Ligand: AN2

Total number of chains: 7
Active chains: 4
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 7 100.0% 4YHJA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC GRK4 GRK4_HUMAN 4YHJA P32298 25 525 578.0 AN2:601 ATPlike Active DFGin 6.129 13.3739 BLAminus -118.16, -176.89 50.04, 69.58 -89.94, 31.88 285.36, 98.48 -66.46, -45.19 in-in in 9.266 Saltbr-in 3.0263 HRD-in -63.35, -45.97 74.46, -21.42 in-in-in SNCiii in-in ActLoopNT-in 2.8551 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.22, 157.81 APE9-dihe-na 113.97, -154.87 APE8-dihe-in -108.33, 139.74 APE8-rot-in 312.15 APE67-dihe-inflip 104.58, -18.92 -61.34, 124.85 APE12-dist-in 11.4527 APE11-dist-in 12.8882 APE10-dist-in 6.916 APE9-dist-in 4.1454 C563S,C578S None None XRAY 2.6 0.2 0.248 A 584.0 501.0 0 27 27 0 [[187, 449]] 1.0 4yhj AGC_GRK4_HUMAN AGC 8.1e-84 286.9 1.0 260.0 260.0 329 330 331 333 335 216 235 239 309 311 310 312.0 368 356 351 350 349 348 347 346 345 265 G protein-coupled receptor kinase 4
AGC GRK4 GRK4_HUMAN 4YHJB P32298 25 527 578.0 AN2:601 ATPlike Active DFGin 6.0376 13.1721 BLAminus -128.85, 178.91 61.8, 67.7 -94.52, 28.72 287.39, 101.3 -65.66, -45.87 in-in in 9.0164 Saltbr-in 3.1793 HRD-in -66.59, -45.54 76.27, -17.2 in-in-in SNCiii in-in ActLoopNT-in 2.8759 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.9, 153.12 APE9-dihe-na 125.18, -147.1 APE8-dihe-in -118.5, 134.63 APE8-rot-in 298.66 APE67-dihe-inflip 107.33, -19.99 -54.96, 119.79 APE12-dist-in 11.1281 APE11-dist-in 12.752 APE10-dist-in 6.7744 APE9-dist-in 3.8163 C563S,C578S None None XRAY 2.6 0.2 0.248 B 584.0 490.0 0 27 27 0 [[187, 449]] 1.0 4yhj AGC_GRK4_HUMAN AGC 8.1e-84 286.9 1.0 260.0 260.0 329 330 331 333 335 216 235 239 309 311 310 312.0 368 356 351 350 349 348 347 346 345 265 G protein-coupled receptor kinase 4
CAMK DCLK1 DCLK1_HUMAN 5JZJA O15075 374 648 740.0 AN2:703 ATPlike Active DFGin 6.5586 14.4573 BLAminus -124.73, -164.54 49.76, 81.39 -91.62, 27.77 280.9, 72.89 -62.64, -30.24 in-in in 9.2641 Saltbr-in 2.9612 HRD-in -80.29, -46.18 67.47, 2.65 in-in-in SNCiii in-in ActLoopNT-in 2.8625 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.12, 159.65 APE9-dihe-na 123.02, -170.92 APE8-dihe-in -106.5, 129.13 APE8-rot-in 307.92 APE67-dihe-in -61.41, -36.29 -48.5, -40.56 APE12-dist-in 8.9521 APE11-dist-in 12.3251 APE10-dist-in 6.7423 APE9-dist-in 4.3062 None None None XRAY 1.71 0.178 0.208 A 297.0 271.0 4 25 25 0 [[390, 647]] 1.0 5jzj CAMK_DCLK1_HUMAN CAMK 7.6e-90 306.6 1.0 256.0 256.0 532 533 534 536 538 419 436 440 508 510 509 511.0 569 557 552 551 550 549 548 547 546 466 Serine/threonine-protein kinase DCLK1
