TYR_SYK (Tyrosine-protein kinase SYK)

Total number of chains: 103
Active chains: 36
Uniprot: KSYK_HUMAN
Kinase Domain Residues: 370 - 628
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 98 95.1% AF-P43405-K1A
DFGin BLBplus 3 2.9% 4FL2A
DFGout BBAminus 1 1.0% 3TUBA
DFGout None 1 1.0% 3TUDA

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
SYK 4FL1A P43405 363 635 635.0 ANP:701 ATPlike Active DFGin 6.6692 15.0632 BLAminus -122.6, -175.53 56.16, 78.38 -92.62, 24.67 287.04, 93.75 -57.67, -38.36 in-in in 8.0588 Saltbr-in 2.6833 HRD-in -76.27, -50.57 71.77, 3.28 in-in-in SNCiii in-in ActLoopNT-in 2.9759 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.55, 85.11 APE9-dihe-in -99.28, 138.37 APE8-dihe-in -79.64, 69.72 APE8-rot-na 29.68 APE67-dihe-in -60.65, -16.95 -44.16, -41.68 APE12-dist-na 13.8161 APE11-dist-na 10.806 APE10-dist-na 10.4124 APE9-dist-in 7.1318 None None None XRAY 1.79 0.197 0.225 A 291.0 268.0 5 31 31 0 [[370, 628]] 1.0 4fl1 TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK AF-P43405-K1A P43405 362 635 635.0 No_ligand No_ligand Active DFGin 6.555 14.2826 BLAminus -139.44, 178.99 59.92, 76.86 -92.13, 11.74 288.31, 88.77 -62.73, -28.38 in-in in 8.2953 Saltbr-in 2.6504 HRD-in -79.06, -42.92 61.69, 3.61 in-in-in SNCiii in-in ActLoopNT-in 2.8958 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.91, 86.51 APE9-dihe-in -86.43, 140.76 APE8-dihe-in -76.46, 66.17 APE8-rot-na 36.18 APE67-dihe-in -68.53, -16.84 -44.81, -36.23 APE12-dist-na 14.0823 APE11-dist-na 9.8667 APE10-dist-na 10.6208 APE9-dist-in 6.9529 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 31 31 0 [[370, 628]] 1.0 AF-P43405-K1 TYR_SYK_HUMAN TYR 4.4e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK AF-P43405-K3A P43405 362 635 635.0 No_ligand No_ligand Active DFGin 6.251 14.4217 BLAminus -144.99, -179.8 59.41, 72.04 -85.9, 11.12 288.49, 84.65 -61.31, -25.31 in-in in 8.4775 Saltbr-in 2.7021 HRD-in -76.05, -44.23 63.83, -5.43 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.2, 83.8 APE9-dihe-in -94.84, 151.9 APE8-dihe-in -77.3, 64.33 APE8-rot-na 36.0 APE67-dihe-in -67.48, -13.27 -45.03, -34.91 APE12-dist-na 14.3541 APE11-dist-na 10.3178 APE10-dist-na 11.5647 APE9-dist-in 7.1916 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 31 31 0 [[370, 628]] 1.0 AF-P43405-K3 TYR_SYK_HUMAN TYR 4.4e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 1XBAA P43405 363 635 635.0 No_ligand No_ligand Active DFGin 6.2832 14.3878 BLAminus -126.49, -176.52 55.21, 85.12 -100.47, 21.0 289.26, 85.99 -66.46, -29.63 in-in in 7.9237 Saltbr-in 3.2803 HRD-in -79.13, -52.49 65.3, 12.61 in-in-in SNCiii in-in ActLoopNT-in 2.7688 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.47, 98.05 APE9-dihe-in -115.59, 139.53 APE8-dihe-in -72.13, 70.06 APE8-rot-na 26.48 APE67-dihe-in -72.34, -11.74 -55.87, -33.02 APE12-dist-na 13.3709 APE11-dist-na 9.5361 APE10-dist-na 9.8853 APE9-dist-in 6.4759 None None None XRAY 2.0 0.231 0.278 A 291.0 265.0 8 31 31 0 [[370, 628]] 1.0 1xba TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4F4PA P43405 365 635 635.0 0SB:60701 Type1 Active DFGin 6.3733 14.5391 BLAminus -124.15, 178.53 62.38, 80.95 -106.72, 25.8 293.21, 86.39 -66.32, -31.8 in-in in 8.3369 Saltbr-in 3.5473 HRD-in -76.55, -51.58 69.18, 8.78 in-in-in SNCiii in-in ActLoopNT-in 2.9954 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.78, 99.03 APE9-dihe-in -104.94, 133.88 APE8-dihe-in -73.17, 77.69 APE8-rot-na 29.01 APE67-dihe-in -66.28, -12.67 -56.63, -36.73 APE12-dist-na 13.3146 APE11-dist-na 9.5636 APE10-dist-na 10.4225 APE9-dist-in 6.8712 None None None XRAY 2.37 0.241 0.285 A 273.0 260.0 11 31 31 0 [[370, 628]] 1.0 4f4p TYR_SYK_HUMAN TYR 4.3e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4DFNA P43405 363 635 635.0 0K1:60701 Type1 Active DFGin 6.4903 14.4545 BLAminus -130.15, -170.0 61.62, 83.88 -107.34, 23.58 294.6, 91.76 -72.41, -22.45 in-in in 8.746 Saltbr-in 3.1828 HRD-in -85.27, -46.79 70.7, 5.96 in-in-in SNCiii in-in ActLoopNT-in 3.006 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.4, 98.4 APE9-dihe-in -102.46, 134.32 APE8-dihe-in -74.07, 82.6 APE8-rot-na 30.43 APE67-dihe-in -65.57, -16.86 -58.25, -34.59 APE12-dist-na 13.6546 APE11-dist-na 10.7083 APE10-dist-na 11.3247 APE9-dist-in 7.3012 None None None XRAY 2.48 0.222 0.273 A 274.0 268.0 5 31 31 0 [[370, 628]] 1.0 4dfn TYR_SYK_HUMAN TYR 4.4e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4PV0A P43405 363 635 635.0 CG4:60701 Type1 Active DFGin 6.4011 14.6067 BLAminus -130.2, -175.25 67.21, 78.78 -101.45, 20.11 290.66, 99.39 -65.44, -27.35 in-in in 8.4663 Saltbr-in 3.4401 HRD-in -78.38, -54.31 73.62, 9.17 in-in-in SNCiii in-in ActLoopNT-in 2.8351 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.94, 106.38 APE9-dihe-in -116.79, 139.9 APE8-dihe-in -79.38, 71.94 APE8-rot-na 33.78 APE67-dihe-in -68.26, -13.59 -53.62, -38.3 APE12-dist-na 13.1611 APE11-dist-na 9.8666 APE10-dist-na 10.488 APE9-dist-in 6.9382 None None None XRAY 2.0 0.231 0.282 A 275.0 266.0 7 31 31 0 [[370, 628]] 1.0 4pv0 TYR_SYK_HUMAN TYR 4.5e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 6HM6A P43405 364 632 635.0 GDK:701 Type1 Active DFGin 6.5096 14.7161 BLAminus -135.72, 178.12 60.9, 85.59 -101.68, 17.9 294.15, 88.35 -56.95, -33.53 in-in in 8.2553 Saltbr-in 2.9855 HRD-in -76.78, -53.52 71.64, 11.57 in-in-in SNCiii in-in ActLoopNT-in 2.9174 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -60.26, 138.11 APE9-dihe-in -138.15, 72.71 APE8-dihe-in -77.49, 77.46 APE8-rot-na 32.95 APE67-dihe-in -66.81, -17.94 -54.41, -33.99 APE12-dist-na 999.0 APE11-dist-na 9.2391 APE10-dist-na 7.7529 APE9-dist-in 7.6681 None PTR525 PTR525 XRAY 2.1 0.217 0.29 A 276.0 261.0 8 31 29 2 [[370, 628]] 1.0 6hm6 TYR_SYK_HUMAN TYR 4.5e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 3SRVA P43405 364 634 635.0 S19:1 Type1 Active DFGin 6.2782 14.0241 BLAminus -137.61, -172.24 65.42, 72.28 -96.27, 25.84 296.23, 89.02 -63.12, -26.69 in-in in 7.7479 Saltbr-in 2.717 HRD-in -84.44, -49.93 72.25, 5.56 in-in-in SNCiii in-in ActLoopNT-in 2.9734 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.48, 113.26 APE9-dihe-in -101.68, 153.86 APE8-dihe-in -78.64, 68.9 APE8-rot-na 34.87 APE67-dihe-in -67.25, -14.96 -56.26, -32.84 APE12-dist-na 12.9309 APE11-dist-na 10.491 APE10-dist-na 11.935 APE9-dist-in 7.2164 None PTR525 PTR525 XRAY 1.95 0.188 0.241 A 277.0 263.0 8 31 31 0 [[370, 628]] 1.0 3srv TYR_SYK_HUMAN TYR 4.6e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 3SRVB P43405 364 632 635.0 S19:2 Type1 Active DFGin 6.2831 14.2364 BLAminus -130.89, -171.96 62.47, 72.82 -96.45, 25.83 293.72, 91.52 -65.61, -26.16 in-in in 7.6629 Saltbr-in 2.9666 HRD-in -72.4, -57.08 74.0, 8.38 in-in-in SNCiii in-in ActLoopNT-in 2.9744 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -91.35, 90.32 APE9-dihe-in -97.42, 146.07 APE8-dihe-in -79.19, 69.07 APE8-rot-na 34.2 APE67-dihe-in -70.71, -15.69 -52.0, -32.14 APE12-dist-na 13.2109 APE11-dist-na 10.2607 APE10-dist-na 10.8708 APE9-dist-in 6.9838 None None None XRAY 1.95 0.188 0.241 B 277.0 263.0 6 31 31 0 [[370, 628]] 1.0 3srv TYR_SYK_HUMAN TYR 4.6e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 5LMAA P43405 363 632 635.0 6ZG:701 Type1 Active DFGin 6.7076 14.7541 BLAminus -128.5, -174.48 63.43, 65.54 -91.18, 18.15 286.4, 81.6 -62.6, -20.77 in-in in 8.0008 Saltbr-in 2.7693 HRD-in -78.56, -50.71 72.45, 5.63 in-in-in SNCiii in-in ActLoopNT-in 2.9274 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -59.08, 136.12 APE9-dihe-in -133.37, 70.56 APE8-dihe-in -71.66, 73.32 APE8-rot-na 31.65 APE67-dihe-in -63.61, -19.89 -49.48, -39.64 APE12-dist-na 999.0 APE11-dist-na 9.2116 APE10-dist-na 7.6988 APE9-dist-in 7.6222 None PTR525 PTR525 XRAY 1.43 0.157 0.183 A 277.0 268.0 2 31 29 2 [[370, 628]] 1.0 5lma TYR_SYK_HUMAN TYR 4.6e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 5LMBA P43405 364 634 635.0 6ZF:701 Type1 Active DFGin 6.4476 14.2826 BLAminus -131.02, -173.87 62.28, 69.39 -93.16, 19.0 290.08, 82.25 -59.68, -28.46 in-in in 7.6957 Saltbr-in 2.454 HRD-in -78.06, -53.9 76.38, 4.89 in-in-in SNCiii in-in ActLoopNT-in 2.9631 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.66, 104.96 APE9-dihe-in -108.73, 152.4 APE8-dihe-in -79.7, 70.25 APE8-rot-na 31.84 APE67-dihe-in -69.34, -16.13 -51.43, -34.69 APE12-dist-na 13.0735 APE11-dist-na 10.546 APE10-dist-na 11.4482 APE9-dist-in 6.9588 None PTR525 PTR525 XRAY 1.95 0.178 0.228 A 277.0 265.0 6 31 31 0 [[370, 628]] 1.0 5lmb TYR_SYK_HUMAN TYR 4.6e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 6VOVB P43405 364 633 635.0 R6D:701 Type1 Active DFGin 6.6739 14.6282 BLAminus -133.89, -172.81 60.07, 70.15 -88.26, 20.03 288.32, 89.62 -58.86, -27.32 in-in in 8.0798 Saltbr-in 2.6221 HRD-in -78.67, -51.68 71.89, 6.23 in-in-in SNCiii in-in ActLoopNT-in 2.8816 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.76, 97.82 APE9-dihe-in -115.45, 146.07 APE8-dihe-in -78.23, 69.53 APE8-rot-na 28.65 APE67-dihe-in -63.96, -14.94 -44.81, -41.99 APE12-dist-na 13.6462 APE11-dist-na 10.4481 APE10-dist-na 11.0328 APE9-dist-in 6.8137 None None None XRAY 1.95 0.22 0.268 B 281.0 264.0 6 31 31 0 [[370, 628]] 1.0 6vov TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4YJOA P43405 363 632 635.0 4DF:701 Type1 Active DFGin 7.1511 15.4037 BLAminus -136.57, 178.57 59.58, 80.7 -95.16, 22.65 286.36, 75.19 -55.96, -31.16 in-in in 8.3198 Saltbr-in 3.0437 HRD-in -80.48, -52.4 72.29, 6.84 in-in-in SNCiii in-in ActLoopNT-in 2.9567 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.5, 127.44 APE9-dihe-in -144.08, 83.31 APE8-dihe-in -75.74, 70.97 APE8-rot-na 33.07 APE67-dihe-in -63.43, -16.56 -52.99, -37.5 APE12-dist-na 999.0 APE11-dist-na 10.63 APE10-dist-na 7.9003 APE9-dist-in 7.5071 None None None XRAY 1.6 0.186 0.23 A 281.0 267.0 3 31 28 3 [[370, 628]] 1.0 4yjo TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4YJPA P43405 364 632 635.0 4DL:701 Type1 Active DFGin 6.9808 15.8243 BLAminus -136.12, -172.87 58.52, 69.5 -93.88, 23.3 283.25, 78.78 -63.0, -28.48 in-in in 8.4993 Saltbr-in 2.7873 HRD-in -81.51, -48.52 67.75, 7.04 in-in-in SNCiii in-in ActLoopNT-in 2.9447 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -52.7, 125.7 APE9-dihe-in -135.05, 78.45 APE8-dihe-in -76.25, 75.65 APE8-rot-na 35.36 APE67-dihe-in -66.34, -13.74 -58.49, -30.71 APE12-dist-na 999.0 APE11-dist-na 9.4522 APE10-dist-na 7.3693 APE9-dist-in 7.2569 None None None XRAY 1.83 0.196 0.258 A 281.0 263.0 6 31 28 3 [[370, 628]] 1.0 4yjp TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4YJSA P43405 364 632 635.0 4DN:701 Type1 Active DFGin 6.8114 15.7399 BLAminus -130.65, -173.59 54.32, 75.2 -95.58, 22.43 287.83, 71.53 -54.84, -38.21 in-in in 8.5143 Saltbr-in 3.0836 HRD-in -80.45, -49.01 70.65, 8.19 in-in-in SNCiii in-in ActLoopNT-in 2.8965 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -50.21, 136.65 APE9-dihe-in -143.79, 77.69 APE8-dihe-in -76.44, 79.91 APE8-rot-na 34.0 APE67-dihe-in -64.44, -15.73 -58.23, -33.75 APE12-dist-na 13.0696 APE11-dist-na 9.2243 APE10-dist-na 7.474 APE9-dist-in 7.0682 None None None XRAY 2.22 0.172 0.226 A 281.0 257.0 12 31 31 0 [[370, 628]] 1.0 4yjs TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 8RRQA P43405 363 632 635.0 A1H2W:701 Type1 Active DFGin 6.2148 14.4112 BLAminus -133.38, -167.55 71.76, 65.57 -94.48, 19.17 287.36, 93.75 -65.47, -22.18 in-in in 8.0815 Saltbr-in 2.8031 HRD-in -81.18, -51.78 70.8, 9.1 in-in-in SNCiii in-in ActLoopNT-in 2.9421 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.09, 108.93 APE9-dihe-in -135.72, 149.25 APE8-dihe-in -81.85, 69.97 APE8-rot-na 37.74 APE67-dihe-in -65.72, -15.06 -52.32, -34.71 APE12-dist-na 999.0 APE11-dist-na 10.2241 APE10-dist-na 10.5738 APE9-dist-in 6.7427 None PTR525,PTR526 PTR525,PTR526 XRAY 1.6 0.178 0.211 A 282.0 268.0 2 31 29 2 [[370, 628]] 1.0 8rrq TYR_SYK_HUMAN TYR 4.9e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 5TT7A P43405 358 635 635.0 7KF:60901 Type1 Active DFGin 6.3107 14.3414 BLAminus -130.62, -177.29 62.11, 72.82 -94.96, 21.67 289.95, 80.8 -60.6, -26.94 in-in in 7.7094 Saltbr-in 2.8404 HRD-in -77.7, -52.28 69.96, 13.2 in-in-in SNCiii in-in ActLoopNT-in 2.8781 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.65, 88.09 APE9-dihe-in -107.14, 140.48 APE8-dihe-in -78.3, 78.38 APE8-rot-na 32.04 APE67-dihe-in -64.56, -15.37 -56.64, -35.35 APE12-dist-na 13.888 APE11-dist-na 10.557 APE10-dist-na 10.3425 APE9-dist-in 6.8486 None None None XRAY 1.77 0.208 0.234 A 289.0 270.0 8 31 31 0 [[370, 628]] 1.0 5tt7 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 8XQ0A P43405 364 634 635.0 A1LV4:701 Type1 Active DFGin 6.1538 14.7431 BLAminus -131.25, -165.27 59.08, 66.28 -91.94, 24.84 295.79, 89.46 -66.54, -26.0 in-in in 8.8405 Saltbr-in 2.3901 HRD-in -77.49, -50.4 67.59, 11.98 in-in-in SNCiii in-in ActLoopNT-in 2.7629 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.4, 148.65 APE9-dihe-in -142.22, 83.4 APE8-dihe-in -79.88, 80.85 APE8-rot-na 30.05 APE67-dihe-in -71.39, -10.32 -63.91, -29.36 APE12-dist-na 999.0 APE11-dist-na 8.6608 APE10-dist-na 7.4649 APE9-dist-in 7.0838 None None None XRAY 1.95 0.222 0.265 A 290.0 264.0 7 31 27 4 [[370, 628]] 1.0 8xq0 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 8XQ0C P43405 364 633 635.0 A1LV4:701 Type1 Active DFGin 6.0637 14.7714 BLAminus -131.08, -166.05 60.61, 65.77 -92.17, 22.95 297.06, 91.43 -65.35, -22.59 in-in in 8.197 Saltbr-in 2.4741 HRD-in -81.66, -50.49 70.19, 9.23 in-in-in SNCiii in-in ActLoopNT-in 2.8624 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.0, 152.43 APE9-dihe-in -139.04, 83.13 APE8-dihe-in -80.21, 76.04 APE8-rot-na 29.28 APE67-dihe-in -67.25, -12.04 -57.38, -34.01 APE12-dist-na 999.0 APE11-dist-na 8.5474 APE10-dist-na 7.75 APE9-dist-in 7.1856 None None None XRAY 1.95 0.222 0.265 C 290.0 263.0 7 31 28 3 [[370, 628]] 1.0 8xq0 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 1XBCA P43405 363 635 635.0 STU:60001 Type1 Active DFGin 6.6992 14.2365 BLAminus -133.2, -171.25 54.9, 81.04 -97.63, 25.87 287.7, 80.31 -62.67, -30.77 in-in in 8.107 Saltbr-in 2.6812 HRD-in -73.91, -54.08 72.64, 5.62 in-in-in SNCiii in-in ActLoopNT-in 2.8734 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.93, 102.31 APE9-dihe-in -115.14, 122.86 APE8-dihe-in -77.21, 74.28 APE8-rot-na 27.13 APE67-dihe-in -62.04, -14.77 -51.56, -42.64 APE12-dist-na 10.2255 APE11-dist-na 10.6613 APE10-dist-na 9.591 APE9-dist-in 6.8302 None None None XRAY 2.0 0.246 0.294 A 291.0 267.0 6 31 31 0 [[370, 628]] 1.0 1xbc TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 3FQHA P43405 363 634 635.0 057:1 Type1 Active DFGin 6.3887 14.2934 BLAminus -136.21, -174.07 56.01, 83.39 -99.37, 22.02 289.52, 83.78 -53.8, -32.62 in-in in 7.9894 Saltbr-in 2.9827 HRD-in -76.47, -53.05 70.67, 6.23 in-in-in SNCiii in-in ActLoopNT-in 2.7712 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.93, 113.08 APE9-dihe-in -110.56, 145.62 APE8-dihe-in -76.43, 69.28 APE8-rot-na 29.47 APE67-dihe-in -67.72, -12.14 -50.67, -39.65 APE12-dist-na 12.19 APE11-dist-na 10.4595 APE10-dist-na 11.2703 APE9-dist-in 6.9934 None None None XRAY 2.26 0.216 0.259 A 291.0 262.0 10 31 31 0 [[370, 628]] 1.0 3fqh TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4GFGA P43405 363 635 635.0 0XF:60701 Type1 Active DFGin 6.3816 14.7063 BLAminus -133.41, -165.6 61.44, 68.78 -94.44, 29.51 290.84, 74.86 -64.09, -30.1 in-in in 8.5511 Saltbr-in 3.4972 HRD-in -86.12, -47.8 68.36, 5.25 in-in-in SNCiii in-in ActLoopNT-in 2.8664 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -53.12, 138.6 APE9-dihe-in -110.15, 137.21 APE8-dihe-in -65.63, 68.92 APE8-rot-na 25.72 APE67-dihe-in -68.08, -17.47 -52.98, -35.53 APE12-dist-na 9.5817 APE11-dist-na 10.6292 APE10-dist-na 11.7062 APE9-dist-in 7.231 None None None XRAY 2.35 0.221 0.246 A 291.0 273.0 0 31 31 0 [[370, 628]] 1.0 4gfg TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 5TIUA P43405 363 635 635.0 7CU:60701 Type1 Active DFGin 6.578 14.3657 BLAminus -131.38, -173.31 61.91, 73.7 -95.93, 19.79 288.63, 86.78 -61.17, -26.75 in-in in 7.8012 Saltbr-in 2.7346 HRD-in -74.96, -48.82 70.27, 6.32 in-in-in SNCiii in-in ActLoopNT-in 2.9019 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.61, 84.89 APE9-dihe-in -101.52, 144.24 APE8-dihe-in -80.61, 68.84 APE8-rot-na 28.9 APE67-dihe-in -65.13, -16.04 -45.65, -40.25 APE12-dist-na 13.9624 APE11-dist-na 10.8435 APE10-dist-na 10.6887 APE9-dist-in 7.0997 None None None XRAY 1.49 0.186 0.203 A 291.0 262.0 11 31 31 0 [[370, 628]] 1.0 5tiu TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 5Y5TA P43405 363 635 635.0 8OR:701 Type1 Active DFGin 6.6305 14.7164 BLAminus -124.89, -179.45 65.71, 71.78 -93.94, 17.9 289.28, 88.8 -59.66, -30.83 in-in in 8.0451 Saltbr-in 2.706 HRD-in -76.54, -52.99 73.97, 1.93 in-in-in SNCiii in-in ActLoopNT-in 2.9217 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -91.38, 59.43 APE9-dihe-in -101.74, 134.18 APE8-dihe-in -79.02, 75.85 APE8-rot-na 32.57 APE67-dihe-in -64.44, -15.76 -52.79, -38.69 APE12-dist-na 8.8122 APE11-dist-na 11.9308 APE10-dist-na 9.7116 APE9-dist-in 6.9908 None None None XRAY 1.8 0.196 0.234 A 293.0 263.0 10 31 31 0 [[370, 628]] 1.0 5y5t TYR_SYK_HUMAN TYR 5.7e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 5Y5UA P43405 364 634 635.0 8OU:701 Type1 Active DFGin 6.4344 14.0988 BLAminus -136.65, 173.94 66.9, 89.62 -105.43, 28.84 296.27, 90.39 -60.97, -30.93 in-in in 7.9941 Saltbr-in 2.5848 HRD-in -70.93, -52.74 73.81, 2.31 in-in-in SNCiii in-in ActLoopNT-in 2.7997 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.85, 121.36 APE9-dihe-in -125.49, 151.88 APE8-dihe-in -80.17, 69.97 APE8-rot-na 36.19 APE67-dihe-in -65.59, -17.51 -56.34, -35.15 APE12-dist-na 13.3247 APE11-dist-na 10.8666 APE10-dist-na 11.8021 APE9-dist-in 7.2259 None None None XRAY 2.14 0.239 0.26 A 293.0 266.0 5 31 31 0 [[370, 628]] 1.0 5y5u TYR_SYK_HUMAN TYR 5.7e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4WNMA P43405 347 635 635.0 3RT:60701 Type1 Active DFGin 6.2685 14.2043 BLAminus -122.7, 177.9 75.28, 74.2 -103.7, 21.48 302.37, 85.65 -56.81, -27.59 in-in in 8.2793 Saltbr-in 2.749 HRD-in -73.5, -57.83 70.01, 16.8 in-in-in SNCiii in-in ActLoopNT-in 2.8697 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -49.99, 114.81 APE9-dihe-in -116.39, 136.86 APE8-dihe-in -71.67, 69.27 APE8-rot-na 29.91 APE67-dihe-in -63.86, -22.22 -60.87, -29.91 APE12-dist-na 12.4085 APE11-dist-na 9.7166 APE10-dist-na 10.7384 APE9-dist-in 7.1211 None None None XRAY 2.5 0.207 0.26 A 299.0 272.0 4 31 31 0 [[370, 628]] 1.0 4wnm TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 5C26A P43405 363 635 635.0 50H:60701 Type1 Active DFGin 6.4069 14.9052 BLAminus -133.47, -175.05 59.93, 80.73 -95.24, 23.48 291.98, 89.4 -57.38, -35.1 in-in in 8.2315 Saltbr-in 2.7559 HRD-in -77.18, -53.12 70.55, 7.56 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.23, 98.53 APE9-dihe-in -110.63, 147.85 APE8-dihe-in -78.58, 69.25 APE8-rot-na 30.18 APE67-dihe-in -65.45, -18.57 -48.55, -37.73 APE12-dist-na 13.3107 APE11-dist-na 10.5734 APE10-dist-na 10.5924 APE9-dist-in 6.8401 None PTR525,PTR526 PTR525,PTR526 XRAY 1.95 0.186 0.215 A 299.0 273.0 0 31 31 0 [[370, 628]] 1.0 5c26 TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 5C27A P43405 363 635 635.0 50J:60701 Type1 Active DFGin 6.3587 14.6118 BLAminus -130.06, -175.69 60.48, 84.21 -100.61, 25.88 296.18, 90.13 -67.7, -23.97 in-in in 8.3245 Saltbr-in 2.7902 HRD-in -75.03, -53.41 71.91, 4.7 in-in-in SNCiii in-in ActLoopNT-in 3.0014 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.32, 89.13 APE9-dihe-in -103.36, 145.0 APE8-dihe-in -82.82, 67.41 APE8-rot-na 29.25 APE67-dihe-in -67.99, -14.11 -44.6, -40.88 APE12-dist-na 13.3733 APE11-dist-na 10.0379 APE10-dist-na 10.0822 APE9-dist-in 6.7508 None PTR525,PTR526 PTR525,PTR526 XRAY 2.15 0.179 0.225 A 299.0 273.0 0 31 31 0 [[370, 628]] 1.0 5c27 TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 6ZC0A P43405 363 635 635.0 QDZ:60701 Type1 Active DFGin 6.4395 14.2562 BLAminus -134.4, -168.89 64.15, 77.73 -98.13, 17.43 287.82, 84.9 -56.42, -33.19 in-in in 7.8053 Saltbr-in 3.3022 HRD-in -74.71, -54.58 68.95, 18.65 in-in-in SNCiii in-in ActLoopNT-in 2.8699 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.33, 89.82 APE9-dihe-in -113.19, 137.33 APE8-dihe-in -88.05, 72.58 APE8-rot-na 31.66 APE67-dihe-in -60.74, -19.2 -42.14, -42.2 APE12-dist-na 13.5898 APE11-dist-na 10.0879 APE10-dist-na 9.2847 APE9-dist-in 6.8334 None None None XRAY 1.97 0.194 0.229 A 299.0 264.0 9 31 31 0 [[370, 628]] 1.0 6zc0 TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 6ZCPA P43405 363 635 635.0 QFK:60701 Type1 Active DFGin 6.4336 14.1142 BLAminus -125.39, -166.55 56.04, 77.4 -99.95, 22.28 287.9, 88.75 -70.24, -19.9 in-in in 8.0898 Saltbr-in 3.2303 HRD-in -73.61, -47.62 64.51, 7.94 in-in-in SNCiii in-in ActLoopNT-in 2.9329 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.33, 97.29 APE9-dihe-in -119.56, 130.58 APE8-dihe-in -81.48, 76.65 APE8-rot-na 28.01 APE67-dihe-in -69.79, -11.02 -50.04, -33.72 APE12-dist-na 13.9828 APE11-dist-na 11.0182 APE10-dist-na 10.323 APE9-dist-in 7.2576 None None None XRAY 2.2 0.213 0.234 A 299.0 264.0 9 31 31 0 [[370, 628]] 1.0 6zcp TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4RX7A P43405 363 635 635.0 3YV:60703 Type1 Active DFGin 6.3677 14.5099 BLAminus -135.93, -162.06 57.15, 54.11 -83.47, 19.55 290.31, 87.83 -58.61, -26.4 in-in in 8.1507 Saltbr-in 2.9061 HRD-in -74.07, -52.97 72.74, 4.77 in-in-in SNCiii in-in ActLoopNT-in 2.9294 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.3, 124.77 APE9-dihe-in -107.76, 142.43 APE8-dihe-in -82.91, 72.86 APE8-rot-na 31.05 APE67-dihe-in -64.64, -19.89 -48.22, -37.19 APE12-dist-na 12.6465 APE11-dist-na 10.9772 APE10-dist-na 11.2212 APE9-dist-in 7.1341 None None None XRAY 1.8 0.182 0.203 A 289.0 270.0 3 31 31 0 [[370, 628]] 1.0 4rx7 TYR_SYK_HUMAN TYR 3.9e-90 307.6 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4RX8A P43405 364 635 635.0 3YX:60703 Type1 Active DFGin 6.3748 14.3435 BLAminus -127.63, -170.0 62.54, 75.55 -100.59, 22.48 287.33, 90.81 -63.45, -25.44 in-in in 8.0344 Saltbr-in 2.8413 HRD-in -76.4, -50.39 68.53, 9.44 in-in-in SNCiii in-in ActLoopNT-in 2.9288 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.6, 95.02 APE9-dihe-in -111.13, 149.03 APE8-dihe-in -81.54, 69.96 APE8-rot-na 29.76 APE67-dihe-in -66.91, -14.89 -51.35, -37.09 APE12-dist-na 999.0 APE11-dist-na 10.7148 APE10-dist-na 10.6212 APE9-dist-in 6.9816 None None None XRAY 1.59 0.175 0.207 A 289.0 266.0 6 31 30 1 [[370, 628]] 1.0 4rx8 TYR_SYK_HUMAN TYR 3.9e-90 307.6 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 5CXHA P43405 363 635 635.0 55M:60701 Type1 Active DFGin 6.4399 14.3226 BLAminus -133.42, -179.45 56.74, 83.68 -97.45, 24.47 292.79, 86.46 -58.74, -36.41 in-in in 7.6617 Saltbr-in 2.8584 HRD-in -70.81, -53.82 70.99, 7.51 in-in-in SNCiii in-in ActLoopNT-in 2.9745 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.96, 96.35 APE9-dihe-in -104.24, 139.79 APE8-dihe-in -78.53, 71.61 APE8-rot-na 29.83 APE67-dihe-in -66.63, -19.71 -51.23, -33.62 APE12-dist-na 13.1233 APE11-dist-na 10.8367 APE10-dist-na 10.8797 APE9-dist-in 7.0521 K467T None None XRAY 1.9 0.176 0.205 A 289.0 273.0 0 31 31 0 [[370, 628]] 1.0 5cxh TYR_SYK_HUMAN TYR 3.9e-90 307.6 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4RX9A P43405 363 635 635.0 3YT:60702 Type1 Active DFGin 6.5363 14.4979 BLAminus -131.55, -166.02 53.8, 76.49 -95.21, 18.16 288.88, 90.96 -57.69, -29.73 in-in in 8.1675 Saltbr-in 3.1254 HRD-in -77.32, -52.67 70.66, 10.77 in-in-in SNCiii in-in ActLoopNT-in 2.9602 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.14, 87.16 APE9-dihe-in -107.75, 147.74 APE8-dihe-in -79.62, 70.69 APE8-rot-na 28.2 APE67-dihe-in -66.03, -15.15 -48.72, -38.82 APE12-dist-na 999.0 APE11-dist-na 11.0764 APE10-dist-na 10.7611 APE9-dist-in 6.9972 None None None XRAY 1.75 0.175 0.197 A 290.0 264.0 9 31 30 1 [[370, 628]] 1.0 4rx9 TYR_SYK_HUMAN TYR 4e-90 307.6 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 5CY3A P43405 360 635 635.0 55Y:60701 Type1 Active DFGin 6.2954 14.6111 BLAminus -132.49, 178.84 54.8, 80.29 -90.47, 18.93 290.07, 88.96 -55.0, -39.22 in-in in 8.1966 Saltbr-in 2.7629 HRD-in -80.6, -49.34 69.47, 8.41 in-in-in SNCiii in-in ActLoopNT-in 2.9491 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.58, 101.42 APE9-dihe-in -106.21, 146.28 APE8-dihe-in -84.7, 72.08 APE8-rot-na 31.82 APE67-dihe-in -66.44, -12.67 -53.8, -35.38 APE12-dist-na 13.3826 APE11-dist-na 10.3613 APE10-dist-na 10.9874 APE9-dist-in 7.136 K467T None None XRAY 1.76 0.171 0.195 A 291.0 274.0 2 31 31 0 [[370, 628]] 1.0 5cy3 TYR_SYK_HUMAN TYR 4e-90 307.6 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4DFLA P43405 363 635 635.0 0K0:60701 Type1 Inactive DFGin 6.483 14.5712 BLAminus -118.07, -176.51 65.46, 77.03 -97.43, 24.23 290.23, 82.73 -67.62, -27.84 in-in in 8.4441 Saltbr-in 3.1343 HRD-in -79.8, -55.87 75.57, 9.89 in-in-out SNCiio in-out ActLoopNT-in 2.9479 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 50.15, 72.02 APE9-dihe-in -112.79, 133.67 APE8-dihe-in -76.3, 73.19 APE8-rot-na 32.11 APE67-dihe-in -65.46, -14.43 -51.92, -39.05 APE12-dist-na 13.0467 APE11-dist-na 10.3491 APE10-dist-na 9.7612 APE9-dist-in 6.7989 None None None XRAY 1.98 0.199 0.243 A 274.0 262.0 11 31 31 0 [[370, 628]] 1.0 4dfl TYR_SYK_HUMAN TYR 4.4e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4YJQA P43405 364 633 635.0 4DK:701 Type1 Inactive DFGin 6.736 15.804 BLAminus -134.82, -177.19 61.29, 79.22 -100.06, 24.96 286.87, 77.55 -63.45, -29.36 in-out in 8.7579 Saltbr-out 4.8949 HRD-in -81.67, -53.67 71.29, 13.22 out-in-in SNCoii in-in ActLoopNT-in 2.9096 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.36, 108.33 APE9-dihe-in -126.44, 157.88 APE8-dihe-in -80.8, 70.11 APE8-rot-na 32.3 APE67-dihe-in -67.03, -13.75 -58.2, -31.61 APE12-dist-na 13.8615 APE11-dist-na 10.9307 APE10-dist-na 11.3078 APE9-dist-in 6.8938 None PTR525,PTR526 PTR525,PTR526 XRAY 1.34 0.162 0.183 A 281.0 266.0 4 31 31 0 [[370, 628]] 1.0 4yjq TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4YJRA P43405 364 633 635.0 4DJ:701 Type1 Inactive DFGin 6.6242 15.8872 BLAminus -132.72, -177.45 60.79, 79.89 -101.88, 24.11 286.03, 77.25 -63.73, -27.17 in-out in 8.7801 Saltbr-out 4.8064 HRD-in -81.52, -53.74 71.69, 12.94 out-in-in SNCoii in-in ActLoopNT-in 2.9278 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.41, 106.79 APE9-dihe-in -125.28, 158.73 APE8-dihe-in -81.3, 69.56 APE8-rot-na 32.68 APE67-dihe-in -66.27, -14.56 -57.04, -32.84 APE12-dist-na 13.842 APE11-dist-na 10.8871 APE10-dist-na 11.2377 APE9-dist-in 6.8596 None PTR525,PTR526 PTR525,PTR526 XRAY 1.32 0.157 0.18 A 281.0 265.0 5 31 31 0 [[370, 628]] 1.0 4yjr TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4YJTA P43405 364 633 635.0 4DQ:702 Type1 Inactive DFGin 7.0639 15.5817 BLAminus -131.45, -174.52 58.96, 73.99 -96.84, 26.0 284.85, 76.07 -63.21, -26.17 in-out in 8.6666 Saltbr-out 3.8109 HRD-in -83.12, -51.93 70.87, 9.98 out-in-in SNCoii in-in ActLoopNT-in 2.8931 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.18, 103.7 APE9-dihe-in -124.22, 158.86 APE8-dihe-in -80.04, 67.83 APE8-rot-na 30.81 APE67-dihe-in -66.36, -14.14 -52.34, -34.06 APE12-dist-na 14.1006 APE11-dist-na 10.8881 APE10-dist-na 11.1136 APE9-dist-in 6.8625 None PTR525,PTR526 PTR525,PTR526 XRAY 1.52 0.176 0.208 A 281.0 270.0 0 31 31 0 [[370, 628]] 1.0 4yjt TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4YJUA P43405 364 633 635.0 4DO:701 Type1 Inactive DFGin 7.1075 15.3802 BLAminus -134.61, -176.9 55.67, 76.17 -94.03, 20.15 284.44, 74.82 -57.56, -25.54 in-out in 8.5742 Saltbr-out 3.7569 HRD-in -78.76, -50.17 71.23, 5.94 out-in-in SNCoii in-in ActLoopNT-in 2.8608 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.06, 116.81 APE9-dihe-in -121.69, 162.72 APE8-dihe-in -76.87, 70.03 APE8-rot-na 31.7 APE67-dihe-in -64.01, -12.06 -45.6, -41.35 APE12-dist-na 999.0 APE11-dist-na 11.4211 APE10-dist-na 11.9034 APE9-dist-in 6.8276 None PTR525,PTR526 PTR525,PTR526 XRAY 1.67 0.168 0.201 A 281.0 267.0 3 31 28 3 [[370, 628]] 1.0 4yju TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4YJVA P43405 364 633 635.0 4DT:701 Type1 Inactive DFGin 7.0581 15.5393 BLAminus -132.12, -177.62 58.9, 78.21 -97.23, 24.66 284.8, 77.05 -61.21, -27.61 in-out in 8.6007 Saltbr-out 4.9613 HRD-in -80.51, -52.41 71.92, 9.69 out-in-in SNCoii in-in ActLoopNT-in 2.9031 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.0, 101.75 APE9-dihe-in -120.35, 161.01 APE8-dihe-in -81.1, 68.03 APE8-rot-na 32.46 APE67-dihe-in -66.69, -14.4 -54.32, -33.4 APE12-dist-na 13.9186 APE11-dist-na 10.7998 APE10-dist-na 11.1557 APE9-dist-in 6.8381 None PTR525,PTR526 PTR525,PTR526 XRAY 1.652 0.177 0.222 A 281.0 265.0 5 31 31 0 [[370, 628]] 1.0 4yjv TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4RSSA P43405 364 634 635.0 4MG:701 Type1 Inactive DFGin 6.3619 14.3745 BLAminus -125.51, 178.89 70.7, 70.71 -93.1, 15.53 292.82, 95.43 -58.12, -23.53 in-in in 7.9804 Saltbr-in 2.6475 HRD-in -80.43, -50.69 72.79, 4.21 in-in-out SNCiio in-out ActLoopNT-in 2.9832 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -83.33, -31.98 APE9-dihe-out -62.19, -39.48 APE8-dihe-out -88.75, -5.81 APE8-rot-na 36.86 APE67-dihe-in -61.38, -18.45 -51.57, -40.88 APE12-dist-na 11.1951 APE11-dist-na 13.649 APE10-dist-na 16.6325 APE9-dist-out 10.4074 None None None XRAY 1.83 0.214 0.249 A 290.0 269.0 2 31 31 0 [[370, 628]] 1.0 4rss TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4XG3A P43405 363 634 635.0 X3G:701 Type1 Inactive DFGin 6.561 14.2694 BLAminus -123.77, -176.77 60.27, 75.02 -93.24, 14.93 290.25, 93.45 -52.4, -30.37 in-out in 7.8828 Saltbr-out 4.3726 HRD-in -78.91, -49.84 68.75, 12.99 out-in-in SNCoii in-in ActLoopNT-in 2.8119 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.51, 96.9 APE9-dihe-in -112.53, 139.55 APE8-dihe-in -74.31, 78.49 APE8-rot-na 32.23 APE67-dihe-in -68.63, -15.73 -57.45, -34.9 APE12-dist-na 14.073 APE11-dist-na 11.0053 APE10-dist-na 10.9134 APE9-dist-in 7.1563 None None None XRAY 2.3 0.199 0.226 A 290.0 262.0 10 31 31 0 [[370, 628]] 1.0 4xg3 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4XG7A P43405 364 635 635.0 X7G:60701 Type1 Inactive DFGin 6.4465 14.3234 BLAminus -121.7, -179.92 65.73, 76.06 -96.8, 16.58 293.04, 92.3 -59.19, -26.5 in-in in 7.7856 Saltbr-in 2.689 HRD-in -75.48, -50.53 70.33, 10.44 in-in-out SNCiio in-out ActLoopNT-in 2.9192 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -77.68, -30.64 APE9-dihe-out -62.97, -34.6 APE8-dihe-out -91.68, -6.53 APE8-rot-na 34.14 APE67-dihe-in -64.14, -15.96 -52.05, -39.51 APE12-dist-na 11.1281 APE11-dist-na 13.4773 APE10-dist-na 16.5682 APE9-dist-out 10.3334 None None None XRAY 1.76 0.226 0.242 A 290.0 265.0 7 31 31 0 [[370, 628]] 1.0 4xg7 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4XG8A P43405 366 635 635.0 X8G:700 Type1 Inactive DFGin 6.3914 14.632 BLAminus -120.1, -177.66 66.71, 68.41 -88.21, 14.67 295.9, 86.73 -47.78, -34.81 in-out in 8.2587 Saltbr-out 5.0054 HRD-in -67.74, -56.67 79.0, 1.4 out-in-none SNCoin in-none ActLoopNT-in 2.8079 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 10.07 APE8-rot-na 35.22 APE67-dihe-in -73.7, -4.5 -52.82, -36.93 APE12-dist-na 11.6364 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.249 0.275 A 290.0 258.0 12 31 28 3 [[370, 628]] 1.0 4xg8 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4I0TA P43405 363 635 635.0 1B6:60701 Type1 Inactive DFGin 6.4477 14.2754 BLAminus -133.28, -166.54 54.17, 83.04 -99.17, 23.72 289.92, 92.88 -54.78, -30.8 in-in in 8.4819 Saltbr-in 2.757 HRD-in -78.62, -52.01 75.91, 3.75 in-in-out SNCiio in-out ActLoopNT-in 3.0051 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.47 APE8-dihe-in -63.58, 54.66 APE8-rot-na 27.19 APE67-dihe-in -65.32, -17.31 -39.09, -36.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.5617 None None None XRAY 1.7 0.236 0.268 A 291.0 262.0 11 31 26 5 [[370, 628]] 1.0 4i0t TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 3EMGA P43405 365 631 635.0 685:685 Type1 Inactive DFGin 6.4238 14.4354 BLAminus -130.99, -164.55 52.75, 65.2 -80.56, 24.97 299.65, 78.19 -64.0, -22.78 in-out in 8.1476 Saltbr-out 3.9691 HRD-in -79.71, -50.4 83.15, -12.3 out-in-none SNCoin in-none ActLoopNT-in 3.0609 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -116.55 APE9-dihe-in -116.09, 161.75 APE8-dihe-in -79.75, 74.02 APE8-rot-na 34.39 APE67-dihe-in -47.92, -26.61 -60.2, -39.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.8953 APE9-dist-in 7.2889 None None None XRAY 2.6 0.2 0.222 A 291.0 255.0 12 31 27 4 [[370, 628]] 1.0 3emg TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4FL3A P43405 9 635 635.0 ANP:701 ATPlike Inactive DFGin 5.2707 12.4112 BLBplus -116.27, 169.06 58.02, 22.77 -60.26, 128.95 39.87, 90.8 70.36, 3.28 out-out out 13.3472 Saltbr-out 12.957 HRD-in -71.66, -54.51 80.39, -19.8 out-out-none SNCoon out-none ActLoopNT-out 7.0299 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 2.25 APE8-rot-na 29.04 APE67-dihe-in -63.72, -20.72 -59.66, -31.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y348F,Y352F None None XRAY 1.9 0.18 0.208 A 635.0 538.0 13 31 18 13 [[370, 628]] 1.0 4fl3 TYR_SYK_HUMAN TYR 5.1e-89 304.2 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4FL2A P43405 9 635 635.0 ANP:702 ATPlike Inactive DFGin 5.4285 12.3278 BLBplus -115.2, 163.41 55.5, 31.26 -66.72, 128.2 35.56, 90.39 65.72, 13.6 out-out out 13.4906 Saltbr-out 13.2027 HRD-in -70.05, -49.77 75.03, -15.27 out-out-out SNCooo out-out ActLoopNT-out 7.1942 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.16, 144.55 APE9-dihe-in -104.91, 94.8 APE8-dihe-out -50.62, -30.17 APE8-rot-na 333.32 APE67-dihe-in -61.99, -18.29 -62.08, -21.97 APE12-dist-na 15.5558 APE11-dist-na 19.2065 APE10-dist-na 15.7365 APE9-dist-out 11.5275 None None None XRAY 2.19 0.184 0.228 A 636.0 555.0 0 31 31 0 [[370, 628]] 1.0 4fl2 TYR_SYK_HUMAN TYR 5.1e-89 304.2 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 3TUCA P43405 358 633 635.0 FPW:999 Type1.5_Front Inactive DFGin 6.5557 15.0193 BLBplus -114.33, 165.27 53.65, 40.82 -73.1, 146.31 90.45, 83.64 -43.15, -55.01 out-out out 11.4709 Saltbr-out 7.0679 HRD-in -66.05, -58.66 86.11, -25.8 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.49 APE8-rot-na 24.54 APE67-dihe-in -67.39, -16.05 -47.1, -39.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.216 0.285 A 299.0 257.0 19 31 12 19 [[370, 628]] 1.0 3tuc TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 3TUBA P43405 362 633 635.0 FPU:999 Type2 Inactive DFGout 13.74 9.6702 BBAminus -126.08, 171.13 -141.46, 68.74 -40.79, -49.16 289.47, 103.31 -92.66, 19.79 in-out in 8.3161 Saltbr-out 3.6672 HRD-in -62.48, -58.18 81.87, -14.31 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 55.79 APE8-rot-na 29.91 APE67-dihe-in -67.44, -14.12 -48.38, -36.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.23 0.182 0.232 A 293.0 253.0 19 31 12 19 [[370, 628]] 1.0 3tub TYR_SYK_HUMAN TYR 5.7e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 3TUDA P43405 363 635 635.0 FPX:60001 Type2 Inactive DFGout 15.3086 10.8657 None -123.06, 178.93 -154.97, 96.56 -80.58, 999.0 302.91, 174.18 999.0, 999.0 in-in in 8.7502 Saltbr-in 2.7565 HRD-in -65.87, -59.08 79.62, -13.62 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -60.05, 129.63 APE9-dihe-in -111.2, 153.71 APE8-dihe-in -83.04, 71.46 APE8-rot-na 31.48 APE67-dihe-in -66.5, -12.19 -53.72, -36.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.652 None None None XRAY 2.33 0.198 0.263 A 299.0 255.0 18 31 13 18 [[370, 628]] 1.0 3tud TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4XG2A P43405 364 635 635.0 No_ligand No_ligand None DFGin 6.5597 14.743 BLAminus -130.24, -178.99 62.72, 77.6 -96.14, 15.75 290.58, 78.21 -62.22, -24.62 in-in in 8.1887 Saltbr-in 2.79 HRD-in -76.73, -52.8 72.67, 7.33 in-in-none SNCiin in-none ActLoopNT-in 2.8566 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 129.75 APE9-dihe-in -121.46, 135.12 APE8-dihe-in -76.71, 74.12 APE8-rot-na 35.22 APE67-dihe-in -65.91, -17.02 -54.02, -32.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.9026 APE9-dist-in 7.0565 None None None XRAY 2.21 0.204 0.227 A 290.0 258.0 14 31 27 4 [[370, 628]] 1.0 4xg2 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 6HM7A P43405 363 633 635.0 GDH:701 Type1 None DFGin 6.5526 14.5265 BLAminus -123.85, -179.77 64.31, 73.15 -92.84, 18.31 290.79, 83.99 -60.41, -28.58 in-in in 8.0331 Saltbr-in 2.9282 HRD-in -76.88, -50.91 71.45, 2.92 in-in-none SNCiin in-none ActLoopNT-in 2.9037 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 157.3 APE8-dihe-in -78.81, 69.42 APE8-rot-na 32.62 APE67-dihe-in -63.42, -18.8 -55.15, -34.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5684 None PTR525 PTR525 XRAY 1.64 0.174 0.21 A 276.0 268.0 3 31 28 3 [[370, 628]] 1.0 6hm7 TYR_SYK_HUMAN TYR 4.5e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 5LMBB P43405 364 630 635.0 6ZF:701 Type1 None DFGin 6.5417 14.2074 BLAminus -133.05, -174.7 62.98, 72.21 -97.02, 21.38 290.54, 88.36 -62.52, -32.46 in-in in 7.7365 Saltbr-in 2.5556 HRD-in -77.26, -52.74 74.6, 8.57 in-in-none SNCiin in-none ActLoopNT-in 2.872 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.43 APE8-dihe-in -80.7, 73.18 APE8-rot-na 30.16 APE67-dihe-in -64.42, -18.25 -49.18, -37.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.9476 None PTR525 PTR525 XRAY 1.95 0.178 0.228 B 277.0 262.0 5 31 26 5 [[370, 628]] 1.0 5lmb TYR_SYK_HUMAN TYR 4.6e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 8X5KA P43405 363 632 635.0 3YT:701 Type1 None DFGin 6.3819 14.6558 BLAminus -132.21, -172.26 63.3, 68.78 -95.24, 19.38 292.18, 89.98 -56.7, -30.78 in-in in 7.8942 Saltbr-in 2.95 HRD-in -71.77, -56.19 75.58, 0.61 in-in-none SNCiin in-none ActLoopNT-in 2.9476 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.95 APE8-rot-na 32.78 APE67-dihe-in -63.64, -18.99 -57.25, -32.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.192 0.244 A 280.0 264.0 6 31 26 5 [[370, 628]] 1.0 8x5k TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 6VOVA P43405 363 629 635.0 R6D:701 Type1 None DFGin 6.4909 14.5508 BLAminus -133.59, -172.02 59.62, 69.16 -89.35, 17.8 288.33, 91.38 -60.0, -27.27 in-in in 7.9938 Saltbr-in 2.6903 HRD-in -77.79, -51.77 71.65, 6.09 in-in-none SNCiin in-none ActLoopNT-in 2.9903 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.03 APE8-dihe-in -78.95, 69.83 APE8-rot-na 28.75 APE67-dihe-in -65.35, -15.72 -44.66, -41.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.1965 None None None XRAY 1.95 0.22 0.268 A 281.0 258.0 9 31 27 4 [[370, 628]] 1.0 6vov TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 8RRZA P43405 363 633 635.0 A1H2Y:701 Type1 None DFGin 6.4609 14.6821 BLAminus -127.74, -179.45 67.79, 70.28 -94.76, 22.67 287.65, 98.81 -62.91, -34.06 in-in in 7.9641 Saltbr-in 2.8975 HRD-in -78.47, -50.78 73.26, 5.22 in-in-none SNCiin in-none ActLoopNT-in 2.9387 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.18 APE8-dihe-in -75.14, 72.0 APE8-rot-na 32.71 APE67-dihe-in -61.9, -17.04 -54.99, -37.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.332 None PTR525,PTR526 PTR525,PTR526 XRAY 1.75 0.182 0.214 A 282.0 262.0 9 31 27 4 [[370, 628]] 1.0 8rrz TYR_SYK_HUMAN TYR 4.9e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 5TR6A P43405 362 635 635.0 7KG:60701 Type1 None DFGin 6.42 14.4222 BLAminus -132.48, 179.72 59.87, 74.11 -95.94, 22.5 287.39, 87.93 -67.35, -26.8 in-none in 7.9927 Saltbr-none 999.0 HRD-in -77.83, -50.78 68.92, 14.83 none-in-in SNCnii in-in ActLoopNT-in 2.9205 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.28, 93.77 APE9-dihe-in -107.16, 142.31 APE8-dihe-in -78.63, 77.12 APE8-rot-na 32.22 APE67-dihe-in -65.12, -14.48 -58.58, -35.04 APE12-dist-na 13.6817 APE11-dist-na 10.1638 APE10-dist-na 10.5072 APE9-dist-in 6.9749 None None None XRAY 1.93 0.195 0.217 A 289.0 268.0 6 31 31 0 [[370, 628]] 1.0 5tr6 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4XG3B P43405 363 633 635.0 X3G:701 Type1 None DFGin 6.3613 14.2596 BLAminus -128.52, -176.24 59.83, 77.98 -95.46, 17.98 292.06, 88.72 -55.83, -35.07 in-in in 7.7571 Saltbr-in 2.7128 HRD-in -74.45, -44.97 66.32, 3.24 in-in-none SNCiin in-none ActLoopNT-in 3.0381 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 60.87 APE9-dihe-in -106.83, 127.91 APE8-dihe-in -75.62, 80.4 APE8-rot-na 32.03 APE67-dihe-in -68.27, -18.81 -58.02, -33.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.7584 APE9-dist-in 7.1331 None None None XRAY 2.3 0.199 0.226 B 290.0 267.0 4 31 27 4 [[370, 628]] 1.0 4xg3 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4XG4A P43405 363 635 635.0 X4G:701 Type1 None DFGin 6.6332 14.4996 BLAminus -121.07, 179.74 64.97, 74.28 -96.12, 21.86 293.04, 85.88 -61.26, -26.24 in-in in 7.9365 Saltbr-in 2.6714 HRD-in -75.83, -50.72 70.19, 14.15 in-in-none SNCiin in-none ActLoopNT-in 2.9335 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 92.08 APE9-dihe-in -117.97, 139.01 APE8-dihe-in -75.6, 78.94 APE8-rot-na 30.7 APE67-dihe-in -67.4, -20.31 -55.84, -33.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.9035 APE9-dist-in 7.112 None None None XRAY 2.3 0.195 0.228 A 290.0 264.0 9 31 27 4 [[370, 628]] 1.0 4xg4 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4XG6A P43405 363 635 635.0 X6G:60701 Type1 None DFGin 6.2537 14.3137 BLAminus -118.6, -179.8 61.85, 86.51 -104.68, 19.31 297.54, 90.69 -53.97, -29.58 in-in in 7.8485 Saltbr-in 2.6754 HRD-in -72.81, -51.23 73.7, 7.07 in-in-none SNCiin in-none ActLoopNT-in 2.9076 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -1.44 APE8-rot-na 30.73 APE67-dihe-in -63.62, -23.47 -57.96, -32.34 APE12-dist-na 11.5801 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.192 0.23 A 290.0 270.0 3 31 28 3 [[370, 628]] 1.0 4xg6 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4XG8C P43405 364 629 635.0 X8G:700 Type1 None DFGin 6.3686 14.2664 BLAminus -112.98, -178.28 65.43, 72.58 -97.08, 19.7 293.26, 93.71 -69.16, -21.23 in-in in 8.0447 Saltbr-in 2.925 HRD-in -74.14, -54.5 72.61, 6.51 in-in-none SNCiin in-none ActLoopNT-in 2.7094 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 27.72 APE8-rot-na 24.07 APE67-dihe-in -75.25, -15.23 -58.44, -32.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.249 0.275 C 290.0 254.0 12 31 26 5 [[370, 628]] 1.0 4xg8 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4XG9A P43405 363 632 635.0 X9G:700 Type1 None DFGin 6.3878 14.2532 BLAminus -123.44, -179.44 57.72, 74.85 -93.27, 25.8 301.09, 93.35 -61.2, -36.75 in-in in 7.9638 Saltbr-in 2.623 HRD-in -74.42, -57.7 72.94, 15.94 in-in-none SNCiin in-none ActLoopNT-in 2.7873 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 14.65 APE8-rot-na 19.29 APE67-dihe-in -69.72, -24.67 -61.87, -28.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.91 0.21 0.241 A 290.0 259.0 11 31 25 6 [[370, 628]] 1.0 4xg9 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4XG9B P43405 363 634 635.0 X9G:700 Type1 None DFGin 6.3472 14.2163 BLAminus -128.68, -177.25 53.27, 77.68 -95.83, 18.82 297.69, 92.87 -61.29, -26.93 in-in in 7.9683 Saltbr-in 2.5033 HRD-in -72.55, -56.82 71.48, 16.81 in-in-none SNCiin in-none ActLoopNT-in 2.8334 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 14.58 APE8-rot-na 27.68 APE67-dihe-in -67.7, -23.41 -54.17, -35.6 APE12-dist-na 11.89 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.91 0.21 0.241 B 290.0 265.0 7 31 28 3 [[370, 628]] 1.0 4xg9 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 5GHVA P43405 363 635 635.0 X5G:701 Type1 None DFGin 6.5102 14.4863 BLAminus -121.34, 177.94 62.19, 88.65 -109.69, 41.48 296.98, 84.28 -77.6, -32.83 in-in in 8.1098 Saltbr-in 2.7323 HRD-in -76.16, -59.71 78.21, 9.71 in-in-none SNCiin in-none ActLoopNT-in 2.9639 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 59.75 APE9-dihe-in -134.2, 142.35 APE8-dihe-in -78.13, 86.38 APE8-rot-na 29.33 APE67-dihe-in -64.76, -25.26 -61.51, -32.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.6682 APE9-dist-in 7.3984 None None None XRAY 2.8 0.217 0.227 A 290.0 265.0 8 31 27 4 [[370, 628]] 1.0 5ghv TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 5GHVB P43405 363 635 635.0 X5G:701 Type1 None DFGin 6.495 14.3903 BLAminus -125.29, 176.55 63.13, 89.9 -112.44, 39.0 296.07, 82.84 -75.29, -45.81 in-in in 8.0744 Saltbr-in 2.7148 HRD-in -75.16, -55.76 75.92, 10.79 in-in-none SNCiin in-none ActLoopNT-in 3.0942 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 48.46 APE9-dihe-in -133.95, 133.36 APE8-dihe-in -79.51, 91.82 APE8-rot-na 28.71 APE67-dihe-in -66.71, -23.44 -67.07, -29.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.251 APE9-dist-in 7.5687 None None None XRAY 2.8 0.217 0.227 B 290.0 265.0 8 31 27 4 [[370, 628]] 1.0 5ghv TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 8XQ0B P43405 364 634 635.0 A1LV4:701 Type1 None DFGin 6.2936 14.2694 BLAminus -121.56, -165.09 54.01, 77.14 -98.56, 23.24 296.48, 92.65 -61.88, -28.43 in-in in 8.4179 Saltbr-in 2.6489 HRD-in -77.64, -48.09 70.42, 13.58 in-in-none SNCiin in-none ActLoopNT-in 2.7959 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 110.46 APE9-dihe-in -140.12, 100.43 APE8-dihe-in -73.17, 75.7 APE8-rot-na 30.62 APE67-dihe-in -68.44, -13.24 -66.75, -26.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.655 APE9-dist-in 6.8754 None None None XRAY 1.95 0.222 0.265 B 290.0 253.0 18 31 27 4 [[370, 628]] 1.0 8xq0 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 8XQ0D P43405 364 635 635.0 A1LV4:701 Type1 None DFGin 6.3141 14.39 BLAminus -120.19, -170.79 65.2, 70.98 -95.79, 24.62 295.16, 93.42 -63.39, -28.44 in-in in 8.488 Saltbr-in 2.7009 HRD-in -76.01, -49.61 70.34, 8.1 in-in-none SNCiin in-none ActLoopNT-in 2.7872 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 140.86 APE9-dihe-in -154.41, 100.57 APE8-dihe-in -72.25, 67.88 APE8-rot-na 28.73 APE67-dihe-in -63.58, -17.28 -53.94, -36.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.1642 APE9-dist-in 6.9631 None None None XRAY 1.95 0.222 0.265 D 290.0 258.0 14 31 27 4 [[370, 628]] 1.0 8xq0 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 8XQ1A P43405 364 634 635.0 A1LV6:901 Type1 None DFGin 6.3005 14.4821 BLAminus -124.74, -173.52 66.63, 71.35 -96.63, 19.35 289.84, 89.05 -66.02, -25.46 in-in in 8.2664 Saltbr-in 2.8165 HRD-in -80.15, -50.35 70.61, 8.83 in-in-none SNCiin in-none ActLoopNT-in 2.9599 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 134.1 APE9-dihe-in -110.96, 150.88 APE8-dihe-in -81.12, 69.26 APE8-rot-na 30.82 APE67-dihe-in -65.34, -12.5 -60.05, -31.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.5951 APE9-dist-in 7.0861 None None None XRAY 1.5 0.188 0.209 A 290.0 263.0 8 31 28 3 [[370, 628]] 1.0 8xq1 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 8XQ1B P43405 364 634 635.0 A1LV6:901 Type1 None DFGin 6.3063 14.4383 BLAminus -122.4, -173.86 66.54, 73.25 -99.1, 21.97 289.94, 89.92 -65.7, -26.72 in-in in 8.2054 Saltbr-in 2.8276 HRD-in -76.67, -51.02 71.1, 10.17 in-in-none SNCiin in-none ActLoopNT-in 2.9809 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 119.35 APE9-dihe-in -109.54, 149.84 APE8-dihe-in -80.64, 68.82 APE8-rot-na 32.7 APE67-dihe-in -66.82, -12.34 -64.74, -24.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.3635 APE9-dist-in 7.1118 None None None XRAY 1.5 0.188 0.209 B 290.0 263.0 8 31 28 3 [[370, 628]] 1.0 8xq1 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 8XQ2A P43405 363 634 635.0 A1LV7:802 Type1 None DFGin 6.3658 14.4252 BLAminus -126.78, -178.48 65.06, 70.63 -92.55, 21.67 293.19, 85.55 -66.06, -22.05 in-in in 8.3413 Saltbr-in 2.8288 HRD-in -77.37, -51.66 73.37, 4.48 in-in-none SNCiin in-none ActLoopNT-in 2.9034 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 83.79 APE8-rot-na 27.63 APE67-dihe-in -66.2, -13.18 -59.95, -35.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.206 0.238 A 290.0 263.0 9 31 27 4 [[370, 628]] 1.0 8xq2 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 8XQ2B P43405 364 632 635.0 A1LV7:701 Type1 None DFGin 6.4068 14.5701 BLAminus -126.32, -176.03 64.56, 73.36 -94.65, 19.7 292.4, 83.49 -62.95, -22.08 in-in in 8.2828 Saltbr-in 2.9205 HRD-in -78.79, -49.2 70.93, 7.72 in-in-none SNCiin in-none ActLoopNT-in 2.9523 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 81.5 APE9-dihe-in -124.35, 129.64 APE8-dihe-in -71.15, 79.1 APE8-rot-na 29.02 APE67-dihe-in -66.5, -10.69 -61.42, -32.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.7504 APE9-dist-in 6.8398 None None None XRAY 1.8 0.206 0.238 B 290.0 261.0 8 31 29 2 [[370, 628]] 1.0 8xq2 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 1XBBA P43405 363 635 635.0 STI:60001 Type1 None DFGin 6.6637 14.623 BLAminus -128.05, 176.75 68.38, 79.08 -100.61, 19.15 290.6, 90.35 -58.48, -28.27 in-in in 8.2357 Saltbr-in 3.0323 HRD-in -76.13, -51.62 74.69, 4.56 in-in-none SNCiin in-none ActLoopNT-in 2.8779 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 178.76 APE9-dihe-in -111.48, 137.0 APE8-dihe-in -74.08, 70.57 APE8-rot-na 29.87 APE67-dihe-in -65.65, -14.73 -52.2, -36.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.1255 APE9-dist-in 7.1998 None None None XRAY 1.57 0.191 0.221 A 291.0 264.0 9 31 27 4 [[370, 628]] 1.0 1xbb TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 3FQEA P43405 363 635 635.0 P5C:60001 Type1 None DFGin 6.2412 14.5522 BLAminus -134.09, -160.32 61.99, 71.61 -98.66, 22.24 289.6, 83.21 -60.61, -25.52 in-in in 8.2494 Saltbr-in 3.3621 HRD-in -87.09, -50.31 69.38, 7.86 in-in-none SNCiin in-none ActLoopNT-in 2.9525 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 126.45 APE9-dihe-in -122.15, 142.06 APE8-dihe-in -70.06, 69.94 APE8-rot-na 27.41 APE67-dihe-in -70.93, -8.12 -53.23, -38.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.2122 APE9-dist-in 7.0719 None None None XRAY 2.5 0.203 0.253 A 291.0 265.0 8 31 28 3 [[370, 628]] 1.0 3fqe TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 3FQHB P43405 363 633 635.0 057:2 Type1 None DFGin 6.5124 14.384 BLAminus -135.61, -177.0 61.05, 83.05 -100.81, 28.19 289.97, 93.91 -68.13, -27.21 in-in in 7.9505 Saltbr-in 2.9286 HRD-in -70.78, -57.98 73.35, 4.27 in-in-none SNCiin in-none ActLoopNT-in 2.9456 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 140.44 APE9-dihe-in -122.67, 149.45 APE8-dihe-in -71.04, 64.02 APE8-rot-na 27.55 APE67-dihe-in -70.95, -10.14 -42.56, -38.