4L7F

MAPK8 (Mitogen-activated protein kinase 8)
Group: CMGC
Uniprot: MK08_HUMAN
Organism: Homo sapiens
Domain boundary: 26 - 321
Resolu: 1.95

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus in-in none-out 1V5 Type1 7 - 362 13
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
        14         24         34         44 
SLDNNFYSVE IGDSTFTVLK RYQNLKPIGS GAQGIVCAAY 
        54         64         74         84 
DAILERNVAI KKLSRPFQNQ THAKRAYREL VLMKCVNHKN 
        94        104        114        124 
IIGLLNVFTP QKSLEEFQDV YIVMELMDAN LCQVIQMELD 
       134        144        154        164 
HERMSYLLYQ MLCGIKHLHS AGIIHRDLKP SNIVVKSDCT 
       174        184        194        204 
LKILDFGLar tagtsfmmtp yVVTRYYRAP EVILGMGYKE 
       214        224        234        244 
NVDLWSVGCI MGEMVCHKIL FPGRDYIDQW NKVIEQLGTP 
       254        264        274        284 
CPEFMKKLQP TVRTYVENRP KYAGYSFEKL FPDVLFPADS 
       294        304        314        324 
EHNKLKASQA RDLLSKMLVI DASKRISVDE ALQHPYINVW 
       334        344        354          - 
YDPSEAEAPP PKIPDKQLDE REHTIEEWKE LIYKEVMDWR 

KGIITIT
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None