CAMK DCLK1 DCLK1_HUMAN 5JZJB O15075 382 648 740.0 AN2:902 ATPlike Active DFGin 6.4026 14.4233 BLAminus -126.14, -167.19 53.32, 81.81 -94.99, 26.92 281.83, 75.21 -56.86, -35.14 in-in in 8.8064 Saltbr-in 2.6383 HRD-in -80.6, -45.11 67.98, 3.84 in-in-in SNCiii in-in ActLoopNT-in 2.8652 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.06, 162.17 APE9-dihe-na 120.91, -173.72 APE8-dihe-in -109.44, 126.03 APE8-rot-in 300.86 APE67-dihe-in -59.98, -31.53 -43.43, -44.7 APE12-dist-in 9.0437 APE11-dist-in 12.3582 APE10-dist-in 6.8315 APE9-dist-in 4.2744 None None None XRAY 1.71 0.178 0.208 B 297.0 261.0 6 25 25 0 [[390, 647]] 1.0 5jzj CAMK_DCLK1_HUMAN CAMK 7.6e-90 306.6 1.0 256.0 256.0 532 533 534 536 538 419 436 440 508 510 509 511.0 569 557 552 551 550 549 548 547 546 466 Serine/threonine-protein kinase DCLK1
CMGC MAPK1 MK01_HUMAN 8PSTA P28482 11 358 360.0 AN2:401,DC6:402 ATPlike,Allosteric Inactive DFGin 6.7851 16.1283 BLAminus -134.06, -179.16 64.02, 73.91 -96.68, 24.07 284.98, 72.99 -65.53, -24.17 in-out in 9.3377 Saltbr-out 3.8743 HRD-in -66.25, -48.73 76.74, -3.29 out-in-out SNCoio in-out ActLoopNT-in 2.739 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -76.72 APE8-dihe-in -121.88, 139.27 APE8-rot-out 177.73 APE67-dihe-in -63.49, -19.48 -93.88, -5.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.7648 None None None XRAY 1.9 0.192 0.224 A 364.0 333.0 15 31 18 13 [[25, 313]] 1.0 8pst CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PSWA P28482 11 358 360.0 AN2:401,D2I:402 ATPlike,Allosteric Inactive DFGin 6.8713 16.2525 BLAminus -133.24, 178.92 60.17, 81.49 -98.82, 18.4 283.05, 77.14 -62.53, -21.73 in-out in 9.4184 Saltbr-out 4.1301 HRD-in -71.12, -49.26 76.63, -3.5 out-in-out SNCoio in-out ActLoopNT-in 2.7674 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -97.92, 161.43 APE9-dihe-na -86.07, -39.89 APE8-dihe-in -109.3, 110.17 APE8-rot-in 302.88 APE67-dihe-in -69.34, -10.4 -107.51, 8.93 APE12-dist-none 999.0 APE11-dist-in 10.1783 APE10-dist-out 8.2941 APE9-dist-out 11.0742 None None None XRAY 2.0 0.191 0.215 A 364.0 338.0 10 31 21 10 [[25, 313]] 1.0 8psw CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PSYA P28482 11 358 360.0 AN2:401,EI0:402 ATPlike,Allosteric Inactive DFGin 6.977 16.2643 BLAminus -135.96, -178.59 63.47, 73.94 -97.05, 21.62 286.23, 79.85 -63.59, -23.12 in-out in 9.4371 Saltbr-out 4.3597 HRD-in -69.38, -42.87 69.92, -0.29 out-in-out SNCoio in-out ActLoopNT-in 2.8605 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -110.27, 143.52 APE9-dihe-na -55.43, -62.59 APE8-dihe-in -128.8, 133.66 APE8-rot-out 167.71 APE67-dihe-in -72.41, -12.11 -102.66, 18.87 APE12-dist-out 6.7454 APE11-dist-in 10.5215 APE10-dist-out 8.6185 APE9-dist-out 10.4447 None None None XRAY 2.55 0.192 0.232 A 364.0 340.0 8 31 23 8 [[25, 313]] 1.0 8psy CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1

Ligand: AN2

Total number of chains: 11
Active chains: 5
Total number of genes: 6
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 8 72.7% 5H9BA
DFGin None 3 27.3% 4BWPA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK CAMKII KCC2A_DROME 5H9BA Q00168 7 275 530.0 AN2:301 ATPlike Active DFGin 5.6874 14.1402 BLAminus -121.83, -177.58 63.45, 84.2 -103.14, 25.35 292.56, 80.33 -62.44, -18.79 in-in in 9.0142 Saltbr-in 2.6503 HRD-in -79.17, -42.13 69.98, 5.32 in-in-in SNCiii in-in ActLoopNT-in 3.0471 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.23, 154.68 APE9-dihe-na 138.91, -156.64 APE8-dihe-in -125.98, 126.82 APE8-rot-in 298.36 APE67-dihe-in -64.57, -17.97 -35.44, -64.1 APE12-dist-in 10.2174 APE11-dist-in 11.6886 APE10-dist-in 6.0156 APE9-dist-in 3.4186 None None None XRAY 2.25 0.204 0.222 A 285.0 269.0 0 28 28 0 [[14, 272]] 1.0 5h9b Drosophila melanogaster CAMK_CAMKII_DROME CAMK 6.3e-98 333.1 1.0 256.0 256.0 156 157 158 160 162 43 61 65 133 135 134 136.0 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II alpha chain
OTHER PAN3 PAN3_DROME 4BWPA Q95RR8 379 787 790.0 AN2:1788 ATPlike Pseudo DFGin 8.9872 13.2943 None -64.87, -46.72 -145.48, 65.79 -71.61, -40.0 313.19, 999.0 -67.11, -37.22 out-na out 16.8319 Saltbr-na 999.0 HRD-in -50.58, -30.55 79.2, -55.76 na-out-na SNCaoa out-na ActLoopNT-out 6.6977 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -83.44, -6.17 APE9-dihe-na -63.0, 138.21 APE8-dihe-na -120.41, 140.18 APE8-rot-na 194.81 APE67-dihe-na -113.46, 118.54 -59.4, -45.27 APE12-dist-na 5.3059 APE11-dist-na 5.8273 APE10-dist-na 8.8341 APE9-dist-na 12.3414 None None None XRAY 3.6 0.222 0.269 A 448.0 386.0 23 18 18 0 [[378, 664]] 1.0 4bwp Drosophila melanogaster OTHER_PAN3_DROME PAN3 1.2e-113 385.1 1.0 288.0 288.0 564 565 566 568 570 423 438 442 545 547 546 548.0 592 582 577 576 575 574 573 572 571 472 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_DROME 4BWPB Q95RR8 379 787 790.0 AN2:1788 ATPlike Pseudo DFGin 9.7361 13.9813 None -68.02, -47.7 -135.41, 45.28 -65.56, -36.8 296.47, 999.0 -63.81, -39.61 out-na out 16.5445 Saltbr-na 999.0 HRD-in -58.26, -35.46 80.55, -56.51 na-out-na SNCaoa out-na ActLoopNT-out 5.9619 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -88.2, -6.77 APE9-dihe-na -69.16, 143.64 APE8-dihe-na -96.5, 127.2 APE8-rot-na 212.33 APE67-dihe-na -115.77, 110.79 -63.6, -38.16 APE12-dist-na 4.419 APE11-dist-na 6.01 APE10-dist-na 8.8537 APE9-dist-na 11.2901 None None None XRAY 3.6 0.222 0.269 B 448.0 372.0 26 18 18 0 [[378, 664]] 1.0 4bwp Drosophila melanogaster OTHER_PAN3_DROME PAN3 1.2e-113 385.1 1.0 288.0 288.0 564 565 566 568 570 423 438 442 545 547 546 548.0 592 582 577 576 575 574 573 572 571 472 PAN2-PAN3 deadenylation complex subunit PAN3
AGC GRK4 GRK4_HUMAN 4YHJA P32298 25 525 578.0 AN2:601 ATPlike Active DFGin 6.129 13.3739 BLAminus -118.16, -176.89 50.04, 69.58 -89.94, 31.88 285.36, 98.48 -66.46, -45.19 in-in in 9.266 Saltbr-in 3.0263 HRD-in -63.35, -45.97 74.46, -21.42 in-in-in SNCiii in-in ActLoopNT-in 2.8551 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.22, 157.81 APE9-dihe-na 113.97, -154.87 APE8-dihe-in -108.33, 139.74 APE8-rot-in 312.15 APE67-dihe-inflip 104.58, -18.92 -61.34, 124.85 APE12-dist-in 11.4527 APE11-dist-in 12.8882 APE10-dist-in 6.916 APE9-dist-in 4.1454 C563S,C578S None None XRAY 2.6 0.2 0.248 A 584.0 501.0 0 27 27 0 [[187, 449]] 1.0 4yhj Homo sapiens AGC_GRK4_HUMAN AGC 8.1e-84 286.9 1.0 260.0 260.0 329 330 331 333 335 216 235 239 309 311 310 312.0 368 356 351 350 349 348 347 346 345 265 G protein-coupled receptor kinase 4