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.9315 APE9-dist-in 7.0578 None None None XRAY 2.26 0.216 0.259 B 291.0 258.0 13 31 27 4 [[370, 628]] 1.0 3fqh TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 3FQSA P43405 363 635 635.0 585:60001 Type1 None DFGin 6.6713 15.1191 BLAminus -130.1, -168.06 51.07, 81.04 -99.05, 21.72 287.94, 89.19 -65.06, -25.56 in-in in 8.2508 Saltbr-in 2.8899 HRD-in -73.57, -53.38 73.0, 6.23 in-in-none SNCiin in-none ActLoopNT-in 2.927 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 124.94 APE9-dihe-in -106.74, 133.78 APE8-dihe-in -71.17, 66.53 APE8-rot-na 27.84 APE67-dihe-in -63.27, -16.28 -46.11, -40.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.7157 APE9-dist-in 7.4905 None None None XRAY 2.1 0.218 0.253 A 291.0 264.0 9 31 27 4 [[370, 628]] 1.0 3fqs TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4FYNA P43405 363 635 635.0 0VE:60701 Type1 None DFGin 6.3219 14.5516 BLAminus -125.05, -173.65 56.58, 84.17 -104.44, 22.0 295.83, 84.03 -64.28, -16.7 in-in in 8.1681 Saltbr-in 2.7467 HRD-in -77.65, -54.89 74.1, 7.86 in-in-none SNCiin in-none ActLoopNT-in 2.9237 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 150.74 APE9-dihe-in -119.38, 130.75 APE8-dihe-in -71.21, 75.44 APE8-rot-na 25.91 APE67-dihe-in -62.88, -14.32 -62.84, -38.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.7508 APE9-dist-in 7.3399 None None None XRAY 2.318 0.228 0.269 A 291.0 263.0 10 31 27 4 [[370, 628]] 1.0 4fyn TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4FYOA P43405 363 635 635.0 0VF:60701 Type1 None DFGin 6.5272 14.6759 BLAminus -132.65, -177.95 62.23, 72.42 -93.99, 21.12 289.45, 90.18 -61.07, -25.58 in-in in 7.7502 Saltbr-in 2.757 HRD-in -74.26, -50.97 72.76, 4.05 in-in-none SNCiin in-none ActLoopNT-in 2.9524 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 140.05 APE9-dihe-in -108.11, 144.2 APE8-dihe-in -76.07, 73.27 APE8-rot-na 27.85 APE67-dihe-in -65.29, -14.44 -52.41, -38.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.9467 APE9-dist-in 7.3079 None None None XRAY 1.4 0.22 0.24 A 291.0 263.0 10 31 27 4 [[370, 628]] 1.0 4fyo TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4FZ6A P43405 363 635 635.0 0VG:60701 Type1 None DFGin 6.3168 14.6915 BLAminus -133.65, -169.74 58.51, 78.15 -100.44, 26.78 291.45, 90.91 -64.04, -31.24 in-in in 8.4426 Saltbr-in 3.0064 HRD-in -75.46, -52.97 71.45, 4.73 in-in-none SNCiin in-none ActLoopNT-in 2.9013 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 139.2 APE9-dihe-in -115.79, 143.14 APE8-dihe-in -76.09, 69.74 APE8-rot-na 28.85 APE67-dihe-in -66.47, -14.43 -53.02, -38.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.4665 APE9-dist-in 7.234 None None None XRAY 1.85 0.23 0.253 A 291.0 262.0 11 31 27 4 [[370, 628]] 1.0 4fz6 TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4FZ7A P43405 363 635 635.0 0VH:60701 Type1 None DFGin 6.4003 14.4126 BLAminus -130.24, -170.94 63.54, 68.16 -91.78, 16.19 289.77, 87.77 -59.49, -25.0 in-in in 8.2193 Saltbr-in 2.9497 HRD-in -74.99, -52.16 71.67, 6.11 in-in-none SNCiin in-none ActLoopNT-in 2.8772 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 93.82 APE9-dihe-in -107.75, 152.66 APE8-dihe-in -78.57, 65.92 APE8-rot-na 31.11 APE67-dihe-in -66.21, -17.27 -45.73, -35.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.6065 APE9-dist-in 6.9009 None None None XRAY 1.75 0.202 0.25 A 291.0 261.0 12 31 27 4 [[370, 628]] 1.0 4fz7 TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4I0RA P43405 363 635 635.0 1B4:60701 Type1 None DFGin 6.3034 14.4722 BLAminus -120.7, -175.74 66.13, 76.03 -99.52, 27.66 293.49, 90.9 -68.19, -27.87 in-in in 8.0785 Saltbr-in 2.7945 HRD-in -77.52, -55.13 72.71, 3.63 in-in-none SNCiin in-none ActLoopNT-in 2.8563 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 132.26 APE9-dihe-in -103.47, 139.74 APE8-dihe-in -70.94, 75.19 APE8-rot-na 28.76 APE67-dihe-in -61.34, -17.47 -59.11, -38.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.7267 APE9-dist-in 7.1578 None None None XRAY 2.1 0.237 0.272 A 291.0 260.0 13 31 27 4 [[370, 628]] 1.0 4i0r TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4I0SA P43405 363 635 635.0 1B5:60701 Type1 None DFGin 6.3483 14.3184 BLAminus -129.27, -175.27 55.43, 83.6 -98.08, 24.19 289.58, 86.12 -61.12, -27.32 in-in in 8.0335 Saltbr-in 2.5894 HRD-in -71.15, -52.29 70.43, 7.1 in-in-none SNCiin in-none ActLoopNT-in 2.9258 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 126.23 APE9-dihe-in -113.12, 145.51 APE8-dihe-in -74.21, 66.56 APE8-rot-na 27.25 APE67-dihe-in -64.4, -15.49 -48.66, -38.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.6732 APE9-dist-in 7.2386 None None None XRAY 1.98 0.218 0.236 A 291.0 263.0 10 31 27 4 [[370, 628]] 1.0 4i0s TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4PUZA P43405 363 633 635.0 CG9:701 Type1 None DFGin 6.3668 14.2903 BLAminus -136.54, -176.83 63.98, 77.0 -97.69, 30.02 296.24, 87.49 -65.1, -31.87 in-in in 7.9295 Saltbr-in 2.8225 HRD-in -73.68, -57.13 77.44, 4.88 in-in-none SNCiin in-none ActLoopNT-in 2.806 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 106.61 APE9-dihe-in -123.49, 140.78 APE8-dihe-in -68.55, 53.64 APE8-rot-na 28.04 APE67-dihe-in -67.84, -11.38 -28.81, -44.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.9145 APE9-dist-in 7.237 None None None XRAY 2.085 0.213 0.261 A 291.0 263.0 8 31 28 3 [[370, 628]] 1.0 4puz TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4PUZB P43405 363 635 635.0 CG9:701 Type1 None DFGin 6.3028 14.2734 BLAminus -130.49, 178.11 63.06, 88.54 -109.96, 27.3 298.33, 92.7 -70.91, -20.76 in-in in 7.8147 Saltbr-in 2.9053 HRD-in -68.83, -56.51 73.59, 10.98 in-in-none SNCiin in-none ActLoopNT-in 2.6785 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 100.98 APE9-dihe-in -104.75, 136.54 APE8-dihe-in -73.52, 61.27 APE8-rot-na 28.37 APE67-dihe-in -69.59, -18.44 -38.04, -42.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.4136 APE9-dist-in 6.9757 None None None XRAY 2.085 0.213 0.261 B 291.0 265.0 8 31 28 3 [[370, 628]] 1.0 4puz TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 5T68A P43405 363 635 635.0 77V:60701 Type1 None DFGin 6.3993 14.2326 BLAminus -118.2, -175.03 55.02, 90.22 -105.11, 31.93 294.35, 102.52 -80.93, -22.27 in-in in 7.8644 Saltbr-in 2.7665 HRD-in -79.38, -47.76 69.54, -3.58 in-in-none SNCiin in-none ActLoopNT-in 3.07 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -53.8 APE9-dihe-in -121.95, 75.31 APE8-dihe-in -77.88, 51.45 APE8-rot-na 19.76 APE67-dihe-in -78.2, -26.54 -39.48, -21.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.2909 APE9-dist-in 7.5867 None None None XRAY 2.93 0.188 0.281 A 291.0 264.0 9 31 27 4 [[370, 628]] 1.0 5t68 TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 5T68B P43405 363 635 635.0 77V:60701 Type1 None DFGin 6.3354 14.5494 BLAminus -125.81, -173.18 53.62, 72.36 -90.46, 31.38 289.78, 97.36 -69.64, -47.12 in-in in 7.8586 Saltbr-in 2.7952 HRD-in -56.8, -40.48 64.3, -8.06 in-in-none SNCiin in-none ActLoopNT-in 2.9962 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -66.53 APE9-dihe-in -122.76, 73.0 APE8-dihe-in -76.02, 70.05 APE8-rot-na 29.83 APE67-dihe-in -58.48, -8.81 -36.73, -49.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.2436 APE9-dist-in 6.8603 None None None XRAY 2.93 0.188 0.281 B 291.0 264.0 9 31 27 4 [[370, 628]] 1.0 5t68 TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 5Y5UB P43405 363 629 635.0 8OU:701 Type1 None DFGin 6.3221 13.9991 BLAminus -136.83, 172.48 60.12, 69.06 -76.3, 17.06 301.14, 79.7 -45.71, -46.86 in-in in 7.647 Saltbr-in 2.7979 HRD-in -72.89, -51.34 74.65, -2.0 in-in-none SNCiin in-none ActLoopNT-in 2.8215 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 45.91 APE8-rot-na 27.44 APE67-dihe-in -59.42, -23.8 -55.69, -38.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.14 0.239 0.26 B 293.0 257.0 10 31 25 6 [[370, 628]] 1.0 5y5u TYR_SYK_HUMAN TYR 5.7e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 8WYWA P43405 364 633 635.0 XFB:701 Type1 None DFGin 6.2371 14.4668 BLAminus -132.59, -164.71 66.23, 68.08 -96.88, 23.52 293.79, 90.86 -58.6, -30.92 in-in in 8.0458 Saltbr-in 2.7999 HRD-in -78.12, -54.08 75.86, 6.55 in-in-none SNCiin in-none ActLoopNT-in 2.953 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 61.34 APE8-rot-na 31.52 APE67-dihe-in -65.01, -13.06 -58.71, -34.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.202 0.242 A 293.0 264.0 6 31 25 6 [[370, 628]] 1.0 8wyw TYR_SYK_HUMAN TYR 5.7e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 8WYWB P43405 365 633 635.0 XFB:701 Type1 None DFGin 6.298 14.4316 BLAminus -136.18, -166.23 64.92, 68.41 -94.85, 24.26 293.81, 88.05 -62.54, -27.54 in-in in 8.0999 Saltbr-in 2.7616 HRD-in -75.21, -53.42 72.9, 5.68 in-in-none SNCiin in-none ActLoopNT-in 2.9696 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 56.28 APE8-rot-na 30.56 APE67-dihe-in -70.56, -10.12 -50.08, -35.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.202 0.242 B 293.0 263.0 6 31 25 6 [[370, 628]] 1.0 8wyw TYR_SYK_HUMAN TYR 5.7e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 3VF8A P43405 363 635 635.0 0JE:701 Type1 None DFGin 6.3028 14.2743 BLAminus -127.47, -170.59 55.16, 83.49 -101.53, 21.98 288.96, 89.41 -58.75, -35.76 in-none in 8.0426 Saltbr-none 999.0 HRD-in -73.27, -51.41 67.21, 6.99 none-in-in SNCnii in-in ActLoopNT-in 2.9847 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.14, 90.57 APE9-dihe-in -105.62, 138.03 APE8-dihe-in -81.27, 73.81 APE8-rot-na 26.23 APE67-dihe-in -66.47, -16.98 -51.38, -34.52 APE12-dist-na 13.2571 APE11-dist-na 10.0917 APE10-dist-na 10.0065 APE9-dist-in 6.7963 None None None XRAY 2.08 0.217 0.241 A 299.0 265.0 8 31 31 0 [[370, 628]] 1.0 3vf8 TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 3VF9A P43405 364 635 635.0 477:701 Type1 None DFGin 6.3963 14.6399 BLAminus -128.07, -174.94 57.37, 81.54 -100.98, 31.05 291.59, 91.29 -68.94, -37.68 in-none in 7.996 Saltbr-none 999.0 HRD-in -72.91, -49.87 65.85, 9.08 none-in-in SNCnii in-in ActLoopNT-in 3.0228 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.57, 94.78 APE9-dihe-in -116.96, 141.01 APE8-dihe-in -83.94, 81.53 APE8-rot-na 20.28 APE67-dihe-in -58.58, -19.75 -44.92, -48.84 APE12-dist-na 13.2066 APE11-dist-na 10.5082 APE10-dist-na 9.8773 APE9-dist-in 6.6964 None None None XRAY 2.3 0.255 0.267 A 299.0 265.0 7 31 31 0 [[370, 628]] 1.0 3vf9 TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 6SSBA P43405 363 635 635.0 LUE:60701 Type1 None DFGin 6.5917 14.4675 BLAminus -122.14, -172.72 60.63, 82.61 -104.23, 21.05 289.2, 91.73 -65.13, -29.21 in-in in 8.3222 Saltbr-in 2.9383 HRD-in -79.93, -48.97 63.18, 12.69 in-in-none SNCiin in-none ActLoopNT-in 2.8303 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 141.28 APE9-dihe-in -123.27, 130.6 APE8-dihe-in -78.29, 70.91 APE8-rot-na 28.49 APE67-dihe-in -60.55, -20.65 -51.68, -36.02 APE12-dist-na 13.3546 APE11-dist-na 999.0 APE10-dist-na 11.696 APE9-dist-in 7.5985 None None None XRAY 2.08 0.198 0.225 A 299.0 265.0 8 31 30 1 [[370, 628]] 1.0 6ssb TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 6ZCQA P43405 363 635 635.0 QFB:60701 Type1 None DFGin 6.2843 14.2005 BLAminus -124.06, -169.43 66.04, 72.78 -96.7, 17.81 287.27, 83.52 -60.89, -32.14 in-in in 7.9918 Saltbr-in 2.9869 HRD-in -74.82, -45.46 62.85, 5.49 in-in-none SNCiin in-none ActLoopNT-in 2.7856 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 48.57 APE9-dihe-in -117.91, 130.07 APE8-dihe-in -75.75, 81.23 APE8-rot-na 23.59 APE67-dihe-in -67.53, -16.63 -56.17, -31.85 APE12-dist-na 13.3427 APE11-dist-na 999.0 APE10-dist-na 10.6629 APE9-dist-in 7.588 None None None XRAY 2.32 0.191 0.244 A 299.0 265.0 8 31 30 1 [[370, 628]] 1.0 6zcq TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 6ZCRA P43405 363 635 635.0 5JG:60701 Type1 None DFGin 6.6911 14.6157 BLAminus -131.25, -174.99 58.52, 82.29 -98.4, 23.45 287.56, 81.54 -60.43, -25.78 in-in in 8.0047 Saltbr-in 2.9213 HRD-in -78.76, -53.73 70.25, 7.39 in-in-none SNCiin in-none ActLoopNT-in 2.8035 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.61 APE8-dihe-in -81.67, 70.3 APE8-rot-na 33.8 APE67-dihe-in -65.02, -14.57 -49.04, -40.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.7148 None None None XRAY 1.73 0.189 0.218 A 299.0 264.0 9 31 27 4 [[370, 628]] 1.0 6zcr TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 6ZCSA P43405 363 635 635.0 QFE:60701 Type1 None DFGin 6.4231 14.5156 BLAminus -134.38, -165.15 61.58, 75.97 -101.01, 19.73 286.51, 84.39 -60.24, -29.14 in-in in 8.0858 Saltbr-in 2.9668 HRD-in -75.9, -52.9 70.28, 10.24 in-in-none SNCiin in-none ActLoopNT-in 2.9526 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 129.22 APE9-dihe-in -113.36, 141.08 APE8-dihe-in -78.2, 72.25 APE8-rot-na 29.63 APE67-dihe-in -66.52, -13.86 -50.21, -39.33 APE12-dist-na 13.3749 APE11-dist-na 999.0 APE10-dist-na 11.3069 APE9-dist-in 7.0916 None None None XRAY 1.47 0.191 0.208 A 299.0 267.0 6 31 30 1 [[370, 628]] 1.0 6zcs TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 6ZCUA P43405 363 635 635.0 5JG:60701 Type1 None DFGin 6.6911 14.6157 BLAminus -131.25, -174.99 58.52, 82.29 -98.4, 23.45 287.56, 81.54 -60.43, -25.78 in-in in 8.0047 Saltbr-in 2.9213 HRD-in -78.76, -53.73 70.25, 7.39 in-in-none SNCiin in-none ActLoopNT-in 2.8035 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.61 APE8-dihe-in -81.67, 70.3 APE8-rot-na 33.8 APE67-dihe-in -65.02, -14.57 -49.04, -40.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.7148 None None None XRAY 1.73 0.189 0.218 A 299.0 264.0 9 31 27 4 [[370, 628]] 1.0 6zcu TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 6ZCXA P43405 363 635 635.0 QFQ:60701 Type1 None DFGin 6.3945 14.216 BLAminus -127.67, -173.55 62.06, 69.93 -92.28, 16.27 287.89, 90.74 -57.86, -30.2 in-in in 7.9808 Saltbr-in 2.76 HRD-in -77.57, -48.61 68.8, 7.96 in-in-none SNCiin in-none ActLoopNT-in 2.8651 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 153.3 APE9-dihe-in -109.71, 136.91 APE8-dihe-in -79.72, 69.78 APE8-rot-na 28.01 APE67-dihe-in -63.91, -15.97 -45.91, -39.08 APE12-dist-na 13.3538 APE11-dist-na 999.0 APE10-dist-na 11.597 APE9-dist-in 7.1674 None None None XRAY 1.66 0.191 0.229 A 299.0 263.0 10 31 30 1 [[370, 628]] 1.0 6zcx TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 6ZCYA P43405 363 635 635.0 QF8:60701 Type1 None DFGin 6.3873 14.1917 BLAminus -129.73, -170.79 60.52, 70.48 -91.88, 15.3 287.22, 87.41 -58.42, -30.07 in-in in 7.9303 Saltbr-in 2.7679 HRD-in -74.39, -48.85 68.77, 6.76 in-in-none SNCiin in-none ActLoopNT-in 2.961 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 129.7 APE9-dihe-in -121.42, 129.82 APE8-dihe-in -80.2, 74.63 APE8-rot-na 27.78 APE67-dihe-in -63.99, -16.94 -49.51, -37.22 APE12-dist-na 13.9777 APE11-dist-na 999.0 APE10-dist-na 10.3668 APE9-dist-in 7.055 None None None XRAY 1.81 0.19 0.223 A 299.0 263.0 10 31 30 1 [[370, 628]] 1.0 6zcy TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 8BI2A P43405 363 635 635.0 QR7:60701 Type1 None DFGin 6.3914 14.3495 BLAminus -125.08, -171.04 64.92, 73.8 -98.47, 21.21 291.51, 90.98 -64.58, -29.05 in-in in 8.1756 Saltbr-in 2.8892 HRD-in -78.14, -51.69 70.22, 11.64 in-in-none SNCiin in-none ActLoopNT-in 2.9048 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 81.28 APE9-dihe-in -115.01, 139.63 APE8-dihe-in -80.07, 71.09 APE8-rot-na 29.24 APE67-dihe-in -64.38, -13.13 -46.76, -40.63 APE12-dist-na 12.7009 APE11-dist-na 999.0 APE10-dist-na 9.9378 APE9-dist-in 7.0069 None None None XRAY 1.508 0.205 0.235 A 299.0 264.0 9 31 30 1 [[370, 628]] 1.0 8bi2 TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 5CXZA P43405 363 635 635.0 55U:60703 Type1 None DFGin 6.5387 14.3651 BLAminus -122.74, -171.85 60.83, 74.48 -94.07, 15.61 289.21, 94.41 -56.97, -30.72 in-in in 7.9532 Saltbr-in 2.8179 HRD-in -72.21, -54.6 71.31, 11.0 in-in-none SNCiin in-none ActLoopNT-in 2.9944 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 104.14 APE9-dihe-in -107.14, 142.58 APE8-dihe-in -80.12, 71.68 APE8-rot-na 30.9 APE67-dihe-in -65.83, -15.68 -54.56, -35.41 APE12-dist-na 13.5088 APE11-dist-na 999.0 APE10-dist-na 11.3489 APE9-dist-in 7.1319 K467T None None XRAY 1.7 0.195 0.208 A 289.0 267.0 6 31 30 1 [[370, 628]] 1.0 5cxz TYR_SYK_HUMAN TYR 3.9e-90 307.6 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK 4PX6A P43405 364 635 635.0 2X6:60701 Type1 None DFGin 6.5961 14.5568 BLAminus -133.62, -172.86 59.0, 67.69 -88.07, 18.86 287.15, 91.9 -59.4, -27.39 in-in in 7.764 Saltbr-in 2.8025 HRD-in -78.31, -51.2 71.98, 5.54 in-in-none SNCiin in-none ActLoopNT-in 2.9336 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 131.68 APE9-dihe-in -102.64, 145.76 APE8-dihe-in -78.83, 69.49 APE8-rot-na 28.48 APE67-dihe-in -64.5, -16.03 -45.05, -41.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.9576 APE9-dist-in 7.3534 K467T None None XRAY 1.6 0.176 0.202 A 291.0 261.0 11 31 27 4 [[370, 628]] 1.0 4px6 TYR_SYK_HUMAN TYR 4e-90 307.6 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK

TYR_SYK (Tyrosine-protein kinase SYK)

Total number of chains: 103
Active chains: 36
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 98 95.1% AF-P43405-K1A
DFGin BLBplus 3 2.9% 4FL2A
DFGout BBAminus 1 1.0% 3TUBA
DFGout None 1 1.0% 3TUDA

Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
SYK KSYK_HUMAN 4FL1A P43405 363 635 635.0 ANP:701 ATPlike Active DFGin 6.6692 15.0632 BLAminus -122.6, -175.53 56.16, 78.38 -92.62, 24.67 287.04, 93.75 -57.67, -38.36 in-in in 8.0588 Saltbr-in 2.6833 HRD-in -76.27, -50.57 71.77, 3.28 in-in-in SNCiii in-in ActLoopNT-in 2.9759 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.55, 85.11 APE9-dihe-in -99.28, 138.37 APE8-dihe-in -79.64, 69.72 APE8-rot-na 29.68 APE67-dihe-in -60.65, -16.95 -44.16, -41.68 APE12-dist-na 13.8161 APE11-dist-na 10.806 APE10-dist-na 10.4124 APE9-dist-in 7.1318 None None None XRAY 1.79 0.197 0.225 A 291.0 268.0 5 31 31 0 [[370, 628]] 1.0 4fl1 Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN AF-P43405-K1A P43405 362 635 635.0 No_ligand No_ligand Active DFGin 6.555 14.2826 BLAminus -139.44, 178.99 59.92, 76.86 -92.13, 11.74 288.31, 88.77 -62.73, -28.38 in-in in 8.2953 Saltbr-in 2.6504 HRD-in -79.06, -42.92 61.69, 3.61 in-in-in SNCiii in-in ActLoopNT-in 2.8958 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.91, 86.51 APE9-dihe-in -86.43, 140.76 APE8-dihe-in -76.46, 66.17 APE8-rot-na 36.18 APE67-dihe-in -68.53, -16.84 -44.81, -36.23 APE12-dist-na 14.0823 APE11-dist-na 9.8667 APE10-dist-na 10.6208 APE9-dist-in 6.9529 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 31 31 0 [[370, 628]] 1.0 AF-P43405-K1 Homo sapiens TYR_SYK_HUMAN TYR 4.4e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN AF-P43405-K3A P43405 362 635 635.0 No_ligand No_ligand Active DFGin 6.251 14.4217 BLAminus -144.99, -179.8 59.41, 72.04 -85.9, 11.12 288.49, 84.65 -61.31, -25.31 in-in in 8.4775 Saltbr-in 2.7021 HRD-in -76.05, -44.23 63.83, -5.43 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.2, 83.8 APE9-dihe-in -94.84, 151.9 APE8-dihe-in -77.3, 64.33 APE8-rot-na 36.0 APE67-dihe-in -67.48, -13.27 -45.03, -34.91 APE12-dist-na 14.3541 APE11-dist-na 10.3178 APE10-dist-na 11.5647 APE9-dist-in 7.1916 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 31 31 0 [[370, 628]] 1.0 AF-P43405-K3 Homo sapiens TYR_SYK_HUMAN TYR 4.4e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 1XBAA P43405 363 635 635.0 No_ligand No_ligand Active DFGin 6.2832 14.3878 BLAminus -126.49, -176.52 55.21, 85.12 -100.47, 21.0 289.26, 85.99 -66.46, -29.63 in-in in 7.9237 Saltbr-in 3.2803 HRD-in -79.13, -52.49 65.3, 12.61 in-in-in SNCiii in-in ActLoopNT-in 2.7688 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.47, 98.05 APE9-dihe-in -115.59, 139.53 APE8-dihe-in -72.13, 70.06 APE8-rot-na 26.48 APE67-dihe-in -72.34, -11.74 -55.87, -33.02 APE12-dist-na 13.3709 APE11-dist-na 9.5361 APE10-dist-na 9.8853 APE9-dist-in 6.4759 None None None XRAY 2.0 0.231 0.278 A 291.0 265.0 8 31 31 0 [[370, 628]] 1.0 1xba Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4F4PA P43405 365 635 635.0 0SB:60701 Type1 Active DFGin 6.3733 14.5391 BLAminus -124.15, 178.53 62.38, 80.95 -106.72, 25.8 293.21, 86.39 -66.32, -31.8 in-in in 8.3369 Saltbr-in 3.5473 HRD-in -76.55, -51.58 69.18, 8.78 in-in-in SNCiii in-in ActLoopNT-in 2.9954 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.78, 99.03 APE9-dihe-in -104.94, 133.88 APE8-dihe-in -73.17, 77.69 APE8-rot-na 29.01 APE67-dihe-in -66.28, -12.67 -56.63, -36.73 APE12-dist-na 13.3146 APE11-dist-na 9.5636 APE10-dist-na 10.4225 APE9-dist-in 6.8712 None None None XRAY 2.37 0.241 0.285 A 273.0 260.0 11 31 31 0 [[370, 628]] 1.0 4f4p Homo sapiens TYR_SYK_HUMAN TYR 4.3e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4DFNA P43405 363 635 635.0 0K1:60701 Type1 Active DFGin 6.4903 14.4545 BLAminus -130.15, -170.0 61.62, 83.88 -107.34, 23.58 294.6, 91.76 -72.41, -22.45 in-in in 8.746 Saltbr-in 3.1828 HRD-in -85.27, -46.79 70.7, 5.96 in-in-in SNCiii in-in ActLoopNT-in 3.006 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.4, 98.4 APE9-dihe-in -102.46, 134.32 APE8-dihe-in -74.07, 82.6 APE8-rot-na 30.43 APE67-dihe-in -65.57, -16.86 -58.25, -34.59 APE12-dist-na 13.6546 APE11-dist-na 10.7083 APE10-dist-na 11.3247 APE9-dist-in 7.3012 None None None XRAY 2.48 0.222 0.273 A 274.0 268.0 5 31 31 0 [[370, 628]] 1.0 4dfn Homo sapiens TYR_SYK_HUMAN TYR 4.4e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4PV0A P43405 363 635 635.0 CG4:60701 Type1 Active DFGin 6.4011 14.6067 BLAminus -130.2, -175.25 67.21, 78.78 -101.45, 20.11 290.66, 99.39 -65.44, -27.35 in-in in 8.4663 Saltbr-in 3.4401 HRD-in -78.38, -54.31 73.62, 9.17 in-in-in SNCiii in-in ActLoopNT-in 2.8351 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.94, 106.38 APE9-dihe-in -116.79, 139.9 APE8-dihe-in -79.38, 71.94 APE8-rot-na 33.78 APE67-dihe-in -68.26, -13.59 -53.62, -38.3 APE12-dist-na 13.1611 APE11-dist-na 9.8666 APE10-dist-na 10.488 APE9-dist-in 6.9382 None None None XRAY 2.0 0.231 0.282 A 275.0 266.0 7 31 31 0 [[370, 628]] 1.0 4pv0 Homo sapiens TYR_SYK_HUMAN TYR 4.5e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 6HM6A P43405 364 632 635.0 GDK:701 Type1 Active DFGin 6.5096 14.7161 BLAminus -135.72, 178.12 60.9, 85.59 -101.68, 17.9 294.15, 88.35 -56.95, -33.53 in-in in 8.2553 Saltbr-in 2.9855 HRD-in -76.78, -53.52 71.64, 11.57 in-in-in SNCiii in-in ActLoopNT-in 2.9174 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -60.26, 138.11 APE9-dihe-in -138.15, 72.71 APE8-dihe-in -77.49, 77.46 APE8-rot-na 32.95 APE67-dihe-in -66.81, -17.94 -54.41, -33.99 APE12-dist-na 999.0 APE11-dist-na 9.2391 APE10-dist-na 7.7529 APE9-dist-in 7.6681 None PTR525 PTR525 XRAY 2.1 0.217 0.29 A 276.0 261.0 8 31 29 2 [[370, 628]] 1.0 6hm6 Homo sapiens TYR_SYK_HUMAN TYR 4.5e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 3SRVA P43405 364 634 635.0 S19:1 Type1 Active DFGin 6.2782 14.0241 BLAminus -137.61, -172.24 65.42, 72.28 -96.27, 25.84 296.23, 89.02 -63.12, -26.69 in-in in 7.7479 Saltbr-in 2.717 HRD-in -84.44, -49.93 72.25, 5.56 in-in-in SNCiii in-in ActLoopNT-in 2.9734 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.48, 113.26 APE9-dihe-in -101.68, 153.86 APE8-dihe-in -78.64, 68.9 APE8-rot-na 34.87 APE67-dihe-in -67.25, -14.96 -56.26, -32.84 APE12-dist-na 12.9309 APE11-dist-na 10.491 APE10-dist-na 11.935 APE9-dist-in 7.2164 None PTR525 PTR525 XRAY 1.95 0.188 0.241 A 277.0 263.0 8 31 31 0 [[370, 628]] 1.0 3srv Homo sapiens TYR_SYK_HUMAN TYR 4.6e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 3SRVB P43405 364 632 635.0 S19:2 Type1 Active DFGin 6.2831 14.2364 BLAminus -130.89, -171.96 62.47, 72.82 -96.45, 25.83 293.72, 91.52 -65.61, -26.16 in-in in 7.6629 Saltbr-in 2.9666 HRD-in -72.4, -57.08 74.0, 8.38 in-in-in SNCiii in-in ActLoopNT-in 2.9744 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -91.35, 90.32 APE9-dihe-in -97.42, 146.07 APE8-dihe-in -79.19, 69.07 APE8-rot-na 34.2 APE67-dihe-in -70.71, -15.69 -52.0, -32.14 APE12-dist-na 13.2109 APE11-dist-na 10.2607 APE10-dist-na 10.8708 APE9-dist-in 6.9838 None None None XRAY 1.95 0.188 0.241 B 277.0 263.0 6 31 31 0 [[370, 628]] 1.0 3srv Homo sapiens TYR_SYK_HUMAN TYR 4.6e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 5LMAA P43405 363 632 635.0 6ZG:701 Type1 Active DFGin 6.7076 14.7541 BLAminus -128.5, -174.48 63.43, 65.54 -91.18, 18.15 286.4, 81.6 -62.6, -20.77 in-in in 8.0008 Saltbr-in 2.7693 HRD-in -78.56, -50.71 72.45, 5.63 in-in-in SNCiii in-in ActLoopNT-in 2.9274 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -59.08, 136.12 APE9-dihe-in -133.37, 70.56 APE8-dihe-in -71.66, 73.32 APE8-rot-na 31.65 APE67-dihe-in -63.61, -19.89 -49.48, -39.64 APE12-dist-na 999.0 APE11-dist-na 9.2116 APE10-dist-na 7.6988 APE9-dist-in 7.6222 None PTR525 PTR525 XRAY 1.43 0.157 0.183 A 277.0 268.0 2 31 29 2 [[370, 628]] 1.0 5lma Homo sapiens TYR_SYK_HUMAN TYR 4.6e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 5LMBA P43405 364 634 635.0 6ZF:701 Type1 Active DFGin 6.4476 14.2826 BLAminus -131.02, -173.87 62.28, 69.39 -93.16, 19.0 290.08, 82.25 -59.68, -28.46 in-in in 7.6957 Saltbr-in 2.454 HRD-in -78.06, -53.9 76.38, 4.89 in-in-in SNCiii in-in ActLoopNT-in 2.9631 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.66, 104.96 APE9-dihe-in -108.73, 152.4 APE8-dihe-in -79.7, 70.25 APE8-rot-na 31.84 APE67-dihe-in -69.34, -16.13 -51.43, -34.69 APE12-dist-na 13.0735 APE11-dist-na 10.546 APE10-dist-na 11.4482 APE9-dist-in 6.9588 None PTR525 PTR525 XRAY 1.95 0.178 0.228 A 277.0 265.0 6 31 31 0 [[370, 628]] 1.0 5lmb Homo sapiens TYR_SYK_HUMAN TYR 4.6e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 6VOVB P43405 364 633 635.0 R6D:701 Type1 Active DFGin 6.6739 14.6282 BLAminus -133.89, -172.81 60.07, 70.15 -88.26, 20.03 288.32, 89.62 -58.86, -27.32 in-in in 8.0798 Saltbr-in 2.6221 HRD-in -78.67, -51.68 71.89, 6.23 in-in-in SNCiii in-in ActLoopNT-in 2.8816 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.76, 97.82 APE9-dihe-in -115.45, 146.07 APE8-dihe-in -78.23, 69.53 APE8-rot-na 28.65 APE67-dihe-in -63.96, -14.94 -44.81, -41.99 APE12-dist-na 13.6462 APE11-dist-na 10.4481 APE10-dist-na 11.0328 APE9-dist-in 6.8137 None None None XRAY 1.95 0.22 0.268 B 281.0 264.0 6 31 31 0 [[370, 628]] 1.0 6vov Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4YJOA P43405 363 632 635.0 4DF:701 Type1 Active DFGin 7.1511 15.4037 BLAminus -136.57, 178.57 59.58, 80.7 -95.16, 22.65 286.36, 75.19 -55.96, -31.16 in-in in 8.3198 Saltbr-in 3.0437 HRD-in -80.48, -52.4 72.29, 6.84 in-in-in SNCiii in-in ActLoopNT-in 2.9567 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.5, 127.44 APE9-dihe-in -144.08, 83.31 APE8-dihe-in -75.74, 70.97 APE8-rot-na 33.07 APE67-dihe-in -63.43, -16.56 -52.99, -37.5 APE12-dist-na 999.0 APE11-dist-na 10.63 APE10-dist-na 7.9003 APE9-dist-in 7.5071 None None None XRAY 1.6 0.186 0.23 A 281.0 267.0 3 31 28 3 [[370, 628]] 1.0 4yjo Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4YJPA P43405 364 632 635.0 4DL:701 Type1 Active DFGin 6.9808 15.8243 BLAminus -136.12, -172.87 58.52, 69.5 -93.88, 23.3 283.25, 78.78 -63.0, -28.48 in-in in 8.4993 Saltbr-in 2.7873 HRD-in -81.51, -48.52 67.75, 7.04 in-in-in SNCiii in-in ActLoopNT-in 2.9447 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -52.7, 125.7 APE9-dihe-in -135.05, 78.45 APE8-dihe-in -76.25, 75.65 APE8-rot-na 35.36 APE67-dihe-in -66.34, -13.74 -58.49, -30.71 APE12-dist-na 999.0 APE11-dist-na 9.4522 APE10-dist-na 7.3693 APE9-dist-in 7.2569 None None None XRAY 1.83 0.196 0.258 A 281.0 263.0 6 31 28 3 [[370, 628]] 1.0 4yjp Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4YJSA P43405 364 632 635.0 4DN:701 Type1 Active DFGin 6.8114 15.7399 BLAminus -130.65, -173.59 54.32, 75.2 -95.58, 22.43 287.83, 71.53 -54.84, -38.21 in-in in 8.5143 Saltbr-in 3.0836 HRD-in -80.45, -49.01 70.65, 8.19 in-in-in SNCiii in-in ActLoopNT-in 2.8965 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -50.21, 136.65 APE9-dihe-in -143.79, 77.69 APE8-dihe-in -76.44, 79.91 APE8-rot-na 34.0 APE67-dihe-in -64.44, -15.73 -58.23, -33.75 APE12-dist-na 13.0696 APE11-dist-na 9.2243 APE10-dist-na 7.474 APE9-dist-in 7.0682 None None None XRAY 2.22 0.172 0.226 A 281.0 257.0 12 31 31 0 [[370, 628]] 1.0 4yjs Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 8RRQA P43405 363 632 635.0 A1H2W:701 Type1 Active DFGin 6.2148 14.4112 BLAminus -133.38, -167.55 71.76, 65.57 -94.48, 19.17 287.36, 93.75 -65.47, -22.18 in-in in 8.0815 Saltbr-in 2.8031 HRD-in -81.18, -51.78 70.8, 9.1 in-in-in SNCiii in-in ActLoopNT-in 2.9421 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.09, 108.93 APE9-dihe-in -135.72, 149.25 APE8-dihe-in -81.85, 69.97 APE8-rot-na 37.74 APE67-dihe-in -65.72, -15.06 -52.32, -34.71 APE12-dist-na 999.0 APE11-dist-na 10.2241 APE10-dist-na 10.5738 APE9-dist-in 6.7427 None PTR525,PTR526 PTR525,PTR526 XRAY 1.6 0.178 0.211 A 282.0 268.0 2 31 29 2 [[370, 628]] 1.0 8rrq Homo sapiens TYR_SYK_HUMAN TYR 4.9e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 5TT7A P43405 358 635 635.0 7KF:60901 Type1 Active DFGin 6.3107 14.3414 BLAminus -130.62, -177.29 62.11, 72.82 -94.96, 21.67 289.95, 80.8 -60.6, -26.94 in-in in 7.7094 Saltbr-in 2.8404 HRD-in -77.7, -52.28 69.96, 13.2 in-in-in SNCiii in-in ActLoopNT-in 2.8781 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.65, 88.09 APE9-dihe-in -107.14, 140.48 APE8-dihe-in -78.3, 78.38 APE8-rot-na 32.04 APE67-dihe-in -64.56, -15.37 -56.64, -35.35 APE12-dist-na 13.888 APE11-dist-na 10.557 APE10-dist-na 10.3425 APE9-dist-in 6.8486 None None None XRAY 1.77 0.208 0.234 A 289.0 270.0 8 31 31 0 [[370, 628]] 1.0 5tt7 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 8XQ0A P43405 364 634 635.0 A1LV4:701 Type1 Active DFGin 6.1538 14.7431 BLAminus -131.25, -165.27 59.08, 66.28 -91.94, 24.84 295.79, 89.46 -66.54, -26.0 in-in in 8.8405 Saltbr-in 2.3901 HRD-in -77.49, -50.4 67.59, 11.98 in-in-in SNCiii in-in ActLoopNT-in 2.7629 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.4, 148.65 APE9-dihe-in -142.22, 83.4 APE8-dihe-in -79.88, 80.85 APE8-rot-na 30.05 APE67-dihe-in -71.39, -10.32 -63.91, -29.36 APE12-dist-na 999.0 APE11-dist-na 8.6608 APE10-dist-na 7.4649 APE9-dist-in 7.0838 None None None XRAY 1.95 0.222 0.265 A 290.0 264.0 7 31 27 4 [[370, 628]] 1.0 8xq0 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 8XQ0C P43405 364 633 635.0 A1LV4:701 Type1 Active DFGin 6.0637 14.7714 BLAminus -131.08, -166.05 60.61, 65.77 -92.17, 22.95 297.06, 91.43 -65.35, -22.59 in-in in 8.197 Saltbr-in 2.4741 HRD-in -81.66, -50.49 70.19, 9.23 in-in-in SNCiii in-in ActLoopNT-in 2.8624 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.0, 152.43 APE9-dihe-in -139.04, 83.13 APE8-dihe-in -80.21, 76.04 APE8-rot-na 29.28 APE67-dihe-in -67.25, -12.04 -57.38, -34.01 APE12-dist-na 999.0 APE11-dist-na 8.5474 APE10-dist-na 7.75 APE9-dist-in 7.1856 None None None XRAY 1.95 0.222 0.265 C 290.0 263.0 7 31 28 3 [[370, 628]] 1.0 8xq0 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 1XBCA P43405 363 635 635.0 STU:60001 Type1 Active DFGin 6.6992 14.2365 BLAminus -133.2, -171.25 54.9, 81.04 -97.63, 25.87 287.7, 80.31 -62.67, -30.77 in-in in 8.107 Saltbr-in 2.6812 HRD-in -73.91, -54.08 72.64, 5.62 in-in-in SNCiii in-in ActLoopNT-in 2.8734 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.93, 102.31 APE9-dihe-in -115.14, 122.86 APE8-dihe-in -77.21, 74.28 APE8-rot-na 27.13 APE67-dihe-in -62.04, -14.77 -51.56, -42.64 APE12-dist-na 10.2255 APE11-dist-na 10.6613 APE10-dist-na 9.591 APE9-dist-in 6.8302 None None None XRAY 2.0 0.246 0.294 A 291.0 267.0 6 31 31 0 [[370, 628]] 1.0 1xbc Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 3FQHA P43405 363 634 635.0 057:1 Type1 Active DFGin 6.3887 14.2934 BLAminus -136.21, -174.07 56.01, 83.39 -99.37, 22.02 289.52, 83.78 -53.8, -32.62 in-in in 7.9894 Saltbr-in 2.9827 HRD-in -76.47, -53.05 70.67, 6.23 in-in-in SNCiii in-in ActLoopNT-in 2.7712 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.93, 113.08 APE9-dihe-in -110.56, 145.62 APE8-dihe-in -76.43, 69.28 APE8-rot-na 29.47 APE67-dihe-in -67.72, -12.14 -50.67, -39.65 APE12-dist-na 12.19 APE11-dist-na 10.4595 APE10-dist-na 11.2703 APE9-dist-in 6.9934 None None None XRAY 2.26 0.216 0.259 A 291.0 262.0 10 31 31 0 [[370, 628]] 1.0 3fqh Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4GFGA P43405 363 635 635.0 0XF:60701 Type1 Active DFGin 6.3816 14.7063 BLAminus -133.41, -165.6 61.44, 68.78 -94.44, 29.51 290.84, 74.86 -64.09, -30.1 in-in in 8.5511 Saltbr-in 3.4972 HRD-in -86.12, -47.8 68.36, 5.25 in-in-in SNCiii in-in ActLoopNT-in 2.8664 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -53.12, 138.6 APE9-dihe-in -110.15, 137.21 APE8-dihe-in -65.63, 68.92 APE8-rot-na 25.72 APE67-dihe-in -68.08, -17.47 -52.98, -35.53 APE12-dist-na 9.5817 APE11-dist-na 10.6292 APE10-dist-na 11.7062 APE9-dist-in 7.231 None None None XRAY 2.35 0.221 0.246 A 291.0 273.0 0 31 31 0 [[370, 628]] 1.0 4gfg Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 5TIUA P43405 363 635 635.0 7CU:60701 Type1 Active DFGin 6.578 14.3657 BLAminus -131.38, -173.31 61.91, 73.7 -95.93, 19.79 288.63, 86.78 -61.17, -26.75 in-in in 7.8012 Saltbr-in 2.7346 HRD-in -74.96, -48.82 70.27, 6.32 in-in-in SNCiii in-in ActLoopNT-in 2.9019 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.61, 84.89 APE9-dihe-in -101.52, 144.24 APE8-dihe-in -80.61, 68.84 APE8-rot-na 28.9 APE67-dihe-in -65.13, -16.04 -45.65, -40.25 APE12-dist-na 13.9624 APE11-dist-na 10.8435 APE10-dist-na 10.6887 APE9-dist-in 7.0997 None None None XRAY 1.49 0.186 0.203 A 291.0 262.0 11 31 31 0 [[370, 628]] 1.0 5tiu Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 5Y5TA P43405 363 635 635.0 8OR:701 Type1 Active DFGin 6.6305 14.7164 BLAminus -124.89, -179.45 65.71, 71.78 -93.94, 17.9 289.28, 88.8 -59.66, -30.83 in-in in 8.0451 Saltbr-in 2.706 HRD-in -76.54, -52.99 73.97, 1.93 in-in-in SNCiii in-in ActLoopNT-in 2.9217 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -91.38, 59.43 APE9-dihe-in -101.74, 134.18 APE8-dihe-in -79.02, 75.85 APE8-rot-na 32.57 APE67-dihe-in -64.44, -15.76 -52.79, -38.69 APE12-dist-na 8.8122 APE11-dist-na 11.9308 APE10-dist-na 9.7116 APE9-dist-in 6.9908 None None None XRAY 1.8 0.196 0.234 A 293.0 263.0 10 31 31 0 [[370, 628]] 1.0 5y5t Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 5Y5UA P43405 364 634 635.0 8OU:701 Type1 Active DFGin 6.4344 14.0988 BLAminus -136.65, 173.94 66.9, 89.62 -105.43, 28.84 296.27, 90.39 -60.97, -30.93 in-in in 7.9941 Saltbr-in 2.5848 HRD-in -70.93, -52.74 73.81, 2.31 in-in-in SNCiii in-in ActLoopNT-in 2.7997 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.85, 121.36 APE9-dihe-in -125.49, 151.88 APE8-dihe-in -80.17, 69.97 APE8-rot-na 36.19 APE67-dihe-in -65.59, -17.51 -56.34, -35.15 APE12-dist-na 13.3247 APE11-dist-na 10.8666 APE10-dist-na 11.8021 APE9-dist-in 7.2259 None None None XRAY 2.14 0.239 0.26 A 293.0 266.0 5 31 31 0 [[370, 628]] 1.0 5y5u Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4WNMA P43405 347 635 635.0 3RT:60701 Type1 Active DFGin 6.2685 14.2043 BLAminus -122.7, 177.9 75.28, 74.2 -103.7, 21.48 302.37, 85.65 -56.81, -27.59 in-in in 8.2793 Saltbr-in 2.749 HRD-in -73.5, -57.83 70.01, 16.8 in-in-in SNCiii in-in ActLoopNT-in 2.8697 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -49.99, 114.81 APE9-dihe-in -116.39, 136.86 APE8-dihe-in -71.67, 69.27 APE8-rot-na 29.91 APE67-dihe-in -63.86, -22.22 -60.87, -29.91 APE12-dist-na 12.4085 APE11-dist-na 9.7166 APE10-dist-na 10.7384 APE9-dist-in 7.1211 None None None XRAY 2.5 0.207 0.26 A 299.0 272.0 4 31 31 0 [[370, 628]] 1.0 4wnm Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 5C26A P43405 363 635 635.0 50H:60701 Type1 Active DFGin 6.4069 14.9052 BLAminus -133.47, -175.05 59.93, 80.73 -95.24, 23.48 291.98, 89.4 -57.38, -35.1 in-in in 8.2315 Saltbr-in 2.7559 HRD-in -77.18, -53.12 70.55, 7.56 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.23, 98.53 APE9-dihe-in -110.63, 147.85 APE8-dihe-in -78.58, 69.25 APE8-rot-na 30.18 APE67-dihe-in -65.45, -18.57 -48.55, -37.73 APE12-dist-na 13.3107 APE11-dist-na 10.5734 APE10-dist-na 10.5924 APE9-dist-in 6.8401 None PTR525,PTR526 PTR525,PTR526 XRAY 1.95 0.186 0.215 A 299.0 273.0 0 31 31 0 [[370, 628]] 1.0 5c26 Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 5C27A P43405 363 635 635.0 50J:60701 Type1 Active DFGin 6.3587 14.6118 BLAminus -130.06, -175.69 60.48, 84.21 -100.61, 25.88 296.18, 90.13 -67.7, -23.97 in-in in 8.3245 Saltbr-in 2.7902 HRD-in -75.03, -53.41 71.91, 4.7 in-in-in SNCiii in-in ActLoopNT-in 3.0014 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.32, 89.13 APE9-dihe-in -103.36, 145.0 APE8-dihe-in -82.82, 67.41 APE8-rot-na 29.25 APE67-dihe-in -67.99, -14.11 -44.6, -40.88 APE12-dist-na 13.3733 APE11-dist-na 10.0379 APE10-dist-na 10.0822 APE9-dist-in 6.7508 None PTR525,PTR526 PTR525,PTR526 XRAY 2.15 0.179 0.225 A 299.0 273.0 0 31 31 0 [[370, 628]] 1.0 5c27 Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 6ZC0A P43405 363 635 635.0 QDZ:60701 Type1 Active DFGin 6.4395 14.2562 BLAminus -134.4, -168.89 64.15, 77.73 -98.13, 17.43 287.82, 84.9 -56.42, -33.19 in-in in 7.8053 Saltbr-in 3.3022 HRD-in -74.71, -54.58 68.95, 18.65 in-in-in SNCiii in-in ActLoopNT-in 2.8699 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.33, 89.82 APE9-dihe-in -113.19, 137.33 APE8-dihe-in -88.05, 72.58 APE8-rot-na 31.66 APE67-dihe-in -60.74, -19.2 -42.14, -42.2 APE12-dist-na 13.5898 APE11-dist-na 10.0879 APE10-dist-na 9.2847 APE9-dist-in 6.8334 None None None XRAY 1.97 0.194 0.229 A 299.0 264.0 9 31 31 0 [[370, 628]] 1.0 6zc0 Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 6ZCPA P43405 363 635 635.0 QFK:60701 Type1 Active DFGin 6.4336 14.1142 BLAminus -125.39, -166.55 56.04, 77.4 -99.95, 22.28 287.9, 88.75 -70.24, -19.9 in-in in 8.0898 Saltbr-in 3.2303 HRD-in -73.61, -47.62 64.51, 7.94 in-in-in SNCiii in-in ActLoopNT-in 2.9329 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.33, 97.29 APE9-dihe-in -119.56, 130.58 APE8-dihe-in -81.48, 76.65 APE8-rot-na 28.01 APE67-dihe-in -69.79, -11.02 -50.04, -33.72 APE12-dist-na 13.9828 APE11-dist-na 11.0182 APE10-dist-na 10.323 APE9-dist-in 7.2576 None None None XRAY 2.2 0.213 0.234 A 299.0 264.0 9 31 31 0 [[370, 628]] 1.0 6zcp Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4RX7A P43405 363 635 635.0 3YV:60703 Type1 Active DFGin 6.3677 14.5099 BLAminus -135.93, -162.06 57.15, 54.11 -83.47, 19.55 290.31, 87.83 -58.61, -26.4 in-in in 8.1507 Saltbr-in 2.9061 HRD-in -74.07, -52.97 72.74, 4.77 in-in-in SNCiii in-in ActLoopNT-in 2.9294 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.3, 124.77 APE9-dihe-in -107.76, 142.43 APE8-dihe-in -82.91, 72.86 APE8-rot-na 31.05 APE67-dihe-in -64.64, -19.89 -48.22, -37.19 APE12-dist-na 12.6465 APE11-dist-na 10.9772 APE10-dist-na 11.2212 APE9-dist-in 7.1341 None None None XRAY 1.8 0.182 0.203 A 289.0 270.0 3 31 31 0 [[370, 628]] 1.0 4rx7 Homo sapiens TYR_SYK_HUMAN TYR 3.9e-90 307.6 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4RX8A P43405 364 635 635.0 3YX:60703 Type1 Active DFGin 6.3748 14.3435 BLAminus -127.63, -170.0 62.54, 75.55 -100.59, 22.48 287.33, 90.81 -63.45, -25.44 in-in in 8.0344 Saltbr-in 2.8413 HRD-in -76.4, -50.39 68.53, 9.44 in-in-in SNCiii in-in ActLoopNT-in 2.9288 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.6, 95.02 APE9-dihe-in -111.13, 149.03 APE8-dihe-in -81.54, 69.96 APE8-rot-na 29.76 APE67-dihe-in -66.91, -14.89 -51.35, -37.09 APE12-dist-na 999.0 APE11-dist-na 10.7148 APE10-dist-na 10.6212 APE9-dist-in 6.9816 None None None XRAY 1.59 0.175 0.207 A 289.0 266.0 6 31 30 1 [[370, 628]] 1.0 4rx8 Homo sapiens TYR_SYK_HUMAN TYR 3.9e-90 307.6 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 5CXHA P43405 363 635 635.0 55M:60701 Type1 Active DFGin 6.4399 14.3226 BLAminus -133.42, -179.45 56.74, 83.68 -97.45, 24.47 292.79, 86.46 -58.74, -36.41 in-in in 7.6617 Saltbr-in 2.8584 HRD-in -70.81, -53.82 70.99, 7.51 in-in-in SNCiii in-in ActLoopNT-in 2.9745 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.96, 96.35 APE9-dihe-in -104.24, 139.79 APE8-dihe-in -78.53, 71.61 APE8-rot-na 29.83 APE67-dihe-in -66.63, -19.71 -51.23, -33.62 APE12-dist-na 13.1233 APE11-dist-na 10.8367 APE10-dist-na 10.8797 APE9-dist-in 7.0521 K467T None None XRAY 1.9 0.176 0.205 A 289.0 273.0 0 31 31 0 [[370, 628]] 1.0 5cxh Homo sapiens TYR_SYK_HUMAN TYR 3.9e-90 307.6 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4RX9A P43405 363 635 635.0 3YT:60702 Type1 Active DFGin 6.5363 14.4979 BLAminus -131.55, -166.02 53.8, 76.49 -95.21, 18.16 288.88, 90.96 -57.69, -29.73 in-in in 8.1675 Saltbr-in 3.1254 HRD-in -77.32, -52.67 70.66, 10.77 in-in-in SNCiii in-in ActLoopNT-in 2.9602 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.14, 87.16 APE9-dihe-in -107.75, 147.74 APE8-dihe-in -79.62, 70.69 APE8-rot-na 28.2 APE67-dihe-in -66.03, -15.15 -48.72, -38.82 APE12-dist-na 999.0 APE11-dist-na 11.0764 APE10-dist-na 10.7611 APE9-dist-in 6.9972 None None None XRAY 1.75 0.175 0.197 A 290.0 264.0 9 31 30 1 [[370, 628]] 1.0 4rx9 Homo sapiens TYR_SYK_HUMAN TYR 4e-90 307.6 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 5CY3A P43405 360 635 635.0 55Y:60701 Type1 Active DFGin 6.2954 14.6111 BLAminus -132.49, 178.84 54.8, 80.29 -90.47, 18.93 290.07, 88.96 -55.0, -39.22 in-in in 8.1966 Saltbr-in 2.7629 HRD-in -80.6, -49.34 69.47, 8.41 in-in-in SNCiii in-in ActLoopNT-in 2.9491 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.58, 101.42 APE9-dihe-in -106.21, 146.28 APE8-dihe-in -84.7, 72.08 APE8-rot-na 31.82 APE67-dihe-in -66.44, -12.67 -53.8, -35.38 APE12-dist-na 13.3826 APE11-dist-na 10.3613 APE10-dist-na 10.9874 APE9-dist-in 7.136 K467T None None XRAY 1.76 0.171 0.195 A 291.0 274.0 2 31 31 0 [[370, 628]] 1.0 5cy3 Homo sapiens TYR_SYK_HUMAN TYR 4e-90 307.6 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4DFLA P43405 363 635 635.0 0K0:60701 Type1 Inactive DFGin 6.483 14.5712 BLAminus -118.07, -176.51 65.46, 77.03 -97.43, 24.23 290.23, 82.73 -67.62, -27.84 in-in in 8.4441 Saltbr-in 3.1343 HRD-in -79.8, -55.87 75.57, 9.89 in-in-out SNCiio in-out ActLoopNT-in 2.9479 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 50.15, 72.02 APE9-dihe-in -112.79, 133.67 APE8-dihe-in -76.3, 73.19 APE8-rot-na 32.11 APE67-dihe-in -65.46, -14.43 -51.92, -39.05 APE12-dist-na 13.0467 APE11-dist-na 10.3491 APE10-dist-na 9.7612 APE9-dist-in 6.7989 None None None XRAY 1.98 0.199 0.243 A 274.0 262.0 11 31 31 0 [[370, 628]] 1.0 4dfl Homo sapiens TYR_SYK_HUMAN TYR 4.4e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4YJQA P43405 364 633 635.0 4DK:701 Type1 Inactive DFGin 6.736 15.804 BLAminus -134.82, -177.19 61.29, 79.22 -100.06, 24.96 286.87, 77.55 -63.45, -29.36 in-out in 8.7579 Saltbr-out 4.8949 HRD-in -81.67, -53.67 71.29, 13.22 out-in-in SNCoii in-in ActLoopNT-in 2.9096 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.36, 108.33 APE9-dihe-in -126.44, 157.88 APE8-dihe-in -80.8, 70.11 APE8-rot-na 32.3 APE67-dihe-in -67.03, -13.75 -58.2, -31.61 APE12-dist-na 13.8615 APE11-dist-na 10.9307 APE10-dist-na 11.3078 APE9-dist-in 6.8938 None PTR525,PTR526 PTR525,PTR526 XRAY 1.34 0.162 0.183 A 281.0 266.0 4 31 31 0 [[370, 628]] 1.0 4yjq Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4YJRA P43405 364 633 635.0 4DJ:701 Type1 Inactive DFGin 6.6242 15.8872 BLAminus -132.72, -177.45 60.79, 79.89 -101.88, 24.11 286.03, 77.25 -63.73, -27.17 in-out in 8.7801 Saltbr-out 4.8064 HRD-in -81.52, -53.74 71.69, 12.94 out-in-in SNCoii in-in ActLoopNT-in 2.9278 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.41, 106.79 APE9-dihe-in -125.28, 158.73 APE8-dihe-in -81.3, 69.56 APE8-rot-na 32.68 APE67-dihe-in -66.27, -14.56 -57.04, -32.84 APE12-dist-na 13.842 APE11-dist-na 10.8871 APE10-dist-na 11.2377 APE9-dist-in 6.8596 None PTR525,PTR526 PTR525,PTR526 XRAY 1.32 0.157 0.18 A 281.0 265.0 5 31 31 0 [[370, 628]] 1.0 4yjr Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4YJTA P43405 364 633 635.0 4DQ:702 Type1 Inactive DFGin 7.0639 15.5817 BLAminus -131.45, -174.52 58.96, 73.99 -96.84, 26.0 284.85, 76.07 -63.21, -26.17 in-out in 8.6666 Saltbr-out 3.8109 HRD-in -83.12, -51.93 70.87, 9.98 out-in-in SNCoii in-in ActLoopNT-in 2.8931 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.18, 103.7 APE9-dihe-in -124.22, 158.86 APE8-dihe-in -80.04, 67.83 APE8-rot-na 30.81 APE67-dihe-in -66.36, -14.14 -52.34, -34.06 APE12-dist-na 14.1006 APE11-dist-na 10.8881 APE10-dist-na 11.1136 APE9-dist-in 6.8625 None PTR525,PTR526 PTR525,PTR526 XRAY 1.52 0.176 0.208 A 281.0 270.0 0 31 31 0 [[370, 628]] 1.0 4yjt Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4YJUA P43405 364 633 635.0 4DO:701 Type1 Inactive DFGin 7.1075 15.3802 BLAminus -134.61, -176.9 55.67, 76.17 -94.03, 20.15 284.44, 74.82 -57.56, -25.54 in-out in 8.5742 Saltbr-out 3.7569 HRD-in -78.76, -50.17 71.23, 5.94 out-in-in SNCoii in-in ActLoopNT-in 2.8608 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.06, 116.81 APE9-dihe-in -121.69, 162.72 APE8-dihe-in -76.87, 70.03 APE8-rot-na 31.7 APE67-dihe-in -64.01, -12.06 -45.6, -41.35 APE12-dist-na 999.0 APE11-dist-na 11.4211 APE10-dist-na 11.9034 APE9-dist-in 6.8276 None PTR525,PTR526 PTR525,PTR526 XRAY 1.67 0.168 0.201 A 281.0 267.0 3 31 28 3 [[370, 628]] 1.0 4yju Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4YJVA P43405 364 633 635.0 4DT:701 Type1 Inactive DFGin 7.0581 15.5393 BLAminus -132.12, -177.62 58.9, 78.21 -97.23, 24.66 284.8, 77.05 -61.21, -27.61 in-out in 8.6007 Saltbr-out 4.9613 HRD-in -80.51, -52.41 71.92, 9.69 out-in-in SNCoii in-in ActLoopNT-in 2.9031 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.0, 101.75 APE9-dihe-in -120.35, 161.01 APE8-dihe-in -81.1, 68.03 APE8-rot-na 32.46 APE67-dihe-in -66.69, -14.4 -54.32, -33.4 APE12-dist-na 13.9186 APE11-dist-na 10.7998 APE10-dist-na 11.1557 APE9-dist-in 6.8381 None PTR525,PTR526 PTR525,PTR526 XRAY 1.652 0.177 0.222 A 281.0 265.0 5 31 31 0 [[370, 628]] 1.0 4yjv Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4RSSA P43405 364 634 635.0 4MG:701 Type1 Inactive DFGin 6.3619 14.3745 BLAminus -125.51, 178.89 70.7, 70.71 -93.1, 15.53 292.82, 95.43 -58.12, -23.53 in-in in 7.9804 Saltbr-in 2.6475 HRD-in -80.43, -50.69 72.79, 4.21 in-in-out SNCiio in-out ActLoopNT-in 2.9832 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -83.33, -31.98 APE9-dihe-out -62.19, -39.48 APE8-dihe-out -88.75, -5.81 APE8-rot-na 36.86 APE67-dihe-in -61.38, -18.45 -51.57, -40.88 APE12-dist-na 11.1951 APE11-dist-na 13.649 APE10-dist-na 16.6325 APE9-dist-out 10.4074 None None None XRAY 1.83 0.214 0.249 A 290.0 269.0 2 31 31 0 [[370, 628]] 1.0 4rss Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4XG3A P43405 363 634 635.0 X3G:701 Type1 Inactive DFGin 6.561 14.2694 BLAminus -123.77, -176.77 60.27, 75.02 -93.24, 14.93 290.25, 93.45 -52.4, -30.37 in-out in 7.8828 Saltbr-out 4.3726 HRD-in -78.91, -49.84 68.75, 12.99 out-in-in SNCoii in-in ActLoopNT-in 2.8119 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.51, 96.9 APE9-dihe-in -112.53, 139.55 APE8-dihe-in -74.31, 78.49 APE8-rot-na 32.23 APE67-dihe-in -68.63, -15.73 -57.45, -34.9 APE12-dist-na 14.073 APE11-dist-na 11.0053 APE10-dist-na 10.9134 APE9-dist-in 7.1563 None None None XRAY 2.3 0.199 0.226 A 290.0 262.0 10 31 31 0 [[370, 628]] 1.0 4xg3 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4XG7A P43405 364 635 635.0 X7G:60701 Type1 Inactive DFGin 6.4465 14.3234 BLAminus -121.7, -179.92 65.73, 76.06 -96.8, 16.58 293.04, 92.3 -59.19, -26.5 in-in in 7.7856 Saltbr-in 2.689 HRD-in -75.48, -50.53 70.33, 10.44 in-in-out SNCiio in-out ActLoopNT-in 2.9192 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -77.68, -30.64 APE9-dihe-out -62.97, -34.6 APE8-dihe-out -91.68, -6.53 APE8-rot-na 34.14 APE67-dihe-in -64.14, -15.96 -52.05, -39.51 APE12-dist-na 11.1281 APE11-dist-na 13.4773 APE10-dist-na 16.5682 APE9-dist-out 10.3334 None None None XRAY 1.76 0.226 0.242 A 290.0 265.0 7 31 31 0 [[370, 628]] 1.0 4xg7 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4XG8A P43405 366 635 635.0 X8G:700 Type1 Inactive DFGin 6.3914 14.632 BLAminus -120.1, -177.66 66.71, 68.41 -88.21, 14.67 295.9, 86.73 -47.78, -34.81 in-out in 8.2587 Saltbr-out 5.0054 HRD-in -67.74, -56.67 79.0, 1.4 out-in-none SNCoin in-none ActLoopNT-in 2.8079 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 10.07 APE8-rot-na 35.22 APE67-dihe-in -73.7, -4.5 -52.82, -36.93 APE12-dist-na 11.6364 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.249 0.275 A 290.0 258.0 12 31 28 3 [[370, 628]] 1.0 4xg8 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4I0TA P43405 363 635 635.0 1B6:60701 Type1 Inactive DFGin 6.4477 14.2754 BLAminus -133.28, -166.54 54.17, 83.04 -99.17, 23.72 289.92, 92.88 -54.78, -30.8 in-in in 8.4819 Saltbr-in 2.757 HRD-in -78.62, -52.01 75.91, 3.75 in-in-out SNCiio in-out ActLoopNT-in 3.0051 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.47 APE8-dihe-in -63.58, 54.66 APE8-rot-na 27.19 APE67-dihe-in -65.32, -17.31 -39.09, -36.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.5617 None None None XRAY 1.7 0.236 0.268 A 291.0 262.0 11 31 26 5 [[370, 628]] 1.0 4i0t Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 3EMGA P43405 365 631 635.0 685:685 Type1 Inactive DFGin 6.4238 14.4354 BLAminus -130.99, -164.55 52.75, 65.2 -80.56, 24.97 299.65, 78.19 -64.0, -22.78 in-out in 8.1476 Saltbr-out 3.9691 HRD-in -79.71, -50.4 83.15, -12.3 out-in-none SNCoin in-none ActLoopNT-in 3.0609 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -116.55 APE9-dihe-in -116.09, 161.75 APE8-dihe-in -79.75, 74.02 APE8-rot-na 34.39 APE67-dihe-in -47.92, -26.61 -60.2, -39.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.8953 APE9-dist-in 7.2889 None None None XRAY 2.6 0.2 0.222 A 291.0 255.0 12 31 27 4 [[370, 628]] 1.0 3emg Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4FL3A P43405 9 635 635.0 ANP:701 ATPlike Inactive DFGin 5.2707 12.4112 BLBplus -116.27, 169.06 58.02, 22.77 -60.26, 128.95 39.87, 90.8 70.36, 3.28 out-out out 13.3472 Saltbr-out 12.957 HRD-in -71.66, -54.51 80.39, -19.8 out-out-none SNCoon out-none ActLoopNT-out 7.0299 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 2.25 APE8-rot-na 29.04 APE67-dihe-in -63.72, -20.72 -59.66, -31.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y348F,Y352F None None XRAY 1.9 0.18 0.208 A 635.0 538.0 13 31 18 13 [[370, 628]] 1.0 4fl3 Homo sapiens TYR_SYK_HUMAN TYR 5.1e-89 304.2 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4FL2A P43405 9 635 635.0 ANP:702 ATPlike Inactive DFGin 5.4285 12.3278 BLBplus -115.2, 163.41 55.5, 31.26 -66.72, 128.2 35.56, 90.39 65.72, 13.6 out-out out 13.4906 Saltbr-out 13.2027 HRD-in -70.05, -49.77 75.03, -15.27 out-out-out SNCooo out-out ActLoopNT-out 7.1942 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.16, 144.55 APE9-dihe-in -104.91, 94.8 APE8-dihe-out -50.62, -30.17 APE8-rot-na 333.32 APE67-dihe-in -61.99, -18.29 -62.08, -21.97 APE12-dist-na 15.5558 APE11-dist-na 19.2065 APE10-dist-na 15.7365 APE9-dist-out 11.5275 None None None XRAY 2.19 0.184 0.228 A 636.0 555.0 0 31 31 0 [[370, 628]] 1.0 4fl2 Homo sapiens TYR_SYK_HUMAN TYR 5.1e-89 304.2 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 3TUCA P43405 358 633 635.0 FPW:999 Type1.5_Front Inactive DFGin 6.5557 15.0193 BLBplus -114.33, 165.27 53.65, 40.82 -73.1, 146.31 90.45, 83.64 -43.15, -55.01 out-out out 11.4709 Saltbr-out 7.0679 HRD-in -66.05, -58.66 86.11, -25.8 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.49 APE8-rot-na 24.54 APE67-dihe-in -67.39, -16.05 -47.1, -39.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.216 0.285 A 299.0 257.0 19 31 12 19 [[370, 628]] 1.0 3tuc Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 3TUBA P43405 362 633 635.0 FPU:999 Type2 Inactive DFGout 13.74 9.6702 BBAminus -126.08, 171.13 -141.46, 68.74 -40.79, -49.16 289.47, 103.31 -92.66, 19.79 in-out in 8.3161 Saltbr-out 3.6672 HRD-in -62.48, -58.18 81.87, -14.31 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 55.79 APE8-rot-na 29.91 APE67-dihe-in -67.44, -14.12 -48.38, -36.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.23 0.182 0.232 A 293.0 253.0 19 31 12 19 [[370, 628]] 1.0 3tub Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 3TUDA P43405 363 635 635.0 FPX:60001 Type2 Inactive DFGout 15.3086 10.8657 None -123.06, 178.93 -154.97, 96.56 -80.58, 999.0 302.91, 174.18 999.0, 999.0 in-in in 8.7502 Saltbr-in 2.7565 HRD-in -65.87, -59.08 79.62, -13.62 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -60.05, 129.63 APE9-dihe-in -111.2, 153.71 APE8-dihe-in -83.04, 71.46 APE8-rot-na 31.48 APE67-dihe-in -66.5, -12.19 -53.72, -36.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.652 None None None XRAY 2.33 0.198 0.263 A 299.0 255.0 18 31 13 18 [[370, 628]] 1.0 3tud Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4XG2A P43405 364 635 635.0 No_ligand No_ligand None DFGin 6.5597 14.743 BLAminus -130.24, -178.99 62.72, 77.6 -96.14, 15.75 290.58, 78.21 -62.22, -24.62 in-in in 8.1887 Saltbr-in 2.79 HRD-in -76.73, -52.8 72.67, 7.33 in-in-none SNCiin in-none ActLoopNT-in 2.8566 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 129.75 APE9-dihe-in -121.46, 135.12 APE8-dihe-in -76.71, 74.12 APE8-rot-na 35.22 APE67-dihe-in -65.91, -17.02 -54.02, -32.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.9026 APE9-dist-in 7.0565 None None None XRAY 2.21 0.204 0.227 A 290.0 258.0 14 31 27 4 [[370, 628]] 1.0 4xg2 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 6HM7A P43405 363 633 635.0 GDH:701 Type1 None DFGin 6.5526 14.5265 BLAminus -123.85, -179.77 64.31, 73.15 -92.84, 18.31 290.79, 83.99 -60.41, -28.58 in-in in 8.0331 Saltbr-in 2.9282 HRD-in -76.88, -50.91 71.45, 2.92 in-in-none SNCiin in-none ActLoopNT-in 2.9037 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 157.3 APE8-dihe-in -78.81, 69.42 APE8-rot-na 32.62 APE67-dihe-in -63.42, -18.8 -55.15, -34.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5684 None PTR525 PTR525 XRAY 1.64 0.174 0.21 A 276.0 268.0 3 31 28 3 [[370, 628]] 1.0 6hm7 Homo sapiens TYR_SYK_HUMAN TYR 4.5e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 5LMBB P43405 364 630 635.0 6ZF:701 Type1 None DFGin 6.5417 14.2074 BLAminus -133.05, -174.7 62.98, 72.21 -97.02, 21.38 290.54, 88.36 -62.52, -32.46 in-in in 7.7365 Saltbr-in 2.5556 HRD-in -77.26, -52.74 74.6, 8.57 in-in-none SNCiin in-none ActLoopNT-in 2.872 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.43 APE8-dihe-in -80.7, 73.18 APE8-rot-na 30.16 APE67-dihe-in -64.42, -18.25 -49.18, -37.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.9476 None PTR525 PTR525 XRAY 1.95 0.178 0.228 B 277.0 262.0 5 31 26 5 [[370, 628]] 1.0 5lmb Homo sapiens TYR_SYK_HUMAN TYR 4.6e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 8X5KA P43405 363 632 635.0 3YT:701 Type1 None DFGin 6.3819 14.6558 BLAminus -132.21, -172.26 63.3, 68.78 -95.24, 19.38 292.18, 89.98 -56.7, -30.78 in-in in 7.8942 Saltbr-in 2.95 HRD-in -71.77, -56.19 75.58, 0.61 in-in-none SNCiin in-none ActLoopNT-in 2.9476 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.95 APE8-rot-na 32.78 APE67-dihe-in -63.64, -18.99 -57.25, -32.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.192 0.244 A 280.0 264.0 6 31 26 5 [[370, 628]] 1.0 8x5k Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 6VOVA P43405 363 629 635.0 R6D:701 Type1 None DFGin 6.4909 14.5508 BLAminus -133.59, -172.02 59.62, 69.16 -89.35, 17.8 288.33, 91.38 -60.0, -27.27 in-in in 7.9938 Saltbr-in 2.6903 HRD-in -77.79, -51.77 71.65, 6.09 in-in-none SNCiin in-none ActLoopNT-in 2.9903 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.03 APE8-dihe-in -78.95, 69.83 APE8-rot-na 28.75 APE67-dihe-in -65.35, -15.72 -44.66, -41.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.1965 None None None XRAY 1.95 0.22 0.268 A 281.0 258.0 9 31 27 4 [[370, 628]] 1.0 6vov Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 8RRZA P43405 363 633 635.0 A1H2Y:701 Type1 None DFGin 6.4609 14.6821 BLAminus -127.74, -179.45 67.79, 70.28 -94.76, 22.67 287.65, 98.81 -62.91, -34.06 in-in in 7.9641 Saltbr-in 2.8975 HRD-in -78.47, -50.78 73.26, 5.22 in-in-none SNCiin in-none ActLoopNT-in 2.9387 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.18 APE8-dihe-in -75.14, 72.0 APE8-rot-na 32.71 APE67-dihe-in -61.9, -17.04 -54.99, -37.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.332 None PTR525,PTR526 PTR525,PTR526 XRAY 1.75 0.182 0.214 A 282.0 262.0 9 31 27 4 [[370, 628]] 1.0 8rrz Homo sapiens TYR_SYK_HUMAN TYR 4.9e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 5TR6A P43405 362 635 635.0 7KG:60701 Type1 None DFGin 6.42 14.4222 BLAminus -132.48, 179.72 59.87, 74.11 -95.94, 22.5 287.39, 87.93 -67.35, -26.8 in-none in 7.9927 Saltbr-none 999.0 HRD-in -77.83, -50.78 68.92, 14.83 none-in-in SNCnii in-in ActLoopNT-in 2.9205 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.28, 93.77 APE9-dihe-in -107.16, 142.31 APE8-dihe-in -78.63, 77.12 APE8-rot-na 32.22 APE67-dihe-in -65.12, -14.48 -58.58, -35.04 APE12-dist-na 13.6817 APE11-dist-na 10.1638 APE10-dist-na 10.5072 APE9-dist-in 6.9749 None None None XRAY 1.93 0.195 0.217 A 289.0 268.0 6 31 31 0 [[370, 628]] 1.0 5tr6 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4XG3B P43405 363 633 635.0 X3G:701 Type1 None DFGin 6.3613 14.2596 BLAminus -128.52, -176.24 59.83, 77.98 -95.46, 17.98 292.06, 88.72 -55.83, -35.07 in-in in 7.7571 Saltbr-in 2.7128 HRD-in -74.45, -44.97 66.32, 3.24 in-in-none SNCiin in-none ActLoopNT-in 3.0381 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 60.87 APE9-dihe-in -106.83, 127.91 APE8-dihe-in -75.62, 80.4 APE8-rot-na 32.03 APE67-dihe-in -68.27, -18.81 -58.02, -33.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.7584 APE9-dist-in 7.1331 None None None XRAY 2.3 0.199 0.226 B 290.0 267.0 4 31 27 4 [[370, 628]] 1.0 4xg3 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4XG4A P43405 363 635 635.0 X4G:701 Type1 None DFGin 6.6332 14.4996 BLAminus -121.07, 179.74 64.97, 74.28 -96.12, 21.86 293.04, 85.88 -61.26, -26.24 in-in in 7.9365 Saltbr-in 2.6714 HRD-in -75.83, -50.72 70.19, 14.15 in-in-none SNCiin in-none ActLoopNT-in 2.9335 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 92.08 APE9-dihe-in -117.97, 139.01 APE8-dihe-in -75.6, 78.94 APE8-rot-na 30.7 APE67-dihe-in -67.4, -20.31 -55.84, -33.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.9035 APE9-dist-in 7.112 None None None XRAY 2.3 0.195 0.228 A 290.0 264.0 9 31 27 4 [[370, 628]] 1.0 4xg4 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4XG6A P43405 363 635 635.0 X6G:60701 Type1 None DFGin 6.2537 14.3137 BLAminus -118.6, -179.8 61.85, 86.51 -104.68, 19.31 297.54, 90.69 -53.97, -29.58 in-in in 7.8485 Saltbr-in 2.6754 HRD-in -72.81, -51.23 73.7, 7.07 in-in-none SNCiin in-none ActLoopNT-in 2.9076 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -1.44 APE8-rot-na 30.73 APE67-dihe-in -63.62, -23.47 -57.96, -32.34 APE12-dist-na 11.5801 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.192 0.23 A 290.0 270.0 3 31 28 3 [[370, 628]] 1.0 4xg6 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4XG8C P43405 364 629 635.0 X8G:700 Type1 None DFGin 6.3686 14.2664 BLAminus -112.98, -178.28 65.43, 72.58 -97.08, 19.7 293.26, 93.71 -69.16, -21.23 in-in in 8.0447 Saltbr-in 2.925 HRD-in -74.14, -54.5 72.61, 6.51 in-in-none SNCiin in-none ActLoopNT-in 2.7094 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 27.72 APE8-rot-na 24.07 APE67-dihe-in -75.25, -15.23 -58.44, -32.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.249 0.275 C 290.0 254.0 12 31 26 5 [[370, 628]] 1.0 4xg8 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4XG9A P43405 363 632 635.0 X9G:700 Type1 None DFGin 6.3878 14.2532 BLAminus -123.44, -179.44 57.72, 74.85 -93.27, 25.8 301.09, 93.35 -61.2, -36.75 in-in in 7.9638 Saltbr-in 2.623 HRD-in -74.42, -57.7 72.94, 15.94 in-in-none SNCiin in-none ActLoopNT-in 2.7873 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 14.65 APE8-rot-na 19.29 APE67-dihe-in -69.72, -24.67 -61.87, -28.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.91 0.21 0.241 A 290.0 259.0 11 31 25 6 [[370, 628]] 1.0 4xg9 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4XG9B P43405 363 634 635.0 X9G:700 Type1 None DFGin 6.3472 14.2163 BLAminus -128.68, -177.25 53.27, 77.68 -95.83, 18.82 297.69, 92.87 -61.29, -26.93 in-in in 7.9683 Saltbr-in 2.5033 HRD-in -72.55, -56.82 71.48, 16.81 in-in-none SNCiin in-none ActLoopNT-in 2.8334 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 14.58 APE8-rot-na 27.68 APE67-dihe-in -67.7, -23.41 -54.17, -35.6 APE12-dist-na 11.89 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.91 0.21 0.241 B 290.0 265.0 7 31 28 3 [[370, 628]] 1.0 4xg9 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 5GHVA P43405 363 635 635.0 X5G:701 Type1 None DFGin 6.5102 14.4863 BLAminus -121.34, 177.94 62.19, 88.65 -109.69, 41.48 296.98, 84.28 -77.6, -32.83 in-in in 8.1098 Saltbr-in 2.7323 HRD-in -76.16, -59.71 78.21, 9.71 in-in-none SNCiin in-none ActLoopNT-in 2.9639 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 59.75 APE9-dihe-in -134.2, 142.35 APE8-dihe-in -78.13, 86.38 APE8-rot-na 29.33 APE67-dihe-in -64.76, -25.26 -61.51, -32.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.6682 APE9-dist-in 7.3984 None None None XRAY 2.8 0.217 0.227 A 290.0 265.0 8 31 27 4 [[370, 628]] 1.0 5ghv Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 5GHVB P43405 363 635 635.0 X5G:701 Type1 None DFGin 6.495 14.3903 BLAminus -125.29, 176.55 63.13, 89.9 -112.44, 39.0 296.07, 82.84 -75.29, -45.81 in-in in 8.0744 Saltbr-in 2.7148 HRD-in -75.16, -55.76 75.92, 10.79 in-in-none SNCiin in-none ActLoopNT-in 3.0942 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 48.46 APE9-dihe-in -133.95, 133.36 APE8-dihe-in -79.51, 91.82 APE8-rot-na 28.71 APE67-dihe-in -66.71, -23.44 -67.07, -29.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.251 APE9-dist-in 7.5687 None None None XRAY 2.8 0.217 0.227 B 290.0 265.0 8 31 27 4 [[370, 628]] 1.0 5ghv Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 8XQ0B P43405 364 634 635.0 A1LV4:701 Type1 None DFGin 6.2936 14.2694 BLAminus -121.56, -165.09 54.01, 77.14 -98.56, 23.24 296.48, 92.65 -61.88, -28.43 in-in in 8.4179 Saltbr-in 2.6489 HRD-in -77.64, -48.09 70.42, 13.58 in-in-none SNCiin in-none ActLoopNT-in 2.7959 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 110.46 APE9-dihe-in -140.12, 100.43 APE8-dihe-in -73.17, 75.7 APE8-rot-na 30.62 APE67-dihe-in -68.44, -13.24 -66.75, -26.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.655 APE9-dist-in 6.8754 None None None XRAY 1.95 0.222 0.265 B 290.0 253.0 18 31 27 4 [[370, 628]] 1.0 8xq0 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 8XQ0D P43405 364 635 635.0 A1LV4:701 Type1 None DFGin 6.3141 14.39 BLAminus -120.19, -170.79 65.2, 70.98 -95.79, 24.62 295.16, 93.42 -63.39, -28.44 in-in in 8.488 Saltbr-in 2.7009 HRD-in -76.01, -49.61 70.34, 8.1 in-in-none SNCiin in-none ActLoopNT-in 2.7872 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 140.86 APE9-dihe-in -154.41, 100.57 APE8-dihe-in -72.25, 67.88 APE8-rot-na 28.73 APE67-dihe-in -63.58, -17.28 -53.94, -36.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.1642 APE9-dist-in 6.9631 None None None XRAY 1.95 0.222 0.265 D 290.0 258.0 14 31 27 4 [[370, 628]] 1.0 8xq0 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 8XQ1A P43405 364 634 635.0 A1LV6:901 Type1 None DFGin 6.3005 14.4821 BLAminus -124.74, -173.52 66.63, 71.35 -96.63, 19.35 289.84, 89.05 -66.02, -25.46 in-in in 8.2664 Saltbr-in 2.8165 HRD-in -80.15, -50.35 70.61, 8.83 in-in-none SNCiin in-none ActLoopNT-in 2.9599 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 134.1 APE9-dihe-in -110.96, 150.88 APE8-dihe-in -81.12, 69.26 APE8-rot-na 30.82 APE67-dihe-in -65.34, -12.5 -60.05, -31.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.5951 APE9-dist-in 7.0861 None None None XRAY 1.5 0.188 0.209 A 290.0 263.0 8 31 28 3 [[370, 628]] 1.0 8xq1 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 8XQ1B P43405 364 634 635.0 A1LV6:901 Type1 None DFGin 6.3063 14.4383 BLAminus -122.4, -173.86 66.54, 73.25 -99.1, 21.97 289.94, 89.92 -65.7, -26.72 in-in in 8.2054 Saltbr-in 2.8276 HRD-in -76.67, -51.02 71.1, 10.17 in-in-none SNCiin in-none ActLoopNT-in 2.9809 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 119.35 APE9-dihe-in -109.54, 149.84 APE8-dihe-in -80.64, 68.82 APE8-rot-na 32.7 APE67-dihe-in -66.82, -12.34 -64.74, -24.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.3635 APE9-dist-in 7.1118 None None None XRAY 1.5 0.188 0.209 B 290.0 263.0 8 31 28 3 [[370, 628]] 1.0 8xq1 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 8XQ2A P43405 363 634 635.0 A1LV7:802 Type1 None DFGin 6.3658 14.4252 BLAminus -126.78, -178.48 65.06, 70.63 -92.55, 21.67 293.19, 85.55 -66.06, -22.05 in-in in 8.3413 Saltbr-in 2.8288 HRD-in -77.37, -51.66 73.37, 4.48 in-in-none SNCiin in-none ActLoopNT-in 2.9034 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 83.79 APE8-rot-na 27.63 APE67-dihe-in -66.2, -13.18 -59.95, -35.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.206 0.238 A 290.0 263.0 9 31 27 4 [[370, 628]] 1.0 8xq2 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 8XQ2B P43405 364 632 635.0 A1LV7:701 Type1 None DFGin 6.4068 14.5701 BLAminus -126.32, -176.03 64.56, 73.36 -94.65, 19.7 292.4, 83.49 -62.95, -22.08 in-in in 8.2828 Saltbr-in 2.9205 HRD-in -78.79, -49.2 70.93, 7.72 in-in-none SNCiin in-none ActLoopNT-in 2.9523 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 81.5 APE9-dihe-in -124.35, 129.64 APE8-dihe-in -71.15, 79.1 APE8-rot-na 29.02 APE67-dihe-in -66.5, -10.69 -61.42, -32.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.7504 APE9-dist-in 6.8398 None None None XRAY 1.8 0.206 0.238 B 290.0 261.0 8 31 29 2 [[370, 628]] 1.0 8xq2 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 1XBBA P43405 363 635 635.0 STI:60001 Type1 None DFGin 6.6637 14.623 BLAminus -128.05, 176.75 68.38, 79.08 -100.61, 19.15 290.6, 90.35 -58.48, -28.27 in-in in 8.2357 Saltbr-in 3.0323 HRD-in -76.13, -51.62 74.69, 4.56 in-in-none SNCiin in-none ActLoopNT-in 2.8779 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 178.76 APE9-dihe-in -111.48, 137.0 APE8-dihe-in -74.08, 70.57 APE8-rot-na 29.87 APE67-dihe-in -65.65, -14.73 -52.2, -36.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.1255 APE9-dist-in 7.1998 None None None XRAY 1.57 0.191 0.221 A 291.0 264.0 9 31 27 4 [[370, 628]] 1.0 1xbb Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 3FQEA P43405 363 635 635.0 P5C:60001 Type1 None DFGin 6.2412 14.5522 BLAminus -134.09, -160.32 61.99, 71.61 -98.66, 22.24 289.6, 83.21 -60.61, -25.52 in-in in 8.2494 Saltbr-in 3.3621 HRD-in -87.09, -50.31 69.38, 7.86 in-in-none SNCiin in-none ActLoopNT-in 2.9525 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 126.45 APE9-dihe-in -122.15, 142.06 APE8-dihe-in -70.06, 69.94 APE8-rot-na 27.41 APE67-dihe-in -70.93, -8.12 -53.23, -38.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.2122 APE9-dist-in 7.0719 None None None XRAY 2.5 0.203 0.253 A 291.0 265.0 8 31 28 3 [[370, 628]] 1.0 3fqe Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 3FQHB P43405 363 633 635.0 057:2 Type1 None DFGin 6.5124 14.384 BLAminus -135.61, -177.0 61.05, 83.05 -100.81, 28.19 289.97, 93.91 -68.13, -27.21 in-in in 7.9505 Saltbr-in 2.9286 HRD-in -70.78, -57.98 73.35, 4.27 in-in-none SNCiin in-none ActLoopNT-in 2.9456 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 140.44 APE9-dihe-in -122.67, 149.45 APE8-dihe-in -71.04, 64.02 APE8-rot-na 27.55 APE67-dihe-in -70.95, -10.14 -42.56, -38.