Ligand: LU8

Total number of chains: 100
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 90 90.0% 6SRHB
DFGout None 10 10.0% 8XFYA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYA P51812 58 358 740.0 A1LU8:401 Type1 Inactive DFGout 13.2049 7.3468 None -84.69, 175.04 -98.49, -2.97 -56.06, -41.49 288.51, 111.93 -88.04, -1.58 out-out out 13.584 Saltbr-out 12.4908 HRD-out -102.98, 108.87 -62.66, -66.03 out-out-out SNCooo out-out ActLoopNT-out 5.2899 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -171.34, 174.53 APE9-dihe-na 132.9, 150.52 APE8-dihe-in -54.44, 119.7 APE8-rot-in 325.6 APE67-dihe-in -67.51, -35.24 -72.39, -24.23 APE12-dist-none 999.0 APE11-dist-out 15.3012 APE10-dist-out 13.362 APE9-dist-out 6.3968 None None None XRAY 3.2 0.233 0.303 A 320.0 289.0 12 28 19 9 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYB P51812 59 358 740.0 A1LU8:401 Type1 Inactive DFGout 12.4755 7.6225 None -79.21, 172.69 -104.74, 14.38 -72.96, -37.65 288.72, 121.74 -83.1, -14.53 out-out out 13.02 Saltbr-out 10.2513 HRD-out -85.11, 105.26 -64.66, -55.07 out-out-out SNCooo out-out ActLoopNT-out 5.1807 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -141.21, 158.45 APE9-dihe-na 119.59, 160.83 APE8-dihe-in -64.8, 132.56 APE8-rot-out 38.16 APE67-dihe-in -76.3, -33.52 -81.38, -10.91 APE12-dist-none 999.0 APE11-dist-out 15.9119 APE10-dist-out 12.4271 APE9-dist-out 6.3691 None None None XRAY 3.2 0.233 0.303 B 320.0 277.0 23 28 18 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYC P51812 61 358 740.0 A1LU8:401 Type1 Inactive DFGout 13.0072 7.4047 None -74.08, -176.12 -117.42, 16.75 -70.92, -31.59 288.86, 115.13 -89.42, -33.94 none-none none 999.0 Saltbr-none 999.0 HRD-out -99.11, 116.77 -79.3, -60.22 none-out-out SNCnoo out-out ActLoopNT-out 5.1388 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -154.86, 91.8 APE9-dihe-na -163.03, 159.53 APE8-dihe-in -69.77, 116.03 APE8-rot-in 309.84 APE67-dihe-in -63.05, -25.35 -70.36, -29.8 APE12-dist-none 999.0 APE11-dist-out 15.6924 APE10-dist-out 13.2566 APE9-dist-out 6.1853 None None None XRAY 3.2 0.233 0.303 C 320.0 272.0 26 28 18 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYD P51812 63 348 740.0 A1LU8:401 Type1 Inactive DFGout 12.6801 7.7179 None -85.23, 171.03 -99.91, 5.18 -66.56, -47.9 288.97, 119.73 -68.87, -42.49 none-none none 999.0 Saltbr-none 999.0 HRD-out -108.97, 107.04 -79.62, 147.57 none-out-out SNCnoo out-out ActLoopNT-out 5.0043 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -160.66, -177.37 APE9-dihe-na 101.82, 157.81 APE8-dihe-in -62.84, 132.59 APE8-rot-out 47.92 APE67-dihe-in -68.43, -26.54 -77.35, -22.1 APE12-dist-none 999.0 APE11-dist-out 16.0048 APE10-dist-out 13.6407 APE9-dist-out 7.2804 None None None XRAY 3.2 0.233 0.303 D 320.0 260.0 26 28 18 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYE P51812 64 348 740.0 A1LU8:401 Type1 Inactive DFGout 12.8137 7.7319 None -79.79, 173.69 -104.44, 5.05 -67.56, -37.65 296.33, 117.93 -76.73, -31.97 none-none none 999.0 Saltbr-none 999.0 HRD-out -107.95, 111.24 -79.69, -31.85 none-out-out SNCnoo out-out ActLoopNT-out 5.217 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooi APE10-dihe-na -171.13, 156.06 APE9-dihe-na 118.15, 155.77 APE8-dihe-in -55.33, 128.86 APE8-rot-out 36.52 APE67-dihe-in -70.55, -22.72 -79.46, -18.88 APE12-dist-none 999.0 APE11-dist-out 16.5561 APE10-dist-out 12.7625 APE9-dist-in 5.5786 None None None XRAY 3.2 0.233 0.303 E 320.0 261.0 24 28 19 9 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYF P51812 63 345 740.0 A1LU8:401 Type1 Inactive DFGout 12.7435 7.4714 None -95.59, -178.42 -108.18, 9.34 -70.41, -40.72 293.14, 115.72 -77.9, -28.8 none-none none 999.0 Saltbr-none 999.0 HRD-out -100.4, 115.65 -68.34, -48.2 none-out-out SNCnoo out-out ActLoopNT-out 5.1559 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -160.1, 173.9 APE9-dihe-na 114.4, 160.81 APE8-dihe-in -56.13, 119.9 APE8-rot-out 41.37 APE67-dihe-in -71.03, -16.28 -73.87, -18.19 APE12-dist-none 999.0 APE11-dist-out 15.3915 APE10-dist-out 13.539 APE9-dist-out 6.404 None None None XRAY 3.2 0.233 0.303 F 320.0 255.0 28 28 17 11 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYG P51812 59 346 740.0 A1LU8:401 Type1 Inactive DFGout 12.937 7.2256 None -78.16, 176.02 -98.19, 0.09 -62.25, -40.75 291.8, 111.06 -81.64, -19.61 in-out in 7.8808 Saltbr-out 5.486 HRD-out -91.07, 110.45 -88.21, -3.19 out-out-out SNCooo out-out ActLoopNT-out 5.1639 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -71.01, 158.33 APE9-dihe-na 129.65, 145.56 APE8-dihe-in -72.78, 126.88 APE8-rot-in 303.8 APE67-dihe-in -65.24, -40.51 -67.91, -29.47 APE12-dist-none 999.0 APE11-dist-out 16.1451 APE10-dist-out 12.0692 APE9-dist-in 4.6444 None None None XRAY 3.2 0.233 0.303 G 320.0 276.0 12 28 18 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYH P51812 59 348 740.0 A1LU8:401 Type1 Inactive DFGout 13.3745 7.7126 None -77.26, -179.45 -100.74, 0.21 -62.05, -41.28 291.33, 112.54 -80.3, -18.96 out-out out 12.403 Saltbr-out 7.8685 HRD-out -114.7, 107.73 -80.32, -3.28 out-out-out SNCooo out-out ActLoopNT-out 5.5612 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooi APE10-dihe-na -169.14, 166.07 APE9-dihe-na 97.31, 158.5 APE8-dihe-in -62.25, 138.33 APE8-rot-out 53.1 APE67-dihe-in -70.31, -30.08 -88.76, -15.85 APE12-dist-none 999.0 APE11-dist-out 15.6879 APE10-dist-out 12.1686 APE9-dist-in 5.1187 None None None XRAY 3.2 0.233 0.303 H 320.0 277.0 13 28 18 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYI P51812 63 348 740.0 A1LU8:401 Type1 Inactive DFGout 12.4851 7.3943 None -79.8, 178.19 -107.54, 4.76 -62.98, -39.18 294.19, 109.04 -76.4, -38.16 none-none none 999.0 Saltbr-none 999.0 HRD-out -110.77, 98.18 -69.66, 134.16 none-out-out SNCnoo out-out ActLoopNT-out 4.9415 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -128.64, 168.96 APE9-dihe-na 103.76, 142.33 APE8-dihe-in -52.02, 130.9 APE8-rot-out 52.96 APE67-dihe-in -63.86, -32.68 -78.41, -20.46 APE12-dist-none 999.0 APE11-dist-out 16.5462 APE10-dist-out 12.6058 APE9-dist-out 6.6092 None None None XRAY 3.2 0.233 0.303 I 320.0 260.0 26 28 18 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYJ P51812 65 347 740.0 A1LU8:401 Type1 Inactive DFGout 12.6806 7.2532 None -82.1, 175.26 -103.79, -3.59 -58.74, -48.51 291.22, 109.94 -83.23, -7.51 none-none none 999.0 Saltbr-none 999.0 HRD-out -111.91, 105.75 -75.45, -19.05 none-out-out SNCnoo out-out ActLoopNT-out 5.0033 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -112.59, 166.79 APE9-dihe-na 114.55, 148.33 APE8-dihe-in -68.28, 140.99 APE8-rot-in 305.08 APE67-dihe-in -73.95, -40.89 -90.2, -12.76 APE12-dist-none 999.0 APE11-dist-out 16.5618 APE10-dist-out 12.8633 APE9-dist-in 5.003 None None None XRAY 3.2 0.233 0.303 J 320.0 257.0 26 28 18 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
TKL ACVR1 ACVR1_HUMAN 5S7QB Q04771 205 499 509.0 XJM:1801,LU8:1802,XJM:1806 Allosteric,Type1,Allosteric Inactive DFGin 7.0354 13.341 BLAminus -124.49, 160.57 78.3, 88.59 -102.07, 16.77 299.19, 176.61 -55.48, -25.66 in-out in 8.6067 Saltbr-out 4.5008 HRD-in -84.23, -49.81 75.94, -2.06 out-in-out SNCoio in-out ActLoopNT-in 2.8845 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.81, 167.47 APE9-dihe-na -59.06, 164.28 APE8-dihe-in -59.12, 123.47 APE8-rot-in 303.32 APE67-dihe-in -63.13, -25.62 -55.86, -41.03 APE12-dist-in 10.2953 APE11-dist-out 6.5068 APE10-dist-out 8.8401 APE9-dist-in 3.7438 Q207D None None XRAY 1.53 0.209 0.243 B 301.0 291.0 4 32 32 0 [[207, 497]] 1.0 5s7q TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S77B Q04771 205 499 509.0 LU8:501 Type1 Inactive DFGin 7.0308 13.4527 BLAminus -124.57, 162.89 76.44, 87.16 -99.57, 19.41 300.08, 174.78 -68.76, -14.31 in-out in 8.8527 Saltbr-out 4.6527 HRD-in -77.29, -55.2 78.52, -0.63 out-in-out SNCoio in-out ActLoopNT-in 2.946 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.24, 166.6 APE9-dihe-na -61.81, 164.74 APE8-dihe-in -60.61, 127.64 APE8-rot-in 298.26 APE67-dihe-in -59.97, -28.12 -61.67, -40.13 APE12-dist-in 10.3703 APE11-dist-out 6.2089 APE10-dist-out 8.9958 APE9-dist-in 3.8238 Q207D None None XRAY 1.31 0.166 0.185 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s77 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S78B Q04771 208 499 509.0 LU8:501 Type1 Inactive DFGin 6.9916 13.4038 BLAminus -126.64, 164.14 74.77, 87.97 -101.18, 22.29 302.33, 177.25 -70.25, -15.52 in-out in 8.8007 Saltbr-out 4.6843 HRD-in -78.72, -53.62 78.73, -3.65 out-in-out SNCoio in-out ActLoopNT-in 2.9471 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.7, 165.64 APE9-dihe-na -61.72, 165.79 APE8-dihe-in -60.78, 129.07 APE8-rot-in 300.39 APE67-dihe-in -58.83, -27.2 -62.73, -40.71 APE12-dist-in 10.2054 APE11-dist-out 6.245 APE10-dist-out 9.0468 APE9-dist-in 3.86 Q207D None None XRAY 1.3 0.16 0.177 B 301.0 292.0 0 32 32 0 [[207, 497]] 1.0 5s78 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S79B Q04771 208 498 509.0 LU8:501 Type1 Inactive DFGin 6.949 13.4088 BLAminus -122.03, 163.17 76.24, 92.19 -103.59, 21.82 301.57, 173.56 -69.99, -14.55 in-out in 8.6068 Saltbr-out 3.7757 HRD-in -77.29, -54.6 79.65, 0.11 out-in-out SNCoio in-out ActLoopNT-in 2.9027 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -123.19, 173.51 APE9-dihe-na -67.77, 168.43 APE8-dihe-in -60.9, 124.36 APE8-rot-in 301.89 APE67-dihe-in -54.42, -27.95 -56.48, -46.08 APE12-dist-in 10.3631 APE11-dist-out 6.6445 APE10-dist-out 8.916 APE9-dist-in 3.7495 Q207D None None XRAY 1.5 0.18 0.206 B 301.0 288.0 3 32 32 0 [[207, 497]] 1.0 5s79 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7GB Q04771 207 499 509.0 LU8:501 Type1 Inactive DFGin 6.6407 13.4949 BLAminus -119.72, 159.88 82.75, 87.21 -98.63, 18.92 305.17, 0.99 -67.48, -19.33 in-out in 9.0173 Saltbr-out 4.9584 HRD-in -77.01, -50.93 75.96, 1.34 out-in-none SNCoin in-none ActLoopNT-in 2.9658 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -89.52, 148.19 APE9-dihe-na 117.39, 161.66 APE8-dihe-in -69.4, 128.02 APE8-rot-in 308.42 APE67-dihe-in -59.26, -33.51 -60.94, -38.65 APE12-dist-none 999.0 APE11-dist-in 11.6619 APE10-dist-in 5.8166 APE9-dist-in 3.9424 Q207D None None XRAY 1.78 0.206 0.252 B 301.0 281.0 12 32 24 8 [[207, 497]] 1.0 5s7g TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7HB Q04771 205 499 509.0 LU8:501 Type1 Inactive DFGin 7.002 13.3868 BLAminus -126.96, 163.26 76.81, 86.99 -100.87, 23.04 301.4, 176.52 -72.34, -14.12 in-out in 8.8346 Saltbr-out 4.7589 HRD-in -77.49, -53.08 77.02, -2.86 out-in-out SNCoio in-out ActLoopNT-in 2.9428 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.19, 165.21 APE9-dihe-na -62.02, 164.93 APE8-dihe-in -59.21, 129.08 APE8-rot-in 298.47 APE67-dihe-in -58.12, -30.1 -64.15, -39.55 APE12-dist-in 10.3133 APE11-dist-out 6.1622 APE10-dist-out 9.011 APE9-dist-in 3.7279 Q207D None None XRAY 1.3 0.158 0.18 B 301.0 293.0 2 32 32 0 [[207, 497]] 1.0 5s7h TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7JB Q04771 206 499 509.0 LU8:501 Type1 Inactive DFGin 6.9724 13.3899 BLAminus -125.59, 163.92 74.27, 89.45 -104.09, 21.89 302.89, 178.4 -70.85, -13.4 in-out in 8.7911 Saltbr-out 4.7228 HRD-in -74.57, -55.28 81.04, -2.31 out-in-out SNCoio in-out ActLoopNT-in 2.9444 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.08, 165.49 APE9-dihe-na -60.51, 165.0 APE8-dihe-in -60.32, 128.5 APE8-rot-in 300.26 APE67-dihe-in -54.83, -31.02 -61.2, -43.09 APE12-dist-in 10.3546 APE11-dist-out 6.1672 APE10-dist-out 9.0326 APE9-dist-in 3.8062 Q207D None None XRAY 1.31 0.159 0.181 B 301.0 291.0 3 32 32 0 [[207, 497]] 1.0 5s7j TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7PB Q04771 208 499 509.0 LU8:501 Type1 Inactive DFGin 7.041 13.4201 BLAminus -127.32, 160.61 79.2, 88.36 -101.38, 20.66 301.74, 174.56 -69.08, -14.59 in-out in 8.8375 Saltbr-out 4.7494 HRD-in -79.58, -51.94 76.5, -1.66 out-in-out SNCoio in-out ActLoopNT-in 2.9461 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.23, 166.15 APE9-dihe-na -60.81, 164.72 APE8-dihe-in -59.48, 128.85 APE8-rot-in 300.38 APE67-dihe-in -62.62, -25.57 -64.98, -36.96 APE12-dist-in 10.458 APE11-dist-out 6.1919 APE10-dist-out 8.9709 APE9-dist-in 3.8702 Q207D None None XRAY 1.31 0.158 0.176 B 301.0 289.0 3 32 32 0 [[207, 497]] 1.0 5s7p TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7WB Q04771 205 499 509.0 LU8:501 Type1 Inactive DFGin 7.0298 13.4008 BLAminus -127.76, 159.78 80.36, 85.76 -99.88, 21.09 305.52, 179.19 -65.9, -24.32 in-out in 8.9404 Saltbr-out 4.8194 HRD-in -77.42, -54.04 83.37, -7.62 out-in-out SNCoio in-out ActLoopNT-in 2.9581 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.09, 164.43 APE9-dihe-na -60.72, 165.96 APE8-dihe-in -63.25, 128.46 APE8-rot-in 296.55 APE67-dihe-in -59.57, -28.14 -60.1, -41.66 APE12-dist-in 10.3172 APE11-dist-out 6.2471 APE10-dist-out 9.0709 APE9-dist-in 3.8111 Q207D None None XRAY 1.33 0.164 0.186 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7w TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S83B Q04771 205 499 509.0 LU8:501 Type1 Inactive DFGin 7.0334 13.4784 BLAminus -124.19, 162.22 78.06, 86.57 -101.53, 19.96 300.51, 175.3 -64.11, -18.65 in-out in 8.8905 Saltbr-out 4.771 HRD-in -75.73, -55.05 82.15, -4.6 out-in-out SNCoio in-out ActLoopNT-in 2.9542 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.26, 164.39 APE9-dihe-na -61.1, 166.22 APE8-dihe-in -61.61, 128.13 APE8-rot-in 300.62 APE67-dihe-in -58.81, -29.24 -62.24, -41.18 APE12-dist-in 10.4236 APE11-dist-out 6.2854 APE10-dist-out 9.037 APE9-dist-in 3.8558 Q207D None None XRAY 1.33 0.161 0.185 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s83 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S84B Q04771 206 499 509.0 LU8:501 Type1 Inactive DFGin 6.9876 13.4478 BLAminus -125.42, 163.93 74.98, 89.22 -103.06, 18.19 302.78, 175.41 -63.64, -17.13 in-out in 8.8196 Saltbr-out 4.6677 HRD-in -75.34, -54.28 80.29, -2.12 out-in-out SNCoio in-out ActLoopNT-in 2.9161 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.41, 168.09 APE9-dihe-na -59.7, 163.97 APE8-dihe-in -58.67, 126.71 APE8-rot-in 301.06 APE67-dihe-in -57.69, -26.63 -61.25, -41.61 APE12-dist-in 10.3451 APE11-dist-out 6.2 APE10-dist-out 9.0135 APE9-dist-in 3.8636 Q207D None None XRAY 1.35 0.166 0.191 B 301.0 291.0 3 32 32 0 [[207, 497]] 1.0 5s84 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S89B Q04771 205 499 509.0 LU8:501 Type1 Inactive DFGin 6.984 13.3612 BLAminus -124.97, 163.75 76.76, 88.69 -102.06, 21.8 303.74, 177.29 -68.27, -19.19 in-out in 8.8655 Saltbr-out 4.7724 HRD-in -81.65, -52.32 78.48, -1.17 out-in-out SNCoio in-out ActLoopNT-in 2.9216 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.77, 165.98 APE9-dihe-na -60.57, 167.11 APE8-dihe-in -63.21, 128.67 APE8-rot-in 299.1 APE67-dihe-in -57.43, -30.6 -61.18, -42.41 APE12-dist-in 10.2763 APE11-dist-out 6.1981 APE10-dist-out 8.9916 APE9-dist-in 3.7099 Q207D None None XRAY 1.3 0.156 0.174 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s89 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6SRHA Q04771 201 499 509.0 LU8:501 Type1 Inactive DFGin 8.3373 13.4422 BLAminus -122.57, 162.03 75.26, 88.46 -99.42, 24.23 300.0, 175.86 -68.83, -17.25 in-out in 9.2713 Saltbr-out 6.1836 HRD-in -78.85, -52.97 79.59, -0.55 out-in-out SNCoio in-out ActLoopNT-in 2.9523 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.6, 171.91 APE9-dihe-na -65.69, 166.15 APE8-dihe-in -64.37, 126.3 APE8-rot-in 301.19 APE67-dihe-in -57.05, -29.89 -63.28, -37.95 APE12-dist-in 10.9956 APE11-dist-out 6.191 APE10-dist-out 8.8899 APE9-dist-in 3.6719 Q207D None None XRAY 1.25 0.134 0.16 A 301.0 288.0 11 32 21 11 [[207, 497]] 1.0 6srh TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7BB Q04771 205 499 509.0 LU8:501,XH7:506 Type1,Allosteric Inactive DFGin 7.0215 13.362 BLAminus -121.46, 161.83 78.44, 88.34 -102.47, 19.49 301.42, 173.88 -65.45, -20.59 in-out in 8.7895 Saltbr-out 4.6853 HRD-in -74.99, -55.16 78.67, -0.58 out-in-out SNCoio in-out ActLoopNT-in 2.9128 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.52, 156.89 APE9-dihe-na -51.95, 170.55 APE8-dihe-in -69.31, 128.28 APE8-rot-in 299.94 APE67-dihe-in -63.25, -25.99 -60.99, -39.27 APE12-dist-in 10.4037 APE11-dist-out 6.3927 APE10-dist-out 9.0949 APE9-dist-in 3.8072 Q207D None None XRAY 1.32 0.169 0.195 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7b TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7CB Q04771 205 499 509.0 LU8:501,T5Y:505 Type1,Allosteric Inactive DFGin 7.0621 13.3895 BLAminus -126.3, 161.98 79.71, 89.61 -103.06, 23.5 302.55, 173.63 -67.99, -21.1 in-out in 8.8544 Saltbr-out 4.7577 HRD-in -77.43, -53.45 76.82, -0.13 out-in-out SNCoio in-out ActLoopNT-in 2.9125 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.01, 166.06 APE9-dihe-na -60.91, 165.47 APE8-dihe-in -62.27, 130.39 APE8-rot-in 299.14 APE67-dihe-in -63.71, -26.19 -64.69, -37.05 APE12-dist-in 10.3644 APE11-dist-out 6.2378 APE10-dist-out 8.9937 APE9-dist-in 3.938 Q207D None None XRAY 1.31 0.161 0.179 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7c TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7DB Q04771 205 499 509.0 LU8:501,XHD:505 Type1,Allosteric Inactive DFGin 6.9999 13.3494 BLAminus -123.42, 163.32 74.65, 90.04 -104.07, 23.56 302.54, 177.54 -72.51, -12.63 in-out in 8.7588 Saltbr-out 4.7023 HRD-in -77.61, -53.61 80.79, -1.13 out-in-out SNCoio in-out ActLoopNT-in 2.9693 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.29, 164.81 APE9-dihe-na -57.91, 162.72 APE8-dihe-in -60.44, 129.2 APE8-rot-in 299.64 APE67-dihe-in -59.07, -29.49 -62.4, -40.3 APE12-dist-in 10.3581 APE11-dist-out 6.219 APE10-dist-out 9.0261 APE9-dist-in 3.7864 Q207D None None XRAY 1.31 0.165 0.185 B 301.0 295.0 0 32 32 0 [[207, 497]] 1.0 5s7d TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7EB