TYR_TYK2-2 (Non-receptor tyrosine-protein kinase TYK2)

Total number of chains: 31
Active chains: 7
Family: TYR
Uniprot: TYK2_HUMAN
Kinase Domain Residues: 897 - 1171
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 15 48.4% 6DBKA
DFGin BLAminus 15 48.4% AF-P29597-K2A
DFGin None 1 3.2% 4GIIA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P29597-K2A 889 1179 1187.0 No_ligand No_ligand Active DFGin 6.266 13.856 BLAminus -129.16, -172.6 52.17, 81.1 -91.4, 17.41 289.14, 86.02 -61.92, -27.42 in-in in 8.383 Saltbr-in 2.674 HRD-in -70.25, -42.3 64.49, -12.74 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.3, 122.99 APE9-dihe-in -124.95, 133.41 APE8-dihe-in -75.89, 67.63 APE8-rot-na 35.61 APE67-dihe-in -74.56, -10.56 -54.18, -28.6 APE12-dist-na 13.657 APE11-dist-na 9.815 APE10-dist-na 10.236 APE9-dist-in 7.061 None None None AF2 -1.0 1.0 1.0 A 291 291 0 0 0 0 [[589, 868], [897, 1171]] 2.0 AF-P29597-K2 TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
AF-P29597-K4A 889 1179 1187.0 No_ligand No_ligand Active DFGin 6.336 13.879 BLAminus -129.55, -171.63 53.38, 74.68 -84.95, 17.18 288.9, 80.46 -62.16, -27.19 in-in in 8.326 Saltbr-in 2.659 HRD-in -79.84, -43.53 59.12, -2.49 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -59.44, 131.09 APE9-dihe-in -129.28, 129.49 APE8-dihe-in -73.84, 63.43 APE8-rot-na 35.77 APE67-dihe-in -74.2, -11.8 -53.93, -29.14 APE12-dist-na 12.864 APE11-dist-na 9.455 APE10-dist-na 9.489 APE9-dist-in 6.739 None None None AF2 -1.0 1.0 1.0 A 291 291 0 0 0 0 [[589, 868], [897, 1171]] 2.0 AF-P29597-K4 TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
7UYTA 890 1177 1187.0 OV5:1201 Type1 Active DFGin 6.6 13.563 BLAminus -113.96, -166.72 43.12, 92.69 -104.69, 31.01 290.99, 83.76 -63.14, -33.25 in-in in 7.554 Saltbr-in 3.173 HRD-in -84.86, -57.24 78.5, -1.23 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.23, 72.86 APE9-dihe-in -74.56, 127.74 APE8-dihe-in -83.18, 74.68 APE8-rot-na 37.06 APE67-dihe-in -71.62, -8.97 -55.74, -33.87 APE12-dist-na 12.592 APE11-dist-na 9.028 APE10-dist-na 9.2 APE9-dist-in 6.489 None PTR1054,PTR1055 PTR1054,PTR1055 XRAY 2.14 0.245 0.293 A 289 278 10 0 0 2 [[589, 868], [897, 1171]] 2.0 7uyt TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
3LXPA 888 1178 1187.0 IZA:1183 Type1 Active DFGin 6.516 14.068 BLAminus -125.49, -162.27 32.56, 69.7 -75.76, 18.49 286.14, 89.4 -52.16, -34.42 in-in in 8.353 Saltbr-in 2.576 HRD-in -85.74, -50.8 74.46, 2.83 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -90.42, 114.17 APE9-dihe-in -102.81, 153.1 APE8-dihe-in -78.99, 64.19 APE8-rot-na 29.2 APE67-dihe-in -72.53, -2.22 -56.28, -30.53 APE12-dist-na 999.0 APE11-dist-na 10.927 APE10-dist-na 11.281 APE9-dist-in 6.778 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 1.65 0.194 0.229 A 318 286 5 0 0 3 [[589, 868], [897, 1171]] 2.0 3lxp TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
5F1ZA 886 1176 1187.0 5U3:61200 Type1 Active DFGin 6.206 13.956 BLAminus -129.2, -165.99 40.61, 85.28 -97.37, 33.45 284.09, 63.85 -64.96, -27.88 in-in in 7.536 Saltbr-in 3.04 HRD-in -91.41, -43.93 63.21, 17.11 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.48, 145.93 APE9-dihe-in -146.94, 155.61 APE8-dihe-in -74.89, 73.59 APE8-rot-na 30.25 APE67-dihe-in -77.49, 3.7 -64.13, -25.53 APE12-dist-na 12.687 APE11-dist-na 11.388 APE10-dist-na 11.106 APE9-dist-in 6.587 None None None XRAY 2.65 0.22 0.31 A 301 280 11 0 0 0 [[589, 868], [897, 1171]] 2.0 5f1z TYR_TYK2-2_HUMAN TYR 2.2e-81 279.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
5F20A 888 1176 1187.0 5U4:1200 Type1 Active DFGin 6.403 13.645 BLAminus -113.81, -158.54 31.35, 78.87 -88.8, 21.81 284.42, 71.86 -44.97, -45.07 in-in in 7.343 Saltbr-in 3.308 HRD-in -78.86, -34.24 65.78, -0.57 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.24, 144.87 APE9-dihe-in -130.77, 139.79 APE8-dihe-in -66.89, 65.4 APE8-rot-na 26.96 APE67-dihe-in -83.29, -2.83 -63.91, -21.29 APE12-dist-na 11.279 APE11-dist-na 11.394 APE10-dist-na 11.008 APE9-dist-in 7.023 None None None XRAY 2.91 0.205 0.288 A 301 274 15 0 0 0 [[589, 868], [897, 1171]] 2.0 5f20 TYR_TYK2-2_HUMAN TYR 2.2e-81 279.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
6OVAA 888 1175 1187.0 N9G:1200 Type1 Active DFGin 6.351 13.943 BLAminus -130.49, -167.36 38.71, 89.63 -96.32, 19.31 284.72, 70.82 -52.83, -28.66 in-in in 7.822 Saltbr-in 2.787 HRD-in -92.56, -54.5 71.46, 13.79 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.41, 141.23 APE9-dihe-in -150.02, 159.37 APE8-dihe-in -76.58, 70.53 APE8-rot-na 23.86 APE67-dihe-in -75.33, -2.58 -60.5, -26.47 APE12-dist-na 12.05 APE11-dist-na 11.277 APE10-dist-na 11.033 APE9-dist-in 6.377 None None None XRAY 2.5 0.2 0.251 A 301 273 15 0 0 0 [[589, 868], [897, 1171]] 2.0 6ova TYR_TYK2-2_HUMAN TYR 2.2e-81 279.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
7UYRA 890 1177 1187.0 OVI:1201 Type1 Inactive DFGin 6.893 13.575 ABAminus -115.92, -24.42 -138.27, 134.13 -131.63, 30.54 291.7, 86.26 -68.73, -29.22 in-out in 7.844 Saltbr-out 4.253 HRD-in -84.33, -53.98 75.58, 8.54 out-in-none SNCoin in-none ActLoopNT-in 2.808 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -62.06 APE9-dihe-in -73.92, 136.51 APE8-dihe-in -78.67, 70.61 APE8-rot-na 29.09 APE67-dihe-in -73.97, -8.9 -61.21, -30.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.808 APE9-dist-in 6.71 None PTR1054,PTR1055 PTR1054,PTR1055 XRAY 2.15 0.205 0.259 A 289 282 6 0 0 6 [[589, 868], [897, 1171]] 2.0 7uyr TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
4PY1A 889 1178 1187.0 2YK:1201 Type1 Inactive DFGin 6.893 13.579 ABAminus -113.0, -22.09 -124.57, 117.57 -104.94, 28.18 290.62, 81.68 -57.39, -32.81 in-in in 8.377 Saltbr-in 2.741 HRD-in -78.12, -49.58 73.18, -2.6 in-in-out SNCiio in-out ActLoopNT-in 2.796 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -99.39, 3.55 APE9-dihe-in -62.33, 127.2 APE8-dihe-in -77.67, 66.69 APE8-rot-na 30.36 APE67-dihe-in -75.63, -5.27 -51.36, -32.2 APE12-dist-na 10.374 APE11-dist-na 13.139 APE10-dist-na 9.565 APE9-dist-in 6.864 C936A,Q969A,E971A,K972A,A1016S,C1142A PTR1054 PTR1054 XRAY 2.16 0.184 0.236 A 318 290 0 0 0 0 [[589, 868], [897, 1171]] 2.0 4py1 TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
6DBKA 889 1178 1187.0 G5D:4000 Type1 Inactive DFGin 6.754 13.312 ABAminus -108.33, 3.25 -147.57, 142.28 -132.84, 28.54 296.5, 85.96 -50.88, -35.67 in-in in 8.37 Saltbr-in 2.75 HRD-in -80.67, -52.64 72.46, -2.15 in-in-out SNCiio in-out ActLoopNT-in 2.866 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -99.35, 0.82 APE9-dihe-in -54.67, 132.67 APE8-dihe-in -80.05, 71.48 APE8-rot-na 29.23 APE67-dihe-in -72.51, -5.27 -51.63, -35.72 APE12-dist-na 10.052 APE11-dist-na 13.16 APE10-dist-na 10.012 APE9-dist-in 6.734 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 2.0 0.203 0.249 A 318 290 0 0 0 0 [[589, 868], [897, 1171]] 2.0 6dbk TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
6DBMA 889 1178 1187.0 G4J:4000 Type1 Inactive DFGin 6.402 13.381 ABAminus -104.02, 1.7 -152.49, 145.86 -137.95, 42.02 302.25, 86.41 -67.57, -26.89 in-in in 8.851 Saltbr-in 2.699 HRD-in -93.72, -57.81 77.91, 10.17 in-in-out SNCiio in-out ActLoopNT-in 2.869 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -82.24, 0.6 APE9-dihe-in -73.63, 132.77 APE8-dihe-in -74.36, 72.39 APE8-rot-na 28.5 APE67-dihe-in -74.28, -1.08 -60.7, -31.84 APE12-dist-na 10.078 APE11-dist-na 13.186 APE10-dist-na 9.685 APE9-dist-in 6.421 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 2.368 0.204 0.264 A 318 274 16 0 0 3 [[589, 868], [897, 1171]] 2.0 6dbm TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
6VNSA 889 1178 1187.0 R5D:4000 Type1 Inactive DFGin 6.658 13.506 ABAminus -108.04, 9.42 -153.13, 141.48 -134.56, 31.14 297.55, 90.4 -55.34, -27.89 in-in in 8.392 Saltbr-in 2.759 HRD-in -80.98, -51.2 72.5, -3.91 in-in-out SNCiio in-out ActLoopNT-in 2.946 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -93.89, 0.93 APE9-dihe-in -68.47, 124.35 APE8-dihe-in -77.47, 69.41 APE8-rot-na 29.48 APE67-dihe-in -77.69, -3.72 -52.06, -30.79 APE12-dist-na 10.45 APE11-dist-na 13.118 APE10-dist-na 9.228 APE9-dist-in 6.757 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 2.09 0.188 0.231 A 318 290 0 0 0 0 [[589, 868], [897, 1171]] 2.0 6vns TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
6VNVA 889 1178 1187.0 R4Y:4000 Type1 Inactive DFGin 6.346 13.404 ABAminus -109.84, 1.0 -145.58, 142.68 -134.32, 29.59 295.91, 88.64 -55.43, -34.03 in-in in 8.342 Saltbr-in 2.751 HRD-in -83.86, -49.18 65.87, 7.87 in-in-out SNCiio in-out ActLoopNT-in 2.903 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.02, 18.68 APE9-dihe-in -71.67, 138.4 APE8-dihe-in -78.48, 67.28 APE8-rot-na 26.2 APE67-dihe-in -77.83, -5.33 -55.89, -29.32 APE12-dist-na 9.804 APE11-dist-na 13.241 APE10-dist-na 10.029 APE9-dist-in 6.585 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 2.15 0.189 0.238 A 318 275 15 0 0 0 [[589, 868], [897, 1171]] 2.0 6vnv TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
6VNXA 889 1178 1187.0 R4V:4000 Type1 Inactive DFGin 6.778 13.489 ABAminus -107.68, 5.81 -147.51, 139.03 -132.77, 32.03 296.4, 87.46 -59.82, -29.87 in-in in 8.48 Saltbr-in 2.845 HRD-in -78.78, -53.6 74.67, -1.35 in-in-out SNCiio in-out ActLoopNT-in 2.8 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -93.13, 2.52 APE9-dihe-in -67.17, 125.69 APE8-dihe-in -78.92, 68.35 APE8-rot-na 29.46 APE67-dihe-in -78.75, -0.47 -50.92, -34.17 APE12-dist-na 10.71 APE11-dist-na 13.129 APE10-dist-na 9.408 APE9-dist-in 6.782 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 2.18 0.196 0.238 A 318 290 0 0 0 0 [[589, 868], [897, 1171]] 2.0 6vnx TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
6VNYA 889 1178 1187.0 R4S:4000 Type1 Inactive DFGin 6.71 13.642 ABAminus -108.42, 4.15 -147.63, 142.15 -133.65, 30.43 294.62, 90.13 -52.87, -33.85 in-in in 8.231 Saltbr-in 2.778 HRD-in -77.71, -50.71 72.39, -6.46 in-in-out SNCiio in-out ActLoopNT-in 2.81 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -94.29, 3.77 APE9-dihe-in -73.55, 133.09 APE8-dihe-in -79.53, 66.39 APE8-rot-na 27.75 APE67-dihe-in -77.39, 0.21 -51.74, -32.37 APE12-dist-na 10.406 APE11-dist-na 13.35 APE10-dist-na 9.706 APE9-dist-in 6.771 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 2.3 0.176 0.229 A 318 287 3 0 0 3 [[589, 868], [897, 1171]] 2.0 6vny TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
6X8FA 889 1178 1187.0 UWP:4001 Type1 Inactive DFGin 6.368 13.443 ABAminus -95.56, -18.62 -136.08, 142.25 -132.97, 38.39 300.79, 80.69 -60.74, -30.23 in-in in 8.59 Saltbr-in 2.814 HRD-in -80.09, -50.24 67.91, 4.2 in-in-out SNCiio in-out ActLoopNT-in 2.813 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -85.77, 10.94 APE9-dihe-in -74.28, 130.62 APE8-dihe-in -82.04, 69.42 APE8-rot-na 28.67 APE67-dihe-in -81.13, -2.61 -51.22, -29.34 APE12-dist-na 9.813 APE11-dist-na 12.675 APE10-dist-na 9.193 APE9-dist-in 6.525 C936A,Q969A,E971A,K972A,A1016S,C1142A PTR1054 PTR1054 XRAY 2.15 0.208 0.255 A 318 283 7 0 0 0 [[589, 868], [897, 1171]] 2.0 6x8f TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
6X8FC 889 1178 1187.0 UWP:4000 Type1 Inactive DFGin 6.411 13.467 ABAminus -95.34, -17.32 -136.72, 141.32 -133.98, 37.29 300.65, 80.99 -60.17, -32.21 in-in in 8.489 Saltbr-in 2.696 HRD-in -78.97, -50.37 67.86, 4.05 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -92.16, 9.73 APE9-dihe-in -74.69, 130.77 APE8-dihe-in -82.29, 70.3 APE8-rot-na 28.25 APE67-dihe-in -80.62, -2.35 -52.14, -29.87 APE12-dist-na 10.892 APE11-dist-na 12.859 APE10-dist-na 9.189 APE9-dist-in 6.55 C936A,Q969A,E971A,K972A,A1016S,C1142A PTR1054 PTR1054 XRAY 2.15 0.208 0.255 C 318 290 0 0 0 0 [[589, 868], [897, 1171]] 2.0 6x8f TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
6X8GA 889 1178 1187.0 UWM:4000 Type1 Inactive DFGin 6.36 13.409 ABAminus -102.36, -12.35 -141.17, 141.98 -131.51, 29.12 299.29, 85.37 -56.7, -31.51 in-in in 8.753 Saltbr-in 2.795 HRD-in -84.67, -51.08 70.92, -1.88 in-in-out SNCiio in-out ActLoopNT-in 2.834 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -92.94, 4.44 APE9-dihe-in -60.12, 128.89 APE8-dihe-in -77.82, 67.09 APE8-rot-na 22.6 APE67-dihe-in -76.69, -4.5 -57.03, -26.89 APE12-dist-na 10.016 APE11-dist-na 12.956 APE10-dist-na 9.338 APE9-dist-in 6.64 C936A,Q969A,E971A,K972A,A1016S,C1142A PTR1054 PTR1054 XRAY 2.21 0.194 0.244 A 318 282 8 0 0 2 [[589, 868], [897, 1171]] 2.0 6x8g TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
3LXNA 888 1178 1187.0 MI1:1 Type1 Inactive DFGin 6.778 13.332 ABAminus -117.22, 6.36 -151.94, 138.12 -128.49, 13.86 297.94, 89.56 -49.5, -27.28 in-in in 8.295 Saltbr-in 2.708 HRD-in -87.77, -47.96 70.31, 6.78 in-in-out SNCiio in-out ActLoopNT-in 2.861 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.07, 9.43 APE9-dihe-in -67.55, 131.78 APE8-dihe-in -75.77, 74.58 APE8-rot-na 30.81 APE67-dihe-in -69.79, -1.49 -61.82, -32.12 APE12-dist-na 999.0 APE11-dist-na 12.295 APE10-dist-na 9.049 APE9-dist-in 6.574 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 2.5 0.223 0.286 A 318 288 3 0 0 3 [[589, 868], [897, 1171]] 2.0 3lxn TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
4GJ2A 890 1176 1187.0 0XH:61201 Type1 Inactive DFGin 6.499 13.834 ABAminus -116.66, -15.74 -127.46, 110.18 -105.97, 26.33 294.83, 84.13 -63.08, -27.62 in-in in 8.322 Saltbr-in 2.734 HRD-in -74.66, -47.79 67.89, 7.89 in-in-out SNCiio in-out ActLoopNT-in 2.771 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -86.19, 3.14 APE9-dihe-in -64.72, 133.34 APE8-dihe-in -81.14, 66.53 APE8-rot-na 27.09 APE67-dihe-in -73.52, -3.04 -50.36, -36.27 APE12-dist-na 9.94 APE11-dist-na 13.002 APE10-dist-na 9.497 APE9-dist-in 6.627 C936A,Q969A,E971A,K972A,D1023N,C1142A None None XRAY 2.4 0.198 0.237 A 302 287 0 0 0 0 [[589, 868], [897, 1171]] 2.0 4gj2 TYR_TYK2-2_HUMAN TYR 3.6e-81 278.3 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
4GJ3A 890 1176 1187.0 0XP:61201 Type1 Inactive DFGin 6.788 14.06 ABAminus -95.02, -66.74 -87.4, 118.11 -113.22, 27.63 290.2, 79.54 -63.9, -25.45 in-in in 8.309 Saltbr-in 2.766 HRD-in -79.77, -45.75 65.19, 0.34 in-in-out SNCiio in-out ActLoopNT-in 2.817 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -85.8, 3.66 APE9-dihe-in -66.17, 130.56 APE8-dihe-in -75.94, 67.89 APE8-rot-na 26.78 APE67-dihe-in -71.81, -7.11 -49.81, -38.24 APE12-dist-na 9.928 APE11-dist-na 12.949 APE10-dist-na 9.552 APE9-dist-in 6.595 C936A,Q969A,E971A,K972A,D1023N,C1142A None None XRAY 2.5 0.212 0.26 A 302 287 0 0 0 0 [[589, 868], [897, 1171]] 2.0 4gj3 TYR_TYK2-2_HUMAN TYR 3.6e-81 278.3 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
5WALA 890 1176 1187.0 9ZS:61201 Type1 Inactive DFGin 7.181 13.698 ABAminus -97.25, -15.9 -129.26, 145.58 -139.57, 26.94 290.86, 91.28 -60.49, -34.49 in-in in 8.186 Saltbr-in 2.795 HRD-in -78.43, -50.76 68.0, 1.52 in-in-out SNCiio in-out ActLoopNT-in 2.806 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.25, 6.21 APE9-dihe-in -66.75, 134.63 APE8-dihe-in -82.22, 67.92 APE8-rot-na 22.08 APE67-dihe-in -76.18, -11.03 -54.12, -29.65 APE12-dist-na 9.836 APE11-dist-na 12.919 APE10-dist-na 9.466 APE9-dist-in 6.613 C936A,Q969A,E971A,K972A,D1023N,C1142A None None XRAY 2.45 0.185 0.243 A 302 285 2 0 0 2 [[589, 868], [897, 1171]] 2.0 5wal TYR_TYK2-2_HUMAN TYR 3.6e-81 278.3 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
4GVJA 889 1176 1187.0 ADP:61201 ATPlike Inactive DFGin 6.265 13.752 BLAminus -124.99, -169.67 58.4, 84.34 -100.6, 24.1 294.23, 90.13 -57.35, -28.35 in-in in 8.284 Saltbr-in 2.699 HRD-in -78.85, -48.62 71.47, -0.89 in-in-out SNCiio in-out ActLoopNT-in 2.842 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -90.25, 6.85 APE9-dihe-in -64.48, 128.39 APE8-dihe-in -76.05, 68.17 APE8-rot-na 27.93 APE67-dihe-in -72.65, -6.35 -49.95, -35.24 APE12-dist-na 9.968 APE11-dist-na 13.036 APE10-dist-na 9.649 APE9-dist-in 6.845 C936A,Q969A,E971A,K972A,C1142A None None XRAY 2.03 0.19 0.231 A 302 288 0 0 0 0 [[589, 868], [897, 1171]] 2.0 4gvj TYR_TYK2-2_HUMAN TYR 9.4e-82 280.2 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
4GFOA 890 1176 1187.0 0X2:61206 Type1 Inactive DFGin 6.545 13.815 BLAminus -119.78, -165.53 41.83, 76.86 -90.36, 18.77 286.1, 84.92 -57.97, -31.66 in-out in 8.506 Saltbr-out 3.823 HRD-in -83.33, -51.5 65.48, 12.02 out-in-in SNCoii in-in ActLoopNT-in 2.922 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.28, 60.25 APE9-dihe-in -120.27, 150.37 APE8-dihe-in -75.99, 77.21 APE8-rot-na 30.46 APE67-dihe-in -74.83, -3.18 -56.44, -30.73 APE12-dist-na 11.808 APE11-dist-na 11.275 APE10-dist-na 9.461 APE9-dist-in 5.891 D1023N None None XRAY 2.3 0.237 0.287 A 302 270 17 0 0 0 [[589, 868], [897, 1171]] 2.0 4gfo TYR_TYK2-2_HUMAN TYR 2.2e-81 278.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
3NZ0A 888 1176 1187.0 IZA:60001 Type1 Inactive DFGin 6.154 14.001 BLAminus -133.5, -159.47 28.32, 83.24 -90.11, 26.57 286.27, 82.9 -67.92, -23.72 in-in in 8.384 Saltbr-in 2.664 HRD-in -88.61, -49.58 69.51, 9.87 in-in-out SNCiio in-out ActLoopNT-in 2.841 ActLoopCT-out TYR APEdihe_ioiai APEdist_aaai APE10-dihe-in -125.47, 159.63 APE9-dihe-out -77.1, -98.73 APE8-dihe-in -90.61, 111.37 APE8-rot-na 32.83 APE67-dihe-in -76.56, -4.71 -63.35, -29.86 APE12-dist-na 9.018 APE11-dist-na 9.488 APE10-dist-na 8.885 APE9-dist-in 6.653 D1023N None None XRAY 2.0 0.212 0.253 A 302 283 6 0 0 0 [[589, 868], [897, 1171]] 2.0 3nz0 TYR_TYK2-2_HUMAN TYR 4.9e-81 277.8 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
