ActLoopNT-in 3.03 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -92.44, -31.45 APE9-dihe-na -85.2, 150.66 APE8-dihe-in -60.73, 147.65 APE8-rot-out 173.82 APE67-dihe-in -63.61, -27.41 -58.33, -41.33 APE12-dist-in 13.082 APE11-dist-in 12.596 APE10-dist-in 6.898 APE9-dist-in 3.368 K965R TPO893 TPO893 XRAY 3.09 0.205 0.223 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bu4 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU6E Q9NYV4 715 1038 1490.0 RQE:61101 Type1 Inactive DFGin 6.904 14.793 BLAminus -142.16, 173.3 46.61, 77.13 -86.78, 22.75 290.79, 69.64 -59.06, -38.89 in-out in 8.466 Saltbr-out 3.779 HRD-in -71.31, -54.36 76.0, -0.16 out-in-out SNCoio in-out ActLoopNT-in 2.982 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -121.41, -43.86 APE9-dihe-na -68.68, 149.74 APE8-dihe-in -53.47, 142.92 APE8-rot-out 167.33 APE67-dihe-in -57.01, -34.74 -57.51, -41.34 APE12-dist-in 13.103 APE11-dist-in 13.082 APE10-dist-in 7.18 APE9-dist-in 3.547 K965R TPO893 TPO893 XRAY 3.45 0.219 0.249 E 344 324 0 0 0 0 [[727, 1020]] 1.0 8bu6 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU7E Q9NYV4 715 1043 1490.0 RS5:1101 Type1 Inactive DFGin 6.913 15.331 BLAminus -151.87, 179.81 58.39, 58.15 -75.44, 35.18 288.34, 71.23 -65.18, -38.03 in-in in 7.757 Saltbr-in 2.771 HRD-in -65.82, -48.21 71.8, 2.22 in-in-out SNCiio in-out ActLoopNT-in 2.88 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -76.27, -35.49 APE9-dihe-na -79.69, 146.79 APE8-dihe-in -61.33, 142.24 APE8-rot-out 178.46 APE67-dihe-in -63.9, -29.29 -50.85, -42.32 APE12-dist-in 12.527 APE11-dist-in 12.336 APE10-dist-in 6.449 APE9-dist-in 3.489 K965R TPO893 TPO893 XRAY 3.245 0.193 0.219 E 344 329 0 0 0 0 [[727, 1020]] 1.0 8bu7 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU9E Q9NYV4 715 1039 1490.0 RRC:61101 Type1 Inactive DFGin 6.994 15.296 BLAminus -144.01, 174.3 58.02, 76.59 -92.29, 23.22 284.15, 79.53 -66.56, -16.01 in-in in 7.926 Saltbr-in 2.978 HRD-in -72.29, -52.87 75.22, 4.09 in-in-out SNCiio in-out ActLoopNT-in 2.953 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -79.11, -41.8 APE9-dihe-na -74.19, 150.88 APE8-dihe-in -62.82, 143.67 APE8-rot-out 166.93 APE67-dihe-in -61.65, -28.3 -55.31, -42.74 APE12-dist-in 13.003 APE11-dist-in 12.713 APE10-dist-in 6.892 APE9-dist-in 3.475 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bu9 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUBB Q9NYV4 715 1041 1490.0 RNU:61101 Type1 Inactive DFGin 7.183 15.861 BLAminus -140.81, -179.71 59.34, 42.69 -57.7, -43.03 281.93, 72.19 -135.84, 169.59 in-in in 7.816 Saltbr-in 3.03 HRD-out -85.59, 106.33 -67.25, -35.7 in-out-out SNCioo out-out ActLoopNT-out 15.083 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -58.9, -41.94 APE9-dihe-na -63.9, -43.28 APE8-dihe-out -57.35, -36.53 APE8-rot-in 303.78 APE67-dihe-in -55.9, -22.59 -60.27, -40.25 APE12-dist-in 10.517 APE11-dist-in 13.521 APE10-dist-out 17.379 APE9-dist-out 11.733 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 B 344 327 0 0 0 0 [[727, 1020]] 1.0 8bub Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUBE Q9NYV4 715 1043 1490.0 RNU:61101 Type1 Inactive DFGin 7.121 15.718 BLAminus -151.03, 179.83 54.33, 46.25 -61.28, -40.39 279.04, 68.48 -138.85, 169.0 in-in in 8.261 Saltbr-in 2.913 HRD-out -90.61, 99.83 -68.22, -35.13 in-out-out SNCioo out-out ActLoopNT-out 14.624 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -60.24, -43.43 APE9-dihe-na -66.88, -44.0 APE8-dihe-out -57.36, -41.95 APE8-rot-in 294.1 APE67-dihe-in -53.67, -21.91 -61.1, -39.92 APE12-dist-in 10.606 APE11-dist-out 14.793 APE10-dist-out 17.915 APE9-dist-out 11.298 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 E 344 329 0 0 0 0 [[727, 1020]] 1.0 8bub Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUCE Q9NYV4 715 1039 1490.0 RKO:61101 Type1 Inactive DFGin 7.236 15.335 BLAminus -141.04, 176.79 52.98, 78.31 -91.94, 30.22 286.84, 76.41 -65.41, -31.19 in-in in 7.961 Saltbr-in 2.908 HRD-in -69.25, -49.18 71.49, 1.27 in-in-out SNCiio in-out ActLoopNT-in 2.87 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -94.07, -41.15 APE9-dihe-na -76.31, 151.65 APE8-dihe-in -63.11, 145.53 APE8-rot-out 179.86 APE67-dihe-in -66.95, -27.99 -55.33, -37.54 APE12-dist-in 12.996 APE11-dist-in 12.54 APE10-dist-in 6.8 APE9-dist-in 3.464 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8buc Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUEE Q9NYV4 715 1039 1490.0 RVU:61101 Type1 Inactive DFGin 7.242 15.496 BLAminus -141.72, -174.7 47.09, 73.46 -90.8, 38.01 284.87, 78.5 -78.36, -22.84 in-in in 7.983 Saltbr-in 3.324 HRD-in -72.61, -56.11 78.07, 3.62 in-in-out SNCiio in-out ActLoopNT-in 2.863 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -101.94, -25.35 APE9-dihe-na -96.92, 153.79 APE8-dihe-in -59.83, 147.51 APE8-rot-out 172.74 APE67-dihe-in -64.75, -28.9 -55.27, -41.29 APE12-dist-in 12.98 APE11-dist-in 12.541 APE10-dist-in 7.005 APE9-dist-in 3.371 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bue Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUFE Q9NYV4 715 1043 1490.0 RW6:61101 Type1 Inactive DFGin 7.236 15.613 BLAminus -139.81, -179.98 50.46, 82.76 -97.71, 35.51 286.32, 76.93 -72.96, -20.08 in-in in 8.207 Saltbr-in 3.083 HRD-in -73.52, -52.81 75.99, 1.49 in-in-out SNCiio in-out ActLoopNT-in 3.139 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -94.42, -47.71 APE9-dihe-na -72.58, 149.04 APE8-dihe-in -62.45, 149.79 APE8-rot-out 175.62 APE67-dihe-in -64.49, -29.41 -54.77, -42.48 APE12-dist-in 12.629 APE11-dist-in 12.345 APE10-dist-in 6.616 APE9-dist-in 3.281 K965R TPO893 TPO893 XRAY 3.3 0.185 0.22 E 344 329 0 0 0 0 [[727, 1020]] 1.0 8buf Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUHE Q9NYV4 715 1034 1490.0 RR9:61101 Type1 Inactive DFGin 7.186 15.729 BLAminus -148.68, -172.98 46.52, 61.7 -84.29, 18.93 287.47, 71.85 -64.36, -25.08 in-in in 8.292 Saltbr-in 3.146 HRD-in -67.53, -47.52 70.08, 2.73 in-in-out SNCiio in-out ActLoopNT-in 2.955 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -76.87, -40.28 APE9-dihe-na -73.29, 157.3 APE8-dihe-in -67.11, 147.48 APE8-rot-out 173.32 APE67-dihe-in -62.13, -36.27 -57.69, -39.06 APE12-dist-in 13.369 APE11-dist-in 12.874 APE10-dist-in 7.086 APE9-dist-in 3.487 K965R TPO893 TPO893 XRAY 3.79 0.189 0.232 E 344 320 0 0 0 0 [[727, 1020]] 1.0 8buh Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUIE Q9NYV4 715 1039 1490.0 RV6:1101 Type1 Inactive DFGin 7.539 15.558 BLAminus -143.87, -178.18 39.61, 79.76 -92.26, 22.29 284.74, 80.02 -58.61, -17.16 in-out in 8.11 Saltbr-out 3.715 HRD-out -75.62, 149.49 -131.37, 158.61 out-in-out SNCoio in-out ActLoopNT-in 3.167 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -99.18, -17.3 APE9-dihe-na -88.48, 155.1 APE8-dihe-in -64.43, 139.92 APE8-rot-out 15.61 APE67-dihe-in -61.18, -34.77 -50.17, -41.15 APE12-dist-in 13.019 APE11-dist-in 12.914 APE10-dist-in 7.019 APE9-dist-out 6.027 K965R TPO893 TPO893 XRAY 3.5 0.184 0.221 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bui Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUJE Q9NYV4 715 1043 1490.0 RUW:1101 Type1 Inactive DFGin 7.403 15.559 BLAminus -141.86, -179.96 50.47, 61.92 -80.29, 20.39 278.49, 79.05 -71.07, 143.46 in-out in 7.788 Saltbr-out 4.375 HRD-in -62.58, -56.77 78.09, -0.63 out-in-in SNCoii in-in ActLoopNT-in 3.099 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.26, -45.94 APE9-dihe-na -81.75, 154.86 APE8-dihe-in -61.95, 146.07 APE8-rot-in 291.01 APE67-dihe-in -60.95, -32.29 -58.05, -37.51 APE12-dist-in 12.792 APE11-dist-in 12.176 APE10-dist-in 7.086 APE9-dist-in 3.43 K965R TPO893 TPO893 XRAY 3.62 0.164 0.206 E 344 329 0 0 0 0 [[727, 1020]] 1.0 8buj Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUKE Q9NYV4 715 1039 1490.0 RWE:61101 Type1 Inactive DFGin 7.127 15.205 BLAminus -148.82, 179.05 51.44, 70.31 -90.34, 37.33 288.85, 69.46 -77.88, -21.75 in-in in 8.114 Saltbr-in 2.955 HRD-in -69.03, -55.19 75.3, 6.2 in-in-out SNCiio in-out ActLoopNT-in 3.068 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -77.16, -37.78 APE9-dihe-na -75.17, 151.97 APE8-dihe-in -63.51, 147.07 APE8-rot-out 163.95 APE67-dihe-in -64.24, -27.64 -56.09, -42.19 APE12-dist-in 12.843 APE11-dist-in 12.42 APE10-dist-in 6.565 APE9-dist-in 3.319 K965R TPO893 TPO893 XRAY 3.41 0.186 0.21 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8buk Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUNE Q9NYV4 715 1039 1490.0 RNF:61101 Type1 Inactive DFGin 7.217 15.313 BLAminus -143.55, -179.06 50.55, 77.42 -92.12, 34.85 285.27, 76.47 -72.26, -18.51 in-in in 7.824 Saltbr-in 3.046 HRD-in -77.13, -53.65 75.0, -0.22 in-in-out SNCiio in-out ActLoopNT-in 2.924 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.31, -34.23 APE9-dihe-na -92.08, 151.91 APE8-dihe-in -57.84, 145.99 APE8-rot-out 175.35 APE67-dihe-in -65.98, -29.37 -55.72, -38.5 APE12-dist-in 13.18 APE11-dist-in 12.611 APE10-dist-in 7.008 APE9-dist-in 3.432 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bun Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUOE Q9NYV4 715 1040 1490.0 RLC:1101 Type1 Inactive DFGin 6.942 15.62 BLAminus -143.37, -172.35 44.48, 74.17 -91.23, 22.68 280.06, 81.2 -62.03, -28.06 in-in in 8.068 Saltbr-in 3.056 HRD-out -76.67, 113.14 -91.39, -21.48 in-in-in SNCiii in-in ActLoopNT-in 2.893 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.19, -25.24 APE9-dihe-na -90.88, 153.8 APE8-dihe-in -61.01, 138.91 APE8-rot-in 296.79 APE67-dihe-in -57.07, -33.65 -55.69, -42.2 APE12-dist-in 12.516 APE11-dist-in 12.554 APE10-dist-in 6.839 APE9-dist-in 3.735 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 E 344 326 0 0 0 0 [[727, 1020]] 1.0 8buo Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUPB Q9NYV4 715 1027 1490.0 RWN:61101 Type1 Inactive DFGin 7.376 16.292 BLAminus -145.67, -178.63 51.5, 56.05 -75.52, 21.8 268.89, 78.21 -77.2, 158.24 in-in in 7.988 Saltbr-in 3.547 HRD-out -85.14, 78.87 -56.17, -33.42 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.18, -2.81 APE9-dihe-na -129.4, 158.55 APE8-dihe-in -65.53, 143.29 APE8-rot-in 297.85 APE67-dihe-in -63.16, -33.23 -55.07, -39.7 APE12-dist-in 12.626 APE11-dist-in 11.325 APE10-dist-in 6.955 APE9-dist-in 4.075 K965R TPO893 TPO893 XRAY 3.41 0.201 0.223 B 344 313 0 0 0 0 [[727, 1020]] 1.0 8bup Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUPE Q9NYV4 715 1027 1490.0 RWN:61101 Type1 Inactive DFGin 7.372 15.546 BLAminus -147.42, 179.7 52.21, 60.23 -77.56, 28.73 281.63, 90.36 -71.43, -13.64 in-in in 8.034 Saltbr-in 3.239 HRD-out -86.98, 107.75 -88.22, 168.06 in-in-out SNCiio in-out ActLoopNT-in 2.894 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -126.76, -4.83 APE9-dihe-na -127.6, 153.97 APE8-dihe-in -68.53, 144.26 APE8-rot-out 182.45 APE67-dihe-in -60.96, -31.45 -55.15, -40.88 APE12-dist-in 12.523 APE11-dist-in 11.316 APE10-dist-in 6.957 APE9-dist-out 6.042 K965R TPO893 TPO893 XRAY 3.41 0.201 0.223 E 344 313 0 0 0 0 [[727, 1020]] 1.0 8bup Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUQB Q9NYV4 715 1039 1490.0 RQ9:61101 Type1 Inactive DFGin 6.913 15.301 BLAminus -151.69, -179.79 53.5, 72.83 -94.44, 24.81 291.0, 75.32 -66.25, -27.07 in-in in 8.272 Saltbr-in 3.302 HRD-in -68.63, -54.73 77.99, 1.83 in-in-out SNCiio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.29, -38.77 APE9-dihe-na -81.13, 155.19 APE8-dihe-in -64.33, 147.28 APE8-rot-out 195.9 APE67-dihe-in -60.12, -28.17 -56.8, -43.77 APE12-dist-in 13.559 APE11-dist-in 12.004 APE10-dist-in 6.43 APE9-dist-in 3.506 K965R TPO893 TPO893 XRAY 3.2 0.196 0.216 B 344 321 4 0 0 0 [[727, 1020]] 1.0 8buq Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUQE Q9NYV4 715 1027 1490.0 RQ9:61101 Type1 Inactive DFGin 7.362 15.341 BLAminus -149.68, 178.7 52.88, 71.39 -93.43, 23.22 287.54, 76.39 -69.29, -26.75 in-in in 8.145 Saltbr-in 3.15 HRD-in -69.4, -56.77 77.16, 3.04 in-in-out SNCiio in-out ActLoopNT-in 3.016 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -114.18, -38.9 APE9-dihe-na -82.51, 153.34 APE8-dihe-in -63.97, 150.36 APE8-rot-out 173.3 APE67-dihe-in -60.97, -26.14 -55.24, -44.87 APE12-dist-in 13.192 APE11-dist-in 12.463 APE10-dist-in 6.936 APE9-dist-in 3.336 K965R TPO893 TPO893 XRAY 3.2 0.196 0.216 E 344 313 0 0 0 0 [[727, 1020]] 1.0 8buq Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BURB Q9NYV4 715 1044 1490.0 RQU:61101 Type1 Inactive DFGin 7.013 15.984 BLAminus -143.02, -172.66 43.3, 72.03 -94.19, 20.72 281.71, 86.88 -65.05, -33.85 in-in in 8.311 Saltbr-in 3.336 HRD-in -64.7, -53.19 72.64, 8.15 in-in-out SNCiio in-out ActLoopNT-in 2.971 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -98.84, -39.21 APE9-dihe-na -79.75, 149.9 APE8-dihe-in -61.25, 143.48 APE8-rot-out 176.27 APE67-dihe-in -64.0, -30.04 -50.29, -42.66 APE12-dist-in 13.218 APE11-dist-in 12.765 APE10-dist-in 7.159 APE9-dist-in 3.447 K965R TPO893 TPO893 XRAY 3.64 0.192 0.234 B 344 330 0 0 0 0 [[727, 1020]] 1.0 8bur Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUSB Q9NYV4 715 1039 1490.0 RMX:1101 Type1 Inactive DFGin 7.077 15.719 BLAminus -138.42, 166.28 73.44, 73.47 -93.1, 22.82 287.17, 80.09 -62.57, -33.79 in-in in 8.507 Saltbr-in 3.315 HRD-in -69.35, -51.21 75.34, 13.48 in-in-out SNCiio in-out ActLoopNT-in 3.02 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -86.75, -38.52 APE9-dihe-na -91.11, 154.59 APE8-dihe-in -64.35, 150.44 APE8-rot-out 197.48 APE67-dihe-in -56.11, -29.02 -59.98, -43.72 APE12-dist-in 12.99 APE11-dist-in 12.559 APE10-dist-in 6.978 APE9-dist-in 3.871 K965R TPO893 TPO893 XRAY 3.26 0.209 0.228 B 344 325 