AGC GRK4 GRK4_HUMAN 4YHJB P32298 25 527 578.0 AN2:601 ATPlike Active DFGin 6.0376 13.1721 BLAminus -128.85, 178.91 61.8, 67.7 -94.52, 28.72 287.39, 101.3 -65.66, -45.87 in-in in 9.0164 Saltbr-in 3.1793 HRD-in -66.59, -45.54 76.27, -17.2 in-in-in SNCiii in-in ActLoopNT-in 2.8759 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.9, 153.12 APE9-dihe-na 125.18, -147.1 APE8-dihe-in -118.5, 134.63 APE8-rot-in 298.66 APE67-dihe-inflip 107.33, -19.99 -54.96, 119.79 APE12-dist-in 11.1281 APE11-dist-in 12.752 APE10-dist-in 6.7744 APE9-dist-in 3.8163 C563S,C578S None None XRAY 2.6 0.2 0.248 B 584.0 490.0 0 27 27 0 [[187, 449]] 1.0 4yhj Homo sapiens AGC_GRK4_HUMAN AGC 8.1e-84 286.9 1.0 260.0 260.0 329 330 331 333 335 216 235 239 309 311 310 312.0 368 356 351 350 349 348 347 346 345 265 G protein-coupled receptor kinase 4
CAMK DCLK1 DCLK1_HUMAN 5JZJA O15075 374 648 740.0 AN2:703 ATPlike Active DFGin 6.5586 14.4573 BLAminus -124.73, -164.54 49.76, 81.39 -91.62, 27.77 280.9, 72.89 -62.64, -30.24 in-in in 9.2641 Saltbr-in 2.9612 HRD-in -80.29, -46.18 67.47, 2.65 in-in-in SNCiii in-in ActLoopNT-in 2.8625 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.12, 159.65 APE9-dihe-na 123.02, -170.92 APE8-dihe-in -106.5, 129.13 APE8-rot-in 307.92 APE67-dihe-in -61.41, -36.29 -48.5, -40.56 APE12-dist-in 8.9521 APE11-dist-in 12.3251 APE10-dist-in 6.7423 APE9-dist-in 4.3062 None None None XRAY 1.71 0.178 0.208 A 297.0 271.0 4 25 25 0 [[390, 647]] 1.0 5jzj Homo sapiens CAMK_DCLK1_HUMAN CAMK 7.6e-90 306.6 1.0 256.0 256.0 532 533 534 536 538 419 436 440 508 510 509 511.0 569 557 552 551 550 549 548 547 546 466 Serine/threonine-protein kinase DCLK1
CAMK DCLK1 DCLK1_HUMAN 5JZJB O15075 382 648 740.0 AN2:902 ATPlike Active DFGin 6.4026 14.4233 BLAminus -126.14, -167.19 53.32, 81.81 -94.99, 26.92 281.83, 75.21 -56.86, -35.14 in-in in 8.8064 Saltbr-in 2.6383 HRD-in -80.6, -45.11 67.98, 3.84 in-in-in SNCiii in-in ActLoopNT-in 2.8652 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.06, 162.17 APE9-dihe-na 120.91, -173.72 APE8-dihe-in -109.44, 126.03 APE8-rot-in 300.86 APE67-dihe-in -59.98, -31.53 -43.43, -44.7 APE12-dist-in 9.0437 APE11-dist-in 12.3582 APE10-dist-in 6.8315 APE9-dist-in 4.2744 None None None XRAY 1.71 0.178 0.208 B 297.0 261.0 6 25 25 0 [[390, 647]] 1.0 5jzj Homo sapiens CAMK_DCLK1_HUMAN CAMK 7.6e-90 306.6 1.0 256.0 256.0 532 533 534 536 538 419 436 440 508 510 509 511.0 569 557 552 551 550 549 548 547 546 466 Serine/threonine-protein kinase DCLK1
CMGC MAPK1 MK01_HUMAN 8PSTA P28482 11 358 360.0 AN2:401,DC6:402 ATPlike,Allosteric Inactive DFGin 6.7851 16.1283 BLAminus -134.06, -179.16 64.02, 73.91 -96.68, 24.07 284.98, 72.99 -65.53, -24.17 in-out in 9.3377 Saltbr-out 3.8743 HRD-in -66.25, -48.73 76.74, -3.29 out-in-out SNCoio in-out ActLoopNT-in 2.739 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -76.72 APE8-dihe-in -121.88, 139.27 APE8-rot-out 177.73 APE67-dihe-in -63.49, -19.48 -93.88, -5.