Ligand: PDO

Total number of chains: 5
Active chains: 2
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 60.0% 9BY4A
DFGout BBAminus 1 20.0% 9CJ3A
DFGout None 1 20.0% 9CJ5A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK AURKA AURKA_HUMAN 8SSPA O14965 126 389 403.0 PDO:507,627:510 Allosteric,Type1 Inactive DFGin 5.827 16.097 BLAminus -128.28, -176.57 55.06, 88.12 -104.67, 28.54 279.82, 74.62 -68.31, -32.7 out-out out 10.408 Saltbr-out 5.122 HRD-in -77.88, -49.99 65.51, 20.52 out-in-in SNCoii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.81, 156.13 APE9-dihe-na 124.75, -152.05 APE8-dihe-in -113.82, 146.04 APE8-rot-in 319.01 APE67-dihe-in -74.25, -9.45 -51.04, -52.82 APE12-dist-in 10.214 APE11-dist-in 11.164 APE10-dist-in 5.569 APE9-dist-in 3.598 None None None XRAY 2.6 0.202 0.257 A 284 264 0 0 0 0 [[133, 383]] 1.0 8ssp CAMK_AURKA_HUMAN CAMK 7.6e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CMGC MAPK14 MK14_HUMAN 9CJ3A Q16539 4 352 360.0 PDO:408,A1AWV:410 Allosteric,Type2 Inactive DFGout 15.273 9.306 BBAminus -138.7, -172.72 -146.54, 104.28 -50.46, -45.96 262.7, 81.94 68.22, 25.32 in-in in 8.498 Saltbr-in 2.829 HRD-in -69.96, -52.7 76.88, -14.52 in-out-out SNCioo out-out ActLoopNT-out 16.534 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -126.47, 117.16 APE9-dihe-na -77.09, 129.32 APE8-dihe-out -52.48, -42.5 APE8-rot-in 292.76 APE67-dihe-in -62.21, -22.05 -58.1, -28.96 APE12-dist-out 14.763 APE11-dist-in 12.851 APE10-dist-out 12.749 APE9-dist-out 10.318 None TPO180,PTR182 TPO180,PTR182 XRAY 1.95 0.144 0.189 A 360 344 5 0 0 5 [[24, 308]] 1.0 9cj3 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9CJ5A Q16539 5 352 360.0 A1AWV:404,PDO:405 Type2,Allosteric Inactive DFGout 15.604 9.946 None -161.07, 167.42 -158.02, 105.92 -133.23, 63.25 67.22, 124.33 -54.97, -26.0 in-in in 8.697 Saltbr-in 2.767 HRD-in -81.64, -51.08 76.49, -58.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -113.44, 119.12 APE9-dihe-na -66.71, 142.75 APE8-dihe-out -74.59, -35.87 APE8-rot-in 303.87 APE67-dihe-in -57.3, -25.76 -59.56, -25.3 APE12-dist-none 999.0 APE11-dist-out 14.245 APE10-dist-out 15.033 APE9-dist-out 11.806 None None None XRAY 3.3 0.247 0.276 A 360 334 11 0 0 6 [[24, 308]] 1.0 9cj5 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
TYR EGFR EGFR_HUMAN 9BY6A P00533 698 1009 1210.0 PDO:1301,Q6K:1302 Allosteric,Type1 Active DFGin 6.002 15.663 BLAminus -149.77, -168.8 56.86, 79.46 -96.38, 24.13 296.36, 92.05 -63.66, -24.81 in-in in 9.063 Saltbr-in 3.491 HRD-in -75.7, -50.64 70.26, 5.13 in-in-in SNCiii in-in ActLoopNT-in 2.955 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.71, 133.19 APE9-dihe-in -133.13, 146.74 APE8-dihe-in -72.35, 102.77 APE8-rot-na 25.41 APE67-dihe-in -79.34, -8.97 -76.98, -28.96 APE12-dist-na 12.695 APE11-dist-na 9.472 APE10-dist-na 11.091 APE9-dist-in 6.657 None None None XRAY 2.551 0.208 0.245 A 338 311 1 0 0 0 [[712, 970]] 1.0 9by6 TYR_EGFR_HUMAN TYR 1.2e-87 299.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9BY4A P00533 696 1010 1210.0 PDO:61301,Q6K:61302,PDO:61304,PDO:61305 Allosteric,Type1,Allosteric,Type1 Active DFGin 6.118 15.558 BLAminus -131.58, -170.69 55.04, 91.41 -104.93, 32.17 291.61, 87.59 -69.69, -25.35 in-in in 8.748 Saltbr-in 2.724 HRD-in -74.22, -51.47 72.05, 2.77 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.0, 133.58 APE9-dihe-in -140.48, 146.73 APE8-dihe-in -77.28, 98.44 APE8-rot-na 2.83 APE67-dihe-in -69.73, -13.67 -59.81, -44.15 APE12-dist-na 11.983 APE11-dist-na 10.159 APE10-dist-na 10.796 APE9-dist-in 6.63 None None None XRAY 2.307 0.197 0.22 A 338 315 0 0 0 0 [[712, 970]] 1.0 9by4 TYR_EGFR_HUMAN TYR 1.2e-87 299.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: PDO

Total number of chains: 6
Active chains: 2
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 50.0% 9BY4A
DFGin BLBminus 1 16.7% 4L68A
DFGout BBAminus 1 16.7% 9CJ3A
DFGout None 1 16.7% 9CJ5A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
OTHER BIR2 BIR2_ARATH 4L68A Q9LSI9 272 600 605.0 PDO:60701 Allosteric Pseudo DFGin 9.12 13.554 BLBminus -102.75, 164.19 78.08, 3.07 -61.21, 134.13 312.77, 999.0 84.79, -0.01 out-out out 13.782 Saltbr-out 15.36 HRD-in -67.43, -47.03 75.0, -5.42 out-out-out SNCooo out-out ActLoopNT-out 5.938 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nioi APE10-dihe-na -95.05, 4.01 APE9-dihe-na 129.54, -165.7 APE8-dihe-in -116.84, 144.73 APE8-rot-na 179.81 APE67-dihe-inflip 91.69, -13.11 -52.03, 129.52 APE12-dist-none 999.0 APE11-dist-in 11.902 APE10-dist-out 15.357 APE9-dist-in 3.82 None None None XRAY 2.0 0.191 0.213 A 340 313 16 0 0 11 [[306, 577]] 1.0 4l68 Arabidopsis thaliana OTHER_BIR2_ARATH TKL 2.4e-44 157.9 4 266 263 446 447 448 450 452 335 350 354 426 428 427 429 490 478 473 472 471 470 469 468 467 380 Inactive LRR receptor-like serine/threonine-protein kinase BIR2
CAMK AURKA AURKA_HUMAN 8SSPA O14965 126 389 403.0 PDO:507,627:510 Allosteric,Type1 Inactive DFGin 5.827 16.097 BLAminus -128.28, -176.57 55.06, 88.12 -104.67, 28.54 279.82, 74.62 -68.31, -32.7 out-out out 10.408 Saltbr-out 5.122 HRD-in -77.88, -49.99 65.51, 20.52 out-in-in SNCoii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.81, 156.13 APE9-dihe-na 124.75, -152.05 APE8-dihe-in -113.82, 146.04 APE8-rot-in 319.01 APE67-dihe-in -74.25, -9.45 -51.04, -52.82 APE12-dist-in 10.214 APE11-dist-in 11.164 APE10-dist-in 5.569 APE9-dist-in 3.598 None None None XRAY 2.6 0.202 0.257 A 284 264 0 0 0 0 [[133, 383]] 1.0 8ssp Homo sapiens CAMK_AURKA_HUMAN CAMK 7.6e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CMGC MAPK14 MK14_HUMAN 9CJ3A Q16539 4 352 360.0 PDO:408,A1AWV:410 Allosteric,Type2 Inactive DFGout 15.273 9.306 BBAminus -138.7, -172.72 -146.54, 104.28 -50.46, -45.96 262.7, 81.94 68.22, 25.32 in-in in 8.498 Saltbr-in 2.829 HRD-in -69.96, -52.7 76.88, -14.52 in-out-out SNCioo out-out ActLoopNT-out 16.534 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -126.47, 117.16 APE9-dihe-na -77.09, 129.32 APE8-dihe-out -52.48, -42.5 APE8-rot-in 292.76 APE67-dihe-in -62.21, -22.05 -58.1, -28.96 APE12-dist-out 14.763 APE11-dist-in 12.851 APE10-dist-out 12.749 APE9-dist-out 10.318 None TPO180,PTR182 TPO180,PTR182 XRAY 1.95 0.144 0.189 A 360 344 5 0 0 5 [[24, 308]] 1.0 9cj3 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9CJ5A Q16539 5 352 360.0 A1AWV:404,PDO:405 Type2,Allosteric Inactive DFGout 15.604 9.946 None -161.07, 167.42 -158.02, 105.92 -133.23, 63.25 67.22, 124.33 -54.97, -26.0 in-in in 8.697 Saltbr-in 2.767 HRD-in -81.64, -51.08 76.49, -58.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -113.44, 119.12 APE9-dihe-na -66.71, 142.75 APE8-dihe-out -74.59, -35.87 APE8-rot-in 303.87 APE67-dihe-in -57.3, -25.76 -59.56, -25.3 APE12-dist-none 999.0 APE11-dist-out 14.245 APE10-dist-out 15.033 APE9-dist-out 11.806 None None None XRAY 3.3 0.247 0.276 A 360 334 11 0 0 6 [[24, 308]] 1.0 9cj5 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
TYR EGFR EGFR_HUMAN 9BY6A P00533 698 1009 1210.0 PDO:1301,Q6K:1302 Allosteric,Type1 Active DFGin 6.002 15.663 BLAminus -149.77, -168.8 56.86, 79.46 -96.38, 24.13 296.36, 92.05 -63.66, -24.81 in-in in 9.063 Saltbr-in 3.491 HRD-in -75.7, -50.64 70.26, 5.13 in-in-in SNCiii in-in ActLoopNT-in 2.955 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.71, 133.19 APE9-dihe-in -133.13, 146.74 APE8-dihe-in -72.35, 102.77 APE8-rot-na 25.41 APE67-dihe-in -79.34, -8.97 -76.98, -28.96 APE12-dist-na 12.695 APE11-dist-na 9.472 APE10-dist-na 11.091 APE9-dist-in 6.657 None None None XRAY 2.551 0.208 0.245 A 338 311 1 0 0 0 [[712, 970]] 1.0 9by6 Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-87 299.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9BY4A P00533 696 1010 1210.0 PDO:61301,Q6K:61302,PDO:61304,PDO:61305 Allosteric,Type1,Allosteric,Type1 Active DFGin 6.118 15.558 BLAminus -131.58, -170.69 55.04, 91.41 -104.93, 32.17 291.61, 87.59 -69.69, -25.35 in-in in 8.748 Saltbr-in 2.724 HRD-in -74.22, -51.47 72.05, 2.77 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.0, 133.58 APE9-dihe-in -140.48, 146.73 APE8-dihe-in -77.28, 98.44 APE8-rot-na 2.83 APE67-dihe-in -69.73, -13.67 -59.81, -44.15 APE12-dist-na 11.983 APE11-dist-na 10.159 APE10-dist-na 10.796 APE9-dist-in 6.63 None None None XRAY 2.307 0.197 0.22 A 338 315 0 0 0 0 [[712, 970]] 1.0 9by4 Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-87 299.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: PDO

Total number of chains: 1
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 1 100.0% 4L68A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
OTHER BIR2 BIR2_ARATH 4L68A Q9LSI9 272 600 605.0 PDO:60701 Allosteric Pseudo DFGin 9.12 13.554 BLBminus -102.75, 164.19 78.08, 3.07 -61.21, 134.13 312.77, 999.0 84.79, -0.01 out-out out 13.782 Saltbr-out 15.36 HRD-in -67.43, -47.03 75.0, -5.42 out-out-out SNCooo out-out ActLoopNT-out 5.938 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nioi APE10-dihe-na -95.05, 4.01 APE9-dihe-na 129.54, -165.7 APE8-dihe-in -116.84, 144.73 APE8-rot-na 179.81 APE67-dihe-inflip 91.69, -13.11 -52.03, 129.52 APE12-dist-none 999.0 APE11-dist-in 11.902 APE10-dist-out 15.357 APE9-dist-in 3.82 None None None XRAY 2.0 0.191 0.213 A 340 313 16 0 0 11 [[306, 577]] 1.0 4l68 Arabidopsis thaliana OTHER_BIR2_ARATH TKL 2.4e-44 157.9 4 266 263 446 447 448 450 452 335 350 354 426 428 427 429 490 478 473 472 471 470 469 468 467 380 Inactive LRR receptor-like serine/threonine-protein kinase BIR2