0 0 0 0 [[727, 1020]] 1.0 8bus Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUTE Q9NYV4 715 1039 1490.0 RQ5:61101 Type1 Inactive DFGin 7.298 15.323 BLAminus -139.51, -178.35 41.51, 85.24 -101.61, 29.69 285.9, 80.14 -70.78, -30.56 in-in in 8.259 Saltbr-in 3.086 HRD-in -67.79, -50.31 72.32, 0.48 in-in-out SNCiio in-out ActLoopNT-in 2.93 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -100.83, -40.87 APE9-dihe-na -77.17, 152.92 APE8-dihe-in -63.05, 147.04 APE8-rot-out 167.97 APE67-dihe-in -65.55, -27.52 -54.27, -41.89 APE12-dist-in 12.932 APE11-dist-in 12.598 APE10-dist-in 6.808 APE9-dist-in 3.452 K965R TPO893 TPO893 XRAY 3.25 0.198 0.217 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8but Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 6CKXA Q9NYV4 722 1024 1490.0 8M1:1102 Type1 Inactive DFGin 7.032 14.821 BLAminus -136.28, -177.03 50.17, 81.66 -95.72, 28.97 286.79, 82.51 -69.6, -12.29 in-in in 8.977 Saltbr-in 3.084 HRD-in -75.68, -51.15 65.95, 11.38 in-in-out SNCiio in-out ActLoopNT-in 3.122 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -144.15, 162.82 APE9-dihe-na 64.99, 132.37 APE8-dihe-in -65.8, 148.5 APE8-rot-out 58.87 APE67-dihe-in -65.02, -18.1 -33.35, -57.74 APE12-dist-in 13.141 APE11-dist-in 11.06 APE10-dist-in 6.875 APE9-dist-in 3.495 None TPO893 TPO893 XRAY 2.8 0.21 0.251 A 351 293 10 0 0 0 [[727, 1020]] 1.0 6ckx Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 6CKXC Q9NYV4 722 1024 1490.0 8M1:1102 Type1 Inactive DFGin 6.986 14.758 BLAminus -135.84, -177.96 50.19, 82.31 -95.98, 27.29 286.66, 82.56 -71.33, -10.74 in-in in 8.982 Saltbr-in 3.064 HRD-in -76.42, -51.05 66.38, 11.81 in-in-out SNCiio in-out ActLoopNT-in 3.093 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -143.35, 161.59 APE9-dihe-na 66.9, 134.68 APE8-dihe-in -66.86, 147.72 APE8-rot-out 60.13 APE67-dihe-in -63.67, -17.47 -33.52, -58.49 APE12-dist-in 13.151 APE11-dist-in 11.188 APE10-dist-in 6.93 APE9-dist-in 3.524 None TPO893 TPO893 XRAY 2.8 0.21 0.251 C 351 293 10 0 0 0 [[727, 1020]] 1.0 6ckx Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 7NXKC Q9NYV4 717 1040 1490.0 UUB:2000 Type1 Inactive DFGin 7.239 15.362 BLAminus -141.93, -168.1 55.29, 66.48 -89.47, 23.2 285.63, 87.42 -65.95, -22.63 in-none in 9.164 Saltbr-none 999.0 HRD-in -59.09, -64.11 84.9, -5.29 none-in-out SNCnio in-out ActLoopNT-in 3.1 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.36, -24.98 APE9-dihe-na -111.23, 152.03 APE8-dihe-in -58.18, 144.58 APE8-rot-out 41.59 APE67-dihe-in -69.39, -10.03 -63.92, -28.51 APE12-dist-in 13.02 APE11-dist-in 11.29 APE10-dist-in 6.468 APE9-dist-in 3.467 None TPO893 TPO893 XRAY 3.0 0.222 0.264 C 351 314 10 0 0 0 [[727, 1020]] 1.0 7nxk Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUGH Q9NYV4 715 1039 1490.0 No_ligand No_ligand Inactive DFGin 6.896 15.598 None -126.85, -81.65 -69.29, 99.31 -95.06, 17.81 283.55, 80.77 -62.15, -37.73 in-out in 8.498 Saltbr-out 4.239 HRD-in -64.31, -53.09 70.58, 6.39 out-in-out SNCoio in-out ActLoopNT-in 3.082 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -77.05, -49.38 APE9-dihe-na -69.37, 152.54 APE8-dihe-in -59.34, 145.1 APE8-rot-out 62.3 APE67-dihe-in -62.01, -33.03 -53.97, -44.11 APE12-dist-in 12.973 APE11-dist-in 12.483 APE10-dist-in 6.588 APE9-dist-in 3.652 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 H 344 325 0 0 0 0 [[727, 1020]] 1.0 8bug Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU1B Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 6.888 15.298 None -128.47, -62.59 -80.73, 98.22 -97.65, 30.1 286.08, 74.34 -69.36, -27.39 in-in in 7.821 Saltbr-in 3.264 HRD-in -79.79, -51.42 72.8, -1.21 in-in-out SNCiio in-out ActLoopNT-in 2.713 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.4, -55.58 APE9-dihe-na -85.22, 150.62 APE8-dihe-in -62.26, 144.21 APE8-rot-out 179.44 APE67-dihe-in -65.72, -30.15 -51.5, -38.4 APE12-dist-in 13.282 APE11-dist-in 11.616 APE10-dist-in 6.901 APE9-dist-in 3.714 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 B 344 330 0 0 0 0 [[727, 1020]] 1.0 8bu1 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU1H Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 6.987 15.403 None -124.14, -66.45 -82.78, 98.54 -96.09, 28.76 284.79, 71.99 -70.28, -26.46 in-in in 7.866 Saltbr-in 3.166 HRD-in -79.63, -53.16 73.52, -1.03 in-in-out SNCiio in-out ActLoopNT-in 2.759 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.57, -50.83 APE9-dihe-na -86.52, 154.66 APE8-dihe-in -59.58, 143.86 APE8-rot-out 8.75 APE67-dihe-in -65.52, -30.46 -51.58, -39.94 APE12-dist-in 13.809 APE11-dist-in 12.214 APE10-dist-in 7.236 APE9-dist-in 3.595 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 H 344 330 0 0 0 0 [[727, 1020]] 1.0 8bu1 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU2B Q9NYV4 715 1041 1490.0 RVQ:61101 Type1 Inactive DFGin 6.981 15.316 None -126.39, -67.8 -89.47, 99.61 -92.58, 32.18 287.62, 78.29 -74.11, -9.98 in-in in 7.762 Saltbr-in 3.494 HRD-in -72.7, -49.44 72.16, 4.81 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.12, -45.69 APE9-dihe-na -96.32, 148.59 APE8-dihe-in -57.39, 143.59 APE8-rot-in 288.86 APE67-dihe-in -63.0, -36.42 -47.95, -40.21 APE12-dist-in 13.536 APE11-dist-in 11.73 APE10-dist-in 7.073 APE9-dist-in 3.726 K965R TPO893 TPO893 XRAY 3.13 0.193 0.217 B 344 327 0 0 0 0 [[727, 1020]] 1.0 8bu2 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU3B Q9NYV4 715 1040 1490.0 RSI:1101 Type1 Inactive DFGin 6.849 15.359 None -135.97, -63.81 -78.62, 93.23 -91.89, 22.93 285.59, 76.13 -60.89, -23.4 in-in in 7.993 Saltbr-in 2.817 HRD-in -67.65, -55.64 77.98, -1.58 in-in-in SNCiii in-in ActLoopNT-in 3.052 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.96, -44.7 APE9-dihe-na -101.31, 148.75 APE8-dihe-in -59.73, 145.03 APE8-rot-in 305.94 APE67-dihe-in -60.6, -36.33 -55.27, -39.92 APE12-dist-in 13.312 APE11-dist-in 11.542 APE10-dist-in 7.049 APE9-dist-in 3.383 K965R TPO893 TPO893 XRAY 3.42 0.187 0.213 B 344 326 0 0 0 0 [[727, 1020]] 1.0 8bu3 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU3H Q9NYV4 715 1044 1490.0 RSI:1101 Type1 Inactive DFGin 6.976 15.465 None -130.35, -57.76 -91.85, 92.73 -91.21, 19.54 285.51, 78.88 -63.9, -27.23 in-in in 8.132 Saltbr-in 3.281 HRD-in -66.37, -58.1 77.05, -1.53 in-in-out SNCiio in-out ActLoopNT-in 3.018 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.62, -44.32 APE9-dihe-na -91.3, 148.63 APE8-dihe-in -63.87, 147.34 APE8-rot-out 172.41 APE67-dihe-in -60.12, -36.58 -54.35, -41.92 APE12-dist-in 13.714 APE11-dist-in 11.852 APE10-dist-in 6.818 APE9-dist-in 3.361 K965R TPO893 TPO893 XRAY 3.42 0.187 0.213 H 344 330 0 0 0 0 [[727, 1020]] 1.0 8bu3 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU5E Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 6.942 15.122 None -123.64, -63.66 -81.97, -51.09 56.28, 22.54 292.49, 98.9 -91.33, -28.22 in-out in 8.371 Saltbr-out 3.622 HRD-in -72.77, -54.57 74.45, -4.91 out-in-out SNCoio in-out ActLoopNT-in 2.759 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -134.16, -27.33 APE9-dihe-na -98.05, 157.33 APE8-dihe-in -51.55, 136.25 APE8-rot-in 308.17 APE67-dihe-in -63.16, -26.85 -49.17, -41.17 APE12-dist-out 14.125 APE11-dist-in 12.168 APE10-dist-in 7.286 APE9-dist-in 3.726 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 E 344 331 0 0 0 0 [[727, 1020]] 1.0 8bu5 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU6B Q9NYV4 715 1039 1490.0 RQE:61101 Type1 Inactive DFGin 6.977 15.009 None -127.82, -64.26 -87.77, 91.87 -89.24, 20.45 288.89, 72.08 -65.57, -40.39 in-in in 8.424 Saltbr-in 3.481 HRD-in -70.61, -57.84 77.83, -2.42 in-in-out SNCiio in-out ActLoopNT-in 3.122 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.14, -54.56 APE9-dihe-na -81.61, 149.37 APE8-dihe-in -53.79, 145.32 APE8-rot-out 74.18 APE67-dihe-in -56.42, -37.71 -55.03, -39.62 APE12-dist-in 13.927 APE11-dist-in 11.784 APE10-dist-in 6.969 APE9-dist-in 3.408 K965R TPO893 TPO893 XRAY 3.45 0.219 0.249 B 344 325 0 0 0 0 [[727, 1020]] 1.0 8bu6 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU6H Q9NYV4 715 1038 1490.0 RQE:61101 Type1 Inactive DFGin 6.859 15.228 None -123.73, -80.29 -80.87, 99.66 -87.02, 20.65 285.61, 58.62 -65.39, -44.16 in-out in 8.422 Saltbr-out 5.096 HRD-in -73.68, -57.19 78.4, -0.7 out-in-out SNCoio in-out ActLoopNT-in 3.086 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.54, -53.3 APE9-dihe-na -74.55, 153.16 APE8-dihe-in -53.11, 139.67 APE8-rot-out 166.86 APE67-dihe-in -53.97, -35.01 -57.57, -41.34 APE12-dist-in 13.136 APE11-dist-in 12.428 APE10-dist-in 7.02 APE9-dist-in 3.421 K965R TPO893 TPO893 XRAY 3.45 0.219 0.249 H 344 324 0 0 0 0 [[727, 1020]] 1.0 8bu6 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BU9B Q9NYV4 715 1039 1490.0 RRC:61101 Type1 Inactive DFGin 6.895 15.55 None -126.5, -98.68 -52.95, 118.93 -112.03, 20.69 280.85, 78.53 -65.13, -14.55 in-in in 8.033 Saltbr-in 3.462 HRD-in -71.08, -52.06 74.5, 2.49 in-in-out SNCiio in-out ActLoopNT-in 3.038 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.03, -51.01 APE9-dihe-na -76.4, 148.49 APE8-dihe-in -61.77, 145.89 APE8-rot-out 190.86 APE67-dihe-in -62.1, -33.32 -50.51, -38.53 APE12-dist-in 13.262 APE11-dist-in 11.785 APE10-dist-in 6.5 APE9-dist-in 3.578 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 B 344 325 0 0 0 0 [[727, 1020]] 1.0 8bu9 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUBH Q9NYV4 715 1044 1490.0 RNU:61102 Type1 Inactive DFGin 7.264 15.677 None -126.03, -25.89 -87.61, 72.88 -91.51, 12.82 280.63, 73.67 -60.75, -39.82 in-in in 8.482 Saltbr-in 3.553 HRD-out -79.78, 93.25 -67.97, -38.17 in-out-out SNCioo out-out ActLoopNT-out 3.72 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iiii APE10-dihe-na -109.56, -9.94 APE9-dihe-na -106.55, 22.31 APE8-dihe-out 64.82, 23.4 APE8-rot-out 71.99 APE67-dihe-out -104.68, -30.69 71.46, -1.72 APE12-dist-in 12.711 APE11-dist-in 12.093 APE10-dist-in 6.861 APE9-dist-in 4.598 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 H 344 330 0 0 0 0 [[727, 1020]] 1.0 8bub Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUCH Q9NYV4 715 1044 1490.0 RKO:61101 Type1 Inactive DFGin 6.938 15.242 None -126.85, -64.01 -88.43, 98.06 -96.23, 24.88 287.21, 69.27 -75.34, -9.66 in-in in 7.946 Saltbr-in 3.3 HRD-in -84.47, -51.91 75.61, -7.74 in-in-in SNCiii in-in ActLoopNT-in 2.979 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.44, -52.72 APE9-dihe-na -81.82, 150.47 APE8-dihe-in -58.85, 136.79 APE8-rot-in 300.83 APE67-dihe-in -60.33, -38.14 -49.32, -40.23 APE12-dist-in 13.762 APE11-dist-in 11.782 APE10-dist-in 6.973 APE9-dist-in 3.26 K965R TPO893 TPO893 XRAY 3.85 0.183 0.224 H 344 330 0 0 0 0 [[727, 1020]] 1.0 8buc Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUEB Q9NYV4 715 1043 1490.0 RVU:61101 Type1 Inactive DFGin 6.876 15.6 None -134.01, -59.19 -81.95, 94.22 -92.57, 38.59 286.02, 76.0 -80.72, -24.77 in-in in 7.932 Saltbr-in 2.987 HRD-in -72.56, -56.91 77.87, 2.52 in-in-out SNCiio in-out ActLoopNT-in 2.904 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.91, -27.24 APE9-dihe-na -111.61, 155.18 APE8-dihe-in -59.11, 144.49 APE8-rot-out 174.63 APE67-dihe-in -64.14, -33.78 -56.66, -36.69 APE12-dist-in 13.229 APE11-dist-in 11.575 APE10-dist-in 6.84 APE9-dist-in 3.733 K965R TPO893 TPO893 XRAY 3.25 0.186 0.213 B 344 329 0 0 0 0 [[727, 1020]] 1.0 8bue Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUFB Q9NYV4 715 1033 1490.0 RW6:61101 Type1 Inactive DFGin 6.905 15.636 None -129.93, -62.21 -79.23, 97.53 -95.7, 37.47 286.05, 76.01 -76.9, -21.74 in-in in 8.105 Saltbr-in 3.153 HRD-in -72.11, -52.31 75.51, 2.58 in-in-out SNCiio in-out ActLoopNT-in 2.886 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.68, -63.24 APE9-dihe-na -77.98, 146.57 APE8-dihe-in -61.93, 149.44 APE8-rot-out 186.78 APE67-dihe-in -61.63, -31.53 -53.67, -39.8 APE12-dist-in 13.17 APE11-dist-in 10.994 APE10-dist-in 6.59 APE9-dist-in 3.55 K965R TPO893 TPO893 XRAY 3.3 0.185 0.22 B 344 319 0 0 0 0 [[727, 1020]] 1.0 8buf Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUFH Q9NYV4 715 1032 1490.0 RW6:61101 Type1 Inactive DFGin 7.117 15.505 None -129.62, -58.72 -84.56, 91.07 -93.16, 33.34 286.36, 76.3 -77.96, -20.03 in-out in 8.147 Saltbr-out 3.733 HRD-in -74.59, -54.27 72.47, 1.47 out-in-in SNCoii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.36, -62.78 APE9-dihe-na -81.18, 153.72 APE8-dihe-in -60.4, 148.16 APE8-rot-in 306.45 APE67-dihe-in -63.34, -32.17 -56.22, -41.31 APE12-dist-in 13.717 APE11-dist-in 11.792 APE10-dist-in 7.061 APE9-dist-in 3.378 K965R TPO893 TPO893 XRAY 3.3 0.185 0.22 H 344 318 0 0 0 0 [[727, 1020]] 1.0 8buf Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUGB Q9NYV4 715 1041 1490.0 RPW:61101 Type1 Inactive DFGin 6.885 15.532 None -132.35, -51.84 -89.28, 88.82 -91.59, 19.28 282.49, 80.64 -62.07, -38.03 in-in in 8.034 Saltbr-in 2.912 HRD-in -62.84, -54.31 70.37, 7.41 in-in-out SNCiio in-out ActLoopNT-in 3.001 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -68.25, -47.63 APE9-dihe-na -75.15, 151.02 APE8-dihe-in -63.11, 148.71 APE8-rot-out 182.54 APE67-dihe-in -62.59, -33.17 -53.62, -43.42 APE12-dist-in 12.503 APE11-dist-in 11.813 APE10-dist-in 6.379 APE9-dist-in 3.619 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 B 344 327 0 0 0 0 [[727, 1020]] 1.0 8bug Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUHB Q9NYV4 715 1039 1490.0 RR9:61101 Type1 Inactive DFGin 7.179 15.539 None -138.13, -51.2 -84.38, 89.05 -94.33, 22.38 291.72, 70.83 -65.07, -27.18 in-in in 8.156 Saltbr-in 3.17 HRD-in -65.3, -52.38 69.31, 6.78 in-in-out SNCiio in-out ActLoopNT-in 2.918 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -73.08, -42.42 APE9-dihe-na -75.03, 155.7 APE8-dihe-in -68.77, 151.86 APE8-rot-out 184.25 APE67-dihe-in -61.51, -37.69 -56.24, -40.88 APE12-dist-in 12.3 APE11-dist-in 11.985 APE10-dist-in 6.197 APE9-dist-in 3.673 K965R TPO893 TPO893 XRAY 3.79 0.189 0.232 B 344 325 0 0 0 0 [[727, 1020]] 1.0 8buh Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUHH Q9NYV4 715 1033 1490.0 RR9:61101 Type1 Inactive DFGin 6.887 15.22 None -138.17, -50.63 -86.02, 83.59 -88.15, 19.63 292.55, 71.89 -63.06, -22.61 in-in in 8.184 Saltbr-in 2.943 HRD-in -66.24, -47.16 69.47, -1.27 in-in-out SNCiio in-out ActLoopNT-in 3.045 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -73.8, -40.23 APE9-dihe-na -75.94, 158.01 APE8-dihe-in -67.45, 146.95 APE8-rot-out 179.42 APE67-dihe-in -59.63, -39.48 -58.91, -41.72 APE12-dist-in 13.23 APE11-dist-in 12.468 APE10-dist-in 6.767 APE9-dist-in 3.376 K965R TPO893 TPO893 XRAY 3.79 0.189 0.232 H 344 319 0 0 0 0 [[727, 1020]] 1.0 8buh Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUJB Q9NYV4 715 1041 1490.0 RUW:1101 Type1 Inactive DFGin 6.983 15.2 None -129.99, -57.9 -94.94, 86.34 -84.73, 29.33 287.08, 75.1 -66.06, -25.85 in-in in 7.864 Saltbr-in 2.946 HRD-in -63.86, -54.33 75.41, -2.11 in-in-out SNCiio in-out ActLoopNT-in 3.063 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -117.09, -50.74 APE9-dihe-na -90.83, 154.53 APE8-dihe-in -64.5, 148.14 APE8-rot-out 189.98 APE67-dihe-in -60.8, -34.01 -57.18, -38.53 APE12-dist-in 13.262 APE11-dist-in 11.425 APE10-dist-in 7.106 APE9-dist-in 3.522 K965R TPO893 TPO893 XRAY 3.62 0.164 0.206 B 344 327 0 0 0 0 [[727, 1020]] 1.0 8buj Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUJH Q9NYV4 715 1043 1490.0 RUW:1101 Type1 Inactive DFGin 6.896 15.077 None -125.46, -61.45 -96.84, 87.36 -85.01, 26.05 287.54, 74.01 -66.36, -25.41 in-in in 7.813 Saltbr-in 3.01 HRD-in -63.78, -55.47 74.76, -1.95 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.8, -48.82 APE9-dihe-na -90.4, 155.44 APE8-dihe-in -63.14, 147.75 APE8-rot-in 306.89 APE67-dihe-in -59.19, -33.71 -59.17, -40.93 APE12-dist-in 13.546 APE11-dist-in 11.437 APE10-dist-in 6.901 APE9-dist-in 3.454 K965R TPO893 TPO893 XRAY 3.62 0.164 0.206 H 344 329 0 0 0 0 [[727, 1020]] 1.0 8buj Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUKB Q9NYV4 715 1040 1490.0 RWE:61101 Type1 Inactive DFGin 6.868 15.185 None -136.79, -63.9 -86.16, 95.92 -96.18, 34.75 292.05, 70.82 -73.05, -21.93 in-in in 7.997 Saltbr-in 2.896 HRD-in -70.18, -56.12 75.44, 6.36 in-in-in SNCiii in-in ActLoopNT-in 2.951 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.1, -51.8 APE9-dihe-na -97.16, 156.72 APE8-dihe-in -60.0, 144.72 APE8-rot-in 296.0 APE67-dihe-in -62.91, -30.64 -55.4, -37.75 APE12-dist-in 13.344 APE11-dist-in 11.495 APE10-dist-in 7.221 APE9-dist-in 3.634 K965R TPO893 TPO893 XRAY 3.41 0.186 0.21 B 344 326 0 0 0 0 [[727, 1020]] 1.0 8buk Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUKH Q9NYV4 715 1044 1490.0 RWE:61101 Type1 Inactive DFGin 6.839 15.247 None -132.41, -70.3 -85.48, 98.43 -94.85, 32.62 289.18, 70.32 -75.66, -23.83 in-in in 8.084 Saltbr-in 3.087 HRD-in -67.86, -57.14 74.14, 6.98 in-in-out SNCiio in-out ActLoopNT-in 2.886 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -102.71, -45.22 APE9-dihe-na -97.3, 156.39 APE8-dihe-in -62.45, 146.81 APE8-rot-out 169.98 APE67-dihe-in -63.55, -31.48 -56.16, -39.65 APE12-dist-in 13.689 APE11-dist-in 11.797 APE10-dist-in 7.13 APE9-dist-in 3.728 K965R TPO893 TPO893 XRAY 3.41 0.186 0.21 H 344 330 0 0 0 0 [[727, 1020]] 1.0 8buk Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BULB Q9NYV4 715 1039 1490.0 RSU:1101 Type1 Inactive DFGin 7.048 15.572 None -134.15, -61.62 -82.15, 93.36 -91.03, 19.31 284.15, 82.25 -57.36, -30.14 in-in in 7.938 Saltbr-in 2.929 HRD-in -70.64, -53.34 75.97, 4.36 in-in-in SNCiii in-in ActLoopNT-in 3.117 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.1, -23.33 APE9-dihe-na -106.91, 152.49 APE8-dihe-in -59.59, 141.04 APE8-rot-in 301.22 APE67-dihe-in -61.09, -37.16 -52.97, -42.84 APE12-dist-in 13.298 APE11-dist-in 11.607 APE10-dist-in 6.723 APE9-dist-in 3.608 None TPO893 TPO893 XRAY 3.4 0.179 0.215 B 344 325 0 0 0 0 [[727, 1020]] 1.0 8bul Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUMB Q9NYV4 715 1040 1490.0 T6X:1101 Type1 Inactive DFGin 6.864 15.665 None -134.73, -83.5 -67.29, 93.27 -90.11, 26.53 284.48, 75.06 -65.26, -28.59 in-in in 7.994 Saltbr-in 