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.7648 None None None XRAY 1.9 0.192 0.224 A 364.0 333.0 15 31 18 13 [[25, 313]] 1.0 8pst Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PSWA P28482 11 358 360.0 AN2:401,D2I:402 ATPlike,Allosteric Inactive DFGin 6.8713 16.2525 BLAminus -133.24, 178.92 60.17, 81.49 -98.82, 18.4 283.05, 77.14 -62.53, -21.73 in-out in 9.4184 Saltbr-out 4.1301 HRD-in -71.12, -49.26 76.63, -3.5 out-in-out SNCoio in-out ActLoopNT-in 2.7674 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -97.92, 161.43 APE9-dihe-na -86.07, -39.89 APE8-dihe-in -109.3, 110.17 APE8-rot-in 302.88 APE67-dihe-in -69.34, -10.4 -107.51, 8.93 APE12-dist-none 999.0 APE11-dist-in 10.1783 APE10-dist-out 8.2941 APE9-dist-out 11.0742 None None None XRAY 2.0 0.191 0.215 A 364.0 338.0 10 31 21 10 [[25, 313]] 1.0 8psw Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PSYA P28482 11 358 360.0 AN2:401,EI0:402 ATPlike,Allosteric Inactive DFGin 6.977 16.2643 BLAminus -135.96, -178.59 63.47, 73.94 -97.05, 21.62 286.23, 79.85 -63.59, -23.12 in-out in 9.4371 Saltbr-out 4.3597 HRD-in -69.38, -42.87 69.92, -0.29 out-in-out SNCoio in-out ActLoopNT-in 2.8605 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -110.27, 143.52 APE9-dihe-na -55.43, -62.59 APE8-dihe-in -128.8, 133.66 APE8-rot-out 167.71 APE67-dihe-in -72.41, -12.11 -102.66, 18.87 APE12-dist-out 6.7454 APE11-dist-in 10.5215 APE10-dist-out 8.6185 APE9-dist-out 10.4447 None None None XRAY 2.55 0.192 0.232 A 364.0 340.0 8 31 23 8 [[25, 313]] 1.0 8psy Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
OTHER PINK1 PINK1_TRICA 7MP9A D6WMX4 121 568 570.0 AN2:609 ATPlike Inactive DFGin 9.4917 15.077 None -107.5, -68.6 -79.29, 107.71 -103.85, 17.12 271.24, 68.18 -70.55, -9.3 in-in in 7.8201 Saltbr-in 2.482 HRD-in -85.61, -44.31 63.96, 13.98 in-in-in SNCiii in-in ActLoopNT-in 2.7063 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 122.7, -149.63 APE9-dihe-na -104.04, -111.12 APE8-dihe-in -65.26, 151.5 APE8-rot-na 80.98 APE67-dihe-in -70.22, -49.9 -101.67, -4.86 APE12-dist-in 7.9325 APE11-dist-in 10.2637 APE10-dist-in 5.6129 APE9-dist-in 3.4397 None SEP205,TPO530 SEP205,TPO530 XRAY 2.8 0.25 0.306 A 455.0 414.0 31 34 34 0 [[61, 504]] 1.0 7mp9 Tribolium castaneum OTHER_PINK1_TRICA PINK1 3.5e-89 305.2 5.0 367.0 363.0 358 359 360 362 364 196 217 221 334 336 335 337.0 410 392 387 386 385 384 383 382 381 295 Serine/threonine-protein kinase Pink1, mitochondrial

Ligand: AN2

Total number of chains: 4
Active chains: 1
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 3 75.0% 4BWPA
DFGin BLAminus 1 25.0% 5H9BA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK CAMKII KCC2A_DROME 5H9BA Q00168 7 275 530.0 AN2:301 ATPlike Active DFGin 5.6874 14.1402 BLAminus -121.83, -177.58 63.45, 84.2 -103.14, 25.35 292.56, 80.33 -62.44, -18.79 in-in in 9.0142 Saltbr-in 2.6503 HRD-in -79.17, -42.13 69.98, 5.32 in-in-in SNCiii in-in ActLoopNT-in 3.0471 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.23, 154.68 APE9-dihe-na 138.91, -156.64 APE8-dihe-in -125.98, 126.82 APE8-rot-in 298.36 APE67-dihe-in -64.57, -17.97 -35.44, -64.1 APE12-dist-in 10.2174 APE11-dist-in 11.6886 APE10-dist-in 6.0156 APE9-dist-in 3.4186 None None None XRAY 2.25 0.204 0.222 A 285.0 269.0 0 28 28 0 [[14, 272]] 1.0 5h9b Drosophila melanogaster CAMK_CAMKII_DROME CAMK 6.3e-98 333.1 1.0 256.0 256.0 156 157 158 160 162 43 61 65 133 135 134 136.0 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II alpha chain
OTHER PAN3 PAN3_DROME 4BWPA Q95RR8 379 787 790.0 AN2:1788 ATPlike Pseudo DFGin 8.9872 13.2943 None -64.87, -46.72 -145.48, 65.79 -71.61, -40.0 313.19, 999.0 -67.11, -37.22 out-na out 16.8319 Saltbr-na 999.0 HRD-in -50.58, -30.55 79.2, -55.76 na-out-na SNCaoa out-na ActLoopNT-out 6.6977 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -83.44, -6.17 APE9-dihe-na -63.0, 138.21 APE8-dihe-na -120.41, 140.18 APE8-rot-na 194.81 APE67-dihe-na -113.46, 118.54 -59.4, -45.27 APE12-dist-na 5.3059 APE11-dist-na 5.8273 APE10-dist-na 8.8341 APE9-dist-na 12.3414 None None None XRAY 3.6 0.222 0.269 A 448.0 386.0 23 18 18 0 [[378, 664]] 1.0 4bwp Drosophila melanogaster OTHER_PAN3_DROME PAN3 1.2e-113 385.1 1.0 288.0 288.0 564 565 566 568 570 423 438 442 545 547 546 548.0 592 582 577 576 575 574 573 572 571 472 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_DROME 4BWPB Q95RR8 379 787 790.0 AN2:1788 ATPlike Pseudo DFGin 9.7361 13.9813 None -68.02, -47.7 -135.41, 45.28 -65.56, -36.8 296.47, 999.0 -63.81, -39.61 out-na out 16.5445 Saltbr-na 999.0 HRD-in -58.26, -35.46 80.55, -56.51 na-out-na SNCaoa out-na ActLoopNT-out 5.9619 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -88.2, -6.77 APE9-dihe-na -69.16, 143.64 APE8-dihe-na -96.5, 127.2 APE8-rot-na 212.33 APE67-dihe-na -115.77, 110.79 -63.6, -38.16 APE12-dist-na 4.419 APE11-dist-na 6.01 APE10-dist-na 8.8537 APE9-dist-na 11.2901 None None None XRAY 3.6 0.222 0.269 B 448.0 372.0 26 18 18 0 [[378, 664]] 1.0 4bwp Drosophila melanogaster OTHER_PAN3_DROME PAN3 1.2e-113 385.1 1.0 288.0 288.0 564 565 566 568 570 423 438 442 545 547 546 548.0 592 582 577 576 575 574 573 572 571 472 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PINK1 PINK1_TRICA 7MP9A D6WMX4 121 568 570.0 AN2:609 ATPlike Inactive DFGin 9.4917 15.077 None -107.5, -68.6 -79.29, 107.71 -103.85, 17.12 271.24, 68.18 -70.55, -9.3 in-in in 7.8201 Saltbr-in 2.482 HRD-in -85.61, -44.31 63.96, 13.98 in-in-in SNCiii in-in ActLoopNT-in 2.7063 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 122.7, -149.63 APE9-dihe-na -104.04, -111.12 APE8-dihe-in -65.26, 151.5 APE8-rot-na 80.98 APE67-dihe-in -70.22, -49.9 -101.67, -4.86 APE12-dist-in 7.9325 APE11-dist-in 10.2637 APE10-dist-in 5.6129 APE9-dist-in 3.4397 None SEP205,TPO530 SEP205,TPO530 XRAY 2.8 0.25 0.306 A 455.0 414.0 31 34 34 0 [[61, 504]] 1.0 7mp9 Tribolium castaneum OTHER_PINK1_TRICA PINK1 3.5e-89 305.2 5.0 367.0 363.0 358 359 360 362 364 196 217 221 334 336 335 337.0 410 392 387 386 385 384 383 382 381 295 Serine/threonine-protein kinase Pink1, mitochondrial