TKL_RAF1 (RAF proto-oncogene serine/threonine-protein kinase)

Total number of chains: 32
Active chains: 2
Uniprot: RAF1_HUMAN
Kinase Domain Residues: 349 - 608
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 11 34.4% AF-P04049-K1A
DFGin BLBplus 7 21.9% 9MMQA
DFGin None 5 15.6% 8CHFA
None None 5 15.6% 8GAED
DFGin BLAplus 2 6.2% 9O0VE
DFGin BLBminus 2 6.2% 9O0UC

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
RAF1 AF-P04049-K1A P04049 341 616 648.0 No_ligand No_ligand Active DFGin 6.5203 13.7817 BLAminus -132.07, -167.34 50.52, 81.79 -93.0, 17.5 287.63, 84.75 -60.82, -26.68 in-in in 8.771 Saltbr-in 2.7908 HRD-in -75.2, -41.77 65.71, -17.78 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -82.32, 124.86 APE9-dihe-na 150.0, -177.65 APE8-dihe-in -88.86, 110.11 APE8-rot-in 297.22 APE67-dihe-in -59.64, -29.86 -48.29, -38.25 APE12-dist-in 13.3725 APE11-dist-in 11.5758 APE10-dist-in 7.2465 APE9-dist-in 5.6357 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 30 30 0 [[349, 608]] 1.0 AF-P04049-K1 TKL_RAF1_HUMAN TKL 2.5e-81 279.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 AF-P04049-K3A P04049 341 616 648.0 No_ligand No_ligand Active DFGin 6.6956 13.8203 BLAminus -127.79, -164.94 51.29, 73.3 -87.25, 15.65 292.37, 90.99 -61.36, -23.57 in-in in 9.3042 Saltbr-in 2.9127 HRD-in -75.32, -37.72 66.17, -19.03 in-in-in SNCiii in-in ActLoopNT-in 2.9047 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.73, 136.21 APE9-dihe-na 118.54, -171.69 APE8-dihe-in -96.47, 111.5 APE8-rot-in 306.19 APE67-dihe-in -65.71, -24.96 -56.51, -31.57 APE12-dist-in 12.8315 APE11-dist-in 12.1084 APE10-dist-in 6.6368 APE9-dist-in 4.1332 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 30 30 0 [[349, 608]] 1.0 AF-P04049-K3 TKL_RAF1_HUMAN TKL 2.5e-81 279.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9AYAA P04049 342 614 648.0 No_ligand No_ligand Inactive DFGin 6.3662 14.2668 BLAminus -136.12, -165.85 49.32, 86.99 -103.48, 21.74 291.83, 76.13 -59.74, -18.47 in-none in 9.0808 Saltbr-none 999.0 HRD-in -71.73, -48.54 69.99, 0.7 none-in-out SNCnio in-out ActLoopNT-in 2.8942 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -128.07, 13.13 APE9-dihe-na -91.19, -175.11 APE8-dihe-in -69.87, 137.88 APE8-rot-in 300.15 APE67-dihe-in -63.77, -25.92 -71.38, -32.74 APE12-dist-in 12.5452 APE11-dist-in 9.8883 APE10-dist-out 8.8439 APE9-dist-in 5.9778 Y340D,Y341D None None XRAY 2.59 0.214 0.257 A 280.0 267.0 6 30 30 0 [[349, 608]] 1.0 9aya TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9AYAC P04049 341 613 648.0 No_ligand No_ligand Inactive DFGin 6.5551 14.821 BLAminus -133.94, -166.68 54.0, 73.37 -92.76, 23.95 288.97, 82.99 -61.86, -28.32 in-in in 8.7648 Saltbr-in 2.8037 HRD-in -69.13, -44.61 68.35, -7.89 in-in-out SNCiio in-out ActLoopNT-in 2.8119 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 53.27, 27.21 APE9-dihe-na -96.24, -140.6 APE8-dihe-in -94.61, 133.74 APE8-rot-out 177.74 APE67-dihe-in -62.64, -31.47 -74.96, -14.97 APE12-dist-in 12.0325 APE11-dist-in 8.2808 APE10-dist-out 10.5493 APE9-dist-out 7.7979 Y340D,Y341D None None XRAY 2.59 0.214 0.257 C 280.0 263.0 10 30 30 0 [[349, 608]] 1.0 9aya TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9AXAA P04049 342 625 648.0 No_ligand No_ligand Inactive DFGin 7.2548 13.9989 BLAminus -139.05, -163.7 58.24, 64.96 -89.4, 29.46 290.36, 82.23 -69.56, -16.76 in-out in 9.18 Saltbr-out 8.4188 HRD-in -78.78, -32.03 70.97, -14.05 out-in-out SNCoio in-out ActLoopNT-in 3.116 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -130.3, -20.74 APE9-dihe-na -70.73, -178.58 APE8-dihe-in -67.69, 139.48 APE8-rot-in 293.88 APE67-dihe-in -69.75, -43.45 -74.78, -4.77 APE12-dist-in 12.0486 APE11-dist-in 9.617 APE10-dist-out 9.0441 APE9-dist-out 7.5911 Y340D,Y341D SEP621 SEP621 EM 4.36 999.0 999.0 A 563.0 273.0 11 30 25 5 [[349, 608]] 1.0 9axa TKL_RAF1_HUMAN TKL 2.2e-80 276.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9AXAC P04049 341 625 648.0 No_ligand No_ligand Inactive DFGin 7.3924 14.9903 BLAminus -146.66, -157.9 56.49, 63.39 -91.79, 31.37 293.16, 80.76 -67.87, -25.57 in-out in 8.9755 Saltbr-out 10.0011 HRD-in -78.03, -41.77 71.76, -11.87 out-in-out SNCoio in-out ActLoopNT-in 2.7588 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 54.52, 48.67 APE9-dihe-na -119.18, -141.08 APE8-dihe-in -96.15, 129.35 APE8-rot-out 174.93 APE67-dihe-in -72.88, -14.72 -74.49, -3.91 APE12-dist-in 11.8542 APE11-dist-in 9.1816 APE10-dist-out 11.2816 APE9-dist-out 9.0508 Y340D,Y341D SEP621 SEP621 EM 4.36 999.0 999.0 C 563.0 275.0 10 30 30 0 [[349, 608]] 1.0 9axa TKL_RAF1_HUMAN TKL 2.2e-80 276.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9AXCA P04049 342 614 648.0 No_ligand No_ligand Inactive DFGin 7.1921 14.4156 BLAminus -138.33, -166.81 57.53, 66.49 -89.8, 33.05 291.57, 76.32 -64.02, -29.91 in-out in 9.5136 Saltbr-out 7.6297 HRD-in -72.6, -42.02 72.95, -10.85 out-in-out SNCoio in-out ActLoopNT-in 3.1646 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -134.52, -16.63 APE9-dihe-na -73.85, -175.48 APE8-dihe-in -71.62, 149.24 APE8-rot-in 297.36 APE67-dihe-in -71.32, -46.0 -82.78, -6.02 APE12-dist-in 12.2652 APE11-dist-in 10.7655 APE10-dist-out 9.0117 APE9-dist-out 7.1409 Y340D,Y341D None None EM 4.16 999.0 999.0 A 563.0 262.0 11 30 25 5 [[349, 608]] 1.0 9axc TKL_RAF1_HUMAN TKL 2.2e-80 276.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9AXCC P04049 341 614 648.0 No_ligand No_ligand Inactive DFGin 7.0993 14.2941 BLAminus -140.87, -159.63 58.35, 65.16 -89.93, 32.3 288.78, 78.02 -61.68, -35.06 in-out in 8.1468 Saltbr-out 3.9477 HRD-in -77.54, -28.87 66.49, -1.91 out-in-out SNCoio in-out ActLoopNT-in 2.6755 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 42.59, 31.87 APE9-dihe-na -96.68, -133.02 APE8-dihe-in -109.92, 127.09 APE8-rot-out 177.26 APE67-dihe-in -75.55, -23.65 -73.76, -3.99 APE12-dist-in 11.8637 APE11-dist-in 8.5952 APE10-dist-out 11.1083 APE9-dist-out 8.7613 Y340D,Y341D None None EM 4.16 999.0 999.0 C 563.0 264.0 10 30 30 0 [[349, 608]] 1.0 9axc TKL_RAF1_HUMAN TKL 2.2e-80 276.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9O0UG P04049 341 614 648.0 324:701 Type1 Inactive DFGin 6.6427 14.5362 BLAminus -137.03, -164.72 64.05, 59.07 -91.31, 23.03 298.27, 111.42 -70.02, -22.85 in-in in 8.466 Saltbr-in 2.7929 HRD-in -67.69, -46.18 73.87, -6.26 in-in-out SNCiio in-out ActLoopNT-in 3.4083 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -147.61, -172.9 APE9-dihe-na 96.11, -111.47 APE8-dihe-in -121.52, 159.07 APE8-rot-out 179.33 APE67-dihe-in -61.77, -27.13 -108.62, -7.48 APE12-dist-in 9.3284 APE11-dist-in 9.0351 APE10-dist-out 10.4777 APE9-dist-out 9.744 Y340D,Y341D None None XRAY 2.91 0.232 0.264 G 280.0 265.0 9 30 21 9 [[349, 608]] 1.0 9o0u TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9O0VG P04049 341 614 648.0 324:701 Type1 Inactive DFGin 6.6518 14.5256 BLAminus -136.91, -164.75 63.88, 58.79 -91.51, 23.22 298.64, 111.76 -69.75, -22.63 in-in in 8.5288 Saltbr-in 2.8267 HRD-in -68.13, -46.19 73.7, -5.88 in-in-out SNCiio in-out ActLoopNT-in 3.3624 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -144.93, -171.41 APE9-dihe-na 95.72, -110.34 APE8-dihe-in -121.89, 159.4 APE8-rot-out 179.42 APE67-dihe-in -62.17, -27.08 -108.22, -7.65 APE12-dist-in 9.3788 APE11-dist-in 8.988 APE10-dist-out 10.4038 APE9-dist-out 9.6609 Y340D,Y341D None None XRAY 3.5 0.208 0.254 G 280.0 265.0 9 30 21 9 [[349, 608]] 1.0 9o0v TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 3OMVB P04049 340 615 648.0 SM5:2 Type1 Inactive DFGin 6.2314 14.1198 BLAminus -128.39, -171.12 47.91, 84.95 -94.99, 35.62 285.33, 59.46 -60.18, -20.41 in-in in 8.4734 Saltbr-in 2.9066 HRD-in -95.5, -25.99 55.76, -81.98 in-in-out SNCiio in-out ActLoopNT-in 3.4203 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nooo APE10-dihe-na -64.38, 160.65 APE9-dihe-na -138.85, -166.53 APE8-dihe-in -147.75, 73.1 APE8-rot-out 58.68 APE67-dihe-out 164.31, -56.84 -70.36, 119.54 APE12-dist-none 999.0 APE11-dist-out 14.3402 APE10-dist-out 13.4894 APE9-dist-out 10.3958 None None None XRAY 4.0 0.283 0.364 B 307.0 264.0 12 30 18 12 [[349, 608]] 1.0 3omv TKL_RAF1_HUMAN TKL 3.7e-81 278.6 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9O0UE P04049 339 613 648.0 324:701 Type1.5_Back Inactive DFGin 5.9555 13.4189 BLAplus -138.96, -169.14 62.02, 34.27 -105.27, 31.97 55.75, 93.21 -64.59, -47.5 out-none out 11.6319 Saltbr-none 999.0 HRD-in -66.55, -46.99 72.02, -8.83 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -79.43 APE8-dihe-in -132.83, 160.57 APE8-rot-out 180.68 APE67-dihe-in -62.16, -27.71 -107.14, -6.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.74 Y340D,Y341D None None XRAY 2.91 0.232 0.264 E 280.0 258.0 17 30 13 17 [[349, 608]] 1.0 9o0u TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9O0VE P04049 339 613 648.0 324:701 Type1.5_Back Inactive DFGin 5.8024 13.3404 BLAplus -138.88, -169.03 61.87, 34.79 -104.64, 32.35 56.09, 93.36 -64.43, -47.67 out-none out 11.5845 Saltbr-none 999.0 HRD-in -66.6, -47.0 72.05, -8.97 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 56.8, 24.32 APE9-dihe-na -101.33, -80.31 APE8-dihe-in -132.61, 160.7 APE8-rot-out 180.75 APE67-dihe-in -62.26, -27.57 -106.96, -6.66 APE12-dist-in 11.2624 APE11-dist-in 9.0411 APE10-dist-out 12.024 APE9-dist-out 9.4519 Y340D,Y341D None None XRAY 3.5 0.208 0.254 E 280.0 261.0 14 30 16 14 [[349, 608]] 1.0 9o0v TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9O0UC P04049 339 614 648.0 324:701 Type1 Inactive DFGin 6.4118 14.92 BLBminus -135.2, -162.93 65.39, 47.79 -89.17, 153.49 305.13, 119.24 148.83, -36.3 in-in in 8.1119 Saltbr-in 3.1081 HRD-in -65.51, -42.52 74.23, -8.63 in-in-out SNCiio in-out ActLoopNT-in 3.2736 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -140.95 APE9-dihe-na 87.04, -108.57 APE8-dihe-in -126.35, 163.82 APE8-rot-out 179.91 APE67-dihe-in -66.05, -28.24 -108.28, -15.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.537 APE9-dist-out 7.8436 Y340D,Y341D None None XRAY 2.91 0.232 0.264 C 280.0 264.0 12 30 18 12 [[349, 608]] 1.0 9o0u TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9O0VC P04049 339 614 648.0 324:701 Type1 Inactive DFGin 6.507 14.8484 BLBminus -135.62, -163.14 65.12, 48.02 -88.94, 153.23 304.77, 118.58 148.73, -35.99 in-in in 8.1644 Saltbr-in 3.3442 HRD-in -65.49, -42.82 73.84, -8.92 in-in-out SNCiio in-out ActLoopNT-in 3.3433 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -150.01 APE9-dihe-na 93.34, -107.4 APE8-dihe-in -126.38, 163.35 APE8-rot-out 180.01 APE67-dihe-in -65.89, -28.16 -108.44, -15.