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.9315 APE9-dist-in 7.0578 None None None XRAY 2.26 0.216 0.259 B 291.0 258.0 13 31 27 4 [[370, 628]] 1.0 3fqh Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 3FQSA P43405 363 635 635.0 585:60001 Type1 None DFGin 6.6713 15.1191 BLAminus -130.1, -168.06 51.07, 81.04 -99.05, 21.72 287.94, 89.19 -65.06, -25.56 in-in in 8.2508 Saltbr-in 2.8899 HRD-in -73.57, -53.38 73.0, 6.23 in-in-none SNCiin in-none ActLoopNT-in 2.927 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 124.94 APE9-dihe-in -106.74, 133.78 APE8-dihe-in -71.17, 66.53 APE8-rot-na 27.84 APE67-dihe-in -63.27, -16.28 -46.11, -40.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.7157 APE9-dist-in 7.4905 None None None XRAY 2.1 0.218 0.253 A 291.0 264.0 9 31 27 4 [[370, 628]] 1.0 3fqs Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4FYNA P43405 363 635 635.0 0VE:60701 Type1 None DFGin 6.3219 14.5516 BLAminus -125.05, -173.65 56.58, 84.17 -104.44, 22.0 295.83, 84.03 -64.28, -16.7 in-in in 8.1681 Saltbr-in 2.7467 HRD-in -77.65, -54.89 74.1, 7.86 in-in-none SNCiin in-none ActLoopNT-in 2.9237 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 150.74 APE9-dihe-in -119.38, 130.75 APE8-dihe-in -71.21, 75.44 APE8-rot-na 25.91 APE67-dihe-in -62.88, -14.32 -62.84, -38.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.7508 APE9-dist-in 7.3399 None None None XRAY 2.318 0.228 0.269 A 291.0 263.0 10 31 27 4 [[370, 628]] 1.0 4fyn Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4FYOA P43405 363 635 635.0 0VF:60701 Type1 None DFGin 6.5272 14.6759 BLAminus -132.65, -177.95 62.23, 72.42 -93.99, 21.12 289.45, 90.18 -61.07, -25.58 in-in in 7.7502 Saltbr-in 2.757 HRD-in -74.26, -50.97 72.76, 4.05 in-in-none SNCiin in-none ActLoopNT-in 2.9524 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 140.05 APE9-dihe-in -108.11, 144.2 APE8-dihe-in -76.07, 73.27 APE8-rot-na 27.85 APE67-dihe-in -65.29, -14.44 -52.41, -38.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.9467 APE9-dist-in 7.3079 None None None XRAY 1.4 0.22 0.24 A 291.0 263.0 10 31 27 4 [[370, 628]] 1.0 4fyo Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4FZ6A P43405 363 635 635.0 0VG:60701 Type1 None DFGin 6.3168 14.6915 BLAminus -133.65, -169.74 58.51, 78.15 -100.44, 26.78 291.45, 90.91 -64.04, -31.24 in-in in 8.4426 Saltbr-in 3.0064 HRD-in -75.46, -52.97 71.45, 4.73 in-in-none SNCiin in-none ActLoopNT-in 2.9013 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 139.2 APE9-dihe-in -115.79, 143.14 APE8-dihe-in -76.09, 69.74 APE8-rot-na 28.85 APE67-dihe-in -66.47, -14.43 -53.02, -38.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.4665 APE9-dist-in 7.234 None None None XRAY 1.85 0.23 0.253 A 291.0 262.0 11 31 27 4 [[370, 628]] 1.0 4fz6 Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4FZ7A P43405 363 635 635.0 0VH:60701 Type1 None DFGin 6.4003 14.4126 BLAminus -130.24, -170.94 63.54, 68.16 -91.78, 16.19 289.77, 87.77 -59.49, -25.0 in-in in 8.2193 Saltbr-in 2.9497 HRD-in -74.99, -52.16 71.67, 6.11 in-in-none SNCiin in-none ActLoopNT-in 2.8772 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 93.82 APE9-dihe-in -107.75, 152.66 APE8-dihe-in -78.57, 65.92 APE8-rot-na 31.11 APE67-dihe-in -66.21, -17.27 -45.73, -35.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.6065 APE9-dist-in 6.9009 None None None XRAY 1.75 0.202 0.25 A 291.0 261.0 12 31 27 4 [[370, 628]] 1.0 4fz7 Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4I0RA P43405 363 635 635.0 1B4:60701 Type1 None DFGin 6.3034 14.4722 BLAminus -120.7, -175.74 66.13, 76.03 -99.52, 27.66 293.49, 90.9 -68.19, -27.87 in-in in 8.0785 Saltbr-in 2.7945 HRD-in -77.52, -55.13 72.71, 3.63 in-in-none SNCiin in-none ActLoopNT-in 2.8563 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 132.26 APE9-dihe-in -103.47, 139.74 APE8-dihe-in -70.94, 75.19 APE8-rot-na 28.76 APE67-dihe-in -61.34, -17.47 -59.11, -38.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.7267 APE9-dist-in 7.1578 None None None XRAY 2.1 0.237 0.272 A 291.0 260.0 13 31 27 4 [[370, 628]] 1.0 4i0r Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4I0SA P43405 363 635 635.0 1B5:60701 Type1 None DFGin 6.3483 14.3184 BLAminus -129.27, -175.27 55.43, 83.6 -98.08, 24.19 289.58, 86.12 -61.12, -27.32 in-in in 8.0335 Saltbr-in 2.5894 HRD-in -71.15, -52.29 70.43, 7.1 in-in-none SNCiin in-none ActLoopNT-in 2.9258 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 126.23 APE9-dihe-in -113.12, 145.51 APE8-dihe-in -74.21, 66.56 APE8-rot-na 27.25 APE67-dihe-in -64.4, -15.49 -48.66, -38.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.6732 APE9-dist-in 7.2386 None None None XRAY 1.98 0.218 0.236 A 291.0 263.0 10 31 27 4 [[370, 628]] 1.0 4i0s Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4PUZA P43405 363 633 635.0 CG9:701 Type1 None DFGin 6.3668 14.2903 BLAminus -136.54, -176.83 63.98, 77.0 -97.69, 30.02 296.24, 87.49 -65.1, -31.87 in-in in 7.9295 Saltbr-in 2.8225 HRD-in -73.68, -57.13 77.44, 4.88 in-in-none SNCiin in-none ActLoopNT-in 2.806 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 106.61 APE9-dihe-in -123.49, 140.78 APE8-dihe-in -68.55, 53.64 APE8-rot-na 28.04 APE67-dihe-in -67.84, -11.38 -28.81, -44.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.9145 APE9-dist-in 7.237 None None None XRAY 2.085 0.213 0.261 A 291.0 263.0 8 31 28 3 [[370, 628]] 1.0 4puz Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4PUZB P43405 363 635 635.0 CG9:701 Type1 None DFGin 6.3028 14.2734 BLAminus -130.49, 178.11 63.06, 88.54 -109.96, 27.3 298.33, 92.7 -70.91, -20.76 in-in in 7.8147 Saltbr-in 2.9053 HRD-in -68.83, -56.51 73.59, 10.98 in-in-none SNCiin in-none ActLoopNT-in 2.6785 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 100.98 APE9-dihe-in -104.75, 136.54 APE8-dihe-in -73.52, 61.27 APE8-rot-na 28.37 APE67-dihe-in -69.59, -18.44 -38.04, -42.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.4136 APE9-dist-in 6.9757 None None None XRAY 2.085 0.213 0.261 B 291.0 265.0 8 31 28 3 [[370, 628]] 1.0 4puz Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 5T68A P43405 363 635 635.0 77V:60701 Type1 None DFGin 6.3993 14.2326 BLAminus -118.2, -175.03 55.02, 90.22 -105.11, 31.93 294.35, 102.52 -80.93, -22.27 in-in in 7.8644 Saltbr-in 2.7665 HRD-in -79.38, -47.76 69.54, -3.58 in-in-none SNCiin in-none ActLoopNT-in 3.07 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -53.8 APE9-dihe-in -121.95, 75.31 APE8-dihe-in -77.88, 51.45 APE8-rot-na 19.76 APE67-dihe-in -78.2, -26.54 -39.48, -21.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.2909 APE9-dist-in 7.5867 None None None XRAY 2.93 0.188 0.281 A 291.0 264.0 9 31 27 4 [[370, 628]] 1.0 5t68 Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 5T68B P43405 363 635 635.0 77V:60701 Type1 None DFGin 6.3354 14.5494 BLAminus -125.81, -173.18 53.62, 72.36 -90.46, 31.38 289.78, 97.36 -69.64, -47.12 in-in in 7.8586 Saltbr-in 2.7952 HRD-in -56.8, -40.48 64.3, -8.06 in-in-none SNCiin in-none ActLoopNT-in 2.9962 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -66.53 APE9-dihe-in -122.76, 73.0 APE8-dihe-in -76.02, 70.05 APE8-rot-na 29.83 APE67-dihe-in -58.48, -8.81 -36.73, -49.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.2436 APE9-dist-in 6.8603 None None None XRAY 2.93 0.188 0.281 B 291.0 264.0 9 31 27 4 [[370, 628]] 1.0 5t68 Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 5Y5UB P43405 363 629 635.0 8OU:701 Type1 None DFGin 6.3221 13.9991 BLAminus -136.83, 172.48 60.12, 69.06 -76.3, 17.06 301.14, 79.7 -45.71, -46.86 in-in in 7.647 Saltbr-in 2.7979 HRD-in -72.89, -51.34 74.65, -2.0 in-in-none SNCiin in-none ActLoopNT-in 2.8215 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 45.91 APE8-rot-na 27.44 APE67-dihe-in -59.42, -23.8 -55.69, -38.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.14 0.239 0.26 B 293.0 257.0 10 31 25 6 [[370, 628]] 1.0 5y5u Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 8WYWA P43405 364 633 635.0 XFB:701 Type1 None DFGin 6.2371 14.4668 BLAminus -132.59, -164.71 66.23, 68.08 -96.88, 23.52 293.79, 90.86 -58.6, -30.92 in-in in 8.0458 Saltbr-in 2.7999 HRD-in -78.12, -54.08 75.86, 6.55 in-in-none SNCiin in-none ActLoopNT-in 2.953 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 61.34 APE8-rot-na 31.52 APE67-dihe-in -65.01, -13.06 -58.71, -34.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.202 0.242 A 293.0 264.0 6 31 25 6 [[370, 628]] 1.0 8wyw Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 8WYWB P43405 365 633 635.0 XFB:701 Type1 None DFGin 6.298 14.4316 BLAminus -136.18, -166.23 64.92, 68.41 -94.85, 24.26 293.81, 88.05 -62.54, -27.54 in-in in 8.0999 Saltbr-in 2.7616 HRD-in -75.21, -53.42 72.9, 5.68 in-in-none SNCiin in-none ActLoopNT-in 2.9696 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 56.28 APE8-rot-na 30.56 APE67-dihe-in -70.56, -10.12 -50.08, -35.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.202 0.242 B 293.0 263.0 6 31 25 6 [[370, 628]] 1.0 8wyw Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 3VF8A P43405 363 635 635.0 0JE:701 Type1 None DFGin 6.3028 14.2743 BLAminus -127.47, -170.59 55.16, 83.49 -101.53, 21.98 288.96, 89.41 -58.75, -35.76 in-none in 8.0426 Saltbr-none 999.0 HRD-in -73.27, -51.41 67.21, 6.99 none-in-in SNCnii in-in ActLoopNT-in 2.9847 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.14, 90.57 APE9-dihe-in -105.62, 138.03 APE8-dihe-in -81.27, 73.81 APE8-rot-na 26.23 APE67-dihe-in -66.47, -16.98 -51.38, -34.52 APE12-dist-na 13.2571 APE11-dist-na 10.0917 APE10-dist-na 10.0065 APE9-dist-in 6.7963 None None None XRAY 2.08 0.217 0.241 A 299.0 265.0 8 31 31 0 [[370, 628]] 1.0 3vf8 Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 3VF9A P43405 364 635 635.0 477:701 Type1 None DFGin 6.3963 14.6399 BLAminus -128.07, -174.94 57.37, 81.54 -100.98, 31.05 291.59, 91.29 -68.94, -37.68 in-none in 7.996 Saltbr-none 999.0 HRD-in -72.91, -49.87 65.85, 9.08 none-in-in SNCnii in-in ActLoopNT-in 3.0228 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.57, 94.78 APE9-dihe-in -116.96, 141.01 APE8-dihe-in -83.94, 81.53 APE8-rot-na 20.28 APE67-dihe-in -58.58, -19.75 -44.92, -48.84 APE12-dist-na 13.2066 APE11-dist-na 10.5082 APE10-dist-na 9.8773 APE9-dist-in 6.6964 None None None XRAY 2.3 0.255 0.267 A 299.0 265.0 7 31 31 0 [[370, 628]] 1.0 3vf9 Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 6SSBA P43405 363 635 635.0 LUE:60701 Type1 None DFGin 6.5917 14.4675 BLAminus -122.14, -172.72 60.63, 82.61 -104.23, 21.05 289.2, 91.73 -65.13, -29.21 in-in in 8.3222 Saltbr-in 2.9383 HRD-in -79.93, -48.97 63.18, 12.69 in-in-none SNCiin in-none ActLoopNT-in 2.8303 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 141.28 APE9-dihe-in -123.27, 130.6 APE8-dihe-in -78.29, 70.91 APE8-rot-na 28.49 APE67-dihe-in -60.55, -20.65 -51.68, -36.02 APE12-dist-na 13.3546 APE11-dist-na 999.0 APE10-dist-na 11.696 APE9-dist-in 7.5985 None None None XRAY 2.08 0.198 0.225 A 299.0 265.0 8 31 30 1 [[370, 628]] 1.0 6ssb Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 6ZCQA P43405 363 635 635.0 QFB:60701 Type1 None DFGin 6.2843 14.2005 BLAminus -124.06, -169.43 66.04, 72.78 -96.7, 17.81 287.27, 83.52 -60.89, -32.14 in-in in 7.9918 Saltbr-in 2.9869 HRD-in -74.82, -45.46 62.85, 5.49 in-in-none SNCiin in-none ActLoopNT-in 2.7856 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 48.57 APE9-dihe-in -117.91, 130.07 APE8-dihe-in -75.75, 81.23 APE8-rot-na 23.59 APE67-dihe-in -67.53, -16.63 -56.17, -31.85 APE12-dist-na 13.3427 APE11-dist-na 999.0 APE10-dist-na 10.6629 APE9-dist-in 7.588 None None None XRAY 2.32 0.191 0.244 A 299.0 265.0 8 31 30 1 [[370, 628]] 1.0 6zcq Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 6ZCRA P43405 363 635 635.0 5JG:60701 Type1 None DFGin 6.6911 14.6157 BLAminus -131.25, -174.99 58.52, 82.29 -98.4, 23.45 287.56, 81.54 -60.43, -25.78 in-in in 8.0047 Saltbr-in 2.9213 HRD-in -78.76, -53.73 70.25, 7.39 in-in-none SNCiin in-none ActLoopNT-in 2.8035 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.61 APE8-dihe-in -81.67, 70.3 APE8-rot-na 33.8 APE67-dihe-in -65.02, -14.57 -49.04, -40.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.7148 None None None XRAY 1.73 0.189 0.218 A 299.0 264.0 9 31 27 4 [[370, 628]] 1.0 6zcr Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 6ZCSA P43405 363 635 635.0 QFE:60701 Type1 None DFGin 6.4231 14.5156 BLAminus -134.38, -165.15 61.58, 75.97 -101.01, 19.73 286.51, 84.39 -60.24, -29.14 in-in in 8.0858 Saltbr-in 2.9668 HRD-in -75.9, -52.9 70.28, 10.24 in-in-none SNCiin in-none ActLoopNT-in 2.9526 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 129.22 APE9-dihe-in -113.36, 141.08 APE8-dihe-in -78.2, 72.25 APE8-rot-na 29.63 APE67-dihe-in -66.52, -13.86 -50.21, -39.33 APE12-dist-na 13.3749 APE11-dist-na 999.0 APE10-dist-na 11.3069 APE9-dist-in 7.0916 None None None XRAY 1.47 0.191 0.208 A 299.0 267.0 6 31 30 1 [[370, 628]] 1.0 6zcs Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 6ZCUA P43405 363 635 635.0 5JG:60701 Type1 None DFGin 6.6911 14.6157 BLAminus -131.25, -174.99 58.52, 82.29 -98.4, 23.45 287.56, 81.54 -60.43, -25.78 in-in in 8.0047 Saltbr-in 2.9213 HRD-in -78.76, -53.73 70.25, 7.39 in-in-none SNCiin in-none ActLoopNT-in 2.8035 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.61 APE8-dihe-in -81.67, 70.3 APE8-rot-na 33.8 APE67-dihe-in -65.02, -14.57 -49.04, -40.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.7148 None None None XRAY 1.73 0.189 0.218 A 299.0 264.0 9 31 27 4 [[370, 628]] 1.0 6zcu Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 6ZCXA P43405 363 635 635.0 QFQ:60701 Type1 None DFGin 6.3945 14.216 BLAminus -127.67, -173.55 62.06, 69.93 -92.28, 16.27 287.89, 90.74 -57.86, -30.2 in-in in 7.9808 Saltbr-in 2.76 HRD-in -77.57, -48.61 68.8, 7.96 in-in-none SNCiin in-none ActLoopNT-in 2.8651 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 153.3 APE9-dihe-in -109.71, 136.91 APE8-dihe-in -79.72, 69.78 APE8-rot-na 28.01 APE67-dihe-in -63.91, -15.97 -45.91, -39.08 APE12-dist-na 13.3538 APE11-dist-na 999.0 APE10-dist-na 11.597 APE9-dist-in 7.1674 None None None XRAY 1.66 0.191 0.229 A 299.0 263.0 10 31 30 1 [[370, 628]] 1.0 6zcx Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 6ZCYA P43405 363 635 635.0 QF8:60701 Type1 None DFGin 6.3873 14.1917 BLAminus -129.73, -170.79 60.52, 70.48 -91.88, 15.3 287.22, 87.41 -58.42, -30.07 in-in in 7.9303 Saltbr-in 2.7679 HRD-in -74.39, -48.85 68.77, 6.76 in-in-none SNCiin in-none ActLoopNT-in 2.961 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 129.7 APE9-dihe-in -121.42, 129.82 APE8-dihe-in -80.2, 74.63 APE8-rot-na 27.78 APE67-dihe-in -63.99, -16.94 -49.51, -37.22 APE12-dist-na 13.9777 APE11-dist-na 999.0 APE10-dist-na 10.3668 APE9-dist-in 7.055 None None None XRAY 1.81 0.19 0.223 A 299.0 263.0 10 31 30 1 [[370, 628]] 1.0 6zcy Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 8BI2A P43405 363 635 635.0 QR7:60701 Type1 None DFGin 6.3914 14.3495 BLAminus -125.08, -171.04 64.92, 73.8 -98.47, 21.21 291.51, 90.98 -64.58, -29.05 in-in in 8.1756 Saltbr-in 2.8892 HRD-in -78.14, -51.69 70.22, 11.64 in-in-none SNCiin in-none ActLoopNT-in 2.9048 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 81.28 APE9-dihe-in -115.01, 139.63 APE8-dihe-in -80.07, 71.09 APE8-rot-na 29.24 APE67-dihe-in -64.38, -13.13 -46.76, -40.63 APE12-dist-na 12.7009 APE11-dist-na 999.0 APE10-dist-na 9.9378 APE9-dist-in 7.0069 None None None XRAY 1.508 0.205 0.235 A 299.0 264.0 9 31 30 1 [[370, 628]] 1.0 8bi2 Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 5CXZA P43405 363 635 635.0 55U:60703 Type1 None DFGin 6.5387 14.3651 BLAminus -122.74, -171.85 60.83, 74.48 -94.07, 15.61 289.21, 94.41 -56.97, -30.72 in-in in 7.9532 Saltbr-in 2.8179 HRD-in -72.21, -54.6 71.31, 11.0 in-in-none SNCiin in-none ActLoopNT-in 2.9944 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 104.14 APE9-dihe-in -107.14, 142.58 APE8-dihe-in -80.12, 71.68 APE8-rot-na 30.9 APE67-dihe-in -65.83, -15.68 -54.56, -35.41 APE12-dist-na 13.5088 APE11-dist-na 999.0 APE10-dist-na 11.3489 APE9-dist-in 7.1319 K467T None None XRAY 1.7 0.195 0.208 A 289.0 267.0 6 31 30 1 [[370, 628]] 1.0 5cxz Homo sapiens TYR_SYK_HUMAN TYR 3.9e-90 307.6 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
SYK KSYK_HUMAN 4PX6A P43405 364 635 635.0 2X6:60701 Type1 None DFGin 6.5961 14.5568 BLAminus -133.62, -172.86 59.0, 67.69 -88.07, 18.86 287.15, 91.9 -59.4, -27.39 in-in in 7.764 Saltbr-in 2.8025 HRD-in -78.31, -51.2 71.98, 5.54 in-in-none SNCiin in-none ActLoopNT-in 2.9336 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 131.68 APE9-dihe-in -102.64, 145.76 APE8-dihe-in -78.83, 69.49 APE8-rot-na 28.48 APE67-dihe-in -64.5, -16.03 -45.05, -41.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.9576 APE9-dist-in 7.3534 K467T None None XRAY 1.6 0.176 0.202 A 291.0 261.0 11 31 27 4 [[370, 628]] 1.0 4px6 Homo sapiens TYR_SYK_HUMAN TYR 4e-90 307.6 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK

TYR_SYK (Tyrosine-protein kinase SYK)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name