Q04771 205 499 509.0 LU8:501,XEA:505 Type1,Allosteric Inactive DFGin 7.0009 13.4563 BLAminus -126.91, 163.64 73.07, 91.25 -103.42, 21.63 301.95, 174.37 -67.85, -18.9 in-out in 8.8128 Saltbr-out 4.7223 HRD-in -77.73, -53.3 79.65, -3.06 out-in-out SNCoio in-out ActLoopNT-in 2.929 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.66, 166.82 APE9-dihe-na -61.55, 164.95 APE8-dihe-in -59.98, 129.55 APE8-rot-in 299.19 APE67-dihe-in -58.01, -29.13 -63.05, -41.4 APE12-dist-in 10.2582 APE11-dist-out 6.2149 APE10-dist-out 9.0083 APE9-dist-in 3.801 Q207D None None XRAY 1.32 0.168 0.189 B 301.0 293.0 2 32 32 0 [[207, 497]] 1.0 5s7e TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7KB Q04771 205 499 509.0 LU8:501,XEJ:504 Type1,Allosteric Inactive DFGin 6.9806 13.2701 BLAminus -124.3, 164.86 75.9, 87.47 -102.78, 21.12 305.49, 0.35 -65.97, -18.91 in-out in 8.8339 Saltbr-out 4.6466 HRD-in -79.74, -53.13 79.6, -2.25 out-in-out SNCoio in-out ActLoopNT-in 2.8589 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.28, 163.22 APE9-dihe-na -60.14, 169.9 APE8-dihe-in -64.39, 127.18 APE8-rot-in 298.46 APE67-dihe-in -57.76, -29.28 -59.11, -42.6 APE12-dist-in 10.4215 APE11-dist-out 6.3009 APE10-dist-out 8.9738 APE9-dist-in 3.6767 None None None XRAY 1.31 0.162 0.188 B 301.0 293.0 2 32 32 0 [[207, 497]] 1.0 5s7k TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7MB Q04771 208 499 509.0 LU8:501,HVK:505 Type1,Allosteric Inactive DFGin 7.009 13.3206 BLAminus -124.89, 160.91 76.23, 87.23 -100.03, 22.28 300.52, 174.89 -68.18, -14.07 in-out in 8.451 Saltbr-out 4.2021 HRD-in -76.72, -54.96 80.02, -2.85 out-in-out SNCoio in-out ActLoopNT-in 2.9243 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.58, 168.17 APE9-dihe-na -62.95, 162.95 APE8-dihe-in -58.04, 127.45 APE8-rot-in 298.56 APE67-dihe-in -59.18, -25.23 -62.3, -40.69 APE12-dist-in 10.3695 APE11-dist-out 6.2098 APE10-dist-out 8.9384 APE9-dist-in 3.8142 Q207D None None XRAY 1.32 0.171 0.195 B 301.0 290.0 2 32 32 0 [[207, 497]] 1.0 5s7m TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7NB Q04771 207 499 509.0 LU8:501,2AI:505 Type1,Allosteric Inactive DFGin 7.0053 13.4202 BLAminus -126.13, 161.61 77.78, 88.49 -101.78, 20.71 303.39, 175.45 -67.06, -19.53 in-out in 8.8596 Saltbr-out 4.7161 HRD-in -78.53, -54.27 81.6, -6.08 out-in-out SNCoio in-out ActLoopNT-in 2.9573 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.2, 164.62 APE9-dihe-na -57.6, 161.75 APE8-dihe-in -58.85, 126.75 APE8-rot-in 300.18 APE67-dihe-in -61.19, -26.66 -59.93, -40.36 APE12-dist-in 10.2703 APE11-dist-out 6.1513 APE10-dist-out 9.0073 APE9-dist-in 3.7557 Q207D None None XRAY 1.3 0.163 0.186 B 301.0 290.0 3 32 32 0 [[207, 497]] 1.0 5s7n TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7SB Q04771 205 499 509.0 LU8:501,09V:505 Type1,Allosteric Inactive DFGin 6.9873 13.4064 BLAminus -127.22, 162.49 75.55, 89.77 -103.58, 21.52 302.17, 178.46 -71.16, -15.05 in-out in 8.8785 Saltbr-out 4.7655 HRD-in -78.6, -54.23 80.1, -1.5 out-in-out SNCoio in-out ActLoopNT-in 2.9249 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.31, 165.17 APE9-dihe-na -61.08, 163.96 APE8-dihe-in -59.96, 128.29 APE8-rot-in 298.36 APE67-dihe-in -59.32, -26.33 -61.06, -42.91 APE12-dist-in 10.2601 APE11-dist-out 6.1893 APE10-dist-out 9.0191 APE9-dist-in 3.7777 Q207D None None XRAY 1.3 0.153 0.171 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7s TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7VB Q04771 205 499 509.0 LU8:501,XH1:505 Type1,Allosteric Inactive DFGin 7.0144 13.5121 BLAminus -126.76, 162.04 76.91, 90.47 -102.68, 21.03 302.06, 175.32 -69.9, -15.12 in-out in 8.9289 Saltbr-out 4.7899 HRD-in -78.61, -53.05 79.7, -1.04 out-in-out SNCoio in-out ActLoopNT-in 2.9267 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.43, 165.76 APE9-dihe-na -60.04, 163.83 APE8-dihe-in -61.01, 129.39 APE8-rot-in 297.49 APE67-dihe-in -59.56, -27.34 -62.0, -41.39 APE12-dist-in 10.2933 APE11-dist-out 6.1833 APE10-dist-out 9.0048 APE9-dist-in 3.8521 Q207D None None XRAY 1.31 0.154 0.172 B 301.0 291.0 4 32 32 0 [[207, 497]] 1.0 5s7v TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7XB Q04771 205 499 509.0 LU8:501,LGA:505 Type1,Allosteric Inactive DFGin 7.0314 13.379 BLAminus -128.0, 163.2 78.06, 89.3 -102.46, 20.69 301.92, 175.18 -69.56, -15.46 in-out in 8.8274 Saltbr-out 4.6398 HRD-in -76.89, -56.14 80.13, -1.68 out-in-out SNCoio in-out ActLoopNT-in 2.9186 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.04, 166.03 APE9-dihe-na -61.79, 165.52 APE8-dihe-in -59.06, 127.18 APE8-rot-in 299.22 APE67-dihe-in -59.1, -28.73 -61.83, -40.56 APE12-dist-in 10.3779 APE11-dist-out 6.1653 APE10-dist-out 8.945 APE9-dist-in 3.807 Q207D None None XRAY 1.3 0.151 0.169 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7x TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7ZB Q04771 205 499 509.0 LU8:501,BYZ:505 Type1,Allosteric Inactive DFGin 6.9632 13.3741 BLAminus -125.8, 161.65 77.14, 88.32 -102.44, 23.35 302.89, 177.91 -73.03, -13.12 in-out in 8.7708 Saltbr-out 4.7211 HRD-in -76.79, -54.43 80.82, -3.64 out-in-out SNCoio in-out ActLoopNT-in 2.9201 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.61, 165.38 APE9-dihe-na -60.57, 163.68 APE8-dihe-in -58.84, 127.79 APE8-rot-in 300.37 APE67-dihe-in -58.11, -27.66 -62.19, -41.34 APE12-dist-in 10.3506 APE11-dist-out 6.1474 APE10-dist-out 9.0017 APE9-dist-in 3.8366 Q207D None None XRAY 1.3 0.163 0.184 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7z TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S82B Q04771 205 499 509.0 LU8:501,LAC:505 Type1,Allosteric Inactive DFGin 6.6555 13.3978 BLAminus -126.04, 165.16 75.17, 84.42 -92.96, 20.32 298.14, 1.79 -72.8, -17.41 in-out in 8.9053 Saltbr-out 4.4972 HRD-in -74.85, -51.79 76.63, 2.28 out-in-in SNCoii in-in ActLoopNT-in 2.8295 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.55, 160.28 APE9-dihe-na 116.12, -172.15 APE8-dihe-in -92.31, 127.42 APE8-rot-in 312.53 APE67-dihe-in -58.12, -32.21 -55.48, -45.17 APE12-dist-in 11.3772 APE11-dist-in 12.1036 APE10-dist-in 6.2531 APE9-dist-in 3.7924 Q207D None None XRAY 1.71 0.211 0.253 B 301.0 284.0 11 32 25 7 [[207, 497]] 1.0 5s82 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S86B Q04771 205 499 509.0 LU8:501,XK7:505 Type1,Allosteric Inactive DFGin 6.9997 13.343 BLAminus -124.78, 165.07 76.1, 88.35 -101.51, 22.18 301.71, 177.78 -69.78, -18.41 in-out in 8.8877 Saltbr-out 4.7455 HRD-in -81.45, -50.76 76.49, -0.86 out-in-in SNCoii in-in ActLoopNT-in 2.9308 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.0, 158.9 APE9-dihe-na 111.5, 158.23 APE8-dihe-in -70.2, 127.65 APE8-rot-in 298.18 APE67-dihe-in -59.26, -28.16 -59.39, -41.48 APE12-dist-in 11.6278 APE11-dist-in 12.2182 APE10-dist-in 6.6711 APE9-dist-in 3.6866 Q207D None None XRAY 1.31 0.169 0.19 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s86 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S87B Q04771 205 499 509.0 LU8:501,XKD:505 Type1,Allosteric Inactive DFGin 6.9646 13.3873 BLAminus -125.7, 164.87 74.71, 88.13 -101.5, 22.91 303.75, 177.62 -68.86, -17.71 in-out in 8.8328 Saltbr-out 4.7493 HRD-in -82.36, -52.31 79.91, -1.72 out-in-out SNCoio in-out ActLoopNT-in 2.92 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.25, 165.32 APE9-dihe-na -62.4, 164.8 APE8-dihe-in -61.06, 127.57 APE8-rot-in 297.97 APE67-dihe-in -58.73, -29.86 -59.37, -42.06 APE12-dist-in 10.2433 APE11-dist-out 6.1731 APE10-dist-out 8.9694 APE9-dist-in 3.6795 Q207D None None XRAY 1.3 0.161 0.181 B 301.0 290.0 5 32 32 0 [[207, 497]] 1.0 5s87 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S88B Q04771 205 499 509.0 LU8:501,XKS:505 Type1,Allosteric Inactive DFGin 6.9732 13.376 BLAminus -122.04, 163.88 74.1, 88.2 -100.76, 18.77 302.29, 178.38 -66.87, -16.44 in-out in 8.8711 Saltbr-out 4.7216 HRD-in -80.9, -52.59 78.53, -3.8 out-in-out SNCoio in-out ActLoopNT-in 2.94 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.43, 164.81 APE9-dihe-na -62.32, 166.78 APE8-dihe-in -60.75, 128.44 APE8-rot-in 298.57 APE67-dihe-in -57.52, -28.98 -62.58, -40.65 APE12-dist-in 10.3296 APE11-dist-out 6.1488 APE10-dist-out 9.0268 APE9-dist-in 3.7076 Q207D None None XRAY 1.31 0.16 0.179 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s88 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S8AB Q04771 205 499 509.0 LU8:501,XKY:505 Type1,Allosteric Inactive DFGin 6.9551 13.3366 BLAminus -125.42, 163.04 76.47, 86.69 -100.25, 21.43 305.15, 178.88 -67.55, -16.71 in-out in 8.827 Saltbr-out 4.6784 HRD-in -78.68, -54.41 80.9, -2.81 out-in-out SNCoio in-out ActLoopNT-in 2.9379 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.78, 163.73 APE9-dihe-na -58.28, 164.12 APE8-dihe-in -61.01, 126.61 APE8-rot-in 297.82 APE67-dihe-in -58.41, -30.66 -59.54, -41.22 APE12-dist-in 10.2403 APE11-dist-out 6.1169 APE10-dist-out 9.04 APE9-dist-in 3.7761 Q207D None None XRAY 1.3 0.158 0.179 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s8a TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S75B Q04771 205 499 509.0 LU8:501,HUH:505,HUH:506 Type1,Allosteric,Allosteric Inactive DFGin 7.0427 13.384 BLAminus -125.56, 161.73 76.89, 90.9 -104.0, 22.37 302.45, 178.35 -68.36, -16.58 in-out in 8.8028 Saltbr-out 4.754 HRD-in -77.19, -54.35 79.9, -2.77 out-in-out SNCoio in-out ActLoopNT-in 2.9254 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.92, 165.96 APE9-dihe-na -62.98, 165.92 APE8-dihe-in -61.22, 127.2 APE8-rot-in 298.98 APE67-dihe-in -59.47, -28.54 -61.97, -40.32 APE12-dist-in 10.3728 APE11-dist-out 6.1931 APE10-dist-out 8.992 APE9-dist-in 3.7784 Q207D None None XRAY 1.3 0.156 0.173 B 301.0 293.0 2 32 32 0 [[207, 497]] 1.0 5s75 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S79A Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.3593 13.3075 BLAminus -117.94, 162.46 74.88, 92.31 -102.33, 24.3 297.49, 0.79 -68.18, -20.94 in-out in 9.0932 Saltbr-out 5.8521 HRD-in -74.67, -52.38 75.13, 0.8 out-in-out SNCoio in-out ActLoopNT-in 2.9226 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -130.7, 172.52 APE9-dihe-na -62.7, 161.48 APE8-dihe-in -63.27, 127.15 APE8-rot-in 306.54 APE67-dihe-in -57.17, -31.15 -61.23, -39.7 APE12-dist-none 999.0 APE11-dist-out 6.3758 APE10-dist-out 8.7554 APE9-dist-in 3.742 Q207D None None XRAY 1.5 0.18 0.206 A 301.0 284.0 14 32 20 12 [[207, 497]] 1.0 5s79 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7AB Q04771 205 499 509.0 LU8:501,T5V:505,T5V:506 Type1,Allosteric,Allosteric Inactive DFGin 7.0387 13.38 BLAminus -126.41, 163.07 76.94, 87.35 -100.8, 22.69 302.52, 175.53 -70.21, -15.13 in-out in 8.793 Saltbr-out 4.7212 HRD-in -77.59, -56.91 81.94, -2.79 out-in-out SNCoio in-out ActLoopNT-in 2.9306 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.27, 167.32 APE9-dihe-na -61.57, 164.52 APE8-dihe-in -61.32, 127.79 APE8-rot-in 299.15 APE67-dihe-in -59.77, -26.87 -62.23, -39.78 APE12-dist-in 10.3297 APE11-dist-out 6.2327 APE10-dist-out 8.9798 APE9-dist-in 3.8335 Q207D None None XRAY 1.3 0.16 0.18 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7a TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7EA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509 Type1,Allosteric,Allosteric Inactive DFGin 8.3788 13.303 BLAminus -121.44, 162.36 74.46, 91.44 -103.29, 27.05 299.26, 176.52 -69.12, -17.65 in-out in 9.1784 Saltbr-out 6.1061 HRD-in -79.8, -52.73 76.32, 0.43 out-in-out SNCoio in-out ActLoopNT-in 2.8856 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.76, 172.59 APE9-dihe-na -57.54, 160.03 APE8-dihe-in -61.32, 126.08 APE8-rot-in 304.6 APE67-dihe-in -53.51, -32.05 -63.31, -40.67 APE12-dist-none 999.0 APE11-dist-out 6.3076 APE10-dist-out 8.8411 APE9-dist-in 3.7139 Q207D None None XRAY 1.32 0.168 0.189 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s7e TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7FA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509 Type1,Allosteric,Allosteric Inactive DFGin 8.3693 13.3205 BLAminus -122.11, 160.49 78.65, 89.18 -101.96, 26.72 301.12, 175.97 -69.09, -20.41 in-out in 9.1008 Saltbr-out 6.107 HRD-in -78.16, -52.77 77.11, -0.2 out-in-out SNCoio in-out ActLoopNT-in 2.9175 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.41, 172.12 APE9-dihe-na -64.48, 163.27 APE8-dihe-in -60.82, 122.78 APE8-rot-in 304.26 APE67-dihe-in -57.8, -32.72 -63.43, -34.75 APE12-dist-none 999.0 APE11-dist-out 6.2328 APE10-dist-out 8.8508 APE9-dist-in 3.6754 Q207D None None XRAY 1.31 0.151 0.169 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s7f TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7FB Q04771 205 499 509.0 LU8:501,XH4:505,XH4:506 Type1,Allosteric,Allosteric Inactive DFGin 7.0038 13.3859 BLAminus -125.15, 160.98 75.58, 90.9 -103.26, 20.62 302.27, 174.02 -66.35, -18.49 in-out in 8.851 Saltbr-out 4.7675 HRD-in -78.67, -52.91 79.11, -3.95 out-in-out SNCoio in-out ActLoopNT-in 2.9186 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.71, 164.43 APE9-dihe-na -63.66, 165.2 APE8-dihe-in -60.32, 128.18 APE8-rot-in 298.19 APE67-dihe-in -60.19, -25.76 -61.92, -39.78 APE12-dist-in 10.3447 APE11-dist-out 6.1141 APE10-dist-out 9.0418 APE9-dist-in 3.8278 Q207D None None XRAY 1.31 0.151 0.169 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7f TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7GA Q04771 202 498 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.4994 13.3287 BLAminus -125.16, 165.77 74.59, 86.92 -99.45, 20.56 296.92, 176.9 -55.21, -25.24 in-out in 9.3288 Saltbr-out 5.7883 HRD-in -78.53, -53.51 74.34, 2.0 out-in-none SNCoin in-none ActLoopNT-in 2.9022 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -116.42, 161.19 APE9-dihe-na 107.2, -168.38 APE8-dihe-in -91.58, 123.63 APE8-rot-in 309.25 APE67-dihe-in -59.99, -30.06 -55.11, -41.51 APE12-dist-none 999.0 APE11-dist-in 10.3661 APE10-dist-in 6.4234 APE9-dist-in 3.9062 Q207D None None XRAY 1.78 0.206 0.252 A 301.0 284.0 13 32 19 13 [[207, 497]] 1.0 5s7g TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7OA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.2912 13.4214 BLAminus -118.75, 163.36 74.89, 87.72 -99.53, 25.84 300.09, 2.07 -68.13, -17.89 in-out in 9.2067 Saltbr-out 6.1972 HRD-in -76.07, -55.9 78.85, -1.81 out-in-out SNCoio in-out ActLoopNT-in 2.9138 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.0, 170.72 APE9-dihe-na -63.29, 163.84 APE8-dihe-in -60.21, 123.9 APE8-rot-in 304.44 APE67-dihe-in -59.71, -29.26 -62.37, -36.73 APE12-dist-in 11.0381 APE11-dist-out 6.0384 APE10-dist-out 8.8683 APE9-dist-in 3.6435 Q207D None None XRAY 1.43 0.165 0.189 A 301.0 287.0 12 32 21 11 [[207, 497]] 1.0 5s7o TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7QA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.3905 13.1124 BLAminus -122.32, 165.01 69.61, 90.09 -98.74, 20.54 300.47, 4.84 -55.87, -28.73 in-out in 9.1154 Saltbr-out 6.1758 HRD-in -80.49, -54.34 80.36, -1.4 out-in-out SNCoio in-out ActLoopNT-in 2.9335 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.26, 178.66 APE9-dihe-na -63.48, 166.31 APE8-dihe-in -61.68, 126.19 APE8-rot-in 310.31 APE67-dihe-in -52.14, -34.66 -61.41, -42.72 APE12-dist-none 999.0 APE11-dist-out 6.7892 APE10-dist-out 8.8904 APE9-dist-in 3.5385 Q207D None None XRAY 1.53 0.209 0.243 A 301.0 282.0 16 32 19 13 [[207, 497]] 1.0 5s7q TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7UA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.3051 13.2129 BLAminus -114.05, 162.83 73.86, 86.44 -96.11, 24.11 301.91, 5.0 -63.32, -18.47 in-out in 9.2232 Saltbr-out 5.6693 HRD-in -78.6, -56.95 81.06, 1.88 out-in-none SNCoin in-none ActLoopNT-in 2.8879 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -102.37, -33.42 APE9-dihe-na -82.13, -169.33 APE8-dihe-in -70.61, 128.02 APE8-rot-in 308.81 APE67-dihe-in -53.65, -30.76 -61.02, -43.28 APE12-dist-none 999.0 APE11-dist-in 10.9037 APE10-dist-in 6.4566 APE9-dist-in 3.6543 Q207D None None XRAY 1.59 0.219 0.261 A 301.0 280.0 18 32 19 13 [[207, 497]] 1.0 5s7u TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7UB Q04771 205 499 509.0 LU8:501,XGY:505,XGY:506 Type1,Allosteric,Allosteric Inactive DFGin 6.6967 13.3542 BLAminus -130.21, 164.61 74.6, 82.7 -94.38, 13.73 305.4, 176.35 -55.24, -22.33 in-out in 8.956 Saltbr-out 4.6866 HRD-in -75.48, -53.06 77.34, -3.38 out-in-out SNCoio in-out ActLoopNT-in 2.8147 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -164.99, 129.38 APE9-dihe-na -126.69, -126.94 APE8-dihe-in -91.63, 124.43 APE8-rot-in 299.73 APE67-dihe-in -58.25, -31.07 -56.39, -48.22 APE12-dist-in 10.8295 APE11-dist-in 11.4695 APE10-dist-out 9.5141 APE9-dist-in 4.0299 Q207D None None XRAY 1.59 0.219 0.261 B 301.0 279.0 16 32 23 9 [[207, 497]] 1.0 5s7u TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7VA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.3286 13.327 BLAminus -124.73, 163.23 77.04, 90.62 -101.21, 26.19 302.83, 177.61 -67.83, -17.56 in-out in 9.1318 Saltbr-out 5.9192 HRD-in -78.43, -52.77 77.91, -0.2 out-in-out SNCoio in-out ActLoopNT-in 2.9305 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.42, 168.77 APE9-dihe-na -60.41, 164.86 APE8-dihe-in -63.38, 124.43 APE8-rot-in 302.99 APE67-dihe-in -57.33, -32.29 -63.57, -36.66 APE12-dist-none 999.0 APE11-dist-out 6.1362 APE10-dist-out 8.8767 APE9-dist-in 3.6862 Q207D None None XRAY 1.31 0.154 0.172 A 301.0 282.0 16 32 20 12 [[207, 497]] 1.0 5s7v TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7WA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.3816 13.4221 BLAminus -120.63, 163.92 74.5, 89.95 -100.48, 28.03 301.03, 179.86 -70.31, -18.41 in-out in 9.2435 Saltbr-out 6.2008 HRD-in -78.77, -52.99 79.89, -3.2 out-in-out SNCoio in-out ActLoopNT-in 2.9396 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.35, 170.12 APE9-dihe-na -61.34, 168.74 APE8-dihe-in -65.88, 124.22 APE8-rot-in 304.99 APE67-dihe-in -56.25, -29.94 -63.21, -38.79 APE12-dist-none 999.0 APE11-dist-out 6.2527 APE10-dist-out 8.9271 APE9-dist-in 3.6958 Q207D None None XRAY 1.33 0.164 0.186 A 301.0 284.0 14 32 19 13 [[207, 497]] 1.0 5s7w TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7YA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.3776 13.3431 BLAminus -121.01, 162.15 74.22, 90.85 -101.18, 24.99 303.51, 176.94 -65.0, -19.5 in-out in 9.2462 Saltbr-out 6.2055 HRD-in -79.92, -53.25 77.89, -1.46 out-in-out SNCoio in-out ActLoopNT-in 2.9029 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -125.05, 171.62 APE9-dihe-na -63.16, 165.02 APE8-dihe-in -61.65, 124.26 APE8-rot-in 302.58 APE67-dihe-in -56.65, -33.92 -63.4, -36.98 APE12-dist-none 999.0 APE11-dist-out 6.068 APE10-dist-out 8.8721 APE9-dist-in 3.6119 Q207D None None XRAY 1.37 0.161 0.184 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s7y TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S80A Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509 Type1,Allosteric,Allosteric Inactive DFGin 8.3137 13.3058 BLAminus -112.55, 159.81 78.34, 88.26 -99.06, 22.42 300.25, 0.46 -63.75, -19.98 in-out in 9.0251 Saltbr-out 5.8825 HRD-in -76.34, -54.31 74.73, 2.06 out-in-out SNCoio in-out ActLoopNT-in 2.9057 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -128.9, 168.55 APE9-dihe-na -54.89, 157.92 APE8-dihe-in -57.52, 122.86 APE8-rot-in 308.47 APE67-dihe-in -52.78, -30.68 -62.36, -41.16 APE12-dist-none 999.0 APE11-dist-out 6.1425 APE10-dist-out 8.7825 APE9-dist-in 3.7345 Q207D None None XRAY 1.67 0.197 0.231 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s80 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S80B Q04771 205 499 509.0 LU8:501,XGM:505,XGM:506 Type1,Allosteric,Allosteric Inactive DFGin 7.0267 13.5533 BLAminus -130.83, 163.29 75.8, 86.12 -98.93, 18.93 301.48, 172.59 -65.51, -18.83 in-out in 8.9692 Saltbr-out 4.718 HRD-in -78.19, -55.2 81.16, -3.45 out-in-out SNCoio in-out ActLoopNT-in 2.8547 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.24, 160.71 APE9-dihe-na -59.43, 165.2 APE8-dihe-in -58.98, 127.47 APE8-rot-in 308.35 APE67-dihe-in -58.04, -28.7 -56.74, -44.6 APE12-dist-in 10.4101 APE11-dist-out 6.1264 APE10-dist-out 9.0862 APE9-dist-in 3.8114 Q207D None None XRAY 1.67 0.197 0.231 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s80 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S82A Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.468 13.2543 BLAminus -122.58, 165.4 75.09, 85.58 -98.64, 22.96 294.39, 0.35 -56.95, -25.74 in-out in 9.3363 Saltbr-out 5.524 HRD-in -76.5, -58.03 77.63, 6.82 out-in-none SNCoin in-none ActLoopNT-in 2.8593 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -106.37, 156.71 APE9-dihe-na 110.11, -167.89 APE8-dihe-in -91.26, 123.24 APE8-rot-in 309.79 APE67-dihe-in -54.4, -31.68 -54.65, -45.23 APE12-dist-none 999.0 APE11-dist-in 10.8938 APE10-dist-in 6.4362 APE9-dist-in 3.9819 Q207D None None XRAY 1.71 0.211 0.253 A 301.0 279.0 19 32 19 13 [[207, 497]] 1.0 5s82 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S87A Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.356 13.334 BLAminus -124.64, 162.22 77.24, 89.92 -101.8, 26.16 301.34, 177.73 -70.64, -14.84 in-out in 9.288 Saltbr-out 6.0745 HRD-in -77.97, -54.71 79.68, 0.35 out-in-out SNCoio in-out ActLoopNT-in 2.9318 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.28, 171.55 APE9-dihe-na -60.97, 165.72 APE8-dihe-in -65.13, 123.33 APE8-rot-in 301.16 APE67-dihe-in -56.7, -32.97 -59.78, -39.02 APE12-dist-none 999.0 APE11-dist-out 6.2457 APE10-dist-out 9.0747 APE9-dist-in 3.5643 Q207D None None XRAY 1.3 0.161 0.181 A 301.0 284.0 15 32 19 13 [[207, 497]] 1.0 5s87 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S88A Q04771 202 499 509.0 LU8:501,LU8:506,LU8:507 Type1,Allosteric,Allosteric Inactive DFGin 8.3908 13.328 BLAminus -125.32, 162.15 75.36, 89.99 -102.31, 27.55 301.87, 179.45 -66.0, -20.71 in-out in 9.2871 Saltbr-out 6.0568 HRD-in -78.45, -54.06 78.95, -0.59 out-in-out SNCoio in-out ActLoopNT-in 2.9384 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.53, 173.56 APE9-dihe-na -66.93, 166.27 APE8-dihe-in -60.51, 123.12 APE8-rot-in 301.13 APE67-dihe-in -58.29, -28.73 -59.87, -40.21 APE12-dist-none 999.0 APE11-dist-out 6.1893 APE10-dist-out 8.9793 APE9-dist-in 3.5981 Q207D None None XRAY 1.31 0.16 0.179 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s88 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S9KA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.3518 13.3497 BLAminus -119.09, 162.43 73.95, 91.92 -101.37, 24.48 300.38, 179.39 -71.09, -13.1 in-out in 9.3128 Saltbr-out 6.1587 HRD-in -79.72, -52.91 78.84, -1.65 out-in-out SNCoio in-out ActLoopNT-in 2.9269 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.92, 173.99 APE9-dihe-na -63.97, 163.84 APE8-dihe-in -62.03, 121.91 APE8-rot-in 301.87 APE67-dihe-in -54.23, -35.11 -55.21, -43.69 APE12-dist-none 999.0 APE11-dist-out 6.3795 APE10-dist-out 9.1471 APE9-dist-in 3.5222 Q207D None None XRAY 1.35 0.176 0.2 A 301.0 281.0 18 32 19 13 [[207, 497]] 1.0 5s9k TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6SRHB Q04771 205 499 509.0 LU8:501,LU8:502,LU8:503 Type1,Allosteric,Allosteric Inactive DFGin 6.9365 13.3915 BLAminus -126.84, 164.05 75.03, 87.93 -100.83, 18.93 301.99, 177.59 -71.89, -11.94 in-out in 8.9116 Saltbr-out 4.7467 HRD-in -80.94, -52.46 80.13, -0.8 out-in-out SNCoio in-out ActLoopNT-in 2.9248 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.66, 165.78 APE9-dihe-na -63.94, 166.94 APE8-dihe-in -62.11, 128.55 APE8-rot-in 298.15 APE67-dihe-in -60.05, -27.13 -57.77, -43.71 APE12-dist-in 10.3292 APE11-dist-out 6.1224 APE10-dist-out 9.0702 APE9-dist-in 3.8077 Q207D None None XRAY 1.25 0.134 0.16 B 301.0 295.0 0 32 32 0 [[207, 497]] 1.0 6srh TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S77A Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,BAQ:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3912 13.2913 BLAminus -123.97, 162.56 76.16, 90.86 -104.32, 25.92 302.2, 176.49 -70.33, -17.0 in-out in 9.1926 Saltbr-out 6.1664 HRD-in -75.36, -54.06 76.91, 1.59 out-in-out SNCoio in-out ActLoopNT-in 2.9281 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.85, 171.29 APE9-dihe-na -63.22, 166.14 APE8-dihe-in -65.07, 121.84 APE8-rot-in 300.34 APE67-dihe-in -56.11, -31.98 -61.83, -38.01 APE12-dist-none 999.0 APE11-dist-out 6.3001 APE10-dist-out 8.8524 APE9-dist-in 3.638 Q207D None None XRAY 1.31 0.166 0.185 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s77 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7DA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,XHD:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.386 13.3906 BLAminus -121.08, 159.87 78.87, 90.19 -102.41, 28.04 302.41, 178.35 -70.75, -16.32 in-out in 9.2242 Saltbr-out 6.1349 HRD-in -78.63, -52.52 79.29, -0.45 out-in-out SNCoio in-out ActLoopNT-in 2.9565 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -121.09, 171.05 APE9-dihe-na -61.33, 164.08 APE8-dihe-in -64.43, 124.8 APE8-rot-in 301.32 APE67-dihe-in -57.7, -30.13 -64.02, -36.73 APE12-dist-none 999.0 APE11-dist-out 6.2255 APE10-dist-out 8.8952 APE9-dist-in 3.7101 Q207D None None XRAY 1.31 0.165 0.185 A 301.0 284.0 14 32 20 12 [[207, 497]] 1.0 5s7d TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7JA Q04771 201 499 509.0 LU8:501,LU8:506,LU8:507,XHG:508 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3538 13.4667 BLAminus -120.47, 161.42 75.57, 90.44 -100.52, 24.64 297.99, 178.42 -66.79, -16.07 in-out in 9.1183 Saltbr-out 6.1093 HRD-in -76.74, -56.59 80.01, 1.36 out-in-out SNCoio in-out ActLoopNT-in 2.8973 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.11, 169.97 APE9-dihe-na -61.08, 166.56 APE8-dihe-in -64.82, 124.61 APE8-rot-in 302.51 APE67-dihe-in -56.89, -31.73 -63.18, -39.12 APE12-dist-in 10.4402 APE11-dist-out 6.0435 APE10-dist-out 8.8554 APE9-dist-in 3.7007 Q207D None None XRAY 1.31 0.159 0.181 A 301.0 286.0 13 32 21 11 [[207, 497]] 1.0 5s7j TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7KA Q04771 202 499 509.0 LU8:501,LU8:506,LU8:507,XEJ:508 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3571 13.2978 BLAminus -121.51, 161.1 74.44, 89.19 -99.73, 25.08 301.6, 0.3 -69.43, -16.12 in-out in 9.3172 Saltbr-out 6.0158 HRD-in -77.56, -55.15 80.71, -0.51 out-in-none SNCoin in-none ActLoopNT-in 2.9289 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -93.42, -15.71 APE9-dihe-na -77.62, 169.4 APE8-dihe-in -59.03, 123.75 APE8-rot-in 304.14 APE67-dihe-in -58.63, -30.05 -60.7, -39.73 APE12-dist-none 999.0 APE11-dist-in 11.7963 APE10-dist-in 6.0089 APE9-dist-in 3.542 None None None XRAY 1.31 0.162 0.188 A 301.0 285.0 13 32 21 11 [[207, 497]] 1.0 5s7k TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7LA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,XHJ:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3207 13.3339 BLAminus -121.54, 163.42 75.33, 89.93 -101.4, 25.91 299.12, 0.16 -70.86, -16.31 in-out in 9.0177 Saltbr-out 5.8431 HRD-in -77.38, -52.76 78.01, -1.55 out-in-out SNCoio in-out ActLoopNT-in 2.8952 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -125.9, 174.3 APE9-dihe-na -64.5, 161.75 APE8-dihe-in -61.28, 122.78 APE8-rot-in 301.43 APE67-dihe-in -55.46, -32.76 -59.71, -41.51 APE12-dist-in 10.728 APE11-dist-out 6.281 APE10-dist-out 8.7835 APE9-dist-in 3.7348 Q207D None None XRAY 1.36 0.167 0.188 A 301.0 286.0 13 32 21 11 [[207, 497]] 1.0 5s7l TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7MA Q04771 202 499 509.0 LU8:501,LU8:507,HVK:508,HVK:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.2948 13.3693 BLAminus -125.86, 158.69 77.31, 90.22 -102.58, 22.57 301.89, 179.15 -62.4, -27.33 in-out in 9.2746 Saltbr-out 6.0388 HRD-in -76.09, -53.81 76.66, 2.88 out-in-out SNCoio in-out ActLoopNT-in 2.9008 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -128.0, 172.86 APE9-dihe-na -61.78, 157.6 APE8-dihe-in -61.33, 123.11 APE8-rot-in 304.71 APE67-dihe-in -54.75, -34.14 -63.89, -37.36 APE12-dist-in 11.0098 APE11-dist-out 6.3161 APE10-dist-out 8.7728 APE9-dist-in 3.828 Q207D None None XRAY 1.32 0.171 0.195 A 301.0 285.0 13 32 22 10 [[207, 497]] 1.0 5s7m TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7NA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,2AI:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3692 13.3273 BLAminus -120.76, 160.23 77.83, 89.81 -101.82, 25.77 300.77, 176.65 -67.07, -19.31 in-out in 9.1914 Saltbr-out 6.1991 HRD-in -78.31, -53.54 78.72, -0.87 out-in-out SNCoio in-out ActLoopNT-in 2.9272 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -111.12, 164.18 APE9-dihe-na -67.39, 173.07 APE8-dihe-in -61.91, 122.38 APE8-rot-in 303.15 APE67-dihe-in -57.78, -31.63 -60.2, -38.53 APE12-dist-none 999.0 APE11-dist-out 7.8661 APE10-dist-out 9.1731 APE9-dist-in 3.6452 Q207D None None XRAY 1.3 0.163 0.186 A 301.0 286.0 13 32 19 13 [[207, 497]] 1.0 5s7n TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7PA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,V1L:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3631 13.3516 BLAminus -121.35, 161.97 76.5, 90.18 -103.45, 27.08 300.94, 178.65 -69.09, -20.15 in-out in 9.1735 Saltbr-out 6.1815 HRD-in -76.2, -55.65 77.56, 1.63 out-in-out SNCoio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.42, 170.99 APE9-dihe-na -65.1, 166.64 APE8-dihe-in -64.52, 122.28 APE8-rot-in 301.0 APE67-dihe-in -57.28, -33.44 -60.97, -37.49 APE12-dist-none 999.0 APE11-dist-out 6.3362 APE10-dist-out 8.8101 APE9-dist-in 3.6483 Q207D None None XRAY 1.31 0.158 0.176 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s7p TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7SA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,09V:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3742 13.2602 BLAminus -125.11, 163.99 74.48, 91.32 -103.07, 26.34 302.08, 178.93 -70.93, -18.68 in-out in 9.1341 Saltbr-out 5.9366 HRD-in -77.09, -53.7 75.14, 2.55 out-in-out SNCoio in-out ActLoopNT-in 2.9167 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.89, 171.8 APE9-dihe-na -59.35, 163.03 APE8-dihe-in -63.02, 122.62 APE8-rot-in 301.85 APE67-dihe-in -55.53, -31.77 -61.45, -39.86 APE12-dist-in 10.5844 APE11-dist-out 6.3931 APE10-dist-out 8.796 APE9-dist-in 3.663 Q207D None None XRAY 1.3 0.153 0.171 A 301.0 287.0 11 32 23 9 [[207, 497]] 1.0 5s7s TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7TB Q04771 205 498 509.0 LU8:501,XGJ:505,XGJ:506,XGJ:507 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 7.3485 13.3837 BLAminus -130.84, 165.78 74.23, 86.23 -101.88, 22.54 301.68, 171.79 -65.62, -21.79 in-out in 8.8425 Saltbr-out 4.3703 HRD-in -75.87, -54.78 79.04, -1.82 out-in-out SNCoio in-out ActLoopNT-in 2.9373 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -106.86, 165.74 APE9-dihe-na -60.63, 163.96 APE8-dihe-in -61.22, 126.89 APE8-rot-in 299.34 APE67-dihe-in -62.98, -26.85 -63.53, -36.43 APE12-dist-in 10.5242 APE11-dist-out 6.9677 APE10-dist-out 9.1121 APE9-dist-in 3.8863 Q207D None None XRAY 1.3 0.155 0.174 B 301.0 294.0 0 32 32 0 [[207, 497]] 1.0 5s7t TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7XA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,LGA:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.365 13.3392 BLAminus -120.33, 161.6 75.96, 90.47 -101.36, 24.64 300.81, 178.23 -69.2, -15.97 in-out in 9.1534 Saltbr-out 6.1306 HRD-in -77.36, -53.88 76.8, 3.92 out-in-out SNCoio in-out ActLoopNT-in 2.9429 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.06, 170.39 APE9-dihe-na -62.49, 167.4 APE8-dihe-in -64.84, 124.15 APE8-rot-in 301.78 APE67-dihe-in -56.96, -32.72 -62.72, -36.99 APE12-dist-none 999.0 APE11-dist-out 6.2275 APE10-dist-out 8.8288 APE9-dist-in 3.6624 Q207D None None XRAY 1.3 0.151 0.169 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s7x TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S86A Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,XK7:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3538 13.3046 BLAminus -123.41, 163.19 74.35, 90.8 -102.12, 25.57 300.77, 178.94 -68.55, -18.48 in-out in 9.3264 Saltbr-out 6.0597 HRD-in -80.27, -53.89 78.04, 1.57 out-in-out SNCoio in-out ActLoopNT-in 2.9287 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.39, 173.24 APE9-dihe-na -67.68, 166.72 APE8-dihe-in -62.8, 124.74 APE8-rot-in 300.74 APE67-dihe-in -57.85, -29.86 -60.17, -41.27 APE12-dist-none 999.0 APE11-dist-out 6.4584 APE10-dist-out 9.1419 APE9-dist-in 3.5121 Q207D None None XRAY 1.31 0.169 0.19 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s86 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S89A Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,XKV:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3474 13.3769 BLAminus -121.17, 161.16 76.55, 91.35 -102.29, 27.94 301.32, 178.72 -70.17, -17.75 in-out in 9.3272 Saltbr-out 6.1807 HRD-in -77.92, -53.6 79.17, 0.85 out-in-out SNCoio in-out ActLoopNT-in 2.9289 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -120.5, 170.79 APE9-dihe-na -62.09, 168.52 APE8-dihe-in -64.51, 125.09 APE8-rot-in 300.94 APE67-dihe-in -58.18, -30.47 -62.43, -38.68 APE12-dist-none 999.0 APE11-dist-out 6.222 APE10-dist-out 9.1355 APE9-dist-in 3.6114 Q207D None None XRAY 1.3 0.156 0.174 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s89 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S8AA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,XKY:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3751 13.2912 BLAminus -123.48, 162.27 75.26, 91.11 -103.25, 28.11 302.42, 0.24 -70.28, -18.37 in-out in 9.2906 Saltbr-out 6.0868 HRD-in -77.3, -55.71 79.01, -0.21 out-in-out SNCoio in-out ActLoopNT-in 2.9308 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.8, 171.85 APE9-dihe-na -62.19, 164.47 APE8-dihe-in -62.15, 125.78 APE8-rot-in 303.5 APE67-dihe-in -57.64, -30.13 -63.86, -37.62 APE12-dist-none 999.0 APE11-dist-out 6.2268 APE10-dist-out 8.8929 APE9-dist-in 3.6826 Q207D None None XRAY 1.3 0.158 0.179 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s8a TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S8BB Q04771 205 499 509.0 LU8:501,XFV:505,XFV:506,XFV:507 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 6.8865 13.2682 BLAminus -123.76, 160.92 77.33, 89.17 -99.67, 18.5 303.55, 1.64 -66.62, -18.66 in-out in 8.6237 Saltbr-out 4.5819 HRD-in -80.97, -53.82 77.81, 1.71 out-in-out SNCoio in-out ActLoopNT-in 2.8434 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.23, 169.28 APE9-dihe-na -63.35, 164.6 APE8-dihe-in -57.58, 127.02 APE8-rot-in 306.31 APE67-dihe-in -56.16, -27.82 -54.33, -48.01 APE12-dist-in 10.2869 APE11-dist-out 6.129 APE10-dist-out 8.9433 APE9-dist-in 3.7756 Q207D None None XRAY 1.64 0.2 0.233 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s8b TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S75A Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,HUH:510,HUH:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.4122 13.3109 BLAminus -121.86, 161.2 77.57, 90.63 -103.17, 26.39 302.13, 178.97 -70.27, -17.43 in-out in 9.1959 Saltbr-out 6.1065 HRD-in -77.34, -53.49 77.65, 2.76 out-in-out SNCoio in-out ActLoopNT-in 2.9431 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.16, 170.77 APE9-dihe-na -65.21, 166.76 APE8-dihe-in -64.6, 123.77 APE8-rot-in 302.54 APE67-dihe-in -59.09, -30.5 -61.28, -37.14 APE12-dist-none 999.0 APE11-dist-out 6.2204 APE10-dist-out 8.9132 APE9-dist-in 3.6893 Q207D None None XRAY 1.3 0.156 0.173 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s75 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7AA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,T5V:509,T5V:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.342 