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.4019 APE9-dist-out 7.9115 Y340D,Y341D None None XRAY 3.5 0.208 0.254 C 280.0 264.0 12 30 18 12 [[349, 608]] 1.0 9o0v TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9AY7A P04049 343 612 648.0 ANP:701 ATPlike Inactive DFGin 5.8053 13.462 BLBplus -133.55, 174.37 58.47, 38.44 -90.49, 142.18 44.05, 90.72 78.29, -134.9 out-out out 14.0699 Saltbr-out 12.7376 HRD-in -73.02, -44.7 76.86, -25.12 out-out-out SNCooo out-out ActLoopNT-out 9.1822 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -145.48, 130.61 APE9-dihe-na 129.03, -169.57 APE8-dihe-in -79.63, 137.79 APE8-rot-in 302.79 APE67-dihe-in -63.4, -34.24 -69.33, -38.68 APE12-dist-out 15.2361 APE11-dist-out 15.0562 APE10-dist-out 10.6236 APE9-dist-out 6.3059 Y340D,Y341D None None XRAY 2.41 0.203 0.236 A 280.0 260.0 10 30 24 6 [[349, 608]] 1.0 9ay7 TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9MMRA P04049 343 625 648.0 AGS:60701 ATPlike Inactive DFGin 5.4464 13.6261 BLBplus -135.09, 172.16 58.87, 36.16 -92.53, 159.81 52.16, 102.21 63.65, -134.37 out-out out 13.8632 Saltbr-out 12.3622 HRD-out -74.45, 80.03 -68.85, 163.44 out-out-out SNCooo out-out ActLoopNT-out 8.7183 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -153.07, 160.07 APE9-dihe-na 91.95, -174.93 APE8-dihe-in -63.61, 140.51 APE8-rot-in 299.95 APE67-dihe-in -59.35, -38.77 -86.72, -25.37 APE12-dist-out 15.0543 APE11-dist-out 14.7515 APE10-dist-out 11.0339 APE9-dist-out 8.4046 Q156R,Y340D,Y341D,D587E SEP621 SEP621 EM 3.9 999.0 999.0 A 681.0 283.0 0 30 30 0 [[349, 608]] 1.0 9mmr TKL_RAF1_HUMAN TKL 2e-80 276.3 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9MMSA P04049 343 610 648.0 AGS:701 ATPlike Inactive DFGin 6.0432 13.4123 BLBplus -130.72, 176.22 57.09, 37.64 -95.88, 150.42 38.9, 90.55 70.15, -138.14 out-out out 13.239 Saltbr-out 11.9633 HRD-out -75.89, 77.72 -68.75, 167.65 out-out-out SNCooo out-out ActLoopNT-out 9.0132 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -153.3, 137.93 APE9-dihe-na 117.05, 178.36 APE8-dihe-in -66.7, 143.78 APE8-rot-in 289.18 APE67-dihe-in -66.49, -26.11 -89.17, -21.29 APE12-dist-out 15.1652 APE11-dist-out 14.8651 APE10-dist-out 10.7824 APE9-dist-out 8.09 Q156R,Y340D,Y341D,D587E None None EM 3.3 999.0 999.0 A 681.0 268.0 0 30 30 0 [[349, 608]] 1.0 9mms TKL_RAF1_HUMAN TKL 2e-80 276.3 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9MMQA P04049 341 612 648.0 AGS:701 ATPlike Inactive DFGin 6.0418 13.4878 BLBplus -128.47, 173.58 60.41, 41.33 -95.4, 154.76 40.5, 88.25 68.22, -137.22 out-out out 13.7306 Saltbr-out 12.7147 HRD-out -73.84, 78.36 -65.55, 163.21 out-out-out SNCooo out-out ActLoopNT-out 9.1331 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -154.13, 160.3 APE9-dihe-na 98.38, -176.64 APE8-dihe-in -67.06, 138.58 APE8-rot-in 288.86 APE67-dihe-in -64.64, -31.65 -87.38, -18.69 APE12-dist-out 15.1677 APE11-dist-out 14.4229 APE10-dist-out 10.8266 APE9-dist-out 8.1068 Q156R,D587E None None EM 2.9 999.0 999.0 A 681.0 272.0 0 30 30 0 [[349, 608]] 1.0 9mmq TKL_RAF1_HUMAN TKL 2e-80 276.3 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9MMPA P04049 138 630 648.0 AGS:60701 ATPlike Inactive DFGin 6.1073 13.2684 BLBplus -130.39, 177.17 56.68, 47.87 -99.84, 149.88 40.92, 87.91 73.17, -140.77 out-out out 14.3612 Saltbr-out 12.3822 HRD-out -74.8, 81.36 -67.74, 154.91 out-out-out SNCooo out-out ActLoopNT-out 9.1666 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -156.54, 146.13 APE9-dihe-na 117.78, -173.39 APE8-dihe-in -67.5, 146.42 APE8-rot-in 282.71 APE67-dihe-in -62.97, -41.04 -80.62, -35.94 APE12-dist-out 14.2949 APE11-dist-out 14.3656 APE10-dist-out 10.6756 APE9-dist-out 7.9092 Q156R,D587E SEP259,SEP621 SEP259,SEP621 EM 3.4 999.0 999.0 A 683.0 348.0 0 30 30 0 [[349, 608]] 1.0 9mmp TKL_RAF1_HUMAN TKL 2e-80 276.3 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9O0UA P04049 339 612 648.0 324:701 Type1.5_Back Inactive DFGin 5.49 13.4253 BLBplus -137.77, -168.21 60.54, 23.67 -97.39, 164.85 62.85, 94.03 74.33, 173.3 out-none out 11.6361 Saltbr-none 999.0 HRD-in -67.32, -47.26 72.53, -10.19 none-out-out SNCnoo out-out ActLoopNT-out 8.5215 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -79.91, 164.26 APE9-dihe-na 133.94, -179.25 APE8-dihe-in -151.13, 161.47 APE8-rot-out 181.14 APE67-dihe-in -63.28, -28.75 -107.76, -7.41 APE12-dist-out 21.2876 APE11-dist-out 15.3594 APE10-dist-out 15.2178 APE9-dist-out 10.0158 Y340D,Y341D None None XRAY 2.91 0.232 0.264 A 280.0 267.0 7 30 23 7 [[349, 608]] 1.0 9o0u TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 9O0VA P04049 339 612 648.0 324:701 Type1.5_Back Inactive DFGin 5.6121 13.5412 BLBplus -137.53, -168.14 60.68, 23.81 -97.37, 165.11 62.5, 93.91 74.63, 173.9 out-none out 11.5178 Saltbr-none 999.0 HRD-in -67.23, -47.12 72.36, -10.39 none-out-out SNCnoo out-out ActLoopNT-out 8.5821 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -121.31, 23.23 APE9-dihe-na -94.2, -61.86 APE8-dihe-in -150.39, 162.26 APE8-rot-out 181.1 APE67-dihe-in -63.35, -28.52 -106.79, -7.22 APE12-dist-out 14.0563 APE11-dist-in 11.3326 APE10-dist-out 13.0181 APE9-dist-out 9.5213 Y340D,Y341D None None XRAY 3.5 0.208 0.254 A 280.0 266.0 8 30 22 8 [[349, 608]] 1.0 9o0v TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 8CPDA P04049 341 626 648.0 No_ligand No_ligand Inactive DFGin 6.2527 14.8427 None -88.44, -129.65 -68.47, 153.64 -115.46, 32.54 280.62, 22.29 -59.2, -38.85 in-in in 8.9962 Saltbr-in 3.2393 HRD-out -71.21, -9.87 61.06, -133.06 in-in-out SNCiio in-out ActLoopNT-in 3.3344 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -31.3 APE9-dihe-na -64.2, -40.67 APE8-dihe-in -125.25, 125.51 APE8-rot-in 293.24 APE67-dihe-in -70.13, -31.13 -109.07, 11.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.0605 APE9-dist-out 15.3926 Y341D SEP621 SEP621 EM 3.46 999.0 999.0 A 648.0 269.0 17 30 18 12 [[349, 608]] 1.0 8cpd TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 8CPDB P04049 341 626 648.0 No_ligand No_ligand Inactive DFGin 6.3243 14.7834 None -88.37, -130.06 -68.25, 153.07 -115.22, 33.93 283.48, 10.19 -59.44, -38.94 in-in in 8.9968 Saltbr-in 3.2413 HRD-out -70.18, -11.24 60.41, -132.52 in-in-out SNCiio in-out ActLoopNT-in 3.2815 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -32.01 APE9-dihe-na -64.34, -40.91 APE8-dihe-in -123.99, 124.82 APE8-rot-in 292.66 APE67-dihe-in -70.59, -30.16 -110.37, 10.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.0602 APE9-dist-out 15.4329 Y341D SEP621 SEP621 EM 3.46 999.0 999.0 B 648.0 269.0 17 30 18 12 [[349, 608]] 1.0 8cpd TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 3OMVA P04049 340 615 648.0 SM5:1 Type1 Inactive DFGin 6.0105 14.0395 None -72.19, -157.95 -69.65, 158.45 -112.95, 18.14 298.92, 73.64 -38.54, -34.68 in-in in 8.8405 Saltbr-in 2.8181 HRD-in -81.59, -27.52 64.4, -79.14 in-in-out SNCiio in-out ActLoopNT-in 3.128 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -67.59, 120.25 APE9-dihe-na -106.5, 137.12 APE8-dihe-in -106.61, 64.59 APE8-rot-out 44.73 APE67-dihe-inflip 112.91, -48.44 -57.65, 161.85 APE12-dist-none 999.0 APE11-dist-in 13.3289 APE10-dist-out 12.1479 APE9-dist-out 10.4545 None None None XRAY 4.0 0.283 0.364 A 307.0 264.0 12 30 18 12 [[349, 608]] 1.0 3omv TKL_RAF1_HUMAN TKL 3.7e-81 278.6 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 8CHFA P04049 341 626 648.0 29L:60701 Type1 Inactive DFGin 6.9193 13.7979 None -77.69, -137.87 -62.1, 150.83 -123.34, 43.11 304.09, 90.48 -53.76, -47.63 in-out in 8.5922 Saltbr-out 6.6899 HRD-in -62.51, -43.32 69.96, -9.45 out-in-out SNCoio in-out ActLoopNT-in 2.8262 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na 55.74, 2.9 APE9-dihe-na 55.92, 40.68 APE8-dihe-in -131.33, 94.1 APE8-rot-out 59.25 APE67-dihe-inflip 81.42, -0.92 -97.97, 165.62 APE12-dist-in 7.3494 APE11-dist-in 11.6311 APE10-dist-in 6.9434 APE9-dist-out 10.1571 Y341D SEP621 SEP621 EM 4.25 0.445 999.0 A 648.0 280.0 6 30 24 6 [[349, 608]] 1.0 8chf TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 8CHFB P04049 341 626 648.0 29L:60701 Type1 Inactive DFGin 6.9191 13.7979 None -77.67, -137.85 -62.16, 150.83 -123.29, 43.03 304.08, 90.5 -53.73, -47.64 in-out in 8.5922 Saltbr-out 6.6905 HRD-in -62.53, -43.31 69.92, -9.4 out-in-out SNCoio in-out ActLoopNT-in 2.8268 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na 55.74, 2.9 APE9-dihe-na 55.89, 40.65 APE8-dihe-in -131.28, 94.15 APE8-rot-out 59.25 APE67-dihe-inflip 81.39, -0.89 -98.01, 165.61 APE12-dist-in 7.3494 APE11-dist-in 11.631 APE10-dist-in 6.9423 APE9-dist-out 10.1569 Y341D SEP621 SEP621 EM 4.25 0.445 999.0 B 648.0 280.0 6 30 24 6 [[349, 608]] 1.0 8chf TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 8GFTD P04049 404 611 648.0 No_ligand No_ligand Inactive None 999.0 999.0 None -164.39, -179.79 -89.82, 12.52 -72.24, -18.95 181.77, 70.31 -73.4, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.87, -46.27 64.82, -56.23 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, -56.49 APE9-dihe-na 100.69, -17.61 APE8-dihe-out -72.27, -36.0 APE8-rot-out 67.45 APE67-dihe-in -49.85, -47.25 -97.25, -47.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5368 None None None EM 3.8 999.0 999.0 D 304.0 191.0 72 30 13 17 [[349, 608]] 1.0 8gft TKL_RAF1_HUMAN TKL 3.6e-81 278.6 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 8U1LC P04049 418 615 648.0 No_ligand No_ligand Inactive None 999.0 999.0 None 87.15, 3.03 -74.84, 77.99 -74.97, 76.67 289.42, 93.79 116.56, -171.97 none-none none 999.0 Saltbr-none 999.0 HRD-out -100.67, 144.24 -121.66, -8.0 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na 51.33, 57.43 APE9-dihe-na 61.35, -123.96 APE8-dihe-out 55.11, 35.51 APE8-rot-in 302.03 APE67-dihe-in -59.19, -23.13 -70.4, -10.97 APE12-dist-none 999.0 APE11-dist-out 19.2568 APE10-dist-out 16.2609 APE9-dist-out 9.904 None None None EM 3.7 999.0 999.0 C 656.0 184.0 83 30 16 14 [[349, 608]] 1.0 8u1l TKL_RAF1_HUMAN TKL 3.1e-80 275.7 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 7Z37CP1 P04049 406 615 648.0 No_ligand No_ligand Inactive None 999.0 999.0 None -51.69, 113.04 -59.31, 132.91 -63.39, -37.52 182.06, 73.21 115.94, -41.02 none-none none 999.0 Saltbr-none 999.0 HRD-in -94.28, -51.52 64.79, -72.58 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -172.19 APE8-rot-out 162.56 APE67-dihe-inflip 70.01, -5.7 -83.36, 166.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.67 999.0 999.0 CP1 659.0 193.0 74 30 13 17 [[349, 608]] 1.0 7z37 TKL_RAF1_HUMAN TKL 1e-79 274.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 7Z38C P04049 406 615 648.0 No_ligand No_ligand Inactive None 999.0 999.0 None -54.5, 132.93 -69.32, 104.66 -85.43, 53.34 267.31, 92.72 60.74, -125.52 none-none none 999.0 Saltbr-none 999.0 HRD-in -113.4, -61.21 60.49, -2.03 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -92.5 APE8-rot-out 164.68 APE67-dihe-inflip 72.83, -7.22 -110.4, 137.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.16 999.0 999.0 C 659.0 193.0 74 30 13 17 [[349, 608]] 1.0 7z38 TKL_RAF1_HUMAN TKL 1e-79 274.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 8GAED P04049 404 610 648.0 No_ligand No_ligand Inactive None 999.0 999.0 None -126.25, -170.67 -128.75, -9.64 -62.05, -51.04 170.23, 78.51 57.98, 999.0 none-na none 999.0 Saltbr-na 999.0 HRD-out -112.46, 123.69 -73.96, 156.28 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -175.21 APE8-dihe-in -78.72, 159.13 APE8-rot-out 52.86 APE67-dihe-out -91.67, 147.13 -88.13, 88.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.09 None None None EM 3.3 999.0 999.0 D 207.0 189.0 18 30 12 18 [[349, 608]] 1.0 8gae TKL_RAF1_HUMAN TKL 4e-62 216.0 57.0 266.0 210.0 485 486 487 489 491 0 0 0 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase

TKL_RAF1 (RAF proto-oncogene serine/threonine-protein kinase)

Total number of chains: 32
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 11 34.4% AF-P04049-K1A
DFGin BLBplus 7 21.9% 9MMQA
DFGin None 5 15.6% 8CHFA
None None 5 15.6% 8GAED
DFGin BLAplus 2 6.2% 9O0VE
