IRE1 (Serine/threonine-protein kinase/endoribonuclease IRE1)

No human structures known.

IRE1 (Serine/threonine-protein kinase/endoribonuclease IRE1)

Group: OTHER
Total number of chains: 43
Spatial Dihedral Chains Representative
DFGin BLAminus 41 3FBVA
DFGin ABAminus 2 3LJ2A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Saccharomyces cerevisiae IRE1_YEAST 3LJ2A 3.33 Inactive DFGin ABAminus in-in in-none IZA Type1 665 - 1115 None X840,X841,X844 7
Saccharomyces cerevisiae IRE1_YEAST 3LJ2B 3.33 Inactive DFGin ABAminus in-in in-none IZA Type1 665 - 1115 None X840,X841,X844 7
Saccharomyces cerevisiae IRE1_YEAST 3SDMA 6.6 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDMB 6.6 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDMC 6.6 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDMD 6.6 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDME 6.6 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDMF 6.6 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDMG 6.6 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVA 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVB 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVC 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVD 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 663 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVE 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVF 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVG 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVH 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVI 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 672 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVJ 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 672 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVK 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 663 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVL 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVM 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVN 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJA 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJB 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJC 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJD 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 663 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJE 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJF 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJG 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJH 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJI 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 672 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJJ 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 672 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJK 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 663 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJL 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJM 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJN 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 2RIOA 2.4 None DFGin BLAminus out-in in-none ADP Type1 665 - 1115 None None 14
Saccharomyces cerevisiae IRE1_YEAST 2RIOB 2.4 None DFGin BLAminus in-in in-none ADP Type1 665 - 1115 None None 14
Saccharomyces cerevisiae IRE1_YEAST 3LJ1A 3.33 None DFGin BLAminus in-in in-none DKI Type1 665 - 1115 None X840,X841,X844 7
Saccharomyces cerevisiae IRE1_YEAST 3LJ1B 3.33 None DFGin BLAminus in-in in-none DKI Type1 665 - 1115 None X840,X841,X844 7
Saccharomyces cerevisiae IRE1_YEAST 3LJ0A 3.2 None DFGin BLAminus in-in in-none ADP QUE Type1 Allosteric 665 - 1115 None X840,X841,X844 7
Saccharomyces cerevisiae IRE1_YEAST 3LJ0B 3.2 None DFGin BLAminus in-in in-none ADP QUE Type1 Allosteric 670 - 1115 None X840,X841,X844 7

IRE1 (Serine/threonine-protein kinase/endoribonuclease IRE1)

Group: OTHER
Total number of chains: 43
Spatial Dihedral Chains Representative
DFGin BLAminus 41 3FBVA
DFGin ABAminus 2 3LJ2A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Saccharomyces cerevisiae IRE1_YEAST 3LJ2A 3.33 Inactive DFGin ABAminus in-in in-none IZA Type1 665 - 1115 None X840,X841,X844 7
Saccharomyces cerevisiae IRE1_YEAST 3LJ2B 3.33 Inactive DFGin ABAminus in-in in-none IZA Type1 665 - 1115 None X840,X841,X844 7
Saccharomyces cerevisiae IRE1_YEAST 3SDMA 6.6 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDMB 6.6 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDMC 6.6 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDMD 6.6 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDME 6.6 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDMF 6.6 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDMG 6.6 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVA 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVB 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVC 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVD 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 663 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVE 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVF 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVG 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVH 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVI 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 672 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVJ 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 672 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVK 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 663 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVL 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVM 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3FBVN 3.2 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 None X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJA 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJB 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJC 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJD 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 663 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJE 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJF 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJG 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJH 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJI 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 672 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJJ 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 672 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJK 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 663 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJL 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJM 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 3SDJN 3.65 Inactive DFGin BLAminus in-in in-out APJ Type1 670 - 1115 H1061N X840,X841,X844 0
Saccharomyces cerevisiae IRE1_YEAST 2RIOA 2.4 None DFGin BLAminus out-in in-none ADP Type1 665 - 1115 None None 14
Saccharomyces cerevisiae IRE1_YEAST 2RIOB 2.4 None DFGin BLAminus in-in in-none ADP Type1 665 - 1115 None None 14
Saccharomyces cerevisiae IRE1_YEAST 3LJ1A 3.33 None DFGin BLAminus in-in in-none DKI Type1 665 - 1115 None X840,X841,X844 7
Saccharomyces cerevisiae IRE1_YEAST 3LJ1B 3.33 None DFGin BLAminus in-in in-none DKI Type1 665 - 1115 None X840,X841,X844 7
Saccharomyces cerevisiae IRE1_YEAST 3LJ0A 3.2 None DFGin BLAminus in-in in-none ADP QUE Type1 Allosteric 665 - 1115 None X840,X841,X844 7
Saccharomyces cerevisiae IRE1_YEAST 3LJ0B 3.2 None DFGin BLAminus in-in in-none ADP QUE Type1 Allosteric 670 - 1115 None X840,X841,X844 7