TYR_SYK (Tyrosine-protein kinase SYK)

Total number of chains: 103
Active chains: 36
Family: TYR
Uniprot: KSYK_HUMAN
Kinase Domain Residues: 370 - 628
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 98 95.1% AF-P43405-K1A
DFGin BLBplus 3 2.9% 4FL2A
DFGout BBAminus 1 1.0% 3TUBA
DFGout None 1 1.0% 3TUDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
4FL1A 363 635 635.0 ANP:701 ATPlike Active DFGin 6.669 15.063 BLAminus -122.6, -175.53 56.16, 78.38 -92.62, 24.67 287.04, 93.75 -57.67, -38.36 in-in in 8.059 Saltbr-in 2.683 HRD-in -76.27, -50.57 71.77, 3.28 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.55, 85.11 APE9-dihe-in -99.28, 138.37 APE8-dihe-in -79.64, 69.72 APE8-rot-na 29.68 APE67-dihe-in -60.65, -16.95 -44.16, -41.68 APE12-dist-na 13.816 APE11-dist-na 10.806 APE10-dist-na 10.412 APE9-dist-in 7.132 None None None XRAY 1.79 0.197 0.225 A 291 268 5 0 0 0 [[370, 628]] 1.0 4fl1 TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
AF-P43405-K1A 362 635 635.0 No_ligand No_ligand Active DFGin 6.555 14.283 BLAminus -139.44, 178.99 59.92, 76.86 -92.13, 11.74 288.31, 88.77 -62.73, -28.38 in-in in 8.295 Saltbr-in 2.65 HRD-in -79.06, -42.92 61.69, 3.61 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.91, 86.51 APE9-dihe-in -86.43, 140.76 APE8-dihe-in -76.46, 66.17 APE8-rot-na 36.18 APE67-dihe-in -68.53, -16.84 -44.81, -36.23 APE12-dist-na 14.082 APE11-dist-na 9.867 APE10-dist-na 10.621 APE9-dist-in 6.953 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[370, 628]] 1.0 AF-P43405-K1 TYR_SYK_HUMAN TYR 4.4e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
AF-P43405-K3A 362 635 635.0 No_ligand No_ligand Active DFGin 6.251 14.422 BLAminus -144.99, -179.8 59.41, 72.04 -85.9, 11.12 288.49, 84.65 -61.31, -25.31 in-in in 8.477 Saltbr-in 2.702 HRD-in -76.05, -44.23 63.83, -5.43 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.2, 83.8 APE9-dihe-in -94.84, 151.9 APE8-dihe-in -77.3, 64.33 APE8-rot-na 36.0 APE67-dihe-in -67.48, -13.27 -45.03, -34.91 APE12-dist-na 14.354 APE11-dist-na 10.318 APE10-dist-na 11.565 APE9-dist-in 7.192 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[370, 628]] 1.0 AF-P43405-K3 TYR_SYK_HUMAN TYR 4.4e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
1XBAA 363 635 635.0 No_ligand No_ligand Active DFGin 6.283 14.388 BLAminus -126.49, -176.52 55.21, 85.12 -100.47, 21.0 289.26, 85.99 -66.46, -29.63 in-in in 7.924 Saltbr-in 3.28 HRD-in -79.13, -52.49 65.3, 12.61 in-in-in SNCiii in-in ActLoopNT-in 2.769 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.47, 98.05 APE9-dihe-in -115.59, 139.53 APE8-dihe-in -72.13, 70.06 APE8-rot-na 26.48 APE67-dihe-in -72.34, -11.74 -55.87, -33.02 APE12-dist-na 13.371 APE11-dist-na 9.536 APE10-dist-na 9.885 APE9-dist-in 6.476 None None None XRAY 2.0 0.231 0.278 A 291 265 8 0 0 0 [[370, 628]] 1.0 1xba TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4F4PA 365 635 635.0 0SB:60701 Type1 Active DFGin 6.373 14.539 BLAminus -124.15, 178.53 62.38, 80.95 -106.72, 25.8 293.21, 86.39 -66.32, -31.8 in-in in 8.337 Saltbr-in 3.547 HRD-in -76.55, -51.58 69.18, 8.78 in-in-in SNCiii in-in ActLoopNT-in 2.995 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.78, 99.03 APE9-dihe-in -104.94, 133.88 APE8-dihe-in -73.17, 77.69 APE8-rot-na 29.01 APE67-dihe-in -66.28, -12.67 -56.63, -36.73 APE12-dist-na 13.315 APE11-dist-na 9.564 APE10-dist-na 10.422 APE9-dist-in 6.871 None None None XRAY 2.37 0.241 0.285 A 273 260 11 0 0 0 [[370, 628]] 1.0 4f4p TYR_SYK_HUMAN TYR 4.3e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4DFNA 363 635 635.0 0K1:60701 Type1 Active DFGin 6.49 14.454 BLAminus -130.15, -170.0 61.62, 83.88 -107.34, 23.58 294.6, 91.76 -72.41, -22.45 in-in in 8.746 Saltbr-in 3.183 HRD-in -85.27, -46.79 70.7, 5.96 in-in-in SNCiii in-in ActLoopNT-in 3.006 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.4, 98.4 APE9-dihe-in -102.46, 134.32 APE8-dihe-in -74.07, 82.6 APE8-rot-na 30.43 APE67-dihe-in -65.57, -16.86 -58.25, -34.59 APE12-dist-na 13.655 APE11-dist-na 10.708 APE10-dist-na 11.325 APE9-dist-in 7.301 None None None XRAY 2.48 0.222 0.273 A 274 268 5 0 0 0 [[370, 628]] 1.0 4dfn TYR_SYK_HUMAN TYR 4.4e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4PV0A 363 635 635.0 CG4:60701 Type1 Active DFGin 6.401 14.607 BLAminus -130.2, -175.25 67.21, 78.78 -101.45, 20.11 290.66, 99.39 -65.44, -27.35 in-in in 8.466 Saltbr-in 3.44 HRD-in -78.38, -54.31 73.62, 9.17 in-in-in SNCiii in-in ActLoopNT-in 2.835 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.94, 106.38 APE9-dihe-in -116.79, 139.9 APE8-dihe-in -79.38, 71.94 APE8-rot-na 33.78 APE67-dihe-in -68.26, -13.59 -53.62, -38.3 APE12-dist-na 13.161 APE11-dist-na 9.867 APE10-dist-na 10.488 APE9-dist-in 6.938 None None None XRAY 2.0 0.231 0.282 A 275 266 7 0 0 0 [[370, 628]] 1.0 4pv0 TYR_SYK_HUMAN TYR 4.5e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
6HM6A 364 632 635.0 GDK:701 Type1 Active DFGin 6.51 14.716 BLAminus -135.72, 178.12 60.9, 85.59 -101.68, 17.9 294.15, 88.35 -56.95, -33.53 in-in in 8.255 Saltbr-in 2.986 HRD-in -76.78, -53.52 71.64, 11.57 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -60.26, 138.11 APE9-dihe-in -138.15, 72.71 APE8-dihe-in -77.49, 77.46 APE8-rot-na 32.95 APE67-dihe-in -66.81, -17.94 -54.41, -33.99 APE12-dist-na 999.0 APE11-dist-na 9.239 APE10-dist-na 7.753 APE9-dist-in 7.668 None PTR525 PTR525 XRAY 2.1 0.217 0.29 A 276 261 8 0 0 2 [[370, 628]] 1.0 6hm6 TYR_SYK_HUMAN TYR 4.5e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
3SRVA 364 634 635.0 S19:1 Type1 Active DFGin 6.278 14.024 BLAminus -137.61, -172.24 65.42, 72.28 -96.27, 25.84 296.23, 89.02 -63.12, -26.69 in-in in 7.748 Saltbr-in 2.717 HRD-in -84.44, -49.93 72.25, 5.56 in-in-in SNCiii in-in ActLoopNT-in 2.973 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.48, 113.26 APE9-dihe-in -101.68, 153.86 APE8-dihe-in -78.64, 68.9 APE8-rot-na 34.87 APE67-dihe-in -67.25, -14.96 -56.26, -32.84 APE12-dist-na 12.931 APE11-dist-na 10.491 APE10-dist-na 11.935 APE9-dist-in 7.216 None PTR525 PTR525 XRAY 1.95 0.188 0.241 A 277 263 8 0 0 0 [[370, 628]] 1.0 3srv TYR_SYK_HUMAN TYR 4.6e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
3SRVB 364 632 635.0 S19:2 Type1 Active DFGin 6.283 14.236 BLAminus -130.89, -171.96 62.47, 72.82 -96.45, 25.83 293.72, 91.52 -65.61, -26.16 in-in in 7.663 Saltbr-in 2.967 HRD-in -72.4, -57.08 74.0, 8.38 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -91.35, 90.32 APE9-dihe-in -97.42, 146.07 APE8-dihe-in -79.19, 69.07 APE8-rot-na 34.2 APE67-dihe-in -70.71, -15.69 -52.0, -32.14 APE12-dist-na 13.211 APE11-dist-na 10.261 APE10-dist-na 10.871 APE9-dist-in 6.984 None None None XRAY 1.95 0.188 0.241 B 277 263 6 0 0 0 [[370, 628]] 1.0 3srv TYR_SYK_HUMAN TYR 4.6e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
5LMAA 363 632 635.0 6ZG:701 Type1 Active DFGin 6.708 14.754 BLAminus -128.5, -174.48 63.43, 65.54 -91.18, 18.15 286.4, 81.6 -62.6, -20.77 in-in in 8.001 Saltbr-in 2.769 HRD-in -78.56, -50.71 72.45, 5.63 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -59.08, 136.12 APE9-dihe-in -133.37, 70.56 APE8-dihe-in -71.66, 73.32 APE8-rot-na 31.65 APE67-dihe-in -63.61, -19.89 -49.48, -39.64 APE12-dist-na 999.0 APE11-dist-na 9.212 APE10-dist-na 7.699 APE9-dist-in 7.622 None PTR525 PTR525 XRAY 1.43 0.157 0.183 A 277 268 2 0 0 2 [[370, 628]] 1.0 5lma TYR_SYK_HUMAN TYR 4.6e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
5LMBA 364 634 635.0 6ZF:701 Type1 Active DFGin 6.448 14.283 BLAminus -131.02, -173.87 62.28, 69.39 -93.16, 19.0 290.08, 82.25 -59.68, -28.46 in-in in 7.696 Saltbr-in 2.454 HRD-in -78.06, -53.9 76.38, 4.89 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.66, 104.96 APE9-dihe-in -108.73, 152.4 APE8-dihe-in -79.7, 70.25 APE8-rot-na 31.84 APE67-dihe-in -69.34, -16.13 -51.43, -34.69 APE12-dist-na 13.073 APE11-dist-na 10.546 APE10-dist-na 11.448 APE9-dist-in 6.959 None PTR525 PTR525 XRAY 1.95 0.178 0.228 A 277 265 6 0 0 0 [[370, 628]] 1.0 5lmb TYR_SYK_HUMAN TYR 4.6e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
6VOVB 364 633 635.0 R6D:701 Type1 Active DFGin 6.674 14.628 BLAminus -133.89, -172.81 60.07, 70.15 -88.26, 20.03 288.32, 89.62 -58.86, -27.32 in-in in 8.08 Saltbr-in 2.622 HRD-in -78.67, -51.68 71.89, 6.23 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.76, 97.82 APE9-dihe-in -115.45, 146.07 APE8-dihe-in -78.23, 69.53 APE8-rot-na 28.65 APE67-dihe-in -63.96, -14.94 -44.81, -41.99 APE12-dist-na 13.646 APE11-dist-na 10.448 APE10-dist-na 11.033 APE9-dist-in 6.814 None None None XRAY 1.95 0.22 0.268 B 281 264 6 0 0 0 [[370, 628]] 1.0 6vov TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4YJOA 363 632 635.0 4DF:701 Type1 Active DFGin 7.151 15.404 BLAminus -136.57, 178.57 59.58, 80.7 -95.16, 22.65 286.36, 75.19 -55.96, -31.16 in-in in 8.32 Saltbr-in 3.044 HRD-in -80.48, -52.4 72.29, 6.84 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.5, 127.44 APE9-dihe-in -144.08, 83.31 APE8-dihe-in -75.74, 70.97 APE8-rot-na 33.07 APE67-dihe-in -63.43, -16.56 -52.99, -37.5 APE12-dist-na 999.0 APE11-dist-na 10.63 APE10-dist-na 7.9 APE9-dist-in 7.507 None None None XRAY 1.6 0.186 0.23 A 281 267 3 0 0 3 [[370, 628]] 1.0 4yjo TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4YJPA 364 632 635.0 4DL:701 Type1 Active DFGin 6.981 15.824 BLAminus -136.12, -172.87 58.52, 69.5 -93.88, 23.3 283.25, 78.78 -63.0, -28.48 in-in in 8.499 Saltbr-in 2.787 HRD-in -81.51, -48.52 67.75, 7.04 in-in-in SNCiii in-in ActLoopNT-in 2.945 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -52.7, 125.7 APE9-dihe-in -135.05, 78.45 APE8-dihe-in -76.25, 75.65 APE8-rot-na 35.36 APE67-dihe-in -66.34, -13.74 -58.49, -30.71 APE12-dist-na 999.0 APE11-dist-na 9.452 APE10-dist-na 7.369 APE9-dist-in 7.257 None None None XRAY 1.83 0.196 0.258 A 281 263 6 0 0 3 [[370, 628]] 1.0 4yjp TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4YJSA 364 632 635.0 4DN:701 Type1 Active DFGin 6.811 15.74 BLAminus -130.65, -173.59 54.32, 75.2 -95.58, 22.43 287.83, 71.53 -54.84, -38.21 in-in in 8.514 Saltbr-in 3.084 HRD-in -80.45, -49.01 70.65, 8.19 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -50.21, 136.65 APE9-dihe-in -143.79, 77.69 APE8-dihe-in -76.44, 79.91 APE8-rot-na 34.0 APE67-dihe-in -64.44, -15.73 -58.23, -33.75 APE12-dist-na 13.07 APE11-dist-na 9.224 APE10-dist-na 7.474 APE9-dist-in 7.068 None None None XRAY 2.22 0.172 0.226 A 281 257 12 0 0 0 [[370, 628]] 1.0 4yjs TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
8RRQA 363 632 635.0 A1H2W:701 Type1 Active DFGin 6.215 14.411 BLAminus -133.38, -167.55 71.76, 65.57 -94.48, 19.17 287.36, 93.75 -65.47, -22.18 in-in in 8.082 Saltbr-in 2.803 HRD-in -81.18, -51.78 70.8, 9.1 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.09, 108.93 APE9-dihe-in -135.72, 149.25 APE8-dihe-in -81.85, 69.97 APE8-rot-na 37.74 APE67-dihe-in -65.72, -15.06 -52.32, -34.71 APE12-dist-na 999.0 APE11-dist-na 10.224 APE10-dist-na 10.574 APE9-dist-in 6.743 None PTR525,PTR526 PTR525,PTR526 XRAY 1.6 0.178 0.211 A 282 268 2 0 0 2 [[370, 628]] 1.0 8rrq TYR_SYK_HUMAN TYR 4.9e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
5TT7A 358 635 635.0 7KF:60901 Type1 Active DFGin 6.311 14.341 BLAminus -130.62, -177.29 62.11, 72.82 -94.96, 21.67 289.95, 80.8 -60.6, -26.94 in-in in 7.709 Saltbr-in 2.84 HRD-in -77.7, -52.28 69.96, 13.2 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.65, 88.09 APE9-dihe-in -107.14, 140.48 APE8-dihe-in -78.3, 78.38 APE8-rot-na 32.04 APE67-dihe-in -64.56, -15.37 -56.64, -35.35 APE12-dist-na 13.888 APE11-dist-na 10.557 APE10-dist-na 10.342 APE9-dist-in 6.849 None None None XRAY 1.77 0.208 0.234 A 289 270 8 0 0 0 [[370, 628]] 1.0 5tt7 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
8XQ0A 364 634 635.0 A1LV4:701 Type1 Active DFGin 6.154 14.743 BLAminus -131.25, -165.27 59.08, 66.28 -91.94, 24.84 295.79, 89.46 -66.54, -26.0 in-in in 8.841 Saltbr-in 2.39 HRD-in -77.49, -50.4 67.59, 11.98 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.4, 148.65 APE9-dihe-in -142.22, 83.4 APE8-dihe-in -79.88, 80.85 APE8-rot-na 30.05 APE67-dihe-in -71.39, -10.32 -63.91, -29.36 APE12-dist-na 999.0 APE11-dist-na 8.661 APE10-dist-na 7.465 APE9-dist-in 7.084 None None None XRAY 1.95 0.222 0.265 A 290 264 7 0 0 4 [[370, 628]] 1.0 8xq0 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
8XQ0C 364 633 635.0 A1LV4:701 Type1 Active DFGin 6.064 14.771 BLAminus -131.08, -166.05 60.61, 65.77 -92.17, 22.95 297.06, 91.43 -65.35, -22.59 in-in in 8.197 Saltbr-in 2.474 HRD-in -81.66, -50.49 70.19, 9.23 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.0, 152.43 APE9-dihe-in -139.04, 83.13 APE8-dihe-in -80.21, 76.04 APE8-rot-na 29.28 APE67-dihe-in -67.25, -12.04 -57.38, -34.01 APE12-dist-na 999.0 APE11-dist-na 8.547 APE10-dist-na 7.75 APE9-dist-in 7.186 None None None XRAY 1.95 0.222 0.265 C 290 263 7 0 0 3 [[370, 628]] 1.0 8xq0 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
1XBCA 363 635 635.0 STU:60001 Type1 Active DFGin 6.699 14.236 BLAminus -133.2, -171.25 54.9, 81.04 -97.63, 25.87 287.7, 80.31 -62.67, -30.77 in-in in 8.107 Saltbr-in 2.681 HRD-in -73.91, -54.08 72.64, 5.62 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.93, 102.31 APE9-dihe-in -115.14, 122.86 APE8-dihe-in -77.21, 74.28 APE8-rot-na 27.13 APE67-dihe-in -62.04, -14.77 -51.56, -42.64 APE12-dist-na 10.226 APE11-dist-na 10.661 APE10-dist-na 9.591 APE9-dist-in 6.83 None None None XRAY 2.0 0.246 0.294 A 291 267 6 0 0 0 [[370, 628]] 1.0 1xbc TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
3FQHA 363 634 635.0 057:1 Type1 Active DFGin 6.389 14.293 BLAminus -136.21, -174.07 56.01, 83.39 -99.37, 22.02 289.52, 83.78 -53.8, -32.62 in-in in 7.989 Saltbr-in 2.983 HRD-in -76.47, -53.05 70.67, 6.23 in-in-in SNCiii in-in ActLoopNT-in 2.771 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.93, 113.08 APE9-dihe-in -110.56, 145.62 APE8-dihe-in -76.43, 69.28 APE8-rot-na 29.47 APE67-dihe-in -67.72, -12.14 -50.67, -39.65 APE12-dist-na 12.19 APE11-dist-na 10.46 APE10-dist-na 11.27 APE9-dist-in 6.993 None None None XRAY 2.26 0.216 0.259 A 291 262 10 0 0 0 [[370, 628]] 1.0 3fqh TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4GFGA 363 635 635.0 0XF:60701 Type1 Active DFGin 6.382 14.706 BLAminus -133.41, -165.6 61.44, 68.78 -94.44, 29.51 290.84, 74.86 -64.09, -30.1 in-in in 8.551 Saltbr-in 3.497 HRD-in -86.12, -47.8 68.36, 5.25 in-in-in SNCiii in-in ActLoopNT-in 2.866 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -53.12, 138.6 APE9-dihe-in -110.15, 137.21 APE8-dihe-in -65.63, 68.92 APE8-rot-na 25.72 APE67-dihe-in -68.08, -17.47 -52.98, -35.53 APE12-dist-na 9.582 APE11-dist-na 10.629 APE10-dist-na 11.706 APE9-dist-in 7.231 None None None XRAY 2.35 0.221 0.246 A 291 273 0 0 0 0 [[370, 628]] 1.0 4gfg TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
5TIUA 363 635 635.0 7CU:60701 Type1 Active DFGin 6.578 14.366 BLAminus -131.38, -173.31 61.91, 73.7 -95.93, 19.79 288.63, 86.78 -61.17, -26.75 in-in in 7.801 Saltbr-in 2.735 HRD-in -74.96, -48.82 70.27, 6.32 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.61, 84.89 APE9-dihe-in -101.52, 144.24 APE8-dihe-in -80.61, 68.84 APE8-rot-na 28.9 APE67-dihe-in -65.13, -16.04 -45.65, -40.25 APE12-dist-na 13.962 APE11-dist-na 10.844 APE10-dist-na 10.689 APE9-dist-in 7.1 None None None XRAY 1.49 0.186 0.203 A 291 262 11 0 0 0 [[370, 628]] 1.0 5tiu TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
5Y5TA 363 635 635.0 8OR:701 Type1 Active DFGin 6.63 14.716 BLAminus -124.89, -179.45 65.71, 71.78 -93.94, 17.9 289.28, 88.8 -59.66, -30.83 in-in in 8.045 Saltbr-in 2.706 HRD-in -76.54, -52.99 73.97, 1.93 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -91.38, 59.43 APE9-dihe-in -101.74, 134.18 APE8-dihe-in -79.02, 75.85 APE8-rot-na 32.57 APE67-dihe-in -64.44, -15.76 -52.79, -38.69 APE12-dist-na 8.812 APE11-dist-na 11.931 APE10-dist-na 9.712 APE9-dist-in 6.991 None None None XRAY 1.8 0.196 0.234 A 293 263 10 0 0 0 [[370, 628]] 1.0 5y5t TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
5Y5UA 364 634 635.0 8OU:701 Type1 Active DFGin 6.434 14.099 BLAminus -136.65, 173.94 66.9, 89.62 -105.43, 28.84 296.27, 90.39 -60.97, -30.93 in-in in 7.994 Saltbr-in 2.585 HRD-in -70.93, -52.74 73.81, 2.31 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.85, 121.36 APE9-dihe-in -125.49, 151.88 APE8-dihe-in -80.17, 69.97 APE8-rot-na 36.19 APE67-dihe-in -65.59, -17.51 -56.34, -35.15 APE12-dist-na 13.325 APE11-dist-na 10.867 APE10-dist-na 11.802 APE9-dist-in 7.226 None None None XRAY 2.14 0.239 0.26 A 293 266 5 0 0 0 [[370, 628]] 1.0 5y5u TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4WNMA 347 635 635.0 3RT:60701 Type1 Active DFGin 6.269 14.204 BLAminus -122.7, 177.9 75.28, 74.2 -103.7, 21.48 302.37, 85.65 -56.81, -27.59 in-in in 8.279 Saltbr-in 2.749 HRD-in -73.5, -57.83 70.01, 16.8 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -49.99, 114.81 APE9-dihe-in -116.39, 136.86 APE8-dihe-in -71.67, 69.27 APE8-rot-na 29.91 APE67-dihe-in -63.86, -22.22 -60.87, -29.91 APE12-dist-na 12.409 APE11-dist-na 9.717 APE10-dist-na 10.738 APE9-dist-in 7.121 None None None XRAY 2.5 0.207 0.26 A 299 272 4 0 0 0 [[370, 628]] 1.0 4wnm TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
5C26A 363 635 635.0 50H:60701 Type1 Active DFGin 6.407 14.905 BLAminus -133.47, -175.05 59.93, 80.73 -95.24, 23.48 291.98, 89.4 -57.38, -35.1 in-in in 8.232 Saltbr-in 2.756 HRD-in -77.18, -53.12 70.55, 7.56 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.23, 98.53 APE9-dihe-in -110.63, 147.85 APE8-dihe-in -78.58, 69.25 APE8-rot-na 30.18 APE67-dihe-in -65.45, -18.57 -48.55, -37.73 APE12-dist-na 13.311 APE11-dist-na 10.573 APE10-dist-na 10.592 APE9-dist-in 6.84 None PTR525,PTR526 PTR525,PTR526 XRAY 1.95 0.186 0.215 A 299 273 0 0 0 0 [[370, 628]] 1.0 5c26 TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
5C27A 363 635 635.0 50J:60701 Type1 Active DFGin 6.359 14.612 BLAminus -130.06, -175.69 60.48, 84.21 -100.61, 25.88 296.18, 90.13 -67.7, -23.97 in-in in 8.325 Saltbr-in 2.79 HRD-in -75.03, -53.41 71.91, 4.7 in-in-in SNCiii in-in ActLoopNT-in 3.001 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.32, 89.13 APE9-dihe-in -103.36, 145.0 APE8-dihe-in -82.82, 67.41 APE8-rot-na 29.25 APE67-dihe-in -67.99, -14.11 -44.6, -40.88 APE12-dist-na 13.373 APE11-dist-na 10.038 APE10-dist-na 10.082 APE9-dist-in 6.751 None PTR525,PTR526 PTR525,PTR526 XRAY 2.15 0.179 0.225 A 299 273 0 0 0 0 [[370, 628]] 1.0 5c27 TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
6ZC0A 363 635 635.0 QDZ:60701 Type1 Active DFGin 6.439 14.256 BLAminus -134.4, -168.89 64.15, 77.73 -98.13, 17.43 287.82, 84.9 -56.42, -33.19 in-in in 7.805 Saltbr-in 3.302 HRD-in -74.71, -54.58 68.95, 18.65 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.33, 89.82 APE9-dihe-in -113.19, 137.33 APE8-dihe-in -88.05, 72.58 APE8-rot-na 31.66 APE67-dihe-in -60.74, -19.2 -42.14, -42.2 APE12-dist-na 13.59 APE11-dist-na 10.088 APE10-dist-na 9.285 APE9-dist-in 6.833 None None None XRAY 1.97 0.194 0.229 A 299 264 9 0 0 0 [[370, 628]] 1.0 6zc0 TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
6ZCPA 363 635 635.0 QFK:60701 Type1 Active DFGin 6.434 14.114 BLAminus -125.39, -166.55 56.04, 77.4 -99.95, 22.28 287.9, 88.75 -70.24, -19.9 in-in in 8.09 Saltbr-in 3.23 HRD-in -73.61, -47.62 64.51, 7.94 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.33, 97.29 APE9-dihe-in -119.56, 130.58 APE8-dihe-in -81.48, 76.65 APE8-rot-na 28.01 APE67-dihe-in -69.79, -11.02 -50.04, -33.72 APE12-dist-na 13.983 APE11-dist-na 11.018 APE10-dist-na 10.323 APE9-dist-in 7.258 None None None XRAY 2.2 0.213 0.234 A 299 264 9 0 0 0 [[370, 628]] 1.0 6zcp TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4RX7A 363 635 635.0 3YV:60703 Type1 Active DFGin 6.368 14.51 BLAminus -135.93, -162.06 57.15, 54.11 -83.47, 19.55 290.31, 87.83 -58.61, -26.4 in-in in 8.151 Saltbr-in 2.906 HRD-in -74.07, -52.97 72.74, 4.77 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.3, 124.77 APE9-dihe-in -107.76, 142.43 APE8-dihe-in -82.91, 72.86 APE8-rot-na 31.05 APE67-dihe-in -64.64, -19.89 -48.22, -37.19 APE12-dist-na 12.646 APE11-dist-na 10.977 APE10-dist-na 11.221 APE9-dist-in 7.134 None None None XRAY 1.8 0.182 0.203 A 289 270 3 0 0 0 [[370, 628]] 1.0 4rx7 TYR_SYK_HUMAN TYR 3.9e-90 307.6 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4RX8A 364 635 635.0 3YX:60703 Type1 Active DFGin 6.375 14.344 BLAminus -127.63, -170.0 62.54, 75.55 -100.59, 22.48 287.33, 90.81 -63.45, -25.44 in-in in 8.034 Saltbr-in 2.841 HRD-in -76.4, -50.39 68.53, 9.44 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.6, 95.02 APE9-dihe-in -111.13, 149.03 APE8-dihe-in -81.54, 69.96 APE8-rot-na 29.76 APE67-dihe-in -66.91, -14.89 -51.35, -37.09 APE12-dist-na 999.0 APE11-dist-na 10.715 APE10-dist-na 10.621 APE9-dist-in 6.982 None None None XRAY 1.59 0.175 0.207 A 289 266 6 0 0 1 [[370, 628]] 1.0 4rx8 TYR_SYK_HUMAN TYR 3.9e-90 307.6 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
5CXHA 363 635 635.0 55M:60701 Type1 Active DFGin 6.44 14.323 BLAminus -133.42, -179.45 56.74, 83.68 -97.45, 24.47 292.79, 86.46 -58.74, -36.41 in-in in 7.662 Saltbr-in 2.858 HRD-in -70.81, -53.82 70.99, 7.51 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.96, 96.35 APE9-dihe-in -104.24, 139.79 APE8-dihe-in -78.53, 71.61 APE8-rot-na 29.83 APE67-dihe-in -66.63, -19.71 -51.23, -33.62 APE12-dist-na 13.123 APE11-dist-na 10.837 APE10-dist-na 10.88 APE9-dist-in 7.052 K467T None None XRAY 1.9 0.176 0.205 A 289 273 0 0 0 0 [[370, 628]] 1.0 5cxh TYR_SYK_HUMAN TYR 3.9e-90 307.6 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4RX9A 363 635 635.0 3YT:60702 Type1 Active DFGin 6.536 14.498 BLAminus -131.55, -166.02 53.8, 76.49 -95.21, 18.16 288.88, 90.96 -57.69, -29.73 in-in in 8.168 Saltbr-in 3.125 HRD-in -77.32, -52.67 70.66, 10.77 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.14, 87.16 APE9-dihe-in -107.75, 147.74 APE8-dihe-in -79.62, 70.69 APE8-rot-na 28.2 APE67-dihe-in -66.03, -15.15 -48.72, -38.82 APE12-dist-na 999.0 APE11-dist-na 11.076 APE10-dist-na 10.761 APE9-dist-in 6.997 None None None XRAY 1.75 0.175 0.197 A 290 264 9 0 0 1 [[370, 628]] 1.0 4rx9 TYR_SYK_HUMAN TYR 4e-90 307.6 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
5CY3A 360 635 635.0 55Y:60701 Type1 Active DFGin 6.295 14.611 BLAminus -132.49, 178.84 54.8, 80.29 -90.47, 18.93 290.07, 88.96 -55.0, -39.22 in-in in 8.197 Saltbr-in 2.763 HRD-in -80.6, -49.34 69.47, 8.41 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.58, 101.42 APE9-dihe-in -106.21, 146.28 APE8-dihe-in -84.7, 72.08 APE8-rot-na 31.82 APE67-dihe-in -66.44, -12.67 -53.8, -35.38 APE12-dist-na 13.383 APE11-dist-na 10.361 APE10-dist-na 10.987 APE9-dist-in 7.136 K467T None None XRAY 1.76 0.171 0.195 A 291 274 2 0 0 0 [[370, 628]] 1.0 5cy3 TYR_SYK_HUMAN TYR 4e-90 307.6 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4DFLA 363 635 635.0 0K0:60701 Type1 Inactive DFGin 6.483 14.571 BLAminus -118.07, -176.51 65.46, 77.03 -97.43, 24.23 290.23, 82.73 -67.62, -27.84 in-in in 8.444 Saltbr-in 3.134 HRD-in -79.8, -55.87 75.57, 9.89 in-in-out SNCiio in-out ActLoopNT-in 2.948 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 50.15, 72.02 APE9-dihe-in -112.79, 133.67 APE8-dihe-in -76.3, 73.19 APE8-rot-na 32.11 APE67-dihe-in -65.46, -14.43 -51.92, -39.05 APE12-dist-na 13.047 APE11-dist-na 10.349 APE10-dist-na 9.761 APE9-dist-in 6.799 None None None XRAY 1.98 0.199 0.243 A 274 262 11 0 0 0 [[370, 628]] 1.0 4dfl TYR_SYK_HUMAN TYR 4.4e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4YJQA 364 633 635.0 4DK:701 Type1 Inactive DFGin 6.736 15.804 BLAminus -134.82, -177.19 61.29, 79.22 -100.06, 24.96 286.87, 77.55 -63.45, -29.36 in-out in 8.758 Saltbr-out 4.895 HRD-in -81.67, -53.67 71.29, 13.22 out-in-in SNCoii in-in ActLoopNT-in 2.91 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.36, 108.33 APE9-dihe-in -126.44, 157.88 APE8-dihe-in -80.8, 70.11 APE8-rot-na 32.3 APE67-dihe-in -67.03, -13.75 -58.2, -31.61 APE12-dist-na 13.861 APE11-dist-na 10.931 APE10-dist-na 11.308 APE9-dist-in 6.894 None PTR525,PTR526 PTR525,PTR526 XRAY 1.34 0.162 0.183 A 281 266 4 0 0 0 [[370, 628]] 1.0 4yjq TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4YJRA 364 633 635.0 4DJ:701 Type1 Inactive DFGin 6.624 15.887 BLAminus -132.72, -177.45 60.79, 79.89 -101.88, 24.11 286.03, 77.25 -63.73, -27.17 in-out in 8.78 Saltbr-out 4.806 HRD-in -81.52, -53.74 71.69, 12.94 out-in-in SNCoii in-in ActLoopNT-in 2.928 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.41, 106.79 APE9-dihe-in -125.28, 158.73 APE8-dihe-in -81.3, 69.56 APE8-rot-na 32.68 APE67-dihe-in -66.27, -14.56 -57.04, -32.84 APE12-dist-na 13.842 APE11-dist-na 10.887 APE10-dist-na 11.238 APE9-dist-in 6.86 None PTR525,PTR526 PTR525,PTR526 XRAY 1.32 0.157 0.18 A 281 265 5 0 0 0 [[370, 628]] 1.0 4yjr TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4YJTA 364 633 635.0 4DQ:702 Type1 Inactive DFGin 7.064 15.582 BLAminus -131.45, -174.52 58.96, 73.99 -96.84, 26.0 284.85, 76.07 -63.21, -26.17 in-out in 8.667 Saltbr-out 3.811 HRD-in -83.12, -51.93 70.87, 9.98 out-in-in SNCoii in-in ActLoopNT-in 2.893 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.18, 103.7 APE9-dihe-in -124.22, 158.86 APE8-dihe-in -80.04, 67.83 APE8-rot-na 30.81 APE67-dihe-in -66.36, -14.14 -52.34, -34.06 APE12-dist-na 14.101 APE11-dist-na 10.888 APE10-dist-na 11.114 APE9-dist-in 6.862 None PTR525,PTR526 PTR525,PTR526 XRAY 1.52 0.176 0.208 A 281 270 0 0 0 0 [[370, 628]] 1.0 4yjt TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4YJUA 364 633 635.0 4DO:701 Type1 Inactive DFGin 7.107 15.38 BLAminus -134.61, -176.9 55.67, 76.17 -94.03, 20.15 284.44, 74.82 -57.56, -25.54 in-out in 8.574 Saltbr-out 3.757 HRD-in -78.76, -50.17 71.23, 5.94 out-in-in SNCoii in-in ActLoopNT-in 2.861 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.06, 116.81 APE9-dihe-in -121.69, 162.72 APE8-dihe-in -76.87, 70.03 APE8-rot-na 31.7 APE67-dihe-in -64.01, -12.06 -45.6, -41.35 APE12-dist-na 999.0 APE11-dist-na 11.421 APE10-dist-na 11.903 APE9-dist-in 6.828 None PTR525,PTR526 PTR525,PTR526 XRAY 1.67 0.168 0.201 A 281 267 3 0 0 3 [[370, 628]] 1.0 4yju TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4YJVA 364 633 635.0 4DT:701 Type1 Inactive DFGin 7.058 15.539 BLAminus -132.12, -177.62 58.9, 78.21 -97.23, 24.66 284.8, 77.05 -61.21, -27.61 in-out in 8.601 Saltbr-out 4.961 HRD-in -80.51, -52.41 71.92, 9.69 out-in-in SNCoii in-in ActLoopNT-in 2.903 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.0, 101.75 APE9-dihe-in -120.35, 161.01 APE8-dihe-in -81.1, 68.03 APE8-rot-na 32.46 APE67-dihe-in -66.69, -14.4 -54.32, -33.4 APE12-dist-na 13.919 APE11-dist-na 10.8 APE10-dist-na 11.156 APE9-dist-in 6.838 None PTR525,PTR526 PTR525,PTR526 XRAY 1.652 0.177 0.222 A 281 265 5 0 0 0 [[370, 628]] 1.0 4yjv TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4RSSA 364 634 635.0 4MG:701 Type1 Inactive DFGin 6.362 14.374 BLAminus -125.51, 178.89 70.7, 70.71 -93.1, 15.53 292.82, 95.43 -58.12, -23.53 in-in in 7.98 Saltbr-in 2.647 HRD-in -80.43, -50.69 72.79, 4.21 in-in-out SNCiio in-out ActLoopNT-in 2.983 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -83.33, -31.98 APE9-dihe-out -62.19, -39.48 APE8-dihe-out -88.75, -5.81 APE8-rot-na 36.86 APE67-dihe-in -61.38, -18.45 -51.57, -40.88 APE12-dist-na 11.195 APE11-dist-na 13.649 APE10-dist-na 16.633 APE9-dist-out 10.407 None None None XRAY 1.83 0.214 0.249 A 290 269 2 0 0 0 [[370, 628]] 1.0 4rss TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4XG3A 363 634 635.0 X3G:701 Type1 Inactive DFGin 6.561 14.269 BLAminus -123.77, -176.77 60.27, 75.02 -93.24, 14.93 290.25, 93.45 -52.4, -30.37 in-out in 7.883 Saltbr-out 4.373 HRD-in -78.91, -49.84 68.75, 12.99 out-in-in SNCoii in-in ActLoopNT-in 2.812 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.51, 96.9 APE9-dihe-in -112.53, 139.55 APE8-dihe-in -74.31, 78.49 APE8-rot-na 32.23 APE67-dihe-in -68.63, -15.73 -57.45, -34.9 APE12-dist-na 14.073 APE11-dist-na 11.005 APE10-dist-na 10.913 APE9-dist-in 7.156 None None None XRAY 2.3 0.199 0.226 A 290 262 10 0 0 0 [[370, 628]] 1.0 4xg3 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4XG7A 364 635 635.0 X7G:60701 Type1 Inactive DFGin 6.447 14.323 BLAminus -121.7, -179.92 65.73, 76.06 -96.8, 16.58 293.04, 92.3 -59.19, -26.5 in-in in 7.786 Saltbr-in 2.689 HRD-in -75.48, -50.53 70.33, 10.44 in-in-out SNCiio in-out ActLoopNT-in 2.919 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -77.68, -30.64 APE9-dihe-out -62.97, -34.6 APE8-dihe-out -91.68, -6.53 APE8-rot-na 34.14 APE67-dihe-in -64.14, -15.96 -52.05, -39.51 APE12-dist-na 11.128 APE11-dist-na 13.477 APE10-dist-na 16.568 APE9-dist-out 10.333 None None None XRAY 1.76 0.226 0.242 A 290 265 7 0 0 0 [[370, 628]] 1.0 4xg7 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4XG8A 366 635 635.0 X8G:700 Type1 Inactive DFGin 6.391 14.632 BLAminus -120.1, -177.66 66.71, 68.41 -88.21, 14.67 295.9, 86.73 -47.78, -34.81 in-out in 8.259 Saltbr-out 5.005 HRD-in -67.74, -56.67 79.0, 1.4 out-in-none SNCoin in-none ActLoopNT-in 2.808 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 10.07 APE8-rot-na 35.22 APE67-dihe-in -73.7, -4.5 -52.82, -36.93 APE12-dist-na 11.636 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.249 0.275 A 290 258 12 0 0 3 [[370, 628]] 1.0 4xg8 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4I0TA 363 635 635.0 1B6:60701 Type1 Inactive DFGin 6.448 14.275 BLAminus -133.28, -166.54 54.17, 83.04 -99.17, 23.72 289.92, 92.88 -54.78, -30.8 in-in in 8.482 Saltbr-in 2.757 HRD-in -78.62, -52.01 75.91, 3.75 in-in-out SNCiio in-out ActLoopNT-in 3.005 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.47 APE8-dihe-in -63.58, 54.66 APE8-rot-na 27.19 APE67-dihe-in -65.32, -17.31 -39.09, -36.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.562 None None None XRAY 1.7 0.236 0.268 A 291 262 11 0 0 5 [[370, 628]] 1.0 4i0t TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
3EMGA 365 631 635.0 685:685 Type1 Inactive DFGin 6.424 14.435 BLAminus -130.99, -164.55 52.75, 65.2 -80.56, 24.97 299.65, 78.19 -64.0, -22.78 in-out in 8.148 Saltbr-out 3.969 HRD-in -79.71, -50.4 83.15, -12.3 out-in-none SNCoin in-none ActLoopNT-in 3.061 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -116.55 APE9-dihe-in -116.09, 161.75 APE8-dihe-in -79.75, 74.02 APE8-rot-na 34.39 APE67-dihe-in -47.92, -26.61 -60.2, -39.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.895 APE9-dist-in 7.289 None None None XRAY 2.6 0.2 0.222 A 291 255 12 0 0 4 [[370, 628]] 1.0 3emg TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4FL3A 9 635 635.0 ANP:701 ATPlike Inactive DFGin 5.271 12.411 BLBplus -116.27, 169.06 58.02, 22.77 -60.26, 128.95 39.87, 90.8 70.36, 3.28 out-out out 13.347 Saltbr-out 12.957 HRD-in -71.66, -54.51 80.39, -19.8 out-out-none SNCoon out-none ActLoopNT-out 7.03 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 2.25 APE8-rot-na 29.04 APE67-dihe-in -63.72, -20.72 -59.66, -31.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y348F,Y352F None None XRAY 1.9 0.18 0.208 A 635 538 13 0 0 13 [[370, 628]] 1.0 4fl3 TYR_SYK_HUMAN TYR 5.1e-89 304.2 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4FL2A 9 635 635.0 ANP:702 ATPlike Inactive DFGin 5.428 12.328 BLBplus -115.2, 163.41 55.5, 31.26 -66.72, 128.2 35.56, 90.39 65.72, 13.6 out-out out 13.491 Saltbr-out 13.203 HRD-in -70.05, -49.77 75.03, -15.27 out-out-out SNCooo out-out ActLoopNT-out 7.194 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.16, 144.55 APE9-dihe-in -104.91, 94.8 APE8-dihe-out -50.62, -30.17 APE8-rot-na 333.32 APE67-dihe-in -61.99, -18.29 -62.08, -21.97 APE12-dist-na 15.556 APE11-dist-na 19.206 APE10-dist-na 15.736 APE9-dist-out 11.527 None None None XRAY 2.19 0.184 0.228 A 636 555 0 0 0 0 [[370, 628]] 1.0 4fl2 TYR_SYK_HUMAN TYR 5.1e-89 304.2 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
3TUCA 358 633 635.0 FPW:999 Type1.5_Front Inactive DFGin 6.556 15.019 BLBplus -114.33, 165.27 53.65, 40.82 -73.1, 146.31 90.45, 83.64 -43.15, -55.01 out-out out 11.471 Saltbr-out 7.068 HRD-in -66.05, -58.66 86.11, -25.8 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.49 APE8-rot-na 24.54 APE67-dihe-in -67.39, -16.05 -47.1, -39.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.216 0.285 A 299 257 19 0 0 19 [[370, 628]] 1.0 3tuc TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
3TUBA 362 633 635.0 FPU:999 Type2 Inactive DFGout 13.74 9.67 BBAminus -126.08, 171.13 -141.46, 68.74 -40.79, -49.16 289.47, 103.31 -92.66, 19.79 in-out in 8.316 Saltbr-out 3.667 HRD-in -62.48, -58.18 81.87, -14.31 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 55.79 APE8-rot-na 29.91 APE67-dihe-in -67.44, -14.12 -48.38, -36.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.23 0.182 0.232 A 293 253 19 0 0 19 [[370, 628]] 1.0 3tub TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
3TUDA 363 635 635.0 FPX:60001 Type2 Inactive DFGout 15.309 10.866 None -123.06, 178.93 -154.97, 96.56 -80.58, 999.0 302.91, 174.18 999.0, 999.0 in-in in 8.75 Saltbr-in 2.756 HRD-in -65.87, -59.08 79.62, -13.62 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -60.05, 129.63 APE9-dihe-in -111.2, 153.71 APE8-dihe-in -83.04, 71.46 APE8-rot-na 31.48 APE67-dihe-in -66.5, -12.19 -53.72, -36.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.652 None None None XRAY 2.33 0.198 0.263 A 299 255 18 0 0 18 [[370, 628]] 1.0 3tud TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4XG2A 364 635 635.0 No_ligand No_ligand None DFGin 6.56 14.743 BLAminus -130.24, -178.99 62.72, 77.6 -96.14, 15.75 290.58, 78.21 -62.22, -24.62 in-in in 8.189 Saltbr-in 2.79 HRD-in -76.73, -52.8 72.67, 7.33 in-in-none SNCiin in-none ActLoopNT-in 2.857 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 129.75 APE9-dihe-in -121.46, 135.12 APE8-dihe-in -76.71, 74.12 APE8-rot-na 35.22 APE67-dihe-in -65.91, -17.02 -54.02, -32.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.903 APE9-dist-in 7.056 None None None XRAY 2.21 0.204 0.227 A 290 258 14 0 0 4 [[370, 628]] 1.0 4xg2 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
6HM7A 363 633 635.0 GDH:701 Type1 None DFGin 6.553 14.527 BLAminus -123.85, -179.77 64.31, 73.15 -92.84, 18.31 290.79, 83.99 -60.41, -28.58 in-in in 8.033 Saltbr-in 2.928 HRD-in -76.88, -50.91 71.45, 2.92 in-in-none SNCiin in-none ActLoopNT-in 2.904 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 157.3 APE8-dihe-in -78.81, 69.42 APE8-rot-na 32.62 APE67-dihe-in -63.42, -18.8 -55.15, -34.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.568 None PTR525 PTR525 XRAY 1.64 0.174 0.21 A 276 268 3 0 0 3 [[370, 628]] 1.0 6hm7 TYR_SYK_HUMAN TYR 4.5e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
5LMBB 364 630 635.0 6ZF:701 Type1 None DFGin 6.542 14.207 BLAminus -133.05, -174.7 62.98, 72.21 -97.02, 21.38 290.54, 88.36 -62.52, -32.46 in-in in 7.737 Saltbr-in 2.556 HRD-in -77.26, -52.74 74.6, 8.57 in-in-none SNCiin in-none ActLoopNT-in 2.872 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.43 APE8-dihe-in -80.7, 73.18 APE8-rot-na 30.16 APE67-dihe-in -64.42, -18.25 -49.18, -37.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.948 None PTR525 PTR525 XRAY 1.95 0.178 0.228 B 277 262 5 0 0 5 [[370, 628]] 1.0 5lmb TYR_SYK_HUMAN TYR 4.6e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
8X5KA 363 632 635.0 3YT:701 Type1 None DFGin 6.382 14.656 BLAminus -132.21, -172.26 63.3, 68.78 -95.24, 19.38 292.18, 89.98 -56.7, -30.78 in-in in 7.894 Saltbr-in 2.95 HRD-in -71.77, -56.19 75.58, 0.61 in-in-none SNCiin in-none ActLoopNT-in 2.948 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.95 APE8-rot-na 32.78 APE67-dihe-in -63.64, -18.99 -57.25, -32.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.192 0.244 A 280 264 6 0 0 5 [[370, 628]] 1.0 8x5k TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
6VOVA 363 629 635.0 R6D:701 Type1 None DFGin 6.491 14.551 BLAminus -133.59, -172.02 59.62, 69.16 -89.35, 17.8 288.33, 91.38 -60.0, -27.27 in-in in 7.994 Saltbr-in 2.69 HRD-in -77.79, -51.77 71.65, 6.09 in-in-none SNCiin in-none ActLoopNT-in 2.99 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.03 APE8-dihe-in -78.95, 69.83 APE8-rot-na 28.75 APE67-dihe-in -65.35, -15.72 -44.66, -41.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.197 None None None XRAY 1.95 0.22 0.268 A 281 258 9 0 0 4 [[370, 628]] 1.0 6vov TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
8RRZA 363 633 635.0 A1H2Y:701 Type1 None DFGin 6.461 14.682 BLAminus -127.74, -179.45 67.79, 70.28 -94.76, 22.67 287.65, 98.81 -62.91, -34.06 in-in in 7.964 Saltbr-in 2.897 HRD-in -78.47, -50.78 73.26, 5.22 in-in-none SNCiin in-none ActLoopNT-in 2.939 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.18 APE8-dihe-in -75.14, 72.0 APE8-rot-na 32.71 APE67-dihe-in -61.9, -17.04 -54.99, -37.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.332 None PTR525,PTR526 PTR525,PTR526 XRAY 1.75 0.182 0.214 A 282 262 9 0 0 4 [[370, 628]] 1.0 8rrz TYR_SYK_HUMAN TYR 4.9e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
5TR6A 362 635 635.0 7KG:60701 Type1 None DFGin 6.42 14.422 BLAminus -132.48, 179.72 59.87, 74.11 -95.94, 22.5 287.39, 87.93 -67.35, -26.8 in-none in 7.993 Saltbr-none 999.0 HRD-in -77.83, -50.78 68.92, 14.83 none-in-in SNCnii in-in ActLoopNT-in 2.921 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.28, 93.77 APE9-dihe-in -107.16, 142.31 APE8-dihe-in -78.63, 77.12 APE8-rot-na 32.22 APE67-dihe-in -65.12, -14.48 -58.58, -35.04 APE12-dist-na 13.682 APE11-dist-na 10.164 APE10-dist-na 10.507 APE9-dist-in 6.975 None None None XRAY 1.93 0.195 0.217 A 289 268 6 0 0 0 [[370, 628]] 1.0 5tr6 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4XG3B 363 633 635.0 X3G:701 Type1 None DFGin 6.361 14.26 BLAminus -128.52, -176.24 59.83, 77.98 -95.46, 17.98 292.06, 88.72 -55.83, -35.07 in-in in 7.757 Saltbr-in 2.713 HRD-in -74.45, -44.97 66.32, 3.24 in-in-none SNCiin in-none ActLoopNT-in 3.038 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 60.87 APE9-dihe-in -106.83, 127.91 APE8-dihe-in -75.62, 80.4 APE8-rot-na 32.03 APE67-dihe-in -68.27, -18.81 -58.02, -33.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.758 APE9-dist-in 7.133 None None None XRAY 2.3 0.199 0.226 B 290 267 4 0 0 4 [[370, 628]] 1.0 4xg3 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4XG4A 363 635 635.0 X4G:701 Type1 None DFGin 6.633 14.5 BLAminus -121.07, 179.74 64.97, 74.28 -96.12, 21.86 293.04, 85.88 -61.26, -26.24 in-in in 7.936 Saltbr-in 2.671 HRD-in -75.83, -50.72 70.19, 14.15 in-in-none SNCiin in-none ActLoopNT-in 2.933 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 92.08 APE9-dihe-in -117.97, 139.01 APE8-dihe-in -75.6, 78.94 APE8-rot-na 30.7 APE67-dihe-in -67.4, -20.31 -55.84, -33.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.903 APE9-dist-in 7.112 None None None XRAY 2.3 0.195 0.228 A 290 264 9 0 0 4 [[370, 628]] 1.0 4xg4 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4XG6A 363 635 635.0 X6G:60701 Type1 None DFGin 6.254 14.314 BLAminus -118.6, -179.8 61.85, 86.51 -104.68, 19.31 297.54, 90.69 -53.97, -29.58 in-in in 7.848 Saltbr-in 2.675 HRD-in -72.81, -51.23 73.7, 7.07 in-in-none SNCiin in-none ActLoopNT-in 2.908 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -1.44 APE8-rot-na 30.73 APE67-dihe-in -63.62, -23.47 -57.96, -32.34 APE12-dist-na 11.58 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.192 0.23 A 290 270 3 0 0 3 [[370, 628]] 1.0 4xg6 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4XG8C 364 629 635.0 X8G:700 Type1 None DFGin 6.369 14.266 BLAminus -112.98, -178.28 65.43, 72.58 -97.08, 19.7 293.26, 93.71 -69.16, -21.23 in-in in 8.045 Saltbr-in 2.925 HRD-in -74.14, -54.5 72.61, 6.51 in-in-none SNCiin in-none ActLoopNT-in 2.709 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 27.72 APE8-rot-na 24.07 APE67-dihe-in -75.25, -15.23 -58.44, -32.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.249 0.275 C 290 254 12 0 0 5 [[370, 628]] 1.0 4xg8 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4XG9A 363 632 635.0 X9G:700 Type1 None DFGin 6.388 14.253 BLAminus -123.44, -179.44 57.72, 74.85 -93.27, 25.8 301.09, 93.35 -61.2, -36.75 in-in in 7.964 Saltbr-in 2.623 HRD-in -74.42, -57.7 72.94, 15.94 in-in-none SNCiin in-none ActLoopNT-in 2.787 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 14.65 APE8-rot-na 19.29 APE67-dihe-in -69.72, -24.67 -61.87, -28.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.91 0.21 0.241 A 290 259 11 0 0 6 [[370, 628]] 1.0 4xg9 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4XG9B 363 634 635.0 X9G:700 Type1 None DFGin 6.347 14.216 BLAminus -128.68, -177.25 53.27, 77.68 -95.83, 18.82 297.69, 92.87 -61.29, -26.93 in-in in 7.968 Saltbr-in 2.503 HRD-in -72.55, -56.82 71.48, 16.81 in-in-none SNCiin in-none ActLoopNT-in 2.833 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 14.58 APE8-rot-na 27.68 APE67-dihe-in -67.7, -23.41 -54.17, -35.6 APE12-dist-na 11.89 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.91 0.21 0.241 B 290 265 7 0 0 3 [[370, 628]] 1.0 4xg9 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
5GHVA 363 635 635.0 X5G:701 Type1 None DFGin 6.51 14.486 BLAminus -121.34, 177.94 62.19, 88.65 -109.69, 41.48 296.98, 84.28 -77.6, -32.83 in-in in 8.11 Saltbr-in 2.732 HRD-in -76.16, -59.71 78.21, 9.71 in-in-none SNCiin in-none ActLoopNT-in 2.964 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 59.75 APE9-dihe-in -134.2, 142.35 APE8-dihe-in -78.13, 86.38 APE8-rot-na 29.33 APE67-dihe-in -64.76, -25.26 -61.51, -32.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.668 APE9-dist-in 7.398 None None None XRAY 2.8 0.217 0.227 A 290 265 8 0 0 4 [[370, 628]] 1.0 5ghv TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
5GHVB 363 635 635.0 X5G:701 Type1 None DFGin 6.495 14.39 BLAminus -125.29, 176.55 63.13, 89.9 -112.44, 39.0 296.07, 82.84 -75.29, -45.81 in-in in 8.074 Saltbr-in 2.715 HRD-in -75.16, -55.76 75.92, 10.79 in-in-none SNCiin in-none ActLoopNT-in 3.094 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 48.46 APE9-dihe-in -133.95, 133.36 APE8-dihe-in -79.51, 91.82 APE8-rot-na 28.71 APE67-dihe-in -66.71, -23.44 -67.07, -29.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.251 APE9-dist-in 7.569 None None None XRAY 2.8 0.217 0.227 B 290 265 8 0 0 4 [[370, 628]] 1.0 5ghv TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
8XQ0B 364 634 635.0 A1LV4:701 Type1 None DFGin 6.294 14.269 BLAminus -121.56, -165.09 54.01, 77.14 -98.56, 23.24 296.48, 92.65 -61.88, -28.43 in-in in 8.418 Saltbr-in 2.649 HRD-in -77.64, -48.09 70.42, 13.58 in-in-none SNCiin in-none ActLoopNT-in 2.796 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 110.46 APE9-dihe-in -140.12, 100.43 APE8-dihe-in -73.17, 75.7 APE8-rot-na 30.62 APE67-dihe-in -68.44, -13.24 -66.75, -26.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.655 APE9-dist-in 6.875 None None None XRAY 1.95 0.222 0.265 B 290 253 18 0 0 4 [[370, 628]] 1.0 8xq0 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
8XQ0D 364 635 635.0 A1LV4:701 Type1 None DFGin 6.314 14.39 BLAminus -120.19, -170.79 65.2, 70.98 -95.79, 24.62 295.16, 93.42 -63.39, -28.44 in-in in 8.488 Saltbr-in 2.701 HRD-in -76.01, -49.61 70.34, 8.1 in-in-none SNCiin in-none ActLoopNT-in 2.787 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 140.86 APE9-dihe-in -154.41, 100.57 APE8-dihe-in -72.25, 67.88 APE8-rot-na 28.73 APE67-dihe-in -63.58, -17.28 -53.94, -36.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.164 APE9-dist-in 6.963 None None None XRAY 1.95 0.222 0.265 D 290 258 14 0 0 4 [[370, 628]] 1.0 8xq0 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
8XQ1A 364 634 635.0 A1LV6:901 Type1 None DFGin 6.301 14.482 BLAminus -124.74, -173.52 66.63, 71.35 -96.63, 19.35 289.84, 89.05 -66.02, -25.46 in-in in 8.266 Saltbr-in 2.817 HRD-in -80.15, -50.35 70.61, 8.83 in-in-none SNCiin in-none ActLoopNT-in 2.96 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 134.1 APE9-dihe-in -110.96, 150.88 APE8-dihe-in -81.12, 69.26 APE8-rot-na 30.82 APE67-dihe-in -65.34, -12.5 -60.05, -31.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.595 APE9-dist-in 7.086 None None None XRAY 1.5 0.188 0.209 A 290 263 8 0 0 3 [[370, 628]] 1.0 8xq1 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
8XQ1B 364 634 635.0 A1LV6:901 Type1 None DFGin 6.306 14.438 BLAminus -122.4, -173.86 66.54, 73.25 -99.1, 21.97 289.94, 89.92 -65.7, -26.72 in-in in 8.205 Saltbr-in 2.828 HRD-in -76.67, -51.02 71.1, 10.17 in-in-none SNCiin in-none ActLoopNT-in 2.981 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 119.35 APE9-dihe-in -109.54, 149.84 APE8-dihe-in -80.64, 68.82 APE8-rot-na 32.7 APE67-dihe-in -66.82, -12.34 -64.74, -24.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.364 APE9-dist-in 7.112 None None None XRAY 1.5 0.188 0.209 B 290 263 8 0 0 3 [[370, 628]] 1.0 8xq1 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
8XQ2A 363 634 635.0 A1LV7:802 Type1 None DFGin 6.366 14.425 BLAminus -126.78, -178.48 65.06, 70.63 -92.55, 21.67 293.19, 85.55 -66.06, -22.05 in-in in 8.341 Saltbr-in 2.829 HRD-in -77.37, -51.66 73.37, 4.48 in-in-none SNCiin in-none ActLoopNT-in 2.903 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 83.79 APE8-rot-na 27.63 APE67-dihe-in -66.2, -13.18 -59.95, -35.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.206 0.238 A 290 263 9 0 0 4 [[370, 628]] 1.0 8xq2 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
8XQ2B 364 632 635.0 A1LV7:701 Type1 None DFGin 6.407 14.57 BLAminus -126.32, -176.03 64.56, 73.36 -94.65, 19.7 292.4, 83.49 -62.95, -22.08 in-in in 8.283 Saltbr-in 2.921 HRD-in -78.79, -49.2 70.93, 7.72 in-in-none SNCiin in-none ActLoopNT-in 2.952 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 81.5 APE9-dihe-in -124.35, 129.64 APE8-dihe-in -71.15, 79.1 APE8-rot-na 29.02 APE67-dihe-in -66.5, -10.69 -61.42, -32.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.75 APE9-dist-in 6.84 None None None XRAY 1.8 0.206 0.238 B 290 261 8 0 0 2 [[370, 628]] 1.0 8xq2 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
1XBBA 363 635 635.0 STI:60001 Type1 None DFGin 6.664 14.623 BLAminus -128.05, 176.75 68.38, 79.08 -100.61, 19.15 290.6, 90.35 -58.48, -28.27 in-in in 8.236 Saltbr-in 3.032 HRD-in -76.13, -51.62 74.69, 4.56 in-in-none SNCiin in-none ActLoopNT-in 2.878 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 178.76 APE9-dihe-in -111.48, 137.0 APE8-dihe-in -74.08, 70.57 APE8-rot-na 29.87 APE67-dihe-in -65.65, -14.73 -52.2, -36.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.126 APE9-dist-in 7.2 None None None XRAY 1.57 0.191 0.221 A 291 264 9 0 0 4 [[370, 628]] 1.0 1xbb TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
3FQEA 363 635 635.0 P5C:60001 Type1 None DFGin 6.241 14.552 BLAminus -134.09, -160.32 61.99, 71.61 -98.66, 22.24 289.6, 83.21 -60.61, -25.52 in-in in 8.249 Saltbr-in 3.362 HRD-in -87.09, -50.31 69.38, 7.86 in-in-none SNCiin in-none ActLoopNT-in 2.953 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 126.45 APE9-dihe-in -122.15, 142.06 APE8-dihe-in -70.06, 69.94 APE8-rot-na 27.41 APE67-dihe-in -70.93, -8.12 -53.23, -38.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.212 APE9-dist-in 7.072 None None None XRAY 2.5 0.203 0.253 A 291 265 8 0 0 3 [[370, 628]] 1.0 3fqe TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
3FQHB 363 633 635.0 057:2 Type1 None DFGin 6.512 14.384 BLAminus -135.61, -177.0 61.05, 83.05 -100.81, 28.19 289.97, 93.91 -68.13, -27.21 in-in in 7.95 Saltbr-in 2.929 HRD-in -70.78, -57.98 73.35, 4.27 in-in-none SNCiin in-none ActLoopNT-in 2.946 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 140.44 APE9-dihe-in -122.67, 149.45 APE8-dihe-in -71.04, 64.02 APE8-rot-na 27.55 APE67-dihe-in -70.95, -10.14 -42.56, -38.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.931 APE9-dist-in 7.058 None None None XRAY 2.26 0.216 0.259 B 291 258 13 0 0 4 [[370, 628]] 1.0 3fqh TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
3FQSA 363 635 635.0 585:60001 Type1 None DFGin 6.671 15.119 BLAminus -130.1, -168.06 51.07, 81.04 -99.05, 21.72 287.94, 89.19 -65.06, -25.56 in-in in 8.251 Saltbr-in 2.89 HRD-in -73.57, -53.38 73.0, 6.23 in-in-none SNCiin in-none ActLoopNT-in 2.927 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 124.94 APE9-dihe-in -106.74, 133.78 APE8-dihe-in -71.17, 66.53 APE8-rot-na 27.84 APE67-dihe-in -63.27, -16.28 -46.11, -40.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.716 APE9-dist-in 7.49 None None None XRAY 2.1 0.218 0.253 A 291 264 9 0 0 4 [[370, 628]] 1.0 3fqs TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4FYNA 363 635 635.0 0VE:60701 Type1 None DFGin 6.322 14.552 BLAminus -125.05, -173.65 56.58, 84.17 -104.44, 22.0 295.83, 84.03 -64.28, -16.7 in-in in 8.168 Saltbr-in 2.747 HRD-in -77.65, -54.89 74.1, 7.86 in-in-none SNCiin in-none ActLoopNT-in 2.924 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 150.74 APE9-dihe-in -119.38, 130.75 APE8-dihe-in -71.21, 75.44 APE8-rot-na 25.91 APE67-dihe-in -62.88, -14.32 -62.84, -38.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.751 APE9-dist-in 7.34 None None None XRAY 2.318 0.228 0.269 A 291 263 10 0 0 4 [[370, 628]] 1.0 4fyn TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4FYOA 363 635 635.0 0VF:60701 Type1 None DFGin 6.527 14.676 BLAminus -132.65, -177.95 62.23, 72.42 -93.99, 21.12 289.45, 90.18 -61.07, -25.58 in-in in 7.75 Saltbr-in 2.757 HRD-in -74.26, -50.97 72.76, 4.05 in-in-none SNCiin in-none ActLoopNT-in 2.952 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 140.05 APE9-dihe-in -108.11, 144.2 APE8-dihe-in -76.07, 73.27 APE8-rot-na 27.85 APE67-dihe-in -65.29, -14.44 -52.41, -38.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.947 APE9-dist-in 7.308 None None None XRAY 1.4 0.22 0.24 A 291 263 10 0 0 4 [[370, 628]] 1.0 4fyo TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4FZ6A 363 635 635.0 0VG:60701 Type1 None DFGin 6.317 14.691 BLAminus -133.65, -169.74 58.51, 78.15 -100.44, 26.78 291.45, 90.91 -64.04, -31.24 in-in in 8.443 Saltbr-in 3.006 HRD-in -75.46, -52.97 71.45, 4.73 in-in-none SNCiin in-none ActLoopNT-in 2.901 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 139.2 APE9-dihe-in -115.79, 143.14 APE8-dihe-in -76.09, 69.74 APE8-rot-na 28.85 APE67-dihe-in -66.47, -14.43 -53.02, -38.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.466 APE9-dist-in 7.234 None None None XRAY 1.85 0.23 0.253 A 291 262 11 0 0 4 [[370, 628]] 1.0 4fz6 TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4FZ7A 363 635 635.0 0VH:60701 Type1 None DFGin 6.4 14.413 BLAminus -130.24, -170.94 63.54, 68.16 -91.78, 16.19 289.77, 87.77 -59.49, -25.0 in-in in 8.219 Saltbr-in 2.95 HRD-in -74.99, -52.16 71.67, 6.11 in-in-none SNCiin in-none ActLoopNT-in 2.877 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 93.82 APE9-dihe-in -107.75, 152.66 APE8-dihe-in -78.57, 65.92 APE8-rot-na 31.11 APE67-dihe-in -66.21, -17.27 -45.73, -35.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.607 APE9-dist-in 6.901 None None None XRAY 1.75 0.202 0.25 A 291 261 12 0 0 4 [[370, 628]] 1.0 4fz7 TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4I0RA 363 635 635.0 1B4:60701 Type1 None DFGin 6.303 14.472 BLAminus -120.7, -175.74 66.13, 76.03 -99.52, 27.66 293.49, 90.9 -68.19, -27.87 in-in in 8.079 Saltbr-in 2.795 HRD-in -77.52, -55.13 72.71, 3.63 in-in-none SNCiin in-none ActLoopNT-in 2.856 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 132.26 APE9-dihe-in -103.47, 139.74 APE8-dihe-in -70.94, 75.19 APE8-rot-na 28.76 APE67-dihe-in -61.34, -17.47 -59.11, -38.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.727 APE9-dist-in 7.158 None None None XRAY 2.1 0.237 0.272 A 291 260 13 0 0 4 [[370, 628]] 1.0 4i0r TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4I0SA 363 635 635.0 1B5:60701 Type1 None DFGin 6.348 14.318 BLAminus -129.27, -175.27 55.43, 83.6 -98.08, 24.19 289.58, 86.12 -61.12, -27.32 in-in in 8.034 Saltbr-in 2.589 HRD-in -71.15, -52.29 70.43, 7.1 in-in-none SNCiin in-none ActLoopNT-in 2.926 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 126.23 APE9-dihe-in -113.12, 145.51 APE8-dihe-in -74.21, 66.56 APE8-rot-na 27.25 APE67-dihe-in -64.4, -15.49 -48.66, -38.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.673 APE9-dist-in 7.239 None None None XRAY 1.98 0.218 0.236 A 291 263 10 0 0 4 [[370, 628]] 1.0 4i0s TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4PUZA 363 633 635.0 CG9:701 Type1 None DFGin 6.367 14.29 BLAminus -136.54, -176.83 63.98, 77.0 -97.69, 30.02 296.24, 87.49 -65.1, -31.87 in-in in 7.929 Saltbr-in 2.822 HRD-in -73.68, -57.13 77.44, 4.88 in-in-none SNCiin in-none ActLoopNT-in 2.806 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 106.61 APE9-dihe-in -123.49, 140.78 APE8-dihe-in -68.55, 53.64 APE8-rot-na 28.04 APE67-dihe-in -67.84, -11.38 -28.81, -44.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.915 APE9-dist-in 7.237 None None None XRAY 2.085 0.213 0.261 A 291 263 8 0 0 3 [[370, 628]] 1.0 4puz TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4PUZB 363 635 635.0 CG9:701 Type1 None DFGin 6.303 14.273 BLAminus -130.49, 178.11 63.06, 88.54 -109.96, 27.3 298.33, 92.7 -70.91, -20.76 in-in in 7.815 Saltbr-in 2.905 HRD-in -68.83, -56.51 73.59, 10.98 in-in-none SNCiin in-none ActLoopNT-in 2.679 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 100.98 APE9-dihe-in -104.75, 136.54 APE8-dihe-in -73.52, 61.27 APE8-rot-na 28.37 APE67-dihe-in -69.59, -18.44 -38.04, -42.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.414 APE9-dist-in 6.976 None None None XRAY 2.085 0.213 0.261 B 291 265 8 0 0 3 [[370, 628]] 1.0 4puz TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
5T68A 363 635 635.0 77V:60701 Type1 None DFGin 6.399 14.233 BLAminus -118.2, -175.03 55.02, 90.22 -105.11, 31.93 294.35, 102.52 -80.93, -22.27 in-in in 7.864 Saltbr-in 2.767 HRD-in -79.38, -47.76 69.54, -3.58 in-in-none SNCiin in-none ActLoopNT-in 3.07 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -53.8 APE9-dihe-in -121.95, 75.31 APE8-dihe-in -77.88, 51.45 APE8-rot-na 19.76 APE67-dihe-in -78.2, -26.54 -39.48, -21.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.291 APE9-dist-in 7.587 None None None XRAY 2.93 0.188 0.281 A 291 264 9 0 0 4 [[370, 628]] 1.0 5t68 TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
5T68B 363 635 635.0 77V:60701 Type1 None DFGin 6.335 14.549 BLAminus -125.81, -173.18 53.62, 72.36 -90.46, 31.38 289.78, 97.36 -69.64, -47.12 in-in in 7.859 Saltbr-in 2.795 HRD-in -56.8, -40.48 64.3, -8.06 in-in-none SNCiin in-none ActLoopNT-in 2.996 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -66.53 APE9-dihe-in -122.76, 73.0 APE8-dihe-in -76.02, 70.05 APE8-rot-na 29.83 APE67-dihe-in -58.48, -8.81 -36.73, -49.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.244 APE9-dist-in 6.86 None None None XRAY 2.93 0.188 0.281 B 291 264 9 0 0 4 [[370, 628]] 1.0 5t68 TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
5Y5UB 363 629 635.0 8OU:701 Type1 None DFGin 6.322 13.999 BLAminus -136.83, 172.48 60.12, 69.06 -76.3, 17.06 301.14, 79.7 -45.71, -46.86 in-in in 7.647 Saltbr-in 2.798 HRD-in -72.89, -51.34 74.65, -2.0 in-in-none SNCiin in-none ActLoopNT-in 2.821 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 45.91 APE8-rot-na 27.44 APE67-dihe-in -59.42, -23.8 -55.69, -38.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.14 0.239 0.26 B 293 257 10 0 0 6 [[370, 628]] 1.0 5y5u TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
8WYWA 364 633 635.0 XFB:701 Type1 None DFGin 6.237 14.467 BLAminus -132.59, -164.71 66.23, 68.08 -96.88, 23.52 293.79, 90.86 -58.6, -30.92 in-in in 8.046 Saltbr-in 2.8 HRD-in -78.12, -54.08 75.86, 6.55 in-in-none SNCiin in-none ActLoopNT-in 2.953 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 61.34 APE8-rot-na 31.52 APE67-dihe-in -65.01, -13.06 -58.71, -34.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.202 0.242 A 293 264 6 0 0 6 [[370, 628]] 1.0 8wyw TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
8WYWB 365 633 635.0 XFB:701 Type1 None DFGin 6.298 14.432 BLAminus -136.18, -166.23 64.92, 68.41 -94.85, 24.26 293.81, 88.05 -62.54, -27.54 in-in in 8.1 Saltbr-in 2.762 HRD-in -75.21, -53.42 72.9, 5.68 in-in-none SNCiin in-none ActLoopNT-in 2.97 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 56.28 APE8-rot-na 30.56 APE67-dihe-in -70.56, -10.12 -50.08, -35.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.202 0.242 B 293 263 6 0 0 6 [[370, 628]] 1.0 8wyw TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
3VF8A 363 635 635.0 0JE:701 Type1 None DFGin 6.303 14.274 BLAminus -127.47, -170.59 55.16, 83.49 -101.53, 21.98 288.96, 89.41 -58.75, -35.76 in-none in 8.043 Saltbr-none 999.0 HRD-in -73.27, -51.41 67.21, 6.99 none-in-in SNCnii in-in ActLoopNT-in 2.985 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.14, 90.57 APE9-dihe-in -105.62, 138.03 APE8-dihe-in -81.27, 73.81 APE8-rot-na 26.23 APE67-dihe-in -66.47, -16.98 -51.38, -34.52 APE12-dist-na 13.257 APE11-dist-na 10.092 APE10-dist-na 10.007 APE9-dist-in 6.796 None None None XRAY 2.08 0.217 0.241 A 299 265 8 0 0 0 [[370, 628]] 1.0 3vf8 TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
3VF9A 364 635 635.0 477:701 Type1 None DFGin 6.396 14.64 BLAminus -128.07, -174.94 57.37, 81.54 -100.98, 31.05 291.59, 91.29 -68.94, -37.68 in-none in 7.996 Saltbr-none 999.0 HRD-in -72.91, -49.87 65.85, 9.08 none-in-in SNCnii in-in ActLoopNT-in 3.023 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.57, 94.78 APE9-dihe-in -116.96, 141.01 APE8-dihe-in -83.94, 81.53 APE8-rot-na 20.28 APE67-dihe-in -58.58, -19.75 -44.92, -48.84 APE12-dist-na 13.207 APE11-dist-na 10.508 APE10-dist-na 9.877 APE9-dist-in 6.696 None None None XRAY 2.3 0.255 0.267 A 299 265 7 0 0 0 [[370, 628]] 1.0 3vf9 TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
6SSBA 363 635 635.0 LUE:60701 Type1 None DFGin 6.592 14.467 BLAminus -122.14, -172.72 60.63, 82.61 -104.23, 21.05 289.2, 91.73 -65.13, -29.21 in-in in 8.322 Saltbr-in 2.938 HRD-in -79.93, -48.97 63.18, 12.69 in-in-none SNCiin in-none ActLoopNT-in 2.83 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 141.28 APE9-dihe-in -123.27, 130.6 APE8-dihe-in -78.29, 70.91 APE8-rot-na 28.49 APE67-dihe-in -60.55, -20.65 -51.68, -36.02 APE12-dist-na 13.355 APE11-dist-na 999.0 APE10-dist-na 11.696 APE9-dist-in 7.598 None None None XRAY 2.08 0.198 0.225 A 299 265 8 0 0 1 [[370, 628]] 1.0 6ssb TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
6ZCQA 363 635 635.0 QFB:60701 Type1 None DFGin 6.284 14.2 BLAminus -124.06, -169.43 66.04, 72.78 -96.7, 17.81 287.27, 83.52 -60.89, -32.14 in-in in 7.992 Saltbr-in 2.987 HRD-in -74.82, -45.46 62.85, 5.49 in-in-none SNCiin in-none ActLoopNT-in 2.786 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 48.57 APE9-dihe-in -117.91, 130.07 APE8-dihe-in -75.75, 81.23 APE8-rot-na 23.59 APE67-dihe-in -67.53, -16.63 -56.17, -31.85 APE12-dist-na 13.343 APE11-dist-na 999.0 APE10-dist-na 10.663 APE9-dist-in 7.588 None None None XRAY 2.32 0.191 0.244 A 299 265 8 0 0 1 [[370, 628]] 1.0 6zcq TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
6ZCRA 363 635 635.0 5JG:60701 Type1 None DFGin 6.691 14.616 BLAminus -131.25, -174.99 58.52, 82.29 -98.4, 23.45 287.56, 81.54 -60.43, -25.78 in-in in 8.005 Saltbr-in 2.921 HRD-in -78.76, -53.73 70.25, 7.39 in-in-none SNCiin in-none ActLoopNT-in 2.804 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.61 APE8-dihe-in -81.67, 70.3 APE8-rot-na 33.8 APE67-dihe-in -65.02, -14.57 -49.04, -40.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.715 None None None XRAY 1.73 0.189 0.218 A 299 264 9 0 0 4 [[370, 628]] 1.0 6zcr TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
6ZCSA 363 635 635.0 QFE:60701 Type1 None DFGin 6.423 14.516 BLAminus -134.38, -165.15 61.58, 75.97 -101.01, 19.73 286.51, 84.39 -60.24, -29.14 in-in in 8.086 Saltbr-in 2.967 HRD-in -75.9, -52.9 70.28, 10.24 in-in-none SNCiin in-none ActLoopNT-in 2.953 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 129.22 APE9-dihe-in -113.36, 141.08 APE8-dihe-in -78.2, 72.25 APE8-rot-na 29.63 APE67-dihe-in -66.52, -13.86 -50.21, -39.33 APE12-dist-na 13.375 APE11-dist-na 999.0 APE10-dist-na 11.307 APE9-dist-in 7.092 None None None XRAY 1.47 0.191 0.208 A 299 267 6 0 0 1 [[370, 628]] 1.0 6zcs TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
6ZCUA 363 635 635.0 5JG:60701 Type1 None DFGin 6.691 14.616 BLAminus -131.25, -174.99 58.52, 82.29 -98.4, 23.45 287.56, 81.54 -60.43, -25.78 in-in in 8.005 Saltbr-in 2.921 HRD-in -78.76, -53.73 70.25, 7.39 in-in-none SNCiin in-none ActLoopNT-in 2.804 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.61 APE8-dihe-in -81.67, 70.3 APE8-rot-na 33.8 APE67-dihe-in -65.02, -14.57 -49.04, -40.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.715 None None None XRAY 1.73 0.189 0.218 A 299 264 9 0 0 4 [[370, 628]] 1.0 6zcu TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
6ZCXA 363 635 635.0 QFQ:60701 Type1 None DFGin 6.394 14.216 BLAminus -127.67, -173.55 62.06, 69.93 -92.28, 16.27 287.89, 90.74 -57.86, -30.2 in-in in 7.981 Saltbr-in 2.76 HRD-in -77.57, -48.61 68.8, 7.96 in-in-none SNCiin in-none ActLoopNT-in 2.865 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 153.3 APE9-dihe-in -109.71, 136.91 APE8-dihe-in -79.72, 69.78 APE8-rot-na 28.01 APE67-dihe-in -63.91, -15.97 -45.91, -39.08 APE12-dist-na 13.354 APE11-dist-na 999.0 APE10-dist-na 11.597 APE9-dist-in 7.167 None None None XRAY 1.66 0.191 0.229 A 299 263 10 0 0 1 [[370, 628]] 1.0 6zcx TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
6ZCYA 363 635 635.0 QF8:60701 Type1 None DFGin 6.387 14.192 BLAminus -129.73, -170.79 60.52, 70.48 -91.88, 15.3 287.22, 87.41 -58.42, -30.07 in-in in 7.93 Saltbr-in 2.768 HRD-in -74.39, -48.85 68.77, 6.76 in-in-none SNCiin in-none ActLoopNT-in 2.961 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 129.7 APE9-dihe-in -121.42, 129.82 APE8-dihe-in -80.2, 74.63 APE8-rot-na 27.78 APE67-dihe-in -63.99, -16.94 -49.51, -37.22 APE12-dist-na 13.978 APE11-dist-na 999.0 APE10-dist-na 10.367 APE9-dist-in 7.055 None None None XRAY 1.81 0.19 0.223 A 299 263 10 0 0 1 [[370, 628]] 1.0 6zcy TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
8BI2A 363 635 635.0 QR7:60701 Type1 None DFGin 6.391 14.35 BLAminus -125.08, -171.04 64.92, 73.8 -98.47, 21.21 291.51, 90.98 -64.58, -29.05 in-in in 8.176 Saltbr-in 2.889 HRD-in -78.14, -51.69 70.22, 11.64 in-in-none SNCiin in-none ActLoopNT-in 2.905 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 81.28 APE9-dihe-in -115.01, 139.63 APE8-dihe-in -80.07, 71.09 APE8-rot-na 29.24 APE67-dihe-in -64.38, -13.13 -46.76, -40.63 APE12-dist-na 12.701 APE11-dist-na 999.0 APE10-dist-na 9.938 APE9-dist-in 7.007 None None None XRAY 1.508 0.205 0.235 A 299 264 9 0 0 1 [[370, 628]] 1.0 8bi2 TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
5CXZA 363 635 635.0 55U:60703 Type1 None DFGin 6.539 14.365 BLAminus -122.74, -171.85 60.83, 74.48 -94.07, 15.61 289.21, 94.41 -56.97, -30.72 in-in in 7.953 Saltbr-in 2.818 HRD-in -72.21, -54.6 71.31, 11.0 in-in-none SNCiin in-none ActLoopNT-in 2.994 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 104.14 APE9-dihe-in -107.14, 142.58 APE8-dihe-in -80.12, 71.68 APE8-rot-na 30.9 APE67-dihe-in -65.83, -15.68 -54.56, -35.41 APE12-dist-na 13.509 APE11-dist-na 999.0 APE10-dist-na 11.349 APE9-dist-in 7.132 K467T None None XRAY 1.7 0.195 0.208 A 289 267 6 0 0 1 [[370, 628]] 1.0 5cxz TYR_SYK_HUMAN TYR 3.9e-90 307.6 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
4PX6A 364 635 635.0 2X6:60701 Type1 None DFGin 6.596 14.557 BLAminus -133.62, -172.86 59.0, 67.69 -88.07, 18.86 287.15, 91.9 -59.4, -27.39 in-in in 7.764 Saltbr-in 2.803 HRD-in -78.31, -51.2 71.98, 5.54 in-in-none SNCiin in-none ActLoopNT-in 2.934 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 131.68 APE9-dihe-in -102.64, 145.76 APE8-dihe-in -78.83, 69.49 APE8-rot-na 28.48 APE67-dihe-in -64.5, -16.03 -45.05, -41.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.958 APE9-dist-in 7.353 K467T None None XRAY 1.6 0.176 0.202 A 291 261 11 0 0 4 [[370, 628]] 1.0 4px6 TYR_SYK_HUMAN TYR 4e-90 307.6 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK

TYR_SYK (Tyrosine-protein kinase SYK)

Total number of chains: 103
Active chains: 36
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 98 95.1% AF-P43405-K1A
DFGin BLBplus 3 2.9% 4FL2A
DFGout BBAminus 1 1.0% 3TUBA
DFGout None 1 1.0% 3TUDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
KSYK_HUMAN 4FL1A P43405 363 635 635.0 ANP:701 ATPlike Active DFGin 6.669 15.063 BLAminus -122.6, -175.53 56.16, 78.38 -92.62, 24.67 287.04, 93.75 -57.67, -38.36 in-in in 8.059 Saltbr-in 2.683 HRD-in -76.27, -50.57 71.77, 3.28 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.55, 85.11 APE9-dihe-in -99.28, 138.37 APE8-dihe-in -79.64, 69.72 APE8-rot-na 29.68 APE67-dihe-in -60.65, -16.95 -44.16, -41.68 APE12-dist-na 13.816 APE11-dist-na 10.806 APE10-dist-na 10.412 APE9-dist-in 7.132 None None None XRAY 1.79 0.197 0.225 A 291 268 5 0 0 0 [[370, 628]] 1.0 4fl1 Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN AF-P43405-K1A P43405 362 635 635.0 No_ligand No_ligand Active DFGin 6.555 14.283 BLAminus -139.44, 178.99 59.92, 76.86 -92.13, 11.74 288.31, 88.77 -62.73, -28.38 in-in in 8.295 Saltbr-in 2.65 HRD-in -79.06, -42.92 61.69, 3.61 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.91, 86.51 APE9-dihe-in -86.43, 140.76 APE8-dihe-in -76.46, 66.17 APE8-rot-na 36.18 APE67-dihe-in -68.53, -16.84 -44.81, -36.23 APE12-dist-na 14.082 APE11-dist-na 9.867 APE10-dist-na 10.621 APE9-dist-in 6.953 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[370, 628]] 1.0 AF-P43405-K1 Homo sapiens TYR_SYK_HUMAN TYR 4.4e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN AF-P43405-K3A P43405 362 635 635.0 No_ligand No_ligand Active DFGin 6.251 14.422 BLAminus -144.99, -179.8 59.41, 72.04 -85.9, 11.12 288.49, 84.65 -61.31, -25.31 in-in in 8.477 Saltbr-in 2.702 HRD-in -76.05, -44.23 63.83, -5.43 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.2, 83.8 APE9-dihe-in -94.84, 151.9 APE8-dihe-in -77.3, 64.33 APE8-rot-na 36.0 APE67-dihe-in -67.48, -13.27 -45.03, -34.91 APE12-dist-na 14.354 APE11-dist-na 10.318 APE10-dist-na 11.565 APE9-dist-in 7.192 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[370, 628]] 1.0 AF-P43405-K3 Homo sapiens TYR_SYK_HUMAN TYR 4.4e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 1XBAA P43405 363 635 635.0 No_ligand No_ligand Active DFGin 6.283 14.388 BLAminus -126.49, -176.52 55.21, 85.12 -100.47, 21.0 289.26, 85.99 -66.46, -29.63 in-in in 7.924 Saltbr-in 3.28 HRD-in -79.13, -52.49 65.3, 12.61 in-in-in SNCiii in-in ActLoopNT-in 2.769 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.47, 98.05 APE9-dihe-in -115.59, 139.53 APE8-dihe-in -72.13, 70.06 APE8-rot-na 26.48 APE67-dihe-in -72.34, -11.74 -55.87, -33.02 APE12-dist-na 13.371 APE11-dist-na 9.536 APE10-dist-na 9.885 APE9-dist-in 6.476 None None None XRAY 2.0 0.231 0.278 A 291 265 8 0 0 0 [[370, 628]] 1.0 1xba Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4F4PA P43405 365 635 635.0 0SB:60701 Type1 Active DFGin 6.373 14.539 BLAminus -124.15, 178.53 62.38, 80.95 -106.72, 25.8 293.21, 86.39 -66.32, -31.8 in-in in 8.337 Saltbr-in 3.547 HRD-in -76.55, -51.58 69.18, 8.78 in-in-in SNCiii in-in ActLoopNT-in 2.995 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.78, 99.03 APE9-dihe-in -104.94, 133.88 APE8-dihe-in -73.17, 77.69 APE8-rot-na 29.01 APE67-dihe-in -66.28, -12.67 -56.63, -36.73 APE12-dist-na 13.315 APE11-dist-na 9.564 APE10-dist-na 10.422 APE9-dist-in 6.871 None None None XRAY 2.37 0.241 0.285 A 273 260 11 0 0 0 [[370, 628]] 1.0 4f4p Homo sapiens TYR_SYK_HUMAN TYR 4.3e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4DFNA P43405 363 635 635.0 0K1:60701 Type1 Active DFGin 6.49 14.454 BLAminus -130.15, -170.0 61.62, 83.88 -107.34, 23.58 294.6, 91.76 -72.41, -22.45 in-in in 8.746 Saltbr-in 3.183 HRD-in -85.27, -46.79 70.7, 5.96 in-in-in SNCiii in-in ActLoopNT-in 3.006 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.4, 98.4 APE9-dihe-in -102.46, 134.32 APE8-dihe-in -74.07, 82.6 APE8-rot-na 30.43 APE67-dihe-in -65.57, -16.86 -58.25, -34.59 APE12-dist-na 13.655 APE11-dist-na 10.708 APE10-dist-na 11.325 APE9-dist-in 7.301 None None None XRAY 2.48 0.222 0.273 A 274 268 5 0 0 0 [[370, 628]] 1.0 4dfn Homo sapiens TYR_SYK_HUMAN TYR 4.4e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4PV0A P43405 363 635 635.0 CG4:60701 Type1 Active DFGin 6.401 14.607 BLAminus -130.2, -175.25 67.21, 78.78 -101.45, 20.11 290.66, 99.39 -65.44, -27.35 in-in in 8.466 Saltbr-in 3.44 HRD-in -78.38, -54.31 73.62, 9.17 in-in-in SNCiii in-in ActLoopNT-in 2.835 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.94, 106.38 APE9-dihe-in -116.79, 139.9 APE8-dihe-in -79.38, 71.94 APE8-rot-na 33.78 APE67-dihe-in -68.26, -13.59 -53.62, -38.3 APE12-dist-na 13.161 APE11-dist-na 9.867 APE10-dist-na 10.488 APE9-dist-in 6.938 None None None XRAY 2.0 0.231 0.282 A 275 266 7 0 0 0 [[370, 628]] 1.0 4pv0 Homo sapiens TYR_SYK_HUMAN TYR 4.5e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 6HM6A P43405 364 632 635.0 GDK:701 Type1 Active DFGin 6.51 14.716 BLAminus -135.72, 178.12 60.9, 85.59 -101.68, 17.9 294.15, 88.35 -56.95, -33.53 in-in in 8.255 Saltbr-in 2.986 HRD-in -76.78, -53.52 71.64, 11.57 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -60.26, 138.11 APE9-dihe-in -138.15, 72.71 APE8-dihe-in -77.49, 77.46 APE8-rot-na 32.95 APE67-dihe-in -66.81, -17.94 -54.41, -33.99 APE12-dist-na 999.0 APE11-dist-na 9.239 APE10-dist-na 7.753 APE9-dist-in 7.668 None PTR525 PTR525 XRAY 2.1 0.217 0.29 A 276 261 8 0 0 2 [[370, 628]] 1.0 6hm6 Homo sapiens TYR_SYK_HUMAN TYR 4.5e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 3SRVA P43405 364 634 635.0 S19:1 Type1 Active DFGin 6.278 14.024 BLAminus -137.61, -172.24 65.42, 72.28 -96.27, 25.84 296.23, 89.02 -63.12, -26.69 in-in in 7.748 Saltbr-in 2.717 HRD-in -84.44, -49.93 72.25, 5.56 in-in-in SNCiii in-in ActLoopNT-in 2.973 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.48, 113.26 APE9-dihe-in -101.68, 153.86 APE8-dihe-in -78.64, 68.9 APE8-rot-na 34.87 APE67-dihe-in -67.25, -14.96 -56.26, -32.84 APE12-dist-na 12.931 APE11-dist-na 10.491 APE10-dist-na 11.935 APE9-dist-in 7.216 None PTR525 PTR525 XRAY 1.95 0.188 0.241 A 277 263 8 0 0 0 [[370, 628]] 1.0 3srv Homo sapiens TYR_SYK_HUMAN TYR 4.6e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 3SRVB P43405 364 632 635.0 S19:2 Type1 Active DFGin 6.283 14.236 BLAminus -130.89, -171.96 62.47, 72.82 -96.45, 25.83 293.72, 91.52 -65.61, -26.16 in-in in 7.663 Saltbr-in 2.967 HRD-in -72.4, -57.08 74.0, 8.38 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -91.35, 90.32 APE9-dihe-in -97.42, 146.07 APE8-dihe-in -79.19, 69.07 APE8-rot-na 34.2 APE67-dihe-in -70.71, -15.69 -52.0, -32.14 APE12-dist-na 13.211 APE11-dist-na 10.261 APE10-dist-na 10.871 APE9-dist-in 6.984 None None None XRAY 1.95 0.188 0.241 B 277 263 6 0 0 0 [[370, 628]] 1.0 3srv Homo sapiens TYR_SYK_HUMAN TYR 4.6e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 5LMAA P43405 363 632 635.0 6ZG:701 Type1 Active DFGin 6.708 14.754 BLAminus -128.5, -174.48 63.43, 65.54 -91.18, 18.15 286.4, 81.6 -62.6, -20.77 in-in in 8.001 Saltbr-in 2.769 HRD-in -78.56, -50.71 72.45, 5.63 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -59.08, 136.12 APE9-dihe-in -133.37, 70.56 APE8-dihe-in -71.66, 73.32 APE8-rot-na 31.65 APE67-dihe-in -63.61, -19.89 -49.48, -39.64 APE12-dist-na 999.0 APE11-dist-na 9.212 APE10-dist-na 7.699 APE9-dist-in 7.622 None PTR525 PTR525 XRAY 1.43 0.157 0.183 A 277 268 2 0 0 2 [[370, 628]] 1.0 5lma Homo sapiens TYR_SYK_HUMAN TYR 4.6e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 5LMBA P43405 364 634 635.0 6ZF:701 Type1 Active DFGin 6.448 14.283 BLAminus -131.02, -173.87 62.28, 69.39 -93.16, 19.0 290.08, 82.25 -59.68, -28.46 in-in in 7.696 Saltbr-in 2.454 HRD-in -78.06, -53.9 76.38, 4.89 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.66, 104.96 APE9-dihe-in -108.73, 152.4 APE8-dihe-in -79.7, 70.25 APE8-rot-na 31.84 APE67-dihe-in -69.34, -16.13 -51.43, -34.69 APE12-dist-na 13.073 APE11-dist-na 10.546 APE10-dist-na 11.448 APE9-dist-in 6.959 None PTR525 PTR525 XRAY 1.95 0.178 0.228 A 277 265 6 0 0 0 [[370, 628]] 1.0 5lmb Homo sapiens TYR_SYK_HUMAN TYR 4.6e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 6VOVB P43405 364 633 635.0 R6D:701 Type1 Active DFGin 6.674 14.628 BLAminus -133.89, -172.81 60.07, 70.15 -88.26, 20.03 288.32, 89.62 -58.86, -27.32 in-in in 8.08 Saltbr-in 2.622 HRD-in -78.67, -51.68 71.89, 6.23 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.76, 97.82 APE9-dihe-in -115.45, 146.07 APE8-dihe-in -78.23, 69.53 APE8-rot-na 28.65 APE67-dihe-in -63.96, -14.94 -44.81, -41.99 APE12-dist-na 13.646 APE11-dist-na 10.448 APE10-dist-na 11.033 APE9-dist-in 6.814 None None None XRAY 1.95 0.22 0.268 B 281 264 6 0 0 0 [[370, 628]] 1.0 6vov Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4YJOA P43405 363 632 635.0 4DF:701 Type1 Active DFGin 7.151 15.404 BLAminus -136.57, 178.57 59.58, 80.7 -95.16, 22.65 286.36, 75.19 -55.96, -31.16 in-in in 8.32 Saltbr-in 3.044 HRD-in -80.48, -52.4 72.29, 6.84 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.5, 127.44 APE9-dihe-in -144.08, 83.31 APE8-dihe-in -75.74, 70.97 APE8-rot-na 33.07 APE67-dihe-in -63.43, -16.56 -52.99, -37.5 APE12-dist-na 999.0 APE11-dist-na 10.63 APE10-dist-na 7.9 APE9-dist-in 7.507 None None None XRAY 1.6 0.186 0.23 A 281 267 3 0 0 3 [[370, 628]] 1.0 4yjo Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4YJPA P43405 364 632 635.0 4DL:701 Type1 Active DFGin 6.981 15.824 BLAminus -136.12, -172.87 58.52, 69.5 -93.88, 23.3 283.25, 78.78 -63.0, -28.48 in-in in 8.499 Saltbr-in 2.787 HRD-in -81.51, -48.52 67.75, 7.04 in-in-in SNCiii in-in ActLoopNT-in 2.945 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -52.7, 125.7 APE9-dihe-in -135.05, 78.45 APE8-dihe-in -76.25, 75.65 APE8-rot-na 35.36 APE67-dihe-in -66.34, -13.74 -58.49, -30.71 APE12-dist-na 999.0 APE11-dist-na 9.452 APE10-dist-na 7.369 APE9-dist-in 7.257 None None None XRAY 1.83 0.196 0.258 A 281 263 6 0 0 3 [[370, 628]] 1.0 4yjp Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4YJSA P43405 364 632 635.0 4DN:701 Type1 Active DFGin 6.811 15.74 BLAminus -130.65, -173.59 54.32, 75.2 -95.58, 22.43 287.83, 71.53 -54.84, -38.21 in-in in 8.514 Saltbr-in 3.084 HRD-in -80.45, -49.01 70.65, 8.19 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -50.21, 136.65 APE9-dihe-in -143.79, 77.69 APE8-dihe-in -76.44, 79.91 APE8-rot-na 34.0 APE67-dihe-in -64.44, -15.73 -58.23, -33.75 APE12-dist-na 13.07 APE11-dist-na 9.224 APE10-dist-na 7.474 APE9-dist-in 7.068 None None None XRAY 2.22 0.172 0.226 A 281 257 12 0 0 0 [[370, 628]] 1.0 4yjs Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 8RRQA P43405 363 632 635.0 A1H2W:701 Type1 Active DFGin 6.215 14.411 BLAminus -133.38, -167.55 71.76, 65.57 -94.48, 19.17 287.36, 93.75 -65.47, -22.18 in-in in 8.082 Saltbr-in 2.803 HRD-in -81.18, -51.78 70.8, 9.1 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.09, 108.93 APE9-dihe-in -135.72, 149.25 APE8-dihe-in -81.85, 69.97 APE8-rot-na 37.74 APE67-dihe-in -65.72, -15.06 -52.32, -34.71 APE12-dist-na 999.0 APE11-dist-na 10.224 APE10-dist-na 10.574 APE9-dist-in 6.743 None PTR525,PTR526 PTR525,PTR526 XRAY 1.6 0.178 0.211 A 282 268 2 0 0 2 [[370, 628]] 1.0 8rrq Homo sapiens TYR_SYK_HUMAN TYR 4.9e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 5TT7A P43405 358 635 635.0 7KF:60901 Type1 Active DFGin 6.311 14.341 BLAminus -130.62, -177.29 62.11, 72.82 -94.96, 21.67 289.95, 80.8 -60.6, -26.94 in-in in 7.709 Saltbr-in 2.84 HRD-in -77.7, -52.28 69.96, 13.2 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.65, 88.09 APE9-dihe-in -107.14, 140.48 APE8-dihe-in -78.3, 78.38 APE8-rot-na 32.04 APE67-dihe-in -64.56, -15.37 -56.64, -35.35 APE12-dist-na 13.888 APE11-dist-na 10.557 APE10-dist-na 10.342 APE9-dist-in 6.849 None None None XRAY 1.77 0.208 0.234 A 289 270 8 0 0 0 [[370, 628]] 1.0 5tt7 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 8XQ0A P43405 364 634 635.0 A1LV4:701 Type1 Active DFGin 6.154 14.743 BLAminus -131.25, -165.27 59.08, 66.28 -91.94, 24.84 295.79, 89.46 -66.54, -26.0 in-in in 8.841 Saltbr-in 2.39 HRD-in -77.49, -50.4 67.59, 11.98 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.4, 148.65 APE9-dihe-in -142.22, 83.4 APE8-dihe-in -79.88, 80.85 APE8-rot-na 30.05 APE67-dihe-in -71.39, -10.32 -63.91, -29.36 APE12-dist-na 999.0 APE11-dist-na 8.661 APE10-dist-na 7.465 APE9-dist-in 7.084 None None None XRAY 1.95 0.222 0.265 A 290 264 7 0 0 4 [[370, 628]] 1.0 8xq0 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 8XQ0C P43405 364 633 635.0 A1LV4:701 Type1 Active DFGin 6.064 14.771 BLAminus -131.08, -166.05 60.61, 65.77 -92.17, 22.95 297.06, 91.43 -65.35, -22.59 in-in in 8.197 Saltbr-in 2.474 HRD-in -81.66, -50.49 70.19, 9.23 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.0, 152.43 APE9-dihe-in -139.04, 83.13 APE8-dihe-in -80.21, 76.04 APE8-rot-na 29.28 APE67-dihe-in -67.25, -12.04 -57.38, -34.01 APE12-dist-na 999.0 APE11-dist-na 8.547 APE10-dist-na 7.75 APE9-dist-in 7.186 None None None XRAY 1.95 0.222 0.265 C 290 263 7 0 0 3 [[370, 628]] 1.0 8xq0 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 1XBCA P43405 363 635 635.0 STU:60001 Type1 Active DFGin 6.699 14.236 BLAminus -133.2, -171.25 54.9, 81.04 -97.63, 25.87 287.7, 80.31 -62.67, -30.77 in-in in 8.107 Saltbr-in 2.681 HRD-in -73.91, -54.08 72.64, 5.62 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.93, 102.31 APE9-dihe-in -115.14, 122.86 APE8-dihe-in -77.21, 74.28 APE8-rot-na 27.13 APE67-dihe-in -62.04, -14.77 -51.56, -42.64 APE12-dist-na 10.226 APE11-dist-na 10.661 APE10-dist-na 9.591 APE9-dist-in 6.83 None None None XRAY 2.0 0.246 0.294 A 291 267 6 0 0 0 [[370, 628]] 1.0 1xbc Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 3FQHA P43405 363 634 635.0 057:1 Type1 Active DFGin 6.389 14.293 BLAminus -136.21, -174.07 56.01, 83.39 -99.37, 22.02 289.52, 83.78 -53.8, -32.62 in-in in 7.989 Saltbr-in 2.983 HRD-in -76.47, -53.05 70.67, 6.23 in-in-in SNCiii in-in ActLoopNT-in 2.771 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.93, 113.08 APE9-dihe-in -110.56, 145.62 APE8-dihe-in -76.43, 69.28 APE8-rot-na 29.47 APE67-dihe-in -67.72, -12.14 -50.67, -39.65 APE12-dist-na 12.19 APE11-dist-na 10.46 APE10-dist-na 11.27 APE9-dist-in 6.993 None None None XRAY 2.26 0.216 0.259 A 291 262 10 0 0 0 [[370, 628]] 1.0 3fqh Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4GFGA P43405 363 635 635.0 0XF:60701 Type1 Active DFGin 6.382 14.706 BLAminus -133.41, -165.6 61.44, 68.78 -94.44, 29.51 290.84, 74.86 -64.09, -30.1 in-in in 8.551 Saltbr-in 3.497 HRD-in -86.12, -47.8 68.36, 5.25 in-in-in SNCiii in-in ActLoopNT-in 2.866 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -53.12, 138.6 APE9-dihe-in -110.15, 137.21 APE8-dihe-in -65.63, 68.92 APE8-rot-na 25.72 APE67-dihe-in -68.08, -17.47 -52.98, -35.53 APE12-dist-na 9.582 APE11-dist-na 10.629 APE10-dist-na 11.706 APE9-dist-in 7.231 None None None XRAY 2.35 0.221 0.246 A 291 273 0 0 0 0 [[370, 628]] 1.0 4gfg Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 5TIUA P43405 363 635 635.0 7CU:60701 Type1 Active DFGin 6.578 14.366 BLAminus -131.38, -173.31 61.91, 73.7 -95.93, 19.79 288.63, 86.78 -61.17, -26.75 in-in in 7.801 Saltbr-in 2.735 HRD-in -74.96, -48.82 70.27, 6.32 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.61, 84.89 APE9-dihe-in -101.52, 144.24 APE8-dihe-in -80.61, 68.84 APE8-rot-na 28.9 APE67-dihe-in -65.13, -16.04 -45.65, -40.25 APE12-dist-na 13.962 APE11-dist-na 10.844 APE10-dist-na 10.689 APE9-dist-in 7.1 None None None XRAY 1.49 0.186 0.203 A 291 262 11 0 0 0 [[370, 628]] 1.0 5tiu Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 5Y5TA P43405 363 635 635.0 8OR:701 Type1 Active DFGin 6.63 14.716 BLAminus -124.89, -179.45 65.71, 71.78 -93.94, 17.9 289.28, 88.8 -59.66, -30.83 in-in in 8.045 Saltbr-in 2.706 HRD-in -76.54, -52.99 73.97, 1.93 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -91.38, 59.43 APE9-dihe-in -101.74, 134.18 APE8-dihe-in -79.02, 75.85 APE8-rot-na 32.57 APE67-dihe-in -64.44, -15.76 -52.79, -38.69 APE12-dist-na 8.812 APE11-dist-na 11.931 APE10-dist-na 9.712 APE9-dist-in 6.991 None None None XRAY 1.8 0.196 0.234 A 293 263 10 0 0 0 [[370, 628]] 1.0 5y5t Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 5Y5UA P43405 364 634 635.0 8OU:701 Type1 Active DFGin 6.434 14.099 BLAminus -136.65, 173.94 66.9, 89.62 -105.43, 28.84 296.27, 90.39 -60.97, -30.93 in-in in 7.994 Saltbr-in 2.585 HRD-in -70.93, -52.74 73.81, 2.31 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.85, 121.36 APE9-dihe-in -125.49, 151.88 APE8-dihe-in -80.17, 69.97 APE8-rot-na 36.19 APE67-dihe-in -65.59, -17.51 -56.34, -35.15 APE12-dist-na 13.325 APE11-dist-na 10.867 APE10-dist-na 11.802 APE9-dist-in 7.226 None None None XRAY 2.14 0.239 0.26 A 293 266 5 0 0 0 [[370, 628]] 1.0 5y5u Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4WNMA P43405 347 635 635.0 3RT:60701 Type1 Active DFGin 6.269 14.204 BLAminus -122.7, 177.9 75.28, 74.2 -103.7, 21.48 302.37, 85.65 -56.81, -27.59 in-in in 8.279 Saltbr-in 2.749 HRD-in -73.5, -57.83 70.01, 16.8 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -49.99, 114.81 APE9-dihe-in -116.39, 136.86 APE8-dihe-in -71.67, 69.27 APE8-rot-na 29.91 APE67-dihe-in -63.86, -22.22 -60.87, -29.91 APE12-dist-na 12.409 APE11-dist-na 9.717 APE10-dist-na 10.738 APE9-dist-in 7.121 None None None XRAY 2.5 0.207 0.26 A 299 272 4 0 0 0 [[370, 628]] 1.0 4wnm Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 5C26A P43405 363 635 635.0 50H:60701 Type1 Active DFGin 6.407 14.905 BLAminus -133.47, -175.05 59.93, 80.73 -95.24, 23.48 291.98, 89.4 -57.38, -35.1 in-in in 8.232 Saltbr-in 2.756 HRD-in -77.18, -53.12 70.55, 7.56 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.23, 98.53 APE9-dihe-in -110.63, 147.85 APE8-dihe-in -78.58, 69.25 APE8-rot-na 30.18 APE67-dihe-in -65.45, -18.57 -48.55, -37.73 APE12-dist-na 13.311 APE11-dist-na 10.573 APE10-dist-na 10.592 APE9-dist-in 6.84 None PTR525,PTR526 PTR525,PTR526 XRAY 1.95 0.186 0.215 A 299 273 0 0 0 0 [[370, 628]] 1.0 5c26 Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 5C27A P43405 363 635 635.0 50J:60701 Type1 Active DFGin 6.359 14.612 BLAminus -130.06, -175.69 60.48, 84.21 -100.61, 25.88 296.18, 90.13 -67.7, -23.97 in-in in 8.325 Saltbr-in 2.79 HRD-in -75.03, -53.41 71.91, 4.7 in-in-in SNCiii in-in ActLoopNT-in 3.001 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.32, 89.13 APE9-dihe-in -103.36, 145.0 APE8-dihe-in -82.82, 67.41 APE8-rot-na 29.25 APE67-dihe-in -67.99, -14.11 -44.6, -40.88 APE12-dist-na 13.373 APE11-dist-na 10.038 APE10-dist-na 10.082 APE9-dist-in 6.751 None PTR525,PTR526 PTR525,PTR526 XRAY 2.15 0.179 0.225 A 299 273 0 0 0 0 [[370, 628]] 1.0 5c27 Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 6ZC0A P43405 363 635 635.0 QDZ:60701 Type1 Active DFGin 6.439 14.256 BLAminus -134.4, -168.89 64.15, 77.73 -98.13, 17.43 287.82, 84.9 -56.42, -33.19 in-in in 7.805 Saltbr-in 3.302 HRD-in -74.71, -54.58 68.95, 18.65 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.33, 89.82 APE9-dihe-in -113.19, 137.33 APE8-dihe-in -88.05, 72.58 APE8-rot-na 31.66 APE67-dihe-in -60.74, -19.2 -42.14, -42.2 APE12-dist-na 13.59 APE11-dist-na 10.088 APE10-dist-na 9.285 APE9-dist-in 6.833 None None None XRAY 1.97 0.194 0.229 A 299 264 9 0 0 0 [[370, 628]] 1.0 6zc0 Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 6ZCPA P43405 363 635 635.0 QFK:60701 Type1 Active DFGin 6.434 14.114 BLAminus -125.39, -166.55 56.04, 77.4 -99.95, 22.28 287.9, 88.75 -70.24, -19.9 in-in in 8.09 Saltbr-in 3.23 HRD-in -73.61, -47.62 64.51, 7.94 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.33, 97.29 APE9-dihe-in -119.56, 130.58 APE8-dihe-in -81.48, 76.65 APE8-rot-na 28.01 APE67-dihe-in -69.79, -11.02 -50.04, -33.72 APE12-dist-na 13.983 APE11-dist-na 11.018 APE10-dist-na 10.323 APE9-dist-in 7.258 None None None XRAY 2.2 0.213 0.234 A 299 264 9 0 0 0 [[370, 628]] 1.0 6zcp Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4RX7A P43405 363 635 635.0 3YV:60703 Type1 Active DFGin 6.368 14.51 BLAminus -135.93, -162.06 57.15, 54.11 -83.47, 19.55 290.31, 87.83 -58.61, -26.4 in-in in 8.151 Saltbr-in 2.906 HRD-in -74.07, -52.97 72.74, 4.77 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.3, 124.77 APE9-dihe-in -107.76, 142.43 APE8-dihe-in -82.91, 72.86 APE8-rot-na 31.05 APE67-dihe-in -64.64, -19.89 -48.22, -37.19 APE12-dist-na 12.646 APE11-dist-na 10.977 APE10-dist-na 11.221 APE9-dist-in 7.134 None None None XRAY 1.8 0.182 0.203 A 289 270 3 0 0 0 [[370, 628]] 1.0 4rx7 Homo sapiens TYR_SYK_HUMAN TYR 3.9e-90 307.6 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4RX8A P43405 364 635 635.0 3YX:60703 Type1 Active DFGin 6.375 14.344 BLAminus -127.63, -170.0 62.54, 75.55 -100.59, 22.48 287.33, 90.81 -63.45, -25.44 in-in in 8.034 Saltbr-in 2.841 HRD-in -76.4, -50.39 68.53, 9.44 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.6, 95.02 APE9-dihe-in -111.13, 149.03 APE8-dihe-in -81.54, 69.96 APE8-rot-na 29.76 APE67-dihe-in -66.91, -14.89 -51.35, -37.09 APE12-dist-na 999.0 APE11-dist-na 10.715 APE10-dist-na 10.621 APE9-dist-in 6.982 None None None XRAY 1.59 0.175 0.207 A 289 266 6 0 0 1 [[370, 628]] 1.0 4rx8 Homo sapiens TYR_SYK_HUMAN TYR 3.9e-90 307.6 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 5CXHA P43405 363 635 635.0 55M:60701 Type1 Active DFGin 6.44 14.323 BLAminus -133.42, -179.45 56.74, 83.68 -97.45, 24.47 292.79, 86.46 -58.74, -36.41 in-in in 7.662 Saltbr-in 2.858 HRD-in -70.81, -53.82 70.99, 7.51 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.96, 96.35 APE9-dihe-in -104.24, 139.79 APE8-dihe-in -78.53, 71.61 APE8-rot-na 29.83 APE67-dihe-in -66.63, -19.71 -51.23, -33.62 APE12-dist-na 13.123 APE11-dist-na 10.837 APE10-dist-na 10.88 APE9-dist-in 7.052 K467T None None XRAY 1.9 0.176 0.205 A 289 273 0 0 0 0 [[370, 628]] 1.0 5cxh Homo sapiens TYR_SYK_HUMAN TYR 3.9e-90 307.6 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4RX9A P43405 363 635 635.0 3YT:60702 Type1 Active DFGin 6.536 14.498 BLAminus -131.55, -166.02 53.8, 76.49 -95.21, 18.16 288.88, 90.96 -57.69, -29.73 in-in in 8.168 Saltbr-in 3.125 HRD-in -77.32, -52.67 70.66, 10.77 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.14, 87.16 APE9-dihe-in -107.75, 147.74 APE8-dihe-in -79.62, 70.69 APE8-rot-na 28.2 APE67-dihe-in -66.03, -15.15 -48.72, -38.82 APE12-dist-na 999.0 APE11-dist-na 11.076 APE10-dist-na 10.761 APE9-dist-in 6.997 None None None XRAY 1.75 0.175 0.197 A 290 264 9 0 0 1 [[370, 628]] 1.0 4rx9 Homo sapiens TYR_SYK_HUMAN TYR 4e-90 307.6 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 5CY3A P43405 360 635 635.0 55Y:60701 Type1 Active DFGin 6.295 14.611 BLAminus -132.49, 178.84 54.8, 80.29 -90.47, 18.93 290.07, 88.96 -55.0, -39.22 in-in in 8.197 Saltbr-in 2.763 HRD-in -80.6, -49.34 69.47, 8.41 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.58, 101.42 APE9-dihe-in -106.21, 146.28 APE8-dihe-in -84.7, 72.08 APE8-rot-na 31.82 APE67-dihe-in -66.44, -12.67 -53.8, -35.38 APE12-dist-na 13.383 APE11-dist-na 10.361 APE10-dist-na 10.987 APE9-dist-in 7.136 K467T None None XRAY 1.76 0.171 0.195 A 291 274 2 0 0 0 [[370, 628]] 1.0 5cy3 Homo sapiens TYR_SYK_HUMAN TYR 4e-90 307.6 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4DFLA P43405 363 635 635.0 0K0:60701 Type1 Inactive DFGin 6.483 14.571 BLAminus -118.07, -176.51 65.46, 77.03 -97.43, 24.23 290.23, 82.73 -67.62, -27.84 in-in in 8.444 Saltbr-in 3.134 HRD-in -79.8, -55.87 75.57, 9.89 in-in-out SNCiio in-out ActLoopNT-in 2.948 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 50.15, 72.02 APE9-dihe-in -112.79, 133.67 APE8-dihe-in -76.3, 73.19 APE8-rot-na 32.11 APE67-dihe-in -65.46, -14.43 -51.92, -39.05 APE12-dist-na 13.047 APE11-dist-na 10.349 APE10-dist-na 9.761 APE9-dist-in 6.799 None None None XRAY 1.98 0.199 0.243 A 274 262 11 0 0 0 [[370, 628]] 1.0 4dfl Homo sapiens TYR_SYK_HUMAN TYR 4.4e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4YJQA P43405 364 633 635.0 4DK:701 Type1 Inactive DFGin 6.736 15.804 BLAminus -134.82, -177.19 61.29, 79.22 -100.06, 24.96 286.87, 77.55 -63.45, -29.36 in-out in 8.758 Saltbr-out 4.895 HRD-in -81.67, -53.67 71.29, 13.22 out-in-in SNCoii in-in ActLoopNT-in 2.91 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.36, 108.33 APE9-dihe-in -126.44, 157.88 APE8-dihe-in -80.8, 70.11 APE8-rot-na 32.3 APE67-dihe-in -67.03, -13.75 -58.2, -31.61 APE12-dist-na 13.861 APE11-dist-na 10.931 APE10-dist-na 11.308 APE9-dist-in 6.894 None PTR525,PTR526 PTR525,PTR526 XRAY 1.34 0.162 0.183 A 281 266 4 0 0 0 [[370, 628]] 1.0 4yjq Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4YJRA P43405 364 633 635.0 4DJ:701 Type1 Inactive DFGin 6.624 15.887 BLAminus -132.72, -177.45 60.79, 79.89 -101.88, 24.11 286.03, 77.25 -63.73, -27.17 in-out in 8.78 Saltbr-out 4.806 HRD-in -81.52, -53.74 71.69, 12.94 out-in-in SNCoii in-in ActLoopNT-in 2.928 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.41, 106.79 APE9-dihe-in -125.28, 158.73 APE8-dihe-in -81.3, 69.56 APE8-rot-na 32.68 APE67-dihe-in -66.27, -14.56 -57.04, -32.84 APE12-dist-na 13.842 APE11-dist-na 10.887 APE10-dist-na 11.238 APE9-dist-in 6.86 None PTR525,PTR526 PTR525,PTR526 XRAY 1.32 0.157 0.18 A 281 265 5 0 0 0 [[370, 628]] 1.0 4yjr Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4YJTA P43405 364 633 635.0 4DQ:702 Type1 Inactive DFGin 7.064 15.582 BLAminus -131.45, -174.52 58.96, 73.99 -96.84, 26.0 284.85, 76.07 -63.21, -26.17 in-out in 8.667 Saltbr-out 3.811 HRD-in -83.12, -51.93 70.87, 9.98 out-in-in SNCoii in-in ActLoopNT-in 2.893 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.18, 103.7 APE9-dihe-in -124.22, 158.86 APE8-dihe-in -80.04, 67.83 APE8-rot-na 30.81 APE67-dihe-in -66.36, -14.14 -52.34, -34.06 APE12-dist-na 14.101 APE11-dist-na 10.888 APE10-dist-na 11.114 APE9-dist-in 6.862 None PTR525,PTR526 PTR525,PTR526 XRAY 1.52 0.176 0.208 A 281 270 0 0 0 0 [[370, 628]] 1.0 4yjt Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4YJUA P43405 364 633 635.0 4DO:701 Type1 Inactive DFGin 7.107 15.38 BLAminus -134.61, -176.9 55.67, 76.17 -94.03, 20.15 284.44, 74.82 -57.56, -25.54 in-out in 8.574 Saltbr-out 3.757 HRD-in -78.76, -50.17 71.23, 5.94 out-in-in SNCoii in-in ActLoopNT-in 2.861 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.06, 116.81 APE9-dihe-in -121.69, 162.72 APE8-dihe-in -76.87, 70.03 APE8-rot-na 31.7 APE67-dihe-in -64.01, -12.06 -45.6, -41.35 APE12-dist-na 999.0 APE11-dist-na 11.421 APE10-dist-na 11.903 APE9-dist-in 6.828 None PTR525,PTR526 PTR525,PTR526 XRAY 1.67 0.168 0.201 A 281 267 3 0 0 3 [[370, 628]] 1.0 4yju Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4YJVA P43405 364 633 635.0 4DT:701 Type1 Inactive DFGin 7.058 15.539 BLAminus -132.12, -177.62 58.9, 78.21 -97.23, 24.66 284.8, 77.05 -61.21, -27.61 in-out in 8.601 Saltbr-out 4.961 HRD-in -80.51, -52.41 71.92, 9.69 out-in-in SNCoii in-in ActLoopNT-in 2.903 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.0, 101.75 APE9-dihe-in -120.35, 161.01 APE8-dihe-in -81.1, 68.03 APE8-rot-na 32.46 APE67-dihe-in -66.69, -14.4 -54.32, -33.4 APE12-dist-na 13.919 APE11-dist-na 10.8 APE10-dist-na 11.156 APE9-dist-in 6.838 None PTR525,PTR526 PTR525,PTR526 XRAY 1.652 0.177 0.222 A 281 265 5 0 0 0 [[370, 628]] 1.0 4yjv Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4RSSA P43405 364 634 635.0 4MG:701 Type1 Inactive DFGin 6.362 14.374 BLAminus -125.51, 178.89 70.7, 70.71 -93.1, 15.53 292.82, 95.43 -58.12, -23.53 in-in in 7.98 Saltbr-in 2.647 HRD-in -80.43, -50.69 72.79, 4.21 in-in-out SNCiio in-out ActLoopNT-in 2.983 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -83.33, -31.98 APE9-dihe-out -62.19, -39.48 APE8-dihe-out -88.75, -5.81 APE8-rot-na 36.86 APE67-dihe-in -61.38, -18.45 -51.57, -40.88 APE12-dist-na 11.195 APE11-dist-na 13.649 APE10-dist-na 16.633 APE9-dist-out 10.407 None None None XRAY 1.83 0.214 0.249 A 290 269 2 0 0 0 [[370, 628]] 1.0 4rss Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4XG3A P43405 363 634 635.0 X3G:701 Type1 Inactive DFGin 6.561 14.269 BLAminus -123.77, -176.77 60.27, 75.02 -93.24, 14.93 290.25, 93.45 -52.4, -30.37 in-out in 7.883 Saltbr-out 4.373 HRD-in -78.91, -49.84 68.75, 12.99 out-in-in SNCoii in-in ActLoopNT-in 2.812 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.51, 96.9 APE9-dihe-in -112.53, 139.55 APE8-dihe-in -74.31, 78.49 APE8-rot-na 32.23 APE67-dihe-in -68.63, -15.73 -57.45, -34.9 APE12-dist-na 14.073 APE11-dist-na 11.005 APE10-dist-na 10.913 APE9-dist-in 7.156 None None None XRAY 2.3 0.199 0.226 A 290 262 10 0 0 0 [[370, 628]] 1.0 4xg3 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4XG7A P43405 364 635 635.0 X7G:60701 Type1 Inactive DFGin 6.447 14.323 BLAminus -121.7, -179.92 65.73, 76.06 -96.8, 16.58 293.04, 92.3 -59.19, -26.5 in-in in 7.786 Saltbr-in 2.689 HRD-in -75.48, -50.53 70.33, 10.44 in-in-out SNCiio in-out ActLoopNT-in 2.919 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -77.68, -30.64 APE9-dihe-out -62.97, -34.6 APE8-dihe-out -91.68, -6.53 APE8-rot-na 34.14 APE67-dihe-in -64.14, -15.96 -52.05, -39.51 APE12-dist-na 11.128 APE11-dist-na 13.477 APE10-dist-na 16.568 APE9-dist-out 10.333 None None None XRAY 1.76 0.226 0.242 A 290 265 7 0 0 0 [[370, 628]] 1.0 4xg7 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4XG8A P43405 366 635 635.0 X8G:700 Type1 Inactive DFGin 6.391 14.632 BLAminus -120.1, -177.66 66.71, 68.41 -88.21, 14.67 295.9, 86.73 -47.78, -34.81 in-out in 8.259 Saltbr-out 5.005 HRD-in -67.74, -56.67 79.0, 1.4 out-in-none SNCoin in-none ActLoopNT-in 2.808 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 10.07 APE8-rot-na 35.22 APE67-dihe-in -73.7, -4.5 -52.82, -36.93 APE12-dist-na 11.636 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.249 0.275 A 290 258 12 0 0 3 [[370, 628]] 1.0 4xg8 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4I0TA P43405 363 635 635.0 1B6:60701 Type1 Inactive DFGin 6.448 14.275 BLAminus -133.28, -166.54 54.17, 83.04 -99.17, 23.72 289.92, 92.88 -54.78, -30.8 in-in in 8.482 Saltbr-in 2.757 HRD-in -78.62, -52.01 75.91, 3.75 in-in-out SNCiio in-out ActLoopNT-in 3.005 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.47 APE8-dihe-in -63.58, 54.66 APE8-rot-na 27.19 APE67-dihe-in -65.32, -17.31 -39.09, -36.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.562 None None None XRAY 1.7 0.236 0.268 A 291 262 11 0 0 5 [[370, 628]] 1.0 4i0t Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 3EMGA P43405 365 631 635.0 685:685 Type1 Inactive DFGin 6.424 14.435 BLAminus -130.99, -164.55 52.75, 65.2 -80.56, 24.97 299.65, 78.19 -64.0, -22.78 in-out in 8.148 Saltbr-out 3.969 HRD-in -79.71, -50.4 83.15, -12.3 out-in-none SNCoin in-none ActLoopNT-in 3.061 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -116.55 APE9-dihe-in -116.09, 161.75 APE8-dihe-in -79.75, 74.02 APE8-rot-na 34.39 APE67-dihe-in -47.92, -26.61 -60.2, -39.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.895 APE9-dist-in 7.289 None None None XRAY 2.6 0.2 0.222 A 291 255 12 0 0 4 [[370, 628]] 1.0 3emg Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4FL3A P43405 9 635 635.0 ANP:701 ATPlike Inactive DFGin 5.271 12.411 BLBplus -116.27, 169.06 58.02, 22.77 -60.26, 128.95 39.87, 90.8 70.36, 3.28 out-out out 13.347 Saltbr-out 12.957 HRD-in -71.66, -54.51 80.39, -19.8 out-out-none SNCoon out-none ActLoopNT-out 7.03 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 2.25 APE8-rot-na 29.04 APE67-dihe-in -63.72, -20.72 -59.66, -31.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y348F,Y352F None None XRAY 1.9 0.18 0.208 A 635 538 13 0 0 13 [[370, 628]] 1.0 4fl3 Homo sapiens TYR_SYK_HUMAN TYR 5.1e-89 304.2 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4FL2A P43405 9 635 635.0 ANP:702 ATPlike Inactive DFGin 5.428 12.328 BLBplus -115.2, 163.41 55.5, 31.26 -66.72, 128.2 35.56, 90.39 65.72, 13.6 out-out out 13.491 Saltbr-out 13.203 HRD-in -70.05, -49.77 75.03, -15.27 out-out-out SNCooo out-out ActLoopNT-out 7.194 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.16, 144.55 APE9-dihe-in -104.91, 94.8 APE8-dihe-out -50.62, -30.17 APE8-rot-na 333.32 APE67-dihe-in -61.99, -18.29 -62.08, -21.97 APE12-dist-na 15.556 APE11-dist-na 19.206 APE10-dist-na 15.736 APE9-dist-out 11.527 None None None XRAY 2.19 0.184 0.228 A 636 555 0 0 0 0 [[370, 628]] 1.0 4fl2 Homo sapiens TYR_SYK_HUMAN TYR 5.1e-89 304.2 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 3TUCA P43405 358 633 635.0 FPW:999 Type1.5_Front Inactive DFGin 6.556 15.019 BLBplus -114.33, 165.27 53.65, 40.82 -73.1, 146.31 90.45, 83.64 -43.15, -55.01 out-out out 11.471 Saltbr-out 7.068 HRD-in -66.05, -58.66 86.11, -25.8 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.49 APE8-rot-na 24.54 APE67-dihe-in -67.39, -16.05 -47.1, -39.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.216 0.285 A 299 257 19 0 0 19 [[370, 628]] 1.0 3tuc Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 3TUBA P43405 362 633 635.0 FPU:999 Type2 Inactive DFGout 13.74 9.67 BBAminus -126.08, 171.13 -141.46, 68.74 -40.79, -49.16 289.47, 103.31 -92.66, 19.79 in-out in 8.316 Saltbr-out 3.667 HRD-in -62.48, -58.18 81.87, -14.31 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 55.79 APE8-rot-na 29.91 APE67-dihe-in -67.44, -14.12 -48.38, -36.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.23 0.182 0.232 A 293 253 19 0 0 19 [[370, 628]] 1.0 3tub Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 3TUDA P43405 363 635 635.0 FPX:60001 Type2 Inactive DFGout 15.309 10.866 None -123.06, 178.93 -154.97, 96.56 -80.58, 999.0 302.91, 174.18 999.0, 999.0 in-in in 8.75 Saltbr-in 2.756 HRD-in -65.87, -59.08 79.62, -13.62 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -60.05, 129.63 APE9-dihe-in -111.2, 153.71 APE8-dihe-in -83.04, 71.46 APE8-rot-na 31.48 APE67-dihe-in -66.5, -12.19 -53.72, -36.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.652 None None None XRAY 2.33 0.198 0.263 A 299 255 18 0 0 18 [[370, 628]] 1.0 3tud Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4XG2A P43405 364 635 635.0 No_ligand No_ligand None DFGin 6.56 14.743 BLAminus -130.24, -178.99 62.72, 77.6 -96.14, 15.75 290.58, 78.21 -62.22, -24.62 in-in in 8.189 Saltbr-in 2.79 HRD-in -76.73, -52.8 72.67, 7.33 in-in-none SNCiin in-none ActLoopNT-in 2.857 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 129.75 APE9-dihe-in -121.46, 135.12 APE8-dihe-in -76.71, 74.12 APE8-rot-na 35.22 APE67-dihe-in -65.91, -17.02 -54.02, -32.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.903 APE9-dist-in 7.056 None None None XRAY 2.21 0.204 0.227 A 290 258 14 0 0 4 [[370, 628]] 1.0 4xg2 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 6HM7A P43405 363 633 635.0 GDH:701 Type1 None DFGin 6.553 14.527 BLAminus -123.85, -179.77 64.31, 73.15 -92.84, 18.31 290.79, 83.99 -60.41, -28.58 in-in in 8.033 Saltbr-in 2.928 HRD-in -76.88, -50.91 71.45, 2.92 in-in-none SNCiin in-none ActLoopNT-in 2.904 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 157.3 APE8-dihe-in -78.81, 69.42 APE8-rot-na 32.62 APE67-dihe-in -63.42, -18.8 -55.15, -34.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.568 None PTR525 PTR525 XRAY 1.64 0.174 0.21 A 276 268 3 0 0 3 [[370, 628]] 1.0 6hm7 Homo sapiens TYR_SYK_HUMAN TYR 4.5e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 5LMBB P43405 364 630 635.0 6ZF:701 Type1 None DFGin 6.542 14.207 BLAminus -133.05, -174.7 62.98, 72.21 -97.02, 21.38 290.54, 88.36 -62.52, -32.46 in-in in 7.737 Saltbr-in 2.556 HRD-in -77.26, -52.74 74.6, 8.57 in-in-none SNCiin in-none ActLoopNT-in 2.872 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.43 APE8-dihe-in -80.7, 73.18 APE8-rot-na 30.16 APE67-dihe-in -64.42, -18.25 -49.18, -37.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.948 None PTR525 PTR525 XRAY 1.95 0.178 0.228 B 277 262 5 0 0 5 [[370, 628]] 1.0 5lmb Homo sapiens TYR_SYK_HUMAN TYR 4.6e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 8X5KA P43405 363 632 635.0 3YT:701 Type1 None DFGin 6.382 14.656 BLAminus -132.21, -172.26 63.3, 68.78 -95.24, 19.38 292.18, 89.98 -56.7, -30.78 in-in in 7.894 Saltbr-in 2.95 HRD-in -71.77, -56.19 75.58, 0.61 in-in-none SNCiin in-none ActLoopNT-in 2.948 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.95 APE8-rot-na 32.78 APE67-dihe-in -63.64, -18.99 -57.25, -32.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.192 0.244 A 280 264 6 0 0 5 [[370, 628]] 1.0 8x5k Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 6VOVA P43405 363 629 635.0 R6D:701 Type1 None DFGin 6.491 14.551 BLAminus -133.59, -172.02 59.62, 69.16 -89.35, 17.8 288.33, 91.38 -60.0, -27.27 in-in in 7.994 Saltbr-in 2.69 HRD-in -77.79, -51.77 71.65, 6.09 in-in-none SNCiin in-none ActLoopNT-in 2.99 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.03 APE8-dihe-in -78.95, 69.83 APE8-rot-na 28.75 APE67-dihe-in -65.35, -15.72 -44.66, -41.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.197 None None None XRAY 1.95 0.22 0.268 A 281 258 9 0 0 4 [[370, 628]] 1.0 6vov Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 8RRZA P43405 363 633 635.0 A1H2Y:701 Type1 None DFGin 6.461 14.682 BLAminus -127.74, -179.45 67.79, 70.28 -94.76, 22.67 287.65, 98.81 -62.91, -34.06 in-in in 7.964 Saltbr-in 2.897 HRD-in -78.47, -50.78 73.26, 5.22 in-in-none SNCiin in-none ActLoopNT-in 2.939 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.18 APE8-dihe-in -75.14, 72.0 APE8-rot-na 32.71 APE67-dihe-in -61.9, -17.04 -54.99, -37.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.332 None PTR525,PTR526 PTR525,PTR526 XRAY 1.75 0.182 0.214 A 282 262 9 0 0 4 [[370, 628]] 1.0 8rrz Homo sapiens TYR_SYK_HUMAN TYR 4.9e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 5TR6A P43405 362 635 635.0 7KG:60701 Type1 None DFGin 6.42 14.422 BLAminus -132.48, 179.72 59.87, 74.11 -95.94, 22.5 287.39, 87.93 -67.35, -26.8 in-none in 7.993 Saltbr-none 999.0 HRD-in -77.83, -50.78 68.92, 14.83 none-in-in SNCnii in-in ActLoopNT-in 2.921 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.28, 93.77 APE9-dihe-in -107.16, 142.31 APE8-dihe-in -78.63, 77.12 APE8-rot-na 32.22 APE67-dihe-in -65.12, -14.48 -58.58, -35.04 APE12-dist-na 13.682 APE11-dist-na 10.164 APE10-dist-na 10.507 APE9-dist-in 6.975 None None None XRAY 1.93 0.195 0.217 A 289 268 6 0 0 0 [[370, 628]] 1.0 5tr6 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4XG3B P43405 363 633 635.0 X3G:701 Type1 None DFGin 6.361 14.26 BLAminus -128.52, -176.24 59.83, 77.98 -95.46, 17.98 292.06, 88.72 -55.83, -35.07 in-in in 7.757 Saltbr-in 2.713 HRD-in -74.45, -44.97 66.32, 3.24 in-in-none SNCiin in-none ActLoopNT-in 3.038 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 60.87 APE9-dihe-in -106.83, 127.91 APE8-dihe-in -75.62, 80.4 APE8-rot-na 32.03 APE67-dihe-in -68.27, -18.81 -58.02, -33.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.758 APE9-dist-in 7.133 None None None XRAY 2.3 0.199 0.226 B 290 267 4 0 0 4 [[370, 628]] 1.0 4xg3 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4XG4A P43405 363 635 635.0 X4G:701 Type1 None DFGin 6.633 14.5 BLAminus -121.07, 179.74 64.97, 74.28 -96.12, 21.86 293.04, 85.88 -61.26, -26.24 in-in in 7.936 Saltbr-in 2.671 HRD-in -75.83, -50.72 70.19, 14.15 in-in-none SNCiin in-none ActLoopNT-in 2.933 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 92.08 APE9-dihe-in -117.97, 139.01 APE8-dihe-in -75.6, 78.94 APE8-rot-na 30.7 APE67-dihe-in -67.4, -20.31 -55.84, -33.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.903 APE9-dist-in 7.112 None None None XRAY 2.3 0.195 0.228 A 290 264 9 0 0 4 [[370, 628]] 1.0 4xg4 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4XG6A P43405 363 635 635.0 X6G:60701 Type1 None DFGin 6.254 14.314 BLAminus -118.6, -179.8 61.85, 86.51 -104.68, 19.31 297.54, 90.69 -53.97, -29.58 in-in in 7.848 Saltbr-in 2.675 HRD-in -72.81, -51.23 73.7, 7.07 in-in-none SNCiin in-none ActLoopNT-in 2.908 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -1.44 APE8-rot-na 30.73 APE67-dihe-in -63.62, -23.47 -57.96, -32.34 APE12-dist-na 11.58 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.192 0.23 A 290 270 3 0 0 3 [[370, 628]] 1.0 4xg6 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4XG8C P43405 364 629 635.0 X8G:700 Type1 None DFGin 6.369 14.266 BLAminus -112.98, -178.28 65.43, 72.58 -97.08, 19.7 293.26, 93.71 -69.16, -21.23 in-in in 8.045 Saltbr-in 2.925 HRD-in -74.14, -54.5 72.61, 6.51 in-in-none SNCiin in-none ActLoopNT-in 2.709 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 27.72 APE8-rot-na 24.07 APE67-dihe-in -75.25, -15.23 -58.44, -32.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.249 0.275 C 290 254 12 0 0 5 [[370, 628]] 1.0 4xg8 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4XG9A P43405 363 632 635.0 X9G:700 Type1 None DFGin 6.388 14.253 BLAminus -123.44, -179.44 57.72, 74.85 -93.27, 25.8 301.09, 93.35 -61.2, -36.75 in-in in 7.964 Saltbr-in 2.623 HRD-in -74.42, -57.7 72.94, 15.94 in-in-none SNCiin in-none ActLoopNT-in 2.787 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 14.65 APE8-rot-na 19.29 APE67-dihe-in -69.72, -24.67 -61.87, -28.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.91 0.21 0.241 A 290 259 11 0 0 6 [[370, 628]] 1.0 4xg9 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4XG9B P43405 363 634 635.0 X9G:700 Type1 None DFGin 6.347 14.216 BLAminus -128.68, -177.25 53.27, 77.68 -95.83, 18.82 297.69, 92.87 -61.29, -26.93 in-in in 7.968 Saltbr-in 2.503 HRD-in -72.55, -56.82 71.48, 16.81 in-in-none SNCiin in-none ActLoopNT-in 2.833 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 14.58 APE8-rot-na 27.68 APE67-dihe-in -67.7, -23.41 -54.17, -35.6 APE12-dist-na 11.89 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.91 0.21 0.241 B 290 265 7 0 0 3 [[370, 628]] 1.0 4xg9 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 5GHVA P43405 363 635 635.0 X5G:701 Type1 None DFGin 6.51 14.486 BLAminus -121.34, 177.94 62.19, 88.65 -109.69, 41.48 296.98, 84.28 -77.6, -32.83 in-in in 8.11 Saltbr-in 2.732 HRD-in -76.16, -59.71 78.21, 9.71 in-in-none SNCiin in-none ActLoopNT-in 2.964 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 59.75 APE9-dihe-in -134.2, 142.35 APE8-dihe-in -78.13, 86.38 APE8-rot-na 29.33 APE67-dihe-in -64.76, -25.26 -61.51, -32.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.668 APE9-dist-in 7.398 None None None XRAY 2.8 0.217 0.227 A 290 265 8 0 0 4 [[370, 628]] 1.0 5ghv Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 5GHVB P43405 363 635 635.0 X5G:701 Type1 None DFGin 6.495 14.39 BLAminus -125.29, 176.55 63.13, 89.9 -112.44, 39.0 296.07, 82.84 -75.29, -45.81 in-in in 8.074 Saltbr-in 2.715 HRD-in -75.16, -55.76 75.92, 10.79 in-in-none SNCiin in-none ActLoopNT-in 3.094 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 48.46 APE9-dihe-in -133.95, 133.36 APE8-dihe-in -79.51, 91.82 APE8-rot-na 28.71 APE67-dihe-in -66.71, -23.44 -67.07, -29.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.251 APE9-dist-in 7.569 None None None XRAY 2.8 0.217 0.227 B 290 265 8 0 0 4 [[370, 628]] 1.0 5ghv Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 8XQ0B P43405 364 634 635.0 A1LV4:701 Type1 None DFGin 6.294 14.269 BLAminus -121.56, -165.09 54.01, 77.14 -98.56, 23.24 296.48, 92.65 -61.88, -28.43 in-in in 8.418 Saltbr-in 2.649 HRD-in -77.64, -48.09 70.42, 13.58 in-in-none SNCiin in-none ActLoopNT-in 2.796 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 110.46 APE9-dihe-in -140.12, 100.43 APE8-dihe-in -73.17, 75.7 APE8-rot-na 30.62 APE67-dihe-in -68.44, -13.24 -66.75, -26.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.655 APE9-dist-in 6.875 None None None XRAY 1.95 0.222 0.265 B 290 253 18 0 0 4 [[370, 628]] 1.0 8xq0 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 8XQ0D P43405 364 635 635.0 A1LV4:701 Type1 None DFGin 6.314 14.39 BLAminus -120.19, -170.79 65.2, 70.98 -95.79, 24.62 295.16, 93.42 -63.39, -28.44 in-in in 8.488 Saltbr-in 2.701 HRD-in -76.01, -49.61 70.34, 8.1 in-in-none SNCiin in-none ActLoopNT-in 2.787 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 140.86 APE9-dihe-in -154.41, 100.57 APE8-dihe-in -72.25, 67.88 APE8-rot-na 28.73 APE67-dihe-in -63.58, -17.28 -53.94, -36.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.164 APE9-dist-in 6.963 None None None XRAY 1.95 0.222 0.265 D 290 258 14 0 0 4 [[370, 628]] 1.0 8xq0 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 8XQ1A P43405 364 634 635.0 A1LV6:901 Type1 None DFGin 6.301 14.482 BLAminus -124.74, -173.52 66.63, 71.35 -96.63, 19.35 289.84, 89.05 -66.02, -25.46 in-in in 8.266 Saltbr-in 2.817 HRD-in -80.15, -50.35 70.61, 8.83 in-in-none SNCiin in-none ActLoopNT-in 2.96 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 134.1 APE9-dihe-in -110.96, 150.88 APE8-dihe-in -81.12, 69.26 APE8-rot-na 30.82 APE67-dihe-in -65.34, -12.5 -60.05, -31.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.595 APE9-dist-in 7.086 None None None XRAY 1.5 0.188 0.209 A 290 263 8 0 0 3 [[370, 628]] 1.0 8xq1 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 8XQ1B P43405 364 634 635.0 A1LV6:901 Type1 None DFGin 6.306 14.438 BLAminus -122.4, -173.86 66.54, 73.25 -99.1, 21.97 289.94, 89.92 -65.7, -26.72 in-in in 8.205 Saltbr-in 2.828 HRD-in -76.67, -51.02 71.1, 10.17 in-in-none SNCiin in-none ActLoopNT-in 2.981 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 119.35 APE9-dihe-in -109.54, 149.84 APE8-dihe-in -80.64, 68.82 APE8-rot-na 32.7 APE67-dihe-in -66.82, -12.34 -64.74, -24.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.364 APE9-dist-in 7.112 None None None XRAY 1.5 0.188 0.209 B 290 263 8 0 0 3 [[370, 628]] 1.0 8xq1 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 8XQ2A P43405 363 634 635.0 A1LV7:802 Type1 None DFGin 6.366 14.425 BLAminus -126.78, -178.48 65.06, 70.63 -92.55, 21.67 293.19, 85.55 -66.06, -22.05 in-in in 8.341 Saltbr-in 2.829 HRD-in -77.37, -51.66 73.37, 4.48 in-in-none SNCiin in-none ActLoopNT-in 2.903 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 83.79 APE8-rot-na 27.63 APE67-dihe-in -66.2, -13.18 -59.95, -35.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.206 0.238 A 290 263 9 0 0 4 [[370, 628]] 1.0 8xq2 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 8XQ2B P43405 364 632 635.0 A1LV7:701 Type1 None DFGin 6.407 14.57 BLAminus -126.32, -176.03 64.56, 73.36 -94.65, 19.7 292.4, 83.49 -62.95, -22.08 in-in in 8.283 Saltbr-in 2.921 HRD-in -78.79, -49.2 70.93, 7.72 in-in-none SNCiin in-none ActLoopNT-in 2.952 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 81.5 APE9-dihe-in -124.35, 129.64 APE8-dihe-in -71.15, 79.1 APE8-rot-na 29.02 APE67-dihe-in -66.5, -10.69 -61.42, -32.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.75 APE9-dist-in 6.84 None None None XRAY 1.8 0.206 0.238 B 290 261 8 0 0 2 [[370, 628]] 1.0 8xq2 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 1XBBA P43405 363 635 635.0 STI:60001 Type1 None DFGin 6.664 14.623 BLAminus -128.05, 176.75 68.38, 79.08 -100.61, 19.15 290.6, 90.35 -58.48, -28.27 in-in in 8.236 Saltbr-in 3.032 HRD-in -76.13, -51.62 74.69, 4.56 in-in-none SNCiin in-none ActLoopNT-in 2.878 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 178.76 APE9-dihe-in -111.48, 137.0 APE8-dihe-in -74.08, 70.57 APE8-rot-na 29.87 APE67-dihe-in -65.65, -14.73 -52.2, -36.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.126 APE9-dist-in 7.2 None None None XRAY 1.57 0.191 0.221 A 291 264 9 0 0 4 [[370, 628]] 1.0 1xbb Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 3FQEA P43405 363 635 635.0 P5C:60001 Type1 None DFGin 6.241 14.552 BLAminus -134.09, -160.32 61.99, 71.61 -98.66, 22.24 289.6, 83.21 -60.61, -25.52 in-in in 8.249 Saltbr-in 3.362 HRD-in -87.09, -50.31 69.38, 7.86 in-in-none SNCiin in-none ActLoopNT-in 2.953 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 126.45 APE9-dihe-in -122.15, 142.06 APE8-dihe-in -70.06, 69.94 APE8-rot-na 27.41 APE67-dihe-in -70.93, -8.12 -53.23, -38.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.212 APE9-dist-in 7.072 None None None XRAY 2.5 0.203 0.253 A 291 265 8 0 0 3 [[370, 628]] 1.0 3fqe Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 3FQHB P43405 363 633 635.0 057:2 Type1 None DFGin 6.512 14.384 BLAminus -135.61, -177.0 61.05, 83.05 -100.81, 28.19 289.97, 93.91 -68.13, -27.21 in-in in 7.95 Saltbr-in 2.929 HRD-in -70.78, -57.98 73.35, 4.27 in-in-none SNCiin in-none ActLoopNT-in 2.946 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 140.44 APE9-dihe-in -122.67, 149.45 APE8-dihe-in -71.04, 64.02 APE8-rot-na 27.55 APE67-dihe-in -70.95, -10.14 -42.56, -38.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.931 APE9-dist-in 7.058 None None None XRAY 2.26 0.216 0.259 B 291 258 13 0 0 4 [[370, 628]] 1.0 3fqh Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 3FQSA P43405 363 635 635.0 585:60001 Type1 None DFGin 6.671 15.119 BLAminus -130.1, -168.06 51.07, 81.04 -99.05, 21.72 287.94, 89.19 -65.06, -25.56 in-in in 8.251 Saltbr-in 2.89 HRD-in -73.57, -53.38 73.0, 6.23 in-in-none SNCiin in-none ActLoopNT-in 2.927 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 124.94 APE9-dihe-in -106.74, 133.78 APE8-dihe-in -71.17, 66.53 APE8-rot-na 27.84 APE67-dihe-in -63.27, -16.28 -46.11, -40.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.716 APE9-dist-in 7.49 None None None XRAY 2.1 0.218 0.253 A 291 264 9 0 0 4 [[370, 628]] 1.0 3fqs Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4FYNA P43405 363 635 635.0 0VE:60701 Type1 None DFGin 6.322 14.552 BLAminus -125.05, -173.65 56.58, 84.17 -104.44, 22.0 295.83, 84.03 -64.28, -16.7 in-in in 8.168 Saltbr-in 2.747 HRD-in -77.65, -54.89 74.1, 7.86 in-in-none SNCiin in-none ActLoopNT-in 2.924 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 150.74 APE9-dihe-in -119.38, 130.75 APE8-dihe-in -71.21, 75.44 APE8-rot-na 25.91 APE67-dihe-in -62.88, -14.32 -62.84, -38.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.751 APE9-dist-in 7.34 None None None XRAY 2.318 0.228 0.269 A 291 263 10 0 0 4 [[370, 628]] 1.0 4fyn Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4FYOA P43405 363 635 635.0 0VF:60701 Type1 None DFGin 6.527 14.676 BLAminus -132.65, -177.95 62.23, 72.42 -93.99, 21.12 289.45, 90.18 -61.07, -25.58 in-in in 7.75 Saltbr-in 2.757 HRD-in -74.26, -50.97 72.76, 4.05 in-in-none SNCiin in-none ActLoopNT-in 2.952 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 140.05 APE9-dihe-in -108.11, 144.2 APE8-dihe-in -76.07, 73.27 APE8-rot-na 27.85 APE67-dihe-in -65.29, -14.44 -52.41, -38.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.947 APE9-dist-in 7.308 None None None XRAY 1.4 0.22 0.24 A 291 263 10 0 0 4 [[370, 628]] 1.0 4fyo Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4FZ6A P43405 363 635 635.0 0VG:60701 Type1 None DFGin 6.317 14.691 BLAminus -133.65, -169.74 58.51, 78.15 -100.44, 26.78 291.45, 90.91 -64.04, -31.24 in-in in 8.443 Saltbr-in 3.006 HRD-in -75.46, -52.97 71.45, 4.73 in-in-none SNCiin in-none ActLoopNT-in 2.901 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 139.2 APE9-dihe-in -115.79, 143.14 APE8-dihe-in -76.09, 69.74 APE8-rot-na 28.85 APE67-dihe-in -66.47, -14.43 -53.02, -38.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.466 APE9-dist-in 7.234 None None None XRAY 1.85 0.23 0.253 A 291 262 11 0 0 4 [[370, 628]] 1.0 4fz6 Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4FZ7A P43405 363 635 635.0 0VH:60701 Type1 None DFGin 6.4 14.413 BLAminus -130.24, -170.94 63.54, 68.16 -91.78, 16.19 289.77, 87.77 -59.49, -25.0 in-in in 8.219 Saltbr-in 2.95 HRD-in -74.99, -52.16 71.67, 6.11 in-in-none SNCiin in-none ActLoopNT-in 2.877 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 93.82 APE9-dihe-in -107.75, 152.66 APE8-dihe-in -78.57, 65.92 APE8-rot-na 31.11 APE67-dihe-in -66.21, -17.27 -45.73, -35.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.607 APE9-dist-in 6.901 None None None XRAY 1.75 0.202 0.25 A 291 261 12 0 0 4 [[370, 628]] 1.0 4fz7 Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4I0RA P43405 363 635 635.0 1B4:60701 Type1 None DFGin 6.303 14.472 BLAminus -120.7, -175.74 66.13, 76.03 -99.52, 27.66 293.49, 90.9 -68.19, -27.87 in-in in 8.079 Saltbr-in 2.795 HRD-in -77.52, -55.13 72.71, 3.63 in-in-none SNCiin in-none ActLoopNT-in 2.856 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 132.26 APE9-dihe-in -103.47, 139.74 APE8-dihe-in -70.94, 75.19 APE8-rot-na 28.76 APE67-dihe-in -61.34, -17.47 -59.11, -38.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.727 APE9-dist-in 7.158 None None None XRAY 2.1 0.237 0.272 A 291 260 13 0 0 4 [[370, 628]] 1.0 4i0r Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4I0SA P43405 363 635 635.0 1B5:60701 Type1 None DFGin 6.348 14.318 BLAminus -129.27, -175.27 55.43, 83.6 -98.08, 24.19 289.58, 86.12 -61.12, -27.32 in-in in 8.034 Saltbr-in 2.589 HRD-in -71.15, -52.29 70.43, 7.1 in-in-none SNCiin in-none ActLoopNT-in 2.926 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 126.23 APE9-dihe-in -113.12, 145.51 APE8-dihe-in -74.21, 66.56 APE8-rot-na 27.25 APE67-dihe-in -64.4, -15.49 -48.66, -38.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.673 APE9-dist-in 7.239 None None None XRAY 1.98 0.218 0.236 A 291 263 10 0 0 4 [[370, 628]] 1.0 4i0s Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4PUZA P43405 363 633 635.0 CG9:701 Type1 None DFGin 6.367 14.29 BLAminus -136.54, -176.83 63.98, 77.0 -97.69, 30.02 296.24, 87.49 -65.1, -31.87 in-in in 7.929 Saltbr-in 2.822 HRD-in -73.68, -57.13 77.44, 4.88 in-in-none SNCiin in-none ActLoopNT-in 2.806 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 106.61 APE9-dihe-in -123.49, 140.78 APE8-dihe-in -68.55, 53.64 APE8-rot-na 28.04 APE67-dihe-in -67.84, -11.38 -28.81, -44.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.915 APE9-dist-in 7.237 None None None XRAY 2.085 0.213 0.261 A 291 263 8 0 0 3 [[370, 628]] 1.0 4puz Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4PUZB P43405 363 635 635.0 CG9:701 Type1 None DFGin 6.303 14.273 BLAminus -130.49, 178.11 63.06, 88.54 -109.96, 27.3 298.33, 92.7 -70.91, -20.76 in-in in 7.815 Saltbr-in 2.905 HRD-in -68.83, -56.51 73.59, 10.98 in-in-none SNCiin in-none ActLoopNT-in 2.679 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 100.98 APE9-dihe-in -104.75, 136.54 APE8-dihe-in -73.52, 61.27 APE8-rot-na 28.37 APE67-dihe-in -69.59, -18.44 -38.04, -42.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.414 APE9-dist-in 6.976 None None None XRAY 2.085 0.213 0.261 B 291 265 8 0 0 3 [[370, 628]] 1.0 4puz Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 5T68A P43405 363 635 635.0 77V:60701 Type1 None DFGin 6.399 14.233 BLAminus -118.2, -175.03 55.02, 90.22 -105.11, 31.93 294.35, 102.52 -80.93, -22.27 in-in in 7.864 Saltbr-in 2.767 HRD-in -79.38, -47.76 69.54, -3.58 in-in-none SNCiin in-none ActLoopNT-in 3.07 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -53.8 APE9-dihe-in -121.95, 75.31 APE8-dihe-in -77.88, 51.45 APE8-rot-na 19.76 APE67-dihe-in -78.2, -26.54 -39.48, -21.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.291 APE9-dist-in 7.587 None None None XRAY 2.93 0.188 0.281 A 291 264 9 0 0 4 [[370, 628]] 1.0 5t68 Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 5T68B P43405 363 635 635.0 77V:60701 Type1 None DFGin 6.335 14.549 BLAminus -125.81, -173.18 53.62, 72.36 -90.46, 31.38 289.78, 97.36 -69.64, -47.12 in-in in 7.859 Saltbr-in 2.795 HRD-in -56.8, -40.48 64.3, -8.06 in-in-none SNCiin in-none ActLoopNT-in 2.996 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -66.53 APE9-dihe-in -122.76, 73.0 APE8-dihe-in -76.02, 70.05 APE8-rot-na 29.83 APE67-dihe-in -58.48, -8.81 -36.73, -49.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.244 APE9-dist-in 6.86 None None None XRAY 2.93 0.188 0.281 B 291 264 9 0 0 4 [[370, 628]] 1.0 5t68 Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 5Y5UB P43405 363 629 635.0 8OU:701 Type1 None DFGin 6.322 13.999 BLAminus -136.83, 172.48 60.12, 69.06 -76.3, 17.06 301.14, 79.7 -45.71, -46.86 in-in in 7.647 Saltbr-in 2.798 HRD-in -72.89, -51.34 74.65, -2.0 in-in-none SNCiin in-none ActLoopNT-in 2.821 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 45.91 APE8-rot-na 27.44 APE67-dihe-in -59.42, -23.8 -55.69, -38.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.14 0.239 0.26 B 293 257 10 0 0 6 [[370, 628]] 1.0 5y5u Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 8WYWA P43405 364 633 635.0 XFB:701 Type1 None DFGin 6.237 14.467 BLAminus -132.59, -164.71 66.23, 68.08 -96.88, 23.52 293.79, 90.86 -58.6, -30.92 in-in in 8.046 Saltbr-in 2.8 HRD-in -78.12, -54.08 75.86, 6.55 in-in-none SNCiin in-none ActLoopNT-in 2.953 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 61.34 APE8-rot-na 31.52 APE67-dihe-in -65.01, -13.06 -58.71, -34.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.202 0.242 A 293 264 6 0 0 6 [[370, 628]] 1.0 8wyw Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 8WYWB P43405 365 633 635.0 XFB:701 Type1 None DFGin 6.298 14.432 BLAminus -136.18, -166.23 64.92, 68.41 -94.85, 24.26 293.81, 88.05 -62.54, -27.54 in-in in 8.1 Saltbr-in 2.762 HRD-in -75.21, -53.42 72.9, 5.68 in-in-none SNCiin in-none ActLoopNT-in 2.97 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 56.28 APE8-rot-na 30.56 APE67-dihe-in -70.56, -10.12 -50.08, -35.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.202 0.242 B 293 263 6 0 0 6 [[370, 628]] 1.0 8wyw Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 3VF8A P43405 363 635 635.0 0JE:701 Type1 None DFGin 6.303 14.274 BLAminus -127.47, -170.59 55.16, 83.49 -101.53, 21.98 288.96, 89.41 -58.75, -35.76 in-none in 8.043 Saltbr-none 999.0 HRD-in -73.27, -51.41 67.21, 6.99 none-in-in SNCnii in-in ActLoopNT-in 2.985 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.14, 90.57 APE9-dihe-in -105.62, 138.03 APE8-dihe-in -81.27, 73.81 APE8-rot-na 26.23 APE67-dihe-in -66.47, -16.98 -51.38, -34.52 APE12-dist-na 13.257 APE11-dist-na 10.092 APE10-dist-na 10.007 APE9-dist-in 6.796 None None None XRAY 2.08 0.217 0.241 A 299 265 8 0 0 0 [[370, 628]] 1.0 3vf8 Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 3VF9A P43405 364 635 635.0 477:701 Type1 None DFGin 6.396 14.64 BLAminus -128.07, -174.94 57.37, 81.54 -100.98, 31.05 291.59, 91.29 -68.94, -37.68 in-none in 7.996 Saltbr-none 999.0 HRD-in -72.91, -49.87 65.85, 9.08 none-in-in SNCnii in-in ActLoopNT-in 3.023 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.57, 94.78 APE9-dihe-in -116.96, 141.01 APE8-dihe-in -83.94, 81.53 APE8-rot-na 20.28 APE67-dihe-in -58.58, -19.75 -44.92, -48.84 APE12-dist-na 13.207 APE11-dist-na 10.508 APE10-dist-na 9.877 APE9-dist-in 6.696 None None None XRAY 2.3 0.255 0.267 A 299 265 7 0 0 0 [[370, 628]] 1.0 3vf9 Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 6SSBA P43405 363 635 635.0 LUE:60701 Type1 None DFGin 6.592 14.467 BLAminus -122.14, -172.72 60.63, 82.61 -104.23, 21.05 289.2, 91.73 -65.13, -29.21 in-in in 8.322 Saltbr-in 2.938 HRD-in -79.93, -48.97 63.18, 12.69 in-in-none SNCiin in-none ActLoopNT-in 2.83 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 141.28 APE9-dihe-in -123.27, 130.6 APE8-dihe-in -78.29, 70.91 APE8-rot-na 28.49 APE67-dihe-in -60.55, -20.65 -51.68, -36.02 APE12-dist-na 13.355 APE11-dist-na 999.0 APE10-dist-na 11.696 APE9-dist-in 7.598 None None None XRAY 2.08 0.198 0.225 A 299 265 8 0 0 1 [[370, 628]] 1.0 6ssb Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 6ZCQA P43405 363 635 635.0 QFB:60701 Type1 None DFGin 6.284 14.2 BLAminus -124.06, -169.43 66.04, 72.78 -96.7, 17.81 287.27, 83.52 -60.89, -32.14 in-in in 7.992 Saltbr-in 2.987 HRD-in -74.82, -45.46 62.85, 5.49 in-in-none SNCiin in-none ActLoopNT-in 2.786 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 48.57 APE9-dihe-in -117.91, 130.07 APE8-dihe-in -75.75, 81.23 APE8-rot-na 23.59 APE67-dihe-in -67.53, -16.63 -56.17, -31.85 APE12-dist-na 13.343 APE11-dist-na 999.0 APE10-dist-na 10.663 APE9-dist-in 7.588 None None None XRAY 2.32 0.191 0.244 A 299 265 8 0 0 1 [[370, 628]] 1.0 6zcq Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 6ZCRA P43405 363 635 635.0 5JG:60701 Type1 None DFGin 6.691 14.616 BLAminus -131.25, -174.99 58.52, 82.29 -98.4, 23.45 287.56, 81.54 -60.43, -25.78 in-in in 8.005 Saltbr-in 2.921 HRD-in -78.76, -53.73 70.25, 7.39 in-in-none SNCiin in-none ActLoopNT-in 2.804 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.61 APE8-dihe-in -81.67, 70.3 APE8-rot-na 33.8 APE67-dihe-in -65.02, -14.57 -49.04, -40.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.715 None None None XRAY 1.73 0.189 0.218 A 299 264 9 0 0 4 [[370, 628]] 1.0 6zcr Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 6ZCSA P43405 363 635 635.0 QFE:60701 Type1 None DFGin 6.423 14.516 BLAminus -134.38, -165.15 61.58, 75.97 -101.01, 19.73 286.51, 84.39 -60.24, -29.14 in-in in 8.086 Saltbr-in 2.967 HRD-in -75.9, -52.9 70.28, 10.24 in-in-none SNCiin in-none ActLoopNT-in 2.953 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 129.22 APE9-dihe-in -113.36, 141.08 APE8-dihe-in -78.2, 72.25 APE8-rot-na 29.63 APE67-dihe-in -66.52, -13.86 -50.21, -39.33 APE12-dist-na 13.375 APE11-dist-na 999.0 APE10-dist-na 11.307 APE9-dist-in 7.092 None None None XRAY 1.47 0.191 0.208 A 299 267 6 0 0 1 [[370, 628]] 1.0 6zcs Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 6ZCUA P43405 363 635 635.0 5JG:60701 Type1 None DFGin 6.691 14.616 BLAminus -131.25, -174.99 58.52, 82.29 -98.4, 23.45 287.56, 81.54 -60.43, -25.78 in-in in 8.005 Saltbr-in 2.921 HRD-in -78.76, -53.73 70.25, 7.39 in-in-none SNCiin in-none ActLoopNT-in 2.804 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.61 APE8-dihe-in -81.67, 70.3 APE8-rot-na 33.8 APE67-dihe-in -65.02, -14.57 -49.04, -40.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.715 None None None XRAY 1.73 0.189 0.218 A 299 264 9 0 0 4 [[370, 628]] 1.0 6zcu Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 6ZCXA P43405 363 635 635.0 QFQ:60701 Type1 None DFGin 6.394 14.216 BLAminus -127.67, -173.55 62.06, 69.93 -92.28, 16.27 287.89, 90.74 -57.86, -30.2 in-in in 7.981 Saltbr-in 2.76 HRD-in -77.57, -48.61 68.8, 7.96 in-in-none SNCiin in-none ActLoopNT-in 2.865 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 153.3 APE9-dihe-in -109.71, 136.91 APE8-dihe-in -79.72, 69.78 APE8-rot-na 28.01 APE67-dihe-in -63.91, -15.97 -45.91, -39.08 APE12-dist-na 13.354 APE11-dist-na 999.0 APE10-dist-na 11.597 APE9-dist-in 7.167 None None None XRAY 1.66 0.191 0.229 A 299 263 10 0 0 1 [[370, 628]] 1.0 6zcx Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 6ZCYA P43405 363 635 635.0 QF8:60701 Type1 None DFGin 6.387 14.192 BLAminus -129.73, -170.79 60.52, 70.48 -91.88, 15.3 287.22, 87.41 -58.42, -30.07 in-in in 7.93 Saltbr-in 2.768 HRD-in -74.39, -48.85 68.77, 6.76 in-in-none SNCiin in-none ActLoopNT-in 2.961 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 129.7 APE9-dihe-in -121.42, 129.82 APE8-dihe-in -80.2, 74.63 APE8-rot-na 27.78 APE67-dihe-in -63.99, -16.94 -49.51, -37.22 APE12-dist-na 13.978 APE11-dist-na 999.0 APE10-dist-na 10.367 APE9-dist-in 7.055 None None None XRAY 1.81 0.19 0.223 A 299 263 10 0 0 1 [[370, 628]] 1.0 6zcy Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 8BI2A P43405 363 635 635.0 QR7:60701 Type1 None DFGin 6.391 14.35 BLAminus -125.08, -171.04 64.92, 73.8 -98.47, 21.21 291.51, 90.98 -64.58, -29.05 in-in in 8.176 Saltbr-in 2.889 HRD-in -78.14, -51.69 70.22, 11.64 in-in-none SNCiin in-none ActLoopNT-in 2.905 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 81.28 APE9-dihe-in -115.01, 139.63 APE8-dihe-in -80.07, 71.09 APE8-rot-na 29.24 APE67-dihe-in -64.38, -13.13 -46.76, -40.63 APE12-dist-na 12.701 APE11-dist-na 999.0 APE10-dist-na 9.938 APE9-dist-in 7.007 None None None XRAY 1.508 0.205 0.235 A 299 264 9 0 0 1 [[370, 628]] 1.0 8bi2 Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 5CXZA P43405 363 635 635.0 55U:60703 Type1 None DFGin 6.539 14.365 BLAminus -122.74, -171.85 60.83, 74.48 -94.07, 15.61 289.21, 94.41 -56.97, -30.72 in-in in 7.953 Saltbr-in 2.818 HRD-in -72.21, -54.6 71.31, 11.0 in-in-none SNCiin in-none ActLoopNT-in 2.994 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 104.14 APE9-dihe-in -107.14, 142.58 APE8-dihe-in -80.12, 71.68 APE8-rot-na 30.9 APE67-dihe-in -65.83, -15.68 -54.56, -35.41 APE12-dist-na 13.509 APE11-dist-na 999.0 APE10-dist-na 11.349 APE9-dist-in 7.132 K467T None None XRAY 1.7 0.195 0.208 A 289 267 6 0 0 1 [[370, 628]] 1.0 5cxz Homo sapiens TYR_SYK_HUMAN TYR 3.9e-90 307.6 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
KSYK_HUMAN 4PX6A P43405 364 635 635.0 2X6:60701 Type1 None DFGin 6.596 14.557 BLAminus -133.62, -172.86 59.0, 67.69 -88.07, 18.86 287.15, 91.9 -59.4, -27.39 in-in in 7.764 Saltbr-in 2.803 HRD-in -78.31, -51.2 71.98, 5.54 in-in-none SNCiin in-none ActLoopNT-in 2.934 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 131.68 APE9-dihe-in -102.64, 145.76 APE8-dihe-in -78.83, 69.49 APE8-rot-na 28.48 APE67-dihe-in -64.5, -16.03 -45.05, -41.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.958 APE9-dist-in 7.353 K467T None None XRAY 1.6 0.176 0.202 A 291 261 11 0 0 4 [[370, 628]] 1.0 4px6 Homo sapiens TYR_SYK_HUMAN TYR 4e-90 307.6 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK

TYR_SYK (Tyrosine-protein kinase SYK)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name