CLK3 (Dual specificity protein kinase CLK3)

Group: CMGC
Uniprot: CLK3_HUMAN
Domain boundary: 304 - 620


Total number of chains: 28
Spatial Dihedral Chains Representative
DFGin BLAminus 26 AF-P49761-K1A
DFGout None 1 9EZ3A
None None 1 2EXEA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P49761-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 296 - 628 None None 0
2EU9A 1.53 Active DFGin BLAminus in-in in-in No_ligand No_ligand 136 - 481 None None 0
6FT7A 2.02 Active DFGin BLAminus in-in in-in E6Q Type1 129 - 484 None None 0
6FT7B 2.02 Active DFGin BLAminus in-in in-in E6Q Type1 129 - 484 None None 0
6RCTA 2.32 Active DFGin BLAminus in-in in-in JWN Type1 135 - 484 None None 0
6RCTB 2.32 Active DFGin BLAminus in-in in-in JWN Type1 134 - 484 None None 0
6YTWA 2.0 Active DFGin BLAminus in-in in-in EAE Type1 127 - 481 None None 0
6YTWB 2.0 Active DFGin BLAminus in-in in-in EAE Type1 134 - 481 None None 0
6YU1a 1.9 Active DFGin BLAminus in-in in-in KHC Type1 135 - 481 None None 0
6YU1c 1.9 Active DFGin BLAminus in-in in-in KHC Type1 127 - 481 None None 0
6Z51A 1.92 Active DFGin BLAminus in-in in-in Q8B Type1 134 - 484 None None 0
6Z52A 2.12 Active DFGin BLAminus in-in in-in Q8T Type1 129 - 482 None None 0
6Z52B 2.12 Active DFGin BLAminus in-in in-in Q8T Type1 129 - 482 None None 0
6Z53A 1.65 Active DFGin BLAminus in-in in-in Q7Z Type1 134 - 484 None None 0
6Z54A 1.73 Active DFGin BLAminus in-in in-in Q7H Type1 134 - 484 None None 0
6Z55A 1.7 Active DFGin BLAminus in-in in-in PQ5 Type1 127 - 482 None None 0
6Z55B 1.7 Active DFGin BLAminus in-in in-in PQ5 Type1 128 - 484 None None 0
6FYPA 2.29 Active DFGin BLAminus in-in in-in 3NG Type1 135 - 482 None None 0
6FYRA 1.42 Active DFGin BLAminus in-in in-in EAQ Type1 128 - 482 None None 0
2WU6A 1.92 Active DFGin BLAminus in-in in-in DKI Type1 134 - 483 None None 0
2WU7A 2.25 Active DFGin BLAminus in-in in-in V25 Type1 135 - 482 None None 0
3RAWA 2.09 Active DFGin BLAminus in-in in-in 3RA Type1 134 - 484 None None 0
3RAWB 2.09 Active DFGin BLAminus in-in in-in 3RA Type1 136 - 484 None None 0
6YTYA 1.76 Active DFGin BLAminus in-in in-in EAE Type1 127 - 481 A319V None 0
6Z2VA 2.6 Active DFGin BLAminus in-in in-in KHC Type1 134 - 480 A319V None 0
6KHFA 2.598 Active DFGin BLAminus in-in in-in 3NG Type1 142 - 481 None None 0
9EZ3A 2.7 Inactive DFGout None in-in none-in A1H74 Type2 136 - 481 None None 11
2EXEA 2.35 Inactive None None none-none in-in No_ligand No_ligand 198 - 479 None None 0

CLK3 (Dual specificity protein kinase CLK3)