4GIHA 890 1176 1187.0 0X5:61201 Type1 Inactive DFGin 6.607 13.954 BLAminus -120.14, -171.23 42.64, 89.76 -99.46, 23.47 285.31, 88.12 -62.7, -22.0 in-in in 8.232 Saltbr-in 2.768 HRD-in -83.92, -49.74 70.18, 5.0 in-in-out SNCiio in-out ActLoopNT-in 2.909 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -91.27, -0.22 APE9-dihe-in -61.31, 133.53 APE8-dihe-in -80.65, 66.28 APE8-rot-na 25.35 APE67-dihe-in -75.46, -3.05 -48.32, -34.38 APE12-dist-na 9.887 APE11-dist-na 13.02 APE10-dist-na 9.515 APE9-dist-in 6.707 C936A,Q969A,E971A,K972A,D1023N,C1142A None None XRAY 2.0 0.217 0.217 A 302 287 0 0 0 0 [[589, 868], [897, 1171]] 2.0 4gih TYR_TYK2-2_HUMAN TYR 3.6e-81 278.3 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
3NYXA 889 1176 1187.0 TZ1:60001 Type1.5_Back Inactive DFGin 8.078 15.027 BLAminus -116.4, -161.24 41.9, 77.57 -90.2, 20.12 284.27, 66.62 -58.41, -17.91 out-out out 14.444 Saltbr-out 13.957 HRD-in -91.2, -49.86 72.63, 1.64 out-in-in SNCoii in-in ActLoopNT-in 2.978 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.23, 104.38 APE9-dihe-in -110.21, 141.76 APE8-dihe-in -81.49, 70.84 APE8-rot-na 26.66 APE67-dihe-in -76.53, -3.95 -65.44, -28.59 APE12-dist-na 15.118 APE11-dist-na 11.866 APE10-dist-na 11.062 APE9-dist-in 7.483 D1023N None None XRAY 2.5 0.22 0.275 A 302 285 3 0 0 0 [[589, 868], [897, 1171]] 2.0 3nyx TYR_TYK2-2_HUMAN TYR 2.2e-81 278.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
4GIIA 890 1176 1187.0 0X6:61201 Type1 Inactive DFGin 6.492 13.957 None -81.38, -98.04 -79.43, 140.5 -122.16, 30.13 291.74, 87.83 -62.78, -33.65 in-in in 8.213 Saltbr-in 2.744 HRD-in -76.73, -46.7 63.15, 9.59 in-in-out SNCiio in-out ActLoopNT-in 2.974 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -89.05, 4.42 APE9-dihe-in -63.44, 130.54 APE8-dihe-in -78.88, 64.67 APE8-rot-na 24.5 APE67-dihe-in -75.7, -5.4 -49.65, -33.9 APE12-dist-na 9.905 APE11-dist-na 13.011 APE10-dist-na 9.594 APE9-dist-in 6.657 C936A,Q969A,E971A,K972A,D1023N,C1142A None None XRAY 2.31 0.221 0.252 A 302 287 0 0 0 0 [[589, 868], [897, 1171]] 2.0 4gii TYR_TYK2-2_HUMAN TYR 3.6e-81 278.3 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
7UYSA 890 1177 1187.0 OVC:1201 Type1 None DFGin 6.822 13.649 BLAminus -114.45, -171.35 44.56, 84.78 -101.1, 35.58 297.8, 80.57 -68.2, -34.51 in-in in 8.175 Saltbr-in 2.706 HRD-in -81.8, -57.11 76.46, 1.75 in-in-none SNCiin in-none ActLoopNT-in 2.909 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -43.18 APE9-dihe-in -68.5, 119.8 APE8-dihe-in -75.42, 76.63 APE8-rot-na 32.55 APE67-dihe-in -73.48, -8.09 -58.48, -34.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.841 APE9-dist-in 6.505 None PTR1054,PTR1055 PTR1054,PTR1055 XRAY 2.15 0.232 0.272 A 289 282 6 0 0 4 [[589, 868], [897, 1171]] 2.0 7uys TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
7UYUA 889 1177 1187.0 OV0:1201 Type1 None DFGin 6.732 13.693 BLAminus -116.0, -173.86 46.69, 88.81 -102.3, 31.38 294.59, 76.31 -71.39, -32.91 in-in in 7.837 Saltbr-in 3.038 HRD-in -86.52, -53.34 77.94, 2.86 in-in-none SNCiin in-none ActLoopNT-in 2.911 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.29 APE8-dihe-in -82.32, 79.72 APE8-rot-na 31.91 APE67-dihe-in -72.66, -7.56 -62.66, -28.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.58 None PTR1054,PTR1055 PTR1054,PTR1055 XRAY 2.05 0.227 0.257 A 289 269 20 0 0 7 [[589, 868], [897, 1171]] 2.0 7uyu TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
6AAMA 888 1178 1187.0 9T6:1201 Type1 None DFGin 6.808 13.614 BLAminus -114.96, -166.83 46.97, 77.56 -91.7, 20.81 290.41, 78.57 -55.84, -27.39 in-in in 7.95 Saltbr-in 2.732 HRD-in -93.28, -50.85 70.68, 8.06 in-in-none SNCiin in-none ActLoopNT-in 2.803 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 25.87 APE8-rot-na 15.0 APE67-dihe-in -73.41, -4.27 -60.18, -33.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C936A,Q969A,E971A,K972A,D1023N,I1114L,C1142A None None XRAY 1.98 0.204 0.238 A 298 269 22 0 0 14 [[589, 868], [897, 1171]] 2.0 6aam TYR_TYK2-2_HUMAN TYR 3.4e-81 278.3 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2

TYR_TYK2-2 (Non-receptor tyrosine-protein kinase TYK2)

Total number of chains: 33
Active chains: 7
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 17 51.5% 6DBKA
DFGin BLAminus 15 45.5% AF-P29597-K2A
DFGin None 1 3.0% 4GIIA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYK2_HUMAN AF-P29597-K2A P29597 889 1179 1187.0 No_ligand No_ligand Active DFGin 6.266 13.856 BLAminus -129.16, -172.6 52.17, 81.1 -91.4, 17.41 289.14, 86.02 -61.92, -27.42 in-in in 8.383 Saltbr-in 2.674 HRD-in -70.25, -42.3 64.49, -12.74 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.3, 122.99 APE9-dihe-in -124.95, 133.41 APE8-dihe-in -75.89, 67.63 APE8-rot-na 35.61 APE67-dihe-in -74.56, -10.56 -54.18, -28.6 APE12-dist-na 13.657 APE11-dist-na 9.815 APE10-dist-na 10.236 APE9-dist-in 7.061 None None None AF2 -1.0 1.0 1.0 A 291 291 0 0 0 0 [[589, 868], [897, 1171]] 2.0 AF-P29597-K2 Homo sapiens TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN AF-P29597-K4A P29597 889 1179 1187.0 No_ligand No_ligand Active DFGin 6.336 13.879 BLAminus -129.55, -171.63 53.38, 74.68 -84.95, 17.18 288.9, 80.46 -62.16, -27.19 in-in in 8.326 Saltbr-in 2.659 HRD-in -79.84, -43.53 59.12, -2.49 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -59.44, 131.09 APE9-dihe-in -129.28, 129.49 APE8-dihe-in -73.84, 63.43 APE8-rot-na 35.77 APE67-dihe-in -74.2, -11.8 -53.93, -29.14 APE12-dist-na 12.864 APE11-dist-na 9.455 APE10-dist-na 9.489 APE9-dist-in 6.739 None None None AF2 -1.0 1.0 1.0 A 291 291 0 0 0 0 [[589, 868], [897, 1171]] 2.0 AF-P29597-K4 Homo sapiens TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 7UYTA P29597 890 1177 1187.0 OV5:1201 Type1 Active DFGin 6.6 13.563 BLAminus -113.96, -166.72 43.12, 92.69 -104.69, 31.01 290.99, 83.76 -63.14, -33.25 in-in in 7.554 Saltbr-in 3.173 HRD-in -84.86, -57.24 78.5, -1.23 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.23, 72.86 APE9-dihe-in -74.56, 127.74 APE8-dihe-in -83.18, 74.68 APE8-rot-na 37.06 APE67-dihe-in -71.62, -8.97 -55.74, -33.87 APE12-dist-na 12.592 APE11-dist-na 9.028 APE10-dist-na 9.2 APE9-dist-in 6.489 None PTR1054,PTR1055 PTR1054,PTR1055 XRAY 2.14 0.245 0.293 A 289 278 10 0 0 2 [[589, 868], [897, 1171]] 2.0 7uyt Homo sapiens TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 3LXPA P29597 888 1178 1187.0 IZA:1183 Type1 Active DFGin 6.516 14.068 BLAminus -125.49, -162.27 32.56, 69.7 -75.76, 18.49 286.14, 89.4 -52.16, -34.42 in-in in 8.353 Saltbr-in 2.576 HRD-in -85.74, -50.8 74.46, 2.83 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -90.42, 114.17 APE9-dihe-in -102.81, 153.1 APE8-dihe-in -78.99, 64.19 APE8-rot-na 29.2 APE67-dihe-in -72.53, -2.22 -56.28, -30.53 APE12-dist-na 999.0 APE11-dist-na 10.927 APE10-dist-na 11.281 APE9-dist-in 6.778 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 1.65 0.194 0.229 A 318 286 5 0 0 3 [[589, 868], [897, 1171]] 2.0 3lxp Homo sapiens TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 5F1ZA P29597 886 1176 1187.0 5U3:61200 Type1 Active DFGin 6.206 13.956 BLAminus -129.2, -165.99 40.61, 85.28 -97.37, 33.45 284.09, 63.85 -64.96, -27.88 in-in in 7.536 Saltbr-in 3.04 HRD-in -91.41, -43.93 63.21, 17.11 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.48, 145.93 APE9-dihe-in -146.94, 155.61 APE8-dihe-in -74.89, 73.59 APE8-rot-na 30.25 APE67-dihe-in -77.49, 3.7 -64.13, -25.53 APE12-dist-na 12.687 APE11-dist-na 11.388 APE10-dist-na 11.106 APE9-dist-in 6.587 None None None XRAY 2.65 0.22 0.31 A 301 280 11 0 0 0 [[589, 868], [897, 1171]] 2.0 5f1z Homo sapiens TYR_TYK2-2_HUMAN TYR 2.2e-81 279.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 5F20A P29597 888 1176 1187.0 5U4:1200 Type1 Active DFGin 6.403 13.645 BLAminus -113.81, -158.54 31.35, 78.87 -88.8, 21.81 284.42, 71.86 -44.97, -45.07 in-in in 7.343 Saltbr-in 3.308 HRD-in -78.86, -34.24 65.78, -0.57 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.24, 144.87 APE9-dihe-in -130.77, 139.79 APE8-dihe-in -66.89, 65.4 APE8-rot-na 26.96 APE67-dihe-in -83.29, -2.83 -63.91, -21.29 APE12-dist-na 11.279 APE11-dist-na 11.394 APE10-dist-na 11.008 APE9-dist-in 7.023 None None None XRAY 2.91 0.205 0.288 A 301 274 15 0 0 0 [[589, 868], [897, 1171]] 2.0 5f20 Homo sapiens TYR_TYK2-2_HUMAN TYR 2.2e-81 279.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6OVAA P29597 888 1175 1187.0 N9G:1200 Type1 Active DFGin 6.351 13.943 BLAminus -130.49, -167.36 38.71, 89.63 -96.32, 19.31 284.72, 70.82 -52.83, -28.66 in-in in 7.822 Saltbr-in 2.787 HRD-in -92.56, -54.5 71.46, 13.79 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.41, 141.23 APE9-dihe-in -150.02, 159.37 APE8-dihe-in -76.58, 70.53 APE8-rot-na 23.86 APE67-dihe-in -75.33, -2.58 -60.5, -26.47 APE12-dist-na 12.05 APE11-dist-na 11.277 APE10-dist-na 11.033 APE9-dist-in 6.377 None None None XRAY 2.5 0.2 0.251 A 301 273 15 0 0 0 [[589, 868], [897, 1171]] 2.0 6ova Homo sapiens TYR_TYK2-2_HUMAN TYR 2.2e-81 279.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 7UYRA P29597 890 1177 1187.0 OVI:1201 Type1 Inactive DFGin 6.893 13.575 ABAminus -115.92, -24.42 -138.27, 134.13 -131.63, 30.54 291.7, 86.26 -68.73, -29.22 in-out in 7.844 Saltbr-out 4.253 HRD-in -84.33, -53.98 75.58, 8.54 out-in-none SNCoin in-none ActLoopNT-in 2.808 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -62.06 APE9-dihe-in -73.92, 136.51 APE8-dihe-in -78.67, 70.61 APE8-rot-na 29.09 APE67-dihe-in -73.97, -8.9 -61.21, -30.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.808 APE9-dist-in 6.71 None PTR1054,PTR1055 PTR1054,PTR1055 XRAY 2.15 0.205 0.259 A 289 282 6 0 0 6 [[589, 868], [897, 1171]] 2.0 7uyr Homo sapiens TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 4PY1A P29597 889 1178 1187.0 2YK:1201 Type1 Inactive DFGin 6.893 13.579 ABAminus -113.0, -22.09 -124.57, 117.57 -104.94, 28.18 290.62, 81.68 -57.39, -32.81 in-in in 8.377 Saltbr-in 2.741 HRD-in -78.12, -49.58 73.18, -2.6 in-in-out SNCiio in-out ActLoopNT-in 2.796 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -99.39, 3.55 APE9-dihe-in -62.33, 127.2 APE8-dihe-in -77.67, 66.69 APE8-rot-na 30.36 APE67-dihe-in -75.63, -5.27 -51.36, -32.2 APE12-dist-na 10.374 APE11-dist-na 13.139 APE10-dist-na 9.565 APE9-dist-in 6.864 C936A,Q969A,E971A,K972A,A1016S,C1142A PTR1054 PTR1054 XRAY 2.16 0.184 0.236 A 318 290 0 0 0 0 [[589, 868], [897, 1171]] 2.0 4py1 Homo sapiens TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6DBKA P29597 889 1178 1187.0 G5D:4000 Type1 Inactive DFGin 6.754 13.312 ABAminus -108.33, 3.25 -147.57, 142.28 -132.84, 28.54 296.5, 85.96 -50.88, -35.67 in-in in 8.37 Saltbr-in 2.75 HRD-in -80.67, -52.64 72.46, -2.15 in-in-out SNCiio in-out ActLoopNT-in 2.866 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -99.35, 0.82 APE9-dihe-in -54.67, 132.67 APE8-dihe-in -80.05, 71.48 APE8-rot-na 29.23 APE67-dihe-in -72.51, -5.27 -51.63, -35.72 APE12-dist-na 10.052 APE11-dist-na 13.16 APE10-dist-na 10.012 APE9-dist-in 6.734 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 2.0 0.203 0.249 A 318 290 0 0 0 0 [[589, 868], [897, 1171]] 2.0 6dbk Homo sapiens TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6DBMA P29597 889 1178 1187.0 G4J:4000 Type1 Inactive DFGin 6.402 13.381 ABAminus -104.02, 1.7 -152.49, 145.86 -137.95, 42.02 302.25, 86.41 -67.57, -26.89 in-in in 8.851 Saltbr-in 2.699 HRD-in -93.72, -57.81 77.91, 10.17 in-in-out SNCiio in-out ActLoopNT-in 2.869 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -82.24, 0.6 APE9-dihe-in -73.63, 132.77 APE8-dihe-in -74.36, 72.39 APE8-rot-na 28.5 APE67-dihe-in -74.28, -1.08 -60.7, -31.84 APE12-dist-na 10.078 APE11-dist-na 13.186 APE10-dist-na 9.685 APE9-dist-in 6.421 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 2.368 0.204 0.264 A 318 274 16 0 0 3 [[589, 868], [897, 1171]] 2.0 6dbm Homo sapiens TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6VNSA P29597 889 1178 1187.0 R5D:4000 Type1 Inactive DFGin 6.658 13.506 ABAminus -108.04, 9.42 -153.13, 141.48 -134.56, 31.14 297.55, 90.4 -55.34, -27.89 in-in in 8.392 Saltbr-in 2.759 HRD-in -80.98, -51.2 72.5, -3.91 in-in-out SNCiio in-out ActLoopNT-in 2.946 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -93.89, 0.93 APE9-dihe-in -68.47, 124.35 APE8-dihe-in -77.47, 69.41 APE8-rot-na 29.48 APE67-dihe-in -77.69, -3.72 -52.06, -30.79 APE12-dist-na 10.45 APE11-dist-na 13.118 APE10-dist-na 9.228 APE9-dist-in 6.757 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 2.09 0.188 0.231 A 318 290 0 0 0 0 [[589, 868], [897, 1171]] 2.0 6vns Homo sapiens TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6VNVA P29597 889 1178 1187.0 R4Y:4000 Type1 Inactive DFGin 6.346 13.404 ABAminus -109.84, 1.0 -145.58, 142.68 -134.32, 29.59 295.91, 88.64 -55.43, -34.03 in-in in 8.342 Saltbr-in 2.751 HRD-in -83.86, -49.18 65.87, 7.87 in-in-out SNCiio in-out ActLoopNT-in 2.903 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.02, 18.68 APE9-dihe-in -71.67, 138.4 APE8-dihe-in -78.48, 67.28 APE8-rot-na 26.2 APE67-dihe-in -77.83, -5.33 -55.89, -29.32 APE12-dist-na 9.804 APE11-dist-na 13.241 APE10-dist-na 10.029 APE9-dist-in 6.585 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 2.15 0.189 0.238 A 318 275 15 0 0 0 [[589, 868], [897, 1171]] 2.0 6vnv Homo sapiens TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6VNXA P29597 889 1178 1187.0 R4V:4000 Type1 Inactive DFGin 6.778 13.489 ABAminus -107.68, 5.81 -147.51, 139.03 -132.77, 32.03 296.4, 87.46 -59.82, -29.87 in-in in 8.48 Saltbr-in 2.845 HRD-in -78.78, -53.6 74.67, -1.35 in-in-out SNCiio in-out ActLoopNT-in 2.8 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -93.13, 2.52 APE9-dihe-in -67.17, 125.69 APE8-dihe-in -78.92, 68.35 APE8-rot-na 29.46 APE67-dihe-in -78.75, -0.47 -50.92, -34.17 APE12-dist-na 10.71 APE11-dist-na 13.129 APE10-dist-na 9.408 APE9-dist-in 6.782 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 2.18 0.196 0.238 A 318 290 0 0 0 0 [[589, 868], [897, 1171]] 2.0 6vnx Homo sapiens TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6VNYA P29597 889 1178 1187.0 R4S:4000 Type1 Inactive DFGin 6.71 13.642 ABAminus -108.42, 4.15 -147.63, 142.15 -133.65, 30.43 294.62, 90.13 -52.87, -33.85 in-in in 8.231 Saltbr-in 2.778 HRD-in -77.71, -50.71 72.39, -6.46 in-in-out SNCiio in-out ActLoopNT-in 2.81 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -94.29, 3.77 APE9-dihe-in -73.55, 133.09 APE8-dihe-in -79.53, 66.39 APE8-rot-na 27.75 APE67-dihe-in -77.39, 0.21 -51.74, -32.37 APE12-dist-na 10.406 APE11-dist-na 13.35 APE10-dist-na 9.706 APE9-dist-in 6.771 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 2.3 0.176 0.229 A 318 287 3 0 0 3 [[589, 868], [897, 1171]] 2.0 6vny Homo sapiens TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6X8FA P29597 889 1178 1187.0 UWP:4001 Type1 Inactive DFGin 6.368 13.443 ABAminus -95.56, -18.62 -136.08, 142.25 -132.97, 38.39 300.79, 80.69 -60.74, -30.23 in-in in 8.59 Saltbr-in 2.814 HRD-in -80.09, -50.24 67.91, 4.2 in-in-out SNCiio in-out ActLoopNT-in 2.813 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -85.77, 10.94 APE9-dihe-in -74.28, 130.62 APE8-dihe-in -82.04, 69.42 APE8-rot-na 28.67 APE67-dihe-in -81.13, -2.61 -51.22, -29.34 APE12-dist-na 9.813 APE11-dist-na 12.675 APE10-dist-na 9.193 APE9-dist-in 6.525 C936A,Q969A,E971A,K972A,A1016S,C1142A PTR1054 PTR1054 XRAY 2.15 0.208 0.255 A 318 283 7 0 0 0 [[589, 868], [897, 1171]] 2.0 6x8f Homo sapiens TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6X8FC P29597 889 1178 1187.0 UWP:4000 Type1 Inactive DFGin 6.411 13.467 ABAminus -95.34, -17.32 -136.72, 141.32 -133.98, 37.29 300.65, 80.99 -60.17, -32.21 in-in in 8.489 Saltbr-in 2.696 HRD-in -78.97, -50.37 67.86, 4.05 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -92.16, 9.73 APE9-dihe-in -74.69, 130.77 APE8-dihe-in -82.29, 70.3 APE8-rot-na 28.25 APE67-dihe-in -80.62, -2.35 -52.14, -29.87 APE12-dist-na 10.892 APE11-dist-na 12.859 APE10-dist-na 9.189 APE9-dist-in 6.55 C936A,Q969A,E971A,K972A,A1016S,C1142A PTR1054 PTR1054 XRAY 2.15 0.208 0.255 C 318 290 0 0 0 0 [[589, 868], [897, 1171]] 2.0 6x8f Homo sapiens TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6X8GA P29597 889 1178 1187.0 UWM:4000 Type1 Inactive DFGin 6.36 13.409 ABAminus -102.36, -12.35 -141.17, 141.98 -131.51, 29.12 299.29, 85.37 -56.7, -31.51 in-in in 8.753 Saltbr-in 2.795 HRD-in -84.67, -51.08 70.92, -1.88 in-in-out SNCiio in-out ActLoopNT-in 2.834 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -92.94, 4.44 APE9-dihe-in -60.12, 128.89 APE8-dihe-in -77.82, 67.09 APE8-rot-na 22.6 APE67-dihe-in -76.69, -4.5 -57.03, -26.89 APE12-dist-na 10.016 APE11-dist-na 12.956 APE10-dist-na 9.338 APE9-dist-in 6.64 C936A,Q969A,E971A,K972A,A1016S,C1142A PTR1054 PTR1054 XRAY 2.21 0.194 0.244 A 318 282 8 0 0 2 [[589, 868], [897, 1171]] 2.0 6x8g Homo sapiens TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 3LXNA P29597 888 1178 1187.0 MI1:1 Type1 Inactive DFGin 6.778 13.332 ABAminus -117.22, 6.36 -151.94, 138.12 -128.49, 13.86 297.94, 89.56 -49.5, -27.28 in-in in 8.295 Saltbr-in 2.708 HRD-in -87.77, -47.96 70.31, 6.78 in-in-out SNCiio in-out ActLoopNT-in 2.861 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.07, 9.43 APE9-dihe-in -67.55, 131.78 APE8-dihe-in -75.77, 74.58 APE8-rot-na 30.81 APE67-dihe-in -69.79, -1.49 -61.82, -32.12 APE12-dist-na 999.0 APE11-dist-na 12.295 APE10-dist-na 9.049 APE9-dist-in 6.574 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 2.5 0.223 0.286 A 318 288 3 0 0 3 [[589, 868], [897, 1171]] 2.0 3lxn Homo sapiens TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 4GJ2A P29597 890 1176 1187.0 0XH:61201 Type1 Inactive DFGin 6.499 13.834 ABAminus -116.66, -15.74 -127.46, 110.18 -105.97, 26.33 294.83, 84.13 -63.08, -27.62 in-in in 8.322 Saltbr-in 2.734 HRD-in -74.66, -47.79 67.89, 7.89 in-in-out SNCiio in-out ActLoopNT-in 2.771 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -86.19, 3.14 APE9-dihe-in -64.72, 133.34 APE8-dihe-in -81.14, 66.53 APE8-rot-na 27.09 APE67-dihe-in -73.52, -3.04 -50.36, -36.27 APE12-dist-na 9.94 APE11-dist-na 13.002 APE10-dist-na 9.497 APE9-dist-in 6.627 C936A,Q969A,E971A,K972A,D1023N,C1142A None None XRAY 2.4 0.198 0.237 A 302 287 0 0 0 0 [[589, 868], [897, 1171]] 2.0 4gj2 Homo sapiens TYR_TYK2-2_HUMAN TYR 3.6e-81 278.3 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 4GJ3A P29597 890 1176 1187.0 0XP:61201 Type1 Inactive DFGin 6.788 14.06 ABAminus -95.02, -66.74 -87.4, 118.11 -113.22, 27.63 290.2, 79.54 -63.9, -25.45 in-in in 8.309 Saltbr-in 2.766 HRD-in -79.77, -45.75 65.19, 0.34 in-in-out SNCiio in-out ActLoopNT-in 2.817 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -85.8, 3.66 APE9-dihe-in -66.17, 130.56 APE8-dihe-in -75.94, 67.89 APE8-rot-na 26.78 APE67-dihe-in -71.81, -7.11 -49.81, -38.24 APE12-dist-na 9.928 APE11-dist-na 12.949 APE10-dist-na 9.552 APE9-dist-in 6.595 C936A,Q969A,E971A,K972A,D1023N,C1142A None None XRAY 2.5 0.212 0.26 A 302 287 0 0 0 0 [[589, 868], [897, 1171]] 2.0 4gj3 Homo sapiens TYR_TYK2-2_HUMAN TYR 3.6e-81 278.3 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 5WALA P29597 890 1176 1187.0 9ZS:61201 Type1 Inactive DFGin 7.181 13.698 ABAminus -97.25, -15.9 -129.26, 145.58 -139.57, 26.94 290.86, 91.28 -60.49, -34.49 in-in in 8.186 Saltbr-in 2.795 HRD-in -78.43, -50.76 68.0, 1.52 in-in-out SNCiio in-out ActLoopNT-in 2.806 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.25, 6.21 APE9-dihe-in -66.75, 134.63 APE8-dihe-in -82.22, 67.92 APE8-rot-na 22.08 APE67-dihe-in -76.18, -11.03 -54.12, -29.65 APE12-dist-na 9.836 APE11-dist-na 12.919 APE10-dist-na 9.466 APE9-dist-in 6.613 C936A,Q969A,E971A,K972A,D1023N,C1142A None None XRAY 2.45 0.185 0.243 A 302 285 2 0 0 2 [[589, 868], [897, 1171]] 2.0 5wal Homo sapiens TYR_TYK2-2_HUMAN TYR 3.6e-81 278.3 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 4GVJA P29597 889 1176 1187.0 ADP:61201 ATPlike Inactive DFGin 6.265 13.752 BLAminus -124.99, -169.67 58.4, 84.34 -100.6, 24.1 294.23, 90.13 -57.35, -28.35 in-in in 8.284 Saltbr-in 2.699 HRD-in -78.85, -48.62 71.47, -0.89 in-in-out SNCiio in-out ActLoopNT-in 2.842 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -90.25, 6.85 APE9-dihe-in -64.48, 128.39 APE8-dihe-in -76.05, 68.17 APE8-rot-na 27.93 APE67-dihe-in -72.65, -6.35 -49.95, -35.24 APE12-dist-na 9.968 APE11-dist-na 13.036 APE10-dist-na 9.649 APE9-dist-in 6.845 C936A,Q969A,E971A,K972A,C1142A None None XRAY 2.03 0.19 0.231 A 302 288 0 0 0 0 [[589, 868], [897, 1171]] 2.0 4gvj Homo sapiens TYR_TYK2-2_HUMAN TYR 9.4e-82 280.2 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 4GFOA P29597 890 1176 1187.0 0X2:61206 Type1 Inactive DFGin 6.545 13.815 BLAminus -119.78, -165.53 41.83, 76.86 -90.36, 18.77 286.1, 84.92 -57.97, -31.66 in-out in 8.506 Saltbr-out 3.823 HRD-in -83.33, -51.5 65.48, 12.02 out-in-in SNCoii in-in ActLoopNT-in 2.922 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.28, 60.25 APE9-dihe-in -120.27, 150.37 APE8-dihe-in -75.99, 77.21 APE8-rot-na 30.46 APE67-dihe-in -74.83, -3.18 -56.44, -30.73 APE12-dist-na 11.808 APE11-dist-na 11.275 APE10-dist-na 9.461 APE9-dist-in 5.891 D1023N None None XRAY 2.3 0.237 0.287 A 302 270 17 0 0 0 [[589, 868], [897, 1171]] 2.0 4gfo Homo sapiens TYR_TYK2-2_HUMAN TYR 2.2e-81 278.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 3NZ0A P29597 888 1176 1187.0 IZA:60001 Type1 Inactive DFGin 6.154 14.001 BLAminus -133.5, -159.47 28.32, 83.24 -90.11, 26.57 286.27, 82.9 -67.92, -23.72 in-in in 8.384 Saltbr-in 2.664 HRD-in -88.61, -49.58 69.51, 9.87 in-in-out SNCiio in-out ActLoopNT-in 2.841 ActLoopCT-out TYR APEdihe_ioiai APEdist_aaai APE10-dihe-in -125.47, 159.63 APE9-dihe-out -77.1, -98.73 APE8-dihe-in -90.61, 111.37 APE8-rot-na 32.83 APE67-dihe-in -76.56, -4.71 -63.35, -29.86 APE12-dist-na 9.018 APE11-dist-na 9.488 APE10-dist-na 8.885 APE9-dist-in 6.653 D1023N None None XRAY 2.0 0.212 0.253 A 302 283 6 0 0 0 [[589, 868], [897, 1171]] 2.0 3nz0 Homo sapiens TYR_TYK2-2_HUMAN TYR 4.9e-81 277.8 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 4GIHA P29597 890 1176 1187.0 0X5:61201 Type1 Inactive DFGin 6.607 13.954 BLAminus -120.14, -171.23 42.64, 89.76 -99.46, 23.47 285.31, 88.12 -62.7, -22.0 in-in in 8.232 Saltbr-in 2.768 HRD-in -83.92, -49.74 70.18, 5.0 in-in-out SNCiio in-out ActLoopNT-in 2.909 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -91.27, -0.22 APE9-dihe-in -61.31, 133.53 APE8-dihe-in -80.65, 66.28 APE8-rot-na 25.35 APE67-dihe-in -75.46, -3.05 -48.32, -34.38 APE12-dist-na 9.887 APE11-dist-na 13.02 APE10-dist-na 9.515 APE9-dist-in 6.707 C936A,Q969A,E971A,K972A,D1023N,C1142A None None XRAY 2.0 0.217 0.217 A 302 287 0 0 0 0 [[589, 868], [897, 1171]] 2.0 4gih Homo sapiens TYR_TYK2-2_HUMAN TYR 3.6e-81 278.3 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 3NYXA P29597 889 1176 1187.0 TZ1:60001 Type1.5_Back Inactive DFGin 8.078 15.027 BLAminus -116.4, -161.24 41.9, 77.57 -90.2, 20.12 284.27, 66.62 -58.41, -17.91 out-out out 14.444 Saltbr-out 13.957 HRD-in -91.2, -49.86 72.63, 1.64 out-in-in SNCoii in-in ActLoopNT-in 2.978 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.23, 104.38 APE9-dihe-in -110.21, 141.76 APE8-dihe-in -81.49, 70.84 APE8-rot-na 26.66 APE67-dihe-in -76.53, -3.95 -65.44, -28.59 APE12-dist-na 15.118 APE11-dist-na 11.866 APE10-dist-na 11.062 APE9-dist-in 7.483 D1023N None None XRAY 2.5 0.22 0.275 A 302 285 3 0 0 0 [[589, 868], [897, 1171]] 2.0 3nyx Homo sapiens TYR_TYK2-2_HUMAN TYR 2.2e-81 278.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 4GIIA P29597 890 1176 1187.0 0X6:61201 Type1 Inactive DFGin 6.492 13.957 None -81.38, -98.04 -79.43, 140.5 -122.16, 30.13 291.74, 87.83 -62.78, -33.65 in-in in 8.213 Saltbr-in 2.744 HRD-in -76.73, -46.7 63.15, 9.59 in-in-out SNCiio in-out ActLoopNT-in 2.974 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -89.05, 4.42 APE9-dihe-in -63.44, 130.54 APE8-dihe-in -78.88, 64.67 APE8-rot-na 24.5 APE67-dihe-in -75.7, -5.4 -49.65, -33.9 APE12-dist-na 9.905 APE11-dist-na 13.011 APE10-dist-na 9.594 APE9-dist-in 6.657 C936A,Q969A,E971A,K972A,D1023N,C1142A None None XRAY 2.31 0.221 0.252 A 302 287 0 0 0 0 [[589, 868], [897, 1171]] 2.0 4gii Homo sapiens TYR_TYK2-2_HUMAN TYR 3.6e-81 278.3 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 7UYSA P29597 890 1177 1187.0 OVC:1201 Type1 None DFGin 6.822 13.649 BLAminus -114.45, -171.35 44.56, 84.78 -101.1, 35.58 297.8, 80.57 -68.2, -34.51 in-in in 8.175 Saltbr-in 2.706 HRD-in -81.8, -57.11 76.46, 1.75 in-in-none SNCiin in-none ActLoopNT-in 2.909 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -43.18 APE9-dihe-in -68.5, 119.8 APE8-dihe-in -75.42, 76.63 APE8-rot-na 32.55 APE67-dihe-in -73.48, -8.09 -58.48, -34.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.841 APE9-dist-in 6.505 None PTR1054,PTR1055 PTR1054,PTR1055 XRAY 2.15 0.232 0.272 A 289 282 6 0 0 4 [[589, 868], [897, 1171]] 2.0 7uys Homo sapiens TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 7UYUA P29597 889 1177 1187.0 OV0:1201 Type1 None DFGin 6.732 13.693 BLAminus -116.0, -173.86 46.69, 88.81 -102.3, 31.38 294.59, 76.31 -71.39, -32.91 in-in in 7.837 Saltbr-in 3.038 HRD-in -86.52, -53.34 77.94, 2.86 in-in-none SNCiin in-none ActLoopNT-in 2.911 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.29 APE8-dihe-in -82.32, 79.72 APE8-rot-na 31.91 APE67-dihe-in -72.66, -7.56 -62.66, -28.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.58 None PTR1054,PTR1055 PTR1054,PTR1055 XRAY 2.05 0.227 0.257 A 289 269 20 0 0 7 [[589, 868], [897, 1171]] 2.0 7uyu Homo sapiens TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6AAMA P29597 888 1178 1187.0 9T6:1201 Type1 None DFGin 6.808 13.614 BLAminus -114.96, -166.83 46.97, 77.56 -91.7, 20.81 290.41, 78.57 -55.84, -27.39 in-in in 7.95 Saltbr-in 2.732 HRD-in -93.28, -50.85 70.68, 8.06 in-in-none SNCiin in-none ActLoopNT-in 2.803 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 25.87 APE8-rot-na 15.0 APE67-dihe-in -73.41, -4.27 -60.18, -33.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C936A,Q969A,E971A,K972A,D1023N,I1114L,C1142A None None XRAY 1.98 0.204 0.238 A 298 269 22 0 0 14 [[589, 868], [897, 1171]] 2.0 6aam Homo sapiens TYR_TYK2-2_HUMAN TYR 3.4e-81 278.3 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYK2_MOUSE 4E20A Q9R117 885 1174 1184.0 0MY:61201 Type1 Inactive DFGin 6.692 13.768 ABAminus -104.75, -15.26 -138.64, 136.24 -124.57, 23.08 294.22, 84.07 -47.61, -38.48 in-in in 8.681 Saltbr-in 2.943 HRD-in -82.58, -52.8 75.27, -4.02 in-in-out SNCiio in-out ActLoopNT-in 3.022 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -94.07, -17.47 APE9-dihe-in -62.54, 143.43 APE8-dihe-in -73.58, 81.51 APE8-rot-na 29.38 APE67-dihe-in -77.37, -6.91 -58.23, -39.6 APE12-dist-na 10.22 APE11-dist-na 13.765 APE10-dist-na 10.462 APE9-dist-in 6.729 D1020A None None XRAY 2.6 0.2 0.233 A 290 282 8 0 0 0 [[589, 865], [894, 1168]] 2.0 4e20 Mus musculus TYR_TYK2-2_MOUSE TYR 3.3e-81 278.4 2 260 259 1037 1038 1039 1041 1043 927 944 948 1017 1019 1018 1020 1080 1068 1063 1062 1061 1060 1059 1058 1057 976 Non-receptor tyrosine-protein kinase TYK2
TYK2_MOUSE 4E1ZA Q9R117 884 1174 1184.0 0MX:61201 Type1 Inactive DFGin 6.65 13.701 ABAminus -108.69, -5.13 -140.55, 134.21 -128.91, 26.37 294.24, 85.21 -59.36, -29.91 in-in in 8.565 Saltbr-in 2.869 HRD-in -93.23, -51.45 71.55, -3.71 in-in-out SNCiio in-out ActLoopNT-in 2.981 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.09, -28.21 APE9-dihe-in -72.65, 167.72 APE8-dihe-in -69.37, 69.51 APE8-rot-na 27.44 APE67-dihe-in -73.41, 0.57 -61.61, -34.84 APE12-dist-na 10.321 APE11-dist-na 13.846 APE10-dist-na 11.736 APE9-dist-in 6.488 D1020A None None XRAY 2.5 0.199 0.237 A 291 288 3 0 0 0 [[589, 865], [894, 1168]] 2.0 4e1z Mus musculus TYR_TYK2-2_MOUSE TYR 3.3e-81 278.3 2 260 259 1037 1038 1039 1041 1043 927 944 948 1017 1019 1018 1020 1080 1068 1063 1062 1061 1060 1059 1058 1057 976 Non-receptor tyrosine-protein kinase TYK2

TYR_TYK2-2 (Non-receptor tyrosine-protein kinase TYK2)

Total number of chains: 2
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 4E1ZA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYK2_MOUSE 4E20A Q9R117 885 1174 1184.0 0MY:61201 Type1 Inactive DFGin 6.692 13.768 ABAminus -104.75, -15.26 -138.64, 136.24 -124.57, 23.08 294.22, 84.07 -47.61, -38.48 in-in in 8.681 Saltbr-in 2.943 HRD-in -82.58, -52.8 75.27, -4.02 in-in-out SNCiio in-out ActLoopNT-in 3.022 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -94.07, -17.47 APE9-dihe-in -62.54, 143.43 APE8-dihe-in -73.58, 81.51 APE8-rot-na 29.38 APE67-dihe-in -77.37, -6.91 -58.23, -39.6 APE12-dist-na 10.22 APE11-dist-na 13.765 APE10-dist-na 10.462 APE9-dist-in 6.729 D1020A None None XRAY 2.6 0.2 0.233 A 290 282 8 0 0 0 [[589, 865], [894, 1168]] 2.0 4e20 Mus musculus TYR_TYK2-2_MOUSE TYR 3.3e-81 278.4 2 260 259 1037 1038 1039 1041 1043 927 944 948 1017 1019 1018 1020 1080 1068 1063 1062 1061 1060 1059 1058 1057 976 Non-receptor tyrosine-protein kinase TYK2
TYK2_MOUSE 4E1ZA Q9R117 884 1174 1184.0 0MX:61201 Type1 Inactive DFGin 6.65 13.701 ABAminus -108.69, -5.13 -140.55, 134.21 -128.91, 26.37 294.24, 85.21 -59.36, -29.91 in-in in 8.565 Saltbr-in 2.869 HRD-in -93.23, -51.45 71.55, -3.71 in-in-out SNCiio in-out ActLoopNT-in 2.981 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.09, -28.21 APE9-dihe-in -72.65, 167.72 APE8-dihe-in -69.37, 69.51 APE8-rot-na 27.44 APE67-dihe-in -73.41, 0.57 -61.61, -34.84 APE12-dist-na 10.321 APE11-dist-na 13.846 APE10-dist-na 11.736 APE9-dist-in 6.488 D1020A None None XRAY 2.5 0.199 0.237 A 291 288 3 0 0 0 [[589, 865], [894, 1168]] 2.0 4e1z Mus musculus TYR_TYK2-2_MOUSE TYR 3.3e-81 278.3 2 260 259 1037 1038 1039 1041 1043 927 944 948 1017 1019 1018 1020 1080 1068 1063 1062 1061 1060 1059 1058 1057 976 Non-receptor tyrosine-protein kinase TYK2