3.485 HRD-in -65.89, -56.24 77.66, 6.87 in-in-in SNCiii in-in ActLoopNT-in 3.127 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.13, -38.62 APE9-dihe-na -95.11, 154.79 APE8-dihe-in -60.97, 148.11 APE8-rot-in 309.8 APE67-dihe-in -61.69, -36.7 -58.55, -38.83 APE12-dist-in 13.456 APE11-dist-in 11.598 APE10-dist-in 6.67 APE9-dist-in 3.667 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 B 344 326 0 0 0 0 [[727, 1020]] 1.0 8bum Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUMH Q9NYV4 715 1039 1490.0 T6X:1101 Type1 Inactive DFGin 7.024 15.457 None -135.37, -57.05 -84.79, 89.46 -91.01, 22.09 287.95, 72.46 -66.77, -30.21 in-out in 8.068 Saltbr-out 4.131 HRD-in -66.21, -56.87 75.95, 5.67 out-in-in SNCoii in-in ActLoopNT-in 2.955 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.45, -40.59 APE9-dihe-na -95.46, 155.5 APE8-dihe-in -61.11, 150.0 APE8-rot-in 312.75 APE67-dihe-in -61.06, -36.71 -56.48, -41.62 APE12-dist-in 13.625 APE11-dist-in 11.736 APE10-dist-in 7.168 APE9-dist-in 3.579 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 H 344 325 0 0 0 0 [[727, 1020]] 1.0 8bum Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUOH Q9NYV4 715 1044 1490.0 RLC:1101 Type1 Inactive DFGin 6.953 15.267 None -133.0, -52.84 -89.06, 92.6 -92.03, 19.54 286.01, 76.31 -65.14, -29.67 in-in in 8.196 Saltbr-in 3.289 HRD-in -68.8, -55.72 77.31, -13.16 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.5, -30.39 APE9-dihe-na -96.1, 151.94 APE8-dihe-in -61.51, 140.45 APE8-rot-in 333.9 APE67-dihe-in -58.03, -34.02 -53.9, -41.38 APE12-dist-in 13.549 APE11-dist-in 11.791 APE10-dist-in 6.766 APE9-dist-in 3.358 K965R TPO893 TPO893 XRAY 3.58 0.179 0.219 H 344 330 0 0 0 0 [[727, 1020]] 1.0 8buo Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUQH Q9NYV4 715 1035 1490.0 RQ9:61101 Type1 Inactive DFGin 6.847 15.413 None -139.0, -68.9 -74.65, 86.14 -87.77, 25.62 285.6, 75.05 -68.98, -27.88 in-in in 8.141 Saltbr-in 3.342 HRD-in -71.56, -55.82 75.32, -0.25 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.77, -46.85 APE9-dihe-na -88.37, 155.15 APE8-dihe-in -63.62, 147.91 APE8-rot-out 74.55 APE67-dihe-in -59.91, -28.34 -56.29, -43.5 APE12-dist-in 13.706 APE11-dist-in 11.98 APE10-dist-in 7.059 APE9-dist-in 3.543 K965R TPO893 TPO893 XRAY 3.2 0.196 0.216 H 344 321 0 0 0 0 [[727, 1020]] 1.0 8buq Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BURH Q9NYV4 715 1039 1490.0 RQU:61101 Type1 Inactive DFGin 6.774 15.444 None -128.98, -68.65 -83.3, 94.14 -94.27, 19.71 289.32, 85.87 -66.64, -31.92 in-in in 8.145 Saltbr-in 2.879 HRD-in -62.95, -51.76 69.51, 6.54 in-in-out SNCiio in-out ActLoopNT-in 3.108 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -119.35, -54.64 APE9-dihe-na -87.35, 151.65 APE8-dihe-in -60.57, 144.24 APE8-rot-out 76.95 APE67-dihe-in -62.32, -33.37 -50.2, -40.95 APE12-dist-in 13.743 APE11-dist-in 11.662 APE10-dist-in 7.086 APE9-dist-in 3.671 K965R TPO893 TPO893 XRAY 3.64 0.192 0.234 H 344 325 0 0 0 0 [[727, 1020]] 1.0 8bur Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 8BUSE Q9NYV4 715 1043 1490.0 RMX:1101 Type1 Inactive DFGin 6.726 15.869 None -132.84, -50.43 -84.41, 82.25 -87.45, 22.35 281.7, 77.83 -63.73, -33.79 in-in in 8.158 Saltbr-in 3.282 HRD-in -70.71, -48.94 71.36, 12.53 in-in-out SNCiio in-out ActLoopNT-in 2.996 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -96.11, -47.21 APE9-dihe-na -97.32, 150.19 APE8-dihe-in -67.32, 151.1 APE8-rot-out 195.8 APE67-dihe-in -58.67, -27.66 -56.54, -42.34 APE12-dist-in 13.285 APE11-dist-in 11.393 APE10-dist-in 7.34 APE9-dist-in 3.456 K965R TPO893 TPO893 XRAY 3.26 0.209 0.228 E 344 329 0 0 0 0 [[727, 1020]] 1.0 8bus Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CDK12_HUMAN 9FMRB Q9NYV4 714 1047 1490.0 RMF:61101 Type1 Inactive DFGin 7.124 15.031 None -111.49, -74.26 -77.99, -72.15 68.85, 12.84 296.16, 89.8 -66.22, -36.51 in-out in 8.332 Saltbr-out 4.45 HRD-in -70.8, -35.56 62.81, 1.22 out-in-in SNCoii in-in ActLoopNT-in 3.072 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.03, -25.75 APE9-dihe-na -103.56, 146.88 APE8-dihe-in -51.72, 138.27 APE8-rot-in 305.58 APE67-dihe-in -69.51, -21.36 -53.61, -35.19 APE12-dist-in 13.987 APE11-dist-in 12.27 APE10-dist-in 7.331 APE9-dist-in 3.865 None TPO893 TPO893 XRAY 3.9 0.209 0.25 B 351 334 0 0 0 0 [[727, 1020]] 1.0 9fmr Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

CMGC_CDK12 (Cyclin-dependent kinase 12)

Total number of chains: 0
Active chains: 0
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name