Group: CMGC
Total number of chains: 29
Spatial Dihedral Chains Representative
DFGin BLAminus 27 AF-P49761-K1A
DFGout None 1 9EZ3A
None None 1 2EXEA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens CLK3_HUMAN AF-P49761-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 296 - 628 None None 0
Homo sapiens CLK3_HUMAN 2EU9A 1.53 Active DFGin BLAminus in-in in-in No_ligand No_ligand 136 - 481 None None 0
Homo sapiens CLK3_HUMAN 6FT7A 2.02 Active DFGin BLAminus in-in in-in E6Q Type1 129 - 484 None None 0
Homo sapiens CLK3_HUMAN 6FT7B 2.02 Active DFGin BLAminus in-in in-in E6Q Type1 129 - 484 None None 0
Homo sapiens CLK3_HUMAN 6RCTA 2.32 Active DFGin BLAminus in-in in-in JWN Type1 135 - 484 None None 0
Homo sapiens CLK3_HUMAN 6RCTB 2.32 Active DFGin BLAminus in-in in-in JWN Type1 134 - 484 None None 0
Homo sapiens CLK3_HUMAN 6YTWA 2.0 Active DFGin BLAminus in-in in-in EAE Type1 127 - 481 None None 0
Homo sapiens CLK3_HUMAN 6YTWB 2.0 Active DFGin BLAminus in-in in-in EAE Type1 134 - 481 None None 0
Homo sapiens CLK3_HUMAN 6YU1a 1.9 Active DFGin BLAminus in-in in-in KHC Type1 135 - 481 None None 0
Homo sapiens CLK3_HUMAN 6YU1c 1.9 Active DFGin BLAminus in-in in-in KHC Type1 127 - 481 None None 0
Homo sapiens CLK3_HUMAN 6Z51A 1.92 Active DFGin BLAminus in-in in-in Q8B Type1 134 - 484 None None 0
Homo sapiens CLK3_HUMAN 6Z52A 2.12 Active DFGin BLAminus in-in in-in Q8T Type1 129 - 482 None None 0
Homo sapiens CLK3_HUMAN 6Z52B 2.12 Active DFGin BLAminus in-in in-in Q8T Type1 129 - 482 None None 0
Homo sapiens CLK3_HUMAN 6Z53A 1.65 Active DFGin BLAminus in-in in-in Q7Z Type1 134 - 484 None None 0
Homo sapiens CLK3_HUMAN 6Z54A 1.73 Active DFGin BLAminus in-in in-in Q7H Type1 134 - 484 None None 0
Homo sapiens CLK3_HUMAN 6Z55A 1.7 Active DFGin BLAminus in-in in-in PQ5 Type1 127 - 482 None None 0
Homo sapiens CLK3_HUMAN 6Z55B 1.7 Active DFGin BLAminus in-in in-in PQ5 Type1 128 - 484 None None 0
Homo sapiens CLK3_HUMAN 6FYPA 2.29 Active DFGin BLAminus in-in in-in 3NG Type1 135 - 482 None None 0
Homo sapiens CLK3_HUMAN 6FYRA 1.42 Active DFGin BLAminus in-in in-in EAQ Type1 128 - 482 None None 0
Homo sapiens CLK3_HUMAN 2WU6A 1.92 Active DFGin BLAminus in-in in-in DKI Type1 134 - 483 None None 0
Homo sapiens CLK3_HUMAN 2WU7A 2.25 Active DFGin BLAminus in-in in-in V25 Type1 135 - 482 None None 0
Homo sapiens CLK3_HUMAN 3RAWA 2.09 Active DFGin BLAminus in-in in-in 3RA Type1 134 - 484 None None 0
Homo sapiens CLK3_HUMAN 3RAWB 2.09 Active DFGin BLAminus in-in in-in 3RA Type1 136 - 484 None None 0
Homo sapiens CLK3_HUMAN 6YTYA 1.76 Active DFGin BLAminus in-in in-in EAE Type1 127 - 481 A319V None 0
Homo sapiens CLK3_HUMAN 6Z2VA 2.6 Active DFGin BLAminus in-in in-in KHC Type1 134 - 480 A319V None 0
Homo sapiens CLK3_HUMAN 6KHFA 2.598 Active DFGin BLAminus in-in in-in 3NG Type1 142 - 481 None None 0
Homo sapiens CLK3_HUMAN 9EZ3A 2.7 Inactive DFGout None in-in none-in A1H74 Type2 136 - 481 None None 11
Homo sapiens CLK3_HUMAN 2EXEA 2.35 Inactive None None none-none in-in No_ligand No_ligand 198 - 479 None None 0
Plasmodium falciparum UGT5.1 W7JM86_PLAFA 8RPCA 2.079 Active DFGin BLAminus in-in in-in A1H19 Type1 40 - 396 None X228 0

CLK3 (Dual specificity protein kinase CLK3)

Group: CMGC
Total number of chains: 1
Spatial Dihedral Chains Representative
DFGin BLAminus 1 8RPCA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Plasmodium falciparum UGT5.1 W7JM86_PLAFA 8RPCA 2.079 Active DFGin BLAminus in-in in-in A1H19 Type1 40 - 396 None X228 0