DFGin BLBminus 2 6.2% 9O0UC

Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
RAF1 RAF1_HUMAN AF-P04049-K1A P04049 341 616 648.0 No_ligand No_ligand Active DFGin 6.5203 13.7817 BLAminus -132.07, -167.34 50.52, 81.79 -93.0, 17.5 287.63, 84.75 -60.82, -26.68 in-in in 8.771 Saltbr-in 2.7908 HRD-in -75.2, -41.77 65.71, -17.78 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -82.32, 124.86 APE9-dihe-na 150.0, -177.65 APE8-dihe-in -88.86, 110.11 APE8-rot-in 297.22 APE67-dihe-in -59.64, -29.86 -48.29, -38.25 APE12-dist-in 13.3725 APE11-dist-in 11.5758 APE10-dist-in 7.2465 APE9-dist-in 5.6357 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 30 30 0 [[349, 608]] 1.0 AF-P04049-K1 Homo sapiens TKL_RAF1_HUMAN TKL 2.5e-81 279.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN AF-P04049-K3A P04049 341 616 648.0 No_ligand No_ligand Active DFGin 6.6956 13.8203 BLAminus -127.79, -164.94 51.29, 73.3 -87.25, 15.65 292.37, 90.99 -61.36, -23.57 in-in in 9.3042 Saltbr-in 2.9127 HRD-in -75.32, -37.72 66.17, -19.03 in-in-in SNCiii in-in ActLoopNT-in 2.9047 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.73, 136.21 APE9-dihe-na 118.54, -171.69 APE8-dihe-in -96.47, 111.5 APE8-rot-in 306.19 APE67-dihe-in -65.71, -24.96 -56.51, -31.57 APE12-dist-in 12.8315 APE11-dist-in 12.1084 APE10-dist-in 6.6368 APE9-dist-in 4.1332 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 30 30 0 [[349, 608]] 1.0 AF-P04049-K3 Homo sapiens TKL_RAF1_HUMAN TKL 2.5e-81 279.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9AYAA P04049 342 614 648.0 No_ligand No_ligand Inactive DFGin 6.3662 14.2668 BLAminus -136.12, -165.85 49.32, 86.99 -103.48, 21.74 291.83, 76.13 -59.74, -18.47 in-none in 9.0808 Saltbr-none 999.0 HRD-in -71.73, -48.54 69.99, 0.7 none-in-out SNCnio in-out ActLoopNT-in 2.8942 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -128.07, 13.13 APE9-dihe-na -91.19, -175.11 APE8-dihe-in -69.87, 137.88 APE8-rot-in 300.15 APE67-dihe-in -63.77, -25.92 -71.38, -32.74 APE12-dist-in 12.5452 APE11-dist-in 9.8883 APE10-dist-out 8.8439 APE9-dist-in 5.9778 Y340D,Y341D None None XRAY 2.59 0.214 0.257 A 280.0 267.0 6 30 30 0 [[349, 608]] 1.0 9aya Homo sapiens TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9AYAC P04049 341 613 648.0 No_ligand No_ligand Inactive DFGin 6.5551 14.821 BLAminus -133.94, -166.68 54.0, 73.37 -92.76, 23.95 288.97, 82.99 -61.86, -28.32 in-in in 8.7648 Saltbr-in 2.8037 HRD-in -69.13, -44.61 68.35, -7.89 in-in-out SNCiio in-out ActLoopNT-in 2.8119 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 53.27, 27.21 APE9-dihe-na -96.24, -140.6 APE8-dihe-in -94.61, 133.74 APE8-rot-out 177.74 APE67-dihe-in -62.64, -31.47 -74.96, -14.97 APE12-dist-in 12.0325 APE11-dist-in 8.2808 APE10-dist-out 10.5493 APE9-dist-out 7.7979 Y340D,Y341D None None XRAY 2.59 0.214 0.257 C 280.0 263.0 10 30 30 0 [[349, 608]] 1.0 9aya Homo sapiens TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9AXAA P04049 342 625 648.0 No_ligand No_ligand Inactive DFGin 7.2548 13.9989 BLAminus -139.05, -163.7 58.24, 64.96 -89.4, 29.46 290.36, 82.23 -69.56, -16.76 in-out in 9.18 Saltbr-out 8.4188 HRD-in -78.78, -32.03 70.97, -14.05 out-in-out SNCoio in-out ActLoopNT-in 3.116 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -130.3, -20.74 APE9-dihe-na -70.73, -178.58 APE8-dihe-in -67.69, 139.48 APE8-rot-in 293.88 APE67-dihe-in -69.75, -43.45 -74.78, -4.77 APE12-dist-in 12.0486 APE11-dist-in 9.617 APE10-dist-out 9.0441 APE9-dist-out 7.5911 Y340D,Y341D SEP621 SEP621 EM 4.36 999.0 999.0 A 563.0 273.0 11 30 25 5 [[349, 608]] 1.0 9axa Homo sapiens TKL_RAF1_HUMAN TKL 2.2e-80 276.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9AXAC P04049 341 625 648.0 No_ligand No_ligand Inactive DFGin 7.3924 14.9903 BLAminus -146.66, -157.9 56.49, 63.39 -91.79, 31.37 293.16, 80.76 -67.87, -25.57 in-out in 8.9755 Saltbr-out 10.0011 HRD-in -78.03, -41.77 71.76, -11.87 out-in-out SNCoio in-out ActLoopNT-in 2.7588 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 54.52, 48.67 APE9-dihe-na -119.18, -141.08 APE8-dihe-in -96.15, 129.35 APE8-rot-out 174.93 APE67-dihe-in -72.88, -14.72 -74.49, -3.91 APE12-dist-in 11.8542 APE11-dist-in 9.1816 APE10-dist-out 11.2816 APE9-dist-out 9.0508 Y340D,Y341D SEP621 SEP621 EM 4.36 999.0 999.0 C 563.0 275.0 10 30 30 0 [[349, 608]] 1.0 9axa Homo sapiens TKL_RAF1_HUMAN TKL 2.2e-80 276.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9AXCA P04049 342 614 648.0 No_ligand No_ligand Inactive DFGin 7.1921 14.4156 BLAminus -138.33, -166.81 57.53, 66.49 -89.8, 33.05 291.57, 76.32 -64.02, -29.91 in-out in 9.5136 Saltbr-out 7.6297 HRD-in -72.6, -42.02 72.95, -10.85 out-in-out SNCoio in-out ActLoopNT-in 3.1646 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -134.52, -16.63 APE9-dihe-na -73.85, -175.48 APE8-dihe-in -71.62, 149.24 APE8-rot-in 297.36 APE67-dihe-in -71.32, -46.0 -82.78, -6.02 APE12-dist-in 12.2652 APE11-dist-in 10.7655 APE10-dist-out 9.0117 APE9-dist-out 7.1409 Y340D,Y341D None None EM 4.16 999.0 999.0 A 563.0 262.0 11 30 25 5 [[349, 608]] 1.0 9axc Homo sapiens TKL_RAF1_HUMAN TKL 2.2e-80 276.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9AXCC P04049 341 614 648.0 No_ligand No_ligand Inactive DFGin 7.0993 14.2941 BLAminus -140.87, -159.63 58.35, 65.16 -89.93, 32.3 288.78, 78.02 -61.68, -35.06 in-out in 8.1468 Saltbr-out 3.9477 HRD-in -77.54, -28.87 66.49, -1.91 out-in-out SNCoio in-out ActLoopNT-in 2.6755 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 42.59, 31.87 APE9-dihe-na -96.68, -133.02 APE8-dihe-in -109.92, 127.09 APE8-rot-out 177.26 APE67-dihe-in -75.55, -23.65 -73.76, -3.99 APE12-dist-in 11.8637 APE11-dist-in 8.5952 APE10-dist-out 11.1083 APE9-dist-out 8.7613 Y340D,Y341D None None EM 4.16 999.0 999.0 C 563.0 264.0 10 30 30 0 [[349, 608]] 1.0 9axc Homo sapiens TKL_RAF1_HUMAN TKL 2.2e-80 276.1 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9O0UG P04049 341 614 648.0 324:701 Type1 Inactive DFGin 6.6427 14.5362 BLAminus -137.03, -164.72 64.05, 59.07 -91.31, 23.03 298.27, 111.42 -70.02, -22.85 in-in in 8.466 Saltbr-in 2.7929 HRD-in -67.69, -46.18 73.87, -6.26 in-in-out SNCiio in-out ActLoopNT-in 3.4083 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -147.61, -172.9 APE9-dihe-na 96.11, -111.47 APE8-dihe-in -121.52, 159.07 APE8-rot-out 179.33 APE67-dihe-in -61.77, -27.13 -108.62, -7.48 APE12-dist-in 9.3284 APE11-dist-in 9.0351 APE10-dist-out 10.4777 APE9-dist-out 9.744 Y340D,Y341D None None XRAY 2.91 0.232 0.264 G 280.0 265.0 9 30 21 9 [[349, 608]] 1.0 9o0u Homo sapiens TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9O0VG P04049 341 614 648.0 324:701 Type1 Inactive DFGin 6.6518 14.5256 BLAminus -136.91, -164.75 63.88, 58.79 -91.51, 23.22 298.64, 111.76 -69.75, -22.63 in-in in 8.5288 Saltbr-in 2.8267 HRD-in -68.13, -46.19 73.7, -5.88 in-in-out SNCiio in-out ActLoopNT-in 3.3624 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -144.93, -171.41 APE9-dihe-na 95.72, -110.34 APE8-dihe-in -121.89, 159.4 APE8-rot-out 179.42 APE67-dihe-in -62.17, -27.08 -108.22, -7.65 APE12-dist-in 9.3788 APE11-dist-in 8.988 APE10-dist-out 10.4038 APE9-dist-out 9.6609 Y340D,Y341D None None XRAY 3.5 0.208 0.254 G 280.0 265.0 9 30 21 9 [[349, 608]] 1.0 9o0v Homo sapiens TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 3OMVB P04049 340 615 648.0 SM5:2 Type1 Inactive DFGin 6.2314 14.1198 BLAminus -128.39, -171.12 47.91, 84.95 -94.99, 35.62 285.33, 59.46 -60.18, -20.41 in-in in 8.4734 Saltbr-in 2.9066 HRD-in -95.5, -25.99 55.76, -81.98 in-in-out SNCiio in-out ActLoopNT-in 3.4203 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nooo APE10-dihe-na -64.38, 160.65 APE9-dihe-na -138.85, -166.53 APE8-dihe-in -147.75, 73.1 APE8-rot-out 58.68 APE67-dihe-out 164.31, -56.84 -70.36, 119.54 APE12-dist-none 999.0 APE11-dist-out 14.3402 APE10-dist-out 13.4894 APE9-dist-out 10.3958 None None None XRAY 4.0 0.283 0.364 B 307.0 264.0 12 30 18 12 [[349, 608]] 1.0 3omv Homo sapiens TKL_RAF1_HUMAN TKL 3.7e-81 278.6 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9O0UE P04049 339 613 648.0 324:701 Type1.5_Back Inactive DFGin 5.9555 13.4189 BLAplus -138.96, -169.14 62.02, 34.27 -105.27, 31.97 55.75, 93.21 -64.59, -47.5 out-none out 11.6319 Saltbr-none 999.0 HRD-in -66.55, -46.99 72.02, -8.83 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -79.43 APE8-dihe-in -132.83, 160.57 APE8-rot-out 180.68 APE67-dihe-in -62.16, -27.71 -107.14, -6.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.74 Y340D,Y341D None None XRAY 2.91 0.232 0.264 E 280.0 258.0 17 30 13 17 [[349, 608]] 1.0 9o0u Homo sapiens TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9O0VE P04049 339 613 648.0 324:701 Type1.5_Back Inactive DFGin 5.8024 13.3404 BLAplus -138.88, -169.03 61.87, 34.79 -104.64, 32.35 56.09, 93.36 -64.43, -47.67 out-none out 11.5845 Saltbr-none 999.0 HRD-in -66.6, -47.0 72.05, -8.97 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 56.8, 24.32 APE9-dihe-na -101.33, -80.31 APE8-dihe-in -132.61, 160.7 APE8-rot-out 180.75 APE67-dihe-in -62.26, -27.57 -106.96, -6.66 APE12-dist-in 11.2624 APE11-dist-in 9.0411 APE10-dist-out 12.024 APE9-dist-out 9.4519 Y340D,Y341D None None XRAY 3.5 0.208 0.254 E 280.0 261.0 14 30 16 14 [[349, 608]] 1.0 9o0v Homo sapiens TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9O0UC P04049 339 614 648.0 324:701 Type1 Inactive DFGin 6.4118 14.92 BLBminus -135.2, -162.93 65.39, 47.79 -89.17, 153.49 305.13, 119.24 148.83, -36.3 in-in in 8.1119 Saltbr-in 3.1081 HRD-in -65.51, -42.52 74.23, -8.63 in-in-out SNCiio in-out ActLoopNT-in 3.2736 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -140.95 APE9-dihe-na 87.04, -108.57 APE8-dihe-in -126.35, 163.82 APE8-rot-out 179.91 APE67-dihe-in -66.05, -28.24 -108.28, -15.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.537 APE9-dist-out 7.8436 Y340D,Y341D None None XRAY 2.91 0.232 0.264 C 280.0 264.0 12 30 18 12 [[349, 608]] 1.0 9o0u Homo sapiens TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9O0VC P04049 339 614 648.0 324:701 Type1 Inactive DFGin 6.507 14.8484 BLBminus -135.62, -163.14 65.12, 48.02 -88.94, 153.23 304.77, 118.58 148.73, -35.99 in-in in 8.1644 Saltbr-in 3.3442 HRD-in -65.49, -42.82 73.84, -8.92 in-in-out SNCiio in-out ActLoopNT-in 3.3433 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -150.01 APE9-dihe-na 93.34, -107.4 APE8-dihe-in -126.38, 163.35 APE8-rot-out 180.01 APE67-dihe-in -65.89, -28.16 -108.44, -15.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.4019 APE9-dist-out 7.9115 Y340D,Y341D None None XRAY 3.5 0.208 0.254 C 280.0 264.0 12 30 18 12 [[349, 608]] 1.0 9o0v Homo sapiens TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9AY7A P04049 343 612 648.0 ANP:701 ATPlike Inactive DFGin 5.8053 13.462 BLBplus -133.55, 174.37 58.47, 38.44 -90.49, 142.18 44.05, 90.72 78.29, -134.9 out-out out 14.0699 Saltbr-out 12.7376 HRD-in -73.02, -44.7 76.86, -25.12 out-out-out SNCooo out-out ActLoopNT-out 9.1822 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -145.48, 130.61 APE9-dihe-na 129.03, -169.57 APE8-dihe-in -79.63, 137.79 APE8-rot-in 302.79 APE67-dihe-in -63.4, -34.24 -69.33, -38.68 APE12-dist-out 15.2361 APE11-dist-out 15.0562 APE10-dist-out 10.6236 APE9-dist-out 6.3059 Y340D,Y341D None None XRAY 2.41 0.203 0.236 A 280.0 260.0 10 30 24 6 [[349, 608]] 1.0 9ay7 Homo sapiens TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9MMRA P04049 343 625 648.0 AGS:60701 ATPlike Inactive DFGin 5.4464 13.6261 BLBplus -135.09, 172.16 58.87, 36.16 -92.53, 159.81 52.16, 102.21 63.65, -134.37 out-out out 13.8632 Saltbr-out 12.3622 HRD-out -74.45, 80.03 -68.85, 163.44 out-out-out SNCooo out-out ActLoopNT-out 8.7183 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -153.07, 160.07 APE9-dihe-na 91.95, -174.93 APE8-dihe-in -63.61, 140.51 APE8-rot-in 299.95 APE67-dihe-in -59.35, -38.77 -86.72, -25.37 APE12-dist-out 15.0543 APE11-dist-out 14.7515 APE10-dist-out 11.0339 APE9-dist-out 8.4046 Q156R,Y340D,Y341D,D587E SEP621 SEP621 EM 3.9 999.0 999.0 A 681.0 283.0 0 30 30 0 [[349, 608]] 1.0 9mmr Homo sapiens TKL_RAF1_HUMAN TKL 2e-80 276.3 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9MMSA P04049 343 610 648.0 AGS:701 ATPlike Inactive DFGin 6.0432 13.4123 BLBplus -130.72, 176.22 57.09, 37.64 -95.88, 150.42 38.9, 90.55 70.15, -138.14 out-out out 13.239 Saltbr-out 11.9633 HRD-out -75.89, 77.72 -68.75, 167.65 out-out-out SNCooo out-out ActLoopNT-out 9.0132 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -153.3, 137.93 APE9-dihe-na 117.05, 178.36 APE8-dihe-in -66.7, 143.78 APE8-rot-in 289.18 APE67-dihe-in -66.49, -26.11 -89.17, -21.29 APE12-dist-out 15.1652 APE11-dist-out 14.8651 APE10-dist-out 10.7824 APE9-dist-out 8.09 Q156R,Y340D,Y341D,D587E None None EM 3.3 999.0 999.0 A 681.0 268.0 0 30 30 0 [[349, 608]] 1.0 9mms Homo sapiens TKL_RAF1_HUMAN TKL 2e-80 276.3 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9MMQA P04049 341 612 648.0 AGS:701 ATPlike Inactive DFGin 6.0418 13.4878 BLBplus -128.47, 173.58 60.41, 41.33 -95.4, 154.76 40.5, 88.25 68.22, -137.22 out-out out 13.7306 Saltbr-out 12.7147 HRD-out -73.84, 78.36 -65.55, 163.21 out-out-out SNCooo out-out ActLoopNT-out 9.1331 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -154.13, 160.3 APE9-dihe-na 98.38, -176.64 APE8-dihe-in -67.06, 138.58 APE8-rot-in 288.86 APE67-dihe-in -64.64, -31.65 -87.38, -18.69 APE12-dist-out 15.1677 APE11-dist-out 14.4229 APE10-dist-out 10.8266 APE9-dist-out 8.1068 Q156R,D587E None None EM 2.9 999.0 999.0 A 681.0 272.0 0 30 30 0 [[349, 608]] 1.0 9mmq Homo sapiens TKL_RAF1_HUMAN TKL 2e-80 276.3 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9MMPA P04049 138 630 648.0 AGS:60701 ATPlike Inactive DFGin 6.1073 13.2684 BLBplus -130.39, 177.17 56.68, 47.87 -99.84, 149.88 40.92, 87.91 73.17, -140.77 out-out out 14.3612 Saltbr-out 12.3822 HRD-out -74.8, 81.36 -67.74, 154.91 out-out-out SNCooo out-out ActLoopNT-out 9.1666 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -156.54, 146.13 APE9-dihe-na 117.78, -173.39 APE8-dihe-in -67.5, 146.42 APE8-rot-in 282.71 APE67-dihe-in -62.97, -41.04 -80.62, -35.94 APE12-dist-out 14.2949 APE11-dist-out 14.3656 APE10-dist-out 10.6756 APE9-dist-out 7.9092 Q156R,D587E SEP259,SEP621 SEP259,SEP621 EM 3.4 999.0 999.0 A 683.0 348.0 0 30 30 0 [[349, 608]] 1.0 9mmp Homo sapiens TKL_RAF1_HUMAN TKL 2e-80 276.3 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9O0UA P04049 339 612 648.0 324:701 Type1.5_Back Inactive DFGin 5.49 13.4253 BLBplus -137.77, -168.21 60.54, 23.67 -97.39, 164.85 62.85, 94.03 74.33, 173.3 out-none out 11.6361 Saltbr-none 999.0 HRD-in -67.32, -47.26 72.53, -10.19 none-out-out SNCnoo out-out ActLoopNT-out 8.5215 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -79.91, 164.26 APE9-dihe-na 133.94, -179.25 APE8-dihe-in -151.13, 161.47 APE8-rot-out 181.14 APE67-dihe-in -63.28, -28.75 -107.76, -7.41 APE12-dist-out 21.2876 APE11-dist-out 15.3594 APE10-dist-out 15.2178 APE9-dist-out 10.0158 Y340D,Y341D None None XRAY 2.91 0.232 0.264 A 280.0 267.0 7 30 23 7 [[349, 608]] 1.0 9o0u Homo sapiens TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 9O0VA P04049 339 612 648.0 324:701 Type1.5_Back Inactive DFGin 5.6121 13.5412 BLBplus -137.53, -168.14 60.68, 23.81 -97.37, 165.11 62.5, 93.91 74.63, 173.9 out-none out 11.5178 Saltbr-none 999.0 HRD-in -67.23, -47.12 72.36, -10.39 none-out-out SNCnoo out-out ActLoopNT-out 8.5821 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -121.31, 23.23 APE9-dihe-na -94.2, -61.86 APE8-dihe-in -150.39, 162.26 APE8-rot-out 181.1 APE67-dihe-in -63.35, -28.52 -106.79, -7.22 APE12-dist-out 14.0563 APE11-dist-in 11.3326 APE10-dist-out 13.0181 APE9-dist-out 9.5213 Y340D,Y341D None None XRAY 3.5 0.208 0.254 A 280.0 266.0 8 30 22 8 [[349, 608]] 1.0 9o0v Homo sapiens TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 8CPDA P04049 341 626 648.0 No_ligand No_ligand Inactive DFGin 6.2527 14.8427 None -88.44, -129.65 -68.47, 153.64 -115.46, 32.54 280.62, 22.29 -59.2, -38.85 in-in in 8.9962 Saltbr-in 3.2393 HRD-out -71.21, -9.87 61.06, -133.06 in-in-out SNCiio in-out ActLoopNT-in 3.3344 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -31.3 APE9-dihe-na -64.2, -40.67 APE8-dihe-in -125.25, 125.51 APE8-rot-in 293.24 APE67-dihe-in -70.13, -31.13 -109.07, 11.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.0605 APE9-dist-out 15.3926 Y341D SEP621 SEP621 EM 3.46 999.0 999.0 A 648.0 269.0 17 30 18 12 [[349, 608]] 1.0 8cpd Homo sapiens TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 8CPDB P04049 341 626 648.0 No_ligand No_ligand Inactive DFGin 6.3243 14.7834 None -88.37, -130.06 -68.25, 153.07 -115.22, 33.93 283.48, 10.19 -59.44, -38.94 in-in in 8.9968 Saltbr-in 3.2413 HRD-out -70.18, -11.24 60.41, -132.52 in-in-out SNCiio in-out ActLoopNT-in 3.2815 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -32.01 APE9-dihe-na -64.34, -40.91 APE8-dihe-in -123.99, 124.82 APE8-rot-in 292.66 APE67-dihe-in -70.59, -30.16 -110.37, 10.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.0602 APE9-dist-out 15.4329 Y341D SEP621 SEP621 EM 3.46 999.0 999.0 B 648.0 269.0 17 30 18 12 [[349, 608]] 1.0 8cpd Homo sapiens TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 3OMVA P04049 340 615 648.0 SM5:1 Type1 Inactive DFGin 6.0105 14.0395 None -72.19, -157.95 -69.65, 158.45 -112.95, 18.14 298.92, 73.64 -38.54, -34.68 in-in in 8.8405 Saltbr-in 2.8181 HRD-in -81.59, -27.52 64.4, -79.14 in-in-out SNCiio in-out ActLoopNT-in 3.128 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -67.59, 120.25 APE9-dihe-na -106.5, 137.12 APE8-dihe-in -106.61, 64.59 APE8-rot-out 44.73 APE67-dihe-inflip 112.91, -48.44 -57.65, 161.85 APE12-dist-none 999.0 APE11-dist-in 13.3289 APE10-dist-out 12.1479 APE9-dist-out 10.4545 None None None XRAY 4.0 0.283 0.364 A 307.0 264.0 12 30 18 12 [[349, 608]] 1.0 3omv Homo sapiens TKL_RAF1_HUMAN TKL 3.7e-81 278.6 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 8CHFA P04049 341 626 648.0 29L:60701 Type1 Inactive DFGin 6.9193 13.7979 None -77.69, -137.87 -62.1, 150.83 -123.34, 43.11 304.09, 90.48 -53.76, -47.63 in-out in 8.5922 Saltbr-out 6.6899 HRD-in -62.51, -43.32 69.96, -9.45 out-in-out SNCoio in-out ActLoopNT-in 2.8262 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na 55.74, 2.9 APE9-dihe-na 55.92, 40.68 APE8-dihe-in -131.33, 94.1 APE8-rot-out 59.25 APE67-dihe-inflip 81.42, -0.92 -97.97, 165.62 APE12-dist-in 7.3494 APE11-dist-in 11.6311 APE10-dist-in 6.9434 APE9-dist-out 10.1571 Y341D SEP621 SEP621 EM 4.25 0.445 999.0 A 648.0 280.0 6 30 24 6 [[349, 608]] 1.0 8chf Homo sapiens TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 8CHFB P04049 341 626 648.0 29L:60701 Type1 Inactive DFGin 6.9191 13.7979 None -77.67, -137.85 -62.16, 150.83 -123.29, 43.03 304.08, 90.5 -53.73, -47.64 in-out in 8.5922 Saltbr-out 6.6905 HRD-in -62.53, -43.31 69.92, -9.4 out-in-out SNCoio in-out ActLoopNT-in 2.8268 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na 55.74, 2.9 APE9-dihe-na 55.89, 40.65 APE8-dihe-in -131.28, 94.15 APE8-rot-out 59.25 APE67-dihe-inflip 81.39, -0.89 -98.01, 165.61 APE12-dist-in 7.3494 APE11-dist-in 11.631 APE10-dist-in 6.9423 APE9-dist-out 10.1569 Y341D SEP621 SEP621 EM 4.25 0.445 999.0 B 648.0 280.0 6 30 24 6 [[349, 608]] 1.0 8chf Homo sapiens TKL_RAF1_HUMAN TKL 3e-80 275.8 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 8GFTD P04049 404 611 648.0 No_ligand No_ligand Inactive None 999.0 999.0 None -164.39, -179.79 -89.82, 12.52 -72.24, -18.95 181.77, 70.31 -73.4, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.87, -46.27 64.82, -56.23 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, -56.49 APE9-dihe-na 100.69, -17.61 APE8-dihe-out -72.27, -36.0 APE8-rot-out 67.45 APE67-dihe-in -49.85, -47.25 -97.25, -47.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5368 None None None EM 3.8 999.0 999.0 D 304.0 191.0 72 30 13 17 [[349, 608]] 1.0 8gft Homo sapiens TKL_RAF1_HUMAN TKL 3.6e-81 278.6 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 8U1LC P04049 418 615 648.0 No_ligand No_ligand Inactive None 999.0 999.0 None 87.15, 3.03 -74.84, 77.99 -74.97, 76.67 289.42, 93.79 116.56, -171.97 none-none none 999.0 Saltbr-none 999.0 HRD-out -100.67, 144.24 -121.66, -8.0 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na 51.33, 57.43 APE9-dihe-na 61.35, -123.96 APE8-dihe-out 55.11, 35.51 APE8-rot-in 302.03 APE67-dihe-in -59.19, -23.13 -70.4, -10.97 APE12-dist-none 999.0 APE11-dist-out 19.2568 APE10-dist-out 16.2609 APE9-dist-out 9.904 None None None EM 3.7 999.0 999.0 C 656.0 184.0 83 30 16 14 [[349, 608]] 1.0 8u1l Homo sapiens TKL_RAF1_HUMAN TKL 3.1e-80 275.7 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 7Z37CP1 P04049 406 615 648.0 No_ligand No_ligand Inactive None 999.0 999.0 None -51.69, 113.04 -59.31, 132.91 -63.39, -37.52 182.06, 73.21 115.94, -41.02 none-none none 999.0 Saltbr-none 999.0 HRD-in -94.28, -51.52 64.79, -72.58 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -172.19 APE8-rot-out 162.56 APE67-dihe-inflip 70.01, -5.7 -83.36, 166.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.67 999.0 999.0 CP1 659.0 193.0 74 30 13 17 [[349, 608]] 1.0 7z37 Homo sapiens TKL_RAF1_HUMAN TKL 1e-79 274.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 7Z38C P04049 406 615 648.0 No_ligand No_ligand Inactive None 999.0 999.0 None -54.5, 132.93 -69.32, 104.66 -85.43, 53.34 267.31, 92.72 60.74, -125.52 none-none none 999.0 Saltbr-none 999.0 HRD-in -113.4, -61.21 60.49, -2.03 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -92.5 APE8-rot-out 164.68 APE67-dihe-inflip 72.83, -7.22 -110.4, 137.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.16 999.0 999.0 C 659.0 193.0 74 30 13 17 [[349, 608]] 1.0 7z38 Homo sapiens TKL_RAF1_HUMAN TKL 1e-79 274.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
RAF1 RAF1_HUMAN 8GAED P04049 404 610 648.0 No_ligand No_ligand Inactive None 999.0 999.0 None -126.25, -170.67 -128.75, -9.64 -62.05, -51.04 170.23, 78.51 57.98, 999.0 none-na none 999.0 Saltbr-na 999.0 HRD-out -112.46, 123.69 -73.96, 156.28 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -175.21 APE8-dihe-in -78.72, 159.13 APE8-rot-out 52.86 APE67-dihe-out -91.67, 147.13 -88.13, 88.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.09 None None None EM 3.3 999.0 999.0 D 207.0 189.0 18 30 12 18 [[349, 608]] 1.0 8gae Homo sapiens TKL_RAF1_HUMAN TKL 4e-62 216.0 57.0 266.0 210.0 485 486 487 489 491 0 0 0 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase

TKL_RAF1 (RAF proto-oncogene serine/threonine-protein kinase)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name