Ligand: LU8

Total number of chains: 100
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 90 90.0% 6SRHB
DFGout None 10 10.0% 8XFYA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYA 3.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo A1LU8 Type1 58 - 358 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYB 3.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 59 - 358 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYC 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nooo A1LU8 Type1 61 - 358 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYD 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 63 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYE 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooi A1LU8 Type1 64 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYF 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 63 - 345 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYG 3.2 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_nooi A1LU8 Type1 59 - 346 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYH 3.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nooi A1LU8 Type1 59 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYI 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 63 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYJ 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nooi A1LU8 Type1 65 - 347 0 None None Ribosomal protein S6 kinase alpha-3
TKL ACVR1 ACVR1_HUMAN 5S7QB 1.53 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi XJM, LU8, XJM Allosteric, Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S77B 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S78B 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 208 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S79B 1.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 208 - 498 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7GB 1.78 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8 Type1 207 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7HB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7JB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 206 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7PB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 208 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7WB 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S83B 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S84B 1.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 206 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S89B 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6SRHA 1.25 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 201 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7BB 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XH7 Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7CB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, T5Y Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7DB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XHD Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7EB 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XEA Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7KB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XEJ Type1, Allosteric 205 - 499 0 None None Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7MB 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, HVK Type1, Allosteric 208 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7NB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, 2AI Type1, Allosteric 207 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7SB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, 09V Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7VB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XH1 Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7XB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LGA Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7ZB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, BYZ Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S82B 1.71 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LU8, LAC Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S86B 1.31 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LU8, XK7 Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S87B 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XKD Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S88B 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XKS Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S8AB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XKY Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S75B 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, HUH, HUH Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S79A 1.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7AB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, T5V, T5V Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7EA 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7FA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7FB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XH4, XH4 Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7GA 1.78 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 498 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7OA 1.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7QA 1.53 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7UA 1.59 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7UB 1.59 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iioi LU8, XGY, XGY Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7VA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7WA 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7YA 1.37 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S80A 1.67 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S80B 1.67 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XGM, XGM Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S82A 1.71 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S87A 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S88A 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S9KA 1.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6SRHB 1.25 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S77A 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, BAQ Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7DA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XHD Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7JA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, XHG Type1, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7KA 1.31 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8, LU8, LU8, XEJ Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None None Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7LA 1.36 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, XHJ Type1, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7MA 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, HVK, HVK Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7NA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, 2AI Type1, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7PA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, V1L Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7SA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, 09V Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7TB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XGJ, XGJ, XGJ Type1, Allosteric, Allosteric, Allosteric 205 - 498 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7XA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, LGA Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S86A 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XK7 Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S89A 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XKV Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S8AA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XKY Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S8BB 1.64 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XFV, XFV, XFV Type1, Allosteric, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S75A 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, HUH, HUH Type1, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7AA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, T5V, T5V Type1, Allosteric, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7BA 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oioi LU8, LU8, LU8, XH7, XH7 Type1, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7HA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, HVB, HVB Type1, Allosteric, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7ZA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, BYZ, BYZ Type1, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S81B 1.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XJV, XJV, XJV, XJV Type1, Allosteric, Allosteric, Allosteric, Allosteric 208 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7CA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, T5Y, T5Y, T5Y Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7IA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, HV2, HV2, HV2 Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7TA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XGJ, XGJ, XGJ Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7YB 1.37 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XJP, XJP, XJP, XJP, XJP Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 207 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7RB 1.46 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XGS, XGS, XGS, XGS, XGS, XGS Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S85A 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XK4, XK4, XK4, XK4 Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S8BA 1.64 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XFV, XFV, XFV, XFV Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7RA 1.46 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XGS, XGS, XGS, XGS, XGS Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7IB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, HV2, HV2, HV2, HV2, HV2, HV2, HV2, HV2, HV2 Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S78A 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, XGV, XGV, XGV Type1, Allosteric, Allosteric, Allosteric, Allosteric, Type1 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S81A 1.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XJV, XJV Type1, Allosteric, Allosteric, Allosteric, Type1 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S76A 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, 02A, 02A Type1, Allosteric, Allosteric, Allosteric, Type1.5_Back 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7LB 1.36 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XHJ, XHJ, XHJ, XHJ Type1, Allosteric, Allosteric, Allosteric, Type3 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S84A 1.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XK1 Type1, Allosteric, Allosteric, Type1 201 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S83A 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XJY Type1, Allosteric, Allosteric, Type3 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7OB 1.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XJJ Type1, Type1 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S85B 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XK4, XK4, XK4 Type1, Type1, Allosteric, Allosteric 207 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S76B 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, 02A Type1, Type1.5_Back 205 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S9KB 1.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, YV4 Type1, Type3 205 - 499 0 None Q207D Activin receptor type-1

Ligand: LU8

Total number of chains: 100
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 90 90.0% 6SRHB
DFGout None 10 10.0% 8XFYA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYA 3.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo A1LU8 Type1 58 - 358 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYB 3.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 59 - 358 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYC 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nooo A1LU8 Type1 61 - 358 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYD 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 63 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYE 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooi A1LU8 Type1 64 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYF 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 63 - 345 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYG 3.2 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_nooi A1LU8 Type1 59 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYH 3.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nooi A1LU8 Type1 59 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYI 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 63 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYJ 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nooi A1LU8 Type1 65 - 347 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7QB 1.53 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi XJM, LU8, XJM Allosteric, Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S77B 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S78B 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 208 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S79B 1.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 208 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7GB 1.78 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8 Type1 207 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7HB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7JB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 206 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7PB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 208 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7WB 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S83B 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S84B 1.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 206 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S89B 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 6SRHA 1.25 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8 Type1 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7BB 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XH7 Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7CB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, T5Y Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7DB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XHD Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7EB 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XEA Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7KB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XEJ Type1, Allosteric 205 - 499 0 None None Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7MB 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, HVK Type1, Allosteric 208 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7NB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, 2AI Type1, Allosteric 207 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7SB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, 09V Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7VB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XH1 Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7XB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LGA Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7ZB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, BYZ Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S82B 1.71 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LU8, LAC Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S86B 1.31 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii LU8, XK7 Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S87B 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XKD Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S88B 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XKS Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S8AB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XKY Type1, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S75B 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, HUH, HUH Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S79A 1.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7AB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, T5V, T5V Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7EA 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7FA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7FB 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XH4, XH4 Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7GA 1.78 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7OA 1.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7QA 1.53 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7UA 1.59 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7UB 1.59 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iioi LU8, XGY, XGY Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7VA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7WA 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7YA 1.37 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S80A 1.67 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S80B 1.67 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XGM, XGM Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S82A 1.71 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S87A 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S88A 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S9KA 1.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 6SRHB 1.25 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8 Type1, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S77A 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, BAQ Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7DA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XHD Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7JA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, XHG Type1, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7KA 1.31 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii LU8, LU8, LU8, XEJ Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None None Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7LA 1.36 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, XHJ Type1, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7MA 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, HVK, HVK Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7NA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, 2AI Type1, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7PA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, V1L Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7SA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, 09V Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7TB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XGJ, XGJ, XGJ Type1, Allosteric, Allosteric, Allosteric 205 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7XA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, LGA Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S86A 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XK7 Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S89A 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XKV Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S8AA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XKY Type1, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S8BB 1.64 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XFV, XFV, XFV Type1, Allosteric, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S75A 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, HUH, HUH Type1, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7AA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, T5V, T5V Type1, Allosteric, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7BA 1.32 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oioi LU8, LU8, LU8, XH7, XH7 Type1, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7HA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, HVB, HVB Type1, Allosteric, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7ZA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, BYZ, BYZ Type1, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S81B 1.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XJV, XJV, XJV, XJV Type1, Allosteric, Allosteric, Allosteric, Allosteric 208 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7CA 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, T5Y, T5Y, T5Y Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7IA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, HV2, HV2, HV2 Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7TA 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XGJ, XGJ, XGJ Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7YB 1.37 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XJP, XJP, XJP, XJP, XJP Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 207 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7RB 1.46 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XGS, XGS, XGS, XGS, XGS, XGS Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S85A 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XK4, XK4, XK4, XK4 Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S8BA 1.64 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XFV, XFV, XFV, XFV Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7RA 1.46 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XGS, XGS, XGS, XGS, XGS Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7IB 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, HV2, HV2, HV2, HV2, HV2, HV2, HV2, HV2, HV2 Type1, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric, Allosteric 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S78A 1.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, LU8, LU8, XGV, XGV, XGV Type1, Allosteric, Allosteric, Allosteric, Allosteric, Type1 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S81A 1.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XJV, XJV Type1, Allosteric, Allosteric, Allosteric, Type1 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S76A 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, 02A, 02A Type1, Allosteric, Allosteric, Allosteric, Type1.5_Back 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7LB 1.36 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XHJ, XHJ, XHJ, XHJ Type1, Allosteric, Allosteric, Allosteric, Type3 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S84A 1.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XK1 Type1, Allosteric, Allosteric, Type1 201 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S83A 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi LU8, LU8, LU8, XJY Type1, Allosteric, Allosteric, Type3 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S7OB 1.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XJJ Type1, Type1 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S85B 1.33 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, XK4, XK4, XK4 Type1, Type1, Allosteric, Allosteric 207 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S76B 1.31 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, 02A Type1, Type1.5_Back 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 5S9KB 1.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi LU8, YV4 Type1, Type3 205 - 499 0 None Q207D Activin receptor type-1 Homo sapiens

Ligand: LU8

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism