Ligand: Q6K

Total number of chains: 16
Active chains: 6
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 8 50.0% 6Z4BA
DFGin BLAminus 6 37.5% 9BY4A
DFGin BLBtrans 2 12.5% 9GDVB
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Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR EGFR EGFR_HUMAN 9BY6A 2.551 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PDO, Q6K Allosteric, Type1 698 - 1009 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9BY4A 2.307 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PDO, Q6K, PDO, PDO Allosteric, Type1, Allosteric, Type1 696 - 1010 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LGSA 3.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai Q6K Type1 702 - 984 0 None V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LGSB 3.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai Q6K Type1 702 - 984 0 None V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LGSC 3.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai Q6K Type1 701 - 984 0 None V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LGSD 3.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai Q6K Type1 701 - 984 0 None V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6XL4A 2.06 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai Q6K, NQ1 Type1, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GK5A 2.3 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao Q6K, YW5 Type1, Type3 701 - 1011 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GK5B 2.3 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai Q6K, YW5 Type1, Type3 700 - 1008 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GK5C 2.3 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao Q6K, YW5 Type1, Type3 700 - 1008 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GK5D 2.3 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_niiai APEdist_aaai Q6K, YW5 Type1, Type3 700 - 1008 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6Z4BA 2.5 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_niiai APEdist_aaao Q6K, 9LL Type1, Type3 700 - 982 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6Z4BB 2.5 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao Q6K, 9LL Type1, Type3 699 - 984 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6XL4B 2.06 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai NQ1, Q6K Type3, Type1 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9GDVA 2.218 Inactive DFGin‑BLBtrans out-none out-none TYR APEdihe_nniai APEdist_aaai Q6K Type1 702 - 985 0 None V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9GDVB 2.218 Inactive DFGin‑BLBtrans out-none none-out TYR APEdihe_nniai APEdist_aaao Q6K Type1 702 - 985 0 None V948R Epidermal growth factor receptor

Ligand: Q6K

Total number of chains: 16
Active chains: 6
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 8 50.0% 6Z4BA
DFGin BLAminus 6 37.5% 9BY4A
DFGin BLBtrans 2 12.5% 9GDVB
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR EGFR EGFR_HUMAN 9BY6A 2.551 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PDO, Q6K Allosteric, Type1 698 - 1009 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 9BY4A 2.307 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PDO, Q6K, PDO, PDO Allosteric, Type1, Allosteric, Type1 696 - 1010 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7LGSA 3.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai Q6K Type1 702 - 984 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7LGSB 3.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai Q6K Type1 702 - 984 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7LGSC 3.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai Q6K Type1 701 - 984 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7LGSD 3.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai Q6K Type1 701 - 984 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6XL4A 2.06 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai Q6K, NQ1 Type1, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8GK5A 2.3 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao Q6K, YW5 Type1, Type3 701 - 1011 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8GK5B 2.3 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai Q6K, YW5 Type1, Type3 700 - 1008 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8GK5C 2.3 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao Q6K, YW5 Type1, Type3 700 - 1008 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8GK5D 2.3 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_niiai APEdist_aaai Q6K, YW5 Type1, Type3 700 - 1008 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6Z4BA 2.5 Inactive DFGin‑BLBplus out-none out-out TYR APEdihe_niiai APEdist_aaao Q6K, 9LL Type1, Type3 700 - 982 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6Z4BB 2.5 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao Q6K, 9LL Type1, Type3 699 - 984 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6XL4B 2.06 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai NQ1, Q6K Type3, Type1 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 9GDVA 2.218 Inactive DFGin‑BLBtrans out-none out-none TYR APEdihe_nniai APEdist_aaai Q6K Type1 702 - 985 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 9GDVB 2.218 Inactive DFGin‑BLBtrans out-none none-out TYR APEdihe_nniai APEdist_aaao Q6K Type1 702 - 985 0 None V948R Epidermal growth factor receptor Homo sapiens

Ligand: Q6K

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism