2XS0

MAPK8 (Mitogen-activated protein kinase 8)
Group: CMGC
Uniprot: MK08_HUMAN
Organism: Homo sapiens
Domain boundary: 26 - 321
Resolu: 2.6

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus in-out none-none ANP Type1 6 - 365 14
Representative sequence - Chain A
8 18 28 38
gsmsrskRDN NFYSVEIGDS TFTVLKRYQN LKPIGSGAQG
48 58 68 78
IVCAAYDAIL ERNVAIKKLS RPFQNQTHAK RAYRELVLMK
88 98 108 118
CVNHKNIIGL LNVFTPQKSL EEFQDVYIVM ELMDANLCQV
128 138 148 158
IQMELDHERM SYLLYQMLCG IKHLHSAGII HRDLKPSNIV
168 178 188 198
VKSDCTLKIL DFGLArtagt sfmmvpfvvT RYYRAPEVIL
208 218 228 238
GMGYKENVDI WSVGCIMGEM IKGGVLFPGT DHIDQWNKVI
248 258 268 278
EQLGTPCPEF MKKLQPTVRT YVENRPKYAG YSFEKLFPDV
288 298 308 318
LFPADSEHNK LKASQARDLL SKMLVIDASK RISVDEALQH
328 338 348 358
PYINVWYDPS EAEAPPPKIP DKQLDEREHT IEEWKELIYK
368 378
EVMDLEErtk ngvirgqpsp laqvqq
Lower-case residues are disordered in structure.
Mutations: T183V,Y185F
Phosphorylation: None