13.3138 BLAminus -121.52, 160.72 75.85, 90.49 -101.87, 26.96 302.71, 179.1 -70.78, -16.97 in-out in 9.1949 Saltbr-out 6.1794 HRD-in -77.37, -53.71 77.98, -0.37 out-in-out SNCoio in-out ActLoopNT-in 2.9196 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -125.86, 170.85 APE9-dihe-na -58.96, 161.85 APE8-dihe-in -63.33, 122.4 APE8-rot-in 301.84 APE67-dihe-in -56.7, -33.07 -63.45, -35.84 APE12-dist-none 999.0 APE11-dist-out 6.3662 APE10-dist-out 8.8519 APE9-dist-in 3.6683 Q207D None None XRAY 1.3 0.16 0.18 A 301.0 285.0 14 32 20 12 [[207, 497]] 1.0 5s7a TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7BA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,XH7:509,XH7:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.4061 13.3525 BLAminus -122.54, 161.25 77.75, 89.14 -102.53, 25.49 298.26, 177.49 -68.5, -17.41 in-out in 9.1558 Saltbr-out 5.9622 HRD-in -75.98, -54.72 78.12, -0.13 out-in-out SNCoio in-out ActLoopNT-in 2.9081 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -121.74, 156.48 APE9-dihe-na -76.58, -177.16 APE8-dihe-in -62.22, 124.84 APE8-rot-in 304.94 APE67-dihe-in -57.93, -31.87 -59.46, -41.19 APE12-dist-out 5.2863 APE11-dist-in 8.586 APE10-dist-out 9.3111 APE9-dist-in 3.6782 Q207D None None XRAY 1.32 0.169 0.195 A 301.0 285.0 13 32 22 10 [[207, 497]] 1.0 5s7b TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7HA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,HVB:509,HVB:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.4004 13.3492 BLAminus -122.03, 161.2 75.68, 88.77 -99.68, 25.56 301.4, 178.71 -69.41, -15.19 in-out in 9.2841 Saltbr-out 6.1124 HRD-in -74.82, -53.78 79.5, -0.11 out-in-out SNCoio in-out ActLoopNT-in 2.9554 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.66, 158.62 APE9-dihe-na -71.55, -178.8 APE8-dihe-in -67.44, 125.65 APE8-rot-in 300.35 APE67-dihe-in -57.2, -30.23 -61.33, -40.16 APE12-dist-none 999.0 APE11-dist-out 6.4173 APE10-dist-out 9.333 APE9-dist-in 3.6164 Q207D None None XRAY 1.3 0.158 0.18 A 301.0 284.0 15 32 20 12 [[207, 497]] 1.0 5s7h TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7ZA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,BYZ:510,BYZ:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3715 13.3787 BLAminus -118.29, 164.94 73.01, 90.28 -101.45, 25.18 297.95, 179.49 -66.08, -18.47 in-out in 9.0354 Saltbr-out 5.8164 HRD-in -75.5, -56.61 78.44, 1.56 out-in-out SNCoio in-out ActLoopNT-in 2.884 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.97, 169.25 APE9-dihe-na -61.57, 164.92 APE8-dihe-in -63.28, 125.7 APE8-rot-in 303.7 APE67-dihe-in -57.35, -34.69 -61.46, -39.19 APE12-dist-in 10.5839 APE11-dist-out 6.2834 APE10-dist-out 8.9041 APE9-dist-in 3.732 Q207D None None XRAY 1.3 0.163 0.184 A 301.0 287.0 11 32 23 9 [[207, 497]] 1.0 5s7z TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S81B Q04771 208 499 509.0 LU8:501,XJV:505,XJV:506,XJV:507,XJV:508 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 7.0985 13.4687 BLAminus -122.8, 162.49 76.01, 87.95 -102.27, 24.4 302.62, 170.08 -70.81, -17.85 in-out in 8.7907 Saltbr-out 4.6119 HRD-in -80.16, -52.27 79.27, -5.04 out-in-out SNCoio in-out ActLoopNT-in 2.9443 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.12, 164.98 APE9-dihe-na -61.51, 162.25 APE8-dihe-in -57.76, 127.22 APE8-rot-in 301.4 APE67-dihe-in -60.84, -27.37 -62.01, -41.07 APE12-dist-in 10.3598 APE11-dist-out 6.1972 APE10-dist-out 8.9898 APE9-dist-in 3.8886 Q207D None None XRAY 1.43 0.17 0.196 B 301.0 289.0 3 32 32 0 [[207, 497]] 1.0 5s81 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7CA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,T5Y:509,T5Y:510,T5Y:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3393 13.3454 BLAminus -122.66, 161.69 76.15, 92.72 -104.11, 24.78 300.15, 178.43 -66.33, -20.88 in-out in 9.2312 Saltbr-out 6.1549 HRD-in -76.23, -54.18 77.19, 0.83 out-in-out SNCoio in-out ActLoopNT-in 2.9506 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.75, 170.87 APE9-dihe-na -60.45, 165.58 APE8-dihe-in -64.98, 123.25 APE8-rot-in 303.45 APE67-dihe-in -56.7, -31.98 -63.36, -36.72 APE12-dist-none 999.0 APE11-dist-out 6.251 APE10-dist-out 8.8085 APE9-dist-in 3.7199 Q207D None None XRAY 1.31 0.161 0.179 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s7c TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7IA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,HV2:509,HV2:510,HV2:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.4231 13.4136 BLAminus -121.19, 161.49 77.75, 90.77 -102.55, 26.67 296.81, 175.99 -70.08, -16.54 in-out in 9.1542 Saltbr-out 6.1975 HRD-in -79.1, -52.38 76.17, 1.2 out-in-out SNCoio in-out ActLoopNT-in 2.8872 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.34, 168.68 APE9-dihe-na -65.41, 166.87 APE8-dihe-in -63.35, 124.96 APE8-rot-in 301.24 APE67-dihe-in -56.97, -30.73 -63.49, -38.5 APE12-dist-none 999.0 APE11-dist-out 6.0485 APE10-dist-out 8.8992 APE9-dist-in 3.6905 Q207D None None XRAY 1.3 0.158 0.176 A 301.0 284.0 15 32 19 13 [[207, 497]] 1.0 5s7i TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7TA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,XGJ:509,XGJ:510,XGJ:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3641 13.3581 BLAminus -122.53, 161.24 78.81, 92.17 -103.84, 26.27 299.68, 1.07 -70.27, -17.35 in-out in 9.1872 Saltbr-out 6.1023 HRD-in -73.55, -56.12 78.98, 0.06 out-in-out SNCoio in-out ActLoopNT-in 2.9448 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -126.64, 169.46 APE9-dihe-na -62.74, 163.72 APE8-dihe-in -63.21, 123.01 APE8-rot-in 300.97 APE67-dihe-in -58.38, -31.17 -61.88, -38.7 APE12-dist-none 999.0 APE11-dist-out 6.217 APE10-dist-out 8.8776 APE9-dist-in 3.7084 Q207D None None XRAY 1.3 0.155 0.174 A 301.0 284.0 14 32 20 12 [[207, 497]] 1.0 5s7t TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7YB Q04771 207 499 509.0 LU8:501,XJP:505,XJP:506,XJP:507,XJP:508,XJP:509 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 7.0154 13.4267 BLAminus -126.98, 162.69 75.57, 89.14 -100.94, 21.08 303.3, 173.42 -67.07, -20.24 in-out in 8.8412 Saltbr-out 4.7344 HRD-in -81.6, -53.06 80.61, -4.28 out-in-out SNCoio in-out ActLoopNT-in 2.9288 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.96, 164.75 APE9-dihe-na -61.91, 164.34 APE8-dihe-in -58.26, 128.88 APE8-rot-in 298.27 APE67-dihe-in -57.49, -30.88 -60.34, -41.77 APE12-dist-in 10.3261 APE11-dist-out 6.153 APE10-dist-out 9.0872 APE9-dist-in 3.7656 Q207D None None XRAY 1.37 0.161 0.184 B 301.0 290.0 3 32 32 0 [[207, 497]] 1.0 5s7y TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7RB Q04771 205 499 509.0 LU8:501,XGS:505,XGS:506,XGS:507,XGS:508,XGS:509,XGS:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 6.9508 13.305 BLAminus -123.51, 161.17 75.08, 89.73 -101.63, 18.32 302.56, 179.54 -66.27, -18.2 in-out in 8.7282 Saltbr-out 4.7541 HRD-in -80.45, -51.89 79.75, -1.22 out-in-out SNCoio in-out ActLoopNT-in 2.924 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.67, 165.96 APE9-dihe-na -61.08, 162.39 APE8-dihe-in -58.43, 128.17 APE8-rot-in 299.47 APE67-dihe-in -59.07, -29.26 -60.13, -43.27 APE12-dist-in 10.3121 APE11-dist-out 6.1071 APE10-dist-out 9.0326 APE9-dist-in 3.8788 Q207D None None XRAY 1.46 0.173 0.198 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7r TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S85A Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,XK4:509,XK4:510,XK4:511,XK4:512 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3817 13.3344 BLAminus -122.41, 161.16 77.18, 90.52 -102.57, 24.0 300.65, 177.17 -69.5, -18.6 in-out in 9.1659 Saltbr-out 6.0741 HRD-in -76.19, -53.3 76.63, 0.17 out-in-out SNCoio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -127.51, 169.88 APE9-dihe-na -65.71, 163.81 APE8-dihe-in -61.83, 125.14 APE8-rot-in 302.55 APE67-dihe-in -58.05, -31.45 -63.04, -37.5 APE12-dist-none 999.0 APE11-dist-out 6.228 APE10-dist-out 8.8547 APE9-dist-in 3.7358 Q207D None None XRAY 1.33 0.162 0.182 A 301.0 282.0 16 32 19 13 [[207, 497]] 1.0 5s85 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S8BA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,XFV:509,XFV:510,XFV:511,XFV:512 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3245 13.2716 BLAminus -118.75, 157.39 80.5, 89.5 -103.48, 23.68 297.02, 5.33 -69.81, -17.79 in-out in 9.013 Saltbr-out 5.9816 HRD-in -76.49, -52.01 73.71, 3.51 out-in-out SNCoio in-out ActLoopNT-in 2.8648 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -132.81, 169.84 APE9-dihe-na -47.57, 153.77 APE8-dihe-in -59.87, 123.35 APE8-rot-in 304.85 APE67-dihe-in -51.72, -35.23 -61.3, -40.47 APE12-dist-none 999.0 APE11-dist-out 6.4138 APE10-dist-out 8.8102 APE9-dist-in 3.6992 Q207D None None XRAY 1.64 0.2 0.233 A 301.0 284.0 15 32 19 13 [[207, 497]] 1.0 5s8b TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7RA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,XGS:509,XGS:510,XGS:511,XGS:512,XGS:513 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3785 13.2666 BLAminus -118.49, 160.3 77.59, 89.22 -102.83, 29.26 299.84, 3.52 -70.9, -18.65 in-out in 9.1133 Saltbr-out 6.2461 HRD-in -79.07, -53.38 77.46, -1.57 out-in-out SNCoio in-out ActLoopNT-in 2.9231 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -126.05, 166.06 APE9-dihe-na -58.33, 162.52 APE8-dihe-in -61.2, 125.14 APE8-rot-in 304.32 APE67-dihe-in -53.36, -31.96 -64.07, -40.51 APE12-dist-none 999.0 APE11-dist-out 6.0853 APE10-dist-out 8.9465 APE9-dist-in 3.7151 Q207D None None XRAY 1.46 0.173 0.198 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s7r TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7IB Q04771 205 499 509.0 LU8:501,HV2:505,HV2:506,HV2:507,HV2:508,HV2:509,HV2:510,HV2:511,HV2:512,HV2:513 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 7.0297 13.3467 BLAminus -124.03, 163.17 76.81, 90.06 -103.28, 20.27 301.31, 176.76 -69.97, -14.64 in-out in 8.7537 Saltbr-out 4.763 HRD-in -75.19, -55.72 81.55, -2.41 out-in-out SNCoio in-out ActLoopNT-in 2.9502 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.42, 164.49 APE9-dihe-na -59.34, 164.13 APE8-dihe-in -60.56, 130.0 APE8-rot-in 297.57 APE67-dihe-in -61.93, -26.2 -62.79, -39.84 APE12-dist-in 10.3438 APE11-dist-out 6.121 APE10-dist-out 9.0233 APE9-dist-in 3.8528 Q207D None None XRAY 1.3 0.158 0.176 B 301.0 294.0 1 32 32 0 [[207, 497]] 1.0 5s7i TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S78A Q04771 202 499 509.0 LU8:501,LU8:506,LU8:507,XGV:508,XGV:509,XGV:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Type1 Inactive DFGin 8.3242 13.3553 BLAminus -121.42, 162.3 75.56, 91.97 -103.54, 25.72 302.81, 1.93 -71.55, -16.97 in-out in 9.2716 Saltbr-out 6.2967 HRD-in -75.89, -55.37 78.61, -0.74 out-in-out SNCoio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -123.0, 170.53 APE9-dihe-na -61.1, 164.91 APE8-dihe-in -65.24, 123.82 APE8-rot-in 300.79 APE67-dihe-in -58.43, -30.55 -62.87, -37.3 APE12-dist-in 9.447 APE11-dist-out 6.1418 APE10-dist-out 8.9017 APE9-dist-in 3.6758 Q207D None None XRAY 1.3 0.16 0.177 A 301.0 285.0 13 32 21 11 [[207, 497]] 1.0 5s78 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S81A Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,XJV:510,XJV:511 Type1,Allosteric,Allosteric,Allosteric,Type1 Inactive DFGin 8.3169 13.2896 BLAminus -119.91, 161.36 74.15, 90.65 -102.16, 24.41 299.52, 0.73 -66.2, -16.75 in-out in 9.161 Saltbr-out 6.2167 HRD-in -73.39, -56.79 82.29, -0.98 out-in-out SNCoio in-out ActLoopNT-in 2.9048 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -125.7, 171.05 APE9-dihe-na -60.67, 164.13 APE8-dihe-in -64.52, 125.11 APE8-rot-in 304.88 APE67-dihe-in -56.55, -33.14 -61.08, -40.13 APE12-dist-none 999.0 APE11-dist-out 6.1891 APE10-dist-out 8.8622 APE9-dist-in 3.6802 Q207D None None XRAY 1.43 0.17 0.196 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s81 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S76A Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,02A:509,02A:510 Type1,Allosteric,Allosteric,Allosteric,Type1.5_Back Inactive DFGin 8.3968 13.3521 BLAminus -125.71, 163.24 76.56, 90.11 -103.29, 26.3 299.59, 179.12 -70.47, -16.36 in-out in 9.1694 Saltbr-out 6.1364 HRD-in -78.12, -53.94 78.79, 0.3 out-in-out SNCoio in-out ActLoopNT-in 2.9104 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -121.64, 170.51 APE9-dihe-na -62.2, 167.24 APE8-dihe-in -63.35, 123.08 APE8-rot-in 302.24 APE67-dihe-in -58.65, -29.05 -63.37, -35.67 APE12-dist-none 999.0 APE11-dist-out 6.2237 APE10-dist-out 8.9115 APE9-dist-in 3.6733 Q207D None None XRAY 1.31 0.156 0.173 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s76 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7LB Q04771 205 499 509.0 LU8:501,XHJ:505,XHJ:506,XHJ:507,XHJ:508 Type1,Allosteric,Allosteric,Allosteric,Type3 Inactive DFGin 7.1106 13.3904 BLAminus -125.42, 162.47 77.36, 89.52 -102.53, 17.7 300.76, 174.49 -63.63, -17.96 in-out in 8.7862 Saltbr-out 4.4575 HRD-in -76.1, -52.38 79.68, -4.98 out-in-out SNCoio in-out ActLoopNT-in 2.9355 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.61, 167.49 APE9-dihe-na -61.83, 166.04 APE8-dihe-in -62.17, 127.63 APE8-rot-in 299.54 APE67-dihe-in -59.75, -27.49 -60.2, -41.98 APE12-dist-in 10.4367 APE11-dist-out 6.3974 APE10-dist-out 9.019 APE9-dist-in 3.8941 Q207D None None XRAY 1.36 0.167 0.188 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7l TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S84A Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,XK1:509 Type1,Allosteric,Allosteric,Type1 Inactive DFGin 8.3364 13.4392 BLAminus -118.42, 161.89 75.73, 89.87 -101.05, 26.48 297.86, 0.33 -68.45, -15.46 in-out in 9.1253 Saltbr-out 6.0801 HRD-in -77.01, -56.17 80.15, -0.22 out-in-out SNCoio in-out ActLoopNT-in 2.8952 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.67, 170.99 APE9-dihe-na -62.03, 164.12 APE8-dihe-in -62.23, 123.92 APE8-rot-in 305.79 APE67-dihe-in -60.01, -30.93 -61.35, -38.64 APE12-dist-none 999.0 APE11-dist-out 6.1334 APE10-dist-out 8.8394 APE9-dist-in 3.6798 Q207D None None XRAY 1.35 0.166 0.191 A 301.0 284.0 15 32 19 13 [[207, 497]] 1.0 5s84 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S83A Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,XJY:510 Type1,Allosteric,Allosteric,Type3 Inactive DFGin 8.4423 13.2233 BLAminus -121.45, 166.08 75.52, 89.79 -103.21, 23.07 300.9, 0.69 -66.79, -19.18 in-out in 8.9661 Saltbr-out 5.6322 HRD-in -77.39, -55.22 76.55, 2.24 out-in-out SNCoio in-out ActLoopNT-in 2.9096 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.02, 170.52 APE9-dihe-na -63.69, 168.74 APE8-dihe-in -66.61, 121.49 APE8-rot-in 303.57 APE67-dihe-in -53.26, -35.15 -59.02, -40.84 APE12-dist-none 999.0 APE11-dist-out 6.3416 APE10-dist-out 8.8704 APE9-dist-in 3.7557 Q207D None None XRAY 1.33 0.161 0.185 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s83 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7OB Q04771 205 499 509.0 LU8:501,XJJ:505 Type1,Type1 Inactive DFGin 6.984 13.3823 BLAminus -123.75, 162.83 73.51, 87.08 -99.67, 20.63 303.58, 175.53 -70.31, -13.4 in-out in 8.8535 Saltbr-out 4.7545 HRD-in -78.42, -53.12 79.9, -3.76 out-in-out SNCoio in-out ActLoopNT-in 2.9423 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.12, 167.38 APE9-dihe-na -65.37, 165.19 APE8-dihe-in -58.94, 129.63 APE8-rot-in 299.85 APE67-dihe-in -59.51, -26.9 -60.64, -42.85 APE12-dist-in 10.3308 APE11-dist-out 6.1918 APE10-dist-out 9.0274 APE9-dist-in 3.8558 Q207D None None XRAY 1.43 0.165 0.189 B 301.0 295.0 0 32 32 0 [[207, 497]] 1.0 5s7o TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S85B Q04771 207 499 509.0 LU8:501,XK4:505,XK4:506,XK4:507 Type1,Type1,Allosteric,Allosteric Inactive DFGin 6.9932 13.3738 BLAminus -127.18, 161.1 77.88, 88.72 -101.83, 19.04 301.72, 175.14 -66.37, -15.29 in-out in 8.7132 Saltbr-out 4.6046 HRD-in -77.44, -53.87 79.87, -4.46 out-in-out SNCoio in-out ActLoopNT-in 2.9328 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.46, 164.3 APE9-dihe-na -59.94, 165.51 APE8-dihe-in -60.21, 126.73 APE8-rot-in 299.02 APE67-dihe-in -60.44, -25.63 -60.52, -40.57 APE12-dist-in 10.3512 APE11-dist-out 6.2103 APE10-dist-out 9.0332 APE9-dist-in 3.8112 Q207D None None XRAY 1.33 0.162 0.182 B 301.0 290.0 3 32 32 0 [[207, 497]] 1.0 5s85 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S76B Q04771 205 499 509.0 LU8:501,02A:505 Type1,Type1.5_Back Inactive DFGin 7.0455 13.388 BLAminus -126.37, 161.8 77.8, 87.16 -99.2, 20.64 303.2, 173.97 -68.3, -17.34 in-out in 8.8877 Saltbr-out 4.7352 HRD-in -77.8, -54.12 78.31, -2.4 out-in-out SNCoio in-out ActLoopNT-in 2.9422 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.39, 162.33 APE9-dihe-na -57.18, 164.84 APE8-dihe-in -61.8, 127.01 APE8-rot-in 299.22 APE67-dihe-in -57.98, -30.25 -60.93, -39.7 APE12-dist-in 10.3885 APE11-dist-out 6.1918 APE10-dist-out 9.0776 APE9-dist-in 3.7583 Q207D None None XRAY 1.31 0.156 0.173 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s76 TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S9KB Q04771 205 499 509.0 LU8:501,YV4:505 Type1,Type3 Inactive DFGin 6.8994 13.3113 BLAminus -124.0, 163.62 77.74, 89.17 -103.64, 24.26 305.37, 1.01 -72.01, -17.07 in-out in 8.8119 Saltbr-out 4.6602 HRD-in -80.23, -51.12 77.76, -2.54 out-in-out SNCoio in-out ActLoopNT-in 2.9224 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.95, 165.67 APE9-dihe-na -60.95, 168.37 APE8-dihe-in -63.37, 128.29 APE8-rot-in 299.42 APE67-dihe-in -54.29, -31.02 -58.7, -45.73 APE12-dist-in 10.3307 APE11-dist-out 6.1855 APE10-dist-out 8.9921 APE9-dist-in 3.6866 Q207D None None XRAY 1.35 0.176 0.2 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s9k TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1

Ligand: LU8

Total number of chains: 100
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 90 90.0% 6SRHB
DFGout None 10 10.0% 8XFYA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYA P51812 58 358 740.0 A1LU8:401 Type1 Inactive DFGout 13.2049 7.3468 None -84.69, 175.04 -98.49, -2.97 -56.06, -41.49 288.51, 111.93 -88.04, -1.58 out-out out 13.584 Saltbr-out 12.4908 HRD-out -102.98, 108.87 -62.66, -66.03 out-out-out SNCooo out-out ActLoopNT-out 5.2899 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -171.34, 174.53 APE9-dihe-na 132.9, 150.52 APE8-dihe-in -54.44, 119.7 APE8-rot-in 325.6 APE67-dihe-in -67.51, -35.24 -72.39, -24.23 APE12-dist-none 999.0 APE11-dist-out 15.3012 APE10-dist-out 13.362 APE9-dist-out 6.3968 None None None XRAY 3.2 0.233 0.303 A 320.0 289.0 12 28 19 9 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYB P51812 59 358 740.0 A1LU8:401 Type1 Inactive DFGout 12.4755 7.6225 None -79.21, 172.69 -104.74, 14.38 -72.96, -37.65 288.72, 121.74 -83.1, -14.53 out-out out 13.02 Saltbr-out 10.2513 HRD-out -85.11, 105.26 -64.66, -55.07 out-out-out SNCooo out-out ActLoopNT-out 5.1807 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -141.21, 158.45 APE9-dihe-na 119.59, 160.83 APE8-dihe-in -64.8, 132.56 APE8-rot-out 38.16 APE67-dihe-in -76.3, -33.52 -81.38, -10.91 APE12-dist-none 999.0 APE11-dist-out 15.9119 APE10-dist-out 12.4271 APE9-dist-out 6.3691 None None None XRAY 3.2 0.233 0.303 B 320.0 277.0 23 28 18 10 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYC P51812 61 358 740.0 A1LU8:401 Type1 Inactive DFGout 13.0072 7.4047 None -74.08, -176.12 -117.42, 16.75 -70.92, -31.59 288.86, 115.13 -89.42, -33.94 none-none none 999.0 Saltbr-none 999.0 HRD-out -99.11, 116.77 -79.3, -60.22 none-out-out SNCnoo out-out ActLoopNT-out 5.1388 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -154.86, 91.8 APE9-dihe-na -163.03, 159.53 APE8-dihe-in -69.77, 116.03 APE8-rot-in 309.84 APE67-dihe-in -63.05, -25.35 -70.36, -29.8 APE12-dist-none 999.0 APE11-dist-out 15.6924 APE10-dist-out 13.2566 APE9-dist-out 6.1853 None None None XRAY 3.2 0.233 0.303 C 320.0 272.0 26 28 18 10 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYD P51812 63 348 740.0 A1LU8:401 Type1 Inactive DFGout 12.6801 7.7179 None -85.23, 171.03 -99.91, 5.18 -66.56, -47.9 288.97, 119.73 -68.87, -42.49 none-none none 999.0 Saltbr-none 999.0 HRD-out -108.97, 107.04 -79.62, 147.57 none-out-out SNCnoo out-out ActLoopNT-out 5.0043 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -160.66, -177.37 APE9-dihe-na 101.82, 157.81 APE8-dihe-in -62.84, 132.59 APE8-rot-out 47.92 APE67-dihe-in -68.43, -26.54 -77.35, -22.1 APE12-dist-none 999.0 APE11-dist-out 16.0048 APE10-dist-out 13.6407 APE9-dist-out 7.2804 None None None XRAY 3.2 0.233 0.303 D 320.0 260.0 26 28 18 10 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYE P51812 64 348 740.0 A1LU8:401 Type1 Inactive DFGout 12.8137 7.7319 None -79.79, 173.69 -104.44, 5.05 -67.56, -37.65 296.33, 117.93 -76.73, -31.97 none-none none 999.0 Saltbr-none 999.0 HRD-out -107.95, 111.24 -79.69, -31.85 none-out-out SNCnoo out-out ActLoopNT-out 5.217 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooi APE10-dihe-na -171.13, 156.06 APE9-dihe-na 118.15, 155.77 APE8-dihe-in -55.33, 128.86 APE8-rot-out 36.52 APE67-dihe-in -70.55, -22.72 -79.46, -18.88 APE12-dist-none 999.0 APE11-dist-out 16.5561 APE10-dist-out 12.7625 APE9-dist-in 5.5786 None None None XRAY 3.2 0.233 0.303 E 320.0 261.0 24 28 19 9 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYF P51812 63 345 740.0 A1LU8:401 Type1 Inactive DFGout 12.7435 7.4714 None -95.59, -178.42 -108.18, 9.34 -70.41, -40.72 293.14, 115.72 -77.9, -28.8 none-none none 999.0 Saltbr-none 999.0 HRD-out -100.4, 115.65 -68.34, -48.2 none-out-out SNCnoo out-out ActLoopNT-out 5.1559 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -160.1, 173.9 APE9-dihe-na 114.4, 160.81 APE8-dihe-in -56.13, 119.9 APE8-rot-out 41.37 APE67-dihe-in -71.03, -16.28 -73.87, -18.19 APE12-dist-none 999.0 APE11-dist-out 15.3915 APE10-dist-out 13.539 APE9-dist-out 6.404 None None None XRAY 3.2 0.233 0.303 F 320.0 255.0 28 28 17 11 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYG P51812 59 346 740.0 A1LU8:401 Type1 Inactive DFGout 12.937 7.2256 None -78.16, 176.02 -98.19, 0.09 -62.25, -40.75 291.8, 111.06 -81.64, -19.61 in-out in 7.8808 Saltbr-out 5.486 HRD-out -91.07, 110.45 -88.21, -3.19 out-out-out SNCooo out-out ActLoopNT-out 5.1639 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -71.01, 158.33 APE9-dihe-na 129.65, 145.56 APE8-dihe-in -72.78, 126.88 APE8-rot-in 303.8 APE67-dihe-in -65.24, -40.51 -67.91, -29.47 APE12-dist-none 999.0 APE11-dist-out 16.1451 APE10-dist-out 12.0692 APE9-dist-in 4.6444 None None None XRAY 3.2 0.233 0.303 G 320.0 276.0 12 28 18 10 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYH P51812 59 348 740.0 A1LU8:401 Type1 Inactive DFGout 13.3745 7.7126 None -77.26, -179.45 -100.74, 0.21 -62.05, -41.28 291.33, 112.54 -80.3, -18.96 out-out out 12.403 Saltbr-out 7.8685 HRD-out -114.7, 107.73 -80.32, -3.28 out-out-out SNCooo out-out ActLoopNT-out 5.5612 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooi APE10-dihe-na -169.14, 166.07 APE9-dihe-na 97.31, 158.5 APE8-dihe-in -62.25, 138.33 APE8-rot-out 53.1 APE67-dihe-in -70.31, -30.08 -88.76, -15.85 APE12-dist-none 999.0 APE11-dist-out 15.6879 APE10-dist-out 12.1686 APE9-dist-in 5.1187 None None None XRAY 3.2 0.233 0.303 H 320.0 277.0 13 28 18 10 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYI P51812 63 348 740.0 A1LU8:401 Type1 Inactive DFGout 12.4851 7.3943 None -79.8, 178.19 -107.54, 4.76 -62.98, -39.18 294.19, 109.04 -76.4, -38.16 none-none none 999.0 Saltbr-none 999.0 HRD-out -110.77, 98.18 -69.66, 134.16 none-out-out SNCnoo out-out ActLoopNT-out 4.9415 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -128.64, 168.96 APE9-dihe-na 103.76, 142.33 APE8-dihe-in -52.02, 130.9 APE8-rot-out 52.96 APE67-dihe-in -63.86, -32.68 -78.41, -20.46 APE12-dist-none 999.0 APE11-dist-out 16.5462 APE10-dist-out 12.6058 APE9-dist-out 6.6092 None None None XRAY 3.2 0.233 0.303 I 320.0 260.0 26 28 18 10 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYJ P51812 65 347 740.0 A1LU8:401 Type1 Inactive DFGout 12.6806 7.2532 None -82.1, 175.26 -103.79, -3.59 -58.74, -48.51 291.22, 109.94 -83.23, -7.51 none-none none 999.0 Saltbr-none 999.0 HRD-out -111.91, 105.75 -75.45, -19.05 none-out-out SNCnoo out-out ActLoopNT-out 5.0033 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -112.59, 166.79 APE9-dihe-na 114.55, 148.33 APE8-dihe-in -68.28, 140.99 APE8-rot-in 305.08 APE67-dihe-in -73.95, -40.89 -90.2, -12.76 APE12-dist-none 999.0 APE11-dist-out 16.5618 APE10-dist-out 12.8633 APE9-dist-in 5.003 None None None XRAY 3.2 0.233 0.303 J 320.0 257.0 26 28 18 10 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
TKL ACVR1 ACVR1_HUMAN 5S7QB Q04771 205 499 509.0 XJM:1801,LU8:1802,XJM:1806 Allosteric,Type1,Allosteric Inactive DFGin 7.0354 13.341 BLAminus -124.49, 160.57 78.3, 88.59 -102.07, 16.77 299.19, 176.61 -55.48, -25.66 in-out in 8.6067 Saltbr-out 4.5008 HRD-in -84.23, -49.81 75.94, -2.06 out-in-out SNCoio in-out ActLoopNT-in 2.8845 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.81, 167.47 APE9-dihe-na -59.06, 164.28 APE8-dihe-in -59.12, 123.47 APE8-rot-in 303.32 APE67-dihe-in -63.13, -25.62 -55.86, -41.03 APE12-dist-in 10.2953 APE11-dist-out 6.5068 APE10-dist-out 8.8401 APE9-dist-in 3.7438 Q207D None None XRAY 1.53 0.209 0.243 B 301.0 291.0 4 32 32 0 [[207, 497]] 1.0 5s7q Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S77B Q04771 205 499 509.0 LU8:501 Type1 Inactive DFGin 7.0308 13.4527 BLAminus -124.57, 162.89 76.44, 87.16 -99.57, 19.41 300.08, 174.78 -68.76, -14.31 in-out in 8.8527 Saltbr-out 4.6527 HRD-in -77.29, -55.2 78.52, -0.63 out-in-out SNCoio in-out ActLoopNT-in 2.946 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.24, 166.6 APE9-dihe-na -61.81, 164.74 APE8-dihe-in -60.61, 127.64 APE8-rot-in 298.26 APE67-dihe-in -59.97, -28.12 -61.67, -40.13 APE12-dist-in 10.3703 APE11-dist-out 6.2089 APE10-dist-out 8.9958 APE9-dist-in 3.8238 Q207D None None XRAY 1.31 0.166 0.185 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s77 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S78B Q04771 208 499 509.0 LU8:501 Type1 Inactive DFGin 6.9916 13.4038 BLAminus -126.64, 164.14 74.77, 87.97 -101.18, 22.29 302.33, 177.25 -70.25, -15.52 in-out in 8.8007 Saltbr-out 4.6843 HRD-in -78.72, -53.62 78.73, -3.65 out-in-out SNCoio in-out ActLoopNT-in 2.9471 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.7, 165.64 APE9-dihe-na -61.72, 165.79 APE8-dihe-in -60.78, 129.07 APE8-rot-in 300.39 APE67-dihe-in -58.83, -27.2 -62.73, -40.71 APE12-dist-in 10.2054 APE11-dist-out 6.245 APE10-dist-out 9.0468 APE9-dist-in 3.86 Q207D None None XRAY 1.3 0.16 0.177 B 301.0 292.0 0 32 32 0 [[207, 497]] 1.0 5s78 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S79B Q04771 208 498 509.0 LU8:501 Type1 Inactive DFGin 6.949 13.4088 BLAminus -122.03, 163.17 76.24, 92.19 -103.59, 21.82 301.57, 173.56 -69.99, -14.55 in-out in 8.6068 Saltbr-out 3.7757 HRD-in -77.29, -54.6 79.65, 0.11 out-in-out SNCoio in-out ActLoopNT-in 2.9027 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -123.19, 173.51 APE9-dihe-na -67.77, 168.43 APE8-dihe-in -60.9, 124.36 APE8-rot-in 301.89 APE67-dihe-in -54.42, -27.95 -56.48, -46.08 APE12-dist-in 10.3631 APE11-dist-out 6.6445 APE10-dist-out 8.916 APE9-dist-in 3.7495 Q207D None None XRAY 1.5 0.18 0.206 B 301.0 288.0 3 32 32 0 [[207, 497]] 1.0 5s79 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7GB Q04771 207 499 509.0 LU8:501 Type1 Inactive DFGin 6.6407 13.4949 BLAminus -119.72, 159.88 82.75, 87.21 -98.63, 18.92 305.17, 0.99 -67.48, -19.33 in-out in 9.0173 Saltbr-out 4.9584 HRD-in -77.01, -50.93 75.96, 1.34 out-in-none SNCoin in-none ActLoopNT-in 2.9658 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -89.52, 148.19 APE9-dihe-na 117.39, 161.66 APE8-dihe-in -69.4, 128.02 APE8-rot-in 308.42 APE67-dihe-in -59.26, -33.51 -60.94, -38.65 APE12-dist-none 999.0 APE11-dist-in 11.6619 APE10-dist-in 5.8166 APE9-dist-in 3.9424 Q207D None None XRAY 1.78 0.206 0.252 B 301.0 281.0 12 32 24 8 [[207, 497]] 1.0 5s7g Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7HB Q04771 205 499 509.0 LU8:501 Type1 Inactive DFGin 7.002 13.3868 BLAminus -126.96, 163.26 76.81, 86.99 -100.87, 23.04 301.4, 176.52 -72.34, -14.12 in-out in 8.8346 Saltbr-out 4.7589 HRD-in -77.49, -53.08 77.02, -2.86 out-in-out SNCoio in-out ActLoopNT-in 2.9428 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.19, 165.21 APE9-dihe-na -62.02, 164.93 APE8-dihe-in -59.21, 129.08 APE8-rot-in 298.47 APE67-dihe-in -58.12, -30.1 -64.15, -39.55 APE12-dist-in 10.3133 APE11-dist-out 6.1622 APE10-dist-out 9.011 APE9-dist-in 3.7279 Q207D None None XRAY 1.3 0.158 0.18 B 301.0 293.0 2 32 32 0 [[207, 497]] 1.0 5s7h Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7JB Q04771 206 499 509.0 LU8:501 Type1 Inactive DFGin 6.9724 13.3899 BLAminus -125.59, 163.92 74.27, 89.45 -104.09, 21.89 302.89, 178.4 -70.85, -13.4 in-out in 8.7911 Saltbr-out 4.7228 HRD-in -74.57, -55.28 81.04, -2.31 out-in-out SNCoio in-out ActLoopNT-in 2.9444 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.08, 165.49 APE9-dihe-na -60.51, 165.0 APE8-dihe-in -60.32, 128.5 APE8-rot-in 300.26 APE67-dihe-in -54.83, -31.02 -61.2, -43.09 APE12-dist-in 10.3546 APE11-dist-out 6.1672 APE10-dist-out 9.0326 APE9-dist-in 3.8062 Q207D None None XRAY 1.31 0.159 0.181 B 301.0 291.0 3 32 32 0 [[207, 497]] 1.0 5s7j Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7PB Q04771 208 499 509.0 LU8:501 Type1 Inactive DFGin 7.041 13.4201 BLAminus -127.32, 160.61 79.2, 88.36 -101.38, 20.66 301.74, 174.56 -69.08, -14.59 in-out in 8.8375 Saltbr-out 4.7494 HRD-in -79.58, -51.94 76.5, -1.66 out-in-out SNCoio in-out ActLoopNT-in 2.9461 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.23, 166.15 APE9-dihe-na -60.81, 164.72 APE8-dihe-in -59.48, 128.85 APE8-rot-in 300.38 APE67-dihe-in -62.62, -25.57 -64.98, -36.96 APE12-dist-in 10.458 APE11-dist-out 6.1919 APE10-dist-out 8.9709 APE9-dist-in 3.8702 Q207D None None XRAY 1.31 0.158 0.176 B 301.0 289.0 3 32 32 0 [[207, 497]] 1.0 5s7p Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7WB Q04771 205 499 509.0 LU8:501 Type1 Inactive DFGin 7.0298 13.4008 BLAminus -127.76, 159.78 80.36, 85.76 -99.88, 21.09 305.52, 179.19 -65.9, -24.32 in-out in 8.9404 Saltbr-out 4.8194 HRD-in -77.42, -54.04 83.37, -7.62 out-in-out SNCoio in-out ActLoopNT-in 2.9581 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.09, 164.43 APE9-dihe-na -60.72, 165.96 APE8-dihe-in -63.25, 128.46 APE8-rot-in 296.55 APE67-dihe-in -59.57, -28.14 -60.1, -41.66 APE12-dist-in 10.3172 APE11-dist-out 6.2471 APE10-dist-out 9.0709 APE9-dist-in 3.8111 Q207D None None XRAY 1.33 0.164 0.186 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7w Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S83B Q04771 205 499 509.0 LU8:501 Type1 Inactive DFGin 7.0334 13.4784 BLAminus -124.19, 162.22 78.06, 86.57 -101.53, 19.96 300.51, 175.3 -64.11, -18.65 in-out in 8.8905 Saltbr-out 4.771 HRD-in -75.73, -55.05 82.15, -4.6 out-in-out SNCoio in-out ActLoopNT-in 2.9542 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.26, 164.39 APE9-dihe-na -61.1, 166.22 APE8-dihe-in -61.61, 128.13 APE8-rot-in 300.62 APE67-dihe-in -58.81, -29.24 -62.24, -41.18 APE12-dist-in 10.4236 APE11-dist-out 6.2854 APE10-dist-out 9.037 APE9-dist-in 3.8558 Q207D None None XRAY 1.33 0.161 0.185 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s83 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S84B Q04771 206 499 509.0 LU8:501 Type1 Inactive DFGin 6.9876 13.4478 BLAminus -125.42, 163.93 74.98, 89.22 -103.06, 18.19 302.78, 175.41 -63.64, -17.13 in-out in 8.8196 Saltbr-out 4.6677 HRD-in -75.34, -54.28 80.29, -2.12 out-in-out SNCoio in-out ActLoopNT-in 2.9161 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.41, 168.09 APE9-dihe-na -59.7, 163.97 APE8-dihe-in -58.67, 126.71 APE8-rot-in 301.06 APE67-dihe-in -57.69, -26.63 -61.25, -41.61 APE12-dist-in 10.3451 APE11-dist-out 6.2 APE10-dist-out 9.0135 APE9-dist-in 3.8636 Q207D None None XRAY 1.35 0.166 0.191 B 301.0 291.0 3 32 32 0 [[207, 497]] 1.0 5s84 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S89B Q04771 205 499 509.0 LU8:501 Type1 Inactive DFGin 6.984 13.3612 BLAminus -124.97, 163.75 76.76, 88.69 -102.06, 21.8 303.74, 177.29 -68.27, -19.19 in-out in 8.8655 Saltbr-out 4.7724 HRD-in -81.65, -52.32 78.48, -1.17 out-in-out SNCoio in-out ActLoopNT-in 2.9216 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.77, 165.98 APE9-dihe-na -60.57, 167.11 APE8-dihe-in -63.21, 128.67 APE8-rot-in 299.1 APE67-dihe-in -57.43, -30.6 -61.18, -42.41 APE12-dist-in 10.2763 APE11-dist-out 6.1981 APE10-dist-out 8.9916 APE9-dist-in 3.7099 Q207D None None XRAY 1.3 0.156 0.174 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s89 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6SRHA Q04771 201 499 509.0 LU8:501 Type1 Inactive DFGin 8.3373 13.4422 BLAminus -122.57, 162.03 75.26, 88.46 -99.42, 24.23 300.0, 175.86 -68.83, -17.25 in-out in 9.2713 Saltbr-out 6.1836 HRD-in -78.85, -52.97 79.59, -0.55 out-in-out SNCoio in-out ActLoopNT-in 2.9523 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.6, 171.91 APE9-dihe-na -65.69, 166.15 APE8-dihe-in -64.37, 126.3 APE8-rot-in 301.19 APE67-dihe-in -57.05, -29.89 -63.28, -37.95 APE12-dist-in 10.9956 APE11-dist-out 6.191 APE10-dist-out 8.8899 APE9-dist-in 3.6719 Q207D None None XRAY 1.25 0.134 0.16 A 301.0 288.0 11 32 21 11 [[207, 497]] 1.0 6srh Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7BB Q04771 205 499 509.0 LU8:501,XH7:506 Type1,Allosteric Inactive DFGin 7.0215 13.362 BLAminus -121.46, 161.83 78.44, 88.34 -102.47, 19.49 301.42, 173.88 -65.45, -20.59 in-out in 8.7895 Saltbr-out 4.6853 HRD-in -74.99, -55.16 78.67, -0.58 out-in-out SNCoio in-out ActLoopNT-in 2.9128 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.52, 156.89 APE9-dihe-na -51.95, 170.55 APE8-dihe-in -69.31, 128.28 APE8-rot-in 299.94 APE67-dihe-in -63.25, -25.99 -60.99, -39.27 APE12-dist-in 10.4037 APE11-dist-out 6.3927 APE10-dist-out 9.0949 APE9-dist-in 3.8072 Q207D None None XRAY 1.32 0.169 0.195 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7b Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7CB Q04771 205 499 509.0 LU8:501,T5Y:505 Type1,Allosteric Inactive DFGin 7.0621 13.3895 BLAminus -126.3, 161.98 79.71, 89.61 -103.06, 23.5 302.55, 173.63 -67.99, -21.1 in-out in 8.8544 Saltbr-out 4.7577 HRD-in -77.43, -53.45 76.82, -0.13 out-in-out SNCoio in-out ActLoopNT-in 2.9125 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.01, 166.06 APE9-dihe-na -60.91, 165.47 APE8-dihe-in -62.27, 130.39 APE8-rot-in 299.14 APE67-dihe-in -63.71, -26.19 -64.69, -37.05 APE12-dist-in 10.3644 APE11-dist-out 6.2378 APE10-dist-out 8.9937 APE9-dist-in 3.938 Q207D None None XRAY 1.31 0.161 0.179 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7c Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7DB Q04771 205 499 509.0 LU8:501,XHD:505 Type1,Allosteric Inactive DFGin 6.9999 13.3494 BLAminus -123.42, 163.32 74.65, 90.04 -104.07, 23.56 302.54, 177.54 -72.51, -12.63 in-out in 8.7588 Saltbr-out 4.7023 HRD-in -77.61, -53.61 80.79, -1.13 out-in-out SNCoio in-out ActLoopNT-in 2.9693 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.29, 164.81 APE9-dihe-na -57.91, 162.72 APE8-dihe-in -60.44, 129.2 APE8-rot-in 299.64 APE67-dihe-in -59.07, -29.49 -62.4, -40.3 APE12-dist-in 10.3581 APE11-dist-out 6.219 APE10-dist-out 9.0261 APE9-dist-in 3.7864 Q207D None None XRAY 1.31 0.165 0.185 B 301.0 295.0 0 32 32 0 [[207, 497]] 1.0 5s7d Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7EB Q04771 205 499 509.0 LU8:501,XEA:505 Type1,Allosteric Inactive DFGin 7.0009 13.4563 BLAminus -126.91, 163.64 73.07, 91.25 -103.42, 21.63 301.95, 174.37 -67.85, -18.9 in-out in 8.8128 Saltbr-out 4.7223 HRD-in -77.73, -53.3 79.65, -3.06 out-in-out SNCoio in-out ActLoopNT-in 2.929 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.66, 166.82 APE9-dihe-na -61.55, 164.95 APE8-dihe-in -59.98, 129.55 APE8-rot-in 299.19 APE67-dihe-in -58.01, -29.13 -63.05, -41.4 APE12-dist-in 10.2582 APE11-dist-out 6.2149 APE10-dist-out 9.0083 APE9-dist-in 3.801 Q207D None None XRAY 1.32 0.168 0.189 B 301.0 293.0 2 32 32 0 [[207, 497]] 1.0 5s7e Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7KB Q04771 205 499 509.0 LU8:501,XEJ:504 Type1,Allosteric Inactive DFGin 6.9806 13.2701 BLAminus -124.3, 164.86 75.9, 87.47 -102.78, 21.12 305.49, 0.35 -65.97, -18.91 in-out in 8.8339 Saltbr-out 4.6466 HRD-in -79.74, -53.13 79.6, -2.25 out-in-out SNCoio in-out ActLoopNT-in 2.8589 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.28, 163.22 APE9-dihe-na -60.14, 169.9 APE8-dihe-in -64.39, 127.18 APE8-rot-in 298.46 APE67-dihe-in -57.76, -29.28 -59.11, -42.6 APE12-dist-in 10.4215 APE11-dist-out 6.3009 APE10-dist-out 8.9738 APE9-dist-in 3.6767 None None None XRAY 1.31 0.162 0.188 B 301.0 293.0 2 32 32 0 [[207, 497]] 1.0 5s7k Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7MB Q04771 208 499 509.0 LU8:501,HVK:505 Type1,Allosteric Inactive DFGin 7.009 13.3206 BLAminus -124.89, 160.91 76.23, 87.23 -100.03, 22.28 300.52, 174.89 -68.18, -14.07 in-out in 8.451 Saltbr-out 4.2021 HRD-in -76.72, -54.96 80.02, -2.85 out-in-out SNCoio in-out ActLoopNT-in 2.9243 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.58, 168.17 APE9-dihe-na -62.95, 162.95 APE8-dihe-in -58.04, 127.45 APE8-rot-in 298.56 APE67-dihe-in -59.18, -25.23 -62.3, -40.69 APE12-dist-in 10.3695 APE11-dist-out 6.2098 APE10-dist-out 8.9384 APE9-dist-in 3.8142 Q207D None None XRAY 1.32 0.171 0.195 B 301.0 290.0 2 32 32 0 [[207, 497]] 1.0 5s7m Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7NB Q04771 207 499 509.0 LU8:501,2AI:505 Type1,Allosteric Inactive DFGin 7.0053 13.4202 BLAminus -126.13, 161.61 77.78, 88.49 -101.78, 20.71 303.39, 175.45 -67.06, -19.53 in-out in 8.8596 Saltbr-out 4.7161 HRD-in -78.53, -54.27 81.6, -6.08 out-in-out SNCoio in-out ActLoopNT-in 2.9573 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.2, 164.62 APE9-dihe-na -57.6, 161.75 APE8-dihe-in -58.85, 126.75 APE8-rot-in 300.18 APE67-dihe-in -61.19, -26.66 -59.93, -40.36 APE12-dist-in 10.2703 APE11-dist-out 6.1513 APE10-dist-out 9.0073 APE9-dist-in 3.7557 Q207D None None XRAY 1.3 0.163 0.186 B 301.0 290.0 3 32 32 0 [[207, 497]] 1.0 5s7n Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7SB Q04771 205 499 509.0 LU8:501,09V:505 Type1,Allosteric Inactive DFGin 6.9873 13.4064 BLAminus -127.22, 162.49 75.55, 89.77 -103.58, 21.52 302.17, 178.46 -71.16, -15.05 in-out in 8.8785 Saltbr-out 4.7655 HRD-in -78.6, -54.23 80.1, -1.5 out-in-out SNCoio in-out ActLoopNT-in 2.9249 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.31, 165.17 APE9-dihe-na -61.08, 163.96 APE8-dihe-in -59.96, 128.29 APE8-rot-in 298.36 APE67-dihe-in -59.32, -26.33 -61.06, -42.91 APE12-dist-in 10.2601 APE11-dist-out 6.1893 APE10-dist-out 9.0191 APE9-dist-in 3.7777 Q207D None None XRAY 1.3 0.153 0.171 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7s Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7VB Q04771 205 499 509.0 LU8:501,XH1:505 Type1,Allosteric Inactive DFGin 7.0144 13.5121 BLAminus -126.76, 162.04 76.91, 90.47 -102.68, 21.03 302.06, 175.32 -69.9, -15.12 in-out in 8.9289 Saltbr-out 4.7899 HRD-in -78.61, -53.05 79.7, -1.04 out-in-out SNCoio in-out ActLoopNT-in 2.9267 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.43, 165.76 APE9-dihe-na -60.04, 163.83 APE8-dihe-in -61.01, 129.39 APE8-rot-in 297.49 APE67-dihe-in -59.56, -27.34 -62.0, -41.39 APE12-dist-in 10.2933 APE11-dist-out 6.1833 APE10-dist-out 9.0048 APE9-dist-in 3.8521 Q207D None None XRAY 1.31 0.154 0.172 B 301.0 291.0 4 32 32 0 [[207, 497]] 1.0 5s7v Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7XB Q04771 205 499 509.0 LU8:501,LGA:505 Type1,Allosteric Inactive DFGin 7.0314 13.379 BLAminus -128.0, 163.2 78.06, 89.3 -102.46, 20.69 301.92, 175.18 -69.56, -15.46 in-out in 8.8274 Saltbr-out 4.6398 HRD-in -76.89, -56.14 80.13, -1.68 out-in-out SNCoio in-out ActLoopNT-in 2.9186 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.04, 166.03 APE9-dihe-na -61.79, 165.52 APE8-dihe-in -59.06, 127.18 APE8-rot-in 299.22 APE67-dihe-in -59.1, -28.73 -61.83, -40.56 APE12-dist-in 10.3779 APE11-dist-out 6.1653 APE10-dist-out 8.945 APE9-dist-in 3.807 Q207D None None XRAY 1.3 0.151 0.169 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7x Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7ZB Q04771 205 499 509.0 LU8:501,BYZ:505 Type1,Allosteric Inactive DFGin 6.9632 13.3741 BLAminus -125.8, 161.65 77.14, 88.32 -102.44, 23.35 302.89, 177.91 -73.03, -13.12 in-out in 8.7708 Saltbr-out 4.7211 HRD-in -76.79, -54.43 80.82, -3.64 out-in-out SNCoio in-out ActLoopNT-in 2.9201 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.61, 165.38 APE9-dihe-na -60.57, 163.68 APE8-dihe-in -58.84, 127.79 APE8-rot-in 300.37 APE67-dihe-in -58.11, -27.66 -62.19, -41.34 APE12-dist-in 10.3506 APE11-dist-out 6.1474 APE10-dist-out 9.0017 APE9-dist-in 3.8366 Q207D None None XRAY 1.3 0.163 0.184 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7z Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S82B Q04771 205 499 509.0 LU8:501,LAC:505 Type1,Allosteric Inactive DFGin 6.6555 13.3978 BLAminus -126.04, 165.16 75.17, 84.42 -92.96, 20.32 298.14, 1.79 -72.8, -17.41 in-out in 8.9053 Saltbr-out 4.4972 HRD-in -74.85, -51.79 76.63, 2.28 out-in-in SNCoii in-in ActLoopNT-in 2.8295 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.55, 160.28 APE9-dihe-na 116.12, -172.15 APE8-dihe-in -92.31, 127.42 APE8-rot-in 312.53 APE67-dihe-in -58.12, -32.21 -55.48, -45.17 APE12-dist-in 11.3772 APE11-dist-in 12.1036 APE10-dist-in 6.2531 APE9-dist-in 3.7924 Q207D None None XRAY 1.71 0.211 0.253 B 301.0 284.0 11 32 25 7 [[207, 497]] 1.0 5s82 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S86B Q04771 205 499 509.0 LU8:501,XK7:505 Type1,Allosteric Inactive DFGin 6.9997 13.343 BLAminus -124.78, 165.07 76.1, 88.35 -101.51, 22.18 301.71, 177.78 -69.78, -18.41 in-out in 8.8877 Saltbr-out 4.7455 HRD-in -81.45, -50.76 76.49, -0.86 out-in-in SNCoii in-in ActLoopNT-in 2.9308 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.0, 158.9 APE9-dihe-na 111.5, 158.23 APE8-dihe-in -70.2, 127.65 APE8-rot-in 298.18 APE67-dihe-in -59.26, -28.16 -59.39, -41.48 APE12-dist-in 11.6278 APE11-dist-in 12.2182 APE10-dist-in 6.6711 APE9-dist-in 3.6866 Q207D None None XRAY 1.31 0.169 0.19 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s86 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S87B Q04771 205 499 509.0 LU8:501,XKD:505 Type1,Allosteric Inactive DFGin 6.9646 13.3873 BLAminus -125.7, 164.87 74.71, 88.13 -101.5, 22.91 303.75, 177.62 -68.86, -17.71 in-out in 8.8328 Saltbr-out 4.7493 HRD-in -82.36, -52.31 79.91, -1.72 out-in-out SNCoio in-out ActLoopNT-in 2.92 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.25, 165.32 APE9-dihe-na -62.4, 164.8 APE8-dihe-in -61.06, 127.57 APE8-rot-in 297.97 APE67-dihe-in -58.73, -29.86 -59.37, -42.06 APE12-dist-in 10.2433 APE11-dist-out 6.1731 APE10-dist-out 8.9694 APE9-dist-in 3.6795 Q207D None None XRAY 1.3 0.161 0.181 B 301.0 290.0 5 32 32 0 [[207, 497]] 1.0 5s87 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S88B Q04771 205 499 509.0 LU8:501,XKS:505 Type1,Allosteric Inactive DFGin 6.9732 13.376 BLAminus -122.04, 163.88 74.1, 88.2 -100.76, 18.77 302.29, 178.38 -66.87, -16.44 in-out in 8.8711 Saltbr-out 4.7216 HRD-in -80.9, -52.59 78.53, -3.8 out-in-out SNCoio in-out ActLoopNT-in 2.94 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.43, 164.81 APE9-dihe-na -62.32, 166.78 APE8-dihe-in -60.75, 128.44 APE8-rot-in 298.57 APE67-dihe-in -57.52, -28.98 -62.58, -40.65 APE12-dist-in 10.3296 APE11-dist-out 6.1488 APE10-dist-out 9.0268 APE9-dist-in 3.7076 Q207D None None XRAY 1.31 0.16 0.179 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s88 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S8AB Q04771 205 499 509.0 LU8:501,XKY:505 Type1,Allosteric Inactive DFGin 6.9551 13.3366 BLAminus -125.42, 163.04 76.47, 86.69 -100.25, 21.43 305.15, 178.88 -67.55, -16.71 in-out in 8.827 Saltbr-out 4.6784 HRD-in -78.68, -54.41 80.9, -2.81 out-in-out SNCoio in-out ActLoopNT-in 2.9379 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.78, 163.73 APE9-dihe-na -58.28, 164.12 APE8-dihe-in -61.01, 126.61 APE8-rot-in 297.82 APE67-dihe-in -58.41, -30.66 -59.54, -41.22 APE12-dist-in 10.2403 APE11-dist-out 6.1169 APE10-dist-out 9.04 APE9-dist-in 3.7761 Q207D None None XRAY 1.3 0.158 0.179 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s8a Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S75B Q04771 205 499 509.0 LU8:501,HUH:505,HUH:506 Type1,Allosteric,Allosteric Inactive DFGin 7.0427 13.384 BLAminus -125.56, 161.73 76.89, 90.9 -104.0, 22.37 302.45, 178.35 -68.36, -16.58 in-out in 8.8028 Saltbr-out 4.754 HRD-in -77.19, -54.35 79.9, -2.77 out-in-out SNCoio in-out ActLoopNT-in 2.9254 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.92, 165.96 APE9-dihe-na -62.98, 165.92 APE8-dihe-in -61.22, 127.2 APE8-rot-in 298.98 APE67-dihe-in -59.47, -28.54 -61.97, -40.32 APE12-dist-in 10.3728 APE11-dist-out 6.1931 APE10-dist-out 8.992 APE9-dist-in 3.7784 Q207D None None XRAY 1.3 0.156 0.173 B 301.0 293.0 2 32 32 0 [[207, 497]] 1.0 5s75 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S79A Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.3593 13.3075 BLAminus -117.94, 162.46 74.88, 92.31 -102.33, 24.3 297.49, 0.79 -68.18, -20.94 in-out in 9.0932 Saltbr-out 5.8521 HRD-in -74.67, -52.38 75.13, 0.8 out-in-out SNCoio in-out ActLoopNT-in 2.9226 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -130.7, 172.52 APE9-dihe-na -62.7, 161.48 APE8-dihe-in -63.27, 127.15 APE8-rot-in 306.54 APE67-dihe-in -57.17, -31.15 -61.23, -39.7 APE12-dist-none 999.0 APE11-dist-out 6.3758 APE10-dist-out 8.7554 APE9-dist-in 3.742 Q207D None None XRAY 1.5 0.18 0.206 A 301.0 284.0 14 32 20 12 [[207, 497]] 1.0 5s79 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7AB Q04771 205 499 509.0 LU8:501,T5V:505,T5V:506 Type1,Allosteric,Allosteric Inactive DFGin 7.0387 13.38 BLAminus -126.41, 163.07 76.94, 87.35 -100.8, 22.69 302.52, 175.53 -70.21, -15.13 in-out in 8.793 Saltbr-out 4.7212 HRD-in -77.59, -56.91 81.94, -2.79 out-in-out SNCoio in-out ActLoopNT-in 2.9306 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.27, 167.32 APE9-dihe-na -61.57, 164.52 APE8-dihe-in -61.32, 127.79 APE8-rot-in 299.15 APE67-dihe-in -59.77, -26.87 -62.23, -39.78 APE12-dist-in 10.3297 APE11-dist-out 6.2327 APE10-dist-out 8.9798 APE9-dist-in 3.8335 Q207D None None XRAY 1.3 0.16 0.18 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7a Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7EA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509 Type1,Allosteric,Allosteric Inactive DFGin 8.3788 13.303 BLAminus -121.44, 162.36 74.46, 91.44 -103.29, 27.05 299.26, 176.52 -69.12, -17.65 in-out in 9.1784 Saltbr-out 6.1061 HRD-in -79.8, -52.73 76.32, 0.43 out-in-out SNCoio in-out ActLoopNT-in 2.8856 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.76, 172.59 APE9-dihe-na -57.54, 160.03 APE8-dihe-in -61.32, 126.08 APE8-rot-in 304.6 APE67-dihe-in -53.51, -32.05 -63.31, -40.67 APE12-dist-none 999.0 APE11-dist-out 6.3076 APE10-dist-out 8.8411 APE9-dist-in 3.7139 Q207D None None XRAY 1.32 0.168 0.189 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s7e Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7FA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509 Type1,Allosteric,Allosteric Inactive DFGin 8.3693 13.3205 BLAminus -122.11, 160.49 78.65, 89.18 -101.96, 26.72 301.12, 175.97 -69.09, -20.41 in-out in 9.1008 Saltbr-out 6.107 HRD-in -78.16, -52.77 77.11, -0.2 out-in-out SNCoio in-out ActLoopNT-in 2.9175 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.41, 172.12 APE9-dihe-na -64.48, 163.27 APE8-dihe-in -60.82, 122.78 APE8-rot-in 304.26 APE67-dihe-in -57.8, -32.72 -63.43, -34.75 APE12-dist-none 999.0 APE11-dist-out 6.2328 APE10-dist-out 8.8508 APE9-dist-in 3.6754 Q207D None None XRAY 1.31 0.151 0.169 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s7f Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7FB Q04771 205 499 509.0 LU8:501,XH4:505,XH4:506 Type1,Allosteric,Allosteric Inactive DFGin 7.0038 13.3859 BLAminus -125.15, 160.98 75.58, 90.9 -103.26, 20.62 302.27, 174.02 -66.35, -18.49 in-out in 8.851 Saltbr-out 4.7675 HRD-in -78.67, -52.91 79.11, -3.95 out-in-out SNCoio in-out ActLoopNT-in 2.9186 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.71, 164.43 APE9-dihe-na -63.66, 165.2 APE8-dihe-in -60.32, 128.18 APE8-rot-in 298.19 APE67-dihe-in -60.19, -25.76 -61.92, -39.78 APE12-dist-in 10.3447 APE11-dist-out 6.1141 APE10-dist-out 9.0418 APE9-dist-in 3.8278 Q207D None None XRAY 1.31 0.151 0.169 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7f Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7GA Q04771 202 498 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.4994 13.3287 BLAminus -125.16, 165.77 74.59, 86.92 -99.45, 20.56 296.92, 176.9 -55.21, -25.24 in-out in 9.3288 Saltbr-out 5.7883 HRD-in -78.53, -53.51 74.34, 2.0 out-in-none SNCoin in-none ActLoopNT-in 2.9022 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -116.42, 161.19 APE9-dihe-na 107.2, -168.38 APE8-dihe-in -91.58, 123.63 APE8-rot-in 309.25 APE67-dihe-in -59.99, -30.06 -55.11, -41.51 APE12-dist-none 999.0 APE11-dist-in 10.3661 APE10-dist-in 6.4234 APE9-dist-in 3.9062 Q207D None None XRAY 1.78 0.206 0.252 A 301.0 284.0 13 32 19 13 [[207, 497]] 1.0 5s7g Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7OA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.2912 13.4214 BLAminus -118.75, 163.36 74.89, 87.72 -99.53, 25.84 300.09, 2.07 -68.13, -17.89 in-out in 9.2067 Saltbr-out 6.1972 HRD-in -76.07, -55.9 78.85, -1.81 out-in-out SNCoio in-out ActLoopNT-in 2.9138 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.0, 170.72 APE9-dihe-na -63.29, 163.84 APE8-dihe-in -60.21, 123.9 APE8-rot-in 304.44 APE67-dihe-in -59.71, -29.26 -62.37, -36.73 APE12-dist-in 11.0381 APE11-dist-out 6.0384 APE10-dist-out 8.8683 APE9-dist-in 3.6435 Q207D None None XRAY 1.43 0.165 0.189 A 301.0 287.0 12 32 21 11 [[207, 497]] 1.0 5s7o Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7QA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.3905 13.1124 BLAminus -122.32, 165.01 69.61, 90.09 -98.74, 20.54 300.47, 4.84 -55.87, -28.73 in-out in 9.1154 Saltbr-out 6.1758 HRD-in -80.49, -54.34 80.36, -1.4 out-in-out SNCoio in-out ActLoopNT-in 2.9335 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.26, 178.66 APE9-dihe-na -63.48, 166.31 APE8-dihe-in -61.68, 126.19 APE8-rot-in 310.31 APE67-dihe-in -52.14, -34.66 -61.41, -42.72 APE12-dist-none 999.0 APE11-dist-out 6.7892 APE10-dist-out 8.8904 APE9-dist-in 3.5385 Q207D None None XRAY 1.53 0.209 0.243 A 301.0 282.0 16 32 19 13 [[207, 497]] 1.0 5s7q Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7UA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.3051 13.2129 BLAminus -114.05, 162.83 73.86, 86.44 -96.11, 24.11 301.91, 5.0 -63.32, -18.47 in-out in 9.2232 Saltbr-out 5.6693 HRD-in -78.6, -56.95 81.06, 1.88 out-in-none SNCoin in-none ActLoopNT-in 2.8879 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -102.37, -33.42 APE9-dihe-na -82.13, -169.33 APE8-dihe-in -70.61, 128.02 APE8-rot-in 308.81 APE67-dihe-in -53.65, -30.76 -61.02, -43.28 APE12-dist-none 999.0 APE11-dist-in 10.9037 APE10-dist-in 6.4566 APE9-dist-in 3.6543 Q207D None None XRAY 1.59 0.219 0.261 A 301.0 280.0 18 32 19 13 [[207, 497]] 1.0 5s7u Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7UB Q04771 205 499 509.0 LU8:501,XGY:505,XGY:506 Type1,Allosteric,Allosteric Inactive DFGin 6.6967 13.3542 BLAminus -130.21, 164.61 74.6, 82.7 -94.38, 13.73 305.4, 176.35 -55.24, -22.33 in-out in 8.956 Saltbr-out 4.6866 HRD-in -75.48, -53.06 77.34, -3.38 out-in-out SNCoio in-out ActLoopNT-in 2.8147 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -164.99, 129.38 APE9-dihe-na -126.69, -126.94 APE8-dihe-in -91.63, 124.43 APE8-rot-in 299.73 APE67-dihe-in -58.25, -31.07 -56.39, -48.22 APE12-dist-in 10.8295 APE11-dist-in 11.4695 APE10-dist-out 9.5141 APE9-dist-in 4.0299 Q207D None None XRAY 1.59 0.219 0.261 B 301.0 279.0 16 32 23 9 [[207, 497]] 1.0 5s7u Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7VA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.3286 13.327 BLAminus -124.73, 163.23 77.04, 90.62 -101.21, 26.19 302.83, 177.61 -67.83, -17.56 in-out in 9.1318 Saltbr-out 5.9192 HRD-in -78.43, -52.77 77.91, -0.2 out-in-out SNCoio in-out ActLoopNT-in 2.9305 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.42, 168.77 APE9-dihe-na -60.41, 164.86 APE8-dihe-in -63.38, 124.43 APE8-rot-in 302.99 APE67-dihe-in -57.33, -32.29 -63.57, -36.66 APE12-dist-none 999.0 APE11-dist-out 6.1362 APE10-dist-out 8.8767 APE9-dist-in 3.6862 Q207D None None XRAY 1.31 0.154 0.172 A 301.0 282.0 16 32 20 12 [[207, 497]] 1.0 5s7v Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7WA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.3816 13.4221 BLAminus -120.63, 163.92 74.5, 89.95 -100.48, 28.03 301.03, 179.86 -70.31, -18.41 in-out in 9.2435 Saltbr-out 6.2008 HRD-in -78.77, -52.99 79.89, -3.2 out-in-out SNCoio in-out ActLoopNT-in 2.9396 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.35, 170.12 APE9-dihe-na -61.34, 168.74 APE8-dihe-in -65.88, 124.22 APE8-rot-in 304.99 APE67-dihe-in -56.25, -29.94 -63.21, -38.79 APE12-dist-none 999.0 APE11-dist-out 6.2527 APE10-dist-out 8.9271 APE9-dist-in 3.6958 Q207D None None XRAY 1.33 0.164 0.186 A 301.0 284.0 14 32 19 13 [[207, 497]] 1.0 5s7w Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7YA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.3776 13.3431 BLAminus -121.01, 162.15 74.22, 90.85 -101.18, 24.99 303.51, 176.94 -65.0, -19.5 in-out in 9.2462 Saltbr-out 6.2055 HRD-in -79.92, -53.25 77.89, -1.46 out-in-out SNCoio in-out ActLoopNT-in 2.9029 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -125.05, 171.62 APE9-dihe-na -63.16, 165.02 APE8-dihe-in -61.65, 124.26 APE8-rot-in 302.58 APE67-dihe-in -56.65, -33.92 -63.4, -36.98 APE12-dist-none 999.0 APE11-dist-out 6.068 APE10-dist-out 8.8721 APE9-dist-in 3.6119 Q207D None None XRAY 1.37 0.161 0.184 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s7y Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S80A Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509 Type1,Allosteric,Allosteric Inactive DFGin 8.3137 13.3058 BLAminus -112.55, 159.81 78.34, 88.26 -99.06, 22.42 300.25, 0.46 -63.75, -19.98 in-out in 9.0251 Saltbr-out 5.8825 HRD-in -76.34, -54.31 74.73, 2.06 out-in-out SNCoio in-out ActLoopNT-in 2.9057 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -128.9, 168.55 APE9-dihe-na -54.89, 157.92 APE8-dihe-in -57.52, 122.86 APE8-rot-in 308.47 APE67-dihe-in -52.78, -30.68 -62.36, -41.16 APE12-dist-none 999.0 APE11-dist-out 6.1425 APE10-dist-out 8.7825 APE9-dist-in 3.7345 Q207D None None XRAY 1.67 0.197 0.231 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s80 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S80B Q04771 205 499 509.0 LU8:501,XGM:505,XGM:506 Type1,Allosteric,Allosteric Inactive DFGin 7.0267 13.5533 BLAminus -130.83, 163.29 75.8, 86.12 -98.93, 18.93 301.48, 172.59 -65.51, -18.83 in-out in 8.9692 Saltbr-out 4.718 HRD-in -78.19, -55.2 81.16, -3.45 out-in-out SNCoio in-out ActLoopNT-in 2.8547 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.24, 160.71 APE9-dihe-na -59.43, 165.2 APE8-dihe-in -58.98, 127.47 APE8-rot-in 308.35 APE67-dihe-in -58.04, -28.7 -56.74, -44.6 APE12-dist-in 10.4101 APE11-dist-out 6.1264 APE10-dist-out 9.0862 APE9-dist-in 3.8114 Q207D None None XRAY 1.67 0.197 0.231 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s80 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S82A Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.468 13.2543 BLAminus -122.58, 165.4 75.09, 85.58 -98.64, 22.96 294.39, 0.35 -56.95, -25.74 in-out in 9.3363 Saltbr-out 5.524 HRD-in -76.5, -58.03 77.63, 6.82 out-in-none SNCoin in-none ActLoopNT-in 2.8593 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -106.37, 156.71 APE9-dihe-na 110.11, -167.89 APE8-dihe-in -91.26, 123.24 APE8-rot-in 309.79 APE67-dihe-in -54.4, -31.68 -54.65, -45.23 APE12-dist-none 999.0 APE11-dist-in 10.8938 APE10-dist-in 6.4362 APE9-dist-in 3.9819 Q207D None None XRAY 1.71 0.211 0.253 A 301.0 279.0 19 32 19 13 [[207, 497]] 1.0 5s82 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S87A Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.356 13.334 BLAminus -124.64, 162.22 77.24, 89.92 -101.8, 26.16 301.34, 177.73 -70.64, -14.84 in-out in 9.288 Saltbr-out 6.0745 HRD-in -77.97, -54.71 79.68, 0.35 out-in-out SNCoio in-out ActLoopNT-in 2.9318 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.28, 171.55 APE9-dihe-na -60.97, 165.72 APE8-dihe-in -65.13, 123.33 APE8-rot-in 301.16 APE67-dihe-in -56.7, -32.97 -59.78, -39.02 APE12-dist-none 999.0 APE11-dist-out 6.2457 APE10-dist-out 9.0747 APE9-dist-in 3.5643 Q207D None None XRAY 1.3 0.161 0.181 A 301.0 284.0 15 32 19 13 [[207, 497]] 1.0 5s87 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S88A Q04771 202 499 509.0 LU8:501,LU8:506,LU8:507 Type1,Allosteric,Allosteric Inactive DFGin 8.3908 13.328 BLAminus -125.32, 162.15 75.36, 89.99 -102.31, 27.55 301.87, 179.45 -66.0, -20.71 in-out in 9.2871 Saltbr-out 6.0568 HRD-in -78.45, -54.06 78.95, -0.59 out-in-out SNCoio in-out ActLoopNT-in 2.9384 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.53, 173.56 APE9-dihe-na -66.93, 166.27 APE8-dihe-in -60.51, 123.12 APE8-rot-in 301.13 APE67-dihe-in -58.29, -28.73 -59.87, -40.21 APE12-dist-none 999.0 APE11-dist-out 6.1893 APE10-dist-out 8.9793 APE9-dist-in 3.5981 Q207D None None XRAY 1.31 0.16 0.179 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s88 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S9KA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508 Type1,Allosteric,Allosteric Inactive DFGin 8.3518 13.3497 BLAminus -119.09, 162.43 73.95, 91.92 -101.37, 24.48 300.38, 179.39 -71.09, -13.1 in-out in 9.3128 Saltbr-out 6.1587 HRD-in -79.72, -52.91 78.84, -1.65 out-in-out SNCoio in-out ActLoopNT-in 2.9269 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -122.92, 173.99 APE9-dihe-na -63.97, 163.84 APE8-dihe-in -62.03, 121.91 APE8-rot-in 301.87 APE67-dihe-in -54.23, -35.11 -55.21, -43.69 APE12-dist-none 999.0 APE11-dist-out 6.3795 APE10-dist-out 9.1471 APE9-dist-in 3.5222 Q207D None None XRAY 1.35 0.176 0.2 A 301.0 281.0 18 32 19 13 [[207, 497]] 1.0 5s9k Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6SRHB Q04771 205 499 509.0 LU8:501,LU8:502,LU8:503 Type1,Allosteric,Allosteric Inactive DFGin 6.9365 13.3915 BLAminus -126.84, 164.05 75.03, 87.93 -100.83, 18.93 301.99, 177.59 -71.89, -11.94 in-out in 8.9116 Saltbr-out 4.7467 HRD-in -80.94, -52.46 80.13, -0.8 out-in-out SNCoio in-out ActLoopNT-in 2.9248 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.66, 165.78 APE9-dihe-na -63.94, 166.94 APE8-dihe-in -62.11, 128.55 APE8-rot-in 298.15 APE67-dihe-in -60.05, -27.13 -57.77, -43.71 APE12-dist-in 10.3292 APE11-dist-out 6.1224 APE10-dist-out 9.0702 APE9-dist-in 3.8077 Q207D None None XRAY 1.25 0.134 0.16 B 301.0 295.0 0 32 32 0 [[207, 497]] 1.0 6srh Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S77A Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,BAQ:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3912 13.2913 BLAminus -123.97, 162.56 76.16, 90.86 -104.32, 25.92 302.2, 176.49 -70.33, -17.0 in-out in 9.1926 Saltbr-out 6.1664 HRD-in -75.36, -54.06 76.91, 1.59 out-in-out SNCoio in-out ActLoopNT-in 2.9281 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.85, 171.29 APE9-dihe-na -63.22, 166.14 APE8-dihe-in -65.07, 121.84 APE8-rot-in 300.34 APE67-dihe-in -56.11, -31.98 -61.83, -38.01 APE12-dist-none 999.0 APE11-dist-out 6.3001 APE10-dist-out 8.8524 APE9-dist-in 3.638 Q207D None None XRAY 1.31 0.166 0.185 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s77 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7DA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,XHD:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.386 13.3906 BLAminus -121.08, 159.87 78.87, 90.19 -102.41, 28.04 302.41, 178.35 -70.75, -16.32 in-out in 9.2242 Saltbr-out 6.1349 HRD-in -78.63, -52.52 79.29, -0.45 out-in-out SNCoio in-out ActLoopNT-in 2.9565 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -121.09, 171.05 APE9-dihe-na -61.33, 164.08 APE8-dihe-in -64.43, 124.8 APE8-rot-in 301.32 APE67-dihe-in -57.7, -30.13 -64.02, -36.73 APE12-dist-none 999.0 APE11-dist-out 6.2255 APE10-dist-out 8.8952 APE9-dist-in 3.7101 Q207D None None XRAY 1.31 0.165 0.185 A 301.0 284.0 14 32 20 12 [[207, 497]] 1.0 5s7d Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7JA Q04771 201 499 509.0 LU8:501,LU8:506,LU8:507,XHG:508 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3538 13.4667 BLAminus -120.47, 161.42 75.57, 90.44 -100.52, 24.64 297.99, 178.42 -66.79, -16.07 in-out in 9.1183 Saltbr-out 6.1093 HRD-in -76.74, -56.59 80.01, 1.36 out-in-out SNCoio in-out ActLoopNT-in 2.8973 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.11, 169.97 APE9-dihe-na -61.08, 166.56 APE8-dihe-in -64.82, 124.61 APE8-rot-in 302.51 APE67-dihe-in -56.89, -31.73 -63.18, -39.12 APE12-dist-in 10.4402 APE11-dist-out 6.0435 APE10-dist-out 8.8554 APE9-dist-in 3.7007 Q207D None None XRAY 1.31 0.159 0.181 A 301.0 286.0 13 32 21 11 [[207, 497]] 1.0 5s7j Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7KA Q04771 202 499 509.0 LU8:501,LU8:506,LU8:507,XEJ:508 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3571 13.2978 BLAminus -121.51, 161.1 74.44, 89.19 -99.73, 25.08 301.6, 0.3 -69.43, -16.12 in-out in 9.3172 Saltbr-out 6.0158 HRD-in -77.56, -55.15 80.71, -0.51 out-in-none SNCoin in-none ActLoopNT-in 2.9289 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -93.42, -15.71 APE9-dihe-na -77.62, 169.4 APE8-dihe-in -59.03, 123.75 APE8-rot-in 304.14 APE67-dihe-in -58.63, -30.05 -60.7, -39.73 APE12-dist-none 999.0 APE11-dist-in 11.7963 APE10-dist-in 6.0089 APE9-dist-in 3.542 None None None XRAY 1.31 0.162 0.188 A 301.0 285.0 13 32 21 11 [[207, 497]] 1.0 5s7k Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7LA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,XHJ:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3207 13.3339 BLAminus -121.54, 163.42 75.33, 89.93 -101.4, 25.91 299.12, 0.16 -70.86, -16.31 in-out in 9.0177 Saltbr-out 5.8431 HRD-in -77.38, -52.76 78.01, -1.55 out-in-out SNCoio in-out ActLoopNT-in 2.8952 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -125.9, 174.3 APE9-dihe-na -64.5, 161.75 APE8-dihe-in -61.28, 122.78 APE8-rot-in 301.43 APE67-dihe-in -55.46, -32.76 -59.71, -41.51 APE12-dist-in 10.728 APE11-dist-out 6.281 APE10-dist-out 8.7835 APE9-dist-in 3.7348 Q207D None None XRAY 1.36 0.167 0.188 A 301.0 286.0 13 32 21 11 [[207, 497]] 1.0 5s7l Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7MA Q04771 202 499 509.0 LU8:501,LU8:507,HVK:508,HVK:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.2948 13.3693 BLAminus -125.86, 158.69 77.31, 90.22 -102.58, 22.57 301.89, 179.15 -62.4, -27.33 in-out in 9.2746 Saltbr-out 6.0388 HRD-in -76.09, -53.81 76.66, 2.88 out-in-out SNCoio in-out ActLoopNT-in 2.9008 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -128.0, 172.86 APE9-dihe-na -61.78, 157.6 APE8-dihe-in -61.33, 123.11 APE8-rot-in 304.71 APE67-dihe-in -54.75, -34.14 -63.89, -37.36 APE12-dist-in 11.0098 APE11-dist-out 6.3161 APE10-dist-out 8.7728 APE9-dist-in 3.828 Q207D None None XRAY 1.32 0.171 0.195 A 301.0 285.0 13 32 22 10 [[207, 497]] 1.0 5s7m Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7NA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,2AI:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3692 13.3273 BLAminus -120.76, 160.23 77.83, 89.81 -101.82, 25.77 300.77, 176.65 -67.07, -19.31 in-out in 9.1914 Saltbr-out 6.1991 HRD-in -78.31, -53.54 78.72, -0.87 out-in-out SNCoio in-out ActLoopNT-in 2.9272 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -111.12, 164.18 APE9-dihe-na -67.39, 173.07 APE8-dihe-in -61.91, 122.38 APE8-rot-in 303.15 APE67-dihe-in -57.78, -31.63 -60.2, -38.53 APE12-dist-none 999.0 APE11-dist-out 7.8661 APE10-dist-out 9.1731 APE9-dist-in 3.6452 Q207D None None XRAY 1.3 0.163 0.186 A 301.0 286.0 13 32 19 13 [[207, 497]] 1.0 5s7n Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7PA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,V1L:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3631 13.3516 BLAminus -121.35, 161.97 76.5, 90.18 -103.45, 27.08 300.94, 178.65 -69.09, -20.15 in-out in 9.1735 Saltbr-out 6.1815 HRD-in -76.2, -55.65 77.56, 1.63 out-in-out SNCoio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.42, 170.99 APE9-dihe-na -65.1, 166.64 APE8-dihe-in -64.52, 122.28 APE8-rot-in 301.0 APE67-dihe-in -57.28, -33.44 -60.97, -37.49 APE12-dist-none 999.0 APE11-dist-out 6.3362 APE10-dist-out 8.8101 APE9-dist-in 3.6483 Q207D None None XRAY 1.31 0.158 0.176 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s7p Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7SA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,09V:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3742 13.2602 BLAminus -125.11, 163.99 74.48, 91.32 -103.07, 26.34 302.08, 178.93 -70.93, -18.68 in-out in 9.1341 Saltbr-out 5.9366 HRD-in -77.09, -53.7 75.14, 2.55 out-in-out SNCoio in-out ActLoopNT-in 2.9167 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.89, 171.8 APE9-dihe-na -59.35, 163.03 APE8-dihe-in -63.02, 122.62 APE8-rot-in 301.85 APE67-dihe-in -55.53, -31.77 -61.45, -39.86 APE12-dist-in 10.5844 APE11-dist-out 6.3931 APE10-dist-out 8.796 APE9-dist-in 3.663 Q207D None None XRAY 1.3 0.153 0.171 A 301.0 287.0 11 32 23 9 [[207, 497]] 1.0 5s7s Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7TB Q04771 205 498 509.0 LU8:501,XGJ:505,XGJ:506,XGJ:507 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 7.3485 13.3837 BLAminus -130.84, 165.78 74.23, 86.23 -101.88, 22.54 301.68, 171.79 -65.62, -21.79 in-out in 8.8425 Saltbr-out 4.3703 HRD-in -75.87, -54.78 79.04, -1.82 out-in-out SNCoio in-out ActLoopNT-in 2.9373 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -106.86, 165.74 APE9-dihe-na -60.63, 163.96 APE8-dihe-in -61.22, 126.89 APE8-rot-in 299.34 APE67-dihe-in -62.98, -26.85 -63.53, -36.43 APE12-dist-in 10.5242 APE11-dist-out 6.9677 APE10-dist-out 9.1121 APE9-dist-in 3.8863 Q207D None None XRAY 1.3 0.155 0.174 B 301.0 294.0 0 32 32 0 [[207, 497]] 1.0 5s7t Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7XA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,LGA:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.365 13.3392 BLAminus -120.33, 161.6 75.96, 90.47 -101.36, 24.64 300.81, 178.23 -69.2, -15.97 in-out in 9.1534 Saltbr-out 6.1306 HRD-in -77.36, -53.88 76.8, 3.92 out-in-out SNCoio in-out ActLoopNT-in 2.9429 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.06, 170.39 APE9-dihe-na -62.49, 167.4 APE8-dihe-in -64.84, 124.15 APE8-rot-in 301.78 APE67-dihe-in -56.96, -32.72 -62.72, -36.99 APE12-dist-none 999.0 APE11-dist-out 6.2275 APE10-dist-out 8.8288 APE9-dist-in 3.6624 Q207D None None XRAY 1.3 0.151 0.169 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s7x Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S86A Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,XK7:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3538 13.3046 BLAminus -123.41, 163.19 74.35, 90.8 -102.12, 25.57 300.77, 178.94 -68.55, -18.48 in-out in 9.3264 Saltbr-out 6.0597 HRD-in -80.27, -53.89 78.04, 1.57 out-in-out SNCoio in-out ActLoopNT-in 2.9287 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.39, 173.24 APE9-dihe-na -67.68, 166.72 APE8-dihe-in -62.8, 124.74 APE8-rot-in 300.74 APE67-dihe-in -57.85, -29.86 -60.17, -41.27 APE12-dist-none 999.0 APE11-dist-out 6.4584 APE10-dist-out 9.1419 APE9-dist-in 3.5121 Q207D None None XRAY 1.31 0.169 0.19 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s86 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S89A Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,XKV:509 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3474 13.3769 BLAminus -121.17, 161.16 76.55, 91.35 -102.29, 27.94 301.32, 178.72 -70.17, -17.75 in-out in 9.3272 Saltbr-out 6.1807 HRD-in -77.92, -53.6 79.17, 0.85 out-in-out SNCoio in-out ActLoopNT-in 2.9289 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -120.5, 170.79 APE9-dihe-na -62.09, 168.52 APE8-dihe-in -64.51, 125.09 APE8-rot-in 300.94 APE67-dihe-in -58.18, -30.47 -62.43, -38.68 APE12-dist-none 999.0 APE11-dist-out 6.222 APE10-dist-out 9.1355 APE9-dist-in 3.6114 Q207D None None XRAY 1.3 0.156 0.174 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s89 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S8AA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,XKY:510 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3751 13.2912 BLAminus -123.48, 162.27 75.26, 91.11 -103.25, 28.11 302.42, 0.24 -70.28, -18.37 in-out in 9.2906 Saltbr-out 6.0868 HRD-in -77.3, -55.71 79.01, -0.21 out-in-out SNCoio in-out ActLoopNT-in 2.9308 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.8, 171.85 APE9-dihe-na -62.19, 164.47 APE8-dihe-in -62.15, 125.78 APE8-rot-in 303.5 APE67-dihe-in -57.64, -30.13 -63.86, -37.62 APE12-dist-none 999.0 APE11-dist-out 6.2268 APE10-dist-out 8.8929 APE9-dist-in 3.6826 Q207D None None XRAY 1.3 0.158 0.179 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s8a Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S8BB Q04771 205 499 509.0 LU8:501,XFV:505,XFV:506,XFV:507 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 6.8865 13.2682 BLAminus -123.76, 160.92 77.33, 89.17 -99.67, 18.5 303.55, 1.64 -66.62, -18.66 in-out in 8.6237 Saltbr-out 4.5819 HRD-in -80.97, -53.82 77.81, 1.71 out-in-out SNCoio in-out ActLoopNT-in 2.8434 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.23, 169.28 APE9-dihe-na -63.35, 164.6 APE8-dihe-in -57.58, 127.02 APE8-rot-in 306.31 APE67-dihe-in -56.16, -27.82 -54.33, -48.01 APE12-dist-in 10.2869 APE11-dist-out 6.129 APE10-dist-out 8.9433 APE9-dist-in 3.7756 Q207D None None XRAY 1.64 0.2 0.233 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s8b Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S75A Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,HUH:510,HUH:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.4122 13.3109 BLAminus -121.86, 161.2 77.57, 90.63 -103.17, 26.39 302.13, 178.97 -70.27, -17.43 in-out in 9.1959 Saltbr-out 6.1065 HRD-in -77.34, -53.49 77.65, 2.76 out-in-out SNCoio in-out ActLoopNT-in 2.9431 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.16, 170.77 APE9-dihe-na -65.21, 166.76 APE8-dihe-in -64.6, 123.77 APE8-rot-in 302.54 APE67-dihe-in -59.09, -30.5 -61.28, -37.14 APE12-dist-none 999.0 APE11-dist-out 6.2204 APE10-dist-out 8.9132 APE9-dist-in 3.6893 Q207D None None XRAY 1.3 0.156 0.173 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s75 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7AA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,T5V:509,T5V:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.342 13.3138 BLAminus -121.52, 160.72 75.85, 90.49 -101.87, 26.96 302.71, 179.1 -70.78, -16.97 in-out in 9.1949 Saltbr-out 6.1794 HRD-in -77.37, -53.71 77.98, -0.37 out-in-out SNCoio in-out ActLoopNT-in 2.9196 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -125.86, 170.85 APE9-dihe-na -58.96, 161.85 APE8-dihe-in -63.33, 122.4 APE8-rot-in 301.84 APE67-dihe-in -56.7, -33.07 -63.45, -35.84 APE12-dist-none 999.0 APE11-dist-out 6.3662 APE10-dist-out 8.8519 APE9-dist-in 3.6683 Q207D None None XRAY 1.3 0.16 0.18 A 301.0 285.0 14 32 20 12 [[207, 497]] 1.0 5s7a Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7BA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,XH7:509,XH7:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.4061 13.3525 BLAminus -122.54, 161.25 77.75, 89.14 -102.53, 25.49 298.26, 177.49 -68.5, -17.41 in-out in 9.1558 Saltbr-out 5.9622 HRD-in -75.98, -54.72 78.12, -0.13 out-in-out SNCoio in-out ActLoopNT-in 2.9081 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -121.74, 156.48 APE9-dihe-na -76.58, -177.16 APE8-dihe-in -62.22, 124.84 APE8-rot-in 304.94 APE67-dihe-in -57.93, -31.87 -59.46, -41.19 APE12-dist-out 5.2863 APE11-dist-in 8.586 APE10-dist-out 9.3111 APE9-dist-in 3.6782 Q207D None None XRAY 1.32 0.169 0.195 A 301.0 285.0 13 32 22 10 [[207, 497]] 1.0 5s7b Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7HA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,HVB:509,HVB:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.4004 13.3492 BLAminus -122.03, 161.2 75.68, 88.77 -99.68, 25.56 301.4, 178.71 -69.41, -15.19 in-out in 9.2841 Saltbr-out 6.1124 HRD-in -74.82, -53.78 79.5, -0.11 out-in-out SNCoio in-out ActLoopNT-in 2.9554 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.66, 158.62 APE9-dihe-na -71.55, -178.8 APE8-dihe-in -67.44, 125.65 APE8-rot-in 300.35 APE67-dihe-in -57.2, -30.23 -61.33, -40.16 APE12-dist-none 999.0 APE11-dist-out 6.4173 APE10-dist-out 9.333 APE9-dist-in 3.6164 Q207D None None XRAY 1.3 0.158 0.18 A 301.0 284.0 15 32 20 12 [[207, 497]] 1.0 5s7h Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7ZA Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,BYZ:510,BYZ:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3715 13.3787 BLAminus -118.29, 164.94 73.01, 90.28 -101.45, 25.18 297.95, 179.49 -66.08, -18.47 in-out in 9.0354 Saltbr-out 5.8164 HRD-in -75.5, -56.61 78.44, 1.56 out-in-out SNCoio in-out ActLoopNT-in 2.884 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.97, 169.25 APE9-dihe-na -61.57, 164.92 APE8-dihe-in -63.28, 125.7 APE8-rot-in 303.7 APE67-dihe-in -57.35, -34.69 -61.46, -39.19 APE12-dist-in 10.5839 APE11-dist-out 6.2834 APE10-dist-out 8.9041 APE9-dist-in 3.732 Q207D None None XRAY 1.3 0.163 0.184 A 301.0 287.0 11 32 23 9 [[207, 497]] 1.0 5s7z Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S81B Q04771 208 499 509.0 LU8:501,XJV:505,XJV:506,XJV:507,XJV:508 Type1,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 7.0985 13.4687 BLAminus -122.8, 162.49 76.01, 87.95 -102.27, 24.4 302.62, 170.08 -70.81, -17.85 in-out in 8.7907 Saltbr-out 4.6119 HRD-in -80.16, -52.27 79.27, -5.04 out-in-out SNCoio in-out ActLoopNT-in 2.9443 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.12, 164.98 APE9-dihe-na -61.51, 162.25 APE8-dihe-in -57.76, 127.22 APE8-rot-in 301.4 APE67-dihe-in -60.84, -27.37 -62.01, -41.07 APE12-dist-in 10.3598 APE11-dist-out 6.1972 APE10-dist-out 8.9898 APE9-dist-in 3.8886 Q207D None None XRAY 1.43 0.17 0.196 B 301.0 289.0 3 32 32 0 [[207, 497]] 1.0 5s81 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7CA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,T5Y:509,T5Y:510,T5Y:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3393 13.3454 BLAminus -122.66, 161.69 76.15, 92.72 -104.11, 24.78 300.15, 178.43 -66.33, -20.88 in-out in 9.2312 Saltbr-out 6.1549 HRD-in -76.23, -54.18 77.19, 0.83 out-in-out SNCoio in-out ActLoopNT-in 2.9506 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.75, 170.87 APE9-dihe-na -60.45, 165.58 APE8-dihe-in -64.98, 123.25 APE8-rot-in 303.45 APE67-dihe-in -56.7, -31.98 -63.36, -36.72 APE12-dist-none 999.0 APE11-dist-out 6.251 APE10-dist-out 8.8085 APE9-dist-in 3.7199 Q207D None None XRAY 1.31 0.161 0.179 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s7c Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7IA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,HV2:509,HV2:510,HV2:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.4231 13.4136 BLAminus -121.19, 161.49 77.75, 90.77 -102.55, 26.67 296.81, 175.99 -70.08, -16.54 in-out in 9.1542 Saltbr-out 6.1975 HRD-in -79.1, -52.38 76.17, 1.2 out-in-out SNCoio in-out ActLoopNT-in 2.8872 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.34, 168.68 APE9-dihe-na -65.41, 166.87 APE8-dihe-in -63.35, 124.96 APE8-rot-in 301.24 APE67-dihe-in -56.97, -30.73 -63.49, -38.5 APE12-dist-none 999.0 APE11-dist-out 6.0485 APE10-dist-out 8.8992 APE9-dist-in 3.6905 Q207D None None XRAY 1.3 0.158 0.176 A 301.0 284.0 15 32 19 13 [[207, 497]] 1.0 5s7i Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7TA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,XGJ:509,XGJ:510,XGJ:511 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3641 13.3581 BLAminus -122.53, 161.24 78.81, 92.17 -103.84, 26.27 299.68, 1.07 -70.27, -17.35 in-out in 9.1872 Saltbr-out 6.1023 HRD-in -73.55, -56.12 78.98, 0.06 out-in-out SNCoio in-out ActLoopNT-in 2.9448 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -126.64, 169.46 APE9-dihe-na -62.74, 163.72 APE8-dihe-in -63.21, 123.01 APE8-rot-in 300.97 APE67-dihe-in -58.38, -31.17 -61.88, -38.7 APE12-dist-none 999.0 APE11-dist-out 6.217 APE10-dist-out 8.8776 APE9-dist-in 3.7084 Q207D None None XRAY 1.3 0.155 0.174 A 301.0 284.0 14 32 20 12 [[207, 497]] 1.0 5s7t Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7YB Q04771 207 499 509.0 LU8:501,XJP:505,XJP:506,XJP:507,XJP:508,XJP:509 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 7.0154 13.4267 BLAminus -126.98, 162.69 75.57, 89.14 -100.94, 21.08 303.3, 173.42 -67.07, -20.24 in-out in 8.8412 Saltbr-out 4.7344 HRD-in -81.6, -53.06 80.61, -4.28 out-in-out SNCoio in-out ActLoopNT-in 2.9288 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.96, 164.75 APE9-dihe-na -61.91, 164.34 APE8-dihe-in -58.26, 128.88 APE8-rot-in 298.27 APE67-dihe-in -57.49, -30.88 -60.34, -41.77 APE12-dist-in 10.3261 APE11-dist-out 6.153 APE10-dist-out 9.0872 APE9-dist-in 3.7656 Q207D None None XRAY 1.37 0.161 0.184 B 301.0 290.0 3 32 32 0 [[207, 497]] 1.0 5s7y Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7RB Q04771 205 499 509.0 LU8:501,XGS:505,XGS:506,XGS:507,XGS:508,XGS:509,XGS:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 6.9508 13.305 BLAminus -123.51, 161.17 75.08, 89.73 -101.63, 18.32 302.56, 179.54 -66.27, -18.2 in-out in 8.7282 Saltbr-out 4.7541 HRD-in -80.45, -51.89 79.75, -1.22 out-in-out SNCoio in-out ActLoopNT-in 2.924 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.67, 165.96 APE9-dihe-na -61.08, 162.39 APE8-dihe-in -58.43, 128.17 APE8-rot-in 299.47 APE67-dihe-in -59.07, -29.26 -60.13, -43.27 APE12-dist-in 10.3121 APE11-dist-out 6.1071 APE10-dist-out 9.0326 APE9-dist-in 3.8788 Q207D None None XRAY 1.46 0.173 0.198 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7r Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S85A Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,XK4:509,XK4:510,XK4:511,XK4:512 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3817 13.3344 BLAminus -122.41, 161.16 77.18, 90.52 -102.57, 24.0 300.65, 177.17 -69.5, -18.6 in-out in 9.1659 Saltbr-out 6.0741 HRD-in -76.19, -53.3 76.63, 0.17 out-in-out SNCoio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -127.51, 169.88 APE9-dihe-na -65.71, 163.81 APE8-dihe-in -61.83, 125.14 APE8-rot-in 302.55 APE67-dihe-in -58.05, -31.45 -63.04, -37.5 APE12-dist-none 999.0 APE11-dist-out 6.228 APE10-dist-out 8.8547 APE9-dist-in 3.7358 Q207D None None XRAY 1.33 0.162 0.182 A 301.0 282.0 16 32 19 13 [[207, 497]] 1.0 5s85 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S8BA Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,XFV:509,XFV:510,XFV:511,XFV:512 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3245 13.2716 BLAminus -118.75, 157.39 80.5, 89.5 -103.48, 23.68 297.02, 5.33 -69.81, -17.79 in-out in 9.013 Saltbr-out 5.9816 HRD-in -76.49, -52.01 73.71, 3.51 out-in-out SNCoio in-out ActLoopNT-in 2.8648 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -132.81, 169.84 APE9-dihe-na -47.57, 153.77 APE8-dihe-in -59.87, 123.35 APE8-rot-in 304.85 APE67-dihe-in -51.72, -35.23 -61.3, -40.47 APE12-dist-none 999.0 APE11-dist-out 6.4138 APE10-dist-out 8.8102 APE9-dist-in 3.6992 Q207D None None XRAY 1.64 0.2 0.233 A 301.0 284.0 15 32 19 13 [[207, 497]] 1.0 5s8b Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7RA Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,XGS:509,XGS:510,XGS:511,XGS:512,XGS:513 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 8.3785 13.2666 BLAminus -118.49, 160.3 77.59, 89.22 -102.83, 29.26 299.84, 3.52 -70.9, -18.65 in-out in 9.1133 Saltbr-out 6.2461 HRD-in -79.07, -53.38 77.46, -1.57 out-in-out SNCoio in-out ActLoopNT-in 2.9231 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -126.05, 166.06 APE9-dihe-na -58.33, 162.52 APE8-dihe-in -61.2, 125.14 APE8-rot-in 304.32 APE67-dihe-in -53.36, -31.96 -64.07, -40.51 APE12-dist-none 999.0 APE11-dist-out 6.0853 APE10-dist-out 8.9465 APE9-dist-in 3.7151 Q207D None None XRAY 1.46 0.173 0.198 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s7r Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7IB Q04771 205 499 509.0 LU8:501,HV2:505,HV2:506,HV2:507,HV2:508,HV2:509,HV2:510,HV2:511,HV2:512,HV2:513 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 7.0297 13.3467 BLAminus -124.03, 163.17 76.81, 90.06 -103.28, 20.27 301.31, 176.76 -69.97, -14.64 in-out in 8.7537 Saltbr-out 4.763 HRD-in -75.19, -55.72 81.55, -2.41 out-in-out SNCoio in-out ActLoopNT-in 2.9502 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.42, 164.49 APE9-dihe-na -59.34, 164.13 APE8-dihe-in -60.56, 130.0 APE8-rot-in 297.57 APE67-dihe-in -61.93, -26.2 -62.79, -39.84 APE12-dist-in 10.3438 APE11-dist-out 6.121 APE10-dist-out 9.0233 APE9-dist-in 3.8528 Q207D None None XRAY 1.3 0.158 0.176 B 301.0 294.0 1 32 32 0 [[207, 497]] 1.0 5s7i Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S78A Q04771 202 499 509.0 LU8:501,LU8:506,LU8:507,XGV:508,XGV:509,XGV:510 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Type1 Inactive DFGin 8.3242 13.3553 BLAminus -121.42, 162.3 75.56, 91.97 -103.54, 25.72 302.81, 1.93 -71.55, -16.97 in-out in 9.2716 Saltbr-out 6.2967 HRD-in -75.89, -55.37 78.61, -0.74 out-in-out SNCoio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -123.0, 170.53 APE9-dihe-na -61.1, 164.91 APE8-dihe-in -65.24, 123.82 APE8-rot-in 300.79 APE67-dihe-in -58.43, -30.55 -62.87, -37.3 APE12-dist-in 9.447 APE11-dist-out 6.1418 APE10-dist-out 8.9017 APE9-dist-in 3.6758 Q207D None None XRAY 1.3 0.16 0.177 A 301.0 285.0 13 32 21 11 [[207, 497]] 1.0 5s78 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S81A Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,XJV:510,XJV:511 Type1,Allosteric,Allosteric,Allosteric,Type1 Inactive DFGin 8.3169 13.2896 BLAminus -119.91, 161.36 74.15, 90.65 -102.16, 24.41 299.52, 0.73 -66.2, -16.75 in-out in 9.161 Saltbr-out 6.2167 HRD-in -73.39, -56.79 82.29, -0.98 out-in-out SNCoio in-out ActLoopNT-in 2.9048 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -125.7, 171.05 APE9-dihe-na -60.67, 164.13 APE8-dihe-in -64.52, 125.11 APE8-rot-in 304.88 APE67-dihe-in -56.55, -33.14 -61.08, -40.13 APE12-dist-none 999.0 APE11-dist-out 6.1891 APE10-dist-out 8.8622 APE9-dist-in 3.6802 Q207D None None XRAY 1.43 0.17 0.196 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s81 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S76A Q04771 202 499 509.0 LU8:501,LU8:507,LU8:508,02A:509,02A:510 Type1,Allosteric,Allosteric,Allosteric,Type1.5_Back Inactive DFGin 8.3968 13.3521 BLAminus -125.71, 163.24 76.56, 90.11 -103.29, 26.3 299.59, 179.12 -70.47, -16.36 in-out in 9.1694 Saltbr-out 6.1364 HRD-in -78.12, -53.94 78.79, 0.3 out-in-out SNCoio in-out ActLoopNT-in 2.9104 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -121.64, 170.51 APE9-dihe-na -62.2, 167.24 APE8-dihe-in -63.35, 123.08 APE8-rot-in 302.24 APE67-dihe-in -58.65, -29.05 -63.37, -35.67 APE12-dist-none 999.0 APE11-dist-out 6.2237 APE10-dist-out 8.9115 APE9-dist-in 3.6733 Q207D None None XRAY 1.31 0.156 0.173 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s76 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7LB Q04771 205 499 509.0 LU8:501,XHJ:505,XHJ:506,XHJ:507,XHJ:508 Type1,Allosteric,Allosteric,Allosteric,Type3 Inactive DFGin 7.1106 13.3904 BLAminus -125.42, 162.47 77.36, 89.52 -102.53, 17.7 300.76, 174.49 -63.63, -17.96 in-out in 8.7862 Saltbr-out 4.4575 HRD-in -76.1, -52.38 79.68, -4.98 out-in-out SNCoio in-out ActLoopNT-in 2.9355 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.61, 167.49 APE9-dihe-na -61.83, 166.04 APE8-dihe-in -62.17, 127.63 APE8-rot-in 299.54 APE67-dihe-in -59.75, -27.49 -60.2, -41.98 APE12-dist-in 10.4367 APE11-dist-out 6.3974 APE10-dist-out 9.019 APE9-dist-in 3.8941 Q207D None None XRAY 1.36 0.167 0.188 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s7l Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S84A Q04771 201 499 509.0 LU8:501,LU8:507,LU8:508,XK1:509 Type1,Allosteric,Allosteric,Type1 Inactive DFGin 8.3364 13.4392 BLAminus -118.42, 161.89 75.73, 89.87 -101.05, 26.48 297.86, 0.33 -68.45, -15.46 in-out in 9.1253 Saltbr-out 6.0801 HRD-in -77.01, -56.17 80.15, -0.22 out-in-out SNCoio in-out ActLoopNT-in 2.8952 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -124.67, 170.99 APE9-dihe-na -62.03, 164.12 APE8-dihe-in -62.23, 123.92 APE8-rot-in 305.79 APE67-dihe-in -60.01, -30.93 -61.35, -38.64 APE12-dist-none 999.0 APE11-dist-out 6.1334 APE10-dist-out 8.8394 APE9-dist-in 3.6798 Q207D None None XRAY 1.35 0.166 0.191 A 301.0 284.0 15 32 19 13 [[207, 497]] 1.0 5s84 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S83A Q04771 202 499 509.0 LU8:501,LU8:508,LU8:509,XJY:510 Type1,Allosteric,Allosteric,Type3 Inactive DFGin 8.4423 13.2233 BLAminus -121.45, 166.08 75.52, 89.79 -103.21, 23.07 300.9, 0.69 -66.79, -19.18 in-out in 8.9661 Saltbr-out 5.6322 HRD-in -77.39, -55.22 76.55, 2.24 out-in-out SNCoio in-out ActLoopNT-in 2.9096 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -123.02, 170.52 APE9-dihe-na -63.69, 168.74 APE8-dihe-in -66.61, 121.49 APE8-rot-in 303.57 APE67-dihe-in -53.26, -35.15 -59.02, -40.84 APE12-dist-none 999.0 APE11-dist-out 6.3416 APE10-dist-out 8.8704 APE9-dist-in 3.7557 Q207D None None XRAY 1.33 0.161 0.185 A 301.0 283.0 15 32 19 13 [[207, 497]] 1.0 5s83 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S7OB Q04771 205 499 509.0 LU8:501,XJJ:505 Type1,Type1 Inactive DFGin 6.984 13.3823 BLAminus -123.75, 162.83 73.51, 87.08 -99.67, 20.63 303.58, 175.53 -70.31, -13.4 in-out in 8.8535 Saltbr-out 4.7545 HRD-in -78.42, -53.12 79.9, -3.76 out-in-out SNCoio in-out ActLoopNT-in 2.9423 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -121.12, 167.38 APE9-dihe-na -65.37, 165.19 APE8-dihe-in -58.94, 129.63 APE8-rot-in 299.85 APE67-dihe-in -59.51, -26.9 -60.64, -42.85 APE12-dist-in 10.3308 APE11-dist-out 6.1918 APE10-dist-out 9.0274 APE9-dist-in 3.8558 Q207D None None XRAY 1.43 0.165 0.189 B 301.0 295.0 0 32 32 0 [[207, 497]] 1.0 5s7o Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S85B Q04771 207 499 509.0 LU8:501,XK4:505,XK4:506,XK4:507 Type1,Type1,Allosteric,Allosteric Inactive DFGin 6.9932 13.3738 BLAminus -127.18, 161.1 77.88, 88.72 -101.83, 19.04 301.72, 175.14 -66.37, -15.29 in-out in 8.7132 Saltbr-out 4.6046 HRD-in -77.44, -53.87 79.87, -4.46 out-in-out SNCoio in-out ActLoopNT-in 2.9328 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -119.46, 164.3 APE9-dihe-na -59.94, 165.51 APE8-dihe-in -60.21, 126.73 APE8-rot-in 299.02 APE67-dihe-in -60.44, -25.63 -60.52, -40.57 APE12-dist-in 10.3512 APE11-dist-out 6.2103 APE10-dist-out 9.0332 APE9-dist-in 3.8112 Q207D None None XRAY 1.33 0.162 0.182 B 301.0 290.0 3 32 32 0 [[207, 497]] 1.0 5s85 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S76B Q04771 205 499 509.0 LU8:501,02A:505 Type1,Type1.5_Back Inactive DFGin 7.0455 13.388 BLAminus -126.37, 161.8 77.8, 87.16 -99.2, 20.64 303.2, 173.97 -68.3, -17.34 in-out in 8.8877 Saltbr-out 4.7352 HRD-in -77.8, -54.12 78.31, -2.4 out-in-out SNCoio in-out ActLoopNT-in 2.9422 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.39, 162.33 APE9-dihe-na -57.18, 164.84 APE8-dihe-in -61.8, 127.01 APE8-rot-in 299.22 APE67-dihe-in -57.98, -30.25 -60.93, -39.7 APE12-dist-in 10.3885 APE11-dist-out 6.1918 APE10-dist-out 9.0776 APE9-dist-in 3.7583 Q207D None None XRAY 1.31 0.156 0.173 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s76 Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 5S9KB Q04771 205 499 509.0 LU8:501,YV4:505 Type1,Type3 Inactive DFGin 6.8994 13.3113 BLAminus -124.0, 163.62 77.74, 89.17 -103.64, 24.26 305.37, 1.01 -72.01, -17.07 in-out in 8.8119 Saltbr-out 4.6602 HRD-in -80.23, -51.12 77.76, -2.54 out-in-out SNCoio in-out ActLoopNT-in 2.9224 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.95, 165.67 APE9-dihe-na -60.95, 168.37 APE8-dihe-in -63.37, 128.29 APE8-rot-in 299.42 APE67-dihe-in -54.29, -31.02 -58.7, -45.73 APE12-dist-in 10.3307 APE11-dist-out 6.1855 APE10-dist-out 8.9921 APE9-dist-in 3.6866 Q207D None None XRAY 1.35 0.176 0.2 B 301.0 292.0 3 32 32 0 [[207, 497]] 1.0 5s9k Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1

Ligand: LU8

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name