2GMX

MAPK8 (Mitogen-activated protein kinase 8)
Group: CMGC
Uniprot: MK08_HUMAN
Organism: Homo sapiens
Domain boundary: 26 - 321
Resolu: 3.5

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in 877 Type1 8 - 364 0
B Inactive DFGin None in-out in-in 877 Type1 7 - 364 0
Representative sequence - Chain B
10 20 30 40
msrskrDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV
50 60 70 80
CAAYDAILER NVAIKKLSRP FQNQTHAKRA YRELVLMKCV
90 100 110 120
NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ
130 140 150 160
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK
170 180 190 200
SDCTLKILDF GLARTAGTSF MMEPEVVTRY YRAPEVILGM
210 220 230 240
GYKENVDLWS VGCIMGEMVC HKILFPGRDY IDQWNKVIEQ
250 260 270 280
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF
290 300 310 320
PADSEHNKLK ASQARDLLSK MLVIDASKRI SVDEALQHPY
330 340 350 360
INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV
-
MDLEhhhhhh
Lower-case residues are disordered in structure.
Mutations: T183E,Y185E
Phosphorylation: None