TYR_SYK (Tyrosine-protein kinase SYK)

Total number of chains: 103
Active chains: 36
Uniprot: KSYK_HUMAN
Kinase Domain Residues: 370 - 628
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 98 95.1% AF-P43405-K1A
DFGin BLBplus 3 2.9% 4FL2A
DFGout BBAminus 1 1.0% 3TUBA
DFGout None 1 1.0% 3TUDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
4FL1A 1.79 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 363 - 635 0 None None Tyrosine-protein kinase SYK
AF-P43405-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 362 - 635 0 None None Tyrosine-protein kinase SYK
AF-P43405-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 362 - 635 0 None None Tyrosine-protein kinase SYK
1XBAA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 363 - 635 0 None None Tyrosine-protein kinase SYK
4F4PA 2.37 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0SB Type1 365 - 635 0 None None Tyrosine-protein kinase SYK
4DFNA 2.48 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0K1 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
4PV0A 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai CG4 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
6HM6A 2.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai GDK Type1 364 - 632 0 PTR525 None Tyrosine-protein kinase SYK
3SRVA 1.95 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai S19 Type1 364 - 634 0 PTR525 None Tyrosine-protein kinase SYK
3SRVB 1.95 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai S19 Type1 364 - 632 0 None None Tyrosine-protein kinase SYK
5LMAA 1.43 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6ZG Type1 363 - 632 0 PTR525 None Tyrosine-protein kinase SYK
5LMBA 1.95 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6ZF Type1 364 - 634 0 PTR525 None Tyrosine-protein kinase SYK
6VOVB 1.95 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R6D Type1 364 - 633 0 None None Tyrosine-protein kinase SYK
4YJOA 1.6 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 4DF Type1 363 - 632 0 None None Tyrosine-protein kinase SYK
4YJPA 1.83 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 4DL Type1 364 - 632 0 None None Tyrosine-protein kinase SYK
4YJSA 2.22 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 4DN Type1 364 - 632 0 None None Tyrosine-protein kinase SYK
8RRQA 1.6 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai A1H2W Type1 363 - 632 0 PTR525,PTR526 None Tyrosine-protein kinase SYK
5TT7A 1.77 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 7KF Type1 358 - 635 0 None None Tyrosine-protein kinase SYK
8XQ0A 1.95 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai A1LV4 Type1 364 - 634 0 None None Tyrosine-protein kinase SYK
8XQ0C 1.95 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai A1LV4 Type1 364 - 633 0 None None Tyrosine-protein kinase SYK
1XBCA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
3FQHA 2.26 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 057 Type1 363 - 634 0 None None Tyrosine-protein kinase SYK
4GFGA 2.35 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0XF Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
5TIUA 1.49 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 7CU Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
5Y5TA 1.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 8OR Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
5Y5UA 2.14 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 8OU Type1 364 - 634 0 None None Tyrosine-protein kinase SYK
4WNMA 2.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3RT Type1 347 - 635 0 None None Tyrosine-protein kinase SYK
5C26A 1.95 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 50H Type1 363 - 635 0 PTR525,PTR526 None Tyrosine-protein kinase SYK
5C27A 2.15 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 50J Type1 363 - 635 0 PTR525,PTR526 None Tyrosine-protein kinase SYK
6ZC0A 1.97 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai QDZ Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
6ZCPA 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai QFK Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
4RX7A 1.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3YV Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
4RX8A 1.59 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3YX Type1 364 - 635 0 None None Tyrosine-protein kinase SYK
5CXHA 1.9 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 55M Type1 363 - 635 0 None K467T Tyrosine-protein kinase SYK
4RX9A 1.75 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3YT Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
5CY3A 1.76 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 55Y Type1 360 - 635 0 None K467T Tyrosine-protein kinase SYK
4DFLA 1.98 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0K0 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
4YJQA 1.34 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai 4DK Type1 364 - 633 0 PTR525,PTR526 None Tyrosine-protein kinase SYK
4YJRA 1.32 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai 4DJ Type1 364 - 633 0 PTR525,PTR526 None Tyrosine-protein kinase SYK
4YJTA 1.52 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai 4DQ Type1 364 - 633 0 PTR525,PTR526 None Tyrosine-protein kinase SYK
4YJUA 1.67 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai 4DO Type1 364 - 633 0 PTR525,PTR526 None Tyrosine-protein kinase SYK
4YJVA 1.652 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai 4DT Type1 364 - 633 0 PTR525,PTR526 None Tyrosine-protein kinase SYK
4RSSA 1.83 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oooai APEdist_aaao 4MG Type1 364 - 634 0 None None Tyrosine-protein kinase SYK
4XG3A 2.3 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai X3G Type1 363 - 634 0 None None Tyrosine-protein kinase SYK
4XG7A 1.76 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oooai APEdist_aaao X7G Type1 364 - 635 0 None None Tyrosine-protein kinase SYK
4XG8A 2.4 Inactive DFGin‑BLAminus in-out in-none TYR APEdihe_nnnai APEdist_aaan X8G Type1 366 - 635 0 None None Tyrosine-protein kinase SYK
4I0TA 1.7 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_nniai APEdist_aaao 1B6 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
3EMGA 2.6 Inactive DFGin‑BLAminus in-out in-none TYR APEdihe_niiai APEdist_aaai 685 Type1 365 - 631 0 None None Tyrosine-protein kinase SYK
4FL3A 1.9 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 9 - 635 0 None Y348F,Y352F Tyrosine-protein kinase SYK
4FL2A 2.19 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_iioai APEdist_aaao ANP ATPlike 9 - 635 0 None None Tyrosine-protein kinase SYK
3TUCA 2.1 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan FPW Type1.5_Front 358 - 633 0 None None Tyrosine-protein kinase SYK
3TUBA 2.23 Inactive DFGout‑BBAminus in-out none-none TYR APEdihe_nnnai APEdist_aaan FPU Type2 362 - 633 0 None None Tyrosine-protein kinase SYK
3TUDA 2.33 Inactive DFGout‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai FPX Type2 363 - 635 0 None None Tyrosine-protein kinase SYK
4XG2A 2.21 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai No_ligand No_ligand 364 - 635 0 None None Tyrosine-protein kinase SYK
6HM7A 1.64 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai GDH Type1 363 - 633 0 PTR525 None Tyrosine-protein kinase SYK
5LMBB 1.95 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 6ZF Type1 364 - 630 0 PTR525 None Tyrosine-protein kinase SYK
8X5KA 1.8 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 3YT Type1 363 - 632 0 None None Tyrosine-protein kinase SYK
6VOVA 1.95 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai R6D Type1 363 - 629 0 None None Tyrosine-protein kinase SYK
8RRZA 1.75 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai A1H2Y Type1 363 - 633 0 PTR525,PTR526 None Tyrosine-protein kinase SYK
5TR6A 1.93 None DFGin‑BLAminus in-none in-in TYR APEdihe_iiiai APEdist_aaai 7KG Type1 362 - 635 0 None None Tyrosine-protein kinase SYK
4XG3B 2.3 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai X3G Type1 363 - 633 0 None None Tyrosine-protein kinase SYK
4XG4A 2.3 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai X4G Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
4XG6A 2.4 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan X6G Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
4XG8C 2.4 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan X8G Type1 364 - 629 0 None None Tyrosine-protein kinase SYK
4XG9A 2.91 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan X9G Type1 363 - 632 0 None None Tyrosine-protein kinase SYK
4XG9B 2.91 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan X9G Type1 363 - 634 0 None None Tyrosine-protein kinase SYK
5GHVA 2.8 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai X5G Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
5GHVB 2.8 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai X5G Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
8XQ0B 1.95 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai A1LV4 Type1 364 - 634 0 None None Tyrosine-protein kinase SYK
8XQ0D 1.95 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai A1LV4 Type1 364 - 635 0 None None Tyrosine-protein kinase SYK
8XQ1A 1.5 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai A1LV6 Type1 364 - 634 0 None None Tyrosine-protein kinase SYK
8XQ1B 1.5 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai A1LV6 Type1 364 - 634 0 None None Tyrosine-protein kinase SYK
8XQ2A 1.8 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan A1LV7 Type1 363 - 634 0 None None Tyrosine-protein kinase SYK
8XQ2B 1.8 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai A1LV7 Type1 364 - 632 0 None None Tyrosine-protein kinase SYK
1XBBA 1.57 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai STI Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
3FQEA 2.5 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai P5C Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
3FQHB 2.26 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 057 Type1 363 - 633 0 None None Tyrosine-protein kinase SYK
3FQSA 2.1 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 585 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
4FYNA 2.318 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 0VE Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
4FYOA 1.4 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 0VF Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
4FZ6A 1.85 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 0VG Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
4FZ7A 1.75 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 0VH Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
4I0RA 2.1 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 1B4 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
4I0SA 1.98 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 1B5 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
4PUZA 2.085 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai CG9 Type1 363 - 633 0 None None Tyrosine-protein kinase SYK
4PUZB 2.085 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai CG9 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
5T68A 2.93 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 77V Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
5T68B 2.93 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 77V Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
5Y5UB 2.14 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 8OU Type1 363 - 629 0 None None Tyrosine-protein kinase SYK
8WYWA 1.9 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan XFB Type1 364 - 633 0 None None Tyrosine-protein kinase SYK
8WYWB 1.9 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan XFB Type1 365 - 633 0 None None Tyrosine-protein kinase SYK
3VF8A 2.08 None DFGin‑BLAminus in-none in-in TYR APEdihe_iiiai APEdist_aaai 0JE Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
3VF9A 2.3 None DFGin‑BLAminus in-none in-in TYR APEdihe_iiiai APEdist_aaai 477 Type1 364 - 635 0 None None Tyrosine-protein kinase SYK
6SSBA 2.08 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai LUE Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
6ZCQA 2.32 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai QFB Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
6ZCRA 1.73 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 5JG Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
6ZCSA 1.47 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai QFE Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
6ZCUA 1.73 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 5JG Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
6ZCXA 1.66 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai QFQ Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
6ZCYA 1.81 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai QF8 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
8BI2A 1.508 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai QR7 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
5CXZA 1.7 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 55U Type1 363 - 635 0 None K467T Tyrosine-protein kinase SYK
4PX6A 1.6 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 2X6 Type1 364 - 635 0 None K467T Tyrosine-protein kinase SYK

TYR_SYK (Tyrosine-protein kinase SYK)

Total number of chains: 103
Active chains: 36
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 98 95.1% AF-P43405-K1A
DFGin BLBplus 3 2.9% 4FL2A
DFGout BBAminus 1 1.0% 3TUBA
DFGout None 1 1.0% 3TUDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
KSYK_HUMAN 4FL1A 1.79 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN AF-P43405-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 362 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN AF-P43405-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 362 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 1XBAA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4F4PA 2.37 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0SB Type1 365 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4DFNA 2.48 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0K1 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4PV0A 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai CG4 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 6HM6A 2.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai GDK Type1 364 - 632 0 PTR525 None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 3SRVA 1.95 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai S19 Type1 364 - 634 0 PTR525 None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 3SRVB 1.95 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai S19 Type1 364 - 632 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 5LMAA 1.43 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6ZG Type1 363 - 632 0 PTR525 None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 5LMBA 1.95 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6ZF Type1 364 - 634 0 PTR525 None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 6VOVB 1.95 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R6D Type1 364 - 633 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4YJOA 1.6 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 4DF Type1 363 - 632 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4YJPA 1.83 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 4DL Type1 364 - 632 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4YJSA 2.22 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 4DN Type1 364 - 632 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 8RRQA 1.6 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai A1H2W Type1 363 - 632 0 PTR525,PTR526 None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 5TT7A 1.77 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 7KF Type1 358 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 8XQ0A 1.95 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai A1LV4 Type1 364 - 634 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 8XQ0C 1.95 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai A1LV4 Type1 364 - 633 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 1XBCA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 3FQHA 2.26 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 057 Type1 363 - 634 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4GFGA 2.35 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0XF Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 5TIUA 1.49 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 7CU Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 5Y5TA 1.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 8OR Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 5Y5UA 2.14 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 8OU Type1 364 - 634 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4WNMA 2.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3RT Type1 347 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 5C26A 1.95 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 50H Type1 363 - 635 0 PTR525,PTR526 None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 5C27A 2.15 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 50J Type1 363 - 635 0 PTR525,PTR526 None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 6ZC0A 1.97 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai QDZ Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 6ZCPA 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai QFK Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4RX7A 1.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3YV Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4RX8A 1.59 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3YX Type1 364 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 5CXHA 1.9 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 55M Type1 363 - 635 0 None K467T Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4RX9A 1.75 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 3YT Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 5CY3A 1.76 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 55Y Type1 360 - 635 0 None K467T Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4DFLA 1.98 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0K0 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4YJQA 1.34 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai 4DK Type1 364 - 633 0 PTR525,PTR526 None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4YJRA 1.32 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai 4DJ Type1 364 - 633 0 PTR525,PTR526 None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4YJTA 1.52 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai 4DQ Type1 364 - 633 0 PTR525,PTR526 None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4YJUA 1.67 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai 4DO Type1 364 - 633 0 PTR525,PTR526 None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4YJVA 1.652 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai 4DT Type1 364 - 633 0 PTR525,PTR526 None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4RSSA 1.83 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oooai APEdist_aaao 4MG Type1 364 - 634 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4XG3A 2.3 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai X3G Type1 363 - 634 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4XG7A 1.76 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oooai APEdist_aaao X7G Type1 364 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4XG8A 2.4 Inactive DFGin‑BLAminus in-out in-none TYR APEdihe_nnnai APEdist_aaan X8G Type1 366 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4I0TA 1.7 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_nniai APEdist_aaao 1B6 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 3EMGA 2.6 Inactive DFGin‑BLAminus in-out in-none TYR APEdihe_niiai APEdist_aaai 685 Type1 365 - 631 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4FL3A 1.9 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 9 - 635 0 None Y348F,Y352F Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4FL2A 2.19 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_iioai APEdist_aaao ANP ATPlike 9 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 3TUCA 2.1 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan FPW Type1.5_Front 358 - 633 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 3TUBA 2.23 Inactive DFGout‑BBAminus in-out none-none TYR APEdihe_nnnai APEdist_aaan FPU Type2 362 - 633 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 3TUDA 2.33 Inactive DFGout‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai FPX Type2 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4XG2A 2.21 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai No_ligand No_ligand 364 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 6HM7A 1.64 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai GDH Type1 363 - 633 0 PTR525 None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 5LMBB 1.95 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 6ZF Type1 364 - 630 0 PTR525 None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 8X5KA 1.8 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 3YT Type1 363 - 632 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 6VOVA 1.95 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai R6D Type1 363 - 629 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 8RRZA 1.75 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai A1H2Y Type1 363 - 633 0 PTR525,PTR526 None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 5TR6A 1.93 None DFGin‑BLAminus in-none in-in TYR APEdihe_iiiai APEdist_aaai 7KG Type1 362 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4XG3B 2.3 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai X3G Type1 363 - 633 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4XG4A 2.3 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai X4G Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4XG6A 2.4 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan X6G Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4XG8C 2.4 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan X8G Type1 364 - 629 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4XG9A 2.91 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan X9G Type1 363 - 632 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4XG9B 2.91 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan X9G Type1 363 - 634 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 5GHVA 2.8 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai X5G Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 5GHVB 2.8 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai X5G Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 8XQ0B 1.95 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai A1LV4 Type1 364 - 634 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 8XQ0D 1.95 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai A1LV4 Type1 364 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 8XQ1A 1.5 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai A1LV6 Type1 364 - 634 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 8XQ1B 1.5 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai A1LV6 Type1 364 - 634 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 8XQ2A 1.8 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan A1LV7 Type1 363 - 634 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 8XQ2B 1.8 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai A1LV7 Type1 364 - 632 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 1XBBA 1.57 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai STI Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 3FQEA 2.5 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai P5C Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 3FQHB 2.26 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 057 Type1 363 - 633 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 3FQSA 2.1 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 585 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4FYNA 2.318 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 0VE Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4FYOA 1.4 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 0VF Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4FZ6A 1.85 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 0VG Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4FZ7A 1.75 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 0VH Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4I0RA 2.1 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 1B4 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4I0SA 1.98 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 1B5 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4PUZA 2.085 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai CG9 Type1 363 - 633 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4PUZB 2.085 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai CG9 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 5T68A 2.93 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 77V Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 5T68B 2.93 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 77V Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 5Y5UB 2.14 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 8OU Type1 363 - 629 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 8WYWA 1.9 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan XFB Type1 364 - 633 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 8WYWB 1.9 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan XFB Type1 365 - 633 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 3VF8A 2.08 None DFGin‑BLAminus in-none in-in TYR APEdihe_iiiai APEdist_aaai 0JE Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 3VF9A 2.3 None DFGin‑BLAminus in-none in-in TYR APEdihe_iiiai APEdist_aaai 477 Type1 364 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 6SSBA 2.08 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai LUE Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 6ZCQA 2.32 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai QFB Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 6ZCRA 1.73 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 5JG Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 6ZCSA 1.47 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai QFE Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 6ZCUA 1.73 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 5JG Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 6ZCXA 1.66 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai QFQ Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 6ZCYA 1.81 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai QF8 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 8BI2A 1.508 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai QR7 Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 5CXZA 1.7 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 55U Type1 363 - 635 0 None K467T Tyrosine-protein kinase SYK Homo sapiens
KSYK_HUMAN 4PX6A 1.6 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 2X6 Type1 364 - 635 0 None K467T Tyrosine-protein kinase SYK Homo sapiens

TYR_SYK (Tyrosine-protein kinase SYK)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism