Protein kinases in complex with DKI

Total number of genes: 8
Total number of chains: 9
Spatial Dihedral Chains Representative
DFGin BLAminus 5 2WU6A
DFGin BLBminus 1 4AAAA
DFGinter None 2 3HMIA
None None 1 2W4OA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
CAMK CAMK4 KCC4_HUMAN Calcium/calmodulin-dependent protein kinase type IV 2W4OA 2.17 Inactive None None none-none none-out DKI Type1
CK1 CSNK1G3 KC1G3_HUMAN Casein kinase I isoform gamma-3 2CHLA 1.95 Active DFGin BLAminus in-in in-in DKI Type1
CMGC CDKL2 CDKL2_HUMAN Cyclin-dependent kinase-like 2 4AAAA 1.53 Inactive DFGin BLBminus out-none none-out DKI Type1
CMGC CLK3 CLK3_HUMAN Dual specificity protein kinase CLK3 2WU6A 1.92 Active DFGin BLAminus in-in in-in DKI Type1
STE SLK SLK_HUMAN STE20-like serine/threonine-protein kinase 2J51A 2.1 Inactive DFGin BLAminus in-out in-out DKI Type1
STE SLK SLK_HUMAN STE20-like serine/threonine-protein kinase 2JFLA 2.2 Inactive DFGin BLAminus in-out in-out DKI Type1
STE STK24 STK24_HUMAN Serine/threonine-protein kinase 24 4QMPA 2.0 Active DFGin BLAminus in-in in-in DKI Type1
STE STK26 STK26_HUMAN Serine/threonine-protein kinase 26 4FZFB 3.64 Inactive DFGinter None out-out out-out DKI Type1
TYR ABL2 ABL2_HUMAN Tyrosine-protein kinase ABL2 3HMIA 1.65 Inactive DFGinter None in-in out-in DKI Type1

Protein kinases in complex with DKI

Total number of genes: 9
Total number of chains: 11
Spatial Dihedral Chains Representative
DFGin BLAminus 7 2WU6A
DFGin BLBminus 1 4AAAA
DFGinter None 2 3HMIA
None None 1 2W4OA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens CAMK CAMK4 KCC4_HUMAN Calcium/calmodulin-dependent protein kinase type IV 2W4OA 2.17 Inactive None None none-none none-out DKI Type1
Homo sapiens CK1 CSNK1G3 KC1G3_HUMAN Casein kinase I isoform gamma-3 2CHLA 1.95 Active DFGin BLAminus in-in in-in DKI Type1
Homo sapiens CMGC CDKL2 CDKL2_HUMAN Cyclin-dependent kinase-like 2 4AAAA 1.53 Inactive DFGin BLBminus out-none none-out DKI Type1
Homo sapiens CMGC CLK3 CLK3_HUMAN Dual specificity protein kinase CLK3 2WU6A 1.92 Active DFGin BLAminus in-in in-in DKI Type1
Homo sapiens STE SLK SLK_HUMAN STE20-like serine/threonine-protein kinase 2J51A 2.1 Inactive DFGin BLAminus in-out in-out DKI Type1
Homo sapiens STE SLK SLK_HUMAN STE20-like serine/threonine-protein kinase 2JFLA 2.2 Inactive DFGin BLAminus in-out in-out DKI Type1
Homo sapiens STE STK24 STK24_HUMAN Serine/threonine-protein kinase 24 4QMPA 2.0 Active DFGin BLAminus in-in in-in DKI Type1
Homo sapiens STE STK26 STK26_HUMAN Serine/threonine-protein kinase 26 4FZFB 3.64 Inactive DFGinter None out-out out-out DKI Type1
Homo sapiens TYR ABL2 ABL2_HUMAN Tyrosine-protein kinase ABL2 3HMIA 1.65 Inactive DFGinter None in-in out-in DKI Type1
Saccharomyces cerevisiae OTHER IRE1 IRE1_YEAST Serine/threonine-protein kinase/endoribonuclease IRE1 3LJ1A 3.33 None DFGin BLAminus in-in in-none DKI Type1
Saccharomyces cerevisiae OTHER IRE1 IRE1_YEAST Serine/threonine-protein kinase/endoribonuclease IRE1 3LJ1B 3.33 None DFGin BLAminus in-in in-none DKI Type1

Protein kinases in complex with DKI

Total number of genes: 1
Total number of chains: 2
Spatial Dihedral Chains Representative
DFGin BLAminus 2 3LJ1A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Saccharomyces cerevisiae OTHER IRE1 IRE1_YEAST Serine/threonine-protein kinase/endoribonuclease IRE1 3LJ1A 3.33 None DFGin BLAminus in-in in-none DKI Type1
Saccharomyces cerevisiae OTHER IRE1 IRE1_YEAST Serine/threonine-protein kinase/endoribonuclease IRE1 3LJ1B 3.33 None DFGin BLAminus in-in in-none DKI Type1