TYR_TYK2-2 (Non-receptor tyrosine-protein kinase TYK2)

Total number of chains: 31
Uniprot: TYK2_HUMAN
Kinase Domain Residues: 897 - 1171
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 15 AF-P29597-K2A
DFGin ABAminus 15 6DBKA
DFGin None 1 4GIIA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
7UYRA 2.15 Inactive DFGin‑ABAminus in-out in-none OVI Type1 890 - 1177 6 X1054,X1055 None Non-receptor tyrosine-protein kinase TYK2
4PY1A 2.16 Inactive DFGin‑ABAminus in-in in-out 2YK Type1 889 - 1178 0 X1054 C936A,Q969A,E971A,K972A,A1016S,C1142A Non-receptor tyrosine-protein kinase TYK2
6DBKA 2.0 Inactive DFGin‑ABAminus in-in in-out G5D Type1 889 - 1178 0 X1054 C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2
6DBMA 2.368 Inactive DFGin‑ABAminus in-in in-out G4J Type1 889 - 1178 3 X1054 C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2
6VNSA 2.09 Inactive DFGin‑ABAminus in-in in-out R5D Type1 889 - 1178 0 X1054 C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2
6VNVA 2.15 Inactive DFGin‑ABAminus in-in in-out R4Y Type1 889 - 1178 0 X1054 C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2
6VNXA 2.18 Inactive DFGin‑ABAminus in-in in-out R4V Type1 889 - 1178 0 X1054 C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2
6VNYA 2.3 Inactive DFGin‑ABAminus in-in in-out R4S Type1 889 - 1178 3 X1054 C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2
6X8FA 2.15 Inactive DFGin‑ABAminus in-in in-out UWP Type1 889 - 1178 0 X1054 C936A,Q969A,E971A,K972A,A1016S,C1142A Non-receptor tyrosine-protein kinase TYK2
6X8FC 2.15 Inactive DFGin‑ABAminus in-in in-out UWP Type1 889 - 1178 0 X1054 C936A,Q969A,E971A,K972A,A1016S,C1142A Non-receptor tyrosine-protein kinase TYK2
6X8GA 2.21 Inactive DFGin‑ABAminus in-in in-out UWM Type1 889 - 1178 2 X1054 C936A,Q969A,E971A,K972A,A1016S,C1142A Non-receptor tyrosine-protein kinase TYK2
3LXNA 2.5 Inactive DFGin‑ABAminus in-in in-out MI1 Type1 888 - 1178 3 X1054 C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2
4GJ2A 2.4 Inactive DFGin‑ABAminus in-in in-out 0XH Type1 890 - 1176 0 None C936A,Q969A,E971A,K972A,D1023N,C1142A Non-receptor tyrosine-protein kinase TYK2
4GJ3A 2.5 Inactive DFGin‑ABAminus in-in in-out 0XP Type1 890 - 1176 0 None C936A,Q969A,E971A,K972A,D1023N,C1142A Non-receptor tyrosine-protein kinase TYK2
5WALA 2.45 Inactive DFGin‑ABAminus in-in in-out 9ZS Type1 890 - 1176 2 None C936A,Q969A,E971A,K972A,D1023N,C1142A Non-receptor tyrosine-protein kinase TYK2
AF-P29597-K2A -1.0 Active DFGin‑BLAminus in-in in-in No_ligand No_ligand 889 - 1179 0 None None Non-receptor tyrosine-protein kinase TYK2
AF-P29597-K4A -1.0 Active DFGin‑BLAminus in-in in-in No_ligand No_ligand 889 - 1179 0 None None Non-receptor tyrosine-protein kinase TYK2
7UYSA 2.15 None DFGin‑BLAminus in-in in-none OVC Type1 890 - 1177 4 X1054,X1055 None Non-receptor tyrosine-protein kinase TYK2
7UYTA 2.14 Active DFGin‑BLAminus in-in in-in OV5 Type1 890 - 1177 2 X1054,X1055 None Non-receptor tyrosine-protein kinase TYK2
7UYUA 2.05 None DFGin‑BLAminus in-in in-none OV0 Type1 889 - 1177 7 X1054,X1055 None Non-receptor tyrosine-protein kinase TYK2
4GVJA 2.03 Inactive DFGin‑BLAminus in-in in-out ADP Type1 889 - 1176 0 None C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2
3LXPA 1.65 Active DFGin‑BLAminus in-in in-in IZA Type1 888 - 1178 3 X1054 C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2
5F1ZA 2.65 Active DFGin‑BLAminus in-in in-in 5U3 Type1 886 - 1176 0 None None Non-receptor tyrosine-protein kinase TYK2
5F20A 2.91 Active DFGin‑BLAminus in-in in-in 5U4 Type1 888 - 1176 0 None None Non-receptor tyrosine-protein kinase TYK2
6OVAA 2.5 Active DFGin‑BLAminus in-in in-in N9G Type1 888 - 1175 0 None None Non-receptor tyrosine-protein kinase TYK2
4GFOA 2.3 Inactive DFGin‑BLAminus in-out in-in 0X2 Type1 890 - 1176 0 None D1023N Non-receptor tyrosine-protein kinase TYK2
3NZ0A 2.0 Inactive DFGin‑BLAminus in-in in-out IZA Type1 888 - 1176 0 None D1023N Non-receptor tyrosine-protein kinase TYK2
6AAMA 1.98 None DFGin‑BLAminus in-in in-none 9T6 Type1 888 - 1178 14 None C936A,Q969A,E971A,K972A,D1023N,I1114L,C1142A Non-receptor tyrosine-protein kinase TYK2
4GIHA 2.0 Inactive DFGin‑BLAminus in-in in-out 0X5 Type1 890 - 1176 0 None C936A,Q969A,E971A,K972A,D1023N,C1142A Non-receptor tyrosine-protein kinase TYK2
3NYXA 2.5 Inactive DFGin‑BLAminus out-out in-in TZ1 Type1.5_Back 889 - 1176 0 None D1023N Non-receptor tyrosine-protein kinase TYK2
4GIIA 2.31 Inactive DFGin‑None in-in in-out 0X6 Type1 890 - 1176 0 None C936A,Q969A,E971A,K972A,D1023N,C1142A Non-receptor tyrosine-protein kinase TYK2

TYR_TYK2-2 (Non-receptor tyrosine-protein kinase TYK2)

Total number of chains: 33
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 15 AF-P29597-K2A
DFGin ABAminus 17 6DBKA
DFGin None 1 4GIIA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYK2_HUMAN 7UYRA 2.15 Inactive DFGin‑ABAminus in-out in-none OVI Type1 890 - 1177 6 X1054,X1055 None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 4PY1A 2.16 Inactive DFGin‑ABAminus in-in in-out 2YK Type1 889 - 1178 0 X1054 C936A,Q969A,E971A,K972A,A1016S,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 6DBKA 2.0 Inactive DFGin‑ABAminus in-in in-out G5D Type1 889 - 1178 0 X1054 C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 6DBMA 2.368 Inactive DFGin‑ABAminus in-in in-out G4J Type1 889 - 1178 3 X1054 C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 6VNSA 2.09 Inactive DFGin‑ABAminus in-in in-out R5D Type1 889 - 1178 0 X1054 C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 6VNVA 2.15 Inactive DFGin‑ABAminus in-in in-out R4Y Type1 889 - 1178 0 X1054 C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 6VNXA 2.18 Inactive DFGin‑ABAminus in-in in-out R4V Type1 889 - 1178 0 X1054 C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 6VNYA 2.3 Inactive DFGin‑ABAminus in-in in-out R4S Type1 889 - 1178 3 X1054 C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 6X8FA 2.15 Inactive DFGin‑ABAminus in-in in-out UWP Type1 889 - 1178 0 X1054 C936A,Q969A,E971A,K972A,A1016S,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 6X8FC 2.15 Inactive DFGin‑ABAminus in-in in-out UWP Type1 889 - 1178 0 X1054 C936A,Q969A,E971A,K972A,A1016S,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 6X8GA 2.21 Inactive DFGin‑ABAminus in-in in-out UWM Type1 889 - 1178 2 X1054 C936A,Q969A,E971A,K972A,A1016S,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 3LXNA 2.5 Inactive DFGin‑ABAminus in-in in-out MI1 Type1 888 - 1178 3 X1054 C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 4GJ2A 2.4 Inactive DFGin‑ABAminus in-in in-out 0XH Type1 890 - 1176 0 None C936A,Q969A,E971A,K972A,D1023N,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 4GJ3A 2.5 Inactive DFGin‑ABAminus in-in in-out 0XP Type1 890 - 1176 0 None C936A,Q969A,E971A,K972A,D1023N,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 5WALA 2.45 Inactive DFGin‑ABAminus in-in in-out 9ZS Type1 890 - 1176 2 None C936A,Q969A,E971A,K972A,D1023N,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN AF-P29597-K2A -1.0 Active DFGin‑BLAminus in-in in-in No_ligand No_ligand 889 - 1179 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN AF-P29597-K4A -1.0 Active DFGin‑BLAminus in-in in-in No_ligand No_ligand 889 - 1179 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 7UYSA 2.15 None DFGin‑BLAminus in-in in-none OVC Type1 890 - 1177 4 X1054,X1055 None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 7UYTA 2.14 Active DFGin‑BLAminus in-in in-in OV5 Type1 890 - 1177 2 X1054,X1055 None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 7UYUA 2.05 None DFGin‑BLAminus in-in in-none OV0 Type1 889 - 1177 7 X1054,X1055 None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 4GVJA 2.03 Inactive DFGin‑BLAminus in-in in-out ADP Type1 889 - 1176 0 None C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 3LXPA 1.65 Active DFGin‑BLAminus in-in in-in IZA Type1 888 - 1178 3 X1054 C936A,Q969A,E971A,K972A,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 5F1ZA 2.65 Active DFGin‑BLAminus in-in in-in 5U3 Type1 886 - 1176 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 5F20A 2.91 Active DFGin‑BLAminus in-in in-in 5U4 Type1 888 - 1176 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 6OVAA 2.5 Active DFGin‑BLAminus in-in in-in N9G Type1 888 - 1175 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 4GFOA 2.3 Inactive DFGin‑BLAminus in-out in-in 0X2 Type1 890 - 1176 0 None D1023N Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 3NZ0A 2.0 Inactive DFGin‑BLAminus in-in in-out IZA Type1 888 - 1176 0 None D1023N Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 6AAMA 1.98 None DFGin‑BLAminus in-in in-none 9T6 Type1 888 - 1178 14 None C936A,Q969A,E971A,K972A,D1023N,I1114L,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 4GIHA 2.0 Inactive DFGin‑BLAminus in-in in-out 0X5 Type1 890 - 1176 0 None C936A,Q969A,E971A,K972A,D1023N,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 3NYXA 2.5 Inactive DFGin‑BLAminus out-out in-in TZ1 Type1.5_Back 889 - 1176 0 None D1023N Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_HUMAN 4GIIA 2.31 Inactive DFGin‑None in-in in-out 0X6 Type1 890 - 1176 0 None C936A,Q969A,E971A,K972A,D1023N,C1142A Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYK2_MOUSE 4E20A 2.6 Inactive DFGin‑ABAminus in-in in-out 0MY Type1 885 - 1174 0 None D1020A Non-receptor tyrosine-protein kinase TYK2 Mus musculus
TYK2_MOUSE 4E1ZA 2.5 Inactive DFGin‑ABAminus in-in in-out 0MX Type1 884 - 1174 0 None D1020A Non-receptor tyrosine-protein kinase TYK2 Mus musculus

TYR_TYK2-2 (Non-receptor tyrosine-protein kinase TYK2)

Total number of chains: 2
Spatial label Dihedral label Number of Chains Representative
DFGin ABAminus 2 4E1ZA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYK2_MOUSE 4E20A 2.6 Inactive DFGin‑ABAminus in-in in-out 0MY Type1 885 - 1174 0 None D1020A Non-receptor tyrosine-protein kinase TYK2 Mus musculus
TYK2_MOUSE 4E1ZA 2.5 Inactive DFGin‑ABAminus in-in in-out 0MX Type1 884 - 1174 0 None D1020A Non-receptor tyrosine-protein kinase